CN1898255B - 制备吡啶衍生物的方法 - Google Patents
制备吡啶衍生物的方法 Download PDFInfo
- Publication number
- CN1898255B CN1898255B CN2004800388844A CN200480038884A CN1898255B CN 1898255 B CN1898255 B CN 1898255B CN 2004800388844 A CN2004800388844 A CN 2004800388844A CN 200480038884 A CN200480038884 A CN 200480038884A CN 1898255 B CN1898255 B CN 1898255B
- Authority
- CN
- China
- Prior art keywords
- propyl
- pyridine
- general formula
- ethyl
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 150000003222 pyridines Chemical class 0.000 title abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 20
- 150000001728 carbonyl compounds Chemical class 0.000 claims abstract description 17
- 238000006130 Horner-Wadsworth-Emmons olefination reaction Methods 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims description 26
- -1 phosphorus compound Chemical class 0.000 claims description 22
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 238000003786 synthesis reaction Methods 0.000 claims description 9
- 229910021536 Zeolite Inorganic materials 0.000 claims description 8
- 229910052799 carbon Chemical group 0.000 claims description 8
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 8
- 239000010457 zeolite Substances 0.000 claims description 8
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 5
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
- 229910052698 phosphorus Inorganic materials 0.000 claims description 5
- 239000011574 phosphorus Substances 0.000 claims description 5
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 238000007171 acid catalysis Methods 0.000 claims 1
- 238000005815 base catalysis Methods 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 239000000460 chlorine Substances 0.000 description 16
- 229910052731 fluorine Inorganic materials 0.000 description 16
- 229910052801 chlorine Inorganic materials 0.000 description 15
- 229910052794 bromium Inorganic materials 0.000 description 13
- 229910052740 iodine Inorganic materials 0.000 description 13
- 125000004093 cyano group Chemical group *C#N 0.000 description 12
- XPYGGHVSFMUHLH-UUSULHAXSA-N falecalcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(O)(C(F)(F)F)C(F)(F)F)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C XPYGGHVSFMUHLH-UUSULHAXSA-N 0.000 description 12
- 239000000543 intermediate Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 9
- 229910052717 sulfur Inorganic materials 0.000 description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000002585 base Substances 0.000 description 8
- 229910052736 halogen Inorganic materials 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- 239000011593 sulfur Substances 0.000 description 8
- 125000004104 aryloxy group Chemical group 0.000 description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 150000002367 halogens Chemical class 0.000 description 7
- 239000012074 organic phase Substances 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- YKYIFUROKBDHCY-ONEGZZNKSA-N (e)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one Chemical compound CCO\C=C\C(=O)C(F)(F)F YKYIFUROKBDHCY-ONEGZZNKSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 6
- 125000006575 electron-withdrawing group Chemical group 0.000 description 6
- 239000012044 organic layer Substances 0.000 description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 description 6
- 235000011152 sodium sulphate Nutrition 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- IKHLLNMSMFVTLP-UHFFFAOYSA-N 4-(trifluoromethyl)-1h-pyridin-2-one Chemical compound OC1=CC(C(F)(F)F)=CC=N1 IKHLLNMSMFVTLP-UHFFFAOYSA-N 0.000 description 5
- 125000004122 cyclic group Chemical group 0.000 description 5
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- DOHMYCHHQMEIKO-UHFFFAOYSA-N ethyl 4,4-diethoxy-2-(trifluoromethyl)pent-2-enoate Chemical compound C(C)OC(C(=CC(C)(OCC)OCC)C(F)(F)F)=O DOHMYCHHQMEIKO-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- CERDCNUMTCLHAP-UHFFFAOYSA-N 2-ethoxy-4-(trifluoromethyl)pyridine Chemical compound CCOC1=CC(C(F)(F)F)=CC=N1 CERDCNUMTCLHAP-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- 150000001342 alkaline earth metals Chemical class 0.000 description 3
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 3
- 239000012159 carrier gas Substances 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 229910052744 lithium Inorganic materials 0.000 description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 150000002900 organolithium compounds Chemical class 0.000 description 3
- 150000003018 phosphorus compounds Chemical class 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 3
- 125000003944 tolyl group Chemical group 0.000 description 3
- FKTXDTWDCPTPHK-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical group FC(F)(F)[C](F)C(F)(F)F FKTXDTWDCPTPHK-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000007848 Bronsted acid Substances 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- RENMDAKOXSCIGH-UHFFFAOYSA-N Chloroacetonitrile Chemical compound ClCC#N RENMDAKOXSCIGH-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- WQOXQRCZOLPYPM-UHFFFAOYSA-N dimethyl disulfide Chemical compound CSSC WQOXQRCZOLPYPM-UHFFFAOYSA-N 0.000 description 2
- 125000006343 heptafluoro propyl group Chemical group 0.000 description 2
- 239000004009 herbicide Substances 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 150000004678 hydrides Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- JILPJDVXYVTZDQ-UHFFFAOYSA-N lithium methoxide Chemical compound [Li+].[O-]C JILPJDVXYVTZDQ-UHFFFAOYSA-N 0.000 description 2
- AZVCGYPLLBEUNV-UHFFFAOYSA-N lithium;ethanolate Chemical compound [Li+].CC[O-] AZVCGYPLLBEUNV-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 2
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 description 1
- IAPHALVOYNQNCU-UHFFFAOYSA-N 1-amino-5,5,5-trifluoropent-1-en-3-one Chemical compound NC=CC(=O)CC(F)(F)F IAPHALVOYNQNCU-UHFFFAOYSA-N 0.000 description 1
- UZHGLXNTFUDBAQ-UHFFFAOYSA-N 4,4-diethoxy-2-(trifluoromethyl)pent-2-enoic acid Chemical compound FC(F)(F)C(C(=O)O)=CC(C)(OCC)OCC UZHGLXNTFUDBAQ-UHFFFAOYSA-N 0.000 description 1
- AHZDTXAEITWOEF-UHFFFAOYSA-N 5,5-diethoxy-2-methylsulfanyl-3-(trifluoromethyl)pent-2-enenitrile Chemical compound CCOC(OCC)CC(=C(SC)C#N)C(F)(F)F AHZDTXAEITWOEF-UHFFFAOYSA-N 0.000 description 1
- JNYLMODTPLSLIF-UHFFFAOYSA-N 6-(trifluoromethyl)pyridine-3-carboxylic acid Chemical group OC(=O)C1=CC=C(C(F)(F)F)N=C1 JNYLMODTPLSLIF-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- AUSMCLJZDNXPSB-UHFFFAOYSA-N CCC(CC)(C#N)P(=O)=O Chemical compound CCC(CC)(C#N)P(=O)=O AUSMCLJZDNXPSB-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- AGATVUQBOGDEJQ-UHFFFAOYSA-N P(=O)(=O)CC(=O)OCC Chemical compound P(=O)(=O)CC(=O)OCC AGATVUQBOGDEJQ-UHFFFAOYSA-N 0.000 description 1
- 238000003482 Pinner synthesis reaction Methods 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- CQAYJDMWUGRKOJ-UHFFFAOYSA-N acetyloxy-oxido-oxophosphanium Chemical compound CC(=O)O[P+]([O-])=O CQAYJDMWUGRKOJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960003750 ethyl chloride Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910000103 lithium hydride Inorganic materials 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 238000006198 methoxylation reaction Methods 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53161403P | 2003-12-23 | 2003-12-23 | |
| EP03029730 | 2003-12-23 | ||
| EP03029730.3 | 2003-12-23 | ||
| US60/531,614 | 2003-12-23 | ||
| PCT/EP2004/014590 WO2005063780A1 (en) | 2003-12-23 | 2004-12-22 | Process for the preparation of pyridine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1898255A CN1898255A (zh) | 2007-01-17 |
| CN1898255B true CN1898255B (zh) | 2010-06-09 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800388844A Expired - Lifetime CN1898255B (zh) | 2003-12-23 | 2004-12-22 | 制备吡啶衍生物的方法 |
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| EP (1) | EP1723156B1 (enExample) |
| JP (3) | JP5160092B2 (enExample) |
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| CN (1) | CN1898255B (enExample) |
| AR (1) | AR046775A1 (enExample) |
| AU (1) | AU2004309054B2 (enExample) |
| BR (1) | BRPI0418047B8 (enExample) |
| CA (1) | CA2550693C (enExample) |
| DK (1) | DK1723156T3 (enExample) |
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| IL (1) | IL176472A (enExample) |
| IN (2) | IN2012DN02546A (enExample) |
| PL (1) | PL1723156T3 (enExample) |
| WO (1) | WO2005063780A1 (enExample) |
| ZA (1) | ZA200605471B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7678920B2 (en) * | 2004-04-08 | 2010-03-16 | Dow Agrosciences Llc | Insecticidal N-substituted sulfoximines |
| US7488828B2 (en) * | 2004-06-25 | 2009-02-10 | Dow Agrosciences Llc | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone |
| TW201309635A (zh) | 2006-02-10 | 2013-03-01 | Dow Agrosciences Llc | 殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺（二） |
| TWI381811B (zh) * | 2006-06-23 | 2013-01-11 | Dow Agrosciences Llc | 用以防治可抵抗一般殺蟲劑之昆蟲的方法 |
| TWI387585B (zh) * | 2006-09-01 | 2013-03-01 | Dow Agrosciences Llc | 殺蟲性之ｎ-取代（雜芳基）烷基烴基硫亞胺 |
| WO2008027539A1 (en) * | 2006-09-01 | 2008-03-06 | Dow Agrosciences Llc | Insecticidal n-substituted (2- sudstituted-1,3-thiazol) alkyl sulfoximines |
| TWI395736B (zh) * | 2006-11-08 | 2013-05-11 | Dow Agrosciences Llc | 作為殺蟲劑之雜芳基（取代的）烷基ｎ-取代的磺醯亞胺（二） |
| US7709648B2 (en) * | 2007-02-09 | 2010-05-04 | Dow Agrosciences Llc | Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines |
| AR066366A1 (es) * | 2007-05-01 | 2009-08-12 | Dow Agrosciences Llc | Mezclas sinergicas plaguicidas |
| US20090023782A1 (en) * | 2007-07-20 | 2009-01-22 | Dow Agrosciences Llc | Increasing plant vigor |
| CN102015634B (zh) * | 2008-03-03 | 2014-02-12 | 陶氏益农公司 | 杀虫剂 |
| CN102875548A (zh) * | 2011-07-14 | 2013-01-16 | 中国科学院大连化学物理研究所 | 一类基于肟的通过[2+2+2]环加成合成吡啶衍生物的方法 |
| EP2607343A1 (en) | 2011-12-22 | 2013-06-26 | Solvay Sa | Process for the manufacture of halogenated precursors of alkenones and of alkenones |
| US10961248B2 (en) * | 2016-12-01 | 2021-03-30 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
| US12077505B2 (en) | 2018-12-27 | 2024-09-03 | Corteva Agriscience Llc | Preparation of sulfonamide herbicide process intermediates |
| CN120172888A (zh) * | 2018-12-27 | 2025-06-20 | 科迪华农业科技有限责任公司 | 磺酰胺除草剂方法中间体的制备 |
| CN115286568B (zh) * | 2022-08-24 | 2023-12-12 | 常州沃腾化工科技有限公司 | 一种2-羟基-4-三氟甲基吡啶的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993656A (en) * | 1974-11-19 | 1976-11-23 | Merck & Co., Inc. | 1,8-Naphthyridine compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE611728A (fr) * | 1960-07-12 | 1962-06-19 | American Cyanamid Co | Perfectionnements aux compositions contenant des antibiotiques à base de tétracycline |
| JPS5221196A (en) * | 1975-08-12 | 1977-02-17 | Fujio Hashimoto | Device for removing red tide |
| JPS5384990A (en) * | 1976-12-29 | 1978-07-26 | Yamanouchi Pharmaceut Co Ltd | Novel nitrogen-containing heterocyclic compound and its preparation |
| JPS53121764A (en) * | 1977-03-31 | 1978-10-24 | Yamanouchi Pharmaceut Co Ltd | Heterocyclic compounds and process for their preparation |
| JPS53127490A (en) * | 1977-04-13 | 1978-11-07 | Yamanouchi Pharmaceut Co Ltd | Novel nitrogen-containing heterocyclic compound |
| JPS55104266A (en) * | 1979-02-02 | 1980-08-09 | Yamanouchi Pharmaceut Co Ltd | Novel pyridone derivative |
| JPS6210087A (ja) * | 1985-07-03 | 1987-01-19 | Shionogi & Co Ltd | ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤 |
| JPS6413065A (en) * | 1987-07-06 | 1989-01-17 | Mitsubishi Chem Ind | Peptide derivative of beta-chloro-l-(z)- dehydroglutamic acid |
| DK177191D0 (da) * | 1991-10-23 | 1991-10-23 | Novo Nordisk As | Heterocyclic compounds and their preparation and use |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| PL190282B1 (pl) | 1996-09-24 | 2005-11-30 | Dow Agrosciences Llc | Związki N-([1,2,4]triazoloazynylo)benzeno-i pirydynosulfonamidowe, zawierające je kompozycje herbicydowe, pochodne chlorku pirydyno-3-sulfonylu i pochodne 2-amino[1.2.4]triazolo[1.5-c]pirymidyny |
| JP4533534B2 (ja) * | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| JP2004504300A (ja) * | 2000-07-18 | 2004-02-12 | ビーエーエスエフ アクチェンゲゼルシャフト | １−アリール−４−ハロアルキル−２−［１ｈ］ピリドン類 |
| US6399781B1 (en) | 2000-10-10 | 2002-06-04 | Boehringer Ingelheim Chemicals, Inc. | Process for making 3-amino-2-chloro-4-methylpyridine |
| US7488828B2 (en) * | 2004-06-25 | 2009-02-10 | Dow Agrosciences Llc | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone |
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- 2004-12-11 ZA ZA200605471A patent/ZA200605471B/en unknown
- 2004-12-22 JP JP2006546051A patent/JP5160092B2/ja not_active Expired - Lifetime
- 2004-12-22 EP EP04804186.7A patent/EP1723156B1/en not_active Expired - Lifetime
- 2004-12-22 KR KR1020067012653A patent/KR101164694B1/ko not_active Expired - Lifetime
- 2004-12-22 PL PL04804186T patent/PL1723156T3/pl unknown
- 2004-12-22 WO PCT/EP2004/014590 patent/WO2005063780A1/en not_active Ceased
- 2004-12-22 AU AU2004309054A patent/AU2004309054B2/en not_active Expired
- 2004-12-22 IN IN2546DEN2012 patent/IN2012DN02546A/en unknown
- 2004-12-22 CN CN2004800388844A patent/CN1898255B/zh not_active Expired - Lifetime
- 2004-12-22 ES ES04804186.7T patent/ES2528716T3/es not_active Expired - Lifetime
- 2004-12-22 IN IN2545DEN2012 patent/IN2012DN02545A/en unknown
- 2004-12-22 DK DK04804186.7T patent/DK1723156T3/en active
- 2004-12-22 AR ARP040104854A patent/AR046775A1/es active IP Right Grant
- 2004-12-22 CA CA2550693A patent/CA2550693C/en not_active Expired - Lifetime
- 2004-12-22 US US10/584,354 patent/US7687632B2/en active Active
- 2004-12-22 BR BRPI0418047A patent/BRPI0418047B8/pt not_active IP Right Cessation
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- 2006-06-21 IL IL176472A patent/IL176472A/en active IP Right Grant
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2012
- 2012-06-21 JP JP2012139429A patent/JP2012214487A/ja active Pending
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3993656A (en) * | 1974-11-19 | 1976-11-23 | Merck & Co., Inc. | 1,8-Naphthyridine compounds |
Non-Patent Citations (4)
| Title |
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| KNOEVENAGEL, W. CREMER.SYNTHESEN IN DER PYRIDINREIHE. UEBERDIEEINWIRKUNG VON MALONESTER UNDMALONAMIDAUF AMINOACETYLACETON.CHEM.BERICHTE.1902,2390-2396. * |
| KNOEVENAGEL,W.CREMER.SYNTHESEN IN DER PYRIDINREIHE. UEBERDIEEINWIRKUNG VON MALONESTER UNDMALONAMIDAUF AMINOACETYLACETON.CHEM.BERICHTE.1902,2390-2396. * |
| REUBEN G.J. ET AL..PREPARATION AND REACTIONS OFSOMEPENTA-SUBSTITUTED PYRIDINES.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY73 12.1951,73(12),5610-5614. * |
| REUBEN G.J.ET AL..PREPARATION AND REACTIONS OFSOMEPENTA-SUBSTITUTED PYRIDINES.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY73 12.1951,73(12),5610-5614. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200605471B (en) | 2007-11-28 |
| AU2004309054A1 (en) | 2005-07-14 |
| BRPI0418047A (pt) | 2007-04-17 |
| KR20060128896A (ko) | 2006-12-14 |
| DK1723156T3 (en) | 2015-04-27 |
| AR046775A1 (es) | 2005-12-21 |
| PL1723156T3 (pl) | 2015-07-31 |
| CA2550693C (en) | 2013-07-30 |
| BRPI0418047B8 (pt) | 2022-06-28 |
| IL176472A (en) | 2010-11-30 |
| AU2004309054B2 (en) | 2010-07-08 |
| JP5160092B2 (ja) | 2013-03-13 |
| JP2007519625A (ja) | 2007-07-19 |
| CN1898255A (zh) | 2007-01-17 |
| IN2012DN02546A (enExample) | 2015-08-28 |
| EP1723156B1 (en) | 2015-01-21 |
| BRPI0418047B1 (pt) | 2013-12-31 |
| ES2528716T3 (es) | 2015-02-12 |
| IL176472A0 (en) | 2006-10-05 |
| US7687632B2 (en) | 2010-03-30 |
| KR101164694B1 (ko) | 2012-07-11 |
| CA2550693A1 (en) | 2005-07-14 |
| WO2005063780A1 (en) | 2005-07-14 |
| JP2012214487A (ja) | 2012-11-08 |
| JP2013047245A (ja) | 2013-03-07 |
| EP1723156A1 (en) | 2006-11-22 |
| IN2012DN02545A (enExample) | 2015-07-17 |
| US20070249837A1 (en) | 2007-10-25 |
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