CA2530063A1 - Compositions of lipopeptide antibiotic derivatives and methods of use thereof - Google Patents

Compositions of lipopeptide antibiotic derivatives and methods of use thereof Download PDF

Info

Publication number
CA2530063A1
CA2530063A1 CA002530063A CA2530063A CA2530063A1 CA 2530063 A1 CA2530063 A1 CA 2530063A1 CA 002530063 A CA002530063 A CA 002530063A CA 2530063 A CA2530063 A CA 2530063A CA 2530063 A1 CA2530063 A1 CA 2530063A1
Authority
CA
Canada
Prior art keywords
compound
acid
amphomycin
substituted
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002530063A
Other languages
English (en)
French (fr)
Inventor
Dale R. Cameron
Vincent A. Boyd
Richard A. Leese
William V. Curran
Donald B. Borders
Paulo W.M. Sgarbi
Shirley A. Wacowich-Sgarbi
Matthew Nodwell
Yuchen Chen
Qi Jia
Dominique Dugourd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biowest Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2530063A1 publication Critical patent/CA2530063A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002530063A 2003-06-26 2004-06-28 Compositions of lipopeptide antibiotic derivatives and methods of use thereof Abandoned CA2530063A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48298503P 2003-06-26 2003-06-26
US48833103P 2003-07-17 2003-07-17
US60/488,331 2003-07-17
US56491204P 2004-04-23 2004-04-23
US60/564,912 2004-04-23
PCT/US2004/021039 WO2005000878A2 (en) 2003-06-26 2004-06-28 Compositions of lipopeptide antibiotic derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2530063A1 true CA2530063A1 (en) 2005-01-06

Family

ID=36203969

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002530063A Abandoned CA2530063A1 (en) 2003-06-26 2004-06-28 Compositions of lipopeptide antibiotic derivatives and methods of use thereof

Country Status (11)

Country Link
US (1) US7868135B2 (https=)
EP (2) EP2147925A1 (https=)
JP (1) JP2007536200A (https=)
CN (1) CN1839150A (https=)
AU (1) AU2004252174A1 (https=)
CA (1) CA2530063A1 (https=)
EA (1) EA010294B1 (https=)
IL (1) IL172647A0 (https=)
NZ (1) NZ544750A (https=)
WO (1) WO2005000878A2 (https=)
ZA (1) ZA200600008B (https=)

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US20080033026A1 (en) * 2006-02-09 2008-02-07 Zullo Jill L Antimicrobial compositions, methods and systems
GB0821540D0 (en) * 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
LT2939683T (lt) 2009-02-16 2017-03-27 Cerenis Therapeutics Holding Sa Apolipoproteino a-i mimetikai
DE102009060102A1 (de) * 2009-12-21 2011-06-22 Martin-Luther-Universität Halle-Wittenberg, 06108 Derivatisierungsreagenzien zur tandem-massenspektrometrischen Quantifizierung von Proteinen
MX2012010381A (es) * 2010-03-09 2012-11-23 Merck Canada Inc Lipoglicopeptidos en puente que potencian la actividad de antibacterianos de beta-lactama.
ES2374779B1 (es) * 2010-03-10 2012-12-27 Universidad De Barcelona Compuestos péptidicos útiles como agentes antibacterianos.
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP2703410B1 (en) * 2012-08-28 2015-10-14 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie Jagaricin, derivatives, and uses thereof
EA201590871A1 (ru) 2012-11-21 2015-11-30 АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК. Макроциклические антибиотики широкого спектра действия
BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
US9856292B2 (en) * 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
CN104557743A (zh) * 2014-12-02 2015-04-29 南京邮电大学 一类包含不饱和脂肪酸结构的抗白色念珠菌药物及其制备方法
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
CN104817619B (zh) * 2015-04-23 2018-07-17 浙江大学 抗菌化合物及其应用
CN105231000B (zh) * 2015-09-25 2020-01-07 广东海洋大学 一种利用水产品下脚料生产抗菌营养复合型饲料添加剂的方法
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
AU2018248417A1 (en) * 2017-04-05 2019-11-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
CN109593808B (zh) * 2017-09-30 2022-10-04 上海医药工业研究院 达托霉素发酵培养基及其制备方法
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
JP6770553B2 (ja) 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
WO2020031083A1 (en) * 2018-08-06 2020-02-13 KHAN, Khalid Antimicrobial formulations comprising vancomycin or tobramycin
CN111434775B (zh) * 2019-01-11 2022-12-06 上海医药工业研究院 一种发酵制备达托霉素的方法
ES2961566T3 (es) 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения
CN112625106B (zh) * 2021-01-13 2023-03-31 兰州大学 一种抗菌多肽化合物、合成方法及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923544A (en) 1959-07-21 1963-04-10 Takeda Pharmaceutical A new antibiotic-glumamycin
US3057779A (en) 1960-03-14 1962-10-09 American Cyanamid Co Antibiotic and production thereof
US3639582A (en) 1967-04-14 1972-02-01 Zaidan Hojin Biseibutsu Antibiotic laspartomycin
DE1800363A1 (de) 1967-10-04 1969-07-03 Shionogi & Co Tsushimycin und seine Herstellung
FR2124060B1 (https=) 1971-02-02 1974-04-12 Rhone Poulenc Sa
IL61604A (en) 1977-07-22 1981-10-30 Baxter Travenol Lab Flexible collapsible containers
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
CA1315229C (en) 1987-06-10 1993-03-30 Eli Lilly And Company Chromatographic purification process
US4994270A (en) 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5039789A (en) 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4977083A (en) 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
US5028590A (en) 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
TW455591B (en) 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0933422A4 (en) 1996-06-13 2005-02-02 Fujisawa Pharmaceutical Co CYCLIC LIPOPEPTIDE ACYLASE
DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
US6716962B2 (en) 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
AU7893301A (en) * 2000-07-17 2002-01-30 Intrabiotics Pharmaceuticals Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US7125844B2 (en) 2002-01-03 2006-10-24 Migenix Inc. Dab9 derivatives of lipopeptide antibiotics and methods of making and using the same

Also Published As

Publication number Publication date
EA010294B1 (ru) 2008-08-29
WO2005000878A3 (en) 2005-06-16
EP1656390A2 (en) 2006-05-17
IL172647A0 (en) 2006-04-10
EP2147925A1 (en) 2010-01-27
WO2005000878A2 (en) 2005-01-06
NZ544750A (en) 2009-06-26
WO2005000878A8 (en) 2006-06-08
US20050153876A1 (en) 2005-07-14
US7868135B2 (en) 2011-01-11
CN1839150A (zh) 2006-09-27
ZA200600008B (en) 2007-09-26
JP2007536200A (ja) 2007-12-13
AU2004252174A1 (en) 2005-01-06
EA200600280A1 (ru) 2006-10-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued