CN1824289A - P物质用于间充质干细胞的动员或增殖以及用于伤口愈合或促进伤口愈合的用途 - Google Patents
P物质用于间充质干细胞的动员或增殖以及用于伤口愈合或促进伤口愈合的用途 Download PDFInfo
- Publication number
- CN1824289A CN1824289A CNA2005101380225A CN200510138022A CN1824289A CN 1824289 A CN1824289 A CN 1824289A CN A2005101380225 A CNA2005101380225 A CN A2005101380225A CN 200510138022 A CN200510138022 A CN 200510138022A CN 1824289 A CN1824289 A CN 1824289A
- Authority
- CN
- China
- Prior art keywords
- msc
- wound
- wound healing
- mobilization
- propagation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/046—Tachykinins, e.g. eledoisins, substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
上皮愈合时间(天) | 角膜不透明性 | 角膜新血管形成 | |
对照组(n=10) | 10.25±2.36 | 3.43±0.79 | 3.57±0.79 |
MSC IV(n=10) | 5.50±0.58* | 1.50±0.65* | 1.71±0.75* |
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040086359A KR100593397B1 (ko) | 2004-10-27 | 2004-10-27 | 중배엽 줄기세포 및/또는 p 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
KR1020040086359 | 2004-10-27 | ||
KR10-2004-0086359 | 2004-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1824289A true CN1824289A (zh) | 2006-08-30 |
CN1824289B CN1824289B (zh) | 2011-08-31 |
Family
ID=36013350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005101380225A Expired - Fee Related CN1824289B (zh) | 2004-10-27 | 2005-10-27 | P物质用于间充质干细胞的动员或增殖以及用于伤口愈合或促进伤口愈合的用途 |
Country Status (7)
Country | Link |
---|---|
US (2) | US8551470B2 (zh) |
EP (1) | EP1658855B1 (zh) |
JP (1) | JP5134772B2 (zh) |
KR (1) | KR100593397B1 (zh) |
CN (1) | CN1824289B (zh) |
AT (1) | ATE423565T1 (zh) |
DE (1) | DE602005012905D1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110732017A (zh) * | 2019-11-08 | 2020-01-31 | 中山大学 | Sp在制备用于治疗男性不育症的药物中的用途 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101374538A (zh) * | 2006-10-30 | 2009-02-25 | 吉诺米克斯股份有限公司 | 损伤组织的功能再生促进药物 |
KR20080068950A (ko) * | 2007-01-22 | 2008-07-25 | 경희대학교 산학협력단 | 골수 손상 예방 및 치료용 조성물 |
US8114668B2 (en) * | 2007-05-14 | 2012-02-14 | Cardiac Pacemakers, Inc. | Composition for cold storage of stem cells |
EP2178550A4 (en) * | 2007-07-27 | 2010-08-04 | Immuneregen Biosciences Inc | METHODS AND COMPOSITIONS FOR STIMULATING THE PROLIFERATION OR DIFFERENTIATION OF STEM CELLS BY SUBSTANCE P OR AN ANALOGUE THEREOF |
KR20090035279A (ko) * | 2007-10-05 | 2009-04-09 | 경희대학교 산학협력단 | 위장관 손상 예방 및 치료용 조성물 |
WO2009065093A2 (en) * | 2007-11-17 | 2009-05-22 | University Of Medicine And Dentistry Of New Jersey | Use of stem cells for wound healing |
KR20110017371A (ko) | 2008-04-30 | 2011-02-21 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
EP2301559A4 (en) | 2008-04-30 | 2012-05-02 | Genomix Co Ltd | RECRUITMENT AGENT FOR PLURIPOTENT STRAIN CELL FROM BONE MARROW IN PERIPHERAL CIRCULATION |
JP5814549B2 (ja) * | 2008-04-30 | 2015-11-17 | 株式会社ジェノミックス | 損傷組織の機能的再生促進医薬 |
KR101175175B1 (ko) | 2008-07-28 | 2012-08-20 | 서울대학교병원 | 인간 줄기세포에서 고활성 줄기세포를 분리하는 방법 및상기 방법에 의해 분리된 고활성 줄기 세포 |
KR101590558B1 (ko) * | 2009-03-06 | 2016-02-01 | 경희대학교 산학협력단 | P 물질을 이용한 뼈 형성제 및 그 제조방법 |
AU2010312537A1 (en) | 2009-10-28 | 2012-05-17 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
JP5852773B2 (ja) | 2010-06-01 | 2016-02-03 | ピアス株式会社 | 骨髄間葉系幹細胞の誘引剤の製造方法、骨髄間葉系幹細胞の誘引方法、及び、骨髄間葉系幹細胞の誘引剤を製造するための使用 |
JP2013528208A (ja) * | 2010-06-11 | 2013-07-08 | ユニバーシティ−インダストリー コーオペレーション グループ オブ キョン ヒ ユニバーシティ | サブスタンスpを用いた骨形成剤及びその製造方法 |
CA2834255C (en) | 2011-04-26 | 2021-11-02 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
MX365899B (es) | 2012-10-25 | 2019-06-19 | Univ Osaka | Composición farmacéutica que comprende un fragmento de péptido de hmgb1 para usarse en tratamiento de daño a la medula espinal. |
RU2647467C2 (ru) | 2012-10-25 | 2018-03-15 | Дженомикс Ко., Лтд. | Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 |
JP6113133B2 (ja) | 2014-11-06 | 2017-04-12 | 日本メナード化粧品株式会社 | 幹細胞の未分化状態維持剤及び増殖促進剤 |
KR20180102661A (ko) | 2016-01-21 | 2018-09-17 | 에이비티 홀딩 컴퍼니 | 상처 치유를 위한 줄기 세포 |
KR101825041B1 (ko) * | 2016-04-07 | 2018-02-02 | 주식회사 바이오솔루션 | 물질 p를 포함하는 상처치유용 약학 조성물 |
JP7182162B2 (ja) | 2017-01-27 | 2022-12-02 | 株式会社ステムリム | 心筋症、陳旧性心筋梗塞および慢性心不全の治療薬 |
JPWO2019107530A1 (ja) | 2017-12-01 | 2020-11-26 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
JP2022503847A (ja) * | 2018-09-27 | 2022-01-12 | バイオカーディア,インコーポレイテッド | 治療適用のための骨髄由来ニューロキニン-1受容体陽性(nk1r+)前駆細胞 |
KR102398968B1 (ko) | 2020-07-13 | 2022-05-17 | (주) 엘피스셀테라퓨틱스 | 조혈 줄기세포의 가동을 위한 물질-p의 배합 요법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616562A (en) | 1990-04-27 | 1997-04-01 | Murphy; Christopher J. | Methods and compositions using substance P to promote wound healing |
US5545617A (en) * | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
US5945508A (en) | 1996-07-23 | 1999-08-31 | Witten; Mark L. | Substance P treatment for immunostimulation |
ES2237089T3 (es) | 1998-03-13 | 2005-07-16 | Osiris Therapeutics, Inc. | Usos para celulas madre mesenquimatosas humanas no autologas. |
CA2418976C (en) * | 2000-08-10 | 2011-08-02 | Santen Pharmaceutical Co., Ltd. | Skin wound healing promoters |
JP4096115B2 (ja) * | 2000-08-10 | 2008-06-04 | 輝夫 西田 | 皮膚創傷治癒促進剤 |
WO2002102835A2 (en) | 2000-11-21 | 2002-12-27 | New England Medical Center | Novel antimicrobial compounds |
US6437093B1 (en) | 2000-11-28 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods of treatment comprising administration of Substance P |
WO2003015768A2 (en) * | 2001-08-16 | 2003-02-27 | Probiodrug Ag | Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades |
US7119071B2 (en) | 2002-05-21 | 2006-10-10 | University Of Medicine And Dentistry Of New Jersey | Amino terminal substance P compositions and methods for using the same |
AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
-
2004
- 2004-10-27 KR KR1020040086359A patent/KR100593397B1/ko active IP Right Grant
-
2005
- 2005-10-25 US US11/259,550 patent/US8551470B2/en active Active
- 2005-10-26 AT AT05023367T patent/ATE423565T1/de not_active IP Right Cessation
- 2005-10-26 EP EP05023367A patent/EP1658855B1/en not_active Not-in-force
- 2005-10-26 DE DE602005012905T patent/DE602005012905D1/de active Active
- 2005-10-27 CN CN2005101380225A patent/CN1824289B/zh not_active Expired - Fee Related
- 2005-10-27 JP JP2005313174A patent/JP5134772B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-05 US US14/018,772 patent/US9254305B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110732017A (zh) * | 2019-11-08 | 2020-01-31 | 中山大学 | Sp在制备用于治疗男性不育症的药物中的用途 |
Also Published As
Publication number | Publication date |
---|---|
US20140065109A1 (en) | 2014-03-06 |
EP1658855B1 (en) | 2009-02-25 |
EP1658855A3 (en) | 2006-05-31 |
CN1824289B (zh) | 2011-08-31 |
ATE423565T1 (de) | 2009-03-15 |
KR100593397B1 (ko) | 2006-06-28 |
KR20060037176A (ko) | 2006-05-03 |
DE602005012905D1 (de) | 2009-04-09 |
EP1658855A2 (en) | 2006-05-24 |
JP2006124389A (ja) | 2006-05-18 |
US9254305B2 (en) | 2016-02-09 |
JP5134772B2 (ja) | 2013-01-30 |
US8551470B2 (en) | 2013-10-08 |
US20060127373A1 (en) | 2006-06-15 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: KOREA ATOMIC POWER MEDICAL COLLEGE; APPLICANT Free format text: FORMER OWNER: KOREA ATOMIC ENERGY RESEARCH INSTITUTE; APPLICANT Effective date: 20081121 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20081121 Address after: Seoul, South Kerean Applicant after: Korean Academy of atomic force medicine Co-applicant after: Chung-Ang University Industry-Academy Cooperation Address before: Seoul City, Korea Applicant before: Korean Institute of atomic force Co-applicant before: Chung-Ang University Industry-Academy Cooperation |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110831 Termination date: 20171027 |
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CF01 | Termination of patent right due to non-payment of annual fee |