CN101970459B - 抗微生物化合物 - Google Patents
抗微生物化合物 Download PDFInfo
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- CN101970459B CN101970459B CN200880126952.0A CN200880126952A CN101970459B CN 101970459 B CN101970459 B CN 101970459B CN 200880126952 A CN200880126952 A CN 200880126952A CN 101970459 B CN101970459 B CN 101970459B
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- 238000001291 vacuum drying Methods 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
EMRSA16金黄色葡萄球菌(MRSA)-SSCmec型2 | 4 | 4 |
EMRSA1金黄色葡萄球菌(MRSA)-SSCmec型3 | 8 | 8 |
EMRSA15金黄色葡萄球菌(MRSA)-SSCmec型4 | 4 | 4 |
HT2001254金黄色葡萄球菌(MRSA)-PVL阳性 | 4 | 4 |
无乳链球菌-抗生-敏感性临床分离菌株 | 16 | 8 |
无乳链球菌-大环内酯耐药性临床分离菌株 | 32 | 16 |
C群链球菌-抗生-敏感性临床分离菌株 | 32 | 16 |
C群链球菌-大环内酯耐药性临床分离菌株 | 64 | 32 |
G群链球菌-抗生-敏感性临床分离菌株 | 32 | 8, |
G群链球菌-大环内酯耐药性临床分离菌株 | 32 | 16 |
缓症链球菌-抗生-敏感性临床分离菌株 | 64 | 16 |
缓症链球菌-大环内酯耐药性临床分离菌株 | ≥128 | 32 |
星座链球菌-抗生-敏感性临床分离菌株 | 64 | 32 |
星座链球菌-大环内酯耐药性临床分离菌株 | 64 | 32 |
口腔链球菌-抗生-敏感性临床分离菌株 | 64 | 32 |
口腔链球菌-大环内酯耐药性临床分离菌株 | 32 | 32 |
牛链球菌-抗生-敏感性临床分离菌株 | 64 | 32 |
牛链球菌-大环内酯耐药性临床分离菌株 | 8 | 8 |
血链球菌-抗生-敏感性临床分离菌株 | 64 | 32 |
血链球菌-大环内酯耐药性临床分离菌株 | 32 | 32 |
产气荚膜梭菌-抗生-敏感性临床分离菌株 | ≥128 | 32 |
艰梭状芽孢杆菌(Clostridium difficile)-抗生-敏感性临床分离菌株 | 32 | 16 |
材料 | 供应商 |
两性霉素B | Sigma,UK |
ATP标准品 | Sigma,UK |
BacTiter-GloTM | PROMEGA,UK |
乙醇 | Fisher,UK |
沙氏葡糖琼脂 | Oxoid,UK |
林格氏液 | Oxoid,UK |
盐酸特比萘芬 | Hetero Labs Limited,India |
Tween 80 | Merck,Germany |
Y-Z | 大肠杆菌 | 金黄色葡萄球菌 | MRSA | 化脓性链球菌 |
-(CH2)2-(2-BrPh) | 6 | 3 | 3 | 3 |
Claims (6)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0724951.9 | 2007-12-20 | ||
GBGB0724951.9A GB0724951D0 (en) | 2007-12-20 | 2007-12-20 | Compounds |
PCT/GB2008/004245 WO2009081152A2 (en) | 2007-12-20 | 2008-12-22 | Antimicrobial compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101970459A CN101970459A (zh) | 2011-02-09 |
CN101970459B true CN101970459B (zh) | 2015-11-25 |
Family
ID=39048523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880126952.0A Active CN101970459B (zh) | 2007-12-20 | 2008-12-22 | 抗微生物化合物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8598114B2 (zh) |
EP (1) | EP2235041B1 (zh) |
JP (1) | JP5524858B2 (zh) |
CN (1) | CN101970459B (zh) |
AU (1) | AU2008339611B2 (zh) |
CA (1) | CA2709884C (zh) |
CY (1) | CY1115239T1 (zh) |
DK (1) | DK2235041T3 (zh) |
ES (1) | ES2468250T3 (zh) |
GB (1) | GB0724951D0 (zh) |
HR (1) | HRP20140466T1 (zh) |
PL (1) | PL2235041T3 (zh) |
PT (1) | PT2235041E (zh) |
RS (1) | RS53326B (zh) |
SI (1) | SI2235041T1 (zh) |
WO (1) | WO2009081152A2 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0818074D0 (en) | 2008-10-02 | 2008-11-05 | Lytix Biopharma As | Treatment of biofilms |
GB0818072D0 (en) * | 2008-10-02 | 2008-11-05 | Lytix Biopharma As | Compounds |
GB0919194D0 (en) * | 2009-11-02 | 2009-12-16 | Lytix Biopharma As | Compounds |
EP2570453A1 (en) | 2011-09-14 | 2013-03-20 | Center of Excellence Polymer Materials and Technologies (Polimat) | Antimicrobial polymeric substrates |
WO2014191789A1 (en) * | 2013-05-27 | 2014-12-04 | Universite Pierre Et Marie Curie (Paris 6) | New cationic amino acids, pharmaceutical compositions containing the same and their use for the treatment of bacterial infections |
GB202008980D0 (en) * | 2020-06-12 | 2020-07-29 | Amicoat As | Medical devices and materials |
GB202008978D0 (en) * | 2020-06-12 | 2020-07-29 | Amicoat As | Antimicrobial formulation |
GB202103872D0 (en) | 2021-03-19 | 2021-05-05 | Pharma Holdings As | Uses and methods |
CA3207775A1 (en) | 2021-03-26 | 2022-09-29 | Christian Lutken | Compounds for use in the treatment of sinusitis, pneumonia or otitis |
GB202108465D0 (en) * | 2021-06-14 | 2021-07-28 | Amicoat As | Antimicrobial articles |
GB202109626D0 (en) | 2021-07-02 | 2021-08-18 | Amicoat As | Method |
US20240390451A1 (en) | 2021-10-25 | 2024-11-28 | Pharma Holdings As | Modified tripeptides for use in the treatment of a non-enveloped virus infection |
WO2024146948A1 (en) | 2023-01-05 | 2024-07-11 | Amicoat As | Peptide synthesis method involving sterically hindered tri-tert-butyl-tryptophan (tbt) residue |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006086321A2 (en) * | 2005-02-09 | 2006-08-17 | Helix Biomedix Inc. | Antimicrobial hexapeptides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2337923A1 (en) * | 2000-02-25 | 2001-08-25 | Raymond J. Andersen | Peptide antibiotics |
GB0005703D0 (en) | 2000-03-09 | 2000-05-03 | Alpharma As | Compounds |
WO2003097664A2 (en) | 2002-05-15 | 2003-11-27 | National Research Council Of Canada | Non-covalent inhibitors of cysteine proteases with atripeptide backbone |
EP1633380A4 (en) | 2003-06-19 | 2010-08-11 | Yeda Res & Dev | ANTIMICROBIAL AND ANTICANCER LIPOPEPTIDES |
-
2007
- 2007-12-20 GB GBGB0724951.9A patent/GB0724951D0/en not_active Ceased
-
2008
- 2008-12-22 US US12/808,941 patent/US8598114B2/en active Active
- 2008-12-22 AU AU2008339611A patent/AU2008339611B2/en active Active
- 2008-12-22 DK DK08865440.5T patent/DK2235041T3/da active
- 2008-12-22 WO PCT/GB2008/004245 patent/WO2009081152A2/en active Application Filing
- 2008-12-22 CN CN200880126952.0A patent/CN101970459B/zh active Active
- 2008-12-22 CA CA2709884A patent/CA2709884C/en active Active
- 2008-12-22 EP EP08865440.5A patent/EP2235041B1/en active Active
- 2008-12-22 SI SI200831210T patent/SI2235041T1/sl unknown
- 2008-12-22 RS RS20140287A patent/RS53326B/en unknown
- 2008-12-22 ES ES08865440.5T patent/ES2468250T3/es active Active
- 2008-12-22 JP JP2010538908A patent/JP5524858B2/ja active Active
- 2008-12-22 PT PT88654405T patent/PT2235041E/pt unknown
- 2008-12-22 PL PL08865440T patent/PL2235041T3/pl unknown
-
2014
- 2014-05-26 HR HRP20140466AT patent/HRP20140466T1/hr unknown
- 2014-06-03 CY CY20141100392T patent/CY1115239T1/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006086321A2 (en) * | 2005-02-09 | 2006-08-17 | Helix Biomedix Inc. | Antimicrobial hexapeptides |
Non-Patent Citations (3)
Title |
---|
Albumin Binding of Short Cationic Antimicrobial Micropeptides and Its Influence on the in Vitro Bactericidal Effect;Svenson,J et al;《Journal of Medicinal Chemisitry》;20070712;第50卷(第14期);第3334页,右栏最后1段第1-3行,第3335页,左栏第1段,以及图1 * |
Antimicrobial Peptides with Stability toward Tryptic Degradation;Svenson.J et al;《Biochemistry》;20080325;第47卷(第12期);第37777-3788页 * |
Application of the Suzuki–Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials;HAUG et al;《Bioorganic & Medicinal Chemistry Letters》;20070330;第17卷(第8期);第2361-2364页 * |
Also Published As
Publication number | Publication date |
---|---|
DK2235041T3 (da) | 2014-06-02 |
CA2709884A1 (en) | 2009-07-02 |
JP2011507822A (ja) | 2011-03-10 |
JP5524858B2 (ja) | 2014-06-18 |
GB0724951D0 (en) | 2008-01-30 |
CY1115239T1 (el) | 2017-01-04 |
PT2235041E (pt) | 2014-06-12 |
SI2235041T1 (sl) | 2014-08-29 |
AU2008339611B2 (en) | 2014-09-25 |
PL2235041T3 (pl) | 2014-08-29 |
EP2235041B1 (en) | 2014-03-05 |
US8598114B2 (en) | 2013-12-03 |
CA2709884C (en) | 2017-11-07 |
EP2235041A2 (en) | 2010-10-06 |
ES2468250T3 (es) | 2014-06-16 |
WO2009081152A3 (en) | 2009-09-24 |
CN101970459A (zh) | 2011-02-09 |
RS53326B (en) | 2014-10-31 |
HRP20140466T1 (hr) | 2014-07-18 |
AU2008339611A1 (en) | 2009-07-02 |
WO2009081152A2 (en) | 2009-07-02 |
US20110172145A1 (en) | 2011-07-14 |
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