CN1839150A - 脂肽抗菌衍生物组合物及其应用方法 - Google Patents

脂肽抗菌衍生物组合物及其应用方法 Download PDF

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Publication number
CN1839150A
CN1839150A CNA200480020655XA CN200480020655A CN1839150A CN 1839150 A CN1839150 A CN 1839150A CN A200480020655X A CNA200480020655X A CN A200480020655XA CN 200480020655 A CN200480020655 A CN 200480020655A CN 1839150 A CN1839150 A CN 1839150A
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CN
China
Prior art keywords
compound
acid
amino acid
alkyl
aryl
Prior art date
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Pending
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CNA200480020655XA
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English (en)
Chinese (zh)
Inventor
戴尔·R·卡梅伦
文森特·A·博伊德
理查德·A·利斯
威廉·V·柯伦
唐纳德·B·博德斯
保罗·W·M·斯加尔比
雪莉·A·瓦克维希·斯加尔比
马修·诺德维尔
陈玉琛
贾琦
多米尼克·迪古尔
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Biowest Therapeutics Inc
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Migenix Inc
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Publication date
Application filed by Migenix Inc filed Critical Migenix Inc
Publication of CN1839150A publication Critical patent/CN1839150A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA200480020655XA 2003-07-17 2004-06-28 脂肽抗菌衍生物组合物及其应用方法 Pending CN1839150A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48833103P 2003-07-17 2003-07-17
US60/488,331 2003-07-17
US56491204P 2004-04-23 2004-04-23
US60/564,912 2004-04-23

Publications (1)

Publication Number Publication Date
CN1839150A true CN1839150A (zh) 2006-09-27

Family

ID=36203969

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200480020655XA Pending CN1839150A (zh) 2003-07-17 2004-06-28 脂肽抗菌衍生物组合物及其应用方法

Country Status (11)

Country Link
US (1) US7868135B2 (https=)
EP (2) EP1656390A2 (https=)
JP (1) JP2007536200A (https=)
CN (1) CN1839150A (https=)
AU (1) AU2004252174A1 (https=)
CA (1) CA2530063A1 (https=)
EA (1) EA010294B1 (https=)
IL (1) IL172647A0 (https=)
NZ (1) NZ544750A (https=)
WO (1) WO2005000878A2 (https=)
ZA (1) ZA200600008B (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939301A (zh) * 2010-03-10 2013-02-20 巴塞罗那大学 作为抗菌剂使用的肽化合物
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
CN104817619A (zh) * 2015-04-23 2015-08-05 浙江大学 抗菌化合物及其应用
CN107108698A (zh) * 2014-11-14 2017-08-29 百时美施贵宝公司 用作免疫调节剂的大环肽
CN109593808A (zh) * 2017-09-30 2019-04-09 上海医药工业研究院 达托霉素发酵培养基及其制备方法
CN111434775A (zh) * 2019-01-11 2020-07-21 上海医药工业研究院 一种发酵制备达托霉素的方法
CN112625106A (zh) * 2021-01-13 2021-04-09 兰州大学 一种抗菌多肽化合物、合成方法及其应用
US12209106B2 (en) 2018-07-20 2025-01-28 Fujimoto Chemicals Co., Ltd. Alkoxyphenyl derivatives, protected nucleosides and protected nucleotides, method for producing oligonucleotides, and method for removing substituents

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WO2007092632A2 (en) * 2006-02-09 2007-08-16 Elevance Renawable Sciences, Inc. Surface coating compositions and methods
RU2008132757A (ru) * 2006-02-09 2010-03-20 Елевансе Реневал Сайенсез, Инк. (US) Антибактериальные составы, способы и системы
GB0821540D0 (en) * 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
JP5719783B2 (ja) 2009-02-16 2015-05-20 セレニス セラピューティクス ホールディング エスアー アポリポタンパクａ−ｉ模倣物
DE102009060102A1 (de) * 2009-12-21 2011-06-22 Martin-Luther-Universität Halle-Wittenberg, 06108 Derivatisierungsreagenzien zur tandem-massenspektrometrischen Quantifizierung von Proteinen
CN102939095A (zh) * 2010-03-09 2013-02-20 默沙东公司 增强β-内酰胺抗菌药物的活性的桥联脂糖肽类
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP2703410B1 (en) * 2012-08-28 2015-10-14 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie Jagaricin, derivatives, and uses thereof
KR20150088292A (ko) 2012-11-21 2015-07-31 알큐엑스 파마슈티컬스, 인크. 광범위한 마크로사이클릭 항생제
WO2015179441A2 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
CN105231000B (zh) * 2015-09-25 2020-01-07 广东海洋大学 一种利用水产品下脚料生产抗菌营养复合型饲料添加剂的方法
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
CA3058953A1 (en) * 2017-04-05 2018-10-11 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
EP3833329A1 (en) * 2018-08-06 2021-06-16 Khan, Khalid Antimicrobial formulations comprising vancomycin or tobramycin
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения

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DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
WO2002005837A1 (en) * 2000-07-17 2002-01-24 Intrabiotics Pharmaceuticals, Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
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US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
JP4402463B2 (ja) 2002-01-03 2010-01-20 マイジェニックス インコーポレイテッド リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939301A (zh) * 2010-03-10 2013-02-20 巴塞罗那大学 作为抗菌剂使用的肽化合物
CN107108698A (zh) * 2014-11-14 2017-08-29 百时美施贵宝公司 用作免疫调节剂的大环肽
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
CN104817619A (zh) * 2015-04-23 2015-08-05 浙江大学 抗菌化合物及其应用
CN104817619B (zh) * 2015-04-23 2018-07-17 浙江大学 抗菌化合物及其应用
CN109593808A (zh) * 2017-09-30 2019-04-09 上海医药工业研究院 达托霉素发酵培养基及其制备方法
CN109593808B (zh) * 2017-09-30 2022-10-04 上海医药工业研究院 达托霉素发酵培养基及其制备方法
US12209106B2 (en) 2018-07-20 2025-01-28 Fujimoto Chemicals Co., Ltd. Alkoxyphenyl derivatives, protected nucleosides and protected nucleotides, method for producing oligonucleotides, and method for removing substituents
CN111434775A (zh) * 2019-01-11 2020-07-21 上海医药工业研究院 一种发酵制备达托霉素的方法
CN111434775B (zh) * 2019-01-11 2022-12-06 上海医药工业研究院 一种发酵制备达托霉素的方法
CN112625106A (zh) * 2021-01-13 2021-04-09 兰州大学 一种抗菌多肽化合物、合成方法及其应用

Also Published As

Publication number Publication date
JP2007536200A (ja) 2007-12-13
EP2147925A1 (en) 2010-01-27
AU2004252174A1 (en) 2005-01-06
ZA200600008B (en) 2007-09-26
EP1656390A2 (en) 2006-05-17
WO2005000878A2 (en) 2005-01-06
US7868135B2 (en) 2011-01-11
NZ544750A (en) 2009-06-26
EA010294B1 (ru) 2008-08-29
EA200600280A1 (ru) 2006-10-27
CA2530063A1 (en) 2005-01-06
US20050153876A1 (en) 2005-07-14
WO2005000878A3 (en) 2005-06-16
WO2005000878A8 (en) 2006-06-08
IL172647A0 (en) 2006-04-10

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