CN1917866B - 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 - Google Patents

曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 Download PDF

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CN1917866B
CN1917866B CN2004800417809A CN200480041780A CN1917866B CN 1917866 B CN1917866 B CN 1917866B CN 2004800417809 A CN2004800417809 A CN 2004800417809A CN 200480041780 A CN200480041780 A CN 200480041780A CN 1917866 B CN1917866 B CN 1917866B
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treprostinil
disease
pharmaceutically acceptable
ischemic
acceptable salt
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CN1917866A (zh
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M·沃德
R·A·杰夫斯
R·洛斯奇诺
D·斯特鲁特曼
K·布龙施泰因
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United Therapeutics Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Heart & Thoracic Surgery (AREA)
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  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CN2004800417809A 2003-12-16 2004-12-16 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 Expired - Fee Related CN1917866B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52962203P 2003-12-16 2003-12-16
US60/529,622 2003-12-16
PCT/US2004/042283 WO2005058303A1 (en) 2003-12-16 2004-12-16 Use of treprostinil to treat and prevent ischemic lesions

Related Child Applications (1)

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CN2009101645686A Division CN101647792B (zh) 2003-12-16 2004-12-16 曲前列环素在制备治疗和预防缺血性损害的药物中的用途

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CN1917866A CN1917866A (zh) 2007-02-21
CN1917866B true CN1917866B (zh) 2010-12-15

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CN2004800417809A Expired - Fee Related CN1917866B (zh) 2003-12-16 2004-12-16 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
CN2009101645686A Expired - Fee Related CN101647792B (zh) 2003-12-16 2004-12-16 曲前列环素在制备治疗和预防缺血性损害的药物中的用途

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US (1) US8765813B2 (https=)
EP (1) EP1696900B1 (https=)
JP (2) JP5190200B2 (https=)
KR (1) KR101161889B1 (https=)
CN (2) CN1917866B (https=)
AT (1) ATE473736T1 (https=)
CA (1) CA2549724C (https=)
DE (1) DE602004028155D1 (https=)
ES (1) ES2347254T3 (https=)
WO (1) WO2005058303A1 (https=)

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CN1917866A (zh) 2007-02-21
JP2007514750A (ja) 2007-06-07
ATE473736T1 (de) 2010-07-15
KR101161889B1 (ko) 2012-07-02
US8765813B2 (en) 2014-07-01
EP1696900A1 (en) 2006-09-06
US20050165111A1 (en) 2005-07-28
CN101647792B (zh) 2012-11-28
CA2549724A1 (en) 2005-06-30
DE602004028155D1 (de) 2010-08-26
JP2013047235A (ja) 2013-03-07
EP1696900B1 (en) 2010-07-14
JP5190200B2 (ja) 2013-04-24
CN101647792A (zh) 2010-02-17
ES2347254T3 (es) 2010-10-27
CA2549724C (en) 2014-02-11
WO2005058303A1 (en) 2005-06-30
KR20060123483A (ko) 2006-12-01

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