CN1819838A - 人类胰腺腺泡细胞体外扩增并转分化为胰岛素产生细胞的方法 - Google Patents

人类胰腺腺泡细胞体外扩增并转分化为胰岛素产生细胞的方法 Download PDF

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CN1819838A
CN1819838A CNA038170884A CN03817088A CN1819838A CN 1819838 A CN1819838 A CN 1819838A CN A038170884 A CNA038170884 A CN A038170884A CN 03817088 A CN03817088 A CN 03817088A CN 1819838 A CN1819838 A CN 1819838A
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cell
insulin
culture
culture medium
peptide
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S·C·普里斯耐尔
N·罗宾斯
M·赫达兰
P·哈兰德
P·P·拉塔
D·W·沙普
M·卡茨
C·麦金太尔
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Becton Dickinson and Co
Viacyte Inc
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Becton Dickinson and Co
Novocell Inc
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Abstract

本发明涉及例如扩增哺乳动物腺泡细胞的方法，包括在包含细胞培养基和细胞附着表面的细胞培养体系中培养细胞，条件是其中所述的腺泡细胞经过3－4倍的扩增并转分化为显示腺泡细胞和肝细胞特征的修饰的细胞表型(IP细胞)。本发明还涉及体外将这些IP细胞转化至胰岛素产生细胞的方法，包括在新的、限定的培养基中培养所述细胞。本发明还公开了适于进行这些方法的培养基、具有IP细胞表型和/或由这些方法产生的分离的细胞，以及完成这些方法的试剂盒。

Description

人类胰腺腺泡细胞体外扩增并转分化为胰岛素产生细胞的方法
本申请要求2002年5月28日提交的临时申请60/384,000的利益，其公开内容在此全部引入以供参考。
发明背景
1.发明领域
[0001]本发明涉及组合物和方法，借此例如人胰腺腺泡细胞在支持扩展和转分化为腺上皮细胞并随后转分化成胰岛素产生细胞的条件下培养。
背景技术
[0002]从器官供体取得胰岛素产生细胞并植入胰岛素依赖的I型糖尿病患者的潜在益处是很清楚的。在Edmonton临床试验中，在移植了来自器官供体来源的完整的胰岛的许多患者已经不用外源胰岛素递送存活了大约两年。但是，现有技术需要两个器官供体胰腺来产生足够量的胰岛(大约一百万个胰岛，每个由大约1000个细胞组成)移植入一个糖尿病患者用于细胞疗法。因此，糖尿病领域中的重点是鉴定用于移植的胰岛素产生细胞的新来源。尝试了许多方法，包括收获胰岛后并于移植前进行扩增以及从来自骨髓的干细胞样细胞或从位于胰腺的前体细胞产生新的胰岛。这些方法面临的问题是维持长时间培养后胰岛的功能，以及维持来自骨髓和胰腺的可以控制用于胰岛素产生的比较稀少的干细胞样细胞的功能。据报导来自胰腺的导管(ductular)前体干细胞样细胞比骨髓来源的细胞在分化为成胰岛素产生细胞上更有效，这可能反映了其来源位点(即胰腺)，在那里它们必然接触到许多有关胰腺微环境的分化信号。胰腺中最丰富的细胞种类是腺泡细胞，其占胰腺的约85％。腺泡细胞作用是产生和分泌消化酶并从导管细胞区室在发育过程中产生如胰岛细胞。
[0003]已经报导腺泡细胞在体外培养时，特别是在压力条件下，能进行“转分化”成类似导管细胞的细胞类型，如通过CK19、CK7和碳酸酐酶的表达所确定的(所有都被作者认为是导管细胞的标志)(Kerr-Conte，1996；WO02/29010 A2，Hall等人，1992)。另外，Bouwens等人(1998)已经表明在体内，在胰腺导管结扎模型中，在胰腺的结扎部分的腺泡细胞发生了转分化成具有导管表型的细胞。进一步的工作表明胰腺结扎部分的导管细胞的进一步的分化可以产生胰岛素产生细胞。也报导所述的腺泡细胞在初级培养中是有限存活的，某些培养条件导致一周内至少50％细胞的丧失。同时证明体外初级导管细胞在某些培养条件下转化成胰岛素产生细胞(例如Bonner Weir，2000，U.S.Pat.No.6,011,647)，没有报导说来自腺泡的细胞体外进一步分化产生胰岛样细胞。
[0004]在开发本体系之前，初级胰腺腺泡细胞在含有血清的培养基(由于与使用血清有关的危险性和不确定性而不合需要)中或在复杂无血清培养基制剂中都没有被扩增分化成胰岛素产生细胞。类似的，已经转分化为胰岛素产生细胞的胰腺腺泡细胞没有扩增，产生少量的具有胰岛素产生表型的细胞。而且，以前从不可能使用腺泡细胞作为原料获得大量的胰岛素产生细胞。
[0005]因此，需要简单的细胞培养体系和方法用于通过扩增和转分化丰富的胰腺腺泡细胞快速产生大量的能进一步分化为例如胰岛素产生细胞的细胞。而且，需要细胞培养体系和方法用于培养并转化该细胞为胰岛素产生细胞。此处公开的一种细胞培养体系和相关的方法可以简单地、一步法产生扩增的培养物，其含有至少80％的中间祖细胞，其能产生胰岛素产生细胞。另一种细胞培养体系和相关的方法可以进一步培养这些中间祖细胞和其它腺上皮细胞以获得胰岛素产生细胞。IP细胞和胰岛素产生细胞都将用于治疗如糖尿病等的疾病的基于细胞的疗法。发明简述
[0006]本发明提供了组合物和方法，由此例如腺泡细胞可以被成功的体外培养，经过一段时间细胞数目发生3-4倍的增加，并在培养的早期(离体2-3天)产生共表达腺泡和导管性标志的细胞群，然后最终(例如约离体7-8天)获得特征在于表达一些腺泡相关基因以及一些肝相关基因的修饰的表型。在约离体7-8天的这些修饰的细胞表达的基因包括例如导管细胞角蛋白(CK7、CK8、CK18和CK19)、肝核因子1(HNF1)、α-1抗胰蛋白酶、π-谷胱甘肽S转移酶(π-GST)、肝特异性(碱性螺旋-环-螺旋)(bHLH)转录因子、Thy-1、CCAAT/增强子结合蛋白(C/EBP)-α和C/EBP-β。这些细胞如果有也很少表达胰腺相关基因碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶。“如果有也很少”表达基因此处的意思是基因表达在常规方法(如此处所述的杂交和免疫细胞化学方法)下通常是检测不到的，但是表达可能被特别灵敏的方法(如基于PCR的分析)检测到。这种类型的修饰的细胞此处是指中间祖细胞(IP)。扩增的/转分化的腺泡细胞(IP细胞)可以使用通常的含有血清的培养基制备，或在优选的方法中，可以无需血清在一种或多种可溶性活性因子存在下在一个表面上制备，所述的表面包含一种或多种细胞外基质分子(ECM)。ECM可以在可溶性活性因子存在下存在于二维或三维培养体系中。
[0007]从该培养物产生的I P细胞可直接用于某些医学用途。例如，有证据表明该细胞当植入糖尿病患者中时可在某些条件下成为功能性胰岛素产生细胞。该细胞也可以用于药物开发和毒性研究。
[0008]另外，根据本发明的一个方面，IP细胞可以在无血清培养基中进一步培养，所述的无血清培养基由任何标准的无血清基础培养基(例如DMEM：HamsF12)和BSA以及因子的组合组成，包括ECM，小分子和生长因子。5-10天培养后，IP细胞进行另外的分化步骤，最后形成表达胰岛素原和C-肽的细胞聚合体。用高葡萄糖培养基攻击(challenge)该培养物导致胰岛素和C-肽释放到培养基中，这表明在这些培养物中产生了有功能的胰岛样细胞。
[0009]因此，本发明一方面提供了细胞培养体系，其包含也刺激细胞扩增的较好的细胞附着表面，以及简单的细胞培养基，所述的培养基包括在基础培养基组合物中加入有效量的一种或多种可溶性的活性因子或血清(例如胎牛血清)。所述的细胞培养体系将对哺乳动物上皮细胞的初级培养特别有用，特别是人上皮细胞。在优选的实施方案中，所述的细胞培养体系用于扩增和转分化初级腺泡细胞，特别是人胰腺腺泡细胞。
[00010]用于所述的细胞培养体系的细胞附着表面是细胞可以附着并扩增的任何表面，既包括二维(例如平板、烧瓶、滚瓶、培养皿、孔等)也包括三维(例如支架)环境。优选的表面包含至少一种ECM，或其肽片段。在某些情况中，细胞可能从这些表面脱落并形成自我支持的聚合体。合适的片段包括由与ECM的氨基酸序列的任何部分相同的三个或多个氨基酸残基的序列组成的肽。所述的片段可以通过本领域技术人员已知的方法容易的制备并检测。最优选地，所述的表面是胶原I的层。许多其它本领域已知的表面也适合，如胶原VI、胶原IV、玻连蛋白或纤连蛋白。由于容易和便宜胶原I是优选的。
[00011]加入可溶性活性因子的基础培养基可能是适于上皮细胞生长和分化的任何细胞培养基。其包括但不限于DMEM、Hams12、MEM、M-199和RPMI。本领域技术人员已知这些培养基的基本要求和许多合适的实例。向这些基础培养基中加入血清(例如胎牛血清)或稳定蛋白质如牛血清白蛋白(BSA)以及有效量的可溶性活性因子。该培养基优选无血清的。
[00012]用于初级胰腺腺泡细胞扩增并转分化为IP细胞的可溶性活性因子包括生长因子如HGF受体活化剂和EGF受体活化剂。优选的可溶性活性因子包括一种或多种EGF和转化生长因子-α、IGF1、HGF、β动物纤维素(betacellulin)、催乳素和胃泌素1。HGF、EGF和/或转化生长因子-α是特别优选的。还优选IGF1和β动物纤维素的组合。
[00013]在一个特别优选的实施方案中，基础培养基包含DMEM和Hams F12的1∶1混合物。在基础培养基中加入下列物质进行完善：终浓度为～4mM的谷氨酰胺，胰岛素(～0.1-10μg/ml、优选～0.01mg/ml)、转铁蛋白(～0.5-10μg/ml、优选～0.0055mg/ml)、硒(～0.25-5.0ng/ml、优选～0.00067μg/ml的亚硒酸钠)和表皮生长因子(EGF)(～1-20ng/ml、优选～10ng/ml)；以下称该培养基为胰腺细胞培养基或PCM。可以向该基础培养基制剂中加入多达～20％胎牛血清(或其它血清)，优选～10-～15％的胎牛血清，最优选约10％或多达约15％的胎牛血清，或者为了创造无血清培养环境，加入下列组分取代血清：热失活的牛血清白蛋白(0.1-2％)、肝细胞生长因子(HGF)(1-20ng/ml)和/或转化生长因子α(1-10ng/ml)。另外，该培养基可能包含β动物纤维素(betacellulin)(0.5-20ng/ml)、胃泌素1(0.05-10ng/ml)、催乳素(1.0-10ng/ml)和/或IGF1(5-100ng/ml)。在具体的制剂中，可能加入较多或较少量的这些组分以获得有效支持细胞扩增和转分化的制剂。本领域技术人员将理解仅需要常规试验就可确定组分的有效量。
[00014]使用所述的附着表面和培养基大大简化了具有所需表型的初级胰腺细胞的扩增和转分化。
[00015]在特别优选的实施方案中，细胞培养体系是胶原I包被的组织培养表面(呈现为2维或3维形式)和含有BSA、胰岛素、转铁蛋白、硒、肝细胞生长因子(HGF)、表皮生长因子(EGF)和转化生长因子α(TGFA)的无血清培养基的组合。
[00016]与现有的方法相比，所述的细胞培养体系使贴壁培养的初级胰腺上皮细胞体外很好的附着，同时创造了促进初级胰腺培养物的上皮组分的扩增的细胞环境，伴有在原材料中的腺泡细胞转分化为IP细胞，而最小化不需要的成纤维细胞的出现。该培养体系的优点使容易构建，需要较少的组分并且所有的组分都容易获得并容易以所需的形式使用。
[00017]本发明这方面的组分可方便地包装成试剂盒的形式。所述的试剂盒可包括，例如，1)细胞培养基如DMEM，2)无血清培养基添加物，包含BSA、胰岛素、转铁蛋白、硒、HGF、EGF和TGFA，以产生上述完全培养基中所示浓度的合适的量；和3)至少一种胶原I包被的基质，如用于组织培养的器皿(例如具有至少一种胶原I包被的组织培养表面的培养皿)或胶原I包被的插入物用于培养皿或其它实验室器皿。该试剂盒还可能任选的包括组织培养皿或其它细胞培养辅助设备和另外的进行上皮细胞培养和分化所需的试剂。
[00018]由支架、胶原包被的烧瓶或其它器皿和无血清基础培养基组成的培养体系可以与可溶性活性因子包装成单独的小瓶，其可在使用前加入到培养基中。活性因子的组合可以被加入多种基础培养基中以实现相同的目的，例如初级胰腺腺泡细胞的体外生长和分化。该培养体系必须还对其它细胞类型有用，特别是来自其它器官和组织的腺上皮细胞，包括来自肝、胰腺、肠、前列腺和乳房的细胞。
[00019]胶原I表面提供了很好的细胞附着(由此增加在初始培养中贴壁的细胞数并因此增强培养效率)，而胶原I和可溶性活性因子组合(例如HGF、TGFA和EGF)促进了细胞随时间的继续的增殖，导致细胞数增加超过以前报导的初级胰腺腺泡细胞数。另外，腺泡细胞的扩增伴随大多数细胞转分化为IP表型，其为潜在的治疗用细胞表型用于治疗如糖尿病等疾病。这可能是由于细胞内与胶原I、HGF、TGFA和EGF有关的信号传导途径的汇聚，产生了协同反应。
[00020]本发明的细胞培养体系与以前应用的体系相比具有意料不到的优点。预料胶原I、IV、VI、玻连蛋白和纤连蛋白增强了细胞附着。但是，在培养的初始18个小时期间产生等同的细胞附着的其它细胞外基质分子在含有HGF/EGF/TGFA的无血清培养基中没有促进细胞随时间的一致的生长。最有效和最经济的获得细胞扩增和分化为IP细胞的方法是利用胶原I表面和含有减少血清的培养基(优选少于20％，更优选少于15％、10％或5％，最优选2％)。
[00021]本发明的另一方面是用于培养哺乳动物上皮细胞的方法，包括将所述细胞加入上述的细胞培养体系中，并将其维持在合适的温度和气体条件。“哺乳动物上皮细胞”是指具有上皮细胞表型的任何组织或器官的细胞，由存在细胞角蛋白的表达和经常通过存在表明组织特异性功能(例如皮肤上皮细胞产生角蛋白，肠上皮细胞产生粘蛋白，前列腺上皮细胞产生PSA)的标志的存在所确定。在优选的实施方案中，细胞为初级胰腺细胞，特别是人胰腺细胞。对于哺乳动物细胞合适的温度通常在约37℃的范围内，但是可以根据细胞类型进行一定程度的变化。气体可以是普通的空气，或其它适于维持细胞的气体的特定混合物，其对于本领域技术人员来说是熟知的。通过将培养气体中的氧压力降低至小于21％可以最大化胰腺腺泡细胞的扩增，而通过将氧压力增加至大于5％可以增强向IP细胞的转分化。优选的氧压力为约5％-约21％。
[00022]本发明的另一方面还提供了用于将如上所述已经获得中间祖细胞(IP)表型特征的标志表达的腺上皮细胞转化为胰岛素产生细胞的方法和组合物。“腺上皮细胞”是指是腺体组分的上皮细胞。腺体是具有与分泌重要的分子相关的特定功能的组织-体内的大多数器官具有腺体的功能(肝、肠、前列腺、胰腺、乳房、垂体、肾上腺、肾)，由此其产生和释放激素、消化酶或其它生命必须的液体。来自内胚层来源的器官的腺上皮细胞(例如肝、肠、胰腺)具有许多共有的特征，包括表达许多相同基因的能力。特别优选的腺上皮细胞来自胰腺，例如腺泡细胞。此处所用的术语“表达”通常是指通过标准的免疫细胞化学方法可检测的核酸(如mRNA)或蛋白质基因产物。
[00023]本发明的这方面提供了另一种细胞培养体系，其包含支持和促进腺上皮细胞转化为胰岛素产生细胞的细胞附着表面和培养基。所述的细胞附着表面与用于扩增初级胰腺腺泡细胞的附着表面类似并可能相同。其可能为包被在器皿上的平表面形式或支架的形式或其它适于细胞培养的表面。其可以由能维持细胞或支持细胞生长的任何组分组成或包被。在优选的实施方案中，其包含至少一种ECM，如胶原I、胶原VI、胶原IV、玻连蛋白或纤连蛋白。在特别优选的实施方案中，细胞附着表面是胶原I。
[00024]本发明的这一方面提供了进一步的培养基，其包含至少一种分化促进因子(“DPF”)，所述的分化促进因子促进腺上皮细胞分化为胰岛素产生细胞。用于腺上皮细胞转化为胰岛素产生细胞的DPF可以是活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚单位、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-1)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、催乳素、Sonic Hedgehog、P物质、TGFα、Trolox(α生育酚衍生物)或VEGF中的一种或多种。这23种DPF在培养基中的优选浓度列于表1。尽管在某些情况一种DPF已经足够，但是优选使用两种或多种因子。可使用多至所有23种因子。
表1
  物质   浓度(微克/mL)
  活化素A(人，重组的)   0.0005
  CGRPα，(降钙素基因相关肽，大鼠)   0.1905
  C钠尿肽(人，猪，大鼠：frag 32-53)(CNP)   0.10985
  霍乱毒素B亚单位，重组   0.0125
  地塞米松(9α-氟-16α-甲基脱氢皮质甾醇)(氢化可的松类似物)   0.002
  酸性FGF(aFGF＝FGF1)，重组，人   0.0025
  GLP-1(7-36)酰胺，人(胰高血糖素样肽1)   0.033
  葡萄糖(碱性必须低；0.9ug/ml)   1.08
  胰岛素，人(低，在基础培养基中1ug/ml)   9.5
  LIF，人(白血病抑制因子，人)   0.0025
PDGF AA+PDGF BB MIX   0.005
  TGFα   0.001
  催乳素(人，重组)(血浆生长激素)   0.0012
  Trolox(可溶性维生素E)(C14H18O4)   0.625
  GRP(胃泌素释放肽，人)   0.143
IGF-1，重组人 0.0025
IGF-2，重组人 0.0025
层粘连蛋白 2.25
Met-脑啡肽(tyr-gly-glyl-phe-met) 0.003
Sonic Hedgehog(鼠，重组) 0.025
  P物质(全长)(H1875是frag1-4)   5
  FGFb(＝FGF2)，人重组   0.0025
  VEGF   0.0025
[00025]在本发明这方面优选的实施方案中，所述的培养基包含至少一种(或多达所有10种)下列分化促进DPF：C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚单位、地塞米松、胃泌素释放肽、层粘连蛋白、Met-脑啡肽、PDGFAA+PDGFBB、Sonic Hedgehog和P物质。
[00026]在优选的实施方案中，所述的促进腺上皮细胞转化为胰岛素产生细胞的培养基由DMEM和Hams F12的1∶1混合物加表2中所列的组分组成的。该培养基有时称为“培养基G9”。
表2
  因子   物质   终浓度(ug/ml)
  1   ANP   心房肽，大鼠(28氨基酸)   0.1530
  2   CCK-8-frag-酰胺   CCK8，片段26-33酰胺(缩胆囊素)(Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2)   0.0250
  3   硫酸雨蛙肽   雨蛙肽(Pyr-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2)   0.0030
  4   霍乱毒素-B   霍乱毒素B亚单位，重组   0.0125
  5   Dex   地塞米松(9α-氟-16α-甲基脱氢皮质甾醇)(氢化可的松类似物)   0.0020
  6   FGF-7   FGF7(KGF)   0.0025
  7   GLP-1   GLP-1(7-36)酰胺，人(胰高血糖素样肽1)   0.0330
  8   GRP   GRP(胃泌素释放肽，人)   0.1430
  9   胃泌素-1   胃泌素-1，人   0.0000
  10   葡萄糖   葡萄糖(碱性必须低；0.9ug/ml)   1.0800
  11   HGF   肝细胞生长因子(HGF)重组   0.0025
  12   IGF-1   IGF-1，重组人   0.0025
  13   IGF-2   IGF-2，重组人   0.0025
  14   胰岛素   胰岛素(低，在基础培养基中1ug/ml)   9.5000
  15   Leu-脑啡肽   Leu-脑啡肽(tyr-gly-gly-phe-leu)   0.0030
  16   烟酰胺   烟酰胺   610.0000
  17   PTHRP-frag-1-34   pT II RP(甲状旁腺激素相关肽(1-34)，人)   0.2060
  18   孕酮   孕酮   0.0030
  19   催乳素   催乳素(人，重组)(血浆生长激素)   0.0012
  20   乙酸视黄醇酯   视黄酸(维生素A)   0.0250
  21   SHH   Sonic Hedgehog(鼠，重组)   0.0250
  22   亚硒酸钠   硒(硒酸，钠盐)   0.0250
  23   大豆胰蛋白酶抑制剂   胰蛋白酶抑制剂，大豆(型I-S)   0.5000
  24   TGF-βsRII   TGF-βsRII(可溶性受体型2)   0.0050
  25   转铁蛋白   转铁蛋白   2.7500
  26   Trolox   Trolox(可溶性维生素E)(C14H18O4)   0.6250
  27   VIP   血管活性肠肽(VIP)，人   0.0665
  28   aFGF   酸性FGF(aFGF＝FGF1)重组人   0.0025
  29   bFGF   FGFb(＝FGF2)，人重组   0.0025
  30   正丁酸   正丁酸，钠盐   4.5450
[00027]本发明这方面的组分也可以方便地包装为试剂盒的形式。所述的试剂盒可包括，例如，1)细胞培养基如DMEM、Hams F12或其组合；2)无血清培养基添加物，包含BSA和DPF活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚单位、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-1)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、催乳素、Sonic Hedgehog、P物质、TGFα、Trolox(α生育酚衍生物)或VEGF，或这些组分的两种或多种的组合，以在完全培养基中产生表1所示的浓度的合适的量；和3)具有至少一种胶原I包被的组织培养表面的组织培养皿，(或胶原I包被的插入物用于培养皿或其它实验室器皿)。该试剂盒还可能任选的包括组织培养皿或其它细胞培养辅助设备和另外的进行上皮细胞培养和分化所需的试剂。在其它实施方案中，该试剂盒可能包含此处所述的任何培养基或培养基组分。
[00028]由支架、胶原包被的烧瓶或其它器皿和无血清基础培养基组成的培养体系可以与DPF包装成单独的小瓶，其可在使用前加入到培养基中。PDF组合可以被加入多种基础培养基中以实现相同的目的，例如初级胰腺腺泡细胞的体外生长和分化。该培养体系还可对其它细胞类型有用，特别是来自腺组织的其它上皮细胞，包括来自肝、胰腺、肠、前列腺和乳房的细胞。
[00029]本发明还提供了用于将腺上皮细胞转变成胰岛素产生细胞的方法，包括在上述的细胞培养体系中培养腺上皮细胞。该方法可进一步包括从细胞培养物中移去培养基，用具有葡萄糖和无血清培养基再饲养该细胞培养物，并测定胰岛素原产生C-肽产生或胰岛素释放。
[00030]另外，本发明提供了包含具有免疫可检测的胰岛素原、胰岛素和/或c-肽的细胞质颗粒的胰岛素产生细胞的分离的群体，其来自其中一种细胞亚型表达至少一种IP细胞相关的标志的细胞群(例如表达某些腺泡相关的基因以及肝相关基因，包括例如导管细胞角蛋白(CK7、CK8、CK18和CK19)、HNF1、α-1抗胰蛋白酶、π-谷胱甘肽S转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β，和如果有也很少表达的胰腺相关基因碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶)。
[00031]“分离的”细胞或细胞群此处是指所述的细胞或细胞群从其原始的环境(例如如果其是天然存在的则为其天然环境)中移开，与至少一种与其天然相关的其它组分分离或分开。例如，存在于其天然生活宿主的天然存在的细胞不是分离的，但是该细胞如果从一些或所有的天然体系中的共存物质中分离，则为分离的细胞。该细胞或细胞群可能是细胞培养物或细胞群的一部分，如果该培养物或群不是其天然环境的一部分，其仍然是分离的。
[00032]在一个优选的实施方案中，所述的胰岛素产生细胞来自获自哺乳动物胰腺的腺上皮细胞，如初级腺泡细胞。
[00033]下面实施例所示的数据产生自新鲜分离的人胰腺细胞。在这些条件的初级人胰腺细胞的扩增产生具有混合的上皮IP表型的培养物，适于多种目的的IP细胞的体外研究，并适于体内移植用于治疗如糖尿病等疾病的细胞疗法。这些方法产生的IP细胞也可能用于胰腺细胞生物学研究，作为研究胰腺上皮癌症的正常对照，并用于检测药物/化合物对正常胰腺上皮细胞(导管或腺泡)的影响。另外，如下所述，该细胞可能被进一步培养以产生胰岛素产生细胞。
附图简述
[00034]图1A-D显示了原料用淀粉酶抗体(图1A)、胰岛素抗体(图1B)、和CK19抗体(图1C)处理后的显微图象和新鲜分离的初级人胰腺细胞的细胞沉淀的组成。
[00035]图2显示生长于商品化培养基(带有血清)或于含有血清的所述的胰腺细胞培养基(PCM)中的初级人胰腺培养物的生长曲线。
[00036]图3显示在基础培养基+可溶性生长因子(无血清制剂)和基础培养基+胎牛血清的基础培养基组合物中细胞扩增的比较。
[00037]图4A-B显示了不同的培养表面对扩增后的总细胞数(图4A)和细胞表型(图4B)的影响。
[00038]图5A-B显示了在含有所有可溶性活性因子的含有血清的(5A)和无血清(5B)的培养基中扩增后的细胞表型的比较。
[00039]图6显示在不同条件扩增的细胞培养物的高倍图象，包括补加3中可溶性活性因子HGF、EGF和TGFA的无血清基础培养基。注意到上皮形态。
[00040]图7显示了IP细胞在ECM包被的表面上的生长，如随时间的代谢活性测定所确定。注意到当胶原I表面与此处所述的培养基制剂组合时的好的生长，产生的结果优于Matrigel和具有血清的商品化培养基的组合。
[00041]图8A(上左)显示了培养两天后腺泡细胞的淀粉酶的表达(红色染色)，图8B(下左)显示了CK19的表达(绿色染色)，图8C(右)显示了两个图象的重叠，显示大部分细胞中的共表达(黄色)。
[00042]图9显示在5天培养中初级腺泡细胞的表型改变。淀粉酶是红色的，CK19是绿色的。注意在第2天和第3天的黄色出现(淀粉酶+CK19)。
[00043]图10A和图10B显示了在含有血清的培养基中于胶原包被的表面上扩增的初级人胰腺细胞。分析图象确定总细胞(图10A，蓝色核)和总阳性细胞(图10B，蓝色核包围着绿色的CK19染色)。
[00044]图11显示了在胶原I表面用所有DPF培养的胰腺腺泡细胞的光学显微(200×)外观(活化素A，0.5ng/ml；酸性FGF，2.5ng/ml；碱性FGF、C-钠尿肽(CNP)，0.11μg/ml；降钙素基因相关肽，0.19μg/ml；霍乱毒素B亚单位，12.5ng/ml；地塞米松，0.002μg/ml；胃泌素释放肽，0.143μg/ml；胰高血糖素样肽-1(GLP-1)，0.033μg/ml；葡萄糖，1.08μg/ml；IGF1，0.0025μg/ml；IGF2，0.0025μg/ml；胰岛素，9.5μg/ml；层粘连蛋白，2.25μg/ml；LIF，0.0025μg/ml；Met-脑啡肽，0.0030μg/ml；PDGFAA+PDGFBB(0.0050μg/ml：0.0025μg/ml PDGFAA+0.0025μg/ml PDGFBB)；催乳素，0.0012μg/ml；、Sonic Hedgehog，0.025μg/ml；P物质，5.0μg/ml；TGFα，0.001Cμg/ml；Trolox(α生育酚衍生物)，0.625μg/ml；和VEGF，0.0025μg/ml)。
[00045]图12A(上面右图)显示了用CK19抗体的免疫细胞化学分析(绿色)。
[00046]图12B(下面右图)显示利用C-肽抗体的免疫细胞化学分析(红色)。
[00047]图12C(左图)显示了表明CK19和C-肽共定位(橙色)的重叠图。蓝色部分是DAPI染色的核。
[00048]图13A显示了在生长和分化过程中没有经脱附和再固定(传代培养)的IP细胞对于葡萄糖攻击的胰岛素释放。
[00049]图13B显示了根据实施例10的经传代培养的IP细胞对于葡萄糖攻击的胰岛素释放。
[00050]图13C显示了根据实施例10的没有经传代培养的IP细胞对于葡萄糖攻击的C-肽释放。
[00051]图14显示了在用DFP组合1、2和3培养基处理的传代和非传代培养细胞中的胰岛素/DNA比例，如实施例11所述。
[00052]图15显示了响应基础水平的葡萄糖(5mm)和葡萄糖攻击(22mm)10天的PCM和DMG9培养基中培养物的胰岛素释放，如实施例13所述。
[00053]图15A显示了响应基础水平的葡萄糖(5mm)和葡萄糖攻击(22mm)14天的PCM和DMG9培养基中培养物的胰岛素释放，如实施例14所详细描述。
[00054]图16是表6中所示的如表的最后一栏所述的、实施例14详细描述的17类基因的特征图示。
发明详述
[00055]在描述本发明的优选实施方案时，为清楚的原因使用特定的术语。但是，本发明不受限于所选择的特定的术语。应该理解每一具体的元素包括所有的技术等价体，其以相同的方式运作实现相同的目的。此处所应用的每一文献引入以供参考，即所有都独立引入以供参考。
[00056]使用下列的缩略语：
BSA：牛血清白蛋白
BMP：骨形态发生蛋白
bHLH：碱性螺旋-环-螺旋
DMEM：Dulbecco’s Modified Eagle’s Medium
TGFβ1：转化生长因子β1
ECM：细胞外基质分子，由组织的细胞产生的天然存在的蛋白质，提供结构上的支持以及附着相关的细胞信号原。实例有胶原、玻连蛋白、纤连蛋白和层粘连蛋白。
EGF：表皮生长因子
Hams F12：Ham’s Nutrient Mixture F12
HGF：肝细胞生长因子
HNF-1：肝核因子1
IGF1：胰岛素样生长因子1
IGF-II：胰岛素样生长因子2
IP细胞：来自上皮细胞如胰腺腺泡细胞或肝细胞，的中间祖细胞，其中该衍生的细胞表达某些腺泡相关的基因，以及某些肝相关的基因，包括例如细胞角蛋白(CK7，CK8，CK18和CK19)、HNF1、α-1抗胰蛋白酶、π-谷胱甘肽S转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β，并如果有也很少表达的胰腺相关基因碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶。
PDGF-A：血小板源性生长因子α
PDGF-B：血小板源性生长因子β
TGFA，TGF-α：转化生长因子α
[00057]此处所用的术语“培养体系”是指用于生长和/或分化培养中的细胞的体系，其包含细胞附着表面，优选一种也刺激细胞扩增的表面，以及培养基，所述的培养基中包含有效量的一种或多种因子，或血清(例如胎牛血清)，加入到基础培养基组合物中。
[00058]当此处提到活性可溶性因子时，“有效量”是指单独或与其它所含的因子组合有效促进扩增和分化为IP细胞或为胰岛素产生细胞的可适用的量。
                        实施例
I.初级腺泡细胞扩增和转分化为腺上皮细胞(培养阶段I)
材料和方法
[00059]原料：从标准COBE梯度制备用于移植的胰岛细胞作为废物收集初级人胰腺腺泡细胞(Lake等人，1989)。密度梯度离心后，胰岛存在于1.063密度和1.10密度之间的层，其它细胞以沉淀至基于密度的梯度的底部的沉淀收集。在移植中心收集细胞后大约48小时，发明人将其置于非组织培养处理的聚苯乙烯培养瓶并以大约2.0百万细胞/ml的密度悬浮在RPMI+10％胎牛血清中。通过台盼蓝排除和光学显微观察于血细胞计数器上计数来评价细胞数和存活力。
[00060]原料的表型评价。在初步收集胰腺细胞后约24小时福尔马林固定原料制剂并石蜡包埋细胞沉淀。制备石蜡切片，置于玻片上，用胰岛素抗体(Biogenex，San Ramon，CA)、CK19抗体(Biogenex)和淀粉酶抗体(Biogenex)进行免疫细胞化学分析。用每个标志评价每一样品的最少(3)个切片。所有的抗体染色根据制造商的建议利用预稀释的商品化抗体进行。对于CK19，用胃蛋白酶(Biogenex)处理3分钟，然后进行封闭来进行抗原回收。简言之，通过分级乙醇再水合切片，然后在没有钙和镁的磷酸缓冲盐水(PBS)中温育15分钟。在加入初级抗体前加入蛋白阻断剂(Biogenex)30分钟。(3)次5分钟洗涤后，以1∶100稀释度加入生物素化的二抗(Biogenex)，切片在室温温育30分钟。(3)次5分钟洗涤后，加入Alexa488或Alexa-596-缀合的链霉亲和素(Molecular Probes，Eugene，Oregon)进行荧光显色。对于每一玻片，使用配备有SPOT照相机的Nikon荧光显微镜(Diagnostic Systems，Inc，Webster，TX)最少捕获(3)200×图象。使用图象分析软件(MetaMorph/Universal Imaging Corporation，Downington，PA)定量评价该图象以确定胰岛素阳性、CK19+和淀粉酶+细胞的相对比例。胰岛素+细胞是胰岛的β细胞，CK19+细胞是初级导管细胞，淀粉酶+细胞是腺泡细胞(参见实施例1)。
实施例1：细胞培养条件的特征
A.无血清培养基
[00061]从COBE细胞分离器以沉淀收集新鲜分离的初级人胰腺细胞，福尔马林固定，石蜡包埋，切片并用淀粉酶、CK19和胰岛素的抗体分析。在Universal Imaging System(Universal Imaging Corporation)上收集图象(图1A和1B)，并用MetaMorph Software分析。该细胞沉淀(图1C)由1.0％的胰岛素+细胞(胰岛的β细胞)、5.8％CK19+细胞(初级导管细胞)和93.2％的淀粉酶+细胞和未标记的细胞(腺泡细胞和其它细胞类型)组成。
[00062]然后以104或105细胞/cm2将初级人胰腺细胞接种在组织培养处理的聚苯乙烯上，于DMEM商品化培养基+10％胎牛血清或于PCM+10％胎牛血清中。以3天的间隔通过胰蛋白酶消化收获一式两份的培养物，用血细胞计数器计数活细胞(通过台盼蓝排除确定的)。结果(图2所示)表明对于初级胰腺细胞的生长和维持而言此处所述的(含有血清)的培养基制剂优于商品化的培养基制剂。图3比较了在基础培养基、基础培养基+所有的可溶性活性因子[HGF，～1-～20ng/ml，优选～5.0ng/ml；TGFA，～1-～10ng/ml，优选～2ng/ml；β动物纤维素(betacellulin)，～0.5-～20ng/ml，优选～10ng/ml；胃泌素1，～0.05-～10ng/ml，优选～0.06ng/ml；催乳素，～1.0-～10ng/ml，优选～2.4ng/ml和IGF1，～5-～100ng/ml，优选～5ng/ml]和基础培养基+10％血清中细胞扩增6天的结果。无血清培养基制剂满足/胜过培养基+血清提供的扩增。
[00063]基本如上重复了细胞扩增试验，除了所述的基础培养基只补加了三种可溶性活性因子：TGF、HGF和EGF。图6D比较了在不同培养基中的细胞扩增结果；图6A、6B和6C显示了在不同培养基条件下扩增的细胞培养物的高倍图象。
B.ECM表面
[00064]通过计数在含有胶原I(1μg/cm2)、纤连蛋白(3μg/cm2)、层粘连蛋白(2μg/cm2)、玻连蛋白(1μg/cm2)、Matrigel(1μg/cm2)、人ECM(1μg/cm2)或聚-D-赖氨酸(3μg/cm2)的一组ECM表面上贴壁细胞数和原始接种的细胞数评价初级人胰腺细胞的附着。在一种条件下，使用胶原IV、层粘连蛋白和纤连蛋白的混合物。将以上浓度的ECM置于溶液中，并使其包被组织培养处理的聚苯乙烯表面，根据制造商的建议室温1小时。然后移去多余的ECM溶液，用水洗涤表面两次。接种细胞前，吸去水，然后将细胞以1×105细胞/cm2的密度接种在生长培养基中ECM表面上，生长培养基(PCM)由加有4mM谷氨酰胺、1×ITS添加物(GIBCO 51500-056)、10％胎牛血清(Inactivated，Qualified，GIBC 26140-079)和10ng/ml表皮生长因子(EGF)(BD4001)的DMEM：HsmsF12的混合物(1∶1)组成。将细胞接种在组织培养聚苯乙烯表面作为对照。18小时后，将未贴壁的细胞洗去，保留的贴壁细胞用PCM再饲养，使其生长7天，然后评价。用10％福尔马林固定培养物，用CK19和淀粉酶的抗体如前所述进行免疫细胞化学分析确定表型组成。用DAPI荧光蓝核染色对细胞进行复染以显示用于细胞计数的单独的细胞核。利用MTS测定确定进行不同条件的细胞的代谢活性。MTS测定用于测量存活的细胞(Promega CellTiter 96 Aqueous One Solution CellProliferation Assay)，MTS是一种确定增殖或细胞毒性中的活细胞数的比色法。该分析的结果如图7所示。
实施例2：用ECM表面和不同的培养基组分的进一步研究
[00065]由＞90％的非胰岛/非导管细胞组成的初级胰腺细胞以28900细胞/孔(105细胞/cm2)接种到不同的包被表面上。18小时后洗去未贴壁的细胞，再饲养培养物并使其生长8天。用福尔马林(10％)固定培养物并用CK19和淀粉酶的抗体进行表型分析。结果如图4A-B所示。尽管胶原I、IV、层粘连蛋白、纤连蛋白和Matrigel提供了细胞附着和扩增的合适的表面，但是随着增加比例的具有腺上皮表型(CK19+)的细胞的出现腺泡(淀粉酶+)表型的维持在胶原I上较好。超过50％的分析的细胞表达淀粉酶和超过50％的分析的细胞表达CK19，这表明在该试验条件中的细胞亚群表达两种标志。
[00066]如上所述用胶原I包被组织培养处理的聚苯乙烯培养表面。如上所述制备组织培养基(PCM)。在某些情况下，用级分V BSA(99％纯，热失活的，Sigma)代替血清，连同可溶性生长因子的组合，包括IGF1、IGF2、β动物纤维素、HGF、EGF、和TGFα。最佳的接种密度为104-105细胞/cm2，如实施例3所述。以1.5×106细胞/瓶的密度将细胞接种于胶原包被的培养瓶(150cm2)的PCM中。大约18小时的贴壁期后，通过轻柔的吸取/冲洗洗去未贴壁的细胞，然后用新鲜培养基再培养。通过代谢测定(MTT)和胰蛋白酶消化和细胞计数随时间监测培养物，确定细胞数(参见实施例3)。培养结束时细胞表型如下评价：同时将小份培养物置于96孔板中。在培养阶段结束时，用10％福尔马林固定单层细胞至少1小时。移去福尔马林后，冲洗单层细胞，培养物如上所述进行CK19、淀粉酶、胰岛素和波形蛋白(成纤维细胞的标志)的免疫细胞化学分析。通过如上所述的定量图象分析(参见实施例4)确定CK19+细胞的相对比例。移去福尔马林后，冲洗单层细胞，培养物如上所述进行CK19、淀粉酶和波形蛋白(成纤维细胞的标志)的免疫细胞化学分析。细胞也用淀粉酶抗体染色，但是没有产生由于培养一段时间的细胞释放消化酶如淀粉酶导致的阳性结果。通过如上所述的定量图象分析(参见实施例4)确定CK19+细胞的相对比例。通过证明在培养2-3天的细胞亚群中CK19和淀粉酶的共表达验证获得了腺泡细胞的导管标志(参见实施例5)。对于这些试验，CK19初级抗体与福尔马林固定的细胞培养物反应，然后用Alexa488缀合的山羊抗小鼠IgG(Molecular probes)显色。然后，细胞进行封闭(Protein Blocker，BioGenex)，然后加入第二初级抗体(抗淀粉酶)。通过加入Alexa594缀合的山羊抗小鼠IgG显色淀粉酶。如上所述收集图象。在上述条件的7天培养期结束时，培养物中65-90％的细胞表达CK19，而低于20％的细胞表达波形蛋白(参见实施例6)。CK19细胞的相对比例的变化可能反映了个体患者的年龄、性别和其它独特特征的异质性。
实施例3：细胞接种的密度
[00067]以(3)种密度将初级胰腺细胞接种于组织培养处理的聚苯乙烯培养皿(60mm)中，用PCM培养。每天进行光学显微镜观察。在24小时的时间点，处理培养皿，用台盼蓝染色评价存活力。结果如表3所示。
表3
  接种密度   于24小时  于48小时   3天生长后
  104细胞/cm2   大多数细胞附着，台盼蓝阴性(活)  有丝分裂象呈现(光学显微镜)   上皮单层形成
  105细胞/cm2   大多数细胞附着，台盼蓝阴性(活)  有丝分裂象呈现(光学显微镜)   上皮单层形成
  106细胞/cm2   一些细胞附着，大多数台盼蓝阳性(死活)  几乎没有有丝分裂象呈现(光学显微镜)   细胞脱落；一些成纤维细胞呈现
[00068]实施例4。细胞生长于37℃、21％氧气的PCM培养基或加入2％BSA、2ng/ml TGF-α、10ng/mlEGF和10ng/mlHGF的基础培养基中的胶原I表面。7天后，用10％福尔马林固定培养物，并利用荧光检测进行免疫细胞化学分析，然后自动图象收集和分析。结果如图5A和5B所示。成纤维细胞(波形蛋白+)部分、腺上皮细胞部分(CK19+)和未标记的细胞部分(其它)在扩增后类似。这表明与生长于含有血清的培养基中的细胞相比，用无血清培养基替换血清维持了CK19+的部分，没有成纤维细胞的过度生长。
[00069]实施例5。在含有10％胎牛血清、0.01mg/ml胰岛素、0.0055mg/ml转铁蛋白、0.0067μg/ml亚硒酸钠、10ng/mlEGF、4mmol/L谷氨酰胺和抗生素的1∶1比例的EMEM和FamsF12中培养初级胰腺细胞几天。培养2天后(离体4天)，腺泡细胞的淀粉酶的表达仍然很强(图8A，上左图，红色染色)，如免疫细胞化学分析所确定。CK19的表达也很明显(图8B，下左图，绿色染色)。两个图象的重叠(图8C)清楚表明在大部分细胞中共表达淀粉酶和CK19，表明从淀粉酶+腺泡细胞活性转化为淀粉酶+/CK19+混合的腺泡/导管表型(AD细胞)的中间细胞的存在。培养物的每天评价(图9)证明CK19的表达开始于培养的大约第2天，到第5天，培养物已经丧失大多数的免疫可检测淀粉酶的表达，而CK 19的表达占优势。
[00070]实施例6。在PCM/胶原I表面中生长7天后，固定细胞，用CK19抗体染色，用核DAPI复染。通过自动图象分析估计总细胞数(图10A左图，蓝色染色的细胞核)，同时计数CK19+细胞(图10B，右图，绿色染色的细胞质)。在378个总细胞中，342个是CK19免疫阳性的(90％)。使用此处所述的条件培养大约7天后，腺泡细胞具有特定的导管特征，此时称为IP细胞。对于大多数初级人培养物，在约7天后的培养物中多于80％的细胞表达如CK19标志，其与来自多种组织的导管细胞相关。
[00071]实施例7：7天的培养物(IP细胞)的基因表达分析。两个独立的IP细胞培养物进行Clontech 8K Atlas Gene Array分析。通过在包含PCM和胶原I表面的细胞培养体系中培养初级腺泡细胞获得IP细胞。用PBS冲洗单层培养物2次，然后用0.25％的胰蛋白酶使单层培养物从培养瓶脱附。以1,200RPM在吊桶式离心机上离心3分钟沉淀细胞。细胞沉淀重悬并在PBS中洗涤2次，然后如上所述以1,200RPM最后离心3分钟。弃上清，轻轻吸取以从细胞沉淀移去尽可能多的液体，然后将细胞沉淀快速冷冻于干冰/乙醇浴中，并保存在-80℃，直至转移至BD Clontech，在此使用常规技术进行基因表达的分析。
[00072]从每个样品的30μg总RNA，首先使用链霉亲和素-磁性小珠分离方法(其为Atlas Pure Total RNA标记系统的一部分)富集poly+RNA制备标记的P-33cDNA探针。来自每个样品的标记的探针与塑料的人8K基因阵列杂交约16小时，洗涤该阵列，并根据Atlas阵列方案进行成像。使用Atlas图象2.7软件比对阵列图象与阵列格子模板(grid template)，排除假的背景信号或由于强信号溢出造成的假信号。然后使用Atlas图象2.7软件从这些比对的阵列提取转录信号并进一步进行基因表达改变的统计学分析。
[00073]通常，通过杂交合适的寡核苷酸探针分析mRNA转录。在很少的情况下，例如对于CK19和淀粉酶，使用常规的免疫组化方法测定蛋白质表达产物。表4中总结了这些细胞群对选定的组的基因的表达。表4包含在IP细胞中表达的基因的列表和在初级腺泡细胞和初级导管细胞中表达形式的比较。标“+”的基因产物是被表达的，那些标“++”的是强烈表达的。标_的基因产物为再生胰腺中发现的。
表4
 基因   IP细胞   初级导管细胞   初级腺泡细胞
 水通道蛋白1   +   ++(mRNA)/+(蛋白质)   0
 水通道蛋白5   ++   +(mRNA)/-(蛋白质)
 水通道蛋白8   +   -   +
 胰岛素受体底物-2   +   ++_
 蛋白激酶B(AKT)   0   +   +
 钙蛋白酶(mu)   ++   -   ++
 CFTR(囊性纤维化跨膜传导调节蛋白)   0   0   0
 Claudin2   nd   ++   -
 Claudin3   +   +   +
 Claudin4   +   +   +
 Claudin5   nd   -   ++
 碳酸酐酶II   0   0   0
 肌醇1，4，5三磷酸Rc，3型   ++   -   ++
 MUC-1   +   ++   +
 MUC-6   ++   +
 细胞角蛋白7   ++   ++   -
 细胞角蛋白8   ++   +
 细胞角蛋白18   +   +
 细胞角蛋白19   +   ++   -
 αv整联蛋白   0   +
 α3整联蛋白   ++   n/a
 β3整联蛋白   0   +
 β4整联蛋白   +   n/a
 β5整联蛋白   0   +
 纤连蛋白   0   +
 胶原IV   +   +
 玻连蛋白   0   +_
 MMP2   0   痕量
 MMP9   +   痕量
 TIMP1   ++   痕量
 TGF-α   痕量   ++_
 胃泌素   0   ++_
 ICAM-1   0   0
 ICAM-2   0   0
 ICAM-3   0   0
 胃炎相关蛋白(RAP)   ++   +_   痕量
 Reg-1   +   0   痕量
 Pyrimicinergic受体P2Y   +   +
 多配体聚糖   +   +(低)   痕量
 谷胱甘肽S转移酶-π   +   +   -
II.腺上皮细胞转化为胰岛素产生细胞-通过IP培养物的分化制备胰岛素产生细胞(培养阶段II)。
[00074]通过将细胞置于包括促进IP细胞附着的表面(如胶原I)和组合有确定的培养基制剂(无血清但含有下列分化促进因子的组合：活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚单位、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-1)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、催乳素、Sonic Hedgehog、P物质、TGFα、Trolox(α生育酚衍生物)和VEGF)的第二阶段培养可以利用IP培养物产生胰岛素产生细胞。在下列实例中，基础培养基由Hams F12和DMEM的1∶1混合物和抗生素以及0.2％牛血清白蛋白(级分V，热失活的99％纯)组成。在一个实例中(组合1)，基础培养基含有霍乱毒素B、地塞米松、GRP、GLP-1、葡萄糖、IGF1、IGF2、胰岛素、催乳素、SonicHedgehog、Trolox、aFGF和bFGF。在另一个实例中(组合2)，基础培养基包含活化素A、CGRP-α、CNP、葡萄糖、GLP-1、IGF2、胰岛素、LIF、Met-脑啡肽、催乳素、Sonic Hedgehog、aFGF和VEGF。在第三个实例中(组合3)，基础培养基含有活化素A、CGRP-α、霍乱毒素B、地塞米松、葡萄糖、GLP-1、胰岛素、LIF、层粘连蛋白、Met-脑啡肽、PDGFAA/BB、Sonic Hedgehog、P物质、TGFα、αFGF和VEGF。这些培养基添加物的浓度列于表1。
[00075]通过：1)从细胞产生的表面胰蛋白酶消化细胞，以～5×104细胞/cm2的密度重新分布在新鲜附着促进表面，或2)移去培养基，用PBS洗涤2次移去痕量的旧培养基，并用含分化促进因子的新培养基(上述)再饲养，进行AD细胞的培养。在37℃和21％氧下培养细胞4-10天。在第5天，移去一半的培养基并替换为等量的新鲜含分化促进因子的培养基。
分化培养后的IP细胞的表型分析。
[00076]在上述分化条件下培养的IP细胞的表型分析通过光学显微镜进行(参见下面的实施例8)。含有这些培养物的细胞的细胞表型通过上述的使用波形蛋白、胰岛素原、C-肽、MUC-1和CK19的单克隆抗体的免疫细胞化学分析进行评价(参见下面的实施例10)。简言之，用10％的福尔马林室温固定培养物1小时，然后用PBS洗涤并进行免疫细胞化学程序。(参见下面的实施例9)。
分化培养后IP细胞的功能分析。
[00077]聚集的细胞簇释放胰岛素和C-肽的能力通过将培养的细胞进行如下的葡萄糖攻击来评价。用PBS洗涤在分化培养基中已经培养7-10天的细胞3次，然后用1)基础培养基(上述)加5mM葡萄糖，或2)基础培养基加22mM葡萄糖再饲养。18小时后，收集细胞条件培养基(cell-conditioned medium)并进行胰岛素和C-肽释放的ELISA分析(Diagnostic Systems Laboratories(DSL))。使用标准范围测定方法根据制造商的说明进行ELISA。在测定期间将平板置于振荡器上温育，在Tecan分光光度平板阅读仪上读取结果。计算每种培养基条件(5mM葡萄糖培养基和22mM葡萄糖培养基)的每孔胰岛素和C-肽的总ng(参见实施例10)。
[00078]实施例8。在基础培养基+ITS+血清(10％)中培养胰腺腺泡细胞一周，然后胰蛋白酶消化(用0.25％的胰蛋白酶无EDTA 37℃处理10分钟)并转至新鲜的胶原I包被的表面，并置于含有所列的23种DFP的培养基中。过3-5天，细胞容易形成三维荚状(pod-like)结构，通过光学显微镜清晰可见(图11)。培养约4-6天后一些较大的荚从培养表面脱落，并保持存活，如台盼蓝排除所确定。这些荚状结构假设为胰岛素产生细胞的聚集，如下所述进行进一步的分析。
[00079]实施例9。如上实施例所述相同方式产生的荚状结构用10％福尔马林固定并如上所述首先用CK19单克隆抗体，然后用C-肽单克隆抗体进行免疫细胞化学分析。图12A显示了一群细胞(DAPI染色的核是蓝色的)，其中一些是CK19免疫阳性的(绿色染色)。图12B显示了同一群细胞，其中许多是C-肽阳性的，其是当在细胞内合成的胰岛素原分子断裂产生成熟胰岛素时产生的，C-肽染色的细胞是红色的，具有典型的细胞质的颗粒状染色。图12C显示了高倍重叠图象，表明在一小群细胞中CK19和C-肽的共定位。在重叠图象上共染色的细胞呈现桔黄色。
[00080]实施例10。评价在基础培养基(阴性对照)或组合1、2和3分化促进培养基中培养的细胞向培养基释放胰岛素和C-肽的能力。另外，我们评价了是否增加葡萄糖的浓度会导致释放更大量的胰岛素和C-肽，这表明胰岛样功能。首先，将细胞在基础培养基+EGF(10ng/ml)+ITS+10％胎牛血清(PCM)中培养1周。然后或者将进行洗涤并更换培养基(非传代培养)，或者将细胞进行洗涤、胰蛋白酶消化/脱附，重饲养以及更换培养基。一式两份的培养物用基础培养基(无血清)、新鲜PCM和催化促进培养基的三种组合之一(都是无血清的)再饲养。10天后，移去分化培养基，用PBS洗涤培养物3次，然后用含有5mM或22mM(终浓度)葡萄糖的无血清基础培养基再饲养。18小时后，收集条件培养基并用胰岛素或C-肽的抗体(DSL实验室)进行ELISA分析。图13A、13B、13C分别显示了非传代培养的细胞的胰岛素释放和响应葡萄糖攻击的胰岛素和C-肽释放。由于一些培养物含有胰岛素，细胞可以从培养基中摄取胰岛素，所以C-肽的产生是所述细胞正在从合成和加工胰岛素原重新合成胰岛素的重要证明。另外，在多数情况胰岛素和C-肽的产生随着葡萄糖浓度的增加而增加，暗示该培养物内细胞的胰岛样功能。注意到在不含有DPF的基础培养基内几乎没有胰岛素或C-肽产生。
[00081]实施例11。测量了进行经过或不经过酶脱附和传代培养的分化培养的IP细胞的胰岛素的量和DNA的量。精确如上段所述的进行培养。使用标准的Picogreen测定法(Molecular Probes)测量了DNA，而用ELISA测定测量了胰岛素。胰岛素的总ng除以样品中DNA的总μg，因而给出了胰岛素：DNA的比值，以计算胰岛素存在的量与细胞存在的数(由DNA含量反映)的比。结果如图14所示。在每一个分化培养基组合中，胰岛素：DNA的比相比基础培养基都增加，暗示在DPF存在下的每个细胞比不用DPF培养时产生更多的胰岛素。另外，在某些条件下对于葡萄糖攻击(22mM比5mM)胰岛素：DNA的比值略微增加，表明细胞响应葡萄糖释放更大量的胰岛素。
[00082]实施例12。通过以上方法获得的胰岛素释放细胞如上所述进行基因表达分析。表5包含了高度表达的基因的清单，它们在Clontech atlas 8K基因阵列上的位置和这些基因的相对表达(标准化后的)。表5以附件1附于此后。
[00083]以0.5×105细胞/cm2的密度将初级人胰腺细胞接种于胶原I表面PCM中，生长7天。在第1、7和10天如下测量胰岛素：移去生长培养基，在磷酸缓冲盐水中洗涤孔3次。在不含胰岛素含5mM葡萄糖的基础培养基中37℃预温育1小时，移去培养基并换上1)含5mM葡萄糖的基础培养基(不含胰岛素)，或2)含22mM葡萄糖的基础培养基(不含胰岛素)。在37℃18小时后测量细胞条件培养基中的胰岛素。培养7天后，用1)新鲜PCM，2)无血清基础培养基，3)含有所有23种分化因子的无血清基础培养基，4)无血清组合1，或5)无血清组合2替换PCM培养基。结果如图15所示。暴露于分化因子3天后，在分化因子的存在下注意到增加的胰岛素释放。第1天的结果反驳了在原料中存在大量的胰岛素产生细胞，证明从初级培养中的腺泡细胞重新产生胰岛素细胞。在图中可以看出在第10天结束时，在DFP培养基中响应葡萄糖攻击的胰岛素释放比PCM中或基础培养基中高得多，证明了DFP对腺上皮细胞转化为胰岛素产生细胞发挥的刺激作用。
[00084]实施例14。在PCM中在胶原I表面上培养人胰腺腺泡细胞1-7天，因此在第7天产生IP细胞培养物。在第7天，洗涤IP细胞，并用含有表2所列的30种因子的G09分化培养基更换PCM培养基。在每个时间点(第1、7、10和14天)，通过用PBS洗涤培养物3次、然后用含有5mM或22mM葡萄糖的DMEM和HAMs F12的1∶1混合物攻击该培养物来测量胰岛素的释放。暴露于葡萄糖18小时后，收集上清，ELISA测量胰岛素。结果如图15a所示。
III.在被扩增、使其分化为IP细胞并且然后使其进一步分化为胰岛素产生细胞的初级人腺泡细胞的几个时间点的表达研究
[00085]实施例15。将三份独立的初级人胰腺腺泡细胞样品接种并如上所述扩增。从第0天到第8天，细胞以104细胞/cm2接种于PCM中胶原I表面上。在第8天，将培养基由PCM更换为含有表2所列活性因子的培养基。在第8天至第16天之间供给G09两次(更换50％的培养基)。整个培养过程细胞保持在表面上。在初始接种后第3天(活跃转分化的腺泡细胞)、接种后第8天(IP细胞)和接种后第16天(推定的胰岛素产生细胞)收获培养物并如实施例7所示进行基因表达分析。用Clonetech的12K微阵列获得mRNA表达数据。
[00086]简言之，从培养瓶中移去生长培养基，在trizol LS(Invitogen)离液剂/酚试剂中通过吸取裂解液覆盖细胞层而裂解细胞约2分钟。在Oak Ridge离心管中每9ml裂解液中加入3ml无RNA酶的水。然后加入2.4ml氯仿，剧烈振荡溶液1分钟。在4℃离心分离水相和有机相，将上层含有RNA的水相移至洁净的PET管中。用异丙醇沉淀RNA，用70％乙醇洗涤，重新溶解于200μl的无RNA酶的水中。立即向RNA中加入离液剂裂解试剂，使用具有DNA酶消化步骤的Qiagen旋转柱方法(spin column method)进一步纯化RNA。纯化的RNA最后稀释在80μl的无RNA酶的水中并保存于-80℃。
[00087]从每个样品的30μg总RNA，首先使用链霉亲和素-磁性小珠分离方法(其为Atlas Pure Total RNA标记系统的一部分)富集poly+RNA制备标记的P-33cDNA探针。来自每个样品的标记的探针与塑料的人12K基因阵列杂交约16小时，洗涤该阵列，并根据Atlas阵列方案进行成像。使用Atlas图象2.7软件比对阵列图象与阵列格子模板(grid template)，排除假的背景信号或由于强信号溢出造成的假信号。然后使用Atlas图象2.7软件从这些比对的阵列提取转录信号并进一步进行基因表达改变的统计学分析。
[00088]如下分析原始的表达数据：(1)我们过滤掉在三种条件/时间点任一个都不表达的基因；(2)我们将所有的微阵列互相标准化以除去阵列-阵列的差异和样品加工、杂交等差异的影响；(3)我们鉴定了在条件/时间点间表现显著统计学差异的基因；和(4)我们基于基因暂时性特性将它们分组(其与研究的设计和表型的改变一定程度的一致)。
[00089]表6显示了上述分析所确定的基因的表达数据。该表以附件2附于这里。这些确定的基因在第3天和第8天都高水平表达，或者它们的表达在第3天至第8天基本是增加的。该表还显示了在第16天这些基因的表达水平，以及对于所有三种条件/时间点的平均表达。该表还显示了在不同时间的表达比：“I与A”是推定的胰岛素产生细胞(第16天)与腺泡细胞(第8天)的表达比；“Int与A”是IP细胞(第8天)与腺泡细胞(第3天)的比。
[00090]通过将其分成17“种类”的一种，进一步分析表6中所示的数据，其特征总结于表中。这17类的性质的图示见图16。
[00091]表6第8天的时间点的数据也根据在这些细胞中在第8天表达的基因是否属于正常表达于(1)肝和胰腺；(2)胰腺相关基因；(3)肝相关基因；或(4)祖细胞相关基因的基因类别进行分组。结果如表7所示。
表7BDT中间细胞
  在肝和胰腺中表达的基因   样品1   样品2   样品3   肝表达型式   胰腺表达型式
  CK18   +   +   +   肝谱系   腺泡细胞
  CK8   +   +   +   肝谱系   腺泡细胞
  CK19   +   +   +   胆管   导管细胞
  CK7   +   +   +   胆管   导管细胞
  HNF1   +   +   +   肝tc因子   在β细胞中
  α-1抗胰蛋白酶   ++   ++   ++   在分化的肝细胞中产生   是
  Notch-1   -   -   痕量   参与细胞分化为肝谱系   发育胰腺上皮
  甲种胎儿蛋白   -   -   -   发育肝细胞和肝祖细胞   发育胰腺导管
  Notch-3   痕量   痕量   痕量   参与细胞分化为肝谱系   胰腺间充质和内皮
  Notch-4   痕量   痕量   痕量-   参与细胞分化为肝谱系   胰腺间充质和内皮
  Jagged-2   +   +   +   参与细胞分化为肝谱系   是
  π-谷氨酰胺s转移酶(π-GST)   +   +   ++   发育肝   导管细胞和中心腺泡细胞
  γ-谷酰胺基转移酶   -   -   -   发育胆管   腺泡细胞
  胰腺相关基因   样品1   样品2   样品3   肝表达型式   胰腺表达型式
  碳酸酐酶   -   -   痕量   不   导管细胞
  CF跨膜传导调节蛋白   -   -   痕量   不   导管细胞
  弹性蛋白酶   -   -   -   不   腺泡细胞
  淀粉酶   -   -   -   不   腺泡细胞
  胰岛素   +   痕量   痕量   不   胰岛
  抑生长素   痕量   痕量   痕量   不   胰岛
  胰腺多肽   +   +   痕量   不   胰岛
  胰高血糖素   -   -   -   不   胰岛
  肝相关基因   样品1   样品2   样品3   肝表达型式   胰腺表达型式
  唾液酸转移酶-6   -   -   -   分化的肝细胞中产生   不
  肝特异bHLH转录因子   +   +   +   肝特异Tc因子   不
  Thy-1   +   +   +   肝卵形细胞标志   不
  葡萄糖-6-磷酸酶   -   -   痕量   肝谱系，祖细胞和成人   不
  谷氨酰胺合成酶   -   -   痕量   肝细胞   不
  氨甲酰磷酸合成酶-1   -   -   -   肝细胞   不
  二肽基肽酶IV   -   -   -   肝细胞   不
  C/EBP-α   ++   ++   +   肝特异Tc因子   *在胰腺肝样变(铜缺乏食物)过程中启动和上调
  C/EBP-β   ++   ++   ++   肝特异Tc因子   *在胰腺肝样变(铜缺乏食物)过程中启动和上调
  祖细胞相关基因   样品1   样品2   样品3   组织
  Musashi-1   -   -   -   肠
  Nestin   -   -   -   胰腺/神经元
  CD34   -   -   -   造血细胞
  Thy-1   -   -   -   肝祖细胞
  BMP-2   -   -   -   神经元
  BMPRclA   -   -   痕量   间充质
  c-kit   -   -   -   肝/胰腺/神经元
  噬铬粒蛋白A   痕量   痕量   痕量   神经内分泌/肝/肠
  PDX-1   -   -   +   胰腺
[00092]可以看出，在第8天，IP细胞不再表达与胰腺腺泡细胞一致的基因，它们也不表达特异于胰腺导管细胞的补充基因。IP细胞表达低水平的与胰腺胰岛相关的一些标志，包括胰岛素，抑生长素和胰腺多肽，暗示在该群体中至少一些细胞能表达胰腺胰岛的内分泌基因。
[00093]令人惊奇的，IP细胞也表达几种肝特异的转录因子(例如C/EBPα，C/EBPβ)和成熟和发育肝的其它标志，包括低水平的Thy-1，一种与肝“卵形”干细胞相关的标志。这暗示分化细胞不单单地从胰腺腺泡移向胰腺导管，而发育成既具有肝特征也具有胰腺特征的细胞，而不适合这些细胞类型之一的任一单一的基因表达形式。在该实例中产生的细胞类似喂食铜缺乏的食物的啮齿类的胰腺出现的细胞。(参见例如Rao等人，1988)。这些动物的胰腺经历胰腺炎的急性期，然后是“肝样变”(其意味着细胞开始表达肝基因而不是胰腺基因)。也已经报导在人胎胰腺(Tsanadis等人，1995)中有肝样细胞。由本发明方法产生的分离的细胞(例如通过通过本发明方法增殖初级腺泡细胞和其它类型的内胚层细胞或组细胞)区别于可能具有某些IP细胞特征的天然产生的细胞，如卵形细胞或分离自铜缺乏食物的啮齿类的胰腺的细胞。
[00094]具有这些IP细胞特征的细胞可能对治疗糖尿病的治疗方法有用。另外，尽管该实施例中的细胞分离自胰腺，但是其它上皮组织或可能甚至任何内胚层来源的组织都可能提供能分化为具有类似表型的细胞的另外的来源。合适的组织类型包括例如肝或肠。这些IP细胞表达与胰腺、肝、肠和神经组织相关的基因。例如，它们表达粘蛋白、CK19和CK7，它们是与胰腺、肝和肠导管细胞相关的共同的标志。因此，在IP细胞中看到的基因表达模式可能作为来自每一这些组织的细胞用于产生胰岛素产生细胞的预示测量。另外，IP细胞可能在合适的条件下不只产生胰腺胰岛细胞，还产生肝细胞和任何内胚层来源的组织。
[00095]以上所引用的下列参考文献与本发明有关：
   WO 02/29010A2(Kerr-Conte)；
   Bonner-Weir，S.et al.，Proc.Natl.Acad.Sci.USA 97：7999-8004(2000)，
   Bouwens，L.，Microsc.Res.Tech.43：332-6(1998)，
   Bowens，L.et al.Diabetologia 41：629-33(1998)；
   Gmyr，V.et al.，Diabetes 49：1671-80(2000)；
   Gmyr，V.et al.Cell Transplant 10：109-21(2001)，
   Gmyr，V.et al.Diabetes 49：1671-80(2000)，
   Hall，P.A.et al.，J.Pathol.166：97-103(1992)；
   Kerr-Conte，J.et al.，Diabetes 45：1108-14(1996)；
   Kerr-Conte，J.et al.，Transplant Proc 27：3268(1985)；
   Pattou F.et al.，Bull.Acad.Natl.Med.184：1887-99(2000)；
   Rao，MS et al Biochem Biophys Res Comm.156：131-6(1988)；
   Rooman，Ilse et al.，Diabetes 51：686-90(2002)；
   Rooman，I，et al.Diabetologia 43：907-14(2000)；
   Rooman，L.et al.，Gastroenterology 121：940-9(2001)；
   Trivedi，N.et al.Endocrinology 142：2115-22(2001)；
   Tsanadis，G.et al.Histol.Histopathol.10：1-10(1995)；
   Wang，R.N.et al.，Diabetologia 38：1405-11(1995)；
   USP 6,011,647(Ammon Peck).
[00096]本说明书中阐明和讨论的实施方案只是意欲教导本领域技术人员本发明者所知的完成和使用本发明的最佳方式，不应被视为对本发明的限制。本发明举例说明的实施方案可能被修饰或变化，加入或删除元素而不背离本发明，这是本领域技术人员根据上述教导应该理解的。因此应该理解，除了具体描述的外，在本权利要求书和其等价物的范围内，本发明可以被实施。
[00097]以上所引用的所有申请、专利和出版物以及附图中的全部内容在此全文引入以供参考。
附件1：表5
  基因   在Atlas8K阵列上的位置   相对表达，样品1   相对表达，样品2
  水通道蛋白5   7547   4539   4550
  肌动蛋白，β   3952   3598   3442
  肌动蛋白，β   8176   3047   3747
  生长激素促分泌素受体   6846   2092   1710
  抑制蛋白1   448   1580   1246
  特殊AT富集序列结合蛋白1(结合核基质/支架-结合DNA)   3035   1437   886
  心特异性同源框   2050   1395   2850
  CCAAT/增强子结合蛋白(C/EBP)，β   1588   1374   1671
  RAS脒基释放蛋白2(钙和DAG调节的)   8262   1263   1616
  软骨配对类同源异型蛋白质1   6677   1166   1241
  成对样同源域转录因子1   6805   1113   756
  转录因子21   7621   1063   801
  CD3E抗原，ε多肽(TIT3复合体)   8054   994   1113
  CD151抗原   5613   935   808
  ATPase，Ca++转运，血浆，膜2   7940   919   876
  Ficolin(含有胶原/纤维蛋白原结构域)3(Hakata抗原)   824   901   829
  肌醇多磷酸磷酸酶样-1   5989   832   425
  蛋白质酪氨酸磷酸酶，受体型，S   8367   806   810
  整合蛋白，α3(抗原CD49C，VLA-3受体的α3亚单位)   1743   758   647
  突触融合蛋白1A(脑)   6851   743   658
  parathymosin   7135   725   852
  胸腺素，β10   7436   709   1617
  Midkine(轴突生长促进因子2)   2470   682   802
  芳基硫酸酯酶A   3147   678   3034
  钙结合蛋白2(29KD，钙视网膜蛋白)   7000   676   786
  丝氨酸(或半光氨酸)蛋白酶抑制剂，分化体A(α-1抗蛋白酶，抗胰蛋白酶)，成员1   5214   668   678
  视黄醛G蛋白偶联受体   7972   653   696
  肌球蛋白调节轻链2，平滑肌同种型   2499   638   561
  丁酸反应因子1(EGF-反应因子1)   7325   630   646
  1型跨膜受体(抽搐相关蛋白)   7583   589   394
  1型跨膜受体(抽搐相关蛋白)   7583   589   394
  胶原蛋白原C-内肽酶增强子   3593   576   713
  促分裂原活化蛋白激酶激酶2   7069   558   571
  蛋白酶，丝氨酸，1(胰蛋白酶1)   6323   558   656
  胰腺炎相关蛋白   4576   536   2177
  血管紧张素受体1B   4093   516   491
  Stratifin   6489   503   581
  角蛋白17   7903   500   364
  抑生长素受体3   6872   432   433
  肌球蛋白结合蛋白H   4692   428   96
  Ephrin-A5   4202   411   381
  RAP1，GTP酶活化蛋白1   1965   407   263
  胰凝乳蛋白酶原B1   6604   405   830
  具有跨膜结构域的锚蛋白样1   3577   395   431
  Misshapen/NIK-相关激酶   2439   391   341
  骨形态发生蛋白6   4492   381   308
  拼接因子富含脯氨酸/谷氨酰胺(多嘧啶段结合蛋白相关)   713   375   662
  Claudin12   2720   370   378
  基质金属蛋白酶23A   7491   368   138
  Neurogranin(蛋白激酶C底物，RC3)   4465   366   335
  多巴胺受体D2   1649   362   234
  向心素1   5283   359   507
  CCAAT/增强子结合蛋白(C/EBP)，α   7237   359   645
  成对盒基因9   5206   335   201
  蛋白酪氨酸磷酸酶，受体型，N   8235   331   250
  角蛋白8   7215   327   449
  Claudin 7   280   325   173
  trophinin相关蛋白(tastin)   462   323   360
  神经元细丝蛋白(neuronal threadprotein)   8356   322   366
  含有碱性螺旋-环-螺旋结构域，B类，2   6734   318   215
  膜联蛋白A2   4467   290   226
  组织蛋白酶D(溶酶体天冬酰胺基蛋白酶)   7370   289   600
  Bicaudal D(国蝇属)同系物1   6822   284   217
  凝集素，半乳糖苷结合，可溶的，1   7331   280   310
  (galectinl)
  角蛋白7   7171   278   481
  甘油醛-3-磷酸脱氢酶   3953   278   307
  水通道蛋白6，肾特异   7591   277   258
  TNF受体相关因子1   6037   269   270
  RhoGDP解离抑制剂(GDI)α   5565   267   321
  钙通道，电压依赖的，γ亚基4   3142   260   207
  谷氨酸受体，离子化，kainatel   4776   244   296
  CCR4-NOT转录复合物，亚基4   983   244   428
  细丝蛋白A，α(肌动蛋白结合蛋白-280)   3457   241   233
  花生(国蝇属)样1   711   233   310
  不发育增强子(国蝇属)同系物   5921   231   409
  内皮素转变酶1   7835   229   197
  Protocadherin17   2483   223   208
  水通道蛋白8   7679   217   145
  突触蛋白I   4871   216   164
  微管蛋白，α，脑特异的   2827   212   345
  CD44抗原(归巢功能盒印第安人血型系统)   7848   207   141
  脑海绵状畸形1   2731   205   116
  胰岛素样3(Leydig细胞)   666   202   365
  腺苷酸环化酶活化多肽1(垂体)   4489   200   74
  少毛(小鼠)同系物   5185   196   36
  胰岛素   4427   190   44
  颗粒体蛋白   928   184   201
  颗粒体蛋白   928   184   201
  早生长反应1   2111   178   136
  细胞周期蛋白依赖的激酶抑制剂1A(p21，Cip1)   7852   175   108
  干细胞生长因子；淋巴细胞分泌的C-型凝集素   1606   174   152
  CD4抗原(p55)   5608   172   143
  PCTAIRE蛋白激酶1   6334   161   78
  RhoGTP酶活化蛋白6   1035   160   220
  G蛋白偶联的受体37(内皮素受体B型样)   6318   158   35
  多配体聚糖4(双栖蛋白聚糖，ryudocan)   3154   157   147
  PCTAIRE蛋白激酶3   8050   155   159
  空气门(empty spiracles)(国蝇属)同系物2   2084   150   207
  转谷氨酰胺酶(K多肽上皮型1，蛋白-谷氨酰胺-γ-谷氨酰基转移酶)   6674   150   101
  钾电压-门控通道，亚家族G，成员2   1335   147   62
  乙醛脱氢酶4(谷氨酸-γ-半醛脱氢酶；吡咯啉-5-羧酸酯脱氢酶)   5985   147   207
  E1A结合蛋白p300   1433   144   197
  LIM同源异型盒转录因子1，β   8211   143   89
  真核翻译延伸因子2   4536   134   150
  促分裂原活化蛋白激酶激酶激酶10   5462   129   92
  PPAR(γ)angiopoietin相关蛋白   3074   129   56
  同源异型盒A5   7037   128   87
  CD63抗原(黑素瘤1抗原)   7769   124   91
  核受体共活化子3   4181   119   84
  CD68抗原   443   118   256
  跨膜4超家族成员7   1571   117   29
  胰腺多肽   2735   116   136
  内皮素b型受体样蛋白2   6656   114   74
  neurogenin 1   5772   113   91
  胰岛素受体物质2   6016   110   130
  谷氨酸受体，离子型，N-甲基D-天冬氨酸相关蛋白1(谷氨酸结合)   4702   109   58
  neurotrophin 5(neurotrophin 4/5)   8259   108   89
  Pyrimidinergic受体P2Y，G蛋白偶联，6   3857   105   65
  空气门(empty spiracles)(国蝇属)同系物1   2040   103   87
  Chromobox同系物2(国蝇属Pc种)   2832   101   139
  心核神经脊突衍生物表达1   2146   92   129
  转谷氨酰胺酶2(C多肽，蛋白-谷氨酰胺-γ-谷氨酰基转移酶)   7731   92   74
  烯醇化酶1(α)   1389   92   205
  甲状腺转录因子1   4519   89   60
  角蛋白19   5923   88   223
  缺失的裂手/裂脚1区(deleted insplit-hand/split-foot 1 region)   3641   87   104
  谷胱甘肽过氧化物酶4(磷脂氢过氧化物   1874   84   72
  酶)
  无芒(aristaless)(国蝇属)同源异型盒   1783   81   103
  GATA-结合蛋白4   659   80   110
  转录因子1，肝，LF-B1，肝核因子(HNF1)，白蛋白近似因子   712   80   136
  热休克转录因子   6708   79   57
  肝特异的bHLH-Zip转录因子   765   77   188
  肝特异的bHLH-Zip转录因子   765   77   188
  真核翻译起始因子3，亚基4(δ，44KD)   6280   76   94
  真核翻译起始因子3，亚基4(δ，44KD)   6280   76   94
  γ-氨基丁酸(GABA)A受体，α6   3720   70   178
  视黄酸受体γ   5191   70   109
  同源异型盒D9   1776   69   34
  MAD1(有丝分裂停止缺陷，酵母，同系物)样-1   1946   63   38
  同源异型盒A4   7177   57   103
  Thy-1细胞表面抗原   559   57   87
  踝蛋白   603   53   84
  骨形态发生蛋白受体，II型(丝氨酸/苏氨酸激酶)   332   53   45
  肝细胞盒因子3，α   72   52   60
  Ryanodine受体2(心)   5244   47   40
  转录6的信号转导子盒活化子，白介素-4诱导的   3661   40   35
表6
  SwissProt   斑点   基因名称   第3天   第8天   第16天   全平均值   I与A比值   Int与A比值   分类ID   分类名称
  P04270O95996Q14697P14209P30530O43770O43852O75718Q9Y3C0P78369P08572P11802Q16555P33316P07992O75636Q9UBA6Q9Y5P5O75293P50152Q9NX09P05204Q9P0P2Q9NWF8Q9NWV4Q9P0S8Q9BWS9Q9BSK0Q9Y6M1Q9NQX7   E19ab2N17ab2G02ef8G23ab7G14ef5I23ab3P08ab3O24cd6G14ef2G09cd6P08ef6B05ef5O07ab4H23ab5K20ef6B14cd3B19ef4P08ef7E02ef7C05ab6C05gh3J22ab7C17ef3L15gh2B17gh2A21ef3P04gh5K21gh8P09cd6H02gh7   肌动蛋白；α；心肌腺瘤性结肠息肉病样α葡萄糖苷酶IIα亚基单克隆抗体12E7；F21和O13鉴定的抗原AXL受体酪氨酸激酶B-细胞CLL/淋巴瘤7Ccalumenin软骨相关蛋白质CGI-116蛋白质claudin 10胶原；IV型；α2细胞周期蛋白依赖性蛋白激酶4二氢嘧啶酶样2dUTP焦磷酸酶切除修复交叉互补啮齿类修复缺陷；互补组1(包括重叠反义序列)ficolin(包含胶原/纤维蛋白原结构域)3(Hakata抗原)G8蛋白质GDP-甘露糖焦磷酸化酶A生长停滞和DNA损伤可诱导；β鸟嘌呤核苷酸结合蛋白11HIF-1反应性RTP801高迁移率组(非组蛋白染色体)蛋白17酵母MOG1同系物假定蛋白质FLJ10055假定蛋白质FLJ20580假定蛋白质HSPC195假定蛋白质MGC3234假定蛋白质MGC4415IGF-II mRNA-结合蛋白质2膜内在蛋白质3   1198.1742708.542306.0691389.822314.4639700.573801.582430.4432181.02931176.0871130.23914.1579114.6165177.2032362.0311081.127370.6842171.1216194.3626204.743348.85742067.865325.8407172.167221.4432153.824196.9154156.4692135.2566478.2728   760518035050728810501290256301742135097816423841510105781982031502531120378241280165161117153481   5955.0777594.139775.33581238.43634.56581504.524720.8071090.59416.72462598.5954684.4252342.994921.1473541.5382907.79334327.6061489.206414.0862386.6833497.30971032.9296059.895682.7568374.3483.5381330.9111427.2066684.3425408.51011102.244   2637.6765161.464477.0123711.8924412.21151085.9312269.921592.2327299.72371505.4712389.4881411.839399.8267318.7836561.63882139.448812.6378261.0679261.3841283.8702545.06223082.818462.1583262.6222328.2481216.4274261.7132319.1224232.2937687.2575   2.31E+001.49E+001.34E+001.67E+001.01E+001.10E+002.56E+001.34E+001.20E+001.14E+002.05E+001.36E+003.01E+001.61E+001.33E+002.00E+002.01E+001.27E+009.92E-011.28E+001.57E+001.55E+001.07E+001.12E+001.13E+001.11E+001.12E+002.13E+001.59E+001.20E+00   -6.57E-019.36E-011.92E-013.80E-01-1.29E-015.87E-016.84E-01-7.52E-017.36E-01-6.65E-012.60E-019.79E-025.14E-014.23E-011.97E-01-9.87E-026.41E-012.10E-016.35E-02-4.53E-01-4.61E-01-8.84E-012.14E-014.88E-013.37E-019.72E-02-2.90E-01-4.25E-011.79E-018.97E-03   777777777777777777777777777777   A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升
  P08648O00410P07195P09382O75427Q16553O75900Q9UNF1P13995O00265P27361P24844Q9NVD4Q9Y617O95356Q9Y5X6Q15113O15460O43556P50454Q92853Q16658Q9Y4Y8   E23ef7J24ab6N16ab6N22ab6P20ab6A15ab7O05cd4H16ef7J16cd6G19cd8B13ef5E18cd6J10gh2N22ef8A11gh7G04cd6G20ab8D20cd4I19gh1M17ab6A23cd8P20cd1E18cd7   整联蛋白；α5(纤连蛋白受体；α多肽)karyopherin(importin)β3乳酸脱氢酶B凝集素；结合半乳糖苷；可溶；1(半乳凝素1)富含亮氨酸重复单位的蛋白质；神经元1淋巴细胞抗原6复合物；基因座E基质金属蛋白酶23A黑素瘤抗原；家族D；2亚甲基四氢叶酸脱氢酶(NAD+依赖性)；次甲基四氢叶酸环水解酶微管相关蛋白；RP/EB家族；成员3促分裂原活化蛋白激酶3肌球蛋白；轻链多肽9；调节性N-乙酰神经氨酸磷酸合酶；唾液酸合酶磷酸丝氨酸氨基转移酶脑垂体肿瘤转化3血浆谷氨酸羧肽酶前胶原C-内肽酶增强子前胶原-脯氨酸；2-酮戊二酸4-双加氧酶(脯氨酸4-羟化酶)；α多肽II肌糖蛋白；ε丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade H(热休克蛋白47)；成员2类似于牛痘病毒HindIII K4L ORFsinged-like(fascin同系物；海胆)(果蝇)Sm蛋白质F   183.4629326.68741003.97119170.52174.9605425.8933381.2184193.8125321.4878189.7616358.08725480.451153.4762169.9503237.2126169.6268497.3967262.1395172.7191339.1762444.062262.7872257.2026   1241961200354002314942972192262343827380167250192142402433215612553479278   478.7266629.76565593.07978086.75543.3883938.4504851.7221659.9701759.6021377.5576720.311922518.95390.66421238.8512276.181366.62022628.947756.4003349.3044091.161997.45511472.155548.9705   262.0713384.24022599.0544205.77316.5457619.3701510.1038357.6132435.6746267.156486.84911793.09237.1908553.0005901.8229226.01681176.046483.9569245.52631680.942664.6951738.014361.3772   1.38E+009.47E-012.48E+002.03E+001.63E+001.14E+001.16E+001.77E+001.24E+009.93E-011.01E+002.04E+001.35E+002.87E+003.26E+001.11E+002.40E+001.53E+001.02E+003.59E+001.17E+002.49E+001.09E+00   -5.65E-01-7.35E-012.57E-018.83E-014.03E-012.13E-01-3.58E-011.77E-01-5.09E-013.03E-019.38E-024.29E-011.26E-015.58E-01-3.05E-01-2.58E-01-3.08E-017.25E-013.13E-018.53E-013.15E-018.66E-011.12E-01   77777777777777777777777   A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升
  Q9BVH9Q9HBB0P01033Q15582Q01995Q13641P06468P51784P03996P08123P24821Q9NVA2P40261Q15063P09486P35625Q9H2L5P15121P08582P20292O15342Q9BXJ0Q9NRJ3P05305P09341   D18gh7L08gh8P09ef7L20ef6M07cd2B05ab2G08cd2M21cd4E17ab2P02ef6A05ef7F13gh3M09cd1C01ef7A09ef7K20ef5G06gh8C18ab2B14ef5E06ab2A13ab3H18gh6P09gh4F17ab5A04ab6   硫氧还蛋白相关蛋白质Thy-1共转录金属蛋白1组织抑制剂(红系增能活性；胶原酶抑制剂)转化生长因子；β-诱导；68kDtransgelin滋养层糖蛋白原肌球蛋白2(β)泛素特异性蛋白酶11肌动蛋白；α2；平滑肌；主动脉胶原；I型；α2hexabrachion(腱生蛋白C；肌链抗原)假定蛋白质FLJ10849烟酰胺N-甲基转移酶成骨细胞特异性因子(成束蛋白I样)分泌蛋白质；酸性；富含半胱氨酸(骨粘连蛋白)金属蛋白酶3组织抑制剂(Sorsby眼底营养不良；假性炎症)AD037蛋白质醛-酮还原酶家族1；成员B1(醛糖还原酶)单克隆抗体133.2和96.5鉴定的抗原p97(黑素瘤相关)花生四烯酸5-脂肪氧合酶活化蛋白质ATP酶；H+转运；溶酶体9kD V0亚基eC1q和肿瘤坏死因子相关蛋白质5CC趋化因子CCL28内皮素1GRO1癌基因(黑素瘤生长刺激活性；α)   522.0262327.35021236.4571221.0833307.821479.6488339.2292158.0478412.1187186.5666355.495374.14961060.579276.634404.2839216.254361.22972342.744299.1375100.00166063.171180.2978250.0021866.4561933.2938   481374150020603880426589194194057691886123107952760619681538059568716500350183018104770   1903.9641110.52713029.418540.8618534.271399.78613203.05491.124641801.3414565.362371.9833471.7895683.5338328.22263837.210078.17158.81212337.05280.80392203.29116160.831154.1441763.2866403.4311006.711   968.9954603.81015256.8613939.098573.074768.61584710.469280.981914717.635109.2511215.1651568.8483016.9933133.30122333.483637.823400.46023354.494324.9781330.03459572.914228.0109948.02741026.9922236.622   1.87E+001.76E+003.40E+002.81E+002.49E+001.55E+005.28E+001.64E+006.66E+006.29E+002.74E+003.21E+002.42E+004.91E+007.30E+005.54E+00-1.19E+00-3.51E-03-1.89E+001.02E+002.31E-02-2.26E-011.61E+00-1.10E+001.09E-01   -1.18E-011.90E-012.83E-017.51E-012.29E-01-1.70E-017.96E-012.94E-012.23E+001.63E+001.37E+001.20E+001.12E+001.52E+002.77E+001.52E+009.15E-011.20E+009.92E-012.78E+001.44E+009.55E-012.87E+001.06E+002.35E+00   77777777999999991919191919191g1g1g   A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int相等；胰岛升A/Int/I增加A/Int/I增加A/Int/I增加A/Int/I增加A/Int/I增加A/Int/I增加A/Int/I增加A/Int/I增加Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)
  Q92730Q9H5K0P18564P14316P40305P05161P42701P09237P16860P21359P02775Q9UDQ9O75635P02735O60635P50591Q03169Q9C075P02248O95497Q14202P15514Q9BZL9P30991P29400Q9UK22   O14ef4L10gh5E21ef6B16ef6O20ab7B21cd5A06ef7J15ef1O13ab8L16ab7B07ef7J22gh4P14cd3A11cd3F10cd5C09cd4I10ef7N11ef8A01cd3A15cd5B15cd5M02ef7I21gh8D14ef5H13ab3H22cd7  GTP结合蛋白质假定蛋白质FLJ23360整联蛋白；β6干扰素调节因子2干扰素；α可诱导蛋白质27干扰素刺激蛋白质；15kDa白细胞介素12受体；β1基质金属蛋白酶7(基质溶解因子；子宫)钠尿肽前体B神经纤维瘤蛋白1(神经纤维瘤；von Recklinghausen病；Watson病)前血小板碱性蛋白质(包括血小板碱性蛋白质；β血小板球蛋白；结缔组织活性肽III；嗜中性粒白细胞活性肽2)SBBI26蛋白质丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade B(卵清蛋白)；成员7血清淀粉状蛋白A1tetraspan 1肿瘤坏死因子(配基)超家族；成员10肿瘤坏死因子；α诱导蛋白质2I型中间纤维细胞角蛋白泛素Cvanin 1锌指蛋白261双调蛋白(神经鞘瘤来源的生长因子)B进展性淋巴瘤基因趋化因子(C-X-C基序)；受体4(融合素)胶原；IV型；α5(奥尔波特综合征)仅有F-盒的蛋白质2   653.8575151.2029540.0362252.3603117.3152302.37961227.3479598.5454340.214132.48333.98656121.5886232.6336496.9578321.8888536.7773366.7502848.9829155.6735309.1556199.6246103.1419126.395164.3711553.5094387.59822   276029611804727669832210087300129002921400108038901740084315501260420089218401040405211260374217   542.7528130.3196233.0055255.7047218.2471326.63461333.52119849.691260.906155.0822265.2119238.8624326.2581957.6141177.6479476.2305326.6536401.485462.04595510.7208247.916165.6606784.56927120.2328141.1609120.3781   1318.381192.6442650.9277326.8164367.2688537.40358218.99438905.326171.6193.3208567.1992479.59081483.1696295.724447.5729854.3061650.5831818.182369.9913887.0948496.3668191.2981140.8098148.3131189.6904141.6466   -2.69E-01-2.14E-01-1.21E+001.90E-028.96E-011.11E-011.20E-011.05E+00-1.78E+002.27E-012.96E+009.74E-014.88E-019.46E-01-8.58E-01-1.73E-01-1.67E-01-1.08E+00-1.33E+007.24E-013.13E-01-6.52E-01-5.80E-019.01E-011.40E+004.59E-01   2.08E+009.71E-011.13E+009.04E-012.71E+001.70E+004.17E+003.18E+001.57E+001.14E+005.37E+003.15E+004.06E+005.13E+001.39E+001.53E+001.78E+002.31E+002.52E+002.57E+002.38E+001.97E+007.42E-012.02E+002.81E+001.31E+00   1919191919191919191919191919191919191919191818181818   Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)Int＞(A；I)A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开
  Q16769P02261P20769P52945Q14496P01583P01584Q9GZM1P25105P58294P23471O88386P10826O95786P02778P80162P43005P01375Q16890Q9H949Q9H4G4Q14040P12110P02751P14652P08476   O15cd8M06gh6D03ef1I12ab6F21cd6F15ef7F17ef7I209h7G15ef5O14gh8A06ef6D10ef3I08gh6I24ef3O10ef7F14cd1N23ef5O09ef6G04cd2K11gh5O06gh5B15ef1B17ef1K15ef1N23ab6D15ef7   谷氨酰肽环转移酶(谷氨酰环化酶)H2A组蛋白家族；成员I免疫球蛋白重链恒定区μ胰岛素启动子因子1；同源结构域转录因子干扰素诱导蛋白质44白细胞介素1；α白细胞介素1；βNDRG家族成员4血小板活化因子受体激动素原1前体蛋白酪氨酸磷酸酶；受体型；Z多肽1RAB10；成员RAS癌基因家族视黄酸受体；βRNA解旋酶可诱导小细胞因子亚家族B(Cys-X-Cys)；成员10可诱导小细胞因子亚家族B(Cys-X-Cys)；成员6(粒细胞趋化蛋白质2)溶质载体家族1(神经元/上皮细胞高亲合力谷氨酸转运蛋白；系统Xaq)；成员1肿瘤坏死因子(TNF超家族；成员2)肿瘤蛋白质D52样1WW45蛋白质17kD胎脑蛋白质胶原；VI型；α1胶原；VI型；α2纤连蛋白1同源异形盒B2抑制素；βA(活化素A；活化素ABα多肽)   89.9025265.46028101.24574.6050499.27101103.386116.7675102.132897.4312179.9828685.55935123.200367.98871112.936665.0339554.0082199.30514138.6153103.5477111.881288.6174638.2720388.002824.44136262.7162964.38161   195263176351286375415348356241346399241241418311189386191218223209164152291318   113.0683126.664102.568786.4255898.2805766.6314119.0156101.56980.47935137.516793.6584568.13944120.946989.3239686.09019129.2639110.811975.1343698.0186279.54574532.29794724.4133835.6374171.6033571.974854.6532   132.7502151.868126.7136170.7555161.3017181.5566216.8707183.8736177.9689152.9437175.0253196.7342143.3844147.8829189.6022164.6594133.1898200.0804130.885136.5769281.21481657.1941362.4871442.8121308.575412.2794   3.31E-019.52E-011.87E-022.12E-01-1.45E-02-6.34E-012.75E-02-7.99E-03-2.76E-017.82E-011.30E-01-8.54E-018.31E-01-3.38E-014.05E-011.26E+001.58E-01-8.84E-01-7.92E-02-4.92E-012.59E+006.95E+005.45E+009.88E+005.83E+003.73E+00   1.12E+002.01E+008.00E-012.24E+001.53E+001.86E+001.83E+001.77E+001.87E+001.59E+002.02E+001.69E+001.83E+001.10E+002.68E+002.52E+009.32E-011.48E+008.84E-019.64E-011.33E+002.45E+008.97E-015.10E+002.21E+002.30E+00   1818181818181818181818181818181818181818888888  A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开A/I关；Int开腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加
  P17936Q9Y4K0P03956P39900P55001Q9NYR0O43623P09936Q02952Q99541P54284Q13269Q9NPF2Q9H7A5Q9H9Q2P42771Q14650Q96IK6P12034Q93079Q9P016Q9HBI5Q9BY45P08397Q9BUV0Q9H9A2Q9NUV6Q9NXF7Q9H6V0Q9BUW5   D07ab6P18ab6N05ef7N15ef7G09ab7O07gh7D06ef4I13cd4J11ab2I19ab2N17ab3G14ab5M02ef4F12gh7L23gh5D17ef5J20ef4F14gh6D05ef7M20gh6A10ef8M09gh4O24gh8G18ab6M06gh4N22gh6P09gh3C20gh2M05gh5K21gh6  胰岛素样生长因子结合蛋白质3赖氨酰氧化酶样2基质金属蛋白酶1(间质胶原酶)基质金属蛋白酶12(巨噬细胞弹性蛋白酶)微原纤维相关蛋白质2SH3结构域激酶结合蛋白质1蜗牛同系物2(果蝇)泛素羧基端酯酶L1(泛素硫酯酶)A激酶(PRKA)锚蛋白质(gravin)12脂肪分化相关蛋白质钙通道；电压依赖性；β3亚基cAMP反应性元件结合蛋白质样1软骨素4-磺基转移酶染色体20开放阅读框33COP9组成型光形态形成同系物亚基7B(拟南芥)细胞周期蛋白依赖性蛋白激酶抑制剂2A(黑素瘤；p16；抑制CDK4)细胞质FMR1互作蛋白质2DKFZP434C245蛋白质成纤维细胞生长因子5H2B组蛋白家族；成员JHSPC144蛋白质HT021HTPAP蛋白质羟甲基胆汁合酶假定蛋白质dJ465N24.2.1假定蛋白质DKFZp762L0311假定蛋白质FLJ11113假定蛋白质FLJ20280假定蛋白质FLJ21839假定蛋白质MGC4707   38.2226875.91549106.219318.236799.3354834.6927196.8807948.30052103.975667.38509106.3248100.6639133.837598.7152186.5768243.35217132.5759145.22760.2377144.6906123.4601116.360578.49388139.085768.4054382.5472587.4371366.49705116.370480.31127   349260203381526197292219364182227193192179115471272104259428348276109188152110178143258170   1302.6692525.644590.26221219.9533302.631656.46753028.5081523.166229.1446146.1347254.9633217.7521303.01208.0134184.3088355.7426321.634891.06477317.6018271.2983399.4935309.5798177.2043260.8417167.5592169.5379136.6771170.7367323.3964203.9516   563.1937953.7036299.8442539.74711309.293296.02851139.155596.7714232.3779132.005195.985170.529209.7612161.8637128.7341290.1928242.2271113.265212.2747281.3281290.4476233.835121.5622196.1361129.3473120.7311134.1021126.7851232.5844151.3887   5.09E+005.06E+002.47E+006.06E+005.06E+004.24E+004.97E+004.98E+001.14E+001.12E+001.26E+001.11E+001.18E+001.08E+001.09E+003.04E+001.28E+00-6.73E-012.40E+009.07E-011.69E+001.41E+001.17E+009.07E-011.29E+001.04E+006.44E-011.36E+001.47E+001.34E+00   3.19E+001.77E+009.35E-014.39E+002.40E+002.50E+001.59E+002.18E+001.81E+001.44E+001.09E+009.40E-015.24E-018.58E-014.14E-013.44E+001.04E+00-4.89E-012.10E+001.56E+001.50E+001.24E+004.74E-014.38E-011.15E+004.16E-011.03E+001.11E+001.15E+001.08E+00   888888884444444444444444444444   腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int/I增加腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开
  Q9H765Q14157Q9Y2D8Q9H6Z3Q99748Q9NVD7O43175Q9Y253P24158Q9UBK7Q13636Q9UIC2Q9NVQ7O75368O95863Q9UL01Q16226P07996Q99081O95922P15036O95337Q9H1B5P55263P51648P50995P12429P05026P00751Q9HA23   I15gh6N23gh1A07ef8E24gh5J24ab8D11gh3H24cd6E24cd1M05ef5M21ef3K19cd7L10ef2K12gh3J08cd1N01cd2H01cd8N05cd6A11ef7F10ef6L06ef7H18ef6D04ef8M18gh5K07ab2A22ab2I08ab2I14ab2L22ab2M07ab3E10gh6   假定蛋白质MGC5540KIAA0144基因产物KIAA0923蛋白质驱动蛋白家族成员13Aneurturinparvin；α磷酸甘油酸脱氢酶聚合酶(DNA指导的)；β蛋白酶3(丝氨酸蛋白酶；嗜中性粒细胞；韦氏肉芽肿病自身抗原)RAB；RAS癌基因家族成员样2ARAB31；RAS癌基因家族成员RNB6Sec61α形式2SH3结构域结合富含谷氨酸蛋白质样蜗牛同系物1(果蝇)T细胞识别的鳞状细胞癌抗原硫氧还蛋白互作蛋白质血小板反应蛋白1转录因子12(HTF4；螺旋-环-螺旋转录因子4)微管蛋白酪氨酸连接酶样1v-ets成红细胞病毒E26癌基因同系物2(鸟类)略类似于谷胱甘肽过氧化物酶2木糖基转移酶II腺苷激酶醛脱氢酶3家族；成员A2膜联蛋白A11膜联蛋白A3ATP酶；Na+/K+转运；β1多肽B因子；备解素calponin样跨膜结构域蛋白质   106.394995.1395784.1225111.6382123.748682.6794898.81456108.271587.66238110.987176.3626380.7887982.603692.8251376.5844886.70353111.138479.00174112.229473.12945149.925969.5511181.87715891.66981955.2034888.719711.2353965.7332984.309480.5263   220147237206150140119101280189118171143212134111454139181245114164106720139038701080052902460528   206.6405147.7214206.8269238.8822246.4754230.66192.3326157.8762172.8525313.4316170.0352194.395162.0674196.8753157.9807176.4557529.2322163.2593256.0348253.921383.55955284.3593174.2539299.6337507.37861773.941720.4521976.3671178.473193.0456   177.6046129.9305176.1358185.578173.2957151.1753136.6151122.2465180.0275204.6287121.5169148.7422129.1434167.1823122.817124.5829364.6675127.0819182.9347190.8311115.8531172.7489120.5878637.1981284.0463511.8437424.3513744.9622206.568400.5912   9.58E-016.35E-011.30E+001.10E+009.94E-011.48E+009.61E-015.44E-019.80E-011.50E+001.15E+001.27E+009.72E-011.08E+001.04E+001.03E+002.25E+001.05E+001.19E+001.80E+00-8.43E-012.03E+001.09E+00-1.57E+00-1.95E+00-1.46E+00-2.50E+00-1.00E+00-1.34E+00-1.32E+00   1.05E+006.27E-011.50E+008.85E-012.74E-017.62E-012.64E-01-1.06E-011.67E+007.72E-016.30E-011.08E+007.89E-011.19E+008.06E-013.51E-012.03E+008.15E-016.86E-011.75E+00-3.94E-011.24E+003.68E-01-3.08E-01-4.93E-01-3.36E-011.59E-014.16E-01-2.81E-011.36E-01   4444444444444444444444415151515151515 腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开腺泡关；Int＝I开A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降
  Q16170P25774P21926Q9H2A7O14493P12277Q9NYS7P53355O15205Q9UFZ2P28562Q16690Q9UJW0P00533Q13113P28161Q03013P52594Q9NWT9Q9BZR4Q9BW25P16144P10145Q05084Q9Y484P14923P05783P08727P08729P05787   M17ab3P07ab5J13ef7M19gh5G21ab4M06ab4E20ef4D09ab5D17cd6C23ef8M22ab5B21ab4H10ef1E13gh5A06ef5J02cd5M09ab6L06ab3A18ab7D09gh2L12gh7A19gh6I16ab6O22ef7G10ab7E14cd7M23ef6N06ef6L06ab6N14ef6N16ef6  癌胚抗原相关细胞粘附分子1(胆汁糖蛋白)组织蛋白酶SCD9抗原(p24)趋化因子(C-X-C基序)配基16claudin 4肌酸激酶；脑包含CS盒的WD蛋白质死亡相关蛋白质激酶1双泛素DKFZP564K247蛋白质双特异性磷酸酶1双特异性磷酸酶5动力蛋白激活蛋白4(p62)外核苷酸焦磷酸酶/磷酸二酯酶5(推断功能)表皮生长因子受体(成红细胞白血病病毒(v-erb-b)癌基因同系物；鸟类)癌中上调的上皮蛋白质；膜结合蛋白质17谷胱甘肽S转移酶M2(肌肉)谷胱甘肽S转移酶M4HIV-1Rev结合蛋白质假定蛋白质FLJ20607假定蛋白质HT036假定蛋白质MGC3101整联蛋白；β4白细胞介素8胰岛细胞自身抗原1(69kD)JM5蛋白质接合盘状球蛋白角蛋白18角蛋白19角蛋白7角蛋白8   984.7628857.97512011.966650.79611919.128373.8119596.68911325.2437363.3011325.7972077.188485.6475778.5079233.9728263.251613324.191020.341333.2767439.45441062.388748.0681315.4695490.72436902.736600.56711335.2181969.94917317.244025.25811605.4811031.01   12307763500842248061738412601470010601680305662378334155006904654687578444096721330058820102610125002800111007880   212.7712228.9093833.332235.8205799.5104193.0681211.1821558.97562196.358313.5237754.9876155.0161335.9831183.3797182.40442641.961217.4433210.8696252.8058368.3558160.1449150.4768157.311783.339209.1329938.9827912.30812306.177631.84041888.381694.024   807.5766620.93862115.74576.12281732.749394.4895397.32781048.8188102.423900.91091502.864315.2743592.1023265.0097259.758210494.6642.7437336.469386.6697729.2943584.0643291.8079440.04647330.866465.89941429.6251831.61310707.792484.938203.9126867.677   -2.21E+00-1.91E+00-1.27E+00-1.46E+00-1.26E+00-9.53E-01-1.50E+00-1.25E+00-1.75E+00-2.08E+00-1.46E+00-1.65E+00-1.21E+00-3.52E-01-5.29E-01-2.33E+00-2.23E+00-6.60E-01-7.98E-01-1.53E+00-2.22E+00-1.07E+00-1.64E+00-1.95E+00-1.52E+00-5.08E-01-1.11E+00-2.91E+00-2.67E+00-2.62E+00-2.70E+00   3.15E-01-1.45E-018.00E-013.71E-013.70E-017.22E-01-6.35E-01-7.03E-021.00E+00-3.18E-01-3.09E-01-6.70E-01-2.34E-016.91E-013.42E-012.20E-01-5.63E-014.81E-019.00E-02-4.89E-011.74E-013.76E-014.54E-019.47E-01-3.05E-025.93E-014.07E-01-4.70E-01-5.25E-01-6.19E-02-4.86E-01   15151515151515151515151515151515151515151515151515151515151515   A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降
  O14782O005 15P80188Q9UQ53P80294O75394Q9Y376P15941Q16301Q99836P24001Q9C002P25963P00491P49763Q9Y342P43490Q99988Q9UJY1Q9H1C7P51149P51151P15153P52566P01011P05120O14508Q9Y6N5   H22ab6D05ab7D13ab7G02ef3D15gh6M10cd5H18ef2H22ab7H11cd4M07ab7H08cd4O12gh8A16ef1L18ab7O20ef7A13ef2H04cd5B23ef7B05ef3O10gh8A21ef6J22cd4C17ef6I19ef1I08ef7P07ef7M13ef6G13gh4   驱动蛋白家族成员3Cladinin 1lipocalin 2(癌基因24p3)甘露糖(α1；3-)糖蛋白β1；4-N-乙酰葡糖胺糖苷酶；同工酶B金属硫蛋白1H线粒体核糖体蛋白质L33MO25蛋白质粘蛋白1；跨膜髓磷脂转录因子2骨髓分化初级反应基因(88)天然杀伤细胞转录本4食道正常粘膜特异性1B细胞抑制剂中的核因子κ轻链多肽基因增强子；α核苷磷酸化酶胎盘生长因子；血管内皮生长因子相关蛋白质plasmolipin前B细胞集落增强因子前列腺分化因子蛋白激酶H11推断的核蛋白质ORF1-FL49RAB7；RAS癌基因家族成员RAB9A；RAS癌基因家族成员ras相关C3肉毒杆菌毒素底物2(rho家族；GTP结合小蛋白质Rac2)Rho GDP解离抑制因子(GDI)β丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade A(α-1抗蛋白酶；抗胰蛋白酶)；成员3丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade B(卵清蛋白)；成员2STAT诱导的STAT抑制剂-2硫化物脱氢酶样(酵母)   366.35283562.6325234.4351485.546327.8489441.6574860.32252330.6492433.021088.3949232.848605.554938.908820.40155604.053942.55952261.721470.0611836.92711454.743422.131882.687383.0769986.150140450.8924922.821511.844823.7665   6522040907093136664614101250256011107130017700127050012600983173029302080148005250158041878843700382001490871   242.2822824.2377664.0466398.5069208.8705213.7295550.0258487.1995545.0513413.486413531.684423.686605.6118250.45861723.953300.2833651.3251681.8854544.4413062.0142267.107721.6194213.0301352.078910172.442879.818420.453284.0637   420.1772140.6834989.308938.2331300.7815433.794939.64311357.1161844.855871.419644684.1310242.28937.0159523.73836646.258742.0361546.4081694.8131485.8289771.263646.7841393.904338.0922708.682731439.8921999.691139.68659.5107   -5.97E-01-2.11E+00-2.98E+00-1.90E+00-6.50E-01-1.05E+00-6.45E-01-2.26E+00-2.16E+00-1.40E+00-1.86E+00-9.60E-01-6.33E-01-1.71E+00-1.70E+00-1.65E+00-1.80E+00-1.11E+00-1.75E+00-1.90E+00-5.94E-01-1.38E+00-8.47E-01-1.49E+00-1.99E+00-3.11E+00-1.85E+00-1.54E+00   8.31E-01-8.08E-017.93E-01-6.75E-011.57E-015.49E-017.11E-01-8.95E-017.14E-023.15E-025.34E-011.04E+004.32E-01-7.13E-011.17E+006.10E-02-3.90E-019.96E-011.77E-013.69E-016.18E-01-2.55E-011.26E-01-3.24E-011.11E-016.16E-01-2.42E-027.99E-02   15151515151515151515151515151515151515151515151515151515   A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降
  O00161P31431O15533P17987O14746P30408Q9HCN3Q16149Q9Y2A9O60625P07948Q9P2N4P47895P04233Q9NZ31O96002O94907Q92796Q13115P29317P29323Q9UKF9Q9NPD3O43524P21217O75205   C23cd4F24cd1B16ef7E11ef5O20ef6C06ef1E07gh5B15cd1C22ef3N10cd3A21ab7M10gh4C04ab2G09ef1L12gh4G07cd5J15gh6K06ef5O17ab4F02ef5D10ef5H10cd7P22gh2G12ab4M16ab3D24ef2   突触小体相关蛋白质；23kD多配体聚糖4(双栖蛋白聚糖；ryudocan)TAP结合蛋白质(tapasin)t-复合物1端粒酶逆转录酶跨膜4超家族成员1跨膜蛋白质8(5个跨膜结构域)转运蛋白1；ATP结合盒；亚家族B(MDR/TAP)UDP-GlcNAc：βGaIβ-1；3-N-乙酰葡糖氨基转移酶3小泡相关膜蛋白质8(endobrevin)v-yes-1Yamaguchi肉瘤病毒相关癌基因同系物解聚素样及带有1型凝血酶敏感素基序的金属蛋白酶；9醛脱氢酶1家族；成员A3CD74抗原(主要组织相容性复合物的恒定多肽；II类抗原相关)染色体20开放阅读框35染色体X开放阅读框1dickkopf同系物1(非洲爪蟾)discs；大(果蝇)同系物3(神经内分泌-dlg)双特异性磷酸酶4EphA2EphB2ets同源因子外染色体成分Rrp41forkhead盒O3A岩藻糖基转移酶3(半乳糖苷3(4)-L-岩藻糖基转移酶；包括Lewis血型)G蛋白偶联受体；家族C；组1；成员B   1077.8332109.871313.1585495.6787264.868716658.44947.8492862.1561774.55062480.868512.646159.72741247.008229.4566345.4771401.521150.3215161.9581533.5415267.722269.1596603.0262273.527262.2734189.3354621.7284   13403080424298373174001010110043626804432272370174375375200154730279232587300169257382   687.0432887.6687162.3501157.6175151.58456051.147462.0955480.8685153.9485584.39170.174272.96867146.664486.99566137.4415130.731884.5357184.90819146.31282.1525474.35016102.033349.72784102.643560.2480390.93956   1034.0312026.067299.8834317.0491262.986913372.16806.2983813.3307454.84461914.133375.1466153.14951254.954163.6002285.9642302.4558145.044133.5184469.8392209.5143191.9946430.6372207.9117177.9385168.8097364.8596   -6.50E-01-1.25E+00-9.48E-01-1.65E+00-8.05E-01-1.46E+00-1.04E+00-8.42E-01-2.33E+00-2.09E+00-1.59E+00-1.13E+00-3.09E+00-1.40E+00-1.33E+00-1.62E+00-8.30E-01-9.32E-01-1.87E+00-1.70E+00-1.86E+00-2.56E+00-2.46E+00-1.35E+00-1.65E+00-2.77E+00   3.11E-015.46E-014.38E-01-7.35E-014.92E-016.34E-029.01E-023.47E-01-8.29E-011.10E-01-2.12E-015.06E-019.27E-01-3.96E-011.18E-01-9.81E-024.14E-01-7.56E-024.52E-015.78E-02-2.11E-01-3.92E-021.36E-01-6.35E-014.40E-01-7.03E-01   1515151515151515151515141414141414141414141414141414   A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I降A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关
  O75712Q92908O95210O95395P48506Q9UI98Q9H6D8P05362Q07627Q9BYQ7O75071Q9UPQ2O43896Q13887O00312O15264Q9UHA4P21397P55196Q12965Q9HBW1Q9H2W4Q9NRR3P23511Q99650P04085Q13048   A03ef1D12ab4P05cd4K21cd5F22ab5F08ef8D18gh5I02ab6J20gh7D10gh8F15gh1G22ef8H10cd6L05ab5D22cd3H07ab8P10gh1F23ef6N07ab7I24ab7O10gh7D20gh6O06gh4M19ab8D14cd4O16ef7N06cd2   间隙连接蛋白；β3；31kD(连接蛋白31)GATA结合蛋白质6genethonin 1葡糖胺酰(N-乙酰)转移酶3；粘蛋白型谷氨酸-半胱氨酸连接酶；催化亚基hqp0256蛋白质假定蛋白质FLJ22362细胞间粘附分子1(CD54)；人鼻病毒受体角蛋白相关蛋白质1.1角蛋白相关蛋白质4.10KIAA0494基因产物KIAA1100蛋白质驱动蛋白家族成员1CKruppel样因子5(肠)MAP激酶互作丝氨酸-苏氨酸激酶1促分裂原活化蛋白激酶13促分裂原活化蛋白激酶激酶1互作蛋白质1单胺氧化酶A骨髓/淋巴或混合性白血病(三空腔同系物；果蝇)；已易位；4肌球蛋白IENAG14蛋白质神经前体细胞表达的；发育上下调的4样非激酶Cdc42效应子蛋白质SPEC2核转录因子Y；α制瘤素M受体血小板源性生长因子α多肽妊娠特异性β-1糖蛋白4   235.3139293.117331.9855297.4236299.1944357.587542.6184411.0131288.3566493.4934240.2512224.7248159.6982494.1259147.9629213.7425268.8101427.3495164.9238212.4935417.9837361.6431194.8075239.2485337.1614441.7554149.7737   402199241274243336595424303605167349170376150160244480168276396463327226233463203   145.546693.59788112.6945.82301134.9982106.803127.429967.8001640.2857196.5113791.77931135.681173.4492497.4305486.6069576.3206972.5004230.4264578.62952122.001586.8439875.41197117.0936132.3351141.0848124.479384.53571   260.8655195.3976228.6851205.5863225.879266.8154421.5312301.0074210.3957398.2261166.3595236.4102134.4385322.6178128.2701150.0667195.0133312.5207137.1449203.3655300.2834299.9778213.1256199.2783237.114343.2015145.8869   -6.93E-01-1.65E+00-1.56E+00-2.70E+00-1.15E+00-1.74E+00-2.09E+00-2.60E+00-2.84E+00-2.35E+00-1.39E+00-7.28E-01-1.12E+00-2.34E+00-7.73E-01-1.49E+00-1.89E+00-3.81E+00-1.07E+00-8.01E-01-2.27E+00-2.26E+00-7.34E-01-8.54E-01-1.26E+00-1.83E+00-8.25E-01   7.72E-01-5.55E-01-4.60E-01-1.21E-01-2.97E-01-8.96E-021.32E-014.56E-026.93E-022.93E-01-5.24E-016.34E-019.16E-02-3.93E-012.20E-02-4.17E-01-1.41E-011.67E-012.56E-023.75E-01-7.79E-023.56E-017.49E-01-8.06E-02-5.33E-016.89E-024.41E-01   141414141414141414141414141414141414141414141414141414   A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关
  P10586O95200Q9NVX8Q15418Q15434Q15437O60679Q12890Q12971P78556O75751Q9UM01Q9Y5X1P08842O43760O75674P01135Q9NT70O60656Q9NZ42O76080Q13015P04083O60592Q07814Q14201Q9NR00Q9BUW7   E11ef6N22ab8P17ef3N14ef5F10ab8O10cd6D15ef5N06ef5L03cd6M02cd2F14ef4D08cd4D10ef2D19ab3G09cd5N15cd5K04eF7K13gh3G13gh3N18gh4E14cd4H11ab2I06ab2B14ab2E04ef6E17cd7J21gh4K19gh6   蛋白酪氨酸磷酸酶；受体型；F视黄酸受体反应物(tazarotene诱导的)3Rho GTP酶活化蛋白质8核糖体蛋白质S6激酶；90kD；多肽1RNA结合基序；单链互作蛋白质2Sec23同系物B(酿酒酵母)血清可诱导性激酶SFRS蛋白激酶1唾液酸转移酶可诱导小细胞因子亚家族A(Cys-Cys)；成员20溶质载体家族22(extraneuronal单胺转运蛋白)；成员3溶质载体家族7(阳离子氨基酸转运蛋白；γ+系统)；成员7分选连接蛋白9类固醇硫酸酯酶(微粒体)；芳香硫酸酯酶C；同工酶S突触孔蛋白2myb1靶样1(鸡)转化生长因子；α跨膜蛋白质vezatinUDP糖基转移酶1家族；多肽A9非特征性造血干/祖细胞蛋白质MDS033锌指蛋白216来自染色体1q的ALL1融合基因膜联蛋白A1Arg/Abl互作蛋白质ArgBP2BCL2相关的X蛋白质BTG家族；成员3染色体8开放阅读框4染色体9开放阅读框16   466.2876437.2899425.2848299.528454.6438281.2005202.0368350.4057247.3141308.0437164.6419201.657219.1839436.4255391.0545276.5234215.9023365.9385546.3937196.9377314.9706329.60611114.4861576.114430.8903197.86082766.931228.4878   4053154793613282351942783293822382602404142382851604014382132111730824033208624517310650   136.671872.62859109.254178.38666145.2438126.958262.20916113.042896.9100259.3132566.8359355.89528108.9101136.2997118.116754.3235359.63082129.260727.51254115.273774.565411752.98292.2452017.8361101.457419.43783283.111551.4272   335.8682275.0752337.8544246.2347309.3377214.4633152.8498247.1823224.3379249.7105156.4431172.4611189.2981328.904249.1866205.2456145.3108298.7991337.3961175.1842200.07681272.1385883.7872304.427797.9572355.94964453.955476.5934   -1.77E+00-2.59E+00-1.96E+00-1.93E+00-1.65E+00-1.15E+00-1.70E+00-1.63E+00-1.35E+00-2.38E+00-1.30E+00-1.85E+00-1.01E+00-1.68E+00-1.73E+00-2.35E+00-1.86E+00-1.50E+00-4.31E+00-7.73E-01-2.08E+002.41E+002.90E+003.56E-011.35E+001.08E+002.47E-011.27E+00   -2.05E-01-4.72E-011.72E-012.68E-01-4.70E-01-2.58E-01-5.63E-02-3.33E-014.11E-013.10E-015.31E-013.66E-011.30E-01-7.62E-02-7.14E-014.30E-02-4.29E-011.33E-01-3.18E-011.15E-01-5.80E-012.40E+002.89E+001.07E+001.00E+001.19E+001.40E+001.51E+00   1414141414141414141414141414141414141414146666666 A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关A/Int开；I关腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升
  O95401Q00535P21741Q9Y291O75376P03973O15427P16949Q9NZ86O00748Q13630P00505P50440P29622O14646P48307Q15125P19387Q9P0K7P30086Q13045O95084P49770   N04cd4B09ef5E17ab7J15ef2E17cd6N10cd1F06cd4D11ab7J08gh3H07cd4M01cd3C14ab6A09ab5A06cd1C17ab4I10cd4D08cd6B13ab8H08gh6E04ab8C06ab5G10cd7L11ef4   Sp1转录活化所需辅因子；亚基8(34kD)细胞周期蛋白依赖性蛋白激酶5肝素结合细胞因子(轴突生长促进因子2)线粒体核糖体蛋白质S33细胞核受体辅阻遏物1分泌型白细胞蛋白酶抑制剂(antileukoproteinase)溶质载体家族16(一元羧酸转运蛋白)；成员3stathmin 1/癌蛋白18非特征性骨髓蛋白质BM036羧酸酯酶2(肠；肝)组织特异性移植抗原P35B谷氨酸-草酰乙酸转氨酶2；线粒体(天冬氨酸转氨酶2)甘氨酸转氨酶(L-精氨酸：甘氨酸转氨酶)丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade A(α-1抗蛋白酶；抗胰蛋白酶)；成员4染色质域解旋酶DNA结合蛋白质1组织因子通道抑制剂2emopamil结合蛋白质(固醇异构酶)聚合酶(RNA)II(DNA指导的)多肽C(33kD)视黄酸诱导的14前列腺结合蛋白质不能飞的I同系物(果蝇)蛋白酶；丝氨酸；23真核翻译起始因子2B；亚基2(β；39kD)   186.3494269.74952991.463177.4689375.3679592.855228.58728.2643311.37541080.553622.3905494.08781737.906461.3518867.7631920.3007897.4306196.4282177.983634.2686622.70721096.756731.6826   39547615400330127020707532630945220287356395189180366230155275462501246547   588.6133432.11769802.656365.4484727.38364153.51785.89751984.807536.938253.3623255.576260.2263261.2318264.9574273.1703277.6619282.4317282.8549283.8007300.6211306.0777314.746329.7361   390.063392.6299388.855290.8529791.93812270.718589.01751781.654597.7198517.9952388.1959369.968798.1958304.9848440.3418521.385470.0852211.5128245.4643465.627476.5407552.6166536.2071   1.66E+006.80E-011.71E+001.04E+009.54E-012.81E+001.78E+001.45E+007.86E-01-2.09E+00-1.28E+00-9.25E-01-2.73E+00-8.00E-01-1.67E+00-1.73E+00-1.67E+005.26E-016.73E-01-1.08E+00-1.02E+00-1.80E+00-1.15E+00   1.08E+008.19E-012.36E+008.93E-011.76E+001.80E+001.72E+001.85E+001.60E+00-2.30E+00-1.12E+00-4.75E-01-2.14E+00-1.29E+00-2.27E+00-1.33E+00-1.96E+00-3.39E-016.26E-01-4.57E-01-3.14E-01-2.15E+00-4.19E-01   6666666662020202020202020202020202020 腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升腺泡开；Int＝I升其它其它其它其它其它其它其它其它其它其它其它其它其它其它
  Q13948Q30201P52895Q9Y5N1P43378P35414Q14802Q9Y266P30043Q9NP73Q12972Q9Y296Q02750P42226P31947P46597O14745Q9NS67Q9UKL5Q9UQL3Q9NZZ1Q9Y3Q3Q9NSN3Q9Y5Z0O14713   J02ef6H05ab3I16gh6M24cd7N23ab8O11ab2K03cd1F16cd6O21ab3L06gh3D17ab8N21ef2K02ef7G23cd2M07ef6J12ab2J24cd4D24gh1J07cd8B11ef2P18ef2H03cd7C10gh4B12cd7C21gh7M11cd5   cut-like 1；CCAAT替代蛋白质(果蝇)血色素沉着病醛-酮还原酶家族1；成员C2(二氢二醇脱氢酶2；胆汁酸结合蛋白质；3-α羟甾醇脱氧酶；III型)组胺受体H3蛋白酪氨酸磷酸酶；非受体9型血管紧张肽受体样1包含FXYD结构域的离子转移蛋白调节子3核分布基因C同系物(构巢曲霉)胆绿素还原酶还原酶(黄素还原酶(NADPH))非特征性造血干/祖细胞蛋白质MDS031蛋白磷酸酶1；调节(抑制剂)亚基8PTD009蛋白质促分裂原活化蛋白激酶激酶1信号传导子及转录激活子6；白细胞介素4诱导stratifin乙酰血清素O-甲基转移酶溶质载体蛋白家族9(钠/氢交换物)；同工型3调节因子1G蛋白偶联受体27程序性细胞死亡6互作蛋白质肝特异性bHLH-Zip转录因子假定蛋白质HSPC138整合I型蛋白质类似于天冬氨酸β羟化酶(ASPH)β位点APP裂解酶2H2B组蛋白家族；成员B整联蛋白细胞质结构域相关蛋白质1   222.2758205.16074001.572526.51331360.729620.70392174.215745.3985877.8813804.2103251.1796738.5086810.206892.60252941.1972225.9441844.7191464.475995.6375825.7324397.5554526.2023355.13051469.687511.589446.3806   3492912632034454067114475654463584245085167414376423818861150450355273960855746   330.5149339.4607339.7988341.1301368.4734395.8948402.87408.3037417.1383421.5183425.52436.6114441.4249450.4229452.267466.9229504.4269595.0192605.9272606.7901618.4035631.4284667.4052680.3343733.4035737.9643   300.5112278.4461534.634356.7517724.8175474.23451096.127533.6949620.0433557.2055345.0523532.9995586.6635619.55681378.2051043.272997.106813.4043829.3129860.8974488.5944504.2124431.85281036.811699.9713643.5596   5.72E-017.26E-01-3.56E+00-6.26E-01-1.88E+00-6.49E-01-2.43E+00-8.68E-01-1.07E+00-9.32E-017.61E-01-7.58E-01-8.76E-01-9.87E-01-2.70E+00-2.25E+00-1.87E+00-1.30E+00-7.16E-01-4.44E-016.37E-012.63E-019.10E-01-1.11E+005.20E-017.25E-01   6.50E-015.03E-01-3.93E+00-1.38E+00-1.61E+00-6.12E-01-1.61E+00-7.37E-01-6.35E-01-8.51E-015.13E-01-8.01E-01-6.72E-01-7.92E-01-1.99E+00-2.35E+00-1.52E+00-1.94E+00-1.68E-014.78E-011.78E-01-5.68E-01-3.79E-01-6.14E-017.41E-017.42E-01   2020202020202020202020202020202020202020202020202020   其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它
  P46095Q9BV10Q99653P41584P11940Q00341Q16795Q13082P36405Q9NXH2Q9Y323P48059Q9P0M9Q13813Q9Y379Q13247P14416Q06323Q9NR31P05451P04075Q15904P15559O00303P56705P39210   P11ab4K07gh6O08cd7P16gh1E06ab8G21ab6K08ab7E05ab7D16ab2C04gh2D21ef2I12ab7M02ef2E07cd2H07ef2O13gh1D03ef6A15ef7H17gh4C07cd3C12ab2A19ab3G24ef7L20cd3M01gh7I04ef7   G蛋白偶联受体6假定蛋白质MGC3136钙结合蛋白质P22聚合酶(RNA)II(DNA指导的)多肽F多聚(A)结合蛋白质；细胞质部分1高密度脂蛋白结合蛋白质(vigiIin)NADH脱氢酶(泛醌)1α子复合物；9(39kD)微管相关蛋白质4ADP核糖基化因子样3假定蛋白质FLJ20254假定蛋白质HSPC177LIM和衰老细胞抗原样结构域1线粒体核糖体蛋白质L27血影蛋白；α；非红细胞1(α-胞影蛋白)CGI-69蛋白质剪接因子；富含精氨酸/丝氨酸6多巴胺受体D2蛋白酶体(前体；macropain)活化子亚基1(PA28α)SAR1蛋白质再生胰岛来源的1α(胰石蛋白；胰thread蛋白)醛缩酶A；果糖二磷酸ATP酶；H+转运；溶酶体(空泡质子泵)；亚基1NAD(P)H脱氢酶；醌1真核翻译起始因子3；亚基5(ε；47kD)无翼型MMTV整合位点家族；成员4MpV17转基因；小鼠同系物；肾小球硬化症   2336.8411761.6271713.549560.10661738.585545.58441582.8721217.396508.3031515.6731838.9663560.9674579.00832261.5922556.713718.1614814.53511491.803752.634375644.124534.199833.0193537.08921243.8053589.752990.336   4606531430892669444119047254746716309189368861900121074523508861690159013803036361590894   760.4217779.7338793.2383821.9856827.8343866.5328873.0478873.8683939.7284959.9781976.22421003.9451024.3591070.9841174.1071194.9511299.031386.7191386.8491394.4251470.9671471.7991486.451556.4481635.8051723.06   1185.9181064.8151313.03758.04271078.525618.57131214.409854.4272665.1099647.42691148.545827.7691846.58011406.1071877.9391041.827952.94391742.3771008.64626243.722532.661228.765775.57351145.3772271.3641202.587   -1.62E+00-1.18E+00-1.11E+005.53E-01-1.07E+006.67E-01-8.58E-01-4.78E-018.87E-018.97E-012.19E-018.40E-018.23E-01-1.08E+00-1.12E+007.35E-016.73E-01-1.05E-018.82E-01-5.76E+00-1.62E+008.21E-011.47E+003.23E-01-1.13E+007.99E-01   -2.34E+00-1.43E+00-2.59E-016.71E-01-1.38E+00-2.99E-01-4.15E-01-1.37E+001.07E-01-1.44E-019.59E-017.11E-016.93E-01-1.35E+00-4.26E-017.55E-01-1.28E-016.55E-012.36E-01-5.48E+00-1.51E+007.30E-01-8.25E-01-9.68E-01-1.18E+00-1.47E-01   2020202020202020202020202020202020202020202020202020   其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它
  Q9UKL9O43516Q9Y470P29312Q9Y5R8P17676O95362O60417P19623Q9P039Q9BUF5P00995P11142P10620Q13347P15880Q9HCU0Q04941Q9UPI1P13987P15951P04687P04687Q9UI09   N03ef4E12cd3D01ef7H12cd4P24gh4D01ab5F11gh6C11gh7E17cd2P02ef7F05gh8C23cd2E22ef7E16ef7N02cd3B16cd1E24gh4O16ab8M14cd2B18ef7N04cd2P12cd1H12cd1L02gh4   醛-酮还原酶家族1；成员C3(3-α羟甾醇脱氢酶；II型)维-奥二氏综合征蛋白质互作蛋白质干细胞生长因子；淋巴细胞分泌的C型凝集素酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；ζ多肽MUM2蛋白质CCAAT/增强子结合蛋白质(C/EBP)；β在造血系中差异表达S100钙结合蛋白质A14(calgizzarin)精脒合酶包含FXYD结构域的离子转移蛋白调节子5微管蛋白β-5丝氨酸蛋白酶抑制剂；Kazal 1型热休克70kD蛋白质8微粒体谷胱甘肽S-转移酶1真核翻译起始因子3；亚基2(β；36kD)核糖体蛋白质S2肿瘤内皮标志1前体蛋白脂质蛋白质2(结肠上皮富含)核内小分子核糖核蛋白D2多肽(16.5kD)CD59抗原p18-20(由单克隆抗体16.3A5；EJ16；EJ30；EL32和G344鉴定的抗原)蛋白酶；丝氨酸；3(胰蛋白酶3)微管蛋白；α；遍在的微管蛋白；α；遍在的13kDa分化相关蛋白质   16311.311162.5111346.6935187.7661596.0326064.06810407.526955.6421644.2662410.082252.62367989.2111154.996706.73619633.034356.013139.14517951.734625.51517383.1774972.4615943.8215832.931754.698   284011901110471017502880268056901020212015801130078402430521020602600118008280192007610726075901990   1896.1021979.2462049.5422331.8542568.1132723.6882912.1583097.5793417.9784486.0294730.7555416.1755433.8435571.4115660.7575964.9937148.0758567.7368998.78710453.4311417.515413.4424085.352889.148   7016.7961444.291503.5564076.2471971.0953890.6765333.1025248.9392027.6433004.6272855.74428226.588144.6014901.59510168.914127.4374295.78412775.937300.38715673.3831332.7412871.6715834.492210.196   -3.10E+007.68E-016.06E-01-1.15E+006.86E-01-1.15E+00-1.84E+00-1.17E+001.06E+008.96E-011.07E+00-3.65E+00-1.04E+00-2.68E-01-1.79E+004.54E-011.19E+00-1.07E+009.60E-01-7.34E-01-2.72E+00-4.88E-026.05E-017.19E-01   -2.52E+003.51E-02-2.73E-01-1.40E-011.32E-01-1.07E+00-1.96E+00-2.89E-01-6.88E-01-1.87E-01-5.08E-01-2.59E+00-5.08E-01-1.47E+00-1.91E+00-1.08E+00-2.72E-01-6.04E-018.39E-011.42E-01-3.30E+00-1.14E+00-1.06E+001.79E-01   20202020202020202020202020202020202020202020203   其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它其它恒高
  Q9Y6H1Q9P0U1P80095Q92747O15144O15145P02570P02570P02570P02571P12814O43707P53999P18848P53680P29274P54819Q01518P32889P18085P26437Q9BZX4P11766P05067Q06481P07355P08758   E23ef2C07gh3N10ab7F04ab2F08ab2F10ab2A01cd7H12cd7P12cd7A06ab6E23ab2G05ab2C05cd7I03ef5A07ef1A18ef5A04ab2O18cd6C03ef6P21ab2B02ab2L08gh6K01ab2N03ef6K22ab2I12ab2I18ab2   16.7Kd蛋白质6.2kd蛋白质6-丙酮酰基四氢生物蝶呤合酶/肝细胞核因子二聚化辅因子1α(TCF1)肌动蛋白相关蛋白质2/3复合物；亚基1A(41kD)肌动蛋白相关蛋白质2/3复合物；亚基2(34kD)肌动蛋白相关蛋白质2/3复合物；亚基3(21kD)肌动蛋白；β肌动蛋白；β肌动蛋白；β肌动蛋白；γ1辅肌动蛋白；α1辅肌动蛋白；α4活化的RNA聚合酶II转录辅因子4转录激活因子4(tax反应性增强子元件B67)接头相关蛋白质复合物2；σ1亚基腺苷A2a受体腺苷酸激酶2腺苷酸环化酶相关蛋白质ADP核糖基化因子1ADP核糖基化因子4ADP核糖基化因子5AKAP-结合精蛋白ropporin乙醇脱氢酶5(III类)；X多肽淀粉状蛋白β(A4)前体蛋白质(蛋白酶微管连接蛋白-II；阿尔茨海默病)淀粉状蛋白β(A4)前体样蛋白质2膜联蛋白A2膜联蛋白A5   5687.3332323.4023223.9224894.40113976.763065.88166304.8164949.7421347.3669165.162400.6076999.1384478.9867160.8882255.2351990.1242997.6076946.7886040.7964777.9043739.4772345.4552220.1562846.852117.65274767.394487.905   40501990262039902140031904540042400122005910021603810432054202530296025201100072208880443027801990418032301120004270   5837.943847.5861569.693030.01817206.311793.81338777.9244598.6615408.6165677.152638.0113499.2346009.3187668.2864102.6332004.5962851.7397171.2057907.028342.1653984.8452500.1182854.3183918.5952290.19197217.177134.202   5191.6282721.4392471.5923972.8917538.092683.63850171.4150643.4416331.8564643.452400.8444769.1964936.986749.8732963.4232318.3672788.38362.3757056.8517331.814052.2622541.0662354.2473649.5582546.59894734.135295.976   3.77E-027.28E-01-1.04E+00-6.92E-013.00E-01-7.73E-01-7.74E-01-5.42E-01-4.70E-01-7.47E-021.36E-01-1.00E+004.24E-019.88E-028.63E-011.05E-02-7.20E-024.59E-023.88E-018.04E-019.17E-029.21E-023.62E-014.61E-011.13E-013.79E-016.69E-01   -4.90E-01-2.21E-01-2.99E-01-2.93E-016.17E-015.78E-02-5.45E-01-6.16E-01-8.03E-01-2.27E-01-1.50E-01-8.78E-01-5.13E-02-4.02E-011.67E-015.73E-01-2.53E-016.59E-012.58E-018.93E-012.45E-012.44E-01-1.59E-015.55E-016.10E-015.86E-01-7.32E-02   333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P55064Q13520P32391O43776P24539P48201P05496Q06055O75947P56385P56134P18859O75964P25705P06576P36542P48047   O08ab2O10ab2D19ab2E18ab7N22ab2P04ab2N24ab2P02ab2P14ab2P06ab2P10ab2P08ab2P16ab2N14ab2N16ab2N18ab2P18ab2   水通道5水通道6；肾特异性ARP3肌动蛋白相关蛋白质3同系物(酵母)天冬酰胺酰-tRNA合成酶ATP合成酶；H+转运；线粒体F0复合物；亚基b；同工型1ATP合成酶；H+转运；线粒体F0复合物；亚基c(亚基9)同工型3ATP合成酶；H+转运；线粒体F0复合物；亚基c(亚基9)；同工型1ATP合成酶；H+转运；线粒体F0复合物；亚基c(亚基g)；同工型2ATP合成酶；H+转运；线粒体F0复合物；亚基dATP合成酶；H+转运；线粒体F0复合物；亚基eATP合成酶；H+转运；线粒体F0复合物；亚基f；同工型2ATP合成酶；H+转运；线粒体F0复合物；亚基F6ATP合成酶；H+转运；线粒体F0复合物；亚基gATP合成酶；H+转运；线粒体F1复合物；α亚基；同工型1；心肌ATP合成酶；H+转运；线粒体F1复合物；β多肽ATP合成酶；H+转运；线粒体F1复合物；γ多肽1ATP合成酶；H+转运；线粒体F1复合物；O亚基(寡霉素敏感性赋予蛋白质)   10851.572404.7484291.8232570.9682908.6975694.1822176.3785784.5792668.0282682.79811587.913879.9392021.5913657.5124072.9782479.54222.314   1420023504280301038004370176035302520209017200484026302410328020304100   11650.242457.2783941.052854.9893228.2034857.9552400.5757732.5521881.9742616.72614181.185176.5852009.0262967.2072557.9622436.2843541.047   12248.872404.3974171.0132811.6343312.7174974.1352112.6285682.6092355.8582462.52414327.124633.5592219.113009.9153305.0472313.9893955.838   1.02E-013.12E-02-1.23E-011.51E-011.50E-01-2.29E-011.41E-014.19E-01-5.04E-01-3.60E-022.91E-014.16E-01-8.99E-03-3.02E-01-6.71E-01-2.54E-02-2.54E-01   3.93E-01-3.25E-02-3.92E-032.27E-013.86E-01-3.82E-01-3.06E-01-7.12E-01-8.37E-02-3.62E-015.71E-013.20E-013.78E-01-6.05E-01-3.11E-01-2.91E-01-4.09E-02   33333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q01814Q99437P36543O75348Q16864P27449O00244O14503O60238P30536P01884P22004O95415O75531P02593P07384P27797P47756P15086P52952P13862O14675P35221P07858   P01ef5A11ab3A09ab3A15ab3A21ab3A05ab3L14ab2M19ab3L11ab5L21ab3C23ab3I13ab5B02ef3K11ab3A10ab6O24ef1P05ab5N06gh8N14ab4H13ab5D22ab5M21ef1I02ef6C17ef7E01ab5   ATP酶；Ca++转运；质膜2ATP酶；H+转运；溶酶体(空泡质子泵)21kDATP酶；H+转运；溶酶体(空泡质子泵)31kDATP酶；H+转运；溶酶体13kD；V1亚基G同工型1ATP酶；H+转运；溶酶体14kD；V1亚基FATP酶；H+转运；溶酶体16kD；V0亚基cATX1抗氧化剂蛋白质1同系物(酵母)包含碱性螺旋-环-螺旋结构域；B类；2BCL2/腺病毒E1B 19kD互作蛋白质3样苯并二嗪受体(外周)β-2微球蛋白骨形态发生蛋白质6脑蛋白质13断裂点簇集区蛋白质；子宫平滑肌瘤；1；自身整合因子屏障钙调蛋白2(磷酸化酶激酶；δ)钙蛋白酶1；(μ/I)大亚基钙网织蛋白CaM-KII抑制蛋白质加帽蛋白(肌动蛋白丝)肌肉Z线；β羧肽酶B1(组织)心特异性同源异形盒酪蛋白激酶2；β多肽CASP8和FADD样凋亡调节子连环蛋白(钙粘蛋白相关蛋白质)；α1(102kD)组织蛋白酶B   3157.4472495.6181854.1982734.4846452.2917134.142833.9574978.9161473.4281997.929648725036.9857498.7342541.7891573.773429.13210259.4220298.714348.0799766.0622859.1973674.9212622.5863813.5162480.797   318038702920566015900243003500428024202890105000471011200274041303420970028200445027.117403840250042303860   3242.7072087.2911659.7492721.8787960.23413120.573977.5473254.6313224.1412326.21136055.953780.0055348.842924.8264742.4852390.01115437.3521760.795015.37726.971292282.5463873.2281151.6613300.7384485.422   3193.5352817.8032145.9083704.4210101.5918185.043435.6754169.7612371.4072405.62568478.914509.3178032.2952736.9923482.2153078.32411797.3323425.994604.93273.3782292.943795.2822092.2293782.7723607.853   3.84E-02-2.58E-01-1.60E-01-6.67E-033.03E-01-3.85E-014.89E-01-6.13E-011.13E+002.19E-01-8.47E-01-4.14E-01-4.87E-012.03E-011.59E+00-5.21E-015.89E-011.00E-012.06E-01-8.50E+00-3.25E-017.58E-02-1.19E+00-2.08E-018.54E-01   1.05E-026.33E-016.57E-011.05E+001.30E+005.04E-013.03E-01-2.20E-017.14E-015.34E-016.88E-01-9.65E-025.85E-011.11E-011.39E+00-5.61E-03-8.16E-024.75E-013.38E-02-8.49E+00-7.19E-016.25E-02-6.77E-021.51E-016.37E-01   3333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P48509P25063P16070P08962O14519P25763P49368P48643O00299Q9Y2Q7P09496O95832O95471P23528P16989P38936Q9UII4P04080P21291O00622P13073P12074Q02221P14854P09669P14406O14548P24311   K16ab4G22cd8O21ef1O18ab4K04ef5A12ab6N17cd2H10ef4M19ab6N02cd8F15ab5L04gh1A13ef1M20ab5L08ef6O21ef5B14ef1G16ab3J01ab5J15ef7L19ab5K13gh1E17ab6A20ab6E12ab6G02ab5G23cd5K17ab5 CD151抗原CD24抗原(小细胞肺癌簇集4抗原)CD44抗原(归巢功能及Indian血型系统)CD63抗原(黑素瘤1抗原)CDK2相关蛋白质1细胞分裂周期(GTP结合蛋白质；25kD)包含伴侣蛋白的TCP1；亚基3(γ)包含伴侣蛋白的TCP1；亚基5(ε)氯离子细胞内通道1染色体11开放阅读框10网格蛋白；轻链多肽(Lca)claudin 1claudin 7cofilin 1(非肌肉)冷休克蛋白质A细胞周期蛋白依赖性蛋白激酶抑制剂1A(p21；Cip1)细胞周期蛋白E结合蛋白质1半胱氨酸蛋白酶抑制剂B(stefin B)富含半胱氨酸和甘氨酸蛋白质1富含半胱氨酸；血管原性诱导剂；61细胞色素c氧化酶亚基IV同工型1细胞色素c氧化酶亚基VIa多肽1细胞色素c氧化酶亚基VIa多肽2细胞色素c氧化酶亚基VIb细胞色素c氧化酶亚基VIc细胞色素c氧化酶亚基VIIa多肽2(肝)细胞色素c氧化酶亚基VIIa多肽2样细胞色素c氧化酶亚基VIIb   7267.5621319.2716178.969354.9144231.1914588.8192356.6272238.9336811.554087.3615758.6323046.3762888.81916021.952942.7233643.1826180.84312.1682478.3662070.2036219.6283253.242968.241991.912580.5984846.7132182.9543224.558   137001820096401160041802840288023307240380092602450335018700253042502980054201710162085505800282026602090450024505150   8768.7318278.9735778.64210016.294763.0132852.1862222.3611561.6255727.1215946.2595849.641918.08381520.97714063.432069.1843437.07639655.022370.132135.862978.5426571.8484244.5574604.2412380.7951927.0024245.4783040.5863801.752   9901.7115932.7910533.4310307.14389.9953426.7362484.9392042.126591.2994610.9426957.3412138.3832587.17716255.642515.2123777.5731877.44034.2722109.0962224.3397115.0484434.133464.9042344.3312197.584530.3462556.4814057.995   2.71E-01-1.36E+00-1.49E+009.86E-021.71E-01-6.86E-01-8.46E-02-5.20E-01-2.50E-015.41E-012.26E-02-1.73E+00-9.25E-01-1.88E-01-5.08E-01-8.40E-025.99E-01-8.63E-01-2.15E-015.25E-017.95E-023.84E-016.33E-012.57E-01-4.21E-01-1.91E-014.78E-012.38E-01   9.11E-01-2.28E-01-7.47E-013.04E-01-1.90E-02-6.93E-012.87E-015.49E-028.71E-02-1.05E-016.86E-01-3.14E-012.14E-012.22E-01-2.16E-012.23E-011.87E-013.30E-01-5.33E-01-3.50E-014.60E-018.35E-01-7.28E-024.17E-01-3.08E-01-1.07E-011.64E-016.75E-01   3333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P15954P10176O43293P46966Q09753P18282P07108P31689Q9Y5T4Q9Y463Q9NP97Q15701P78545O60869Q14259P06733P22712P04720P26641P13639O15372O75821Q64252O15371P04765Q14240P10159   P04ab5B10ab5K19ab4G14ef6G01ab6F23ab2H04gh1D18ab7I10cd8G15cd5C02ef8L08cd3O16ab4A03cd4L06ab4C16ab4D11gh6O07ab6A10ab4I15ab5L24cd3L22cd3L11ab6L18cd3A22ab4H13ab4A18ab5   细胞色素c氧化酶亚基VIIc细胞色素c氧化酶亚基VIII死亡相关蛋白质激酶3细胞死亡防御物1防卫素；β1destrin(肌动蛋白解聚因子)安定结合抑制剂(GABA受体调制剂；脂酰辅酶A结合蛋白)DnaJ(Hsp40)同系物；亚家族A；成员1包含DNAJ结构域双特异性酪氨酸-(Y)-磷酸化调节的激酶1B动力蛋白轻链2A动力蛋白；细胞质部分；轻链多肽E74样因子3(ets结构域转录因子；上皮细胞特异性)内皮细胞分化相关因子1未发育同系物增强子(果蝇)烯醇化酶1；(α)烯醇化酶1；(α)真核翻译延伸因子1α1真核翻译延伸因子1γ真核翻译延伸因子2真核翻译起始因子3；亚基3(γ；40kD)真核翻译起始因子3；亚基4(δ；44kD)真核翻译起始因子3；亚基6(48kD)真核翻译起始因子3；亚基7(ζ；66/67kD)真核翻译起始因子4A；同工型1真核翻译起始因子4A；同工型2真核翻译起始因子5A   12335.743019.1622535.4037921.6824071.9827729.1262541.0112491.0512324.9338211.9654080.9494492.6793781.1965515.6923593.60812539.976900.85736222.346863.5654023.8552870.0273009.0752755.4384273.9197716.2222091.8169023.244   122001900185011200763075701730293025206870416058002780568039507460429023200654023101930267015404030717021905240   9883.6883329.2812088.8089546.8962153.6386083.4082995.7681789.6622397.8965987.395365.9284332.1611455.9444090.5275175.1319955.0245016.69523485.9411607.613360.0732391.8693333.7282127.8743558.8386363.1692519.3225651.752   11482.482750.9742157.7839563.2414619.6117126.012422.5782402.3982414.4577023.5994534.2834875.6852673.7445094.8564241.0369983.7745403.44427648.748337.9013231.3252398.3943005.5772141.683954.3747083.992267.0156638.65   -3.20E-011.41E-01-2.80E-012.69E-01-9.19E-01-3.45E-012.38E-01-4.77E-014.46E-02-4.56E-013.95E-01-5.25E-02-1.38E+00-4.31E-015.26E-01-3.33E-01-4.60E-01-6.25E-017.58E-01-2.60E-01-2.63E-011.48E-01-3.73E-01-2.64E-01-2.78E-012.68E-01-6.75E-01   -1.27E-02-6.65E-01-4.55E-015.02E-019.07E-01-3.09E-02-5.54E-012.32E-011.17E-01-2.57E-012.63E-023.69E-01-4.42E-014.19E-021.38E-01-7.50E-01-6.85E-01-6.40E-01-6.91E-02-8.01E-01-5.70E-01-1.70E-01-8.38E-01-8.46E-02-1.05E-016.61E-02-7.84E-01   333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q9NQT4P02794P02792Q05472P20071P50395P48507P36969P09211P04406P04406P04406P43304P41250P04895P24522Q92847P04901P25388P06351P04792P11021P38646Q9UK76P09651Q9Y4J5P09429P49773   H05gh4C12ab6M10ab3B02ab4F08ab3J02ab4E12ab5D14ab5L10ab3A01cd8H12cd8P12cd8H01ab3F02ef7K17ef5B03ef6M24ab5B01ef1E20cd6G08ab6A16ef5H01ef1O19ab7J14ef1F12ab7I23ef1F10ab7M03ef6   外染色体成分Rrp46铁蛋白；重链多肽1铁蛋白；轻链多肽Finkel-Biskis-Reilly鼠肉瘤病毒(FBR-MuSV)遍在表达(fox驱动)；核糖休蛋白质S30FK506结合蛋白质1A(12kD)GDP解离抑制因子2谷氨酸-半胱氨酸连接酶；修饰子亚基谷胱甘肽过氧化物酶4(磷脂氢过氧化物酶)谷胱甘肽S转移酶TT甘油醛-3-磷酸脱氢酶甘油醛-3-磷酸脱氢酶甘油醛-3-磷酸脱氢酶甘油-3-磷酸脱氢酶2(线粒体)甘氨酰-tRNA合成酶GNAS复合座位生长停滞和DNA损伤可诱导；α生长激素促泌素受体鸟嘌呤核苷酸结合蛋白(G蛋白)；β多肽1鸟嘌呤核苷酸结合蛋白(G蛋白)；β多肽2样1H3组蛋白；家族3B(H3.3B)热休克27kD蛋白质1热休克70kD蛋白5(葡萄糖调节蛋白质；78kD)热休克70kD蛋白9B(mortalin-2)血液学和神经学表达的1不均一核内核糖核蛋白A1不均一核内核糖核蛋白H3(2H9)高迁移率组(非组蛋白染色体)蛋白1三联组氨酸核苷酸结合蛋白质1   2098.51435912.8144225.8610322.942741.3892287.713154.17733397.26392.33428809.3737562.2512053.53450.6344333.4397755.8582792.4292827.9025734.33722430.282448.26441952.143226.1832851.74326342.332522.2533825.9122534.2736025.978   25904870029600104001870158076.2486086703830060200149002340363092906130210076101530027703450016002180354001650237016607790   2304.4842075.2217849.29704.6421414.9692291.275937.3753108.0364067.78944655.6757135.4119061.623276.2646248.6049107.5583396.7362597.1235853.11219055.72042.86431970.864101.7422220.50941099.582524.0823770.4573502.0477379.267   2331.05642243.5930568.1310145.462009.2912051.412055.9143787.136378.19837260.6751621.5515342.73023.3924736.6328718.934105.1382508.4146398.8518939.852421.65836135.192976.5372417.79134286.742231.4133320.4872567.0937064.436   1.35E-012.28E-01-1.31E+00-8.91E-02-9.54E-012.24E-035.27E+00-1.28E-01-6.52E-016.32E-016.05E-016.61E-01-7.48E-025.28E-012.32E-012.83E-01-1.23E-012.96E-02-2.35E-01-2.61E-01-3.92E-013.46E-01-3.61E-016.42E-011.05E-03-2.11E-024.67E-012.92E-01   3.04E-014.41E-01-5.78E-011.19E-02-5.51E-01-5.38E-01-1.02E+005.15E-014.40E-014.11E-016.80E-013.07E-01-5.58E-01-2.56E-012.61E-011.13E+00-4.29E-014.08E-01-5.49E-011.80E-01-2.83E-01-1.01E+00-3.87E-014.27E-01-6.14E-01-6.94E-01-6.06E-013.70E-01   3333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q92769P17693P17483Q9UL99Q9GZT3Q9NWY5Q9UI30Q9BQB6Q9BWJ5Q9Y683Q16665O75353Q16270Q9Y287P56537P26006P05556Q01628Q12905Q13907P33947P00338P08865Q08380O14949Q15012   N05ab4F08ab7C15gh2C01cd8L18gh7O12gh2P08ef2P08gh5P18gh7N11ef2P01ef6G04ef6J15ab6A03gh2D16ab6D08ab6G01ef7C09gh7C10ab7A24ab7K03cd7D15ab7G21ef7D17ab7F17ef3F20ef4   组蛋白脱乙酰基酶2HLA-G组织相容性抗原；I类；G同源异形盒B4透明质酸氨基葡糖苷酶4假定蛋白质DC50假定蛋白质FLJ20533假定蛋白质HSPC152假定蛋白质IMAGE3455200假定蛋白质MGC3133假定蛋白质MGC8721低氧可诱导因子1；α亚基(碱性螺旋-环-螺旋转录因子)即早期反应3胰岛素样生长因子结合蛋白质7膜内在蛋白质2B整联蛋白β4结合蛋白质整联蛋白；α3(抗原CD49C；VLA-3受体的α3亚基)整联蛋白；β1(纤连蛋白受体；β多肽；抗原CD29包括MDF2；MSK12)干扰素诱导的跨膜蛋白质3(1-8U)白细胞介素增强子结合因子2；45kD异丙烯二磷酸δ异构酶KDEL(Lys-Asp-Glu-Leu)内质网蛋白质保持受体2乳酸脱氢酶A层粘连蛋白受体1(67kD；核糖体蛋白质SA)凝集素；结合半乳糖苷；可溶；3结合蛋白质低分子量泛醌结合蛋白质(9.5kD)溶酶体相关蛋白质跨膜4α   2454.3242048.0092892.4883623.4613343.9223104.4713000.2173599.5092074.0732425.4753544.7534564.4086185.6226908.9972594.3162669.7776743.42814426.623045.4842958.1391667.24644081.298548.2452294.4912942.5792815.002   222027803490205037505460406054102520273029604690218001050032702740539014800242016601250345006070285035504690   1789.5081844.1772902.692189.6564298.6766184.2274396.8628687.3072719.6712939.2531526.9353129.72118047.3410014.471568.7471339.7126511.5798827.9972596.9152475.3653924.99342150.039921.4093014.023637.4635453.634   2155.5752225.1063095.0042621.2863797.9434915.4193819.3135897.3372436.7672699.5452675.6684129.09815334.479139.9332476.0622249.0266216.31412669.242687.5382362.9332281.69240260.248180.6072719.7943377.3054319.567   -4.56E-01-1.51E-015.08E-03-7.27E-013.62E-019.94E-015.51E-011.27E+003.91E-012.77E-01-1.22E+00-5.44E-011.54E+005.36E-01-7.26E-01-9.95E-01-5.05E-02-7.09E-01-2.30E-01-2.57E-011.24E+00-6.46E-022.15E-013.94E-013.06E-019.54E-01   -1.43E-014.42E-012.71E-01-8.21E-011.66E-018.14E-014.37E-015.87E-012.79E-011.73E-01-2.62E-014.01E-021.82E+006.03E-013.32E-013.62E-02-3.22E-013.23E-02-3.32E-01-8.38E-01-4.12E-01-3.52E-01-4.93E-013.13E-012.71E-017.36E-01   33333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P14174P49006P30463P10321P10321P10321P13747Q95HC0P13640P80297P02795O14880Q9NYZ2P26038O15329P16475P19105Q9UK23O15239O00483O75438O95168O95298O43920Q13765   J05ef7M05ef6G10ab6A01cd2H12cd2P12cd2M24ab7P02gh6D13gh6D17gh6L04ab7E04ab7M22ef2K05ab7O12ef1J02gh1N03cd6D06ef1E22ab7J02ab7J04ab8J08ab8J12ab8J18ab8H09ab7   巨噬细胞游走抑制因子(糖基化抑制因子)巨噬细胞富含豆蔻酰化丙氨酸C激酶底物主要组织相容性复合物；I类；B主要组织相容性复合物；I类；C主要组织相容性复合物；I类；C主要组织相容性复合物；I类；C主要组织相容性复合物；I类；E主要组织相容性复合物；I类；F金属硫蛋白1G金属硫蛋白1X金属硫蛋白2A微粒体谷胱甘肽S-转移酶3线粒体溶质载体膜突蛋白粘蛋白6；胃肌球蛋白；轻链多肽6；碱性；平滑肌和非肌肉肌球蛋白；轻链多肽；调节型，非肌节(20kD)N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖胺糖苷酶NADH脱氢酶(泛醌)1α子复合物；1(7.5kD；MWFE)NADH脱氢酶(泛醌)1α子复合物；4(9kD；MLRQ)NADH脱氢酶(泛醌)1β子复合物；1(7kD；MNLL)NADH脱氢酶(泛醌)1β子复合物；4(15kD；B15)NADH脱氢酶(泛醌)1；子复合物未知；2(14.5kD；B14.5b)NADH脱氢酶(泛醌)Fe-S蛋白质5(15kD)(NADH-辅酶Q还原酶)初生多肽相关复合物α多肽   5544.7225857.3822701.7578949.0867187.90513121.352540.9115067.2946180.3764881.9826620.2355023.5422488.074260.515574.09348122.627920.8731884.5962859.7385214.2221628.0242297.7871909.3716241.1352800.535   6700104004890170002160016800279041404750531073307940285045805950452008150268054405540217032702840115003390   6763.7188986.3152255.92910196.8811111.5411725.682053.3513295.1152940.6835233.7498067.2744177.1652240.8243801.2986685.04748882.547228.4012511.2933719.5039086.6152842.6472253.8542888.2818014.1873897.956   6337.0628400.7253281.59212044.8913298.1913868.022460.5034168.8354624.8495142.9967340.2155712.0432527.4364212.4276068.26947407.027764.9942357.0874005.8946613.0462212.9322607.4232544.6798594.083363.371   2.87E-016.17E-01-2.60E-011.88E-016.28E-01-1.62E-01-3.07E-01-6.21E-01-1.07E+001.00E-012.85E-01-2.66E-01-1.51E-01-1.65E-012.62E-012.26E-02-1.32E-014.14E-013.79E-018.01E-018.04E-01-2.79E-025.97E-013.61E-014.77E-01   2.74E-018.22E-018.55E-019.25E-011.59E+003.53E-011.33E-01-2.90E-01-3.79E-011.22E-011.48E-016.60E-011.98E-011.03E-019.31E-02-8.99E-024.04E-025.05E-019.27E-018.70E-024.13E-015.09E-015.71E-018.85E-012.76E-01   3333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q15843Q9NX14Q9Y2R6Q15668O14597P15531P22392O00746O75534Q9H9A1Q9NPE3P54368Q9UH52Q15070Q9H230O60356P78337Q9C086Q15165P20962P23284Q06830P32119P30048Q13162P30044Q13492P08237   K13cd1C01gh3F18gh6H13cd6J21ef4E02ef5L12cd2D04ef7B01cd4C24gh6K15ef4G10ef1L23cd8A09cd1G14gh5M03cd8M22ab8P20gh7D06ef6N13ab8I17ab8E18ab8G04ef7N09ab2N07ab2P15cd7B13cd4P02ab7  神经前体细胞表达的；发育下调的8神经元蛋白质17.3NICE-3蛋白质尼曼-皮克病；C2型无功能性叶酸结合蛋白质非转移细胞1；其中表达的蛋白质(NM23A)非转移细胞2；其中表达的蛋白质(NM23B)非转移细胞4；其中表达的蛋白质NRAS相关基因细胞核受体辅阻遏物/HDAC3复合物亚基核仁蛋白质家族A；成员3(H/ACA小核仁RNPs)鸟氨酸脱羧酶抗酶蛋白1过表达的乳腺肿瘤蛋白质氧化酶(细胞色素c)装配1样p53诱导的蛋白质PIGPC1p8蛋白质(转移候选物1)配对样同源结构域转录因子1PAP-1结合蛋白质对氧磷酶2旁胸腺素肽酰脯氨酰异构酶B(亲环蛋白B)peroxiredoxin 1peroxiredoxin 2peroxiredoxin 3peroxiredoxin 4peroxiredoxin 5磷脂酰肌醇结合网格蛋白装配蛋白质果糖磷酸激酶；肌肉   3449.4843476.8121763.9741516.5922917.2936653.5154827.4942211.0583478.6575951.7153543.2397212.0682335.5272161.5291823.5541774.94215428.962992.21325.9722345.8695298.8392973.8623141.7182420.9362744.7072205.142688.9172790.708   47103150225036402170694056802270351032907130688023202500333019401330036103740233058602450333020102080382026901980   4139.565077.8342329.5212828.2553004.0127836.8974836.5964300.6042737.4252990.0833639.2057782.3391884.2641436.4631443.9142740.79214490.635014.2152122.1193489.6168890.432056.1122921.4711671.7963645.7181714.0411861.5082829.743   4098.7473902.82113.5112662.8452697.1087143.3495114.6642927.2233241.2694076.5444771.6567292.8182181.4822031.7962199.3672150.63114411.943872.9692394.7172722.3176683.1662493.753130.8352035.2182822.1392581.242414.9982533.875   2.63E-015.46E-014.01E-018.99E-014.23E-022.36E-012.72E-039.60E-01-3.46E-01-9.93E-013.86E-021.10E-01-3.10E-01-5.90E-01-3.37E-016.27E-01-9.05E-027.45E-016.78E-015.73E-017.47E-01-5.32E-01-1.05E-01-5.34E-014.10E-01-3.63E-01-5.31E-012.00E-02   4.48E-01-1.41E-013.49E-011.26E+00-4.27E-016.07E-022.35E-013.80E-021.20E-02-8.56E-011.01E+00-6.72E-02-6.73E-032.08E-018.69E-011.25E-01-2.12E-012.72E-011.49E+00-8.88E-031.45E-01-2.79E-018.37E-02-2.66E-01-4.03E-017.94E-013.03E-03-4.94E-01   3333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P00558P18669Q14801O14832P53801Q9HB21Q15365P52433P52436Q03052P40425Q99471Q9UHZ2P07737Q92740P07478Q9UL46P25786P20618P49720P28070Q99436   P06ab7K14ab8B01cd8A04cd1L01ef1E19gh5O09cd1B17ab8L16gh1B19ab8K20gh5G08ab8K06ab8E21ef8A21cd1E03gh1N02cd2N09ab8L09ef7J17ab8J21ab8J23ab8L03ab8   磷酸甘油酸激酶1磷酸甘油酸变旋酶1(脑)星形细胞富含的磷蛋白15植烷酰辅酶A羟化酶(雷夫叙姆病)脑垂体肿瘤转化1互作蛋白质包含普列克底物蛋白同系物结构域；家族A(磷酸肌醇结合特异性)成员1多聚(rC)结合蛋白质1聚合酶(RNA)II(DNA指导的)多肽G聚合酶(RNA)II(DNA指导的)多肽L(7.6kD)POU结构域；3类；转录因子1PP1201蛋白质前B细胞白血病转录因子2prefoldin 5PRO1073蛋白质抑制蛋白1prosaposin (各种戈谢病和各种异染性脑白质营养不良)蛋白酶；丝氨酸；2(胰蛋白酶2)蛋白酶体(前体；macropain)活化子亚基2(PA28β)蛋白酶体(前体；macropain)亚基；α型；1蛋白酶体(前体；macropain)亚基；β型；1蛋白酶体(前体；macropain)亚基；β型；3蛋白酶体(前体；macropain)亚基；β型；4蛋白酶体(前体；macropain)亚基；β型；7   5186.3461847.46323286.567333.1044385.3082318.084617.6352157.3532161.3983321.2067127.2932817.1911827.7771872.20829650.384235.23277359.273682.1532270.0792835.6531714.7672193.1384179.694   51302730174007780533030703130378026002650665026502160314048900537042600455025703590210017603450   6341.682859.44619729.368341.9174172.1372907.3813156.6443657.7632709.4952251.6772688.6363413.812837.3341690.10135394.84268.45951746.682712.1722265.7632820.9162435.4262224.3253072.098   5552.7362477.7520128.937819.0364627.8812766.3593635.4313198.2852489.3432740.9135487.0852958.9762275.0382234.20937970.064622.89857240.673648.9952369.4373082.0032081.9912058.2123566.368   2.90E-016.30E-01-2.39E-011.86E-01-7.19E-023.27E-01-5.49E-017.62E-013.26E-01-5.61E-01-1.41E+002.77E-016.34E-01-1.48E-012.55E-011.13E-02-5.80E-01-4.41E-01-2.75E-03-7.52E-035.06E-012.04E-02-4.44E-01   -1.57E-025.61E-01-4.23E-018.57E-022.80E-014.07E-01-5.60E-018.09E-012.65E-01-3.26E-01-1.01E-01-9.05E-022.41E-017.46E-017.21E-013.41E-01-8.60E-013.06E-011.80E-013.40E-012.89E-01-3.20E-01-2.78E-01   33333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高P
  P08129O15355P30153Q15249Q9NQ11P41567Q15181P14786P57735P54725P54727O00538P06749P08134P15154Q15347O95197P09455P52565P27635P53025P39026P30050P40429P50914P39030P18621Q07020Q02543   G01ef6D07ab8A06ef3H13ef5G03gh7N06cd5L18gh1M24ab8G12gh4E21cd1M10ef6P16cd5C21gh1B16ab2P06gh8C01ef6B20cd6A06cd6F12ab8K13ef6N19cd2G22cd1D07cd1D09cd1A01ef1B18cd4C13cd3D19cd1D13cd1C15gh1   蛋白质磷酸酶1；催化亚基；α同工型蛋白质磷酸酶1G(从前2C)；镁依赖性；γ同工型蛋白质磷酸酶2(从前2A)；调节亚基A(PR 65)；α同工型前胸腺素；α(基因序列28)推断的ATP酶推断的翻译起始因子焦磷酸酶(无机)丙酮酸激酶；肌肉RAB25；成员RAS癌基因家族RAD23同系物A(酿酒酵母)RAD23同系物B(酿酒酵母)RAS脒基释放蛋白质2(钙和DAG调节型)ras同系物基因家族；成员Aras同系物基因家族；成员Cras样蛋白质VTS58635ras相关C3肉毒杆菌毒素底物1(rho家族；GTP结合小蛋白质Rac2)Ras相关GTP结合蛋白质网胃3视黄醇结合蛋白1；细胞的Rho GDP解离抑制因子(GDI)α核糖体蛋白质L10核糖体蛋白质L10a核糖体蛋白质L11核糖体蛋白质L12核糖体蛋白质L13a核糖体蛋白质L14核糖体蛋白质L15核糖体蛋白质L17核糖体蛋白质L18核糖体蛋白质L18a   2543.0895896.4083858.56711382.442774.7247487.8724914.8976305.2223343.6282533.364038.8642418.6882136.7084404.5675451.54210849.131728.9633712.7562211.123166.0413406.2919374.7314172.2938376.6923800.518507.368407.5328779.14112168.4324976.59   2200420041001450024606600435080604890179054102310194044906580972023803420448032007100151006760245002220014600810084401020027200   2276.4623717.852765.0119974.5872271.5938909.5452667.6059000.5041366.3791753.1134983.211906.1993003.8412930.2369066.79810044.192623.4183833.4112383.2743141.43411103.6919939.2610346.9238669.3428159.3716108.1810809.1210004.7815619.1728170.19   2339.7974605.0643572.8911954.682501.1627666.7793978.5377787.9223198.6992026.1264809.1322210.1912358.6683943.0297033.47910202.942244.9783654.063023.273169.00910536.2518124.9110427.0733860.1324735.8516402.149104.5899074.16812658.4526796.74   -1.60E-01-6.65E-01-4.81E-01-1.90E-01-2.89E-012.51E-01-8.82E-015.13E-01-1.29E+00-5.31E-013.03E-01-3.44E-014.91E-01-5.88E-017.34E-01-1.11E-016.02E-014.61E-021.08E-01-1.13E-02-2.72E-014.14E-02-4.54E-011.10E-022.43E-01-2.00E-013.62E-011.89E-013.60E-011.74E-01   -2.09E-01-4.89E-018.58E-023.50E-01-1.75E-01-1.81E-01-1.75E-013.54E-015.47E-01-5.00E-014.20E-01-6.90E-02-1.43E-012.91E-022.72E-01-1.59E-014.63E-01-1.20E-011.02E+001.52E-02-9.17E-01-3.63E-01-1.07E+00-6.45E-01-9.73E-02-3.43E-01-5.43E-02-5.71E-02-2.56E-011.25E-01   333333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
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  P39027P17008P08708P25232P17075P35265P39028P16632P25111P02383P42677P14798P25112P30054P23396P49241P12750P22090P46782P10660P23821P09058P46781P46781P46781P05387P05388P05386Q9Y254Q9NWJ8P08206   H23cd1J01cd1J03cd1A17gh2J07cd1D24ef7J09cd1J11cd1J13cd1C01cd3G01cd3B18cd1J15cd1J17cd1H03cd1O16ef5A21cd3A23cd3H05cd1H07cd1H09cd1H11cd1A01cd5H12cd5P12cd5H01cd1F21cd1F23cd1C08ef3A23gh3D06cd1  核糖体蛋白质S15a核糖体蛋白质S16核糖体蛋白质S17核糖体蛋白质S18核糖体蛋白质S20核糖体蛋白质S21核糖体蛋白质S23核糖体蛋白质S24核糖体蛋白质S25核糖体蛋白质S26核糖体蛋白质S27(metallopanstimulin 1)核糖体蛋白质S27a核糖体蛋白质S28核糖体蛋白质S29核糖体蛋白质S3核糖体蛋白质S3A核糖体蛋白质S4；X连锁核糖体蛋白质S4；Y连锁核糖体蛋白质S5核糖体蛋白质S6核糖体蛋白质S7核糖体蛋白质S8核糖体蛋白质S9核糖体蛋白质S9核糖体蛋白质S9核糖体蛋白质；大P2核糖体蛋白质；大；P0核糖体蛋白质；大；P1ring盒1roundabout同系物4；magicroundabout(果蝇)S100钙结合蛋白质A10(膜联蛋白II配基；依钙蛋白I；轻链多肽(p11))   16787.126604.513979.2512558.1821944.1314046.712228.9612913.376274.15926138.2617556.943284.55130384.2418454.555913.6827154.08819821.562629.69715421.0846408.1818906.9415941.26215.5628827.4169059.52316611.1417127.412228.2982597.5781969.60238485.73   1510015700799012600199009470109001310056303090012800318032000209002830620016200233011000261001620012300393097101790127001240018804260394049800   21854.0124481.5515360.8820093.0731381.439023.67814550.1712135.495123.74719440.220383.132757.25228529.2125539.275523.5618592.24821778.052779.18417355.5440579.4614326.8820997.595714.84315295.985725.08217775.7219746.883134.5293365.1652093.27931745.47   17912.9222257.312443.0915089.724400.9810847.4312545.612699.845677.33725499.9216927.43073.1730318.4721630.24754.2187316.66719282.52580.92414598.9637695.2416494.2416406.165285.19311278.365525.88315695.1416430.542413.783408.8922666.6640017.88   3.81E-01-1.20E-011.36E-016.78E-015.16E-01-6.38E-012.51E-01-8.96E-02-2.92E-01-4.27E-012.15E-01-2.52E-01-9.09E-024.69E-01-9.85E-022.64E-011.36E-017.98E-021.70E-01-1.94E-01-4.00E-013.97E-01-1.21E-017.93E-01-6.62E-019.78E-022.05E-014.92E-013.74E-018.79E-02-2.78E-01   -1.53E-01-7.62E-01-8.07E-016.84E-03-1.43E-01-5.69E-01-1.72E-011.53E-02-1.55E-012.42E-01-4.51E-01-4.77E-027.66E-021.79E-01-1.07E+00-2.06E-01-2.87E-01-1.72E-01-4.85E-01-8.30E-01-2.19E-01-3.76E-01-6.63E-011.38E-01-2.34E+00-3.87E-01-4.64E-01-2.46E-017.15E-019.99E-013.72E-01   3333333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P31949P06703P55735P38384Q9NZJ3O15532Q13501P35237P05121Q00587Q9H299P37108P49458P43308P51571O00422O75918P13500Q15356P14648P12236Q00325P32745   E09cd3P17gh6J04ef4I06ef3H06ef2H16cd1J23cd4L18ab8P05ef7C14cd7P16gh7E21cd2E19cd2G15cd2O15gh1M17cd6J10cd5C15cd3A09cd2A13cd2G01ef1K22ab8N01cd1 S100钙结合蛋白质A11(calgizzarin)S100钙结合蛋白质A6(钙周期蛋白)SEC13样1(酿酒酵母)Sec61 Y含硒蛋白质T含硒蛋白质W；1sequestosome 1丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade B(卵清蛋白)；成员6丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade E(微管连接蛋白；纤溶酶原激活物抑制剂1型)；成员1血清组分蛋白质SH3结构域结合富含谷氨酸蛋白质样3信号识别颗粒14kD(同源Alu RNA结合蛋白质)信号识别颗粒9kD信号序列受体；β(易位子相关蛋白质β)信号序列受体；δ(易位子相关蛋白质δ)sin3相关多肽；18kD富含EDRK的小因子2可诱导的小细胞因子A2(单核细胞趋化蛋白1)核内小分子核糖核蛋白多肽F核内小分子核糖核蛋白多肽N溶质载体家族25(线粒体载体；腺嘌呤核苷酸转位分子)；成员6溶质载体家族25(线粒体载体；磷酸载体)；成员3生长抑素受体3   8890.5943403.1461695.1525653.9552923.8132678.8433214.3954203.0744454.562480.69814473.624326.271874.9674209.1472062.1132502.795927.59517077.972743.428899.62427384.0665074.3084102.668   111004070199078202440297031708180728026601710035600264046102330261070103810021502800476037504170   5408.2692088.4782362.5417254.4231325.4913918.441164.172936.729179.8632044.60813798.0224319.593141.4225876.4512654.9682079.2957926.0598786.3232819.8552362.5976176.0343779.5774748.989   8466.7143188.7532016.0626908.4322230.0913189.6422517.5435105.4776972.2842393.4615134.7428082.562551.9284898.5812349.292396.0026955.24521330.262570.9012021.4296107.9954200.6264340.964   -7.17E-01-7.04E-014.79E-013.60E-01-1.14E+005.49E-01-1.47E+00-5.17E-011.04E+00-2.79E-01-6.90E-02-3.96E-047.45E-014.81E-013.65E-01-2.67E-014.19E-01-9.59E-013.96E-021.39E+00-2.58E-01-4.25E-012.11E-01   3.20E-012.60E-012.32E-014.67E-01-2.60E-011.50E-01-1.82E-029.60E-017.09E-019.80E-022.43E-015.49E-014.93E-011.31E-011.77E-015.83E-022.42E-011.16E+00-3.52E-011.64E+00-6.32E-01-4.37E-012.39E-02   33333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  P30626Q01826P21673P34991P23246P35716P35713Q06945P00441P50502Q9Y5Y6P17600O43759Q12962Q15763P10599P13472P01253Q01085Q15370O43680P21980P29401O60739   E13cd2F18ef6D12cd1G05cd3B0gcd2C07cd2E10ef4C05cd2G20ef7I18cd2P20gh1J06cd2G11cd5P19cd2B20cd2B23cd4O02ef7L12gh1C02cd2J12cd2O11cd2O16cd2N15cd1O01cd6   抗药蛋白特异性富含AT序列结合蛋白质1(结合到核基质/支架相关DNA)亚精胺/精胺N1乙酰转移酶S期激酶相关蛋白质1A(p19A)剪接因子富含脯氨酸/谷氨酰胺(多聚嘧啶串结合蛋白质相关)SRY(性别决定区Y)盒11SRY(性别决定区Y)盒18SRY(性别决定区Y)盒4超氧化物歧化酶1；可溶(肌萎缩性侧索硬化1(成人))抑制致瘤性13(结肠癌)(Hsp70互作蛋白质)抑制致瘤性14(结肠癌；matriptase；epithin)突触蛋白I突触孔蛋白1TAF10RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；30kDt复合物相关睾丸表达1样1硫氧还蛋白胸腺素；β10胸腺素；β4；X染色体TIA1细胞毒颗粒体相关RNA结合蛋白质样1转录延伸因子B(SIII)；多肽2(18kD；elongin B)转录因子21转氨酶2(C多肽；蛋白谷氨酰胺γ-谷氨酰转移酶)转酮醇酶(韦尼克-科尔萨科夫综合征)翻译因子sui1同系物   1895.59226449.328349.8823072.6012694.6295019.9882575.7912299.4744439.3422307.5992358.281969.15714516.65937.2552022.99711525.1646982.9123145.542250.4562616.5951789.2953131.0793258.5752671.935   279041300165002990246048603100221049302530270022201070050802890119007430026000177039801790349020403400   2280.29724225.616013.6592396.5063348.4232125.0892024.3861636.0673239.1952358.1171494.8562010.90810060.613962.3232885.0176440.3754263.4816231.512917.3423919.3273044.1181857.5962715.2063868.727   2323.14930645.0910275.932820.6432834.0564001.2412565.9982049.2144202.9542400.0852183.0412067.41711775.534992.5282600.4599965.77758508.6821783.422312.3313505.3842209.0142827.7742671.5043315.099   2.67E-01-1.27E-01-4.74E-01-3.59E-013.13E-01-1.24E+00-3.48E-01-4.91E-01-4.55E-013.12E-02-6.58E-013.03E-02-5.29E-01-5.83E-015.12E-01-8.40E-012.08E-01-5.12E-013.74E-015.83E-017.67E-01-7.53E-01-2.63E-015.34E-01   5.59E-016.42E-019.80E-01-3.80E-02-1.32E-01-4.71E-022.66E-01-5.59E-021.51E-011.35E-011.93E-011.74E-01-4.33E-01-2.26E-015.16E-015.00E-026.61E-011.66E-01-3.47E-016.05E-013.49E-031.58E-01-6.75E-013.50E-01   333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q9NS69P00938P07226P04687P04687Q13509P04350O75347O75509P13693P14625P42655Q04917P29312P29312O14957P14793P02248O76069Q9BZL1P08670P45880Q9Y277P17861O43670Q07352Q15942   I02gh7M24cd1G10cd2F09cd4A01cd1E04cd6F01gh6O08cd2L10ef3G16cd2G24cd2K04cd4G06cd3A01cd4P12cd4G17cd7D01cd4D22gh1B12cd4B17gh7C24cd3C18cd3C04cd4O15cd4M04cd3N21ef6M10cd3   线粒体外膜易位酶22同系物(酵母)磷酸丙糖异构酶1原肌球蛋白4微管蛋白；α3微管蛋白；α；遍在的微管蛋白；β；4微管蛋白；β；5微管蛋白特异性分子伴侣a肿瘤坏死因子受体超家族；成员21肿瘤蛋白质；翻译控制1肿瘤排斥抗原(gp96)1酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；ε多肽酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；η多肽酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；ζ多肽酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；ζ多肽泛醌-细胞色素C还原酶(6.4kD)亚基泛素A-52残基核糖体蛋白质融合产物1泛素B泛素缀合酶E2M(UBC12同系物；酵母)泛素样5波形蛋白电压依从性阴离子通道2电压依从性阴离子通道3X盒结合蛋白质1锌指蛋白207锌指蛋白36；C3H型样1斑联蛋白   2988.4235701.292636.25620220.0315258.812338.8777573.7653000.0652245.33839878.182185.1876584.5658621.3225873.2824562.9642728.7653536.2252753.9422001.2624339.4745940.8767005.5371863.4243398.4553338.1176097.3842570.21   24505820230014500784029904430390048906080020605730815046701140399017304430198091008720728022101600317057502070   3754.9148345.7383755.88222303.8822478.651853.2733448.4553275.6291881.23148468.254905.3425558.9744562.3662279.1481520.23332.4223258.4394152.2352223.5745279.83517783.44758.1792573.8852040.2243176.6314958.2242519.748   3062.8096622.2432897.50918992.3115193.762394.895149.4983390.7193007.07849731.113049.3465956.7137111.9324275.5062406.4973351.452840.7323779.3522068.6466239.51310813.946347.0142216.752347.3333226.6435601.5182387.987   3.29E-015.50E-015.11E-011.42E-015.59E-01-3.36E-01-1.14E+001.27E-01-2.55E-012.81E-011.17E+00-2.44E-01-9.18E-01-1.37E+00-1.59E+002.88E-01-1.18E-015.92E-011.52E-012.83E-011.58E+00-5.58E-014.66E-01-7.36E-01-7.15E-02-2.98E-01-2.86E-02   -2.89E-012.97E-02-1.97E-01-4.84E-01-9.60E-013.56E-01-7.75E-013.77E-011.12E+006.10E-01-8.69E-02-2.01E-01-8.07E-02-3.29E-01-2.01E+005.49E-01-1.03E+006.86E-01-1.46E-021.07E+005.53E-015.49E-022.48E-01-1.08E+00-7.67E-02-8.49E-02-3.09E-01   333333333333333333333333333   恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高恒高
  Q16659O75324Q9BYP8P55291P49768P55107P17082P23634P78347P09912Q9H2F5O14811O60942Q9Y5Y3P11908Q92851Q9BQE5P55327P28332O95861Q9NXJ5Q15642O94997O95453Q9H9C5P10451P53992Q9NQW1Q01449Q9NX46   B17ef5B05cd3E16gh8J01ab4L14ab7G10ab5P18cd7N08ab2J20ab5F08ef7F13gh7M06cd7A17cd4M18cd7H15ab8P18ab3M03gh7D05cd2K03ab2E02cd6A10gh2K09gh1O09cd7G02ab8F01gh7B13cd1B03cd5F22gh6A17gh5K12gh2  促分裂原活化蛋白激酶6stannin角蛋白相关蛋白质17.1钙粘蛋白15；M-钙粘蛋白(肌管)早老素1(阿尔茨海默病3)生长分化因子10相关RAS病毒(r-ras)癌基因同系物2ATP酶；Ca++转运；质膜4普通转录因子II；i干扰素；α可诱导蛋白质(克隆IFI-6-16)polycomb 1增强子程序性细胞死亡10RNA鸟苷酸转移酶和5′-磷酸酶G蛋白偶联受体45磷酸核糖焦磷酸合成酶2半胱天冬酶10；凋亡相关半胱氨酸蛋白酶载脂蛋白L；2肿瘤蛋白质D52乙醇脱氢酶6(V类)3′(2′)；5′-二磷酸核苷酸酶1假定蛋白质FLJ20208甲状腺激素受体互作子10黄体酮诱导的蜕膜蛋白质多聚(A)特异性核糖核酸酶(脱腺苷化核酸酶)KIAA1453蛋白质分泌磷蛋白1(骨桥蛋白；骨唾液蛋白I；早期T淋巴细胞活化1)SEC24相关基因家族；成员C(酿酒酵母)分泌途径组分Sec31B-1肌球蛋白轻链2a假定蛋白质FLJ20446   144.6425131.7242176.4958158.7215127.9653114.7206433.219179.3836151.6834183.6419127.3938152.3457176.7836174.3335166.1373135.919109.8196136.2596142.4055128.1251122.4219120.9158174.3087139.9344135.8299190.4604134.307111.3643179.1031109.5374   141172174128124168176276103105011513297.116117410714811297.711615114214010512676.7105158170159   100.0111100.0655100.1011100.3297100.3504100.6326100.8465100.9041100.9514101.0749101.3763101.596101.6765101.8478101.9334101.9435102.0533102.1111102.1575102.1715102.3038102.3082102.3137102.3217102.4347102.5193102.5437102.6234103.0725103.1083   128.6073134.7009150.0893128.8583117.5823127.9343236.7776185.4081118.6963444.3716114.5773128.8019125.1735145.8365147.2722115.0308119.8218116.9522114.0924115.4153125.322121.6641138.8592115.7147121.5247123.2388113.9998123.8833150.5611123.8664   -5.32E-01-3.97E-01-8.18E-01-6.62E-01-3.51E-01-1.89E-01-2.10E+00-8.30E-01-5.87E-01-8.61E-01-3.30E-01-5.85E-01-7.98E-01-7.75E-01-7.05E-01-4.15E-01-1.06E-01-4.16E-01-4.79E-01-3.27E-01-2.59E-01-2.41E-01-7.69E-01-4.52E-01-4.07E-01-8.94E-01-3.89E-01-1.18E-01-7.97E-01-8.73E-02   -3.51E-023.88E-01-2.33E-02-3.16E-01-4.04E-025.54E-01-1.30E+006.21E-01-5.52E-012.51E+00-1.48E-01-2.02E-01-8.65E-01-1.12E-016.46E-02-3.42E-014.26E-01-2.77E-01-5.43E-01-1.44E-013.05E-012.30E-01-3.17E-01-4.16E-01-1.05E-01-1.31E+00-3.53E-015.02E-01-7.94E-025.37E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P53609Q15029P50458P33764Q9P289P52429P54578Q13219O60547P23297Q9H5J8Q14493Q9NZU0P80370Q9NYV4P09016Q13873O14878P52848Q14848O00204P35610Q04760P51690P26012Q14978   A23cd1J16cd4O23cd5B24cd1G03ef3P17cd3H17cd5E24ab8M12ab5I17ef6M01gh6I08cd4O16cd8B01ef7C23ef3C23ef5A16ab3B22ef4J01ab6A05cd5O04cd2E13gh1L03ab5H06ab2C11ef7K11cd5   蛋白质香叶基香叶基转移酶I；β亚基U5 snRNP特异性蛋白质；116kDLIM同源异形盒蛋白质2S100钙结合蛋白质A3Mst3和SOK1相关激酶二酰基甘油激酶；ε(64kD)泛素特异性蛋白酶14(tRNA鸟嘌呤糖基转移酶)妊娠相关血浆蛋白AGDP-甘露糖4；6-脱水酶S100钙结合蛋白质A1假定蛋白质MGC5306茎环(组蛋白)结合蛋白质纤连蛋白富含亮氨酸跨膜蛋白质3δ样1同系物(果蝇)CDC2-相关蛋白质激酶7同源异形盒D4骨形态发生蛋白受体；II型(丝氨酸/苏氨酸激酶)肌苷三磷酸酶(三磷酸核苷焦磷酸酶)N-脱乙酰基酶/N-磺基转移酶(葡糖胺酰类肝素)1TNF受体相关因子4磺基转移酶家族；细胞溶质部分；2B；成员1固醇O-酰基转移酶(脂酰辅酶A：胆固醇酰基转移酶)1醛酮变位酶I芳香基硫酸酯酶E(斑点状软骨发育异常1)整联蛋白；β8核仁和螺旋小体磷蛋白1   140.0296119.3284145.905150.5991133.5225128.7238160.7495112.9052147.2805145.2558216.091126.7755284.9107160.1421128.5947173.2254155.8113124.8814166.2411124.2461185.8106143.8417132.6871177.023110.7396117.0048   12812612020411612310815410812691.71552688010719286.812084.41361178810776.2170131   103.1248103.1503103.1971103.3783103.4345103.5015103.6864103.7948103.8004103.9033104.0432104.1318104.3033104.328104.3521104.3556104.4206104.4238104.4555104.4604104.4824104.5518104.5782104.5865104.6296104.685   123.8135115.9932122.9669152.5858117.7841118.2956124.2132123.4254119.8044124.9008137.2762128.4702219.1816114.8185113.4542156.5829115.6624116.398118.3793121.4689135.653112.1404114.7132119.2772128.4899117.4911   -4.41E-01-2.10E-01-5.00E-01-5.43E-01-3.68E-01-3.15E-01-6.33E-01-1.21E-01-5.05E-01-4.83E-01-1.05E+00-2.84E-01-1.45E+00-6.18E-01-3.01E-01-7.31E-01-5.77E-01-2.58E-01-6.70E-01-2.50E-01-8.31E-01-4.60E-01-3.43E-01-7.59E-01-8.19E-02-1.61E-01   -1.26E-017.28E-02-2.84E-014.36E-01-1.98E-01-6.96E-02-5.71E-014.44E-01-4.43E-01-2.10E-01-1.24E+002.85E-01-8.65E-02-1.00E+00-2.60E-011.50E-01-8.45E-01-5.89E-02-9.77E-011.27E-01-6.71E-01-7.08E-01-3.12E-01-1.22E+006.19E-011.61E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O00764Q9Y6Q5O95350P49748P08100Q15477O43520Q13039O15291Q9NR71O60884Q9BYE0Q9Y272Q9BUR5O60859Q9GZU1P19878Q13277P32456Q9H4M9Q9BTX7Q9NVN2Q99758   D16cd3P13cd5G04cd5C13ab2O24cd1F24cd2I17cd1P02ef4L12cd1L23gh4H10cd4J17gh8L01ef2M13gh6A13cd7A20gh4B15ab6K12cd2B04gh8N18ab4E01cd7O19gh6M02gh3A17ab2   吡哆醛(吡哆醇；维生素B6)激酶接头相关蛋白质复合物1；μ2亚基Homer；神经元即早期基因；3脂酰辅酶A脱氢酶；极长链视紫红质(视蛋白2；视杆细胞色素)(视网膜色素变性4；常染色体显性)superkiller viralicidic活性2样(酿酒酵母)ATP酶；I类；8B型；成员1ATP结合盒；亚家族A(ABC1)；成员2溶质载体家族7(阳离子氨基酸转运蛋白；γ+系统)；成员2线粒体神经酰胺酶DnaJ(Hsp40)同系物；亚家族A；成员2split 7的毛状及增强子(果蝇)RAS；地塞米松诱导的1假定蛋白质MGC4825神经病变目标酯酶mucolipin 1嗜中性粒细胞胞质因子2(65kD；慢性肉芽肿病；常染色体2)突触融合蛋白3A保留的鸟苷酸结合蛋白2；干扰素可诱导包含EH结构域的1染色体20开放阅读框121溶质载体家族4(阴离子交换剂)；成员1；衔接蛋白ATP结合盒；亚家族A(ABC1)；成员3   160.2678149.3929137.2833121.151125.3282102.5551199.1157175.7841276.3689108.9644221.9835128.0255101.205178.2636123.970785.32301310.5103118.5375130.849109.3786149.0051115.9099123.8178238.456   14010712614111618691.580.5176152239108166239117243515185124142151157114145   104.6915104.7705104.7829104.7897104.8101104.8138104.8252104.8585104.904104.9361104.9441104.9542104.9825105.0137105.029105.1039105.1041105.2511105.2594105.2611105.3893105.4128105.466105.5504   135.073120.3004122.6314122.4441115.4338131.0636131.8072120.383185.7368122.091188.5763113.8134124.0354140.65115.3513144.4516310.3051136.1937120.0361118.8515134.9992126.203114.476163.1362   -6.14E-01-5.12E-01-3.90E-01-2.09E-01-2.58E-013.14E-02-9.26E-01-7.45E-01-1.40E+00-5.43E-02-1.08E+00-2.87E-015.29E-024.24E-01-2.39E-013.01E-01-1.56E+00-1.72E-01-3.14E-01-5.54E-02-5.00E-01-1.37E-01-2.31E-01-1.18E+00   -1.92E-01-4.85E-01-1.26E-012.23E-01-1.10E-018.58E-01-1.12E+00-1.13E+00-6.52E-014.84E-011.05E-01-2.39E-017.13E-011.61E+00-8.28E-021.51E+007.31E-016.41E-01-7.76E-023.76E-011.54E-024.40E-01-1.17E-01-7.14E-01   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P43694Q13825Q92550Q9UJS0Q99611P17275Q13477Q14692P49908P54803P50991P35548P11309O75570Q9NY61Q9BTY8Q9NWS2O00180O15382Q9Y2Z1Q9Y315Q9Y592Q9NYT0Q9Y343Q9BVI4P30622Q08345P33176P55273   B06ef6C07ab3L23ef3C12ef3O05ef3F08ab6B09cd4D09gh1D13cd2M24ab3H09cd6K11ab7M14ab8A03cd5O01ef3D01gh7F09gh2H06ab6I05ab3D05ef2E18ef2P20ef1D20ef3M10ef4G09gh6B20cd1F08ef5C16ab7D14ab4   GATA结合蛋白质4AU RNA结合蛋白质/烯脂酰辅酶A水合酶环指蛋白10溶质载体家族25；成员13(柠檬素)硒基磷酸合成酶2jun B原癌基因粘膜血管定居因子细胞粘附分子1KIAA0187基因产物含硒蛋白质P；血浆；1半乳糖神经酰胺酶(克拉伯病)包含伴侣蛋白的TCP1；亚基4(δ)msh同源异形盒同系物2(果蝇)pim-1癌基因线粒体翻译释放因子凋亡对抗转录因子假定蛋白质MGC4342假定蛋白质FLJ20640钾通道；亚家族K；成员1(TWIK-1)支链转氨酶2；线粒体CGI-01蛋白质CGI-26蛋白质NY-REN-58抗原普列克底物蛋白2(小鼠)同系物SBBI31蛋白质假定蛋白质MGC3162网状内皮系统刺激素(里-施细胞表达的中间丝相关蛋白质)discoidin结构域受体家族；成员1驱动蛋白家族成员5B细胞周期蛋白依赖性蛋白激酶抑制剂2D(p19；抑制CDK4)   107.7539123.4494197.4603119.1806168.8742135.9478127.8352114.5267140.6083130.3854161.4396182.4309136.3951128.9238120.3605139.5304183.0823129.4915136.8391156.4563135.7793118.6541114.999123.0625140.5988116.8074266.6468123.567999.64375   16114011213912894.91101311041051481249911812492.914012295.5196111121153120123136264113174   105.5891105.6272105.7052105.8216105.8955105.9141105.9239105.9487105.9794105.9866106.0337106.057106.0757106.1208106.1404106.2168106.2384106.2703106.3058106.3369106.6662106.7049106.7508106.8362106.8523107.0013107.136107.2314107.4234   124.6996123.0884138.2365121.1782134.292112.2701114.7415117.1898116.7316113.8221138.5613137.5011113.8227117.597116.8527112.876143.0354119.3824112.8868153.067117.8557115.3792124.8364116.6438123.6298119.7985212.6497114.5075126.8971   -2.93E-02-2.25E-01-9.02E-01-1.72E-01-6.73E-01-3.60E-01-2.71E-01-1.12E-01-4.08E-01-2.99E-01-6.06E-01-7.83E-01-3.63E-01-2.81E-01-1.81E-01-3.94E-01-7.85E-01-2.85E-01-3.64E-01-5.57E-01-3.48E-01-1.53E-01-1.07E-01-2.04E-01-3.96E-01-1.27E-01-1.32E+00-2.05E-011.08E-01   5.77E-011.83E-01-8.24E-012.17E-01-3.99E-01-5.18E-01-2.11E-011.95E-01-4.41E-01-3.11E-01-1.23E-01-5.57E-01-4.62E-01-1.31E-014.36E-02-5.87E-01-3.89E-01-8.14E-02-5.19E-013.28E-01-2.89E-012.56E-024.10E-01-3.60E-02-1.88E-012.15E-01-1.35E-02-1.33E-018.01E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NW92Q9NZC3P15172P27144O60508Q14012P98179Q13223P55198P46459P34969Q14667Q92830O43252Q9NS93O60616P02261Q14701Q9P025P06702Q9Y5Q9P19075O60905Q13322Q9UQ09   E10gh3K03ef3M19ab7A06ab2A06ef2B08cd3G12cd1E10ab5N09ab7G02ef1I21ef1K02gh1J14cd8P14cd2J01cd5G09ef3E20ab6D19cd4F18ef7A04ef8O12ef7P05cd7O20cd2B16cd4F24ef5L01gh1   假定蛋白质FLJ10209RGS16的膜互作蛋白质肌性因子3腺苷酸激酶3前mRNA剪接因子17依赖于钙-钙调蛋白的蛋白激酶IRNA结合基序蛋白质3BRF1同系物；RNA聚合酶III转录起始因子IIIB的亚基(酿酒酵母)骨髓/淋巴或混合性白血病(三空腔同系物；果蝇)；已易位；6N-己基顺丁烯二酰亚胺敏感性因子5-羟色胺(血清素)受体7(腺苷酸环化酶偶联的)KIAA0100基因产物GCN5普通控制的氨基酸合成5样2(酵母)RNA结合基序蛋白质；Y染色体；家族2；成员B3′-磷酸腺苷5′-磷硫酸合酶1七跨膜蛋白质TM7SF3核心结合因子；runt结构域；α亚基2；已易位；3H2A组蛋白家族；成员CDNA交联修复1A(PSO2同系物；酿酒酵母)HSPC135蛋白质S100钙结合蛋白质A9(钙粒蛋白B)普通转录因子IIIC；多肽3(102kD)跨膜4超家族成员3精液相关抗原9生长因子受体结合蛋白质10KIAA0470基因产物   177.1237105.8303132.7839118.5733150.1968113.9231140.1356150.0469180.7113138.9363218.7666105.9471129.4527112.3917194.4946138.0932489.0924145.0821119.2486160.3109144.7319138.644129.5468110.7683120.8593190.3667   16615211012413013593.211512295.718122210615318823748.184.1307135163220103139115103   107.454107.465107.4694107.5998107.6187107.6204107.7553107.7567107.7762107.8044107.8181107.8612107.863107.9125107.9154107.9483107.9969108.023108.208108.2493108.2576108.3524108.6355108.6913108.7182108.9005   150.3287121.8015116.7347116.7128129.259118.8965113.6891124.3969136.7788114.1635169.3507145.1883114.5758124.4395163.4169160.8518215.0608112.4051178.2467134.6437138.5985155.7377113.7491119.4574114.7351134.0152   -7.21E-012.21E-02-3.05E-01-1.40E-01-4.81E-01-8.21E-02-3.79E-01-4.78E-01-7.46E-01-3.66E-01-1.02E+002.58E-02-2.63E-01-5.87E-02-8.50E-01-3.55E-01-2.18E+00-4.26E-01-1.40E-01-5.67E-01-4.19E-01-3.56E-01-2.54E-01-2.73E-02-1.53E-01-8.06E-01   -9.00E-025.23E-01-2.72E-016.42E-02-2.09E-012.46E-01-5.89E-01-3.79E-01-5.69E-01-5.37E-01-2.70E-011.07E+00-2.83E-014.45E-01-5.02E-027.76E-01-3.35E+00-7.87E-011.37E+00-2.44E-011.70E-016.68E-01-3.30E-013.27E-01-7.64E-02-8.89E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P57053Q92876P09960Q9HBH1P55082Q9NVH6O95249Q13891Q9BZM5O94913Q12987Q92499Q13686P43250Q9UMX0O94905Q9UHK0P25189Q10567O15230P52294O60668P11686Q9NWB6Q9H028Q9UMZ2P24752P11230   J20gh6J03ab8F21ab6O02gh5L15ab7B01gh3K10cd5M15ab6H05gh7O20ef2E03ef4D05ab5B19ab2I08ab4L03ef4G12cd7K01cd8D01ab6M11ab2D18cd8J10ab6M03cd2J02cd1P03gh2E22gh8O22cd7C15ab2B06ab3   H2B组蛋白家族；成员S激肽释放酶6(甘油磷酸钙；酵母)白细胞三烯A4水解酶肽去甲酰酶样蛋白质微原纤维相关蛋白质3三甲基赖氨酸羟化酶；ε高尔基SNAP受体复合物成员1碱性转录因子3；类2UL16结合蛋白质2PCF11p同系物酸性82kDa蛋白质mRNADEAD/H(Asp-Glu-Ala-Asp/His)盒多肽1烷基修复；alkB同系物G蛋白偶联受体激酶6ubiquilin 1染色体8开放阅读框2细胞核脆性X综合征蛋白质互作蛋白质1髓磷脂P0蛋白(夏-马-图三氏神经病变1B)接头相关蛋白质复合物1；β1亚基层粘连蛋白；α5karyopherinα1(importinα5)TAF2RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；150kD表面活化剂；肺相关蛋白质C假000000定蛋白质FLJ10154组蛋白脱乙酰基酶10AP1γ亚基结合蛋白质1乙酰辅酶A转乙酰酶1(乙酰乙酰辅酶A硫解酶)胆碱能受体；烟碱；β多肽1(肌肉)   113.6057197.297996.36818138.0653121.4467174.7559107.5878126.6543133.6731205.6752132.1136176.6983105.5169120.3579122.0111127.8659157.4757110.5502208.9283111.864178.7513123.6244136.0267174.7789107.5034120.2821216.1409106.1774   1991301859112481.614312024580.311712414311314110787.613218714116911111775138119114151   108.9238108.9308109.0526109.0612109.134109.1442109.1657109.1942109.2193109.2409109.4318109.4356109.4797109.4844109.5522109.6202109.6296109.6859109.8204109.8469109.9831110.0571110.0847110.1306110.1585110.2219110.2562110.2999   140.5964145.5667130.2822112.7249118.1545121.828119.983118.5076162.5485131.7517119.3623136.6656119.4385114.2814124.0398114.8261118.2396117.3068168.4738120.9363152.7331114.8794121.0017119.9579118.4626116.5628146.8035122.607   -6.07E-02-8.57E-011.78E-01-3.40E-01-1.54E-01-6.79E-012.10E-02-2.14E-01-2.91E-01-9.13E-01-2.72E-01-6.91E-015.32E-02-1.37E-01-1.55E-01-2.22E-01-5.22E-01-1.13E-02-9.28E-01-2.63E-02-7.01E-01-1.68E-01-3.05E-01-6.66E-013.52E-02-1.26E-01-9.71E-015.50E-02   8.11E-01-5.97E-019.44E-01-6.01E-012.87E-02-1.10E+004.12E-01-8.18E-028.73E-01-1.36E+00-1.81E-01-5.13E-014.42E-01-9.10E-022.04E-01-2.57E-01-8.46E-012.52E-01-1.62E-013.35E-01-7.70E-02-1.56E-01-2.19E-01-1.22E+003.57E-01-1.32E-02-9.23E-015.11E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O14977P56937O75299P16219Q9NZ48Q9P163Q9BVT8Q99933O14645Q9BRR9Q9Y3E7P46976O75928Q9NX63Q9UBS0Q15185O60516Q16651P48788Q01968Q9H6Z6Q9NQ55O95359P01189Q9Y525   O18ef2E15ef5N06ef2B21ab7C09ab2J20gh3L10gh4I07gh8E02ef6M12cd3E01gh8J19ef2C09ab6C01cd5I18gh2I20cd2F18cd6J18cd3J01ab8E22cd2N06ab7L11gh7B01gh4A24gh1I15ab8G13cd8   鸟氨酸脱羧酶抗酶蛋白抑制剂T细胞受体β基因座羟基类固醇(17-β)脱氢酶7驱动蛋白家族成员C3脂酰辅酶A脱氢酶；C-2-C-3短链非特征性造血干/祖细胞蛋白质MDS026假定蛋白质PRO2521假定蛋白质MGC5442BCL2相关athanogene动力蛋白；基因丝；轻链中间体多肽Rho GTP酶活化蛋白质9CGI-149蛋白质糖原引发蛋白活化的STAT X的蛋白质抑制剂假定蛋白质FLJ20420核糖体蛋白质S6激酶；70kD；多肽2未活化的孕酮受体；23kD真核翻译起始因子4E结合蛋白质3蛋白酶；丝氨酸；8(前列腺)肌钙蛋白I；细胞骨架；快速Lowe眼-脑-肾综合征假定蛋白质FLJ21628peter pan同系物(果蝇)转化；酸性包含卷曲螺旋的蛋白质2阿黑皮素原(促肾上腺皮质激素/β-促脂解素/α-促黑素细胞激素/β-促黑素细胞激素/β-内啡呔)v-maf肌腱膜纤维肉瘤癌基因同系物F(鸟类)   119.9172139.7091227.1137113.15109.4688112.5665101.1317135.5302119.7332164.1806120.3646158.4397127.650298.84393123.3725186.953169.4269104.3739334.0498121.3602169.0079115.1546122.449108.2194145.0634119.023   12984474.512813618915913711520711520211717315915572.314712511095.912612013990.4141   110.3110.3287110.3428110.3535110.3636110.3995110.4184110.5044110.533110.5493110.5606110.6074110.6815110.7286110.8068110.8188110.8534110.9085110.9253110.9357110.9507111.0337111.0627111.0999111.1389111.1934   119.7626364.6946137.3284117.1803118.69137.2614123.4514127.7419115.0469160.4204115.1711157.1807118.5706127.4786131.146150.9199117.54120.8526190.1399114.1376125.3025117.2667117.676119.4624115.5442123.6546   -1.21E-01-3.41E-01-1.04E+00-3.61E-021.17E-02-2.80E-021.27E-01-2.95E-01-1.15E-01-5.71E-01-1.23E-01-5.18E-01-2.06E-011.64E-01-1.55E-01-7.54E-01-6.12E-018.76E-02-1.59E+00-1.30E-01-6.07E-01-5.26E-02-1.41E-013.79E-02-3.84E-01-9.82E-02   1.06E-012.59E+00-1.61E+001.78E-013.16E-017.46E-016.51E-011.76E-02-5.98E-023.31E-01-7.10E-023.54E-01-1.21E-018.06E-013.68E-01-2.71E-01-1.23E+004.97E-01-1.41E+00-1.40E-01-8.17E-011.25E-01-3.50E-023.62E-01-6.82E-012.42E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9UHC9Q9HBT2O00219P22735O15388O95389Q06190P50226Q16632P54762Q15269O14495Q9P0U0P50120Q9UHR0Q13977P51692P51164Q9NXH3P16435Q02080Q15334P10636Q9Y4J6Q9UHY7   L09cd8P14gh7M22ef1M16cd1A11ab4J01cd4D21ab8C03cd3N10ab5A24ef7E15cd1H10cd3N24ef3J02ab8D08gh1A12ef1C18cd8N12ab2C02gh2C04gh7G16ef6E05gh6L03ab7J06ab7J13ab7A01gh2P18gh4  NPC1(尼曼-皮克病；C1型；基因)-样1假定蛋白质PP1057透明质烷合酶3转氨酶1(K多肽表皮I型；蛋白谷氨酰胺γ-谷氨酰转移酶)唾液酸结合Ig样凝集素6WNT1可诱导信号通路蛋白质3蛋白质磷酸酶2(从前2A)；调节亚基B″；α磺基转移酶家族；细胞溶质部分；1A；嗜酚；成员2普通转录因子IIIC；多肽2(β亚基；110kD)EphB1PWP2周期性丝氨酸蛋白质同系物(酵母)磷脂酸磷酸酶2B型PC326蛋白质视黄醇结合蛋白2；细胞的G蛋白偶联受体激酶7小脑退化相关蛋白质(62kD)信号传导子及转录激活子5BATP酶；H+/K+交换；β多肽蛋白磷酸酶1；调节(抑制剂)亚基14DER到核信号蛋白2P450(细胞色素)氧化还原酶假定蛋白质MGC5338MADS盒转录增强子因子2；多肽B(肌细胞增强子因子2B)致命性巨幼虫同系物1(果蝇)微管相关蛋白质T锌指蛋白6(CMPX1)E-1酶   107.7403147.5097224.5087136.8808105.2847134.8825134.6973147.6874120.7982107.3397125.0688120.761152.5639231.806111.83105.2052126.7779136.4695113.3081112.9203110.2003116.1511138.6124123.3076115.8818138.8767108.9217   13898899114794102101116168107109101217151180100112127125132137100110142102134   111.3741111.4385111.4539111.5589111.6016111.6123111.8192111.8328111.85111.8669111.8713111.9087111.9543111.9639111.9778112.0477112.0645112.2007112.2521112.2701112.2899112.3522112.3745112.3893112.4092112.4376112.5485   118.9021118.9743141.641113.1407121.3043113.4959116.2494120.0792116.1383129.1191114.654113.9808121.9267187.0028124.9147132.4319112.9412120.3347117.6836116.8658118.227121.7814117.0502115.3049123.46117.8247118.5336   4.79E-02-4.05E-01-1.01E+00-2.95E-018.41E-02-2.73E-01-2.69E-01-4.01E-01-1.11E-015.96E-02-1.61E-01-1.10E-01-4.47E-01-1.05E+001.91E-039.09E-02-1.78E-01-2.82E-01-1.35E-02-8.33E-032.71E-02-4.80E-02-3.03E-01-1.34E-01-4.39E-02-3.05E-014.73E-02   3.53E-01-5.90E-01-1.34E+00-5.89E-014.82E-01-5.21E-01-3.98E-01-5.52E-01-6.14E-026.48E-01-2.25E-01-1.44E-01-5.91E-01-9.36E-024.33E-017.75E-01-3.43E-01-2.81E-011.70E-011.51E-012.62E-012.36E-01-4.69E-01-1.62E-012.94E-01-4.43E-013.00E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q14147O95880Q15013Q9P1E2P07203Q13206O15085P48426Q9NRQ2O43171Q9HB90Q9H733P43353Q15053P22301Q9BW47P21917Q9Y6K5Q9Y2A4Q16880O95747P25106P45984Q9NPF7Q9UH94Q16559Q9UGH0   K04gh1N06gh4J23ef3E01gh4H23ef1M07ab5L15ef3C07cd1K20gh4B24cd3M02gh5I21gh5C06ab2G14gh1H01ef7N12gh5M03ab6M19cd1N22cd5A16cd3D09cd5L12ef4H23ab6L18ef5I03ef3L07cd8F05cd2C02cd8   DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽34KIAA1513蛋白质从具有完整编码序列的cDNA预测的基因假定蛋白质PRO2219谷胱甘肽过氧化物酶1DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽10(RNA解旋酶)Rho鸟嘌呤核苷酸交换因子(GEF)11磷脂酰肌醇-4-磷酸5-激酶；II型；α磷脂酰融合酶4CDC14细胞分裂周期14同系物A(酿酒酵母)Rag C蛋白质单一Ig IL-1R相关分子醛脱氢酶3家族；成员B1KIAA0040基因产物白细胞介素10染色体20开放阅读框116多巴胺受体D42′-5′寡腺苷酸合成酶3(100kD)Kruppel型锌指(C2H2)UDP糖基转移酶8(UDP-半乳糖神经酰胺半乳糖转移酶)氧化应激反应蛋白1G蛋白偶联受体免疫球蛋白超家族；成员3促分裂原活化蛋白激酶9白细胞介素23；α亚基p19促乳素调节元件结合T-细胞急性淋巴细胞性白血病2溶质载体家族17(阴离子/糖转运蛋白)；成员5   117.5358168.2097104.556138.6039120.5127140.5274121.8405232.9191126.2397126.784132.9037113.5449141.7651111.1705174.8595125.8289158.6974127.2648136.0849112.9309113.39100.7123102.6971139.416898.83593140.4102131.497498.73308   11910419810711492.511116311611313613710114610815415114213313312314714588182106111158   112.7866112.9115113.0807113.1066113.1788113.1804113.2492113.2533113.2849113.382113.4299113.4753113.5244113.5775113.5877113.6231113.7899113.9993114.1396114.1612114.2384114.2482114.3219114.3405114.4153114.4158114.5482114.6616   116.4348128.5046138.5918119.6869115.8519115.4153115.3055169.6778118.4782117.8862127.5658121.334118.734123.496132.021131.1841141.2355127.6931127.5854119.9407116.7318120.5368120.6924113.914131.5891120.3231118.9991123.6748   -5.95E-02-5.75E-011.13E-01-2.93E-01-9.06E-02-3.12E-01-1.05E-01-1.04E+00-1.56E-01-1.61E-01-2.29E-01-8.84E-04-3.21E-013.09E-02-6.22E-01-1.47E-01-4.80E-01-1.59E-01-2.54E-011.56E-021.08E-021.82E-011.55E-01-2.86E-012.11E-01-2.95E-01-1.99E-012.16E-01   1.76E-02-6.88E-019.22E-01-3.69E-01-8.19E-02-6.03E-01-1.37E-01-5.16E-01-1.23E-01-1.60E-013.71E-022.71E-01-4.90E-013.91E-01-7.00E-012.92E-01-6.96E-021.56E-01-3.82E-022.33E-011.12E-015.42E-014.98E-01-6.64E-018.77E-01-4.04E-01-2.45E-016.75E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q15544O00628O43241Q9Y6N1Q9UHX5Q01664Q9BUI1Q9HBL5Q9NXV2Q15424P26440O60264Q15286Q9UGK0Q92980Q99726P01111Q92574P16106Q9NWX5Q9Y6B7Q9Y4F1   J13cd2N24ab7F07ab5M14ab4O01ef4A02cd2O03gh6M17gh4N08gh2D08cd1F06ab6J11cd3K07cd7I10ef4J06cd5M06cd3O17ab8G13cd3C01gh7O24gh2M05ab3J04cd5 TAF11RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；28kD过氧化物酶体生源因子7高尔基体自身抗原；高尔基体亚家族a；3COX11同系物；细胞色素c氧化酶装配蛋白质(酵母)HT002蛋白质；高血压相关的钙调性基因转录因子AP-4(活化增强子结合蛋白质4)白细胞受体集簇(LRC)成员4AD023蛋白质假定蛋白质FLJ20040支架附着因子B异戊酰辅酶A脱氢酶SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族a；成员5RAB35；成员RAS癌基因家族DIPB蛋白质类似于nessy的推断蛋白质(果蝇)溶质载体家族30(锌转运蛋白)；成员3成神经细胞瘤RAS病毒(v-ras)癌基因同系物结节性硬化症1H3组蛋白家族；成员I假定蛋白质FLJ20548接头相关蛋白质复合物4；β1亚基FERM；RhoGEF(ARHGEF)和普列克底物蛋白结构域蛋白质1(软骨细胞来源)   117.4634156.16123.9421127.120398.26523268.3453112.2417103.9999126.6647134.9613178.7093105.7775138.2766303.2745142.089112.8008123.6283109.8519134.9364118.1581217.8572108.6215   12396.910410015566.712513714792.7115132183172181121108128118112170130   114.6792114.7281114.8381114.8993114.9242115.0377115.039115.0443115.1386115.1845115.2412115.2498115.3443115.4096115.4166115.4854115.5932115.7107115.868115.9919116.0173116.0342   118.4317122.588114.422114.0678122.8348150.0321117.3611118.5457129.6462114.2781136.2534117.7402145.6196.7868146.2003116.3247115.8629117.8303122.8016115.5043168.0108118.0819   -3.46E-02-4.45E-01-1.10E-01-1.46E-012.26E-01-1.22E+003.55E-021.46E-01-1.38E-01-2.29E-01-6.33E-011.24E-01-2.62E-01-1.39E+00-3.00E-013.39E-02-9.70E-027.50E-02-2.20E-01-2.67E-02-9.09E-019.52E-02   6.82E-02-6.89E-01-2.46E-01-3.44E-016.60E-01-2.01E+001.53E-013.93E-012.16E-01-5.42E-01-6.38E-013.22E-014.06E-01-8.21E-013.50E-019.75E-02-1.90E-012.20E-01-1.98E-01-7.26E-02-3.57E-012.55E-01   1111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q06710Q9H6N1Q9NSY1Q14106Q9UK11P08069Q9H6F5Q14373P20393P36915O95109Q9NVS2Q92950Q14977P16106Q9Y3C1P37287Q9UIG5Q9UNE2Q14123Q16206Q9NWT1Q12756P28288P05198Q9H0V9Q92984O95498Q9H1E1Q9NV88Q9Y310   M14cd3J17gh5K09gh3H20cd6B02ef4O17ef6I21gh6O04ab3G04ef5O01ab5G02cd8I24gh3B08cd6C04ab7O04gh6N18ef2C11ef1G05ef4G15cd6A17cd1P03ab2D21gh2C05ab3B10ab8G08ab5D08gh7M10ef1A13cd5J01gh8H01gh3F06cd6  配对盒基因8假定蛋白质FLJ22056小鼠BMP-2可诱导激酶同系物ERBB2转导蛋白；2锌指蛋白223胰岛素样生长因子1受体假定蛋白质MGC2574半乳糖-1-磷酸尿苷酰基转移酶核受体亚家族1；D组；成员1鸟嘌呤核苷酸结合蛋白样1染色体20开放阅读框14线粒体核糖体蛋白质S18ACUG三联重复；RNA结合蛋白质2SP110核小体蛋白质H3组蛋白家族；成员A假定蛋白质HSPC111磷脂酰肌醇聚糖；A类(阵发性夜间血红蛋白尿)SEEK1蛋白质Rab亲和蛋白3A样(无C2结构域)磷酸二酯酶1C；钙依赖性(70kD)细胞溶质卵巢癌抗原1假定蛋白质FLJ20624突触泡的轴突转运ATP结合盒；亚家族D(ALD)；成员3真核翻译起始因子2；亚基1(α；35kD)假定蛋白质DKFZp564L2423干扰素诱导蛋白质35vanin 2核糖核酸酶7假定蛋白质FLJ10871SnRNP装配缺陷1同系物   120.1357214.4909111.9034117.9634119.1221106.3434120.5097157.7476107.1138120.9306143.5728117.9573109.8876107.096994.76745145.1935132.5354102.5149110.3023121.3078116.5183116.0517138.4398140.4464115.5074128.832258.0737109.7731109.332108.5849119.9305   12924212313413317811223113811110312412915815916410914812313215711623295.9119101221123131125113   116.1006116.2509116.2514116.2536116.2873116.3103116.3129116.3555116.4228116.4819116.5321116.6011116.7366116.8973116.9796117.0185117.2467117.279117.2874117.3754117.4492117.4816117.5489117.5959117.6033117.6689117.8182117.8273117.8377117.8411117.8563   121.7641190.8582117.0914122.8358122.8322133.4883116.1638168.3955120.571116.2706121.0452119.5497118.6125127.3783123.5385141.934119.4716122.443117.0111123.5304130.1671116.4708162.7767117.9674117.2266115.9248198.9799116.8572119.4295117.172117.0556   -4.93E-02-8.84E-015.50E-02-2.11E-02-3.47E-021.29E-01-5.11E-02-4.39E-011.20E-01-5.41E-02-3.01E-01-1.67E-028.72E-021.26E-013.04E-01-3.11E-01-1.77E-011.94E-018.86E-02-4.75E-021.15E-021.77E-02-2.36E-01-2.56E-012.59E-02-1.31E-01-1.13E+001.02E-011.08E-011.18E-01-2.52E-02   1.03E-011.73E-011.38E-011.87E-011.60E-017.42E-01-1.10E-015.51E-013.67E-01-1.18E-01-4.79E-017.31E-022.34E-015.62E-017.45E-011.72E-01-2.87E-015.25E-011.62E-011.21E-014.26E-01-2.15E-037.47E-01-5.51E-013.77E-02-3.47E-01-2.23E-011.64E-012.62E-012.04E-01-8.10E-02   1111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P48382P52738Q9NRW1O15298Q9NUN5Q07699P27701Q9UER5Q8TAC6Q9NRW9O95147Q13895P31645P51511Q15154Q00007P55822Q14442P54792P42336Q9UMQ3Q9UPY5P19113O95394P22557   O06cd1K04cd3G23ef3A02ab3D14gh3L03cd1F10ab6O02ef3I24gh7K16gh4O15cd7A19ef7N03ef5N17ef7O11cd1E17ef6L08cd2L20ab8L04ab4A03ef6G15ab3M04ef3H01ef6B16ef3A14ab2   调节因子X；5(影响HLA II类表达)锌指蛋白140(克隆pHZ-39)RAB6B；成员RAS癌基因家族碱性亮氨酸拉链核因子1(JEM-1)假定蛋白质FLJ11240钠道；电压门；I型；β多肽kangai 1(抑制致瘤性6；前列腺；CD82抗原(R2白细胞抗原；单克降抗体IA4检测的抗原))TNF-诱导的蛋白质染色体11开放阅读框17血管紧张素II；I型受体相关蛋白质双特异性磷酸酶14bystin样溶质载体家族6(神经递质转运蛋白；血清素)；成员4基质金属蛋白酶15(插入膜的)中心粒周围物质1蛋白质磷酸酶2(从前2A)；调节亚基B(PR 52)；α同工型SH3结构域结合富含谷氨酸蛋白质磷脂酰肌醇聚糖；H类dishevelled；dsh同系物1(果蝇)磷酸肌醇-3-激酶；催化型；α多肽BarH样同源异形盒2溶质载体家族7；(阳离子氨基酸转运蛋白；γ+系统)；成员11组氨酸脱羧酶N-乙酰葡糖胺磷酸变位酶氨基酮戊酸；δ-；合酶2(高铁成红细胞性低色素性贫血)   191.5142136.6586100.578266.9887114.5392116.5431116.2761104.9755117.4257136.6357181.9968108.0232114.6464122.9018127.8378108.364131.7189121.0635126.677101.090599.5713173.9407111.9277124.8164202.1179   12215417911011611310813113810520012418912513912313311411314317969.5119112129   118.0773118.1501118.1659118.2062118.2691118.3239118.3881118.4653118.5887118.6777118.7007118.7967118.8487118.8609118.8759118.9838119.0263119.0306119.067119.1581119.1741119.3079119.3155119.3184119.3857   143.9771136.2205132.4668165.1797116.1573115.8757114.2624118.2694124.5089120.1901166.9415116.9004140.7231122.1739128.7076116.7703128.0275118.0476119.4338121.01132.6879120.9226116.6743118.8198150.2281   -6.98E-01-2.10E-012.32E-01-1.18E+004.62E-022.19E-022.60E-021.74E-011.42E-02-2.03E-01-6.17E-011.37E-015.19E-02-4.82E-02-1.05E-011.35E-01-1.46E-01-2.44E-02-8.94E-022.37E-012.59E-01-5.44E-019.22E-02-6.50E-02-7.60E-01   -6.47E-011.71E-018.29E-01-1.27E+001.41E-02-4.76E-02-1.05E-013.24E-012.28E-01-3.76E-011.37E-011.98E-017.19E-012.16E-021.25E-011.82E-011.76E-02-8.61E-02-1.70E-014.98E-018.49E-01-1.32E+008.57E-02-1.52E-01-6.46E-01   1111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y3A2Q9H5J4P16083Q99819O75569O15038Q9HBH5P41231O15397Q9UDY8O95819Q12999P25440P20827Q9H652P31483Q9BSM8P36897Q9UMR9Q92560Q9NWU1Q92696O95236Q13202P11277O95397P05423   G10ef2I05gh6E15ab8D02ab2F06cd3F12ef7K09gh4C22ab8D01cd6C17cd7E22cd5J01ef5D07cd2H21ef7P20gh8L20ef4G15gh8F04ef5E08ef3G11ab3D05gh2N14ab8M24ef3E21ab5M02cd1P18ef1A20ab3  CGI-94蛋白质长链脂肪酰延伸酶NAD(P)H脱氢酶；醌2Rho GDP解离抑制因子(GDI)γ蛋白激酶；干扰素可诱导性双链RNA依赖性活化子丝氨酸/精氨酸重复基质2PAN2蛋白质嘌呤受体P2Y；G蛋白偶联；2RAN结合蛋白质8粘膜相关淋巴样组织淋巴瘤易位基因1促分裂原活化蛋白激酶激酶激酶激酶4肉瘤放大序列包含bromodomain的2ephrin-A1假定蛋白质MGC4171TIA1细胞毒颗粒体相关RNA结合蛋白质假定蛋白质MGC10812转化生长因子；β受体I(活化素A受体II型样激酶；53kD)YME1样1(酿酒酵母)BRCA1相关蛋白质1(泛素羧基端水解酶)假定蛋白质FLJ20604Rab香叶基香叶基转移酶；α亚基载脂蛋白L；3双特异性磷酸酶8血影蛋白；β；红细胞的(包括球形细胞增多症；临床I型)推断的糖脂转移蛋白质BN51(BHK21)温度敏感性互补   108.7497135.0119154.7986125.7962100.3086125.19102.0601131.9219114.6925114.476992.42403114.9397116.6707298.0458129.5733105.4425148.2279115.7567256.0314101.3699.76081222.7157106.592146.3963112.7299.78536131.8122   1678798.610613796.613913011812015611010876010712927310819716115427213012911414395.5   119.4751119.5181119.5724119.5853119.6257119.719119.7321119.8105119.9197119.9403119.956119.9579120.0152120.3333120.4428120.5386120.573120.6724120.7227120.7575120.7609120.7706120.798120.7987120.8055120.8708120.9201   131.6512113.8461124.3296117.2457118.9057113.8294120.3437127.3275117.4304118.129122.7769114.8641114.7701392.8203118.9065118.2227180.6391114.8546191.0958127.8687124.8325205.3234119.1528131.9045116.0084121.1071116.0734   1.36E-01-1.76E-01-3.73E-01-7.30E-022.54E-01-6.45E-022.30E-01-1.39E-016.43E-026.73E-023.76E-016.17E-024.08E-02-1.31E+00-1.05E-011.93E-01-2.98E-016.00E-02-1.08E+002.53E-012.76E-01-8.83E-011.80E-01-2.77E-019.99E-022.77E-01-1.24E-01   6.16E-01-6.34E-01-6.50E-01-2.42E-014.47E-01-3.74E-014.48E-01-1.84E-023.71E-026.76E-027.55E-01-6.74E-02-1.16E-011.35E+00-2.80E-012.87E-018.82E-01-9.83E-02-3.82E-016.72E-016.26E-012.91E-012.87E-01-1.88E-012.26E-025.16E-01-4.65E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q14338Q9BYI8Q06203Q9NZ33P04196O96029Q01196Q9UHL4P55211P21283O43422P78406P43362Q9H693Q9UJ83Q05048P19784Q9BUX8Q9Y5P6Q9Y3E1P40426P11217Q16563O95698   I17ab6A22gh8D01ab8P10gh4O10ab6F03cd7I16ab5J17cd8P16ab3A07ab3P02ab8L01cd3J18ab7E12gh6A11cd8I15ab4D11ab4D06gh6D23cd8F16ef1O07cd1K01cd1D18cd2L07ab6   岩藻糖基转移酶2(包括分泌物状态)AIE-75结合蛋白蛋白质磷核糖基焦磷酸氨基转移酶脑表达；X连锁1富含组氨酸糖蛋白阿片样生长因子受体runt相关转录因子1(急性髓细胞样白血病1；aml1癌基因)二肽基肽酶7半胱天冬酶9；凋亡相关半胱氨酸蛋白酶ATP酶；H+转运；溶酶体42kD；V1亚基C；同工型1蛋白激酶；干扰素可诱导的双链RNA依赖性抑制剂；阻遏物(P58阻遏物)RAE1RNA输出1同系物(稷酒酵母)黑素瘤抗原；家族A；9假定蛋白质FLJ224772-羟基植烷酸-辅酶A裂合酶断裂刺激因子；3′前RNA；亚基1；50kD酪蛋白激酶2；α主要多肽酵母核糖体生源调节蛋白质同系物RRS1GDP-甘露糖焦磷酸化酶B肝癌来源的生长因子2前B细胞白血病转录因子3磷酸化酶；糖原；肌肉(McArdle综合症；糖原储存病V型)突触泡蛋白样蛋白质生长家族抑制剂；成员1样   99.7191590.11911216.3154113.8613116.1305201.3579441.1217180.3445113.5416288.6034131.8635147.119299.05783171.769999.45467124.160994.68573167.4752166.457297.00713122.6888314.804197.62823102.2388   18116410516211693.513619111128810097.113996.414110515217889.414894.8110144135   120.9483121.0209121.029121.0508121.1163121.2888121.3316121.351121.3742121.3828121.394121.4625121.5326121.6097121.6399121.6764121.7819121.8214121.8219121.9163121.9253122.008122.0944122.1358   133.9938125.1864147.3953132.4428117.5882138.7174232.9078164.207115.3899232.7446117.7416121.9098119.97129.9396120.5495117.088122.6579155.6701125.8828122.172113.1427182.286121.3173119.6732   2.78E-014.25E-01-8.38E-018.83E-026.06E-02-7.31E-01-1.86E+00-5.72E-019.62E-02-1.25E+00-1.19E-01-2.76E-012.95E-01-4.98E-012.91E-01-2.92E-023.63E-01-4.59E-01-4.50E-013.30E-01-9.01E-03-1.37E+003.23E-012.57E-01   8.63E-018.67E-01-1.04E+005.12E-01-7.63E-03-1.11E+00-1.69E+008.23E-02-2.94E-02-1.78E-03-4.00E-01-5.99E-014.92E-01-8.33E-014.99E-01-2.36E-016.78E-018.56E-02-8.97E-016.05E-01-3.72E-01-1.52E+005.63E-013.97E-01   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P19447Q9UK39Q15785Q99571Q9BTY2Q9P0P1Q9Y324P37286Q00577O75152P23610O75436Q9HA40Q9NX62O76062Q16445Q08462P78560P19634P28370Q92503Q9UL02Q9Y5T5   K24ef6D08cd7E23cd7C14ab8E24gh8D12ef1P01ef1O17cd3O07ef5L21gh1H06cd7M20cd5B23gh5I20gh2E04cd2H02ab3G11ef6A22ef6N17ef5N12cd1H06cd1H24ef1J13cd6G03gh8   切除修复交叉互补啮齿类修复缺陷；互补组3(着色性干皮病B组互补)CCR4碳分解代谢产物阻遏4样(酿酒酵母)线粒体外膜易位酶34嘌呤受体P2X；配体门控性离子通道；4类似于岩藻糖苷酶的假定蛋白质MGC1314；α-L-1；组织假定蛋白质FLJ10769CGI-35蛋白质泛素缀合酶E2H(UBC8同系物；酵母)富含嘌呤元件结合蛋白质AKIAA0663基因产物凝血因子VIII相关(内含子转录物)空泡蛋白质分选26(酵母)类似于信号素的假定蛋白质FLJ12287假定蛋白质FLJ20421跨膜7超家族成员2γ-氨基丁酸(GABA)A受体；α6腺苷酸环化酶2(脑)带有死亡结构域的包含CASP2和RIPK1结构域的接头溶质载体家族9(Na/H交换物)；同工型1(反向转运体；Na+/H+；盐酸阿米洛利敏感)SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族a；成员1SEC14样1(酿酒酵母)L-犬尿素/α-氨基苯甲醚转氨酶泛素特异性蛋白酶16原钙粘蛋白15   95.41189173.8761296.8521418.1812131.9449147.9172129.111898.88763116.0341101.4464164.911118.1135104.6286103.7764301.1903150.641107.541108.4508118.9969115.471151.5939105.6951117.1056153.0978   14826214441091.51919716512314010310812613621587.514615399106151124120126   122.1425122.1589122.1776122.3053122.3524122.4861122.5531122.5669122.5705122.5789122.5902122.6522122.666122.701122.7645122.7829122.8502122.8627122.898122.9184122.9424123.0487123.0646123.1548   121.7269185.8825187.6861316.7241115.258153.8845116.2093128.7921120.658121.2139130.3149116.2363117.8494120.7522212.8749120.3177125.3933128.1152113.6214114.9572141.9225117.4294120.0007134.1729   3.56E-01-5.09E-01-1.28E+00-1.77E+00-1.09E-01-2.72E-01-7.52E-023.10E-017.91E-022.73E-01-4.28E-015.44E-022.29E-012.42E-01-1.29E+00-2.95E-011.92E-011.80E-014.65E-029.02E-02-3.02E-012.19E-017.16E-02-3.14E-01   6.30E-015.89E-01-1.04E+00-2.96E-02-5.28E-013.71E-01-4.13E-017.38E-018.84E-024.61E-01-6.73E-01-1.30E-012.71E-013.88E-01-4.89E-01-7.83E-014.39E-014.97E-01-2.66E-01-1.17E-01-3.46E-032.25E-013.32E-02-2.78E-01   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P15848Q9UP66O75160P78385O94967O95719P48147P20231O95299O75033P51668P28289Q15631P49888P51959Q9Y5V0P56270Q9HD23P78358O00327Q9H969O15504P35250Q9BXC0O15232O76049Q14145P20848Q9P0N6   H02ab2P24ab6P07gh1L14ab6B21ef8K01cd5F09ab8B15gh7G02ab7I18gh1D03cd4E08cd2O12ef6F03cd2O12ef5J16ef1I12ef1O11gh4O03ab6D24ab2F08gh5F01cd7I24ef6F17gh8A19ef1L19cd5C21cd8A10cd1C19ef3   芳基硫酸酯酶B低密度脂蛋白受体相关蛋白质5KIAA0672基因产物角蛋白；头发；碱性；3KIAA0893蛋白质异嗜性和多嗜性逆转录病毒受体脯氨酰内肽酶类胰蛋白酶β2NADH脱氢酶(泛醌)1α子复合物；10(42kD)KIAA0445基因产物泛素缀合酶E2D 1(UBC4/5同系物；酵母)原肌球调节蛋白trnnslin磺基转移酶；雌激素嗜性细胞周期蛋白G1HSPC038蛋白质MYC相关锌指蛋白(嘌呤结合转录因子)MRS2样；镁平衡因子(酿酒酵母)癌症/睾丸抗原1芳烃受体细胞核转运蛋白样假定蛋白质FLJ12969核孔蛋白样蛋白质1复制因子C(激活子1)2(40kD)G蛋白偶联受体81matrilin 3血影蛋白SH3结构域结合蛋白质1Kelch样ECH相关蛋白质1丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade A(α-1抗蛋白酶；抗胰蛋白酶)；成员2假定蛋白质HSPC242   149.4791114.2435121.9398100.70392.15324108.0877130.0641106.6865107.385121.519699.84401303.877173.134122.2586116.6841114.0123248.3395140.8864217.9167118.200889.23821200.4449111.3418104.4833113.1634171.9625193.967197.77909112.0065   95.612411713515812212913012912213727215295.1102179140117137185177124112128110299120161109   123.1651123.2083123.2554123.2569123.2707123.3497123.3564123.4905123.5991123.624123.637123.6484123.6887123.7564123.7661123.7928123.8618123.8621123.9307123.9698124.0248124.2046124.3534124.3568124.4317124.5037124.5928124.6004124.6034   122.7499120.4437120.8501119.6793124.6247117.7043127.6048119.9323119.8634122.4835120.3233.0271149.5989113.6937114.0387139.0584170.7774127.1502159.681142.5298130.1172149.5876115.9922118.786115.8185198.6303146.2645127.9292115.304   -2.79E-011.09E-011.55E-022.92E-014.20E-011.91E-01-7.64E-022.11E-012.03E-012.48E-023.08E-01-1.30E+00-4.85E-011.76E-028.50E-021.19E-01-1.00E+00-1.86E-01-8.14E-016.87E-024.75E-01-6.90E-011.59E-012.51E-011.37E-01-4.66E-01-6.39E-013.50E-011.54E-01   -6.45E-011.17E-01-5.53E-024.24E-017.82E-011.71E-01-7.45E-032.81E-012.60E-019.32E-034.61E-01-1.62E-01-1.88E-01-3.63E-01-1.99E-016.54E-01-8.26E-01-2.72E-01-6.68E-016.50E-019.89E-01-6.92E-011.21E-022.87E-01-4.27E-028.00E-01-6.90E-017.23E-01-3.53E-02   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P05188Q9UBJ4Q13876Q9UBF2P43026Q9HD20Q96KK6P40617O75651Q9Y2S1Q13330Q9Y389O60513O00212Q9NXE1O95405P01112O15120P12645P50579O14908Q9HCC6Q15737Q9Y519   E12ab2A01gh5I24ef7F12cd7I23cd3E14gh4P04ab8D18ab2L12gh2L04ef1M20ef5L22gh4I03gh1C15ef6J04gh2A16cd5K12ab7F11cd6N10ab3I01cd7K01cd6I17gh4E23gh1A17cd8   碱性磷酸酶；胎盘(Regan同工酶)转座子来源的Buster1转座酶样蛋白质利血平Q6coatomer蛋白质复合物；亚基γ2生长分化因子5(软骨来源的形态发生蛋白质1)CGI-152蛋白质RAB2；成员RAS癌基因家族样ADP核糖基化因子样4unc-93同系物A(线虫)甘丙肽相关肽转移相关1aminoadipate-semialdehyde脱氢酶-phosphopantetheinyl转移酶UDP-Gal：βGlcNAc β1；4-半乳糖基转移酶；多肽4ras同系物基因家族；成员D膜相关核酸结合蛋白质MAD；抗decapentaplegic母性同系物(果蝇)互作蛋白质；受体活化锚蛋白v-Ha-ras Harvey大鼠肉瘤病毒癌基因同系物1-酰基甘油-3-磷酸O-酰基转移酶2(溶血磷脂酸酰基转移酶；β)骨形态发生蛋白质3(骨原性)蛋氨酰氨肽酶2G蛋白信号19互作蛋白质1调节子bHLH因子Hes4Ty 6同系物抑制子(酿酒酵母)染色体22开放阅读框5   88.50098131.0923144.3305110.1673101.9864111.6731119.8171124.1402131.989135.6724104.9962115.3352113.705407.701896.25484113.9303129.7326264.2959107.6548144.5853204.52782.07855112.2771100.4037   16497.310911515213410614312813411810410649214622310423811795.1200213140131   124.6125124.7023124.7205124.9117124.9218124.9301124.9467125.0573125.0667125.067125.1131125.222125.2504125.2682125.3861125.3908125.3947125.4039125.4244125.4613125.5241125.5621125.5917125.6586   125.869117.695125.9829116.849126.3658123.6472116.8445130.7449128.2583131.4839116.0949114.7055115.0129341.5178122.4125154.2554119.6125209.3705116.6372121.7158176.6683140.2118125.8246119.1056   4.94E-01-7.21E-02-2.11E-011.81E-012.93E-011.62E-016.05E-021.06E-02-7.77E-02-1.17E-012.53E-011.19E-011.40E-01-1.70E+003.81E-011.38E-01-4.91E-02-1.08E+002.20E-01-2.05E-01-7.04E-016.13E-011.62E-013.24E-01   8.94E-01-4.30E-01-4.06E-016.78E-025.77E-012.67E-01-1.80E-012.04E-01-4.74E-02-2.10E-021.71E-01-1.55E-01-1.00E-012.70E-015.97E-019.72E-01-3.23E-01-1.49E-011.18E-01-6.04E-01-3.26E-021.38E+003.14E-013.87E-01   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y5J0P51687P51178Q9H8J6O95900Q9Y6N3Q07869Q9Y333Q9NPD1Q15928O43826Q9NWL0P31629O15530Q9Y2R5Q15208Q9UET6Q9H5N0Q9H019Q9Y673O75690Q9NUP6Q14296Q9NW55O43639P17544O75911Q06430Q13769Q9H864   J01ef2O16cd1A13ef6H23gh5B20ef8B01cd5C21cd1I07gh4L06gh2K06cd3I04ab4J05gh2B04ef6I10ab8L21ef4D01cd7J19gh6F15gh5B22gh4F05cd8M08gh7H22gh2C03cd7B20gh2H01cd3L08ab2M01cd5K15ef3D10cd3J14gh5   线粒体核糖体蛋白质L48亚硫酸氧化酶磷脂酶C；δ1NDRG家族成员3假定蛋白质CLONE24922氯离子通道；钙活化的；家族成员3过氧化物酶体增殖活化的受体；α染色体6开放阅读框28G蛋白偶联受体85锌指蛋白141(克隆pHZ-44)葡萄糖-6-磷酸酶；转运(葡萄糖-6-磷酸)蛋白质1假定蛋白质FLJ20758人免疫缺陷病毒I型增强子结合蛋白质23-磷酸肌醇依赖的蛋白激酶1线粒体核糖体蛋白质S17丝氨酸/苏氨酸激酶38FtsJ同系物1(大肠杆菌)染色体7开放阅读框2假定蛋白质RP1-317E23Alg5；酿酒酵母；同系物UHS KerB假定蛋白质FLJ11220FAST激酶假定蛋白质FLJ10307NCK衔接蛋白2转录激活因子7短链脱氢酶/还原酶1葡糖胺酰(N-乙酰)转移酶2；I-分枝酶染色体22开放阅读框19类似于剪接因子的假定蛋白质FLJ11021；富含精氨酸/丝氨酸4   117.4353105.2314126.4221121.7115165.640499.89597120.1031109.0761206.0578101.1559229.7084114.0453116.0174186.1234106.3741158.8765102.5266102.3349102.5329100.2543121.359895.908122.492494.73914139.9609108.5839156.365894.56995122.781297.58044   10712816219825713511211428518811112021119313620412012915013115014492.914179.6112173139121142   125.8555125.9497126.0345126.048126.0637126.1695126.2127126.2563126.2683126.2732126.3113126.3891126.4284126.45126.4713126.5253126.5378126.5687126.5974126.6884126.7819126.8164126.9021126.9877127.0293127.0848127.1125127.1541127.1547127.1909   116.7986119.5637138.0904148.4766182.738120.3564119.4872116.4501205.7432138.6304155.5451120.1186151.1911168.488122.8701163.2891116.4386119.1911126.5367119.1797132.5659122.1684114.1093120.8058115.5457115.9726152.0313120.315123.5081122.387   9.99E-022.59E-01-4.43E-035.05E-02-3.94E-013.37E-017.16E-022.11E-01-7.07E-013.20E-01-8.63E-011.48E-011.24E-01-5.58E-012.50E-01-3.28E-013.04E-013.07E-013.04E-013.38E-016.31E-024.03E-015.10E-024.23E-01-1.40E-012.27E-01-2.99E-014.27E-015.05E-023.82E-01   -1.33E-012.77E-013.56E-017.00E-016.31E-014.35E-01-9.89E-026.39E-024.67E-018.98E-01-1.05E+007.25E-028.64E-015.15E-023.52E-013.64E-012.30E-013.30E-015.53E-013.81E-013.01E-015.84E-01-3.98E-015.70E-01-8.13E-014.79E-021.43E-015.58E-01-2.60E-025.45E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O95500P14222Q9Y4C8Q9H3H5Q13433Q00059Q15119O43791Q14206Q92926Q9P288Q9NZU5Q13569P48167Q9NQR1O43405Q9P028Q9Y6E8Q9NV65Q9H0R8O95817P36956P08236Q13425Q14676P16106Q14773O14736   F06cd7P02cd2B06ef2M23ab4G05cd8O07cd2I06ab8F03cd3P10cd5N24cd1G15ef3C16ef4O13cd2D17ef6I02gh4B23ab4N24ef2P04cd7H17gh3M13gh7P02cd4K10cd2D05ab3D12cd2E18gh1O12gh6J03ab6N19gh4   claudin 14穿孔蛋白1(生孔蛋白)KIAA0682基因产物dolichyl-磷酸(UDP-N-乙酰氨基葡萄糖)N-乙酰氨基葡萄糖磷酸转移酶1(GlcNAc-1-P转移酶)LIV-1蛋白质；雌激素调节型转录因子A；线粒体丙酮酸脱氢酶激酶；同工酶2斑点型POZ蛋白质唐氏综合征判别区域基因1样1SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族d；成员3BRCA2.和CDKN1A互作蛋白质LIM和富含半胱氨酸结构域1胸腺嘧啶-DNA转葡糖基酶甘氨酸受体；β包含PR/SET结构域的蛋白质07凝血因子C同系物；cochlin(美洲鲎)CCR4-NOT转录复合物；亚基2sirtuin沉默交配型信息调节2同系物3(酿酒酵母)假定蛋白质FLJ10901GABA(A)受体相关蛋白质样1BCL2相关athanogene 3甾醇调节因子结合的转录因子1葡糖醛酸酶；βsyntrophin；β2(抗肌萎缩蛋白相关蛋白质A1；59kD；碱性组分2)KIAA0170基因产物H3组蛋白家族；成员F细胞间粘附分子4；兰-威血型推断的甲基转移酶   183.029499.11893105.4769193.8179118.096111.461597.01115111.349119.8147115.147148.9477164.143883.16502109.5501154.2185103.0764104.0341109.168492.33747122.091107.1752140.2284123.7102106.724193.4128898.02235101.85124.8741   18113514610810513113511426310513212817213992.7121133110188179114109114122145136137126   127.2815127.3674127.3803127.5134127.6623127.6629127.6675127.7061127.7164127.7503127.8623127.9349127.9545127.9738128.0258128.1793128.2089128.2444128.3243128.3386128.4319128.532128.6103128.6723128.7328128.7695128.8098128.8151   163.6478120.5243126.2296143.2265116.7563123.3486120.0132117.7111170.2393116.1179136.3262139.9549127.6936125.3664124.9651117.417121.9053115.6628136.3658143.1503116.5745125.9988122.0379119.2218122.2375120.7804122.427126.6152   -5.24E-013.62E-012.72E-01-6.04E-011.12E-011.96E-013.96E-011.98E-019.21E-021.50E-01-2.20E-01-3.60E-016.22E-012.24E-01-2.69E-013.14E-013.01E-012.32E-014.75E-017.20E-022.61E-01-1.26E-015.60E-022.70E-014.63E-013.94E-013.39E-014.48E-02   -1.90E-024.47E-014.67E-01-8.39E-01-1.76E-012.32E-014.81E-013.49E-021.14E+00-1.27E-01-1.72E-01-3.61E-011.05E+003.39E-01-7.35E-012.31E-013.59E-015.37E-031.03E+005.52E-019.05E-02-3.60E-01-1.21E-011.96E-016.30E-014.68E-014.24E-011.47E-02   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y297Q13585O60858Q9Y2Z6Q9UG66Q9Y6G5P98155Q9NP50P28328Q969T4P19827O15096Q9Y5J6Q92889P08697Q9UBX1Q9NPI7P11586O96010Q13188Q13845Q9Y5W9O60539O60885Q9H2B0P51582   N21cd4H16cd4L24cd5E06ef2P16ef7N17ef2E06cd3C07gh5C01ab8M24cd6D18ab6M18ab8J16cd7M24ab4C07ef1A05cd4D22ef1D14ef7J15cd4P13cd2I21ab3D07cd8I02cd7I02ef3O16gh5C24ab8   包含β转导素重复G蛋白偶联受体50ret指蛋白2CGI-07蛋白质假定蛋白质DKFZp586G0123PTD002蛋白质极低密度脂蛋白受体TERA蛋白质过氧化物酶体膜蛋白质3(35kD；脑-肝-肾综合征)泛素缀合酶E2E 3(UBC4/5同系物；酵母)中间α(球蛋白)抑制剂；H1多肽磷脂酰肌醇4-激酶；催化型；β多肽骨折愈伤组织1同系物(大鼠)切除修复交叉互补啮齿类修复缺陷；互补组4丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade F(α-2抗血纤维蛋白酶；色素上皮源性因子)；成员2组织蛋白酶F假定蛋白质LOC51315亚甲基四氢叶酸脱氢酶(NADP+依赖性)；次甲基四氢叶酸环水解酶；甲酰四氢叶酸合成酶结合LIM结构域1丝氨酸/苏氨酸激酶3(STE20同系物；酵母)B-细胞CLL/淋巴瘤7B分选连接蛋白11Ras相关(RalGDS/AF-6)结构域家族1包含bromodomain的4核小体装配蛋白质1样1嘧啶受体P2Y；G蛋白偶联；4   152.2864121.9424110.164396.22816318.3297107.7937113.136594.63638321.6292117.2071239.4455117.2574102.357157.5735138.5253113.4065240.5378141.245690.9506117.4664145.9359144.6605126.8466114.9928122.5782116.4263   14211311013937414110419921910018611512797.613611817110615513588.319810298.1147109   128.8641128.8853128.8939128.9272128.9795129.1324129.1355129.2792129.3474129.3512129.3613129.4365129.4503129.5255129.5425129.6557129.76129.8444129.8567129.8809129.9273130.0152130.0346130.1093130.1112130.158   141.0555121.1757116.2529121.3443273.7118125.8408115.483140.8474223.2274115.6428185.0551120.4316119.4401128.238134.8048120.4495180.4148125.7751125.1912127.4091121.3988157.7019119.7412114.4111133.1825118.649   -2.41E-017.99E-022.27E-014.22E-01-1.30E+002.61E-011.91E-014.50E-01-1.31E+001.42E-01-8.88E-011.43E-013.39E-01-2.83E-01-9.67E-021.93E-01-8.90E-01-1.21E-015.14E-011.45E-01-1.68E-01-1.54E-013.58E-021.78E-018.60E-021.61E-01   -1.01E-01-1.14E-01-6.09E-035.29E-012.32E-013.83E-01-1.19E-011.07E+00-5.56E-01-2.24E-01-3.62E-01-3.31E-023.06E-01-6.91E-01-2.29E-026.08E-02-4.93E-01-4.11E-017.67E-011.99E-01-7.24E-014.56E-01-3.10E-01-2.29E-012.61E-01-9.03E-02   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O00585Q15131O75148Q15691Q15779Q9UHD2Q9NSS3Q13797P46531O43262Q9Y2H6P25788Q9BQS8Q9Y396Q9P0R7O15269Q9UFX0Q9H663O75410Q9Y5N5Q9BQ72Q9Y303Q9P005Q9Y3A1Q15172Q9BV19   F08cd1B23ef5F08cd8G17cd8H21ab8K14cd8K15gh3I01ef7M10ef5C01cd6K12ef8J11ab8D09gh7J04ef1K06ef2F17cd6B02ef2F24gh5P17cd2I14cd8F02gh7E10ef2A22ef8H19ef2C12cd1I19gh6  可诱导小细胞因子亚家族A(Cys-Cvs)；成员21细胞周期蛋白依赖性蛋白激酶(CDC2-样)10隐花色素2(光裂合酶样)微管相关蛋白；RP/EB家族；成员1前胶原(III型)N-内肽酶TANK-结合激酶1假定蛋白质DKFZp434E2220整联蛋白；α9Notch同系物1；易位相关(果蝇)淋巴细胞性白血病缺失；2KIAA0970蛋白质蛋白酶体(前体；macropain)亚基；α型；3包含FYVE和卷曲螺旋结构域1延伸极长链脂肪酸(FEN1/EIo2；SUR4/EIo3；酵母)-样1假定蛋白质LOC51242丝氨酸软脂酰转移酶；长链碱性亚基1钙结合特应性相关自身抗原1小鼠肌动蛋白相关蛋白质8同系物的可能性直向同源物(酿酒酵母)转化；酸性包含卷曲螺旋的蛋白质1推断的N6-DNA-甲基转移酶假定蛋白质MGC10471CGI-14蛋白质HSPC159蛋白质DKFZP564O084蛋白质蛋白质磷酸酶2；调节亚基B(B56)；α同工型假定蛋白质MGC955   168.745168.610486.14249173.7024141.440882.31867107.5389156.994686.0196376.79463170.8655258.6025164.6348162.6431126.730297.42808233.508998.1679224.118899.34841106.3824153.5787341.3083200.4927168.391496.47316   2161081721681331721158516419512828520782.2218133287128133133115101579262140141   130.1849130.2201130.27130.2758130.2905130.2947130.3095130.4752130.4897130.4943130.5238130.5899130.6451130.6722130.6804130.7429130.8943130.9258130.9827131.0924131.1126131.2035131.3146131.514131.5524131.6188   171.5056135.7223129.5265157.4437135.0227128.1679117.5518124.1726126.8111134.2594142.9858224.7239167.5571125.1558158.5209120.3129217.1357119.1698162.703121.2285117.4135128.5162350.7027198.1031146.553122.8739   -3.74E-01-3.73E-015.97E-01-4.15E-01-1.18E-016.62E-012.77E-01-2.67E-016.01E-017.65E-01-3.89E-01-9.86E-01-3.34E-01-3.16E-014.43E-024.24E-01-8.35E-014.15E-01-7.75E-014.00E-013.02E-01-2.27E-01-1.38E+00-6.08E-01-3.56E-014.48E-01   3.53E-01-6.38E-019.99E-01-4.51E-02-8.51E-021.06E+009.44E-02-8.84E-019.30E-011.35E+00-4.22E-011.40E-013.33E-01-9.85E-017.84E-014.46E-012.98E-013.87E-01-7.53E-014.24E-011.09E-01-6.08E-017.64E-013.88E-01-2.69E-015.43E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q14534Q9BS43P49788Q9UP83Q9Y2X0Q9Y3E3O95183Q13242Q9Y5R5P04181Q14254Q9Y6E6Q9H237Q92785O95458P20749Q9H2N8Q15020P42025P98173O95295Q9NVA1P35573Q13126P43034Q01844P27482Q9NUW4P78552   E11cd2G19gh8D24ab8M10cd6N11cd5I15ef2J14cd6N22cd3A06gh1N02ab7B15ab4P08cd7D20gh5N21cd2N11cd2P23ef6D24gh7M08gh1O01gh1I23gh5C06cd8F15gh3O03ab2K13ab7C11ab8E15ab5E18ab6N23gh3J23ab6   鲨烯环氧酶假定蛋白质MGC12435视黄酸受体反应物(tazarotene诱导的)1寡聚高尔基复合物组分5甲状腺激素受体相关蛋白质；95-kD亚基CGI-145蛋白质小泡相关膜蛋白质5(myobrevin)剪接因子；富含精氨酸/丝氨酸9双性及mab-3相关转录因子2鸟氨酸转氨酶(回旋形萎缩)flotillin 2sirtuin沉默交配型信息调节2同系物5(酿酒酵母)porcupinerequiem；凋亡反应性锌指基因微管蛋白特异性分子伴侣dB-细胞CLL/淋巴瘤3假定蛋白质GL012T细胞识别的鳞状细胞癌抗原3ARP1肌动蛋白相关蛋白质1同系物B；中心体肌动蛋白β(酵母)2.19基因SNARE相关蛋白质snapin染色体20开放阅读框44淀粉-1，6-葡萄糖苷酶；4-α-葡聚糖转移酶(糖原脱支酶；糖原贮积病III型)甲基硫腺苷磷酸化酶血小板活化因子乙酰水解酶；同工型Ib；α亚基(45kD)尤因肉瘤断裂点区1钙调蛋白样3BRIX白细胞介素13受体；α1   155.5799592.169497.19637100.2446116.898294.7673391.19765156.0624100.8446112.3954130.158694.40989148.2204118.3718128.9522264.1174104.3233117.2757243.7979113.0426324.3312111.7508111.9583202.8169106.8174111.2628114.7017223.8591118.2476   71.312113514197.91321571411621061541362581081001861601479211611910010623612510210477.193.9   131.8107131.9022131.9355131.936131.9541131.9919132.0539132.0637132.1528132.1687132.2038132.2501132.2656132.3893132.4761132.484132.5137132.5393132.554132.6703132.6986132.7232132.7432132.9211132.987133.001133.018133.0208133.0765   119.574281.8569121.3412124.3058115.5741119.5355126.6473143.0016131.5571116.724138.6301121.0265179.3923119.7533120.4814194.2507132.1507132.2727156.1129120.727192.0882114.8529116.8065190.4847121.4511115.5021117.2725144.6673115.0749   -2.39E-01-2.17E+004.41E-013.96E-011.75E-014.78E-015.34E-01-2.41E-013.90E-012.34E-012.25E-024.86E-01-1.64E-011.61E-013.89E-02-9.95E-013.45E-011.77E-01-8.79E-012.31E-01-1.29E+002.48E-012.46E-01-6.10E-013.16E-012.57E-012.14E-01-7.51E-011.70E-01   -1.13E+00-2.29E+004.73E-014.89E-01-2.56E-014.76E-017.81E-01-1.48E-016.81E-01-8.99E-022.38E-015.31E-017.98E-01-1.26E-01-3.67E-01-5.05E-016.14E-013.26E-01-1.41E+004.31E-02-1.44E+00-1.59E-01-8.27E-022.17E-012.22E-01-1.22E-01-1.40E-01-1.54E+00-3.33E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P51843P15822Q9BXY9Q9ULB4Q9NZZ7Q02086Q9BUV9Q9UHJ9Q16401Q9Y4K4O60463O95639P50539Q9UH62O15525Q9H8T0Q9Y4X5Q9H9E1Q93063Q9H992O43237Q99643P24386Q9Y5F7P06756Q9H5L7   O24ab2L23ab5O13gh8P10ef1C08ef8C09cd2H14gh6A09ef4E11cd1D04cd6H06cd3P20cd6N19ab7I15ef3C13ab7H21gh5K03cd6O01gh5F13ab3D22gh5P02ab4H02cd1F11ef1F12gh4D14ab6C02gh6   核受体亚家族0；B组；成员1人免疫缺陷病毒I型增强子结合蛋白质1包含RALBP1相关Eps结构域1钙粘蛋白9；2型(T1-钙粘蛋白)HSPC171蛋白质Sp2转录因子DKFZP586J0119蛋白质FGF受体活化蛋白质1蛋白酶体(前体；macropain)26S亚基；非ATP酶；5促分裂原活化蛋白激酶激酶激酶激酶5磷脂酸磷酸酶2A型断裂及聚腺苷酸化特异性因子4；30kD亚基MAX互作蛋白质1ALEX3蛋白质v-maf肌腱膜纤维肉瘤癌基因同系物G(鸟类)融合的toes同系物(小鼠)ariadne同系物；泛素缀合酶E2结合蛋白质；1(果蝇)锚蛋白重复序列；家族A(RFXANK-样)；2exostoses(多发性)2axotrophin动力蛋白；细胞质部分；轻链中间体多肽2琥珀酸脱氢酶复合物；亚基C；膜内在蛋白质；15kD无脉络膜(Rab escort蛋白质1)原钙粘蛋白γ亚家族C；4整联蛋白；αV(玻璃粘附蛋白受体；α多肽；抗原CD51)染色体1开放阅读框28   104.732983.2694290.84238275.2974214.9523101.0989102.1174100.7903143.6091132.4072103.2417183.1762175.6646118.2527105.3252106.214599.46477172.6266123.288689.54768290.6769143.447493.86058101.7878200.0782173.8106   11216014013726513311912112015815167.618717110924112878.8161149119125129114219148   133.1401133.2118133.274133.4641133.5412133.5465133.5923133.6008133.6156133.6676133.6898133.7241133.7304133.7314133.7521133.7606133.8771134.052134.3466134.4784134.4914134.5527134.5538134.5585134.6115134.6601   116.7757125.3978121.2561181.8847204.594122.3826118.2651118.5627132.2946141.2069129.2479128.1539165.4016140.9912116.1167160.2791120.4976128.4841139.4501124.4411181.4903134.443119.0446116.632184.6891152.0822   3.46E-016.78E-015.53E-01-1.04E+00-6.87E-014.02E-013.88E-014.07E-01-1.04E-011.37E-023.73E-01-4.54E-01-3.93E-011.77E-013.45E-013.33E-014.29E-01-3.65E-011.24E-015.87E-01-1.11E+00-9.24E-025.20E-014.03E-01-5.72E-01-3.68E-01   1.03E-019.40E-016.20E-01-1.01E+003.04E-013.90E-012.22E-012.67E-01-2.63E-012.51E-015.47E-01-1.44E+008.87E-025.32E-015.31E-021.18E+003.66E-01-1.13E+003.82E-017.37E-01-1.28E+00-1.95E-014.56E-011.58E-011.33E-01-2.34E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O15517Q9P0N5Q9NWT2Q9Y2A0Q9NZ43P27986Q9UBP6Q9BWK5P54802O75963Q9NXZ4O60353Q9NQS6O14776Q9Y5A2P49842Q06546Q9Y2E7Q9UM11Q99447Q9H1R3P28358O76070Q9Y5A7Q9NWY7O43715Q9BY75O43431   A14ef6K24ef2D19gh2O02cd7N16gh4A10ef1J13ef1P24gh5M24ab6H09cd7F03ef4B11cd3F13gh4A19cd7L13ef1G23cd6J14ab5I02ef8I02ef2B14ab8F22gh8P05ab6P18cd1N07ef2A16gh3P02ef2K19gh8A12ef7   肿瘤坏死因子受体超家族；成员10bHSPC244假定蛋白质FLJ20623TP53靶基因1非特征性造血干/祖细胞蛋白质MDS032磷酸肌醇-3-激酶；调节亚基；多肽1(p85α)甲基转移酶样1假定蛋白质MGC5242N-乙酰葡糖胺糖苷酶；α-(Sanfilippo病IIIB)G蛋白偶联受体ELG蛋白质卷曲同系物6(果蝇)latexin蛋白质转录延伸因子1(CA150)推断的锌指蛋白质NY-REN-34抗原丝氨酸/苏氨酸激酶19GA结合蛋白质转录因子；α亚基(60kD)KIAA0938蛋白质Fzr1蛋白质磷酸胞苷酰转移酶2；乙醇胺肌球蛋白轻链激酶2；骨骼肌同源异形盒D10synuclein；γ(乳腺癌特异性蛋白质1)NEDD8 ultimate buster-1假定蛋白质FLJ20530假定蛋白质HSPC132itchy同系物E3泛素连接酶(小鼠)内皮细胞分化；溶血磷脂酸G蛋白偶联受体；4   92.33364107.9991107.8864127.408141.2528111.3806107.2187101.1324206.038110.3886124.520585.6491894.21822113.3803154.0704133.355788.93312109.821880.82847174.820193.58977108.9905128.551119.0653103.7638137.4694118.5721126.4659   20712910588.213711212212366.318410514616311718617113810518677.4129102140195110110127171   134.6603134.6618134.7112134.8491134.9524134.9586134.986134.9881135.077135.3412135.3934135.5169135.5761135.6603135.6708135.7013135.7488135.7763135.8949135.988136.0456136.1419136.1645136.2606136.3026136.3043136.5094136.5393   144.7566123.7736115.8334116.8334137.7883119.3503121.358119.8654135.7965143.3711121.5448122.5147130.917122.1137158.5684146.5953120.885116.739134.12129.39119.5324115.6766134.744149.951116.6328127.9562127.3323144.6131   5.44E-013.18E-013.20E-018.19E-02-6.58E-022.77E-013.32E-014.17E-01-6.09E-012.94E-011.21E-016.62E-015.25E-012.59E-01-1.83E-012.52E-026.10E-013.06E-017.50E-01-3.62E-015.40E-013.21E-018.30E-021.95E-013.94E-01-1.23E-022.03E-011.11E-01   1.17E+002.53E-01-4.05E-02-5.30E-01-4.24E-024.28E-031.85E-012.88E-01-1.64E+007.40E-01-2.50E-017.73E-017.90E-014.90E-022.71E-013.56E-016.34E-01-7.00E-021.20E+00-1.18E+004.63E-01-9.71E-021.18E-017.08E-018.20E-02-3.20E-019.81E-024.34E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O43567Q9Y2S7O14582O75056Q9P2Y2Q16595Q14807Q9BZL4P30876Q9UGP6P52655Q9HB07Q92940Q9NWN1O43664O14647O75333Q16539Q9NQG5Q15149Q9NVZ7Q15800Q9H0B6P09001O00301P55786Q9Y5Y9   D15cd7P13ef8O24ef2G12gh1D18gh4M08ab3B18ab7L10gh6I13ab8B17cd7M01ef2G23gh5H23ab7H19gh2A10cd6C19ab4N15cd2J04ef5A07gh5E05ab8G12gh3D02cd2D16gh5K14cd7D24cd3J19ef7B14cd2  环指蛋白13DKFZP586F1524蛋白质脊椎骨骺发育不良；晚期；假基因多配体聚糖3(N-多配体聚糖)β-1；4甘露糖酰转移酶弗里德赖希共济失调驱动蛋白样4蛋白磷酸酶1；调节(抑制剂)亚基12C聚合酶(RNA)II(DNA指导的)多肽B(140kD)coatomer蛋白质复合物；亚基ε普通转录因子IIA；1(37kD和19kD亚基)染色体12开放阅读框10MAD；母抗decapentaplegic同系物3(果蝇)假定蛋白质FLJ20727G蛋白偶联受体66染色质域解旋酶DNA结合蛋白质2T-盒10促分裂原活化蛋白激酶14染色体20开放阅读框77网蛋白1；中间丝结合蛋白质；500kD假定蛋白质FLJ10407甾醇-C4-甲基氧化酶样类似于驱动蛋白轻链的假定蛋白质FLJ12387线粒体核糖体蛋白质L3KH型剪接调节蛋白质(FUSE结合蛋白质2)嘌呤霉素敏感性氨肽酶钠道；电压门；X型；α多肽   110.4449113.1366135.1666120.066189.6857139.5657114.4726110.5367265.533794.73601121.4896121.2547414.4889117.7514108.131196.14904126.0065148.733986.80552125.7248166.213171.864896.5494394.17331126.0509273.7328127.3727   15310413516214313094.212320013412811822312010216412921914383.917571.212912888.398.9139   136.5722136.7041136.7342136.797136.8208136.8314136.9298137.0777137.1153137.3091137.3707137.4723137.6028137.6351137.6789137.7441137.7737137.8137.803138.0785138.1444138.1497138.1542138.1601138.3014138.3924138.4331   133.3964117.8414135.7349139.562123.2251135.5917115.2048123.5234200.7168122.0845129.1154125.5248258.3032124.9938116.0604132.5407130.9257168.4312122.4598115.8848159.6342127.0641121.3672120.1502117.5428170.346134.9928   3.06E-012.73E-011.66E-021.88E-016.09E-01-2.85E-022.58E-013.10E-01-9.54E-015.35E-011.77E-011.81E-01-1.59E+002.25E-013.49E-015.19E-011.29E-01-1.10E-016.67E-011.35E-01-2.67E-01-3.15E-015.17E-015.53E-011.34E-01-9.84E-011.20E-01   4.72E-01-1.26E-011.46E-034.31E-016.75E-01-9.82E-02-2.81E-011.54E-01-4.12E-015.02E-018.08E-02-4.11E-02-8.95E-012.24E-02-7.90E-027.68E-013.38E-025.57E-017.18E-01-5.84E-017.06E-02-1.27E+004.22E-014.44E-01-5.14E-01-1.47E+001.28E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P19235O15228Q9UK97P50990Q9NZM1Q92924O75845Q9NQ88Q16515P49759P33552O75808Q9NXR1O75381O60930O14653Q16540O14658Q15814Q9Y3C9P18827P04150Q9Y301O00626Q9Y311Q15633   M01ef7A16ef3K05cd8D20cd6P19cd8N20cd1A18gh1I10gh4C19ab2F16ab5A22ab5H21cd2M07gh2L12ab8P23cd1P14cd4L24gh1P06cd2M17cd2J09ef2F22cd1B21ab3N05ef1F10cd1B18cd8C01ef2K14cd2   红细胞生成素受体磷酸甘油酮O-酰基转移酶仅有F-盒的蛋白质9包含伴侣蛋白的TCP1；亚基8(θ)fer-1样3；myoferlin(线虫)SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族d；成员1甾醇-C5-去饱和酶(ERG3δ-5-去饱和酶同系物；真菌)样染色体12开放阅读框5amiloride敏感性阳离子通道1；神经元(退化蛋白)CDC样激酶1CDC28蛋白质激酶2小视叶同系物(果蝇)LIS1互作蛋白质NUDE1；大鼠同系物过氧化物酶体生源因子14核糖核酸酶H1高尔基SNAP受体复合物成员2线粒体核糖体蛋白质L23ras相关C3肉毒杆菌毒素底物3(rho家族；GTP结合小蛋白质Rac3)微管蛋白特异性分子伴侣cCGI-127蛋白质多配体聚糖1核受体亚家族3；C组；成员1CGI-12蛋白质可诱导小细胞因子亚家族A(Cys-Cvs)；成员22神经前体细胞表达的；发育下调的1线粒体核糖体蛋白质L2TAR(HIV)RNA结合蛋白质2   198.5954225.1315151.0501274.982218.8411131.7669101.928580.2401102.115986.24615109.5671115.65496.20481473.8395167.3611115.7917209.2433158.176103.369983.4762114.4045106.6921108.0511113.478108.1711162.8519169.3779   77.318610417820282.71531581091479698.912311311189.712016611216392.710310110613374.8125   138.4803138.5137138.5593138.6001138.6209138.6764138.7232138.8274138.9915139.0985139.1297139.1625139.1939139.2209139.2393139.2541139.3426139.3634139.6311139.6599139.6607139.6889139.7035139.8189139.9597139.9856140.0138   138.1099183.349131.097197.1593186.4122117.704131.1196125.605116.6136124.2553114.8881117.8898119.5057241.8793139.1464114.9152156.1365154.6374118.2869128.8568115.5895116.6017116.3594119.8588127.048125.8788144.9588   -5.20E-01-7.01E-01-1.25E-01-9.88E-01-6.59E-017.37E-024.45E-017.91E-014.45E-016.90E-013.45E-012.67E-015.33E-01-1.77E+00-2.65E-012.66E-01-5.87E-01-1.83E-014.34E-017.42E-012.88E-013.89E-013.71E-013.01E-013.72E-01-2.18E-01-2.75E-01   -1.36E+00-2.72E-01-5.43E-01-6.28E-01-1.17E-01-6.73E-015.83E-019.75E-019.06E-027.73E-01-1.91E-01-2.26E-013.56E-01-2.07E+00-5.95E-01-3.68E-01-8.04E-017.29E-021.14E-019.69E-01-3.03E-01-4.49E-02-9.27E-02-9.45E-022.98E-01-1.12E+00-4.33E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P02278P53672P09417Q9HAY2P30273Q92949Q9GZT9P35658Q9HB40O14686Q92911Q9Y5E4Q13057Q14863P36610O60240Q9H9B4O00584Q9H658P18858Q02877P15586P42696O75710Q9NPI8Q9HAR6P15018Q13546P24298Q14129   M22gh6J11cd7C05ab8K14gh5A20ab5G10ab4G01gh7O23cd4G01gh5O16cd3O12cd1B18ef3H17gh7B23ab8G10ef3O12ab8P05gh5J14cd3M04gh7K14ef6D23cd1J07ab4H08ef4A17ef1C01gh2O10gh5O18ef7A23cd4H01ab4C22cd4   H2B组蛋白家族；成员K晶体蛋白；βA2醌式二氢喋啶还原酶MAGEF1蛋白质IgE的Fc片段；高亲和力I；受体；γ多肽forkhead盒J1egl 9同系物1(线虫)核孔蛋白214kD(CAIN)大鼠和小鼠视黄醇可诱导的丝氨酸羧肽酶的可能同系物骨髓/淋巴或混合性白血病2溶质载体家族5(碘化钠转运蛋白)；成员5原钙粘蛋白β5核苷酸结合蛋白质POU结构域；6类；转录因子1frequenin同系物(果蝇)perilipin假定蛋白质FLJ12876核糖核酸酶6前体G蛋白偶联受体107连接酶I；DNA；ATP依赖性核糖体蛋白质L26葡糖胺(N-乙酰)-6-硫酸酯酶(Sanfilippo病IIID)KIAA0117蛋白质钼辅因子合成1范科尼贫血；互补组F子宫来源的14kDa蛋白质白血病抑制因子(胆碱能分化因子)受体(TNFRSF)互作丝氨酸-苏氨酸激酶1谷丙转氨酶(丙氨酸转氨酶)DiGeorge综合征临界区域基因6   100.2794101.7321126.636196.0167588.48289250.4112112.8025141.8279105.9316117.844264.125695.08061186.8796103.2077110.21911121.10887.99841124.6932158.259592.33071449.1728261.466110.9202105.3087193.8104118.9551253.8099139.7074210.426112.1253   21618716112617116799.213799.315712514812510313652.213325021412829711923110121419830913197.1141   140.0965140.2804140.3564140.3654140.4541140.5084140.6556140.7761140.9548141.0674141.0904141.1894141.2202141.3258141.4925141.5046141.7125141.8008141.8139141.8761141.8851141.968141.9948142.0352142.0643142.0669142.2733142.2746142.3123142.4302   152.2309142.8494142.5395120.9341133.3475185.89117.5626139.8811115.3964138.5398176.594127.9379151.0906115.7954129.0874438.2653120.8973172.0542171.1973120.8853295.8854174.2861161.4649116.2449183.3737152.8734235.0602137.7012149.9584131.8973   4.82E-014.64E-011.48E-015.48E-016.67E-01-8.34E-013.18E-01-1.07E-024.12E-012.60E-01-9.05E-015.70E-01-4.04E-014.53E-013.60E-01-2.99E+006.87E-011.85E-01-1.58E-016.20E-01-1.66E+00-8.81E-013.56E-014.32E-01-4.48E-012.56E-01-8.35E-012.63E-02-5.64E-013.45E-01   1.11E+008.75E-013.43E-013.97E-019.51E-01-5.87E-01-1.85E-01-4.96E-02-9.32E-024.11E-01-1.08E+006.34E-01-5.78E-01-4.97E-032.98E-01-4.43E+005.96E-011.00E+004.32E-014.76E-01-5.99E-01-1.13E+001.06E+00-5.47E-021.45E-017.32E-012.84E-01-9.15E-02-1.12E+003.32E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9BQA2Q9UJX9Q99590O14798P32238Q9UQ90P82980P49716P20062P21580Q99774Q9P0T1P06737O15063P02743Q9NVT0Q9Y4P3Q13886Q9NVP8P08240P49459Q9NVA8P25325Q9UHI6P52298Q9NQ30O00541Q9H2V9   K09gh8B12ef3I01cd5C06ef7P01ab3C17cd2M03gh8P15ab5M12cd1B06cd2H01cd5A17ef3B18ab8K10gh1K14ab2I14gh3O07ef3N14ab3L19gh4G05cd2M19ef5L16gh2K23cd3K08cd7H01cd7A10cd7I08ef3B06gh7   KIAA1882蛋白质假定蛋白质；雌二醇诱导剪接因子；富含精氨酸/丝氨酸2；互作蛋白质肿瘤坏死因子受体超家族；成员10c；无细胞内结构域的诱饵胆囊收缩素A受体痉挛性截瘫7；半身不遂(纯净而复杂的常染色体隐性)视黄醇结合蛋白5；细胞的CCAAT/增强子结合蛋白质(C/EBP)；δ钴胺素传递蛋白II；大红细胞性贫血肿瘤坏死因子；α诱导蛋白质3蛋白磷酸酶4；调节亚基1假定蛋白质HSPC192磷酸化酶；糖原；肝(Hers病；糖原贮积症VI型)KIAA0355基因产物淀粉样P物质；血清假定蛋白质FLJ10534转导素(β)样2碱性转录元件结合蛋白质1假定蛋白质FLJ10595信号识别颗粒受体(′停靠蛋白质′)泛素缀合酶E2A(RAD6同系物)溶质载体家族38；成员2巯基丙酮酸硫转移酶DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽20；103kD核帽结合蛋白质亚基2；20kD内皮细胞特异性分子1pescadillo同系物1；包含BRCT结构域(斑马鱼)假定蛋白质CDA08   164.9357121.7396231.0328142.6951487.368101.2857111.2191169.1889125.6347275.8225195.85104.436385.14818149.9191108.0152136.4264112.0852164.4049101.7956158.356598.6462112.6488288.1435135.6699138.9223104.1846180.43173.5608   18798.519921316814693.973.414131717310113914494.710910488.7106132170127274209191122204169   142.4325142.5053142.5273142.5294142.5911142.6321142.6923142.8277142.8402142.8664143.1867143.2517143.2732143.2945143.3031143.3056143.4853143.5269143.5829143.6823143.74143.7595143.8077143.8383143.8819143.9703144.0988144.1057   164.7437120.9085190.7413166.073265.9537129.9052115.9454128.4871136.6279245.0939170.7835116.1881122.6343145.705115.3343129.6057119.7013132.2194117.1232144.5673137.6267127.9498235.1972162.7208157.996123.2921176.2086162.3327   -2.12E-012.27E-01-6.97E-01-1.68E-03-1.77E+004.94E-013.60E-01-2.44E-011.85E-01-9.49E-01-4.52E-014.56E-017.51E-01-6.52E-024.08E-017.10E-023.56E-01-1.96E-014.96E-01-1.40E-015.43E-013.52E-01-1.00E+008.43E-025.06E-024.67E-01-3.24E-01-2.68E-01   1.80E-01-3.06E-01-2.18E-015.78E-01-1.54E+005.26E-01-2.44E-01-1.20E+001.71E-011.99E-01-1.76E-01-5.00E-027.12E-01-5.91E-02-1.90E-01-3.23E-01-1.14E-01-8.90E-015.83E-02-2.66E-017.89E-011.78E-01-7.45E-026.21E-014.61E-012.24E-011.78E-01-3.56E-02   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NNX1Q13508Q9NR30Q14320Q04726P20061Q9Y2Y1P35754Q02978O95792Q13232Q9NVH2Q15561Q9UPN9Q14353Q9NZM5O43255Q14331P18847O60258P47929P35227Q15599Q9UKJ5Q9HCB9Q9Y3A0   F12gh1H14ab2B21gh6E15cd5D03cd2N13cd1J12ef2G22ab5F01cd3N20gh2D20ef7L01ef8O15cd2B01ef2O06ab3A18ef4B11cd2G04ab5N23ab5I07cd4P02ab6O14cd4O15cd5B20cd7C10gh5K07ef2   tuftelin 1ADP核糖基转移酶3DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽21X染色体上DNA片段(唯一)9928表达序列split 3的转导素样增强子(E(sp1)同系物；果蝇)钴胺素传递蛋白I(维生素B12结合蛋白质；R结合物家族)聚合酶(RNA)III(DNA指导的)多肽K(12.3kD)谷氧还蛋白(巯醇转移酶)溶质载体家族25(线粒体载体；酮戊二酸载体)；成员11PRK1相关蛋白质非转移细胞3；其中表达的蛋白质DKFZP434B168蛋白质TEA结构域家族成员4包含三元基序的33胍乙酸N-甲基转移酶神经胶质瘤肿瘤抑制候选区基因2七缺席同系物2(果蝇)FSHD区基因1转录激活因子3成纤维细胞生长因子17凝集素；结合半乳糖苷；可溶；7(半乳凝素7)锌指蛋白144(Mel-18)溶质载体蛋白家族9(钠/氢交换物)；同工型3调节因子2富含半胱氨酸的疏水性结构域2染色体1开放阅读框24CGI-92蛋白质   147.0323109.4052110.4836102.5057211.8773117.3445153.7426153.823106.877130.691490.7906117.6587234.306110.9269109.1385150.098114.6318164.0964127.5442159.7671151.1595108.2295168.9673184.471794.16759119.1033   17510113017811585.514513898.214615691.217213510312210117615422392.815180.5206126178   144.106144.1545144.2348144.2677144.3217144.4835144.5561144.7308144.7822144.7909144.8861144.9821145.3307145.3321145.3798145.587145.653145.6576145.6654145.6821145.699145.8554145.993145.9967146.1683146.1698   155.2699118.095128.2929141.6929156.9544115.787147.7222145.4287116.628140.5872130.592117.932183.8604130.2668119.1987139.1802120.4593161.7807142.5299176.0472129.8767135.0089131.8082178.8637122.1779147.7783   -2.90E-023.98E-013.85E-014.93E-01-5.54E-013.00E-01-8.89E-02-8.79E-024.38E-011.48E-016.74E-013.01E-01-6.89E-013.90E-014.14E-01-4.40E-023.46E-01-1.72E-011.92E-01-1.33E-01-5.31E-024.30E-01-2.11E-01-3.37E-016.34E-012.95E-01   2.49E-01-1.19E-012.36E-017.99E-01-8.86E-01-4.56E-01-8.58E-02-1.59E-01-1.22E-011.63E-017.82E-01-3.68E-01-4.46E-012.78E-01-8.24E-02-3.01E-01-1.81E-019.77E-022.75E-014.79E-01-7.04E-014.80E-01-1.07E+001.60E-014.22E-015.80E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P49815P25116O75829Q9NYI1P24347O43189Q9P029Q9NZP9Q9UIA3Q99734O00411P28347Q13619O94929Q9P026P28067Q14126Q14267P55197Q9NP87P04155Q9C069P12270Q9UIG6O15453Q9UNW8P06746O15414   M17ef6L19ab4O01cd7M16ef2I24ef5K24ab8N22ef2E17ef2I12ef2M12ef5C19cd1P04gh1G19gh1O06ef8A02ef8D08ab5E11ef7P01cd1H09ab2O20cd8A04cd2N02gh7G14cd2I14ef2P08cd5F17cd8I10ef6I08cd7   结节性硬化症2凝血因子II(凝血酶)受体软骨调节因子I前体ECSIT基质金属蛋白酶11(基质溶素3)PHD指形蛋白1TH1样(果蝇)即早期反应5中性鞘磷脂酶Notch同系物2(果蝇)聚合酶(RNA)线粒体(DNA指导的)TEA结构域家族成员1(SV40转录增强因子)cullin 4AKIAA0843蛋白质HSPC134蛋白质主要组织相容性复合物；II类；DMα桥粒核心糖蛋白2调节因子X；4(影响HLA II类表达)骨髓/淋巴或混合性白血病(三空腔同系物；果蝇)；已易位到；10聚合酶(DNA指导的)；μ三叶因子1(乳腺癌；其中表达雌激素可诱导序列)sec13样蛋白质已易位启动子区(以活化MET癌基因)溶血磷脂酸磷酸酶LPAPNBR2G蛋白偶联受体聚合酶(DNA指导的)；β包含三核苷酸串联重复4   106.015982.48228121.7658111.792697.57916112.1101201.2292105.1683165.6408220.4251120.5078230.2101153.1592108.7821115.4895128.7098426.8387127.7912160.668115.1765258.05852.65015104.4493218.310699.08545239.3255142.5013131.6219   16314311911013610115915714726310517421899.418410036698.918586.7136424136325108347225199   146.2712146.2742146.4876146.6345146.649146.6925146.6998146.761146.8134147.0111147.0481147.0913147.2043147.2921147.3205147.3934147.4196147.4351147.4439147.4845147.487147.5255147.7447147.8779147.9143148.021148.0351148.0947   138.4231123.8585128.9495122.8588126.9018120.038168.9188136.3041153.0756210.2011124.1084183.776172.6621118.4779149.0331125.4983313.3393124.7021164.3164116.4497180.4791207.9658129.4065230.2685118.2765244.7569171.8166159.7305   4.64E-018.27E-012.67E-013.91E-015.88E-013.88E-01-4.56E-014.81E-01-1.74E-01-5.84E-012.87E-01-6.46E-01-5.72E-024.37E-013.51E-011.96E-01-1.53E+002.06E-01-1.24E-013.57E-01-8.07E-011.49E+005.00E-01-5.62E-015.78E-01-6.93E-015.50E-021.70E-01   6.20E-017.92E-01-3.81E-02-2.14E-024.84E-01-1.46E-01-3.41E-015.78E-01-1.74E-012.56E-01-2.02E-01-4.04E-015.07E-01-1.31E-016.74E-01-3.58E-01-2.23E-01-3.70E-012.02E-01-4.10E-01-9.25E-013.01E+003.81E-015.72E-011.22E-015.36E-016.58E-016.00E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O15259Q9NRA8Q9NP77Q06587Q9Y5Z5O15327P49646Q99809Q9UBM1P16403O75503P15814Q03164Q13624Q14118Q13286Q9Y5Q0Q9P0R1P41182O75497Q14185O95163Q14508P25942Q9Y6E0Q9UQF2   L22ab7P05gh4C10ef8P17cd1E22ef2I05cd4P19cd1F16cd5G02cd7G04ab6B01ab4P20gh6N01ab7B08ef6M02ab5E20ab3E15gh7K08ef2C24ab5K14cd6M19ab4P05cd3L05ef7M21ef7F15cd3J21cd5 肾结核1(少年)eIF4E转运蛋白HSPC182蛋白质环指蛋白1血红素结合蛋白质1多磷酸肌醇-4-磷酸酶；II型；105kD有丝分裂纺锤体装配物调节子1骨肉瘤中扩增的保守基因磷脂酰乙醇胺N-甲基转移酶H1组蛋白家族；成员2蜡样脂褐质沉积症；神经元5免疫球蛋白λ样多肽1骨髓/淋巴或混合性白血病(三空腔同系物；果蝇)白细胞介素增强子结合因子1营养不良聚糖1(营养不良蛋白相关糖蛋白1)蜡样脂褐质沉积症；神经元3；少年(Batten病；斯皮尔梅伊尔·沃格特病)脂肪酸去饱和酶3forkhead盒P1B细胞CLL/淋巴瘤6(锌指蛋白51)microspherule蛋白质1胞质分裂奉献者1B细胞中κ轻多肽基因增强子抑制子；激酶复合物相关蛋白质WAP四对二硫键核心结构域2肿瘤坏死因子受体超家族；成员5丝氨酸/苏氨酸激酶24(STE20同系物；酵母)促分裂原活化蛋白激酶8互作蛋白质1   115.0436106.343171.17119.2377181.0768183.6815143.9463134.0126138.4849427.1258148.999178.91644157.0713136.4076105.7987240.521117.082599.17408115.9704145.792795.3322203.0161102.6084110.0933206.7079229.9384   11017817512719613111791.312255875.414481.91309930211511485.9163112120201239225182   148.3613148.4323148.5234148.657148.7681148.785148.8487148.9901149.0109149.1016149.1361149.2005149.358149.4265149.6192149.6542149.704149.7517149.853149.9313150.0398150.0489150.0782150.083150.279150.2902   124.437144.3142165.0639131.6381175.2357154.5722136.7074124.7728136.3565377.9287124.5021123.9169129.4559138.6386118.1383230.6187127.2281120.8481117.2275153.0143118.9819157.6357151.3745166.2403194.1145187.4786   3.67E-014.81E-01-2.05E-013.18E-01-2.84E-01-3.04E-014.83E-021.53E-011.06E-01-1.52E+001.33E-039.19E-01-7.26E-021.32E-015.00E-01-6.85E-013.55E-015.95E-013.70E-014.04E-026.54E-01-4.36E-015.49E-014.47E-01-4.60E-01-6.13E-01   -6.59E-027.45E-013.60E-029.12E-021.13E-01-4.85E-01-2.95E-01-5.53E-01-1.88E-013.84E-01-9.83E-018.64E-01-9.39E-01-6.85E-02-9.59E-023.27E-01-2.72E-021.96E-01-4.34E-011.64E-012.27E-01-7.60E-019.73E-011.12E+001.25E-01-3.36E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y285Q04762Q9Y6J9O43913P25208Q9H9X4O95297Q9UPG8P16333Q14108Q9UFF9O15242Q13442Q99755Q9NZV1Q05195O95671Q9Y658Q9BTU6Q9UPN6O00170Q9UJW6Q9HCT0Q15459O95400P07954Q9H6Z5Q9HCN8Q92890O43324   D11ab5F09ab4P19ef6C06ab8M05cd1F03gh5P17cd4O06ab8H16ef5I22ab5O05cd5O19ab8N15ef3A15ef6E09gh2C09ab7J14ab2A09ef2N12gh6G04ef8J03ab2P01ef3N02ef8O03cd6G16cd6M06ab3C16gh5A05gh1A24cd4N24cd4   苯丙氨酸-tRNA合成酶样细胞基质粘附调节子TAF6样RNA聚合酶II；p300/CBP相关因子(PCAF)相关因子；65kD(复制)起点识别复合物；亚基5样(酵母)核转录因子Y；β假定蛋白质FLJ11618髓磷脂蛋白零样1多形腺瘤基因样2NCK衔接蛋白1CD36抗原(胶原I型受体；血小板反应蛋白受体)-样2(溶酶体膜内在蛋白质II)CCR4-NOT转录复合物；亚基8nardilysin(N-精氨酸二碱转化酶)PDGFA相关蛋白质1磷脂酰肌醇-4-磷酸5-激酶；I型；α富含半胱氨酸的运动神经元1MAX二聚蛋白质乙酰血清素O-甲基转移酶样RNA解旋酶磷脂酰肌醇4-激酶II型KIAA1116蛋白质芳烃受体互作蛋白质活性调节的细胞骨架相关蛋白质成纤维细胞生长因子22剪接因子3a；亚基1；120kDCD2抗原(胞质尾区)结合蛋白质2延胡索酸水合酶假定蛋白质FLJ21634间质细胞源性因子2样1泛素融合降解1样真核翻译延伸因子1ε1   179.7613134.159477.59128147.9187106.4862189.58127.461134.8747237.1463155.206162.9025210.0164156.1376112.2177112.5932136.899699.67178112.971597.30862127.681555.1127221.8559157.7471163.4432192.2313121.2546101.1467136.5604157.2559150.6748   14517615816813817912116535113920819818814699.125498.595.3178113223185126145238142152128220112   150.3716150.3997150.4181150.4866150.5231150.5879150.7509150.9533150.9549150.9785151.0687151.1245151.1314151.3432151.3541151.5662151.7064151.8988151.965152.0268152.0508152.1474152.2042152.3945152.5257152.5652152.6745152.9097152.9538152.9613   158.2291153.4581128.6968155.6272131.7807173.1977133.0095150.4388246.4108148.3416174.1041186.2788165.0545136.4804121.0073180.6838116.6189120.0494142.5367130.9048310.1793186.4423145.1536153.5048194.1745138.7259135.2933139.1775176.6159138.6164   -2.58E-011.65E-019.55E-012.48E-024.99E-01-3.32E-012.42E-011.62E-01-6.52E-01-3.98E-02-1.09E-01-4.75E-01-4.70E-024.32E-014.27E-011.47E-016.06E-014.27E-016.43E-012.52E-01-1.87E+00-5.44E-01-5.16E-02-1.01E-01-3.34E-013.31E-015.94E-011.63E-01-4.00E-022.17E-02   -3.14E-013.90E-011.03E+001.88E-013.77E-01-7.94E-02-7.72E-022.95E-015.66E-01-1.61E-013.55E-01-8.72E-022.67E-013.78E-01-1.85E-018.89E-01-1.74E-02-2.46E-018.74E-01-1.76E-01-1.31E+00-2.60E-01-3.30E-01-1.76E-013.07E-012.31E-015.88E-01-9.27E-024.82E-01-4.25E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NVU8Q9NQW6Q9NWH4Q9UBV8P15328Q9Y583Q07326O75396Q9Y2Z8Q9H3P7O95678P17026Q9Y3N9Q9BYT8Q9UHQ7O60921O00400Q9Y690Q9NZL9O60563P20591Q9BQC6P28838Q9NZE5Q9NX47O60612O00559Q9NUU9P22059O00408   H10gh2H01ef4L01gh2M13cd8F10ab3B01cd6M08ab8M12cd5D09ef2N05gh5E03cd5M04cd4M05gh7K08gh7F02ef8A22ab7D05ab2H01gh6L24ef7A05ab4M03ab7P14gh5J02ef1P08ef1K10gh2K11cd2F22cd4E17gh3C10ab8I05ef6  假定蛋白质FLJ10496anillin；肌动蛋白结合蛋白质(scraps同系物；果蝇)线粒体核糖体蛋白质L20具有长N端疏水结构域的PEF蛋白质(peflin)叶酸受体1(成体)NS1相关蛋白质1磷脂酰肌醇聚糖；F类SEC22小泡运输蛋白质样1(酿酒酵母)CGI-09蛋白质高尔基磷蛋白1细胞角蛋白II型锌指蛋白22(KOX 15)嗅觉感受器；家族2；亚家族W；成员1溶神经素(金属肽酶M3家族)pp21同系物HUS1检查点同系物(裂变酵母)乙酰辅酶A转运蛋白致命因子4甲硫氨酸腺苷基转移酶II；β细胞周期蛋白T1粘病毒(流感病毒)抗性1；干扰素可诱导蛋白质p78(小鼠)线粒体核糖体蛋白质63亮氨酸氨肽酶3假定蛋白质LOC51319假定蛋白质FLJ20445超绒毛蛋白雌激素受体结合位点相关；抗原；9假定蛋白质F23149_1oxysterol结合蛋白质磷酸二酯酶2A；cGMP刺激的   145.4398113.8655173.4347148.0371152.5051143.6283132.6521143.9018117.2943251.3681339.3692152.726127.252785.99781119.2248148.5718196.9505253.2426128.4144179.5706459.0611188.6422409.1007135.1502299.3918113.628181.5726140.3785133.2924860.2983   11985.61071441231779315311025819588.313719313620412425999.717187374.338317133827014722493.6169   152.9651152.992153.0783153.0828153.1163153.2797153.3084153.3626153.5282153.65153.797153.8779153.9228154.0005154.0057154.126154.2012154.2307154.2681154.2911154.338154.357154.3828154.3904154.4327154.4497154.679154.7106154.8714154.9688   139.1241117.4953144.3461148.3188142.7655157.8847126.3257150.1024126.8764220.9899229.3684131.6407139.4653144.2719136.5651169.0172158.3654222.1522127.4733168.3854495.4752139.1028315.6553153.3881263.9291179.421160.9495172.9723127.2507394.9107   7.28E-024.26E-01-1.80E-014.84E-025.77E-039.38E-022.09E-019.19E-023.88E-01-7.10E-01-1.14E+001.08E-022.75E-018.41E-013.69E-015.29E-02-3.53E-01-7.15E-012.65E-01-2.19E-01-1.57E+00-2.89E-01-1.41E+001.92E-01-9.55E-014.43E-01-2.31E-011.40E-012.16E-01-2.47E+00   -2.90E-01-4.11E-01-7.03E-01-4.15E-02-3.14E-012.99E-01-5.12E-018.88E-02-9.52E-023.73E-02-8.00E-01-7.90E-011.09E-011.16E+001.95E-014.60E-01-6.68E-013.23E-02-3.65E-01-6.81E-029.27E-01-1.34E+00-9.33E-023.36E-011.75E-011.25E+00-3.09E-016.73E-01-5.10E-01-2.34E+00   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O94935P41134P24407O00232Q01432Q13525Q16611Q9NPA3Q9GZM8P42702Q05940Q9Y3Q5Q15756O75386P50750Q9NWY6P50391Q9NX07O75354Q9H832Q9UBW8P14136Q9NYF3Q15056O15534   P22ef7H15ef5M08ab7N05ab8G04ab2G15cd4N04ab3C11gh5D14gh7P06ab6P07ef5H18cd6H08ab7M17cd3D03ef5A18gh3K05cd1L20gh6A15ab4L12gh5F18ef1E23ab5F08ef1A09gh2I16ab8   肌动蛋白突变的SAC1抑制子1样(酵母)DNA结合抑制剂1；显性负相螺旋-环-螺旋蛋白mel转化癌基因(来源自细胞系NK14)-RAB8同系物蛋白酶体(前体；macropain)26S亚基；非ATP酶；12腺苷一磷酸脱氨酶(同工型E)白细胞介素1受体样2BCL2-拮抗物/杀手1假定蛋白质STRAIT11499LIS1互作蛋白质NUDEL；内寡肽酶A白血病抑制因子受体溶质载体家族18(小泡单胺)；成员2推断DNA/染色质结合基序钾内部整流通道；亚家族J；抑制剂1桶状样蛋白质3周期素依赖性蛋白激酶9(CDC2相关激酶)假定蛋白质FLJ20531胰多肽受体1tRNA硒代半胱氨酸相关蛋白质外核苷三磷酸二磷酸水解酶6(推断功能)假定蛋白质FLJ13855COP9组成型光形态形成同系物亚基7A(拟南芥)胶质细胞原纤维酸性蛋白染色体5开放阅读框6Williams-Beuren综合征染色体区1period同系物1(果蝇)   146.0417434.1844224.1153122.517111.1766136.0802280.4131112.5378137.823592.44914374.490175.96908149.0689128.6914270.822991.85185136.5278258.434386.4989173.4437102.8052108.166121.4116202.4969237.2007   12829218913911713019485.513111215315080.982.721513011228725830711186.694.3124143   154.9914155.0439155.1684155.2465155.341155.4674155.5414155.5531155.5611155.6189155.637155.6726155.7504155.7811155.8317156.1332156.1953156.2449156.4638156.9292157.0119157.2761157.5806157.6763157.7195   142.9113293.8674189.5598139.0276127.7664140.5051210.0516117.8671141.4354120.0363227.6447127.0621128.583122.3782213.7777125.9903134.9143233.9363267.133212.3427123.4686117.3353124.4392161.3602179.3665   8.58E-02-1.49E+00-5.30E-013.42E-014.83E-011.92E-01-8.50E-014.67E-011.75E-017.51E-01-1.27E+001.04E+006.33E-022.76E-01-7.97E-017.65E-011.94E-01-7.26E-01-1.30E+00-1.44E-016.11E-015.40E-013.76E-01-3.61E-01-5.89E-01   -1.94E-01-5.70E-01-2.43E-011.85E-017.10E-02-6.63E-02-5.30E-01-3.96E-01-7.41E-022.77E-01-1.29E+009.77E-01-8.81E-01-6.39E-01-3.35E-015.01E-01-2.85E-011.52E-01-5.81E-018.22E-011.05E-01-3.21E-01-3.64E-01-7.09E-01-7.28E-01   1111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y399O14972Q14113O95755Q9NPC3Q9Y6E9Q9Y5B8P49642O60660Q9H251Q9Y6C2O95825Q9UHG3O00629Q15397Q14999Q12772O75150O43423O43311Q9NYX4Q9HD71Q9NZH2Q9NVH1Q9NVG3P52179O94815Q9UBY9Q9NVX7O95704   O21ef2A04cd6M15ab2O18cd5I09gh4N24cd7D17cd8I21ab8J04ab2O08gh7A22cd7D13cd5J02ef2J18ab6B14gh1H01gh1M18cd2F09gh1L07gh6D12cd8B07ef4G04gh4N03cd8B05gh3B11gh3A21cd4B09cd3G01ef4G18gh3A02cd6   线粒体核糖体蛋白质S2唐氏综合征临界区域基因3AE结合蛋白质1RAB36；成员RAS癌基因家族入侵增强子10sirtuin沉默交配型信息调节2同系物2(酿酒酵母)NME7引发酶；多肽1(49kD)ash2(无；小；或同源异型)样(酵母)钙粘蛋白相关23位于弹性蛋白微原纤维界面的蛋白质晶体蛋白；ζ(醌还原酶)样1异戊二烯半胱氨酸裂合酶karyopherinα4(importinα3)KIAA0020基因产物KIAA0076基因产物甾醇调节因子结合的转录因子2环指蛋白40酸性(富含亮氨酸)核磷蛋白32家族；成员Cmuscleblind样(果蝇)calcyon；D1多巴胺受体互作蛋白质假定核因子SBBI22复制起始区蛋白质(60kD)假定蛋白质FLJ10737假定蛋白质FLJ10751myomesin 1(骨架蛋白)(185kD)卷曲周系物1(果蝇)热休克27kD蛋白质家族；成员7(心血管)假定蛋白质FLJ10450FE65样蛋白质2   229.9134230.0837124.9796132.9919104.2128111.855792.69165135.2376274.3502113.1038107.9751144.0183250.3969518.8184109.853371.35119158.6108129.2351140.3006165.2243207.2791123.7874225.0949137.467396.28296157.060893.9787798.97552111.519699.35088   13926795.39712115311670.217718492.213320729513417394.616914399.414714017921710594101102121115   157.7339157.7386157.955158.0474158.1023158.2227158.2444158.2887158.3372158.4524158.6648158.6719158.8419158.8458158.9595159.0037159.1986159.2038159.4372159.4681159.5302159.5491159.6113159.6304159.6829159.8272159.9198160.1725160.2507160.3239   175.5893218.3678126.0667129.3518127.8011140.9006122.4719121.2327203.1619151.9031119.6097145.1487205.2993324.141134.3527134.6153137.4667152.3442147.5392141.3508171.42141.2517187.9443171.2625120.1783136.9676118.2939120.3216130.905124.7475   -5.44E-01-5.45E-013.38E-012.49E-016.01E-015.00E-017.72E-012.27E-01-7.93E-014.86E-015.55E-011.40E-01-6.57E-01-1.71E+005.33E-011.16E+005.34E-033.01E-011.84E-01-5.12E-02-3.78E-013.66E-01-4.96E-012.16E-017.30E-012.52E-027.67E-016.94E-015.23E-016.90E-01   -7.25E-012.16E-01-3.92E-01-4.55E-012.17E-014.48E-013.30E-01-9.47E-01-6.34E-017.03E-01-2.28E-01-1.17E-01-2.77E-01-8.16E-012.89E-011.28E+00-7.46E-013.84E-012.63E-02-7.34E-01-4.91E-011.82E-01-3.30E-016.57E-011.19E-01-7.40E-011.04E-014.08E-021.17E-012.06E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P19801O43709Q12839O43503Q07898O96015Q92524Q92692Q9Y6Y8Q9NZ78Q15120P35241Q9Y326Q92600O00487Q9Y689Q9ULB8O60897P51809O75581O43795Q14188P06280Q14541P57723Q9NWU3   A23ab2L18ef3N24ef1D10ab8J10cd4F22cd5L11ab8B06ab8I16cd7J16gh3G15cd1F22ab8D23ef2J03cd5N14cd5P21cd7P05cd8L09cd7J05cd2A03ab7F12ef4H17ef5B07ab3O17ab7E17gh8A24gh3   amiloride结合蛋白质1(胺氧化酶(含铜))Williams-Beuren综合征染色体区20H326RAD51同系物C(酿酒酵母)CD163抗原动力蛋白；基因丝的；轻链多肽4蛋白酶体(前体；macropain)26S亚基；ATP酶；6脊髓灰质炎病毒受体相关2(疱疹病毒进入介质B)Sec23互作蛋白质p125非特征性骨髓蛋白质BM045丙酮酸脱氢酶激酶；同工酶3根蛋白脑特异性蛋白质RCD1细胞分化所需1同系物(裂变酵母)26S蛋白酶体相关pad1同系物ADP核糖基化因子样5CMP-NeuAC：(β)-N-乙酰半乳糖胺(α)2；6-唾液酸转移酶成员VIRAB；RAS癌基因家族成员样4小突触泡蛋白样1低密度脂蛋白受体相关蛋白质6肌球蛋白I类；myh-1c转录因子Dp-2(E2F二聚体配偶体2)半乳糖苷酶；α肝细胞核因子4；γ多聚(rC)结合蛋白质4DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽27   164.6296127.8538109.67796.3477987.7356394.54055396.6515302.7185104.2429107.200196.64061276.6012359.3582115.6633329.3518137.773791.0112889.32474228.3546122.4708259.4543107.308178.0238549.8997186.2845154.71   68.313411697.6177251220317131127107213160145275159121112141125282204304283231104   160.3477160.4415160.6141160.6551160.8614160.9963161.0391161.2569161.2684161.3587161.6468161.7003161.7123161.7142161.8834161.8965161.9148162.0127162.1052162.1159162.137162.1489162.2871162.4659162.5267162.6529   131.0836140.7865128.8096118.1934141.7231168.8465259.1219260.2905132.2965131.7449121.6758216.9693227.0406140.923255.4035152.9706124.5785120.9939177.2043136.4067234.504157.7494214.6169331.895193.1283140.5056   -3.80E-023.28E-015.50E-017.38E-018.75E-017.68E-01-1.30E+00-9.09E-016.30E-015.90E-017.42E-01-7.74E-01-1.15E+004.84E-01-1.02E+002.33E-018.31E-018.59E-01-4.94E-014.05E-01-6.78E-015.96E-01-1.34E-01-1.76E+00-1.97E-017.22E-02   -1.27E+006.84E-028.26E-021.83E-021.01E+001.41E+00-8.52E-016.60E-023.34E-012.41E-011.43E-01-3.80E-01-1.17E+003.30E-01-2.60E-012.09E-014.09E-013.22E-01-6.94E-012.53E-021.20E-019.25E-017.70E-01-9.57E-013.08E-01-5.71E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NPC5Q9Y3C5Q9NWX3P52742Q9Y313Q9P2W9P14778Q15464O15444P49796Q9NUS7P48651Q07706O75143O75039P02261Q9H9A0Q9NV35Q9P1G8P26368Q9BSZ7Q9Y391Q9NYR5P05165Q9NPF4P16106P35249P28702P49674   J16ef8B19ef3B01gh2I22cd3D17ef2B11ef4F09ab6I12ef5H07cd2P14ef4B04gh3L11ef3F15cd4B11gh1L19gh1M10gh6L20gh5J21gh3C05gh4D11cd7E11gh8G23ef2E05ef3N12ab7O21gh3D01cd3O03ef5P18gh1K14ab4   nudix(二磷酸核苷连接部分X)型基序4环指蛋白11染色体20开放阅读框27锌指蛋白135(克隆pHZ-17)PTD013蛋白质突触融合蛋白18白细胞介素1受体；I型SHB(包含Src同系物2结构域)衔接蛋白B可诱导小细胞因子亚家族A(Cys-Cys)；成员25G蛋白信号调节子3假定蛋白质FLJ11164磷脂酰丝氨酸合酶1四环素转运蛋白样蛋白质KIAA0652基因产物KIAA0451基因产物H2A组蛋白家族；成员N假定蛋白质FLJ12895假定蛋白质FLJ10956包含WW结构域的带有卷曲螺旋区的衔接蛋白U2核内小分子核糖核蛋白辅助因子(65kD)DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽37雄激素调节的短链脱氢酶/还原酶1HSPC126蛋白质丙酰辅酶A羧化酶；α多肽O-唾液酸糖蛋白内肽酶H3组蛋白家族；成员K复制因子C(激活子1)4(37kD)视黄醇类X受体；β酪蛋白激酶1；ε   107.1863160.063198.5848281.414190.25232128.6426264.5401284.291244.6426220.276981.76063211.8695143.0791106.5331174.14293.4859186.4259999.15342119.4436217.0564130.7858222.349799.37243100.892103.822399.19006105.240674.91499.33956   98.416495.612111618853930197.199.311413914415513527313015418210711112811012011213098.7142145   162.6929162.7518162.7744162.8382163.4053163.4277163.4432163.5379163.6053163.6222163.6422163.6792163.7206163.7687163.8572163.8621164.3655164.4852164.5311164.8861164.9084164.9823165.2098165.6902165.9716166.1216166.2092166.2214166.3564   122.7442162.3366118.9844121.6363123.3545160.0555322.4754249.6096168.4558161.0774119.7258171.5708150.2019141.6405157.7714176.9259126.7707139.1489155.3256163.126135.6059171.7067124.8579128.9755127.3658131.6683123.3812127.7227136.8564   6.02E-012.40E-027.23E-011.00E+008.56E-013.45E-01-6.95E-01-7.98E-01-5.80E-01-4.29E-011.00E+00-3.72E-011.94E-016.20E-01-8.78E-028.10E-019.27E-017.30E-014.62E-01-3.97E-013.34E-01-4.31E-017.33E-017.16E-016.77E-017.44E-016.59E-011.15E+007.44E-01   -1.24E-013.68E-02-4.44E-025.68E-013.67E-015.48E-011.03E+008.24E-02-1.33E+00-1.15E+004.77E-01-6.06E-017.31E-035.37E-01-3.64E-011.55E+005.84E-016.33E-016.08E-01-1.01E+00-2.35E-01-7.99E-011.46E-012.54E-011.13E-013.87E-01-9.27E-029.23E-015.44E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NXW2O14672Q9Y5B9Q9H9J2P23759Q16643P48454Q9Y508P19474P46109P54855Q14242Q9BSS1Q9Y3B2P31391O60623Q99959Q01658Q9HCS4Q9P035Q9C0K7Q9NYF4P30042   I03gh2I01ab2I20cd7H22gh5G06ab8L05ab4I21cd1F21ef4G09cd2N13ab5B19cd4H14cd1P17gh8L23ef1N03cd1O03ab4L24ab8B21gh7P18ab5P10gh7N20ef2P24gh3I13ef3M19cd4  DnaJ(Hsp40)同系物；亚家族B；成员12解聚素及金属蛋白酶结构域10染色质特异性转录延伸因子大亚基线粒体核糖体蛋白质L44配对盒基因7肌联脑蛋白1蛋白质磷酸酶3(从前2B)；催化亚基；γ同工型(钙调神经磷酸酶Aγ)锌指蛋白313舍格伦综合征抗原A1(52kD；核糖核蛋白自身抗原SS-A/Ro)v-crk肉瘤病毒CT10癌基因同系物(鸟类)样UDP糖基转移酶2家族；多肽B15选择蛋白P配基假定蛋白质FLJ14525酵母体外核心蛋白质同系物CSL4生长抑素受体4白喉酰胺生物合成所需白喉毒素抗性蛋白质样2(酿酒酵母)plakophilin 2白细胞免疫球蛋白样受体；亚家族A(无TM结构域)；成员5转录下调子1；TBP结合(负性辅因子2)HMG盒转录因子TCF-3丁酸诱导转录物1肌萎缩侧索硬化2(少年)染色体区；候选物2染色体5开放阅读框7染色体21开放阅读框33   247.7907378.0042163.0543206.42892.41833265.008105.9496331.595301.1776151.2065137.8939112.967986.75908152.0751147.3942210.9658362.9423139.2571205.224976.48423102.716102.35289.7290898.84241   23522618825620015216939518314112713011314092.517021123412215614210813797.5   166.4412166.5417166.6045166.8142166.8514166.9734167.0428167.2366167.414167.7716167.8346167.9184167.974167.9915168.0254168.0762168.1655168.1829168.2606168.2926168.3034168.4355168.4424168.5171   216.5041256.8185172.4726209.7386153.0178194.7352147.2674297.9139217.1349153.202144.2152136.8261122.482153.2264135.9754183.0009247.4823180.4876165.0596133.5936137.5999126.1345131.7509121.6076   -5.74E-01-1.18E+003.11E-02-3.07E-018.52E-01-6.66E-016.57E-01-9.88E-01-8.47E-011.50E-012.83E-015.72E-019.53E-011.44E-011.89E-01-3.28E-01-1.11E+002.72E-01-2.87E-011.14E+007.12E-017.19E-019.09E-017.70E-01   -7.47E-02-7.43E-012.04E-013.10E-011.11E+00-8.00E-016.72E-012.52E-01-7.20E-01-1.05E-01-1.20E-011.98E-013.78E-01-1.23E-01-6.72E-01-3.12E-01-7.80E-017.49E-01-7.54E-011.03E+004.65E-017.24E-026.11E-01-2.03E-02   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O75325Q9Y670Q9UPR8Q9Y2X7P47872O43353P32321O43612Q92874Q9UI90P30519Q9NVE7Q9P010Q9UH59Q9UM82Q9P2Y4Q9GZS3P07686Q9NZV6O14678P29972O95373Q15436Q9BQ67P35321Q9UPQ8O43292Q9UBM3P19338   K16cd6N01ef2I14ef8I21ef4D24cd1C17cd4P14ab5J16ab4M15ab4I15ef8N05ab6D03gh3A14ef8M04cd8E01cd6N14ef1H19gh7J17ab3L06ef2E17cd1O04ab2D03cd6O12cd6K23gh8D21gh6I10ef8A19cd4G02cd1M20ab7   神经胶质瘤于染色体1扩增的蛋白质(富含亮氨酸)瞬时型感受器电位阳离子通道；亚家族V；成员2KIAA1084蛋白质G蛋白偶联受体激酶互作子1胰泌素受体受体互作丝氨酸-苏氨酸激酶2dCMP脱氨酶下丘泌素(食欲素)神经肽前体脱氧核糖核酸酶I样2PRO0038蛋白质血红素加氧酶(去循环)2假定蛋白质FLJ10782HSPC154蛋白质包含bromodomain的7精子发生相关2锌指蛋白219重组蛋白质REC14氨基己糖苷酶B(β多肽)含硒蛋白质X；1ATP结合盒；亚家族D(ALD)；成员4水通道1(通道形成膜内在蛋白质；28kD)RAN结合蛋白质7Sec23同系物A(酿酒酵母)富含谷氨酸的WD重复蛋白质GRWD富含脯氨酸的小蛋白质1AKIAA1094蛋白质GPAA1P锚附着蛋白1同系物(酵母)蛋白酶体(前体；macropain)26S亚基；ATP酶；4核仁蛋白   116.323996.41826101.3235160.7403174.6672272.5279218.568566.45691218.178789.17218586.3897141.6695227.9143147.6635230.7114105.6753124.7245217.0423241.363377.65216309.1218247.436890.05071140.319862.2827176.7624595.36294287.6026148.8642   83.390.811116720938860.119414638938714824610322117516213520212713411310011223712392.420487.6   168.5172168.5297168.5336168.7352168.738168.7722168.8404168.9064168.9596168.9849169.1269169.2644169.4393169.5045169.6678169.7666169.9984170.0092170.0232170.0525170.2078170.45170.9386170.966171.0104171.0467171.0704171.1554171.2094   122.705118.5764126.797165.5706184.1802276.5664149.1554143.2577177.8201215.61380.9032152.9293214.317139.9456207.1298150.1216152.3724174.0094204.3052124.9148204.2885177.0459120.3545141.0924156.8515123.4833119.6038221.0285135.8947   5.35E-018.06E-017.34E-017.00E-02-4.98E-02-6.91E-01-3.72E-011.35E+00-3.69E-019.22E-01-1.79E+002.57E-01-4.28E-011.99E-01-4.43E-016.84E-014.47E-01-3.52E-01-5.05E-011.13E+00-8.61E-01-5.38E-019.25E-012.85E-011.46E+001.16E+008.43E-01-7.49E-012.02E-01   -4.82E-01-8.69E-021.26E-015.72E-022.60E-015.11E-01-1.86E+001.55E+00-5.76E-012.12E+00-5.99E-016.16E-021.08E-01-5.24E-01-6.20E-027.27E-013.81E-01-6.85E-01-2.60E-017.10E-01-1.21E+00-1.13E+001.52E-01-3.25E-011.93E+006.76E-01-4.59E-02-4.93E-01-7.65E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NPE6O00442P28356P49447Q9UQA4O15254Q9NWW6O75391Q92959O00499Q14197Q9NXS9O75954Q9UJY9P82912Q12918Q14789Q04206P19838Q92748O95095P52209P42566Q13772P43897P09329   E17gh1J12cd3D09ef1G06ef1P18cd4D09ab2B11gh2M08cd5H19cd2G06ab2J05ab6K15gh2N18cd6E17cd8F10gh5J02ab6E01ab6I23ef6M15ef5A24cd2P13ab2K18ab8H10ef5D05gh6D09gh6D08ef7   精液相关抗原4包含RTC结构域的1同源异形盒D9细胞色素b-561核因子(红系源性2)样3乙酰化辅酶A氧化酶3；降植烷酰假定蛋白质FLJ20559精液相关抗原7溶质载体家族21(前列腺素转运蛋白)；成员2桥接整合物1未成熟的结肠癌转录物1假定蛋白质FLJ20071四跨膜4超家族侍卫线粒体核糖体蛋白质S11杀伤细胞凝集素样受体亚家族B；成员1高尔基自身抗原；高尔基亚家族b；macrogolgin(带有跨膜信号)；1v-rel网状内皮组织增殖病毒癌基因同系物A；B细胞中κ核因子轻链多肽基因增强子3；p65(鸟类)B细胞中的核因子κ轻链多肽基因增强子1(p105)甲状腺激素反应性(SPOT14同系物；大鼠)淀粉状蛋白β前体蛋白质(胞质尾区)结合蛋白质2磷酸葡萄糖酸脱氢酶表皮生长因子受体通路底物15核受体共活化物4Ts翻译延伸因子；线粒体磷酸核糖焦磷酸合成酶1   111.172274.670184.5638174.7152227.4253192.2301198.7861154.115986.25485162.858490.92583121.457583.06795156.5909105.0578205.622596.09162328.9295229.2262101.3906199.951211.8178194.9437273.5167325.7575103.7882   13527910616747019222014010211110210311975.619629019424227788.220114715836722686.2   171.4356171.531171.5949171.6447171.8945172.0218172.0261172.0658172.112172.4453172.5526172.5552172.5557172.6495172.7091172.8141173.0059173.0443173.0997173.314173.3314173.42173.4643173.5038173.8489174.5738   139.3341241.6967120.5873171.1671289.7702185.2853197.0098155.2376120.1434148.8447121.725132.3749124.8565134.9529158.0886222.8453154.2154248.1566226.323120.9562191.35177.5327175.3861271.4641241.8156121.5057   6.25E-01-6.79E-011.02E+00-2.56E-02-4.04E-01-1.60E-01-2.09E-011.59E-019.97E-018.25E-029.24E-015.07E-011.05E+001.41E-017.17E-01-2.51E-018.48E-01-9.27E-01-4.05E-017.73E-01-2.06E-01-2.89E-01-1.68E-01-6.57E-01-9.06E-017.50E-01   2.84E-012.20E-023.21E-01-6.39E-021.05E+00-4.71E-031.48E-01-1.43E-012.43E-01-5.50E-011.62E-01-2.36E-015.18E-01-1.05E+009.03E-014.97E-011.01E+00-4.40E-012.71E-01-2.02E-015.88E-03-5.23E-01-3.05E-014.26E-01-5.28E-01-2.69E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O75618Q9UHI9Q9H824Q9UQ43O43173Q9BZZ2Q92611Q969V6P08107Q9BQ24Q9H7X1Q99616Q92896Q14582Q13505Q13722P01308O00405P41215P31314O95427Q12981Q9Y5V1Q9H4B4Q9H6D1O60504Q9UNK0O95657   F24cd4B18ef1J07gh6G07ab3N08ef1G13gh7I16gh1K14gh7K14ab7E21gh6N07gh5D09cd2L04cd7J16ef6K21ab7O24cd8I10ab6D19ab8E03ab5F04ef6G21cd8C24ef6L10ef1O22ab4P15gh5J18cd5I02cd5B24cd4   包含死亡效应子结构域flavohemoprotein b5+b5R仅有F-盒的蛋白质22BAI1相关蛋白质2唾液酸转移酶8C(α2；3Galβ1；4GlcNAcα2；8-唾液酸转移酶)唾液酸粘附素KIAA0212基因产物巨核母细胞白血病(易位)1热休克70kD蛋白质1B假定蛋白质MGC2550假定蛋白质FLJ14153可诱导小细胞因子亚家族A(Cys-Cys)；成员13高尔基体蛋白质1Mad4同系物metaxin 1染色体3p21.1基因序列胰岛素蛋白磷酸酶1；调节亚基10脂肪酸辅酶A连接酶；长链1同源异形盒11(T细胞淋巴瘤3相关断点)磷脂酰肌醇聚糖；N类BCL2/腺病毒E1B 19kD互作蛋白质1HSPC042蛋白质细胞因子可诱导性激酶染色体20开放阅读框81vinexinβ(包含SH3的衔接分子-1)突触融合蛋白8脯氨酸-丝氨酸-苏氨酸磷酸酶互作蛋白质1   172.0163169.202889.2751184.8198220.9909147.5296.3144135.6533153.5141153.9741155.291130.164197.73429210.3185199.123185.85963367.022233.0866267.9822107.412784.2281782.38214212.074161.98295.43432109.3831218.2149369.9485   17619716116525618994.316110625523610090.324416814411330619917011699.818419410899.8171158   174.7689174.7919175.62175.6399175.9869175.9952176.0348176.0531176.1145176.3889176.5938176.5958176.622176.6383176.6745176.7101176.7437176.8763177.1301177.4236177.4629177.5246177.7635177.788177.8526177.8876177.9777178.0072   174.3849180.2862141.9533175.1475217.6266170.7942122.2106157.6423145.1219195.2182189.2619135.6192121.5361210.1876181.2437135.6336218.8465238.6383214.8046151.5175125.8189119.9152191.3703177.8629126.9312129.0088189.0342235.2956   2.29E-024.69E-029.76E-01-7.35E-02-3.29E-012.55E-018.70E-013.76E-011.98E-011.96E-011.85E-014.40E-018.54E-01-2.52E-01-1.73E-011.04E+00-1.05E+00-3.98E-01-5.97E-017.24E-011.08E+001.11E+00-2.55E-011.34E-018.98E-017.02E-01-2.94E-01-1.06E+00   3.61E-022.18E-018.50E-01-1.64E-012.12E-013.56E-01-3.08E-022.49E-01-5.38E-017.29E-016.03E-01-3.79E-01-1.15E-012.12E-01-2.46E-017.49E-01-1.70E+003.92E-01-4.27E-016.60E-014.59E-012.77E-01-2.03E-012.59E-011.72E-01-1.33E-01-3.53E-01-1.23E+00   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P20645O14569O15293P00390Q9HBV3Q14558O14710Q9UJ70Q13397Q9NRG4P51449Q9H768Q14332Q13207Q9H6B8O00462Q9Y3D8P17900Q9P0M4Q9NZ92Q9NX94P04049Q13181P22102Q9NQZ8Q9UN30   C05ab7B03ab2D18cd3E14ef7K24gh5H17ab8F01ef5J10ef3M18cd6B21gh4B01cd2O21gh7F22ef5N13cd2B19gh5J09ab7H14ef2F19ab3O10cd8F13gh8J02gh3L18gh6G12ef5B06cd1M05ab6A09gh5D04cd2   甘露糖-6-磷酸受体(阳离子依赖性)推断的肿瘤抑制基因MAP-激酶活化的死亡结构域谷胱甘肽还原酶PP3111蛋白质磷酸核糖焦磷酸合成酶相关蛋白质细胞周期进程2蛋白质N-乙酰葡糖胺激酶锌指蛋白238HSKM-B蛋白质RAR相关孤儿受体C突触结合蛋白样2卷曲同系物2(果蝇)T-盒2类似于小鼠Dnajl1的假定蛋白质甘露糖苷酶；βA；溶酶体肾上腺蛋白质AD-004GM2神经节苷脂激活蛋白白细胞介素17CG蛋白偶联受体54SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族f；成员1假定蛋白质FLJ20154v-raf-1小鼠白血病病毒癌基因同系物1ATP结合盒；亚家族E(OABP)；成员1磷酸核糖基甘氨酰胺甲酰基转移酶；磷酸核糖甘氨酰胺合成酶；氨基咪唑核苷酸合成酶肿瘤坏死因子α诱导的内皮细胞锌指蛋白中足性梳样1(果蝇)   355.8249122.4884157.092282.1492229.2714301.219261.2178151.2986215.883143.1326236.697783.7825586.25011118.9378134.33883.23817178.4931124.7747260.875387.92591267.7307133.6318225.086167.9383295.048996.7928497.47885   23479.211419636122718927628527997.212112910812910716323222313324716518312718013886   178.1318178.136178.1677178.1741178.4093178.4567178.7923178.7992178.9318178.999179.0372179.0813179.1323179.1858179.5015179.6953179.7989179.914180.0241180.0735180.206180.3424180.3925180.4651180.5026180.7283181.0121   256.0667126.62149.8523218.8246256.1517235.5213209.7103201.9381226.5893200.3335170.992128.0355131.3078135.2524147.5119123.2365173.7578178.9056221.2511133.5723231.4963159.7713196.2063158.5133218.4202138.4428121.4921   -9.98E-015.40E-011.82E-01-6.63E-01-3.62E-01-7.55E-01-5.47E-012.41E-01-2.71E-013.23E-01-4.03E-011.10E+001.05E+005.91E-014.18E-011.11E+001.05E-025.28E-01-5.35E-011.03E+00-5.71E-014.32E-01-3.19E-011.04E-01-7.09E-019.01E-018.93E-01   -6.03E-01-6.28E-01-4.59E-01-5.24E-016.54E-01-4.09E-01-4.66E-018.66E-014.00E-019.62E-01-1.28E+005.33E-015.76E-01-1.44E-01-6.19E-023.59E-01-1.31E-018.95E-01-2.27E-015.94E-01-1.19E-013.07E-01-2.98E-01-4.02E-01-7.15E-015.10E-01-1.81E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P26651P18887Q9Y2S0P49023P49321Q13428Q9HCS6P20813O00459P50151Q16850Q9ULW3Q16378P41240Q16649Q9Y3M2Q9UK58P47874O95620Q9UHV2P02810O94903Q9P0W6Q9H8X4P02786Q99717   J04ef6O06ef6P14ef1I05ef7O03ab7M14cd1G07gh4I02gh6C05cd1H24ab4D12ab3J09cd8O20cd7J14ab4G05cd1J03ef8M14gh4M23cd1O03cd7J11cd8F07gh6K04cd7I03ef4O15gh5D24ef5E15ef1J01ab7   锌指蛋白36；C3H型；同系物(小鼠)中国仓鼠细胞中X射线修复互补缺陷修复1RNA聚合酶I 16kDa亚基桩蛋白核自身抗原性精蛋白(组蛋白结合)特-弗二氏综合征1空泡蛋白质分选11(酵母)细胞色素P450；亚家族IIB(苯巴比妥可诱导性)；多肽6磷酸肌醇-3-激酶；调节亚基；多肽2(p85β)鸟嘌呤核苷酸结合蛋白10细胞色素P450；51(羊毛甾醇14-α-脱甲基酶)TATA结合蛋白质结合蛋白质富含脯氨酸4(眼泪)c-src酪氨酸激酶核因子；白细胞介素3调节的染色体22开放阅读框2细胞周期蛋白L ania-6a嗅觉标志蛋白质类似于大肠杆菌yhdg和光合菌nifR3的蛋白质CDK4结合蛋白质p34SEI1富含脯氨酸蛋白质HaeIII亚家族1脯氨酸合成酶共转录同系物(细菌)脂多糖特异性反应7蛋白质基质膜相关蛋白质转铁蛋白受体(p90；CD71)免疫球蛋白重链恒定区εMAD；母抗decapentaplegic同系物5(果蝇)   286.073385.61601182.9338313.7788119.903164.3621177.2833122.3562145.3741186.5329353.966797.2345481.91175.1285353.669874.27488191.3619250.3691227.8932144.2806410.3478242.2062149.1418358.1542320.8365386.489227.5817   16210214933478.2123302162160193116207152153169194313172207163392146177342257176153   181.0638181.0778181.2184181.2995181.3524181.4282181.4601181.476181.534182.0963182.1309182.1565182.3589182.4257182.4266182.6022182.6351182.73183.1055183.5211183.6977183.9744184.0725184.0879184.2545184.3533184.3978   209.8211122.9254170.8985276.3491126.4866156.2838220.0848155.3947162.3275187.0796217.3331162.0616138.8678170.0806235.1072150.2264229.0134201.6274205.8925163.6559328.6668190.7733169.9232294.6026254.0696249.0303188.4757   -6.60E-011.08E+00-1.36E-02-7.91E-015.97E-011.43E-013.36E-025.69E-013.20E-01-3.47E-02-9.59E-019.06E-011.15E+005.89E-02-9.55E-011.30E+00-6.73E-02-4.54E-01-3.16E-013.47E-01-1.16E+00-3.97E-013.04E-01-9.60E-01-8.00E-01-1.07E+00-3.04E-01   -8.17E-012.54E-01-3.00E-019.00E-02-6.17E-01-4.18E-017.66E-014.08E-011.39E-014.62E-02-1.61E+001.09E+008.95E-01-1.98E-01-1.06E+001.38E+007.10E-01-5.43E-01-1.41E-011.77E-01-6.62E-02-7.29E-012.43E-01-6.84E-02-3.19E-01-1.13E+00-5.69E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q15036P31751P11177Q9UEQ6Q16531P28698P41968P54920Q99487Q9H0C8P17252P06493O00139P54259Q99757Q9NW68P16106P40692Q99798P53618Q9UJ69Q9NRM2Q92879O75399Q9BZE4Q9NXB2   B23gh1A08ab2G21ab8F22ab2J11ab5G24cd3N12ef4E03cd4C19ab8N15gh7F17ab8B01ef5C14ab7N05ef6G10cd8B12gh2O16gh6M06ef6E01ab2A11ef3N24gh2P22ef8B06cd6H22gh1I17cd8G08gh2   分选连接蛋白17v-akt小鼠胸腺瘤病毒癌基因同系物2丙酮酸脱氢酶(硫辛酰胺)β(视紫红质)抑制蛋白；β2损伤特异性DNA结合蛋白质1(127kD)锌指蛋白42(骨髓特异性视黄酸反应性)黑皮质素3受体N-己基顺丁烯二酰亚胺敏感因子吸附蛋白质；α血小板活化因子乙酰水解酶2(40kD)整联蛋白连接的激酶相关丝氨酸/苏氨酸磷酸酶2C蛋白激酶C；α细胞分裂周期2；G1-S和G2-M驱动蛋白重链成员2齿状核红核苍白球丘脑下部核萎缩(atrophin-1)硫氧还蛋白2假定蛋白质FLJ10276H3组蛋白家族；成员JmutL同系物1；结肠癌；非息肉型2(大肠杆菌)顺乌头酸酶2；线粒体coatomer蛋白质复合物；亚基βToll互作蛋白质锌指蛋白277CUG三联重复；RNA结合蛋白质1变形表皮自动调节因子1(果蝇)G蛋白结合蛋白质CRFG假定蛋白质FLJ20343   303.8909253.7531229.1486190.7331205.193476.12612225.3987306.753228.4138120.8459108.3851108.1696140.4141165.5295309.0415107.4044137.991498.77988615.211238.4951211.4055232.9567217.3752189.8387151.2547259.0672   4112531501282291052872672411097476.2205152163242135108291102259227198266214285   184.4831184.8245185.0719185.1221185.1363185.3347185.5363185.697185.7091185.7532185.8466185.8754185.9437186.0962186.106186.1575186.2589186.2872186.5524186.6268186.6408186.8854187.122187.2872187.3094187.4246   299.6453230.4512188.1769167.9086206.5357122.3029232.6783252.9933218.5222138.517122.7553123.4207177.1988167.773219.4587178.6551152.9203131.0441364.1757175.716219.0188215.6334200.6744214.4669184.3092243.8822   -7.20E-01-4.57E-01-3.08E-01-4.31E-02-1.48E-011.28E+00-2.81E-01-7.24E-01-2.99E-016.20E-017.78E-017.81E-014.05E-011.69E-01-7.32E-017.93E-014.33E-019.15E-01-1.72E+00-3.54E-01-1.80E-01-3.18E-01-2.16E-01-1.95E-023.08E-01-4.67E-01   4.34E-01-5.57E-03-6.08E-01-5.77E-011.60E-014.70E-013.49E-01-2.03E-018.00E-02-1.49E-01-5.50E-01-5.05E-015.48E-01-1.26E-01-9.21E-011.17E+00-3.69E-021.30E-01-1.08E+00-1.23E+002.93E-01-3.70E-02-1.38E-014.88E-015.03E-011.38E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O95424P54577O43692O60507Q9BYS9P32780Q14004Q15910P47974Q13177P98172Q9BQB1O75472O75608O00193Q14452P55268Q9P006Q9Y3B5Q9NQ34Q9NWY4Q9UBS8Q9UBS4Q12797Q9H4I9O14907Q14673Q9NWB7Q9BVH4P22897   M06ef4D14cd3N03ef7J03cd3B15gh5G11ab6D07ef5L08ab5H22ab4E20ab8P16gh8J01ef7N04gh6H11cd5K06cd6E14ef3B08ab5P18ef6A20ef8P07ef1A10gh4O14gh2P17ab2J06ef2J22ab2P10gh8E24ef8B09gh1P01gh2G21gh6I17ab7  MYLE蛋白质酪氨酰-tRNA合成酶蛋白酶抑制剂15酪氨酰蛋白磺基转移酶1MMS19样(MET18同系物；酿酒酵母)普通转录因子IIH；多肽1(62kD亚基)细胞分裂周期2样5(胆碱酯酶相关细胞分裂控制子)zeste同系物增强子2(果蝇)锌指蛋白36；C3H型样2p21(CDKN1A)活化的激酶2包含杆状病毒IAP重复8ephrin-B1假定蛋白质FLJ10342DnaJ(Hsp40)同系物；亚家族A；成员3溶血磷脂酶I小酸性蛋白质糖皮质激素受体结合因子1层粘连蛋白；β2(层粘连蛋白S)线粒体核糖体蛋白质L22CGI-111蛋白质染色体11开放阅读框15假定蛋白质FLJ20534环指蛋白14DnaJ(Hsp40)同系物；亚家族B；成员11天冬氨酸β羟化酶AL449243支持的假定基因Tax互作蛋白质1Bcl-2相关转录因子雌激素相关受体β样1假定蛋白质MGC3196甘露糖受体；C型1   103.2077145.5748102.5299190.27199.29429258.939692.56943213.1801187.7102367.7706251.3679122.8828113.906227.1041357.6112223.9793156.8451125.0717114.6952158.6983144.343870.02507227.9827181.8446101.2251167.5049351.772997.16912567.7076164.857277.30638   18410816313611718015830616323212610917220437428414715215117616111024717586.521940311784.6169100   187.5574187.5756187.7565188.0843188.1006188.3175188.3656188.8314188.8801188.9048189.0052189.5198189.7648189.9354190.1833190.2397190.439190.5787190.6578190.6804190.6944191.0561191.1542191.2168191.3988191.4831191.7684191.9499192.0982192.4133192.4612   158.2861146.9084150.9471171.4862134.7877209.0492146.1954235.9636179.8162262.9597188.6409140.4039158.4309206.8756307.2824232.7223164.6255155.8763152.156175.2567165.3815123.5579221.9109182.7428126.3618192.7801315.6313135.533281.455175.4765123.4215   8.62E-013.66E-018.73E-01-1.67E-029.22E-01-4.59E-011.02E+00-1.75E-018.96E-03-9.61E-01-4.11E-016.25E-017.36E-01-2.58E-01-9.11E-01-2.36E-012.80E-016.08E-017.33E-012.65E-014.02E-011.45E+00-2.54E-017.25E-029.19E-011.93E-01-8.75E-019.82E-01-1.56E+002.23E-011.32E+00   8.35E-01-4.36E-016.65E-01-4.83E-012.36E-01-5.25E-017.68E-015.21E-01-2.05E-01-6.63E-01-1.00E+00-1.75E-015.91E-01-1.58E-016.48E-023.42E-01-9.75E-022.81E-013.98E-011.52E-011.59E-016.46E-011.13E-01-5.40E-02-2.27E-013.89E-011.97E-012.74E-01-2.75E+003.72E-023.78E-01   1111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P19012Q14738O95152P78426Q14790P07711P32942Q9NWS0Q9NWZ5O75792P05141Q9NX38Q9Y682P78381Q9UMP5Q9P0Q0Q9UBQ3P27540Q9Y2W1P82267P00918Q9Y663Q9NX40P50222Q13610P49591   L04ab6C16cd1F04cd4A09cd3P14ab3N13ab4B02ab6L18ab2F13gh2O06gh2D15cd6I04ab2K22gh2A18cd8C02cd4B23ef3C15ef3M12cd7D22ab2F03cd5E15ab4C16ab3E07cd6K18gh2L09ab7C16cd7B12cd2  角蛋白15蛋白质磷酸酶2；调节亚基B(B56)；δ同工型小泡运输蛋白质NK6转录因子同系物A(果蝇)半胱天冬酶8；凋亡相关半胱氨酸蛋白酶组织蛋白酶L细胞间粘附分子3ATP酶；Na+/K+转运；α3多肽假定蛋白质FLJ20643尿嘧啶核苷激酶样1核糖核酸酶HI；大亚基溶质载体家族25(线粒体载体；腺嘌呤核苷酸转位分子)；成员5假定蛋白质FLJ20457sec22同系物溶质载体家族35(UDP-半乳糖转运蛋白)；成员2复制起始区蛋白质(60kD)假定蛋白质HSPC228聚胺调节因子1芳烃受体细胞核转运蛋白甲状腺激素受体相关蛋白质；150-kD亚基接头相关蛋白质复合物1；σ1亚基碳酸酐酶II硫酸乙酰肝素(氨基葡萄糖)3-O-磺基转移酶3A1卵巢癌免疫反应性抗原间充质同源异形盒2(生长抑制特异性同源异形盒)类似于酿酒酵母PWP1的核磷蛋白丝氨酰-tRNA合成酶   146.5632224.4642197.6319198.5291124.8603137.16140.3673188.937181.29108176.188100.3515454.9832140.7383193.7656276.1892270.4297129.6054189.4397239.4814160.2008198.6022283.4506259.052119.6155165.3048160.8948152.5268   13018319635328412114013110735899.631116127120717924117225824823117299.824722333169.6   192.6097192.7984192.9314193.0203193.1013193.1454193.1656194.2503194.4652194.4782194.705194.7577195.2668195.3918195.6585195.6957195.7376195.7465195.776195.7775195.7793195.9099196.1045196.1836196.5502196.7055196.7944   156.5003200.124195.3686248.2544200.6718150.5861157.6897171.3764127.6547242.9739131.5441320.3918165.7012220.1941226.4009214.9641188.838185.7473231.071201.3236208.571216.9569184.9847187.7106195.0839229.4375139.6467   3.94E-01-2.19E-01-3.47E-02-4.06E-026.29E-014.94E-014.61E-014.00E-021.26E+001.42E-019.56E-01-1.22E+004.72E-011.21E-02-4.97E-01-4.67E-015.95E-014.72E-02-2.91E-012.89E-01-2.07E-02-5.33E-01-4.02E-017.14E-012.50E-012.90E-013.68E-01   -1.69E-01-2.94E-01-1.53E-028.31E-011.19E+00-1.75E-01-8.57E-03-5.29E-013.99E-011.02E+00-1.12E-02-5.47E-011.95E-014.86E-01-4.14E-01-5.97E-018.96E-01-1.39E-011.07E-016.30E-012.20E-01-7.25E-01-1.38E+001.05E+004.34E-011.04E+00-1.13E+00   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P04554P02538Q13637P39086Q9H8F9Q99460Q9UKP6Q16589O95316O14545Q9Y249Q92794P36894P79525O14947Q12899Q9UIJ5P46821O60906P04040O60709Q14714P39687O75341Q9NUN1Q9UHR5   C19gh5N12ef6G23cd7J02ab3H20gh5L13ab8D20gh1A04ef5M03cd5A09cd7P03cd6K12cd4A12ab3L21ab7K04ab6K16cd3M24gh8A18ef2J11ab7P04cd1O18ab5B16cd5A02cd4F01cd4K16cd4D16gh3L22ef7  鱼精蛋白3角蛋白6ARAB32；成员RAS癌基因家族谷氨酸受体；离子移变的；红藻氨酸1假定蛋白质24432蛋白酶体(前体；macropain)26S亚基；非ATP酶；1G蛋白偶联受体14细胞周期蛋白G2核糖体蛋白质S6激酶；90kD；多肽5FLN29基因产物与酵母氮通透酶同源(候选的肿瘤抑制基因)锌指蛋白220骨形态发生蛋白受体；IA型MHC I类多肽相关序列B层粘连蛋白；β3(nicein(125kD)；缰蛋白(140kD)；BM600(125kD))包含三元基序的26锌指蛋白289；ID1调节锌指；包含DHHC结构域2微管相关蛋白质1B鞘磷脂磷酸二酯酶2；中性膜(中性鞘磷脂酶)过氧化氢酶发动蛋白1样sarcospan(Kras癌基因相关基因)酸性(富含亮氨酸)核磷蛋白32家族；成员ABRCA1相关蛋白质假定蛋白质FLJ11259转录调节子蛋白质   314.8934227.8925392.0158184.3318287.08298.3527213.371799.61434144.8234238.4292191.1146134.123149.2953120.8289360.8887188.693591.37228436.5048121.2356282.5771160.709885.33527378.724226.8272151.895152.5767225.1172   296277269210202228142214145288224179236125284250137452136281239220148108209196345   196.9835197.1759197.2609197.334197.402197.4025197.5131197.5658197.5662197.8936198.1049198.312198.4963198.5782199.2636199.2998199.4969199.696199.8286199.835199.9283199.9492200.1413200.186200.2666200.5435200.7483   269.3189233.9139286.1382197.2285228.8927241.22184.3366170.3526162.324241.5146204.4863170.3523194.5315148.0291281.2972212.5994142.4645362.7132152.4972254.5351199.8034168.4792242.1486178.3873187.1088182.989256.9591   -6.77E-01-2.09E-01-9.91E-019.83E-02-5.40E-01-5.96E-01-1.11E-019.88E-014.48E-01-2.69E-015.18E-025.64E-014.11E-017.17E-01-8.57E-017.89E-021.13E+00-1.13E+007.21E-01-5.00E-013.15E-011.23E+00-9.20E-01-1.80E-013.99E-013.94E-01-1.65E-01   -8.89E-022.80E-01-5.43E-011.88E-01-5.06E-01-3.89E-01-5.86E-011.10E+00-2.40E-032.74E-012.31E-014.13E-016.59E-014.53E-02-3.47E-014.05E-015.79E-015.01E-021.70E-01-7.08E-035.71E-011.37E+00-1.36E+00-1.07E+004.62E-013.60E-016.16E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9UMX3Q02297Q9BQ83O43491Q92922Q16099O95328Q06265Q01780Q9NPF9Q9P1U0Q13480O95205O76091Q9Y364P51116P49915Q9UHR3Q15007P24941P53634Q13123Q9NUT6Q9Y279O75319Q9NYH9Q9UNF0   D15gh8J05ef6A21gh6C22ab4N16cd1J11ef3B06gh4C15cd1K12gh6G07ef3B03ef4C02ab5O05gh1I11cd1F21ef2I14cd5H19cd4O04cd8O10cd5B03ef5L01ef7K03ef7P21gh3B23cd7H07cd3L08ef3M20cd7   BCL2相关卵巢杀手神经调节蛋白1假定蛋白质MGC5178红细胞膜蛋白质带4.1-样2SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族c；成员1谷氨酸受体；离子移变的；红藻氨酸4假定蛋白质628多肌炎/硬皮病自身抗原1(75kD)多肌炎/硬皮病自身抗原2(100kD)HeLa细胞周期蛋白依赖性激酶2互作蛋白质包含锌带状结构域；1GRB2相关结合蛋白质1C3H型锌指蛋白；类似于D.melanogaster muscleblind B蛋白质腈水解酶1DKFZP434J154蛋白质脆性X综合征；常染色体同系物2鸟嘌呤一磷酸合成酶鼻咽癌敏感性蛋白质维尔姆斯(氏)肿瘤1相关蛋白质细胞周期蛋白依赖性蛋白激酶2组织蛋白酶CIK细胞因子；HLA II负调节物假定蛋白质FLJ11151Ig超家族蛋白质双特异性磷酸酶11(RNA/RNP复合物1互作)肝细胞癌相关抗原66神经元中蛋白激酶C及酪蛋白激酶底物2   185.261689.51288302.7768265.5557251.3134200.0311253.2751167.3169196.9508251.6953110.7474171.5634136.7838194.24208.15215.9784175.5001120.0173237.107798.6080497.3314108.6134285.3106356.8489250.2151287.2586438.5503   17623439814419528824018227017015115026717932221311519625821477.9153565226205283349   200.9857201.3025201.3498201.5206201.571201.66201.6989202.2097202.2308202.5242202.7351203.065203.3797203.4317203.5516203.6388203.6534203.8212204.228204.3554204.771204.9565205.0219205.0366205.1456205.223205.53   187.4707175.0464300.7124203.6633216.0309229.9201231.7737183.9827223.1866207.9337154.8483174.7367202.2261192.2638244.4561210.8166164.6237173.3257233.0967172.2468126.6548155.5636351.7208262.6019220.2678258.6032331.0599   1.18E-011.17E+00-5.89E-01-3.98E-01-3.18E-011.17E-02-3.29E-012.73E-013.82E-02-3.14E-018.72E-012.43E-015.72E-016.67E-02-3.22E-02-8.49E-022.15E-017.64E-01-2.15E-011.05E+001.07E+009.16E-01-4.77E-01-7.99E-01-2.87E-01-4.85E-01-1.09E+00   -7.26E-021.39E+003.95E-01-8.84E-01-3.64E-015.26E-01-7.56E-021.25E-014.57E-01-5.70E-014.48E-01-1.98E-019.62E-01-1.17E-016.28E-01-2.12E-02-6.13E-017.09E-011.22E-011.12E+00-3.22E-014.95E-019.85E-01-6.59E-01-2.84E-01-1.99E-02-3.29E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O60437Q9NZN8Q14232O00142O60443O95406Q12841O15217P10645Q9HA66Q9Y439Q9Y386P53990O95865Q15834P18846Q14349Q9NVM5P12955Q99700Q9UJA2Q02246P48553Q99639Q9NQX5Q99799Q9BZV1Q03113   D03ab8N22cd8A18ab4C03ef5N15ab5J20cd5E24cd7B04ab5E01ab4D09gh5B06ef8G08ef2D21gh1O11ef3B21ef1I17cd7H05ab4A23cd7M08gh3N18ab7D14cd1E21gh3J21ef6E06cd2K03cd2N02gh4O08cd6J05gh7M19ab5 periplakinCCR4-NOT转录复合物；亚基2真核翻译起始因子2B；亚基1(α；26kD)胸苷激酶2；线粒体耳聋；常染色体显性5cornichon样卵泡抑素样1谷胱甘肽S转移酶A4嗜铬粒蛋白A(甲状旁腺分泌蛋白1)G蛋白β亚基样PRP31前mRNA加工因子31同系物(酵母)CGI-78蛋白质KIAA0174基因产物二甲基精氨酸二甲基氨基水解酶2免疫球蛋白λ样多肽2肝炎δ抗原互作蛋白质A转录激活因子1HLA-B相关转录物8假定蛋白质FLJ10637肽酶D脊髓小脑性共济失调2(橄榄体脑桥小脑共济失调2；常染色体显性；ataxin 2)染色体20开放阅读框155接触蛋白2(轴突)跨膜蛋白质1Ty 5同系物抑制子(酿酒酵母)神经增殖；分化和控制；1核RNA输出因子1包含UBX结构域的1鸟嘌呤核苷酸结合蛋白(G蛋白)α12   443.9882189.665273.7271124.7128122.4035181.718180.9305878.38055115.7467198.1992175.7234325.6509230.1187125.0105142.7367320.7647470.9776138.893898.19923133.8157191.0044134.2553108.0043148.0375225.1962188.0695205.4132127.7069140.2412   30122421014726413897.791.328319231024640115723022620617511519224031668.8238296206175236112   205.5879205.673205.7436205.9951206.3187206.4442206.5097206.6118206.8714206.9573207.0904207.7702207.9831208.0048208.1338208.1753208.3404208.5984209.0315209.0325209.0555209.227209.3915209.4168209.795209.8245209.9237209.9733209.9975   316.8358206.5153229.9659159.1674197.4327175.4375128.3877125.424201.8922199.1923230.9065259.7061279.676163.3476193.5142251.6031295.2222174.3142140.794178.2362213.1956219.8275128.7469198.4177243.5051201.225196.7655191.2074154.1344   -1.11E+001.17E-01-4.12E-017.24E-017.53E-011.84E-011.35E+001.40E+008.38E-016.24E-022.37E-01-6.48E-01-1.46E-017.35E-015.44E-01-6.24E-01-1.18E+005.87E-011.09E+006.43E-011.30E-016.40E-019.55E-015.00E-01-1.02E-011.58E-013.13E-027.17E-015.82E-01   -5.61E-012.41E-01-3.79E-012.35E-011.11E+00-3.95E-012.72E-012.20E-011.29E+00-4.27E-028.19E-01-4.06E-018.01E-013.29E-016.86E-01-5.06E-01-1.19E+003.37E-012.30E-015.20E-013.27E-011.23E+00-6.50E-016.84E-013.92E-011.30E-01-2.32E-018.86E-01-3.22E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P01130Q9UHN6Q99738Q9Y576P02304P01118P15924O43597P09622Q08257Q9UHY8P10646Q92685P34949Q9NPE9Q99853Q9HD41Q16625P45973Q9NVI9P37173Q9UKF7P16870P00374   B21ab6L11cd8A03cd3N03ef2B03gh6I08ab7K13ef7A19cd6I06ab3G16ef7J09cd7P23cd2L08cd5I13ab7M21ef8J24ef7C24gh4A10ab8L18ef6O12gh3O09ef7O21cd8J23ef7D16ab3   低密度脂蛋白受体(家族性高胆固醇血症)跨膜蛋白质2pinin；桥粒相关蛋白质锚蛋白重复序列及包含SOCS盒1H4组蛋白；家族2v-Ki-ras2 Kirsten大鼠肉瘤2病毒癌基因同系物桥粒斑蛋白(DPI；DPII)sprouty同系物2(果蝇)二氢硫辛酰胺脱氢酶(丙酮酸脱氢酶复合物E3组分；2-氧-戊二酸复合物；支链酮酸脱氢酶复合物)晶体蛋白；ζ(醌还原酶)肌束震颤及延长蛋白质ζ2(zyginII)组织因子通路抑制物(脂蛋白相关促凝剂抑制物)Not56(D.melanogaster)样蛋白质甘露糖磷酸异构酶HSPC055蛋白质forkhead盒B1CHMP1.5蛋白质occludinchromobox同系物5(HP1α同系物；果蝇)假定蛋白质FLJ10707转化生长因子；β受体II(70-80kD)视网膜变性Bβ羧肽酶E二氢叶酸还原酶   301.1179182.3012200.7164121.113981.15302209.4177249.9083119.5051346.3029514.699886.8735596.8869195.2017102.228191.56792141.4272280.2988859.5688164.9514136.0971112.4415333.606181.85341148.8142   39413020476.219123926315523230195.145821713515710523033812413620828713759.6   210.369210.5088210.6944210.8606210.8651211.0234211.0334211.0573211.1679211.6448211.8371212.0146212.2397212.3424212.3544212.4773212.8608212.9222213.1315213.1484213.3211213.5389213.5973213.6217   301.7776174.2344205.0214136.0527161.1406219.9522241.3819161.8627263.2128342.4839131.2705422.403208.1394149.8251153.7649153.0918241.047470.2634167.3186161.8885178.0564277.9863144.0377140.6638   -5.17E-012.08E-017.00E-028.00E-011.38E+001.10E-02-2.44E-018.21E-01-7.14E-01-1.28E+001.29E+00-1.49E+001.21E-011.05E+001.21E+005.87E-01-3.97E-01-2.01E+003.70E-016.47E-019.24E-01-6.44E-011.38E+005.22E-01   3.87E-01-4.89E-012.10E-02-6.69E-011.24E+001.93E-017.48E-023.75E-01-5.77E-01-7.73E-011.31E-01-3.81E-011.53E-014.00E-017.81E-01-4.25E-01-2.85E-01-1.35E+00-4.13E-013.42E-038.90E-01-2.18E-017.40E-01-1.32E+00   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P19957O75962P16050Q9Y3D2O00505Q9NZD8P46937P53384Q9UI28Q14651P10914P21281P53701Q9Y2B1Q14166Q15738Q16586Q9Y6J8Q9H5F2Q05655Q9NXU7O15498Q92664Q9Y223O95816Q9H0K5Q9BTJ1   M04ab8J24cd2C24ab2N14cd7J16ab6N15ef1G10cd6O05ab7K10ef4O20ab8K01ef6A03ab3G19ab6C18ef3D23ef8B09ef4I06cd1L05ef2P17gh5E02cd1M03gh3P21cd6F07ab4N03cd5E21ab3A21gh8C03ef2   蛋白酶抑制剂3；皮肤源性(SKALP)三功能性结构域(PTPRF互作)花生四烯酸15-脂肪加氧酶菌毛蛋白样转录因子karyopherinα3(importinα4)酸性簇集蛋白33Yes相关蛋白质1；65kD核苷酸结合蛋白质1(MinD同系物；大肠杆菌)AD-003蛋白质丝束蛋白1(I同工型)干扰素调节因子1ATP酶；H+转运；溶酶体(空泡质子泵)；β多肽；56/58kD；同工型2全细胞色素c合酶(细胞色素c血红素裂合酶)跨膜蛋白质5KIAA0153蛋白质NAD(P)依赖性类固醇脱氢酶样；H105e3sarcoglycan；α(50kD抗肌萎缩蛋白相关糖蛋白)map激酶磷酸酶样蛋白质MK-STYX假定蛋白质FLJ23499蛋白激酶C；δ假定蛋白质FLJ20048SNARE蛋白质Ykt6普通转录因子IIIAUDP-N-乙酰葡萄糖胺-2-差向异构酶/N-乙酰甘露糖胺激酶BCL2相关athanogene 2假定蛋白质DKFZp434H0115核糖体蛋白质S27样   202.9357233.7849288.5504200.9397358.8945222.816219.0427272.4995120.4834517.7448310.699299.07251.8825103.4737332.5834253.061358.221275.0054204.1242419.7056240.4802188.9561318.1862207.31184.7224193.1934132.1497   58219787.322431322326822314730339563841512327617112932633229723524219329594.2324411   213.9068213.9409213.9824214.0069214.0819214.2958214.3846214.5051214.7067214.7993214.9514215.0012215.1177215.2492215.4465215.5558215.8058215.9987216.1178216.1184216.1338216.7243216.7575217.1156217.4827217.6924218.2702   333.0661215.0154196.6194213.0068295.4165220.0079233.924236.5867160.6424345.2493306.8604383.914293.8906147.2535274.7657213.0647234.3861272.4953250.8425310.8344230.6008215.7355242.5829239.9617132.1461244.8706253.7125   7.60E-02-1.28E-01-4.31E-019.09E-02-7.45E-01-5.62E-02-3.10E-02-3.45E-018.34E-01-1.27E+00-5.32E-01-4.76E-01-2.28E-011.06E+00-6.26E-01-2.31E-01-7.31E-01-3.48E-018.24E-02-9.58E-01-1.54E-011.98E-01-5.54E-016.67E-021.36E+001.72E-017.24E-01   1.52E+00-2.45E-01-1.72E+001.57E-01-1.96E-016.21E-042.93E-01-2.91E-012.84E-01-7.72E-013.46E-011.09E+007.19E-012.50E-01-2.68E-01-5.69E-01-1.47E+002.48E-017.03E-01-5.00E-01-3.21E-023.54E-01-7.23E-015.11E-011.53E-017.45E-011.64E+00   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NRR5Q9Y5L3O75351O75443Q9H7X4O00255Q9BV94O14813P35269Q12891O15162Q14469P06241Q9BVG9Q9P0P9Q9UMF9Q03527P31153Q04741Q13153Q9Y388Q9HC14P30281Q9UFK2Q13011P09601Q9BVZ8Q13889P49703   J23gh4A13ab4K06cd5F07cd2K04gh7K22ab6D05gh3D10ab2D15ab4E08ef5L08gh1O08ab7P13ab4P17gh7K12ef2L14cd3L07ab8J15ab7D21ef1L22ef5H15ef2K17gh5O08ef5P05ef8O23ab4E20ef7P23gh8A11ab5P23ab2 染色体1开放阅读框6外三磷酸核苷二磷酸水解酶2K+转运缺陷抑制物1tectorinαKIAA1085蛋白质多发性内分泌瘤病I染色体20开放阅读框31aristaless同源异形盒(果蝇)普通转录因子IIF；多肽1(74kD亚基)透明质酸氨基葡糖苷酶2磷脂酰融合酶1毛状同系物(果蝇)有关SRC；FGR；YES的癌基因FYN磷脂酰丝氨酸合酶2假定蛋白质LOC51249真核翻译起始因子3；亚基9(eta；116kD)蛋白酶体(前体；macropain)26S亚基；ATP酶；1甲硫氨酸腺苷基转移酶II；α空孔同系物1(果蝇)p21/Cdc42/Rac1活化的激酶1(STE20同系物；酵母)CGI-79蛋白质线粒体核糖体蛋白质S35细胞周期蛋白D3DKFZP564K1964蛋白质烯酰辅酶A水合酶1；过氧化物酶体血红素加氧酶(去循环)1假定蛋白质FLJ14936普通转录因子IIH；多肽3(34kD亚基)ADP核糖基化因子4样   138.2192235.2745274.5936183.4591268.2576134.7209319.259226.3067243.8395331.3833440.6448151.2148106.4214225.5812290.4444207.6515441.6371245.2111240.3769243.198100.7214158.7783107.4859133.0476337.9818186.4519126.689112.1935125.6732   20131631115037211731632021331159725182.520043424228413418927718120016721027342512720291.2   218.4149218.4547218.6389218.7282218.7527218.9335219.2324219.2567219.8975220.4462220.6688221.0242221.2951221.5588222.6323222.6344222.6794222.7802222.791222.8583223.2467223.2594223.2751223.4229223.7187223.7447224.0692224.1653224.1896   185.8791256.4569267.9692184.2202286.2489156.9374284.912255.131225.4377287.6363419.5068207.739136.7385215.8454315.5648224.2505316.1666200.5541217.4148247.6258168.2598193.9429166.0499188.8934278.2904278.3661159.346179.5227147.0234   6.60E-01-1.07E-01-3.29E-012.54E-01-2.94E-017.01E-01-5.42E-01-4.57E-02-1.49E-01-5.88E-01-9.98E-015.48E-011.06E+00-2.60E-02-3.84E-011.01E-01-9.88E-01-1.38E-01-1.10E-01-1.26E-011.15E+004.92E-011.05E+007.48E-01-5.95E-012.63E-018.23E-019.99E-018.35E-01   5.40E-014.24E-011.78E-01-2.86E-014.71E-01-2.02E-01-1.37E-024.99E-01-1.98E-01-9.12E-024.39E-017.31E-01-3.67E-01-1.71E-015.78E-012.24E-01-6.36E-01-8.75E-01-3.46E-011.87E-018.44E-013.31E-016.39E-016.60E-01-3.07E-011.19E+006.71E-038.50E-01-4.62E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9GZU7P10253Q9Y3V5O14773P22061P14868Q14938O75968Q9H779Q9BX72O43563O15142Q9UJ41P05231Q9Y2H0Q9UJT9Q9Y306Q9Y6A6O75300P51798Q14839O60299Q9Y6F1O15212Q9Y2W2Q9UKN5   G11gh4M22ab3B18ef8P17ef7G13cd1K21ab4D16ef6P21ef3C15gh6C02gh8G24cd1D17ab2K17ef4F21ef7G24ef8E15cd8O23ef2N04ef3K18cd2L03ef1C21ab4O18gh1H03ab2E04ef3J14ef2O03cd8   核LIM互作物互作因子葡糖苷酶；α；酸性(蓬佩病；糖原贮积病II型)假定蛋白质DKFZP586F1318蜡样脂褐质沉积症；神经元2；晚期婴儿(詹-比二氏病)蛋白质-L-异天冬氨酸(D-天冬氨酸)O-甲基转移酶天冬氨酰-tRNA合成酶核因子I/X(CCAAT结合转录因子)pannexin 1假定蛋白质MGC2821IFP38溶质载体家族22(有机阳离子转运蛋白)；成员1样反义ARP2肌动蛋白相关蛋白质2同系物(酵母)推断的Rab5GDP/GTP交换因子同系物白细胞介素6(干扰素；β2)KIAA0964蛋白质F-盒及富含亮氨酸重复蛋白质7pelota同系物(果蝇)转录因子(p38互作蛋白质)核糖体结合蛋白质1同系物180kD(狗)氯离子通道7染色质域解旋酶DNA结合蛋白质4KIAA0552基因产物ADP核糖基转移酶(NAD+；多聚(ADP-核糖)聚合酶)样3HLA II类区表达的基因KE2WW结构域结合蛋白质11包含PR结构域4   305.5546187.3998303.8477169.6468118.1783117.194694.58773215.9189138.4597168.9682133.7352250.3086121.9096240.2349279.6086287.9128146.8037174.542598.67954278.4282104.8847132.5981248.9844250.113335.0512252.6208   15015642621416378.184.921631317214921516567331029419017173.728216133739929230480.6   224.2596224.2782224.4103224.4535224.5569225.0996225.3458225.5368225.8086225.8249225.8428226.0552226.5205226.529226.545226.762226.8083226.9539227.0651228.319228.322228.426228.5355228.5629228.6314228.639   226.5474189.0733318.1897202.7117168.6387140.1468134.9545219.072225.7323188.9468169.4168230.3093171.2118379.972271.9604269.5315187.7391190.8287133.1515263.0106164.8091232.6614292.1577256.7661289.1386187.2825   -4.46E-012.59E-01-4.37E-014.04E-019.26E-019.42E-011.25E+006.29E-027.06E-014.18E-017.56E-01-1.47E-018.94E-01-8.48E-02-3.04E-01-3.44E-016.28E-013.79E-011.20E+00-2.86E-011.12E+007.85E-01-1.24E-01-1.30E-01-5.51E-01-1.44E-01   -1.03E+00-2.69E-014.89E-013.35E-014.66E-01-5.85E-01-1.55E-01-1.06E-031.18E+002.61E-021.53E-01-2.22E-014.38E-011.49E+001.48E-012.98E-023.69E-01-2.97E-02-4.21E-011.98E-026.20E-011.35E+006.80E-012.22E-01-1.42E-01-1.65E+00   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q00978Q9UHY0Q9Y248O96019P10276Q9BUC7Q9HAC1Q93078P08572P15056Q15543O14901P51965Q9Y3R2O94829Q92859Q12846P01286Q9UH92O75323Q9UQ33Q9Y3A7Q9Y2Z0P56211P21127Q07866Q9BTI3   C24cd6L08ef1L13ef2E21ab2K19ab8P22gh8D01gh5M18gh6N22ef6G10ef5J15cd2J05cd3N10gh8O13cd3G04cd8G10gh1M13ab8O02cd2G15ef1L01cd8P09ab5P07ef2A17ef2A17cd7F16ab2O13ef1B23ab7H11ef8   干扰素刺激的转录因子3；γ(48kD)HP1-BP74HSPC037蛋白质BAF53视黄酸受体；α假定蛋白质MGC4172praja1H2B组蛋白家族；成员H胶原；IV型；α2v-raf小鼠肉瘤病毒癌基因同系物B1TAF13RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；18kDTGFB可诱导性早期生长反应2二磷酸二甲基烯丙基二磷酸异构酶2泛素缀合酶E2E 1(UBC4/5同系物；酵母)transportin-SRimportin 13neogenin同系物1(鸡)突触融合蛋白4A(胎盘)生长激素释放激素转录因子样4恶性胶质瘤扩增序列微管相关蛋白；RP/EB家族；成员2CGI-101蛋白质SKP1的G2等位基因抑制基因；酿酒酵母；同系物环AMP磷蛋白；19kD细胞分裂周期2样2驱动蛋白2(60-70kD)KIAA1068蛋白质   303.7171295.951292.39515228.9673250.0312136.4413143.4188179.965670.14126194.1803222.3129277.9069313.8915254.2693338.45160.8646153.0455323.5547237.6384172.7135178.3893101.7866402.1639184.6693276.9734159.1108254.5932228.7025   40426770.334512239897.520387.317426227725767321924724993.2263195168134210256386304408230   228.7768228.8435229.0541229.5696229.7466229.8471230.0154230.2553230.3868231.0687231.2695231.5621231.841232.1178232.2301232.3109232.6926232.9973233.028233.1639233.5843234.2195234.3057234.3223234.3401234.454234.5156234.5211   312.2774263.8122130.5748267.9206200.7048254.8265156.9785204.3058129.2665199.7155238.5733262.1749267.6704386.4499263.1006213.3188211.5326216.5887244.6261200.1328193.2783156.5563282.2981224.9662299.2676232.4012299.1796231.0835   -4.09E-01-3.71E-011.31E+003.79E-03-1.22E-017.52E-016.81E-013.56E-011.72E+002.51E-015.70E-02-2.63E-01-4.37E-01-1.32E-01-5.43E-015.30E-016.04E-01-4.74E-01-2.83E-024.33E-013.89E-011.20E+00-7.79E-013.44E-01-2.41E-015.59E-01-1.19E-013.62E-02   4.13E-01-1.50E-01-3.95E-015.92E-01-1.03E+001.55E+00-5.57E-011.72E-013.15E-01-1.59E-012.38E-01-4.43E-03-2.87E-011.40E+00-6.31E-016.17E-017.01E-01-1.80E+001.47E-011.72E-01-8.78E-023.93E-01-9.34E-014.71E-014.81E-019.32E-016.82E-018.33E-03   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9H2J4Q9NXE5Q92572Q9NXT6O15321O15383O60403P49354P48039O43562Q9HC89P00790Q9NVP1Q9UBN1P35659P54252Q14152Q9Y314Q9NRC7P02533O60907P43155Q15077Q12840P26599Q9Y316P24394   E11gh6E10gh2E17ab4K05gh2F05cd6F07cd6B06cd8K24ab4B07ef6C08ab8N24ef8M13ef1G01cd6F23ef3M22cd3N09ef6L12cd3E16ef2E23ef3N02ef6J19cd2B16ab3H08ab8I06ab7A05cd3M11ef2O18ab6   假定蛋白质MGC3062假定蛋白质FLJ20296接头相关蛋白质复合物3；σ1亚基FtsJ同系物3(大肠杆菌)跨膜9超家族成员1HIV-1Tat互作蛋白质2；30kD嗅觉感受器；家族10；亚家族H；成员2法呢酰基转移酶；CAAX盒；α褪黑激素受体1A溶质载体家族22(有机阳离子转运蛋白)；成员1样钙蛋白酶10胃蛋白酶原5；I组(胃蛋白酶原A)DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽18(Myc调节)钙通道；电压依赖性；γ亚基4DEK癌基因(DNA结合)马-约病(脊髓小脑性共济失调3；橄榄体脑桥小脑共济失调3；常染色体显性；ataxin 3)真核翻译起始因子3；亚基10(θ；150/170kD)eNOS互作蛋白质sirtuin沉默交配型信息调节2同系物6(酿酒酵母)角蛋白14(单纯型大疱性表皮松解症；Dowling-Meara；Koebner)转导素(β)样1X连锁肉毒碱乙酰转移酶嘧啶受体P2Y；G蛋白偶联；6驱动蛋白家族成员5A多聚嘧啶串结合蛋白质1C21或f19样蛋白质白细胞介素4受体   238.7573193.837986.23952254.7485295.1129402.8554237.7465173.9344305.0267115.4101212.0136256.00978.40555269.971980.02159156.7549364.5131123.3313136.0486203.4102175.9553288.355389.9746238.3605160.4912450.6398309.5199   2563992092772274442621932081252422668936077.8274268219328190171190248282345327330   235.0353235.1468235.2813235.4026235.695235.7849235.906235.9155236.1249236.1587236.247236.6918236.7778237.0557237.1934237.2775237.302237.3058237.5194237.6951237.7396237.8908238.1475238.2407238.4238.5981238.6201   243.2412275.9024176.703255.685252.5647360.7235245.2774201.1077249.7986158.9844230.2337253.0491134.724289.0967131.6712222.5126289.959193.3594233.7238210.4458194.8701238.6829292.1056252.8959247.8557338.8101292.7071   -2.27E-022.79E-011.45E+00-1.14E-01-3.24E-01-7.73E-01-1.12E-024.40E-01-3.69E-011.03E+001.56E-01-1.13E-011.59E+00-1.88E-011.57E+005.98E-01-6.19E-019.44E-018.04E-012.25E-014.34E-01-2.78E-01-7.12E-01-7.25E-045.71E-01-9.17E-01-3.75E-01   1.00E-011.04E+001.27E+001.20E-01-3.79E-011.39E-011.41E-011.54E-01-5.51E-011.20E-011.93E-015.77E-021.83E-014.16E-01-4.06E-028.03E-01-4.43E-018.31E-011.27E+00-9.66E-02-4.19E-02-6.03E-01-6.52E-012.43E-011.10E+00-4.62E-019.24E-02   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P32418P42694O60755Q16204Q12980P08559Q9Y2U9Q9Y2T2Q13105Q9H1J1Q08752P38159Q9Y337P25445Q9BZH1O43633Q99536P24557O75369P50453P35680Q03924Q9NRQ5Q99867Q9H682O00148   J22gh1N01ef3L09cd3A18cd4N15cd7N16ab7K02ef3P17cd7K10cd3J12gh5E01cd1F14ab7A12cd8A02ef6P02gh5O12ef4B03cd6N11cd1G16ab4H10ab8O18cd1I01gh7F17gh4G12gh7B19gh7N12cd5   溶质载体家族8(钠/钙交换物)；成员1具有锌指结构域的解旋酶促生长激素神经肽受体3DNA片段；单拷贝；探针pH4(转化序列；甲状腺-1；α珠蛋白集簇端粒处保守基因丙酮酸脱氢酶(硫辛酰胺)α1宿主细胞因子同系物接头相关蛋白质复合物3；μ1亚基锌指蛋白151(pHZ-67)类似于酵母Upf3；变体A肽酰脯氨酰异构酶D(亲环蛋白D)RNA结合基序蛋白质；X染色体激肽释放酶5肿瘤坏死因子受体超家族；成员6跨膜4结构域；亚家族A；成员5推断的乳腺癌标志(32kD)小泡胺运输蛋白1血栓素A合酶1(血小板；细胞色素P450；亚家族V)细丝蛋白B；β(肌动蛋白结合蛋白质278)丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade B(卵清蛋白)；成员9肿瘤因子2；肝；LF-B3；变体肝细胞核因子锌指蛋白117(HPF9)FN5蛋白质微管蛋白；β多肽4；成员QA20结合的NF-κB活化2DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽39   171.4835165.7017162.6185192.0586183.7714375.1479127.5142336.9686177.9188154.12446.371342.4693215.5515102.3524350.8825308.4601222.8504326.4482331.6975439.8605235.5021257.8571361.924376.7361205.6095259.196   134146268225174206154395243183203176312215212232400236459370174301325247365140   238.7225238.7561238.7669238.8166238.9231239.4879239.623239.6299240.018241.0316241.0389241.0429241.2144241.2257241.5154241.573241.6698241.6841241.7672242.4005242.5943242.7729242.8257243.6773243.7949244.0023   181.3894183.6122223.2368218.6477198.8702273.612173.6438323.8714220.1539192.8261296.8872253.2584256.4089186.0304268.2725260.7188288.1564268.1689344.1714350.7941217.2497267.2646309.8867289.1694271.5091214.3036   4.77E-015.27E-015.54E-013.14E-013.79E-01-6.48E-019.10E-01-4.92E-014.32E-016.45E-01-8.89E-01-5.07E-011.62E-011.24E+00-5.39E-01-3.53E-011.17E-01-4.34E-01-4.56E-01-8.60E-014.28E-02-8.70E-02-5.76E-01-6.29E-012.46E-01-8.71E-02   -3.56E-01-1.79E-017.22E-012.29E-01-7.95E-02-8.63E-012.70E-012.29E-014.47E-012.50E-01-1.13E+00-9.58E-015.36E-011.07E+00-7.24E-01-4.10E-018.44E-01-4.66E-014.69E-01-2.49E-01-4.40E-012.24E-01-1.56E-01-6.08E-018.28E-01-8.92E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
Q9UG51O75175Q9GZQ8P19438Q9NRR8O95162O95279Q9NTW4Q9NWM9P40121Q92466O43365Q9NVJ7Q9NVY5Q9BY40Q9NZE2P29275Q9NZE0Q03111Q08499Q15628Q9Y657Q9UHQ1   F11cd8N05ef3F12cd8C05gh2A04ef6O04gh4N10ef8J22cd3N21ef8H21gh2P23ab5I04ab3K05gh7O02gh3H08ef7G12gh8O06ef2K11ab2P22ef1N03ab7G21ef6A20ef6C07cd7I09cd8   TCF3(E2A)融合配偶体(儿童白血病)分裂后期促进复合物亚基10CCR4-NOT转录复合物；亚基3微管相关蛋白质1A/1B轻链3肿瘤坏死因子受体超家族；成员1ACdc42的小蛋白效应子1过氧化物酶体短链醇脱氢酶钾通道；亚家族K；成员5(TASK-2)DKFZP564A2416蛋白质假定蛋白质FLJ20730加帽蛋白(肌动蛋白丝)；凝溶胶蛋白样损伤特异性DNA结合蛋白质2(48kD)同源异形盒A3DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽32血清学决定的结肠癌抗原3CDA11蛋白质假定蛋白质LOC51321腺嘌呤核苷A2b受体包含WW结构域的带有卷曲螺旋区的衔接蛋白骨髓/淋巴或混合性白血病(三空腔同系物；果蝇)；已易位到；1磷酸二酯酶4D；cAMP-特异性(磷酸二酯酶E3 dunce同系物；果蝇)通过死亡结构域相关的TNFRSF1Aspindlin核prelamin A识别因子   170.7519274.4079230.1579261.5987233.3188338.2133154.9486274.3417403.4188121.538452.200699.17314132.7369336.1927182.4596141.076376.41026354.511582.72809225.1377125.5177214.1641217.9487312.9614   29533125339519732910812721920741422019628417813113519171.116292.9250202303   244.0153244.0324244.0384244.0725244.3384244.5729244.9155244.9972245.1953245.69245.8846246.0478246.2071246.3831246.7633246.8975247.0025247.0615247.6094247.8275248.1727248.2613248.4185248.5926   236.7141283.0875242.329300.1702224.9565303.9389169.1352215.5542289.1446191.4607370.7982188.2839191.5647288.7892202.4155173.0132152.875264.0659133.8159211.7891155.5405237.3623222.9201288.0624   5.15E-01-1.69E-018.45E-02-1.00E-016.66E-02-4.68E-016.60E-01-1.63E-01-7.18E-011.02E+00-8.79E-011.31E+008.91E-01-4.48E-014.36E-018.07E-011.69E+00-5.21E-011.58E+001.39E-019.83E-012.13E-011.89E-01-3.32E-01   7.91E-012.70E-011.35E-015.94E-01-2.43E-01-3.97E-02-5.27E-01-1.11E+00-8.83E-017.69E-01-1.26E-011.15E+005.60E-01-2.44E-01-3.55E-02-1.06E-018.23E-01-8.95E-01-2.18E-01-4.71E-01-4.34E-012.21E-01-1.07E-01-4.84E-02   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P17980P45877O95340Q9H9Z7O15172P01298Q13395O15551P55060O43286P04424Q9NWR5Q9BUN8P49760Q9UEG3Q9P0Y6Q92535Q00577O75717P04278P51124P15259Q12893P57738P24863Q9Y370Q9HD89O14807Q13435Q9UMY4O43929Q9BZQ1   H24ef6I19ab8A23cd5F18gh5E11cd4F05ab8J17cd2G23ab4G20ef6E13ab3J10ab2C10gh3M21gh6G01ab4E01gh7N07ef1M06ab8A24gh7L21ab2L09cd1G19ab5P04ab7O13cd7A11gh2O22ef5H03ef2E04gh4N04cd7I07cd7F19cd8C04ab8H14gh7   蛋白酶体(前体；macropain)26S亚基；ATP酶；3肽酰脯氨酰异构酶C(亲环蛋白C)3′-磷酸腺苷5′-磷硫酸合酶2假定蛋白质FLJ12448磷酸丝氨酸磷酸酶样胰多肽TAR(HIV)RNA结合蛋白质1claudin 3CSE1染色体分离1样(酵母)UDP-Gal：βGlcNAcβ1；4-半乳糖基转移酶；多肽5精氨琥珀酸裂解酶假定蛋白质FLJ20657假定蛋白质MGC3067CDC样激酶2myotubularin相关蛋白质3染色体3开放阅读框1磷脂酰肌醇聚糖；C类富含嘌呤元件结合蛋白质BAND-1蛋白质性激素结合球蛋白粒酶M(淋巴细胞met-ase 1)磷酸甘油酸变位酶2(肌肉)PL6蛋白质T细胞白血病易位改变的基因细胞周期蛋白CCGI-60蛋白质炎症区域发现的3肌肉RAS癌基因同系物剪接因子3b；亚基2；145kD分选连接蛋白12(复制)起点识别复合物；亚基4样(酵母)染色体1开放阅读框25   331.1488165.0716110.9876158.5794321.9068544.0034260.7056279.9519322.1588316.581594.9833171.9643165.690469.23701367.623268.1158218.2502839.6225.9974215.6067108.9072333.2442174.3077166.5683668.8634153.6349189.8748105.1243270.3354178.8659267.5605219.6632   19316988.627929119423425027646826925217597.1236256172273250196114363280232523157182181268227354362   248.6286248.9851249.0622249.1478249.3629249.376249.3777249.4618249.5903249.8072250.046250.1961250.2847250.3266250.553250.6098250.9192251.0214251.1522251.1944251.2498251.6606252.0241252.2165252.3632252.5036252.7224252.8147252.8473253.0136253.265253.5183   257.496194.3167149.5355228.8009287.4495329.1527248.0711259.744282.6907344.9578371.2796224.6496197.0059138.8925284.5589258.2636213.6071454.6488242.2724221.0173158.1827315.8301235.3565217.0429481.4089187.603208.2163179.5238263.6077219.6698291.5955278.4192   -4.13E-015.93E-011.17E+006.52E-01-3.68E-01-1.13E+00-6.41E-02-1.66E-01-3.68E-01-3.42E-01-1.25E+005.41E-015.95E-011.85E+00-5.53E-01-9.74E-022.01E-01-1.74E+001.52E-012.20E-011.21E+00-4.05E-015.32E-015.99E-01-1.41E+007.17E-014.13E-011.27E+00-9.65E-025.00E-01-7.92E-022.07E-01   -7.81E-013.30E-02-3.26E-018.13E-01-1.45E-01-1.49E+00-1.55E-01-1.64E-01-2.21E-015.65E-01-1.15E+005.50E-017.92E-024.88E-01-6.42E-01-6.63E-02-3.46E-01-1.62E+001.44E-01-1.36E-017.09E-021.22E-016.82E-014.80E-01-3.55E-012.82E-02-6.07E-027.81E-01-1.45E-023.45E-014.04E-017.21E-01   11111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P55042Q92870P33778Q9ULZ3Q13485Q9H684Q9H7F8Q92508Q9UM47P18084Q99462O75619Q92733Q15796P15291Q99417P06732P50570Q9Y5A9Q92841P51808O95758P32970O75689P55072P47813Q15532Q15813   K03ef5K18ef1C19gh7K22cd8A20ef5C24gh5O06gh7B17gh1C15ab8E17ef7K22gh6J10ef7K07cd1H21ab7E07ab3I07cd8D09ab4K13ab5F20ef2B17cd6B22cd2H23cd5I15ef5K21cd7O06cd4A16ab4J03cd2M19cd2   糖尿病关联的Ras相关淀粉状蛋白β(A4)前体蛋白质结合；家族B；成员2(Fe65样)H2B组蛋白家族；成员F包含CARD的凋亡相关speck样蛋白质MAD；母抗decapentaplegic同系物4(果蝇)锌指蛋白335假定蛋白质FLJ20958KIAA0233基因产物Notch同系物3(果蝇)整联蛋白；β5泛素缀合酶E2G1(UBC7同系物；线虫)RNA解旋酶相关蛋白质乳突肾细胞癌(易位相关)MAD；母抗decapentaplegic同系物2(果蝇)UDP-Gal：βGlcNAcβ1；4-半乳糖基转移酶；多肽1c-myc结合蛋白质肌酸激酶；肌肉发动蛋白2高葡萄糖调节蛋白质8DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽17(72kD)t复合物相关睾丸表达1样1ROD1分化调节子1(裂变酵母)肿瘤坏死因子(配基)超家族；成员7蓟苦素；α1包含缬酪肽的蛋白质真核翻译起始因子1A滑膜肉瘤易位；染色体18微管蛋白特异性分子伴侣e   300.579476.07104169.4431255.9554163.1373326.6826190.1073241.185964.97745259.2818207.6691198.1059200.3207376.8422411.9325264.1386202.527248.1389359.385229.8916182.2992411.9888443.4158191.7263466.7034486.6493190.8535151.2337   51477.9391517181261258216132129179335260446403256127228371270245462456327363337212166   253.5279253.5714253.9554254.0856254.1546254.3385254.7196255.0491255.0839255.1335255.2632255.6713256.1407256.2171256.9006256.9088257.2272257.2474257.3917257.9255257.9487258.1758258.4229258.6362258.8411259.0481259.1488259.2747   355.8906135.8422271.5522342.2046199.4935280.5396234.2579237.2652150.552214.6124213.9424262.7733238.8334359.5423357.1444259.037195.4365244.4335329.2557252.4572228.2619377.5392386.0177259.1653362.8018360.7943220.5805192.1296   -2.46E-011.74E+005.84E-01-1.06E-026.40E-01-3.61E-014.22E-018.06E-021.97E+00-2.33E-022.98E-013.68E-013.55E-01-5.57E-01-6.81E-01-4.00E-023.45E-015.20E-02-4.82E-011.66E-015.01E-01-6.74E-01-7.79E-014.32E-01-8.50E-01-9.10E-014.41E-017.78E-01   7.73E-013.40E-021.21E+001.01E+001.51E-01-3.26E-014.40E-01-1.62E-011.02E+00-1.00E+00-2.15E-017.56E-013.76E-012.42E-01-3.31E-02-4.48E-02-6.78E-01-1.23E-014.59E-022.30E-014.24E-011.67E-014.11E-027.71E-01-3.63E-01-5.31E-011.50E-011.33E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P14373O14980P07942P53041Q07820P53816Q9P1C8P51966Q99739P35913P52756Q9NXX5Q14498P28069P51397Q9NUI8O00322P78368Q01081O43193Q9Y3B0Q9NV80Q9Y473Q9Y548Q13952P18615P33241O15116P50897Q9Y3A5   B08cd2G02cd3P20ef6C20cd1E12ef6E04cd7E09gh4O21cd3M03cd7N14ab7J24cd5K17gh3O06cd5A03ab8E20ab5C24gh7M09cd7I09ab4I22cd4J15ab5M03ef2H05gh3O18cd4L20gh2N15ef6K17cd3B23ef1C01ef4A11ab8F20gh8G12ef2   ret指形蛋白质exportin 1(CRM1同系物；酵母)层粘连蛋白；β1蛋白质磷酸酶5；催化亚基骨髓细胞白血病序列1(BCL2相关)HRAS样抑制基因3假定蛋白质PRO2577泛素缀合酶E2L 3pim-2癌基因磷酸二酯酶6B；cGMP特异性；rod；β(先天性静止性夜盲3；常染色体显性)RNA结合基序蛋白质5假定蛋白质FLJ20004包含RNA结合区(RNP1；RRM)2POU结构域；1类；转录因子1(Pit1；生长激素因子1)死亡相关蛋白质推断的甲基转移酶uroplakin 1A酪蛋白激酶1；γ2U2(RNU2)核内小RNA辅助因子1G蛋白偶联受体38CGI-105蛋白质WD重复结构域12锌指蛋白175假定蛋白质DJ167A19.1核转录因子Y；γRD RNA结合蛋白质淋巴细胞特异性蛋白质1Lsm1蛋白质棕榈酰蛋白质硫酯酶1(蜡样脂褐质沉积症；神经元1；婴儿)MADP-1蛋白质CGI-97蛋白质   282.5757239.496571.03574272.5094362.5007606.0957238.9909148.3528178.694199.3654280.6537130.163196.0463261.1822348.1009157.3551223.5286211.1048138.153369.57316174.5026178.5139141.3794233.5442241.7469237.019994.80267344.8146126.6311134.6124469.4567   27020792.419624355820524327417323019721620631232929527291.3206177279275240354242131479142228544   259.3599259.7187259.7579259.8136260.0329260.1565260.3147260.3185260.4482260.5708261.0637261.2642261.5829261.7763261.9342262.0287262.0828262.1137262.1811262.301262.5458262.6286263.1099263.4412263.6055263.7642264.242264.6979264.8236264.9564265.0744   270.5765235.5264141.0764242.7533288.4688474.8201234.8631217.1092237.5556210.8879257.2441196.0576224.4664243.064307.4499249.4637260.1175248.257163.878179.1305204.6742239.9609226.3406245.7773286.4173247.7362163.4955362.8572177.9418209.3298426.2946   -1.24E-011.17E-011.87E+00-6.88E-02-4.79E-01-1.22E+001.23E-018.11E-015.44E-013.86E-01-1.04E-011.01E+004.16E-013.28E-03-4.10E-017.36E-012.30E-013.12E-019.24E-011.91E+005.89E-015.57E-018.96E-011.74E-011.25E-011.54E-011.48E+00-3.81E-011.06E+009.77E-01-8.25E-01   -6.68E-02-2.08E-013.80E-01-4.76E-01-5.78E-01-1.19E-01-2.19E-017.10E-016.14E-01-2.07E-01-2.87E-015.96E-011.38E-01-3.41E-01-1.57E-011.06E+003.99E-013.63E-01-5.98E-011.56E+002.03E-026.43E-019.57E-014.14E-025.50E-013.25E-024.71E-014.74E-011.69E-017.63E-012.14E-01   1111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9BVT1Q9UM44Q9UGC7P49146P54687O60884Q9NVC6O43399O75880P49406Q9NYK5O15428O14842O15262Q9NP61O15491O75390P57088Q9NRY6O15403Q9BPZ5P10301Q9P018Q9Y4H2Q9UJX3Q9H5X0Q92820   G03gh6E10cd7A05gh3G01ab8I03ab3O09cd6J01cd7G06cd2K22cd2F01gh1E15gh2P18cd2K04ab5I06cd6J01ef3P22cd5P01ab5I12gh3K06gh4E05cd5K09gh6P01cd2A20gh7A08ef8L10cd3F04ef2O01gh6H23cd4   白细胞受体集簇(LRC)成员5HERV-H LTR相关2类似于原核型I类肽链释放因子神经肽Y受体Y2支链转氨酶1；细胞质DnaJ(Hsp40)同系物；亚家族A；成员2Sp1转录活化所需辅因子；亚基6(77kD)肿瘤蛋白质D52样2SCO细胞色素氧化酶缺陷同系物1(酵母)线粒体核糖体蛋白质L19线粒体核糖体蛋白质L39蛋白质(肽酰-脯氨酰顺/反异构酶)NIMA互作1样G蛋白偶联受体40环指蛋白3ADP核糖基化因子GTP酶活化蛋白质1WD重复蛋白质柠檬酸合酶假定蛋白质FLJ10525磷脂酰融合酶3溶质载体家族16(一元羧酸转运蛋白)；成员6假定蛋白质MGC3123相关RAS病毒(r-ras)癌基因同系物HLA-B相关转录物4HSPC142蛋白质胰岛素受体底物2分裂后期促进复合物亚基7假定蛋白质MGC2941γ-谷氨酰水解酶(缀合酶；folylpolyy-谷氨酰水解酶)   282.5457180.7238289.9756222.0084103.4218330.3137183.0562283.4636156.7184577.0339473.2712185.1313222.6002243.845344.6989254.6166656.561377.5067272.0774384.2992127.3745314.4978168.0802196.1899297.029210.2906333.583478.13783   32811936257.893.836715034811735344924917040117535531234933473.5286204234346329204308101   265.5443265.5625265.7778265.9266266.0547266.0819266.1556266.2168266.2419266.3918266.7642267.1449267.4241267.4275267.443267.6951268.0488268.1833268.2248268.3423268.7928268.8367269.0656269.5447270.4962270.642270.759271.925   291.9599188.5666306.0797181.9126154.4299321.0577199.8392299.1558179.8238398.6973396.3322233.6377219.8563304.1323262.4544292.4461412.1526331.588291.4542242.0422227.363262.4726223.8166270.6564298.8227228.4449304.1289150.359   -8.95E-025.55E-01-1.26E-012.60E-011.36E+00-3.12E-015.40E-01-9.06E-027.65E-01-1.12E+00-8.27E-015.29E-012.65E-011.33E-01-3.66E-017.23E-02-1.29E+00-4.93E-01-2.06E-02-5.18E-011.08E+00-2.26E-016.79E-014.58E-01-1.35E-013.64E-01-3.01E-011.80E+00   2.14E-01-5.98E-013.22E-01-1.94E+00-1.41E-011.51E-01-2.84E-012.95E-01-4.28E-01-7.10E-01-7.61E-024.25E-01-3.93E-017.18E-01-9.76E-014.80E-01-1.07E+00-1.13E-012.96E-01-2.39E+001.17E+00-6.24E-014.79E-018.20E-011.47E-01-4.10E-02-1.15E-013.70E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9UKK3Q9NWC8O14965P50613Q9H1C4P21851Q9UGJ0P04035Q9UKY7O95478Q9Y3W9Q9Y325Q92854P16106O43143Q13547Q9H6F9Q9NX18O94764P82909Q9UI07P20337Q07960P49448Q9NX48Q9NV56   K15ab2N13gh2I07cd2B11ef5H08gh7E13ab4B14ef2D17ab6K03gh3B18gh1B16ef8A20ef2B09cd6O08gh6M05ab4L12ef6D11gh5M08gh2P03cd5N18gh8D18ef8M01ef5B22ab2P03cd7K08gh2J03gh3   ADP核糖基转移酶(NAD+；多聚(ADP-核糖)聚合酶)样1假定蛋白质FLJ10120丝氨酸/苏氨酸激酶6细胞周期蛋白依赖性激酶7(MO15同系物；非洲爪蟾；cdk活化激酶)unc-93同系物B1(线虫)接头相关蛋白质复合物2；β1亚基蛋白激酶；AMP活化的；γ2非催化亚基3-羟基-3-甲基戊二酰辅酶A还原酶假定蛋白质H41假定蛋白质YR-29sentrin/SUMO特异性蛋白酶3CGI-36蛋白质sema结构域；免疫球蛋白结构域(Ig)；跨膜结构域(TM)及短胞浆结构域；(semaphorin)4DH3组蛋白家族；成员CDEAD/H(Asp-Glu-Ala-Asp/His)盒多肽15组蛋白脱乙酰基酶1假定蛋白质FLJ22313假定蛋白质FLJ20487RAN结合蛋白质9线粒体核糖体蛋白质S36小鼠热休克蛋白的可能直向同源物；70kDa 4RAB3B；成员RAS癌基因家族Rho GTP酶活化蛋白质1谷氨酸脱氢酶2假定蛋白质FLJ20442染色体20开放阅读框20   337.297315.7654139.2727286.8535348.8713338.7753425.3015242.9132643.0085248.2059220.4064346.618342.6474105.4744412.7015375.5725306.5811311.71256.3223261.4618199.8914214.8304219.98344.3683493.7568138.9543   4503011014235013735431692722213333381832213493722903942683431g9126218229601104   271.9944272.0013272.158272.2018272.3385272.4617272.5312273.2324273.736273.8047274.1753274.2434274.4146274.8424274.9731275.2293275.269275.6418275.8144275.8463276.061276.148276.184276.2751276.8343277.4945   352.9975296.1206170.6789327.4234374.1085328.1045413.4782228.5315396.2551247.5607275.7642319.4542266.8232200.5879345.6042340.9663290.6336327.1007266.5947293.6016225.0966205.8132237.9303283.2713457.1855173.6478   -3.10E-01-2.15E-019.67E-01-7.56E-02-3.57E-01-3.14E-01-6.42E-011.70E-01-1.23E+001.42E-013.15E-01-3.38E-01-3.20E-011.38E+00-5.86E-01-4.48E-01-1.55E-01-1.77E-011.06E-017.73E-024.66E-013.62E-013.28E-01-3.18E-01-8.35E-019.98E-01   4.15E-01-7.10E-02-4.69E-015.61E-015.22E-011.39E-013.51E-01-5.20E-01-1.24E+00-1.70E-015.94E-01-3.85E-02-9.02E-011.07E+00-2.41E-01-1.34E-02-8.00E-023.38E-016.24E-023.94E-01-4.00E-03-7.65E-01-1.55E-02-5.88E-012.83E-01-4.11E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O00154Q9UI70P26045Q9Y2A8Q9BZ89P35052Q9H0S9Q15654P51948Q13133Q9P0J9Q15546P28325O94985P48634Q9BRL6O94851Q9NW56Q9H6X6P41217P31512Q15425P40306Q9NWZ8P57073Q9Y450P04062O75065Q9ULX2Q99871   L21cd7B04ef1N17ab8C24ef3F08gh7J24ab4K21gh7I07ef7I09ab7B20cd5H22gh3G23cd8E09ab5O04ef8M03cd4O15gh7E06gh1E20gh3P19gh5N13ab7P04ab4H05cd2L05ab8O02gh2E22ef8H22cd6O08ab3E22gh1F09ef3C06ef4  脑脂酰辅酶A水解酶核仁蛋白质ANKT蛋白酪氨酸磷酸酶；非受体3型CD209抗原样磷脂酶A2；XII组磷脂酰肌醇聚糖1核受体结合因子2甲状腺激素受体互作子6menage atrois1(CAK装配因子)核受体亚家族1；H组；成员3巨人蛋白质单核细胞-巨噬细胞分化相关半胱氨酸蛋白酶抑制剂Dcalsyntenin 1HLA-B相关转录物2剪接因子；富含精氨酸/丝氨酸；46kDKIAA0750基因产物假定蛋白质FLJ10305CasL互作分子由单克隆抗体MRC OX-2鉴定的抗原含黄素单氧化酶4SA高血压相关同系物(大鼠)蛋白酶体(前体；macropain)亚基；β型；10假定蛋白质FLJ20514SRY(性别决定区Y)盒8HBS1样(酿酒酵母)葡糖苷酶；β；酸性(包括葡糖神经酰胺酶)磷酸二酯酶4D互作蛋白质(myomegalin)NIMA(从未处于有丝分裂基因a)相关激酶63引发修复核酸外切酶2   173.5669307.7657412.29272.21222175.384214.435580.19669264.295239.1769276.5554337.3229136.5038371.6792137.0471266.8369220.3804108.6672240.4538183.3739325.1642192.4074186.2788408.3043287.569202.5886230.8266295.5318168.0201288.5578205.6083   18934931591.321617315523827226021594309205179304172314302166276151513146268312389154208225   277.5737277.6076277.6603277.8103277.9804278.2085278.4321278.8016278.9368279.1408279.5646279.6415279.7092279.921280.5497280.5881280.9738281.002281.185281.3505281.6555281.9205281.9429281.9498281.9705282.4288282.6453282.6456283.1715283.2504   213.4547311.4328334.8518147.0989223.0558221.7567171.2074260.4802263.2799272.0232277.1331170.0401320.2206207.2587241.9692268.4079187.2889278.4551255.4932257.5072249.9252206.4709400.975238.3826251.002274.9973322.2918201.6823259.9871237.9086   6.77E-01-1.49E-01-5.70E-011.94E+006.64E-013.76E-011.80E+007.71E-022.22E-011.34E-02-2.71E-011.03E+00-4.10E-011.03E+007.23E-023.48E-011.37E+002.25E-016.17E-01-2.09E-015.50E-015.98E-01-5.34E-01-2.85E-024.77E-012.91E-01-6.43E-027.50E-01-2.72E-024.62E-01   1.25E-011.81E-01-3.90E-013.38E-012.99E-01-3.13E-019.51E-01-1.49E-011.84E-01-8.70E-02-6.53E-01-5.39E-01-2.65E-015.80E-01-5.80E-014.65E-016.64E-013.85E-017.19E-01-9.70E-015.19E-01-3.01E-013.28E-01-9.82E-014.06E-014.34E-013.95E-01-1.22E-01-4.71E-011.29E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q93065O43837Q9H9L3Q13740Q12888P78318P48436P18065Q9ULW6O95154O95169Q99982Q99470P16104Q9UG25Q13158Q9NW32O95153Q9BQ73Q15426Q92858Q16849P11279Q96II1P78504O75937   I15cd6B12ab7L06gh7A18ab2L09cd2J13ab6K24cd1B19ef1F22cd8N03cd7P14ab8C24ef4F14cd2N19ab5B04ef8C21cd4D10gh2M05cd5H06gh7C02ef7L12ab2P15ab8D07ab7I16gh7O20ab2G06ef3   MHC I类区中的PERB11家族成员异柠檬酸脱氢酶3(NAD+)β假定蛋白质FLJ12671活化的白细胞粘附分子肿瘤蛋白p53结合蛋白质；1免疫球蛋白(CD79A)结合蛋白质1SRY(性别决定区Y)-盒9(躯干发育异常；常染色体性逆转)胰岛素样生长因子结合蛋白质2(36kD)核小体装配蛋白质1样2醛-酮还原酶家族7；成员A3(黄曲霉毒素乙醛还原酶)NADH脱氢酶(泛醌)1β子复合物；8(19kD；ASHI)XIAP相关因子1基质细胞源性因子2H2A组蛋白家族；成员X含SOCS盒WD蛋白质SWiP-1通过死亡结构域相关的Fas(TNFRSF6)假定蛋白质FLJ10346外周苯并二氮_类受体相关蛋白质1假定蛋白质FKSG28蛋白酪氨酸磷酸酶；受体型；Hatonal同系物1(果蝇)蛋白酪氨酸磷酸酶；受体型；N溶酶体相关膜蛋白质1假定蛋白质MGC14961jagged 1(Alagille综合征)DnaJ(Hsp40)同系物；亚家族C；成员8   295.7132348.9961209.5906231.4555132.9276423.8715345.2087286.6516223.0694299.9079374.262463.10609230.3684234.8351213.293263.0157235.0532155.1824212.0736296.9619611.3779145.9896369.9925103.7251255.0945294.9992   45729827925322351219728314829819911631619539828138623129744127855.631080.7347264   283.4269283.6422283.6912283.7582283.8572283.9511284.0786284.2331284.717284.8919285.0096285.0252285.1394285.2056285.5392285.9553286.3524287.1271287.201287.2583287.2641287.3262287.3935287.4071287.4633287.503   345.3524310.0846257.4051256.0277213.3434406.4772275.3736284.4952218.587294.419286.0758154.8111277.1416238.3532298.9147276.784302.6214224.5106265.3817341.7927392.3029162.9842322.5735157.2667296.4108282.0586   -6.12E-02-2.99E-014.37E-012.94E-011.09E+00-5.78E-01-2.81E-01-1.22E-023.52E-01-7.41E-02-3.93E-012.18E+003.08E-012.80E-014.21E-011.21E-012.85E-018.88E-014.37E-01-4.79E-02-1.09E+009.77E-01-3.64E-011.47E+001.72E-01-3.71E-02   6.28E-01-2.30E-014.12E-011.28E-017.48E-012.71E-01-8.10E-01-2.05E-02-5.92E-01-7.00E-03-9.12E-018.82E-014.56E-01-2.68E-019.00E-019.74E-027.17E-015.75E-014.85E-015.71E-01-1.14E+00-1.39E+00-2.54E-01-3.63E-014.43E-01-1.62E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O60575Q9NYP7O95436O95324Q9UQF6P13010Q9UJZ1P50281P15927O75496Q9P1E3P40189Q9Y259O00633Q13432Q9Y677Q9BW24Q9NSD9Q9NWQ0Q9NWT6Q9UPN3Q96HW0Q14257Q9NRJ5P23280Q14677   O16ef4K05gh5H01cd6B15ab2B08ef3K12ef6P03cd8I18ab7B08cd1B02ef1C23gh4B14ab6H03ab4C12ef5H13cd5E03ef2D03ef8B12cd5C16gh3C02gh3J12ef7A06gh7F18ab8J05gh4P02ab3I02gh1   丝氨酸蛋白酶抑制剂；Kazal 4型酵母长链多不饱和脂肪酸延伸酶2同系物溶质载体家族34(磷酸钠)；成员2ATP结合盒；亚家族F(GCN20)；成员2核糖体蛋白质L36中国仓鼠细胞中X-射线修复互补缺陷修复5(双链断裂重接；Ku自身抗原；80kD)stomatin(EPB72)样2基质金属蛋白酶14(插入膜的)复制蛋白质A2(32kD)geminin早老素相关偏菱形样蛋白质白细胞介素6信号转导蛋白(gp130；制瘤素M受体)胆碱激酶样磷酸酶及张力蛋白同系物(在多种晚期癌中突变)unc-119同系物(线虫)COP9组成型光形态形成同系物亚基4(拟南芥)KIAA0676蛋白质苯丙氨酰-tRNA合成酶β亚基假定蛋白质FLJ20695缺氧可诱导因子1；α亚基抑制剂微管-肌动蛋白交联因子1锌指蛋白38(KOX 25)reticulocalbin 2；EF手钙结合结构域多聚(A)聚合酶β(睾丸特异性)碳酸酐酶VIKIAA0171基因产物   142.2326299.2029238.6021267.704519.2003174.6996490.6115126.7204100.0172466.4376232.5496330.8834328.1801199.7323127.1818186.9367170.3265226.6641497.4612521.7793578.3578126.7599237.969379.2857137.6155330.738   152187425275425256272196194454263315375189268204240219656276563355217276102204   287.9288.1627288.3247288.4558288.5855288.9405289.2003289.8803290.3306290.7216291.2445291.3287291.3288291.6118291.793291.9539292.9836293.111293.1504293.7543294.1533294.3016295.1469295.7341296.1358296.1674   194.1988257.9759317.3784277.0901410.9115239.8403350.5499204.0657194.7022403.7854262.3787312.5572331.557226.7943229.0999227.7917234.5628246.1288482.328363.8746478.6344258.7634249.8842316.91178.6789277.0019   1.02E+00-5.42E-022.73E-011.08E-01-8.47E-017.26E-01-7.63E-011.19E+001.54E+00-6.82E-013.25E-01-1.84E-01-1.72E-015.46E-011.20E+006.43E-017.83E-013.71E-01-7.63E-01-8.29E-01-9.75E-011.22E+003.11E-01-3.59E-011.11E+00-1.59E-01   1.00E-01-6.81E-018.34E-013.94E-02-2.89E-015.51E-01-8.52E-016.26E-019.54E-01-3.84E-021.79E-01-6.89E-021.93E-01-7.94E-021.08E+001.29E-014.97E-01-5.22E-024.00E-01-9.18E-01-3.78E-021.49E+00-1.36E-01-4.60E-01-4.28E-01-6.96E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y394Q9UKX5Q92539Q9NW01Q9NUW5Q9BYC4P02545O60585P23458Q9BY13Q9UBC2O76022P33993Q92963Q9HAF1Q9NZ36Q9BQQ3O95214Q9Y294O95810P30670P51946Q15290Q9NX11Q9P0S3P04554O15243O43717O95876Q9H8D5Q9Y3B6Q9P0S7   H17ef2L18cd7G02gh1G10gh3N21gh3C13gh8F01ab7A17cd6L12ef5O06gh8C05gh5A14cd7K04ef6F02cd2P09gh5P02gh4C09gh8P09ef3A21ef8O01cd4L21ab4O14ef5G18cd1A03gh3A23ef2H11ab8O05ef4G03cd7J10ef1N17gh5D24ef1E13ef2  CGI-86蛋白质整联蛋白；α11lipin 2假定蛋白质FLJ10402假定蛋白质FLJ11099线粒体核糖体蛋白质S5核纤层蛋白A/C丝氨酸/精氨酸重复基质1Janus激酶1(一种蛋白质酪氨酸激酶)hook3蛋白质表皮生长因子受体底物EPS15RE1B-55kDa相关蛋白质5MCM7微型染色体维持不足7(酿酒酵母)Ric样；在许多组织中表达(果蝇)假定蛋白质FLJ11730非特征性下丘脑蛋白质HT011高尔基磷蛋白5瘦素受体重叠转录物样1DKFZP547E2110蛋白质血清去除反应(磷脂酰丝氨酸结合蛋白质)鸟嘌呤核苷酸结合蛋白(G蛋白)；γ5细胞周期蛋白H成视网膜细胞瘤结合蛋白质6假定蛋白质FLJ20498假定蛋白质LOC51240鱼精蛋白2瘦素受体基因相关蛋白质肿瘤差异表达1假定蛋白质LOC51057肿瘤内皮细胞标志6CGI-112蛋白质假定蛋白质LOC51238   471.036899.18133260.7493165.6121228.3252478.9122707.7874318.399385.7348435.0319171.9695256.9682239.0601447.2008270.4702505.7323208.3671292.4076166.5906279.903470.8713180.4218298.4739165.3845187.2653393.1528329.3033284.4848172.7128247.105493.6755143.0704   358126235135247408294331441471271243165499414333343419243272466244346190229362391364226190288139   296.7589297.0397297.1151297.1276297.5163297.754297.9921298.2057298.2124298.2969298.6179298.7615298.875299.9377300.0397300.1219300.1696300.357301.1573301.2133301.8899301.9337302.0906302.1175302.318302.3989302.5417302.9444302.9853303.4837303.7855303.896   375.1673173.978264.3623199.1936257.4882394.9285433.306315.9302375.1408401.4116247.3586266.0871234.4011415.4004328.0993379.485283.9342337.2896237.0749284.3868412.8188242.2819315.4543219.2418239.5316352.4183340.9139317.004233.8891246.7925361.6747195.3392   -6.67E-011.58E+001.88E-018.43E-013.82E-01-6.86E-01-1.25E+00-9.45E-02-3.71E-01-5.44E-017.96E-012.17E-013.22E-01-5.76E-011.50E-01-7.53E-015.27E-013.87E-028.54E-011.06E-01-6.41E-017.43E-011.74E-028.69E-016.91E-01-3.79E-01-1.22E-019.07E-028.11E-012.96E-01-7.01E-011.09E+00   -3.97E-013.42E-01-1.49E-01-2.97E-011.11E-01-2.31E-01-1.27E+005.68E-021.95E-011.14E-016.59E-01-8.34E-02-5.33E-011.58E-016.13E-01-6.05E-017.20E-015.19E-015.47E-01-4.11E-02-1.59E-024.38E-012.12E-012.02E-012.90E-01-1.20E-012.47E-013.54E-013.88E-01-3.81E-01-7.80E-01-4.11E-02   11111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O60630O95285Q08945O43583O95149Q9HAS8Q9BQ39O15304Q15394Q9NZA3P26022Q00536Q9UMW5O95353O95808Q9BXJ8P36776Q9BUR9Q9Y3R1Q92997O14682Q9Y255Q16664P31943P49848Q04984P20719Q9H5Y0P19021Q92544Q12907   D22ab4O07gh1G17cd2D08cd3D04cd5N10gh4A23gh6C06ef6I08gh1N09ef1P23ab8L24ef5E19ef2J17cd6B03ef2O17gh8A06cd5M19gh6F23cd6D03ef7N17cd3I08cd8O17ef4O04ab7J09cd2P19ab6N08ef4D21gh7G15ab8B13gh1G07cd7   deltex同系物1(果蝇)巨噬细胞成红细胞粘附蛋白结构特异性识别蛋白质1密度调节蛋白质RNA；U转运蛋白1elaC同系物2(大肠杆菌)核仁蛋白质GU2CD27结合(Siva)蛋白质碱性亮氨酸拉链蛋白质BZAP45CDA14pentaxin相关基因；由IL-1β快速诱导PCTAIRE蛋白激酶1脑细胞粘附分子Cdc42效应物蛋白质3砷酸盐抗性蛋白质ARS2由肿瘤坏死因子α诱导的跨膜蛋白质蛋白酶；丝氨酸；15假定蛋白质MGC4614Rab接纳体1(异戊烯化)dishevelled；dsh同系物3(果蝇)外胚层神经皮质(具有BTB样结构域)px19样蛋白质蛋白质A″″不均一核内核糖核蛋白H1(H)TAF6 RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；80kD热休克10kD蛋白质1(伴侣蛋白10)同源异形盒A5假定蛋白质FLJ22795肽酰甘氨酸α酰胺化单加氧酶KIAA0255基因产物染色体5开放阅读框8   310.6617332.2343335.05203.0088186.979243.3076234.335388.75727347.7168235.195597.61703290.191452.2835395.65314187.799411.8484390.4608250.3191158.9446240.0941326.0664533.9688354.4762690.0051151.1422338.1568271.4135325.1674219.5791270.8313313.0938   22141322925325433116015338431261.3359234208225646365338207305189455286250133327326305273307222   303.9702304.0714304.6617304.7034304.889304.8937305.2734305.4708305.6252305.7623305.8598306.0473306.6326306.7186307.4311308.2116308.5755308.7431308.7948309.2314309.539309.7497310.2736310.5901310.9274311.1011311.2742311.3753311.913312.0297312.5092   278.4627349.7511289.639253.5145248.5641293.0254233.2592182.3257345.6465284.2776154.9189318.5577197.6582203.4709240.0311455.5065354.6324299.1204224.7776284.6254274.7193432.9739316.9703416.9005198.2917325.4422302.8287313.8457268.0943296.5662282.474   -3.14E-02-1.28E-01-1.37E-015.86E-017.05E-013.26E-013.82E-011.78E+00-1.86E-013.79E-011.65E+007.68E-022.55E+001.68E+007.11E-01-4.18E-01-3.40E-013.03E-019.58E-013.65E-01-7.50E-02-7.86E-01-1.92E-01-1.15E+001.04E+00-1.20E-011.98E-01-6.25E-025.06E-012.04E-01-2.70E-03   -4.93E-013.14E-01-5.48E-013.17E-014.41E-014.44E-01-5.49E-017.83E-011.42E-014.07E-01-6.72E-013.09E-012.16E+001.12E+002.60E-016.50E-01-9.78E-024.35E-013.78E-013.43E-01-7.90E-01-2.30E-01-3.09E-01-1.46E+00-1.87E-01-4.81E-022.63E-01-9.24E-023.13E-011.80E-01-4.97E-01   1111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9BW91P53365P35869Q13145O14747Q9GZT5P08174Q9H689Q9P0T7Q9H2V7Q9NWT0Q9Y6X2Q9P1P1P23919P37140Q9NW54Q9UMS0P14207Q9UHC7O75844P16587Q9NVY2Q9Y3I1Q9H320P49903O00506O00273Q08170   C03gh6M23cd8O17ab2I19cd8A18ef6H03gh7M19ef1K01gh4K05ef2I12gh8D23gh2E22cd6F10ef8H04cd7D09ab8B22gh2C05ef4E23ef1L05ef4K23cd6P18gh8P19ab2F18gh2J09ef4P21cd8J11ef4B05cd6F14ab5H11cd2  nudix(二磷酸核苷连接部分X)型基序9RAC1配偶体(arfaptin 2)芳香烃受体推断的跨膜蛋白质死亡相关蛋白质6无翼型MMTV整合位点家族；成员10A补体衰变加速因子(CD55；Cromer血型系统)假定蛋白质RG083M05.2假定蛋白质LOC51235spinster样蛋白质假定蛋白质FLJ20625活化的STAT3的蛋白质抑制剂克隆FLB1727(LOC51215)脱氧胸苷酸激酶(胸苷酸激酶)蛋白质磷酸酶1；催化亚基；β同工型大鼠nadrin同系物HIRA互作蛋白质5叶酸受体2(胎儿)makorin；环指蛋白；1锌金属蛋白酶(STE24同系物；酵母)LIM同源异形盒蛋白质4ADP核糖基化因子3假定蛋白质FLJ10439仅有F-盒的蛋白质7可变电荷；X染色体硒供体蛋白质丝氨酸/苏氨酸激酶25(STE20同系物；酵母)DNA片段化因子；45kD；α多肽剪接因子；富含精氨酸/丝氨酸4   346.395293.2566249.5731490.8698348.2382362.0025705.5781241.9641266.1575275.9977420.628149.0425419.9659123.4582355.0781432.3799504.0153235.5291243.752338.22187.11814444.3724420.4716368.7457147.0814329.031273.696328.993231.1994   31434941760845032745729132439448823733084.150367038215424317484.8348399422348446275401193   312.5575312.9335313.1153313.616313.7398313.9764314.0939314.1855314.3982314.4425314.6523315.009315.0092315.562315.7751315.8314315.8386316.0649316.3297316.3789316.6454317.1873317.2936317.6515318.4769318.9322319.3179319.634319.7733   324.483318.382326.5306470.7589370.593334.369492.3204282.3328301.4061328.1261407.636233.7882355.1102174.3854391.3748472.8474400.6081235.1893267.5313276.2357162.8523369.9292378.7795369.3121271.2531364.5082289.4017350.0198247.9554   -1.48E-019.37E-023.27E-01-6.46E-01-1.51E-01-2.05E-01-1.17E+003.77E-012.40E-011.88E-01-4.19E-011.08E+00-4.15E-011.35E+00-1.69E-01-4.53E-01-6.74E-014.24E-013.76E-01-9.63E-021.86E+00-4.86E-01-4.06E-01-2.15E-011.11E+00-4.50E-022.22E-01-4.16E-024.68E-01   -1.39E-012.51E-017.40E-013.08E-013.69E-01-1.46E-01-6.26E-012.65E-012.82E-015.13E-012.13E-016.71E-01-3.46E-01-5.53E-015.03E-016.33E-01-4.00E-01-6.13E-01-7.36E-03-9.58E-01-3.90E-02-3.52E-01-7.72E-021.93E-011.24E+004.37E-017.86E-032.87E-01-2.61E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y3B8Q9P0N0Q9BRI3Q9Y319Q16514P13489Q99987P56181P51148Q9HD34Q9HAN2P08107O60499Q9HBL3Q9BSJ8O60838Q9BTM6Q9H4L0P50402Q9NZP7P49116P11234P15408Q9P1Q8P39060Q9Y2N3P02749Q9P189O43822Q9UNZ2   N15ef8E11ef2D11gh8D19ef2M17gh1D13ef7P08ef5H21ef1N18ab8E12gh4F02gh6K13ef5N18cd3M19gh4D22gh6G09gh7M11gh8K06gh5I14ab3G05ef3G22cd2D14ab8D21ab5N05cd8P16ef6N05gh1M22ab2L20gh3B19ab4N15ef2   小片段核酸酶线粒体核糖体蛋白质L30类似于Zink转运蛋白2的假定蛋白质MGC11303CGI-30蛋白质TAF12 RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；20kD核糖核酸酶/血管生成素抑制剂牛痘相关激酶2NADH脱氢酶(泛醌)黄素蛋白3(10kD)RAB5C；成员RAS癌基因家族CGI-203蛋白质pumilio同系物2(果蝇)热休克70kD蛋白质1A突触融合蛋白10N端激酶样KIAA0747蛋白质肌动蛋白突变的SAC2抑制子2样(酵母)假定蛋白质MGC3195亮氨酸拉链蛋白质FKSG14emenn(埃-德二氏肌营养不良)钙结合蛋白质Cab45前体核受体亚家族2；C组；成员2v-ral猿猴白血病病毒癌基因同系物B(ras相关；GTP结合蛋白质)FOS样抗原2RAB3A互作蛋白质(rabin3)样1胶原；XVIII型；α1KIAA0618基因产物载脂蛋白H(β2糖蛋白I)假定蛋白质PRO1855染色体21开放阅读框2大鼠p47的可能直向同源物   120.8094377.6692373.5695107.1253116.3618224.1663205.9202435.0715329.7976257.866291.9641535.4871189.7411165.2938549.1645216.0571371.941247.34403321.3743336.1107295.9342565.699265.6989357.8493151.6584378.8717408.7454392.3328249.9987413.5167   28239139112330423219431935824932638230422457525433470.6304239224444437253212252226358297519   320.0578320.1382320.4318320.4576320.8611321.0895321.2364321.3696321.5906322.345322.4096322.6223322.7738323.2472323.5208324.4643324.5103324.6661324.6751324.6956325.1253325.5924325.8448326.2784326.8288326.8347327.1228327.1908327.8679327.9429   240.8904362.9626361.6895183.4471246.9777259.1076240.3908358.4382336.6203276.3612313.4126413.3803272.2579237.4707482.4222264.8237343.6429147.5387316.6654299.844281.6482444.9874342.8236312.2142230.0488319.0933320.758359.0228291.7148420.0654   1.41E+00-2.38E-01-2.21E-011.58E+001.46E+005.18E-016.42E-01-4.37E-01-3.64E-023.22E-011.43E-01-7.31E-017.66E-019.68E-01-7.63E-015.87E-01-1.97E-012.78E+001.47E-02-4.98E-021.36E-01-7.97E-012.94E-01-1.33E-011.11E+00-2.13E-01-3.21E-01-2.62E-013.91E-01-3.35E-01   1.22E+005.03E-026.60E-021.97E-011.38E+005.00E-02-8.59E-02-4.48E-011.20E-01-5.12E-021.58E-01-4.87E-016.81E-014.38E-016.53E-022.33E-01-1.53E-015.77E-01-8.04E-02-4.94E-01-4.03E-01-3.51E-017.18E-01-5.03E-014.81E-01-5.91E-01-8.52E-01-1.34E-012.50E-013.27E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y4G5Q13310P45974P55317O43364P55345P48230Q9BUY3O00115O43318O95572P35080Q9NW29Q9NZE9Q9BYV2Q9UJX4O00302Q92886O14929Q9NVK7Q9UBN0O43611O94777Q14669Q9NUR0Q16822Q9Y640P48595P26639   B22cd8C13cd4O14cd3A04ab7H06cd8H15ab6O22cd2C21gh5B01ef6M11cd2B08gh1K12ab8E24gh3O07ef2QE05gh8F02ef2B19cd6K23cd1P07cd3M18gh3P09ef4E14cd3G23cd4K05gh1B20gh3L08ab8A14cd8C01cd1M15cd2  动力蛋白；细胞质部分；重链多肽1多聚(A)结合蛋白质；细胞质部分4(可诱导形式)泛素特异性蛋白酶5(异构肽T)肝细胞核因子3；α同源异形盒A2HMT1 hnRNP甲基转移酶样1(酿酒酵母)跨膜4超家族成员4分选连接蛋白6脱氧核糖核酸酶II；溶酶体促分裂原活化蛋白激酶激酶激酶7mitofusin 2抑制蛋白2假定蛋白质FLJ10350BRAF35/HDAC2复合物(80kDa)环指蛋白30分裂后期促进复合物亚基5钙平衡内质网蛋白质neurogenin 1组蛋白乙酰转移酶1染色体19开放阅读框5富含脯氨酸3细胞质连接物2长萜基磷酸甘露糖基转移酶多肽2；调节亚基甲状腺激素受体互作子12假定蛋白质FLJ11196烯醇丙酮酸磷酸羧激酶2(线粒体)基质细胞源性因子受体1丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade B(卵清蛋白)；成员10苏氨酰-tRNA合成酶   376.6624316.8746268.1073273.7527511.053364.8758565.1635166.5144275.2503186.7739252.7846111.4363219.5611219.3916500.2246237.1218327.1489290.2357344.9153281.2043309.9093180.9108294.1356486.982963.09205262.4601215.234862.04001355.1309   42633831630646830741729737224727785.9173348338269382283130287344220244397107156220410422   327.9518328.1257328.8257328.8562329.1292329.5023330.825330.8949331.0554331.1308331.4516332.2299332.8499332.8813333.9675334.5884334.7371335.1054335.4301335.4383335.4526336.1459336.7183337.0199337.0769337.1655337.2906337.3872337.8401   376.7971327.507304.4284302.8162435.9554333.8774437.5376264.7192326.0947254.8269287.175176.518241.9521299.9861390.6938280.1684347.7981302.7027270.1111301.1995329.7234245.5832291.5641406.8782168.9127251.8272257.3848269.7194371.5003   -2.00E-015.03E-022.95E-012.65E-01-6.35E-01-1.47E-01-7.73E-019.91E-012.66E-018.26E-013.91E-011.58E+006.00E-016.01E-01-5.83E-014.97E-013.31E-022.07E-01-4.02E-022.54E-011.14E-018.94E-011.95E-01-5.31E-012.42E+003.61E-016.48E-012.44E+00-7.20E-02   1.77E-019.11E-022.39E-011.60E-01-1.28E-01-2.48E-01-4.40E-018.34E-014.34E-014.01E-011.33E-01-3.76E-01-3.40E-016.64E-01-5.66E-011.81E-012.22E-01-3.76E-02-1.41E+002.92E-021.50E-012.80E-01-2.71E-01-2.96E-017.56E-01-7.52E-012.92E-022.72E+002.47E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P29597O60671Q9NW97Q9P027O95772Q9NR28P11413Q99567Q9BZR9O43632Q9Y305P17096P28677Q9UBX5Q9Y304O15379Q02790Q9H240O76095Q9Y5Q8Q9NNW5P01121Q9H0V7O60664P56554O00330O60784Q9NQZ0P52790P52815   O03cd3B02ab8P17gh2O23ef8E20gh8N13gh4F15ab3A04ab8F22gh7L22cd6I05cd8L14ef6E10cd3K04cd6E12ef2L16ef6H16ab5K12ef5P22cd6P07cd7H06ef8C09ef6K18gh8P02cd5O15cd3O06cd3N17cd5H03ef4A04ab5B10cd1   酪氨酸激酶2RAD1同系物(裂变酵母)假定蛋白质FLJ10199HSPC133蛋白质假定蛋白质MGC3251半胱天冬酶的第二个线粒体源性活化子葡萄糖-6-磷酸脱氢酶核孔蛋白88kD环指蛋白27γ微管蛋白复合物蛋白质2线粒体脂酰辅酶A硫酯酶高迁移率组(非组蛋白染色体)蛋白同工型I和Y视锥蛋白样1fibulin 5卵巢癌过表达1组蛋白脱乙酰基酶3FK506结合蛋白质4(59kD)Notch同系物2(果蝇)跳跃易位断点普通转录因子IIIC；多肽5(63kD)WD重复结构域6ras同系物基因家族；成员B假定蛋白质DKFZp564O0523负荷选择蛋白质(甘露糖6磷酸受体结合蛋白质)泛素缀合酶E2G 2(UBC7同系物；酵母)丙酮酸脱氢酶复合物；含lipoyl组分X；E3结合蛋白质myb1的靶标(鸡)CMP-N-乙酰神经氨酸合酶己糖激酶3(白细胞)线粒体核糖体蛋白质L12   209.3427188.2716262.3124616.0461195.9084271.4457258.0938464.4826206.7918328.0052447.9229393.4158235.28379.52593326.0044198.0005323.5993270.5904252.8696545.6403254.1607241.7544568.248520.0919374.4383345.9372364.3098788.5176260.6034234.3191   258104536363227543135320398322475266241108238380240566227324369304304232417430317339430277   338.1471339.1461339.3086339.3102339.3844339.8107340.0217340.5878340.7239341.4805341.5085341.5301341.6123341.7638341.8947342.3529343.4254343.4339343.482343.9958344.0253344.0732344.2985344.5523345.0269345.2213345.2431345.3498345.4621345.7776   268.5377210.3983379.0815439.5495254.0574384.7351244.4906375.0149315.1764330.4468421.5064333.78272.797176.4964301.8585306.8418302.2597393.3189274.4316404.6602322.3381296.4811405.6684365.5782378.959373.6892342.086491.0715345.2169285.7775   6.92E-018.49E-013.71E-01-8.60E-017.93E-013.24E-013.98E-01-4.48E-017.20E-015.81E-02-3.91E-01-2.04E-015.38E-012.10E+006.87E-027.90E-018.58E-023.44E-014.42E-01-6.66E-014.37E-015.09E-01-7.23E-01-5.94E-01-1.18E-01-2.99E-03-7.76E-02-1.19E+004.07E-015.61E-01   3.02E-01-8.59E-011.03E+00-7.62E-012.12E-011.00E+00-9.31E-01-5.38E-019.45E-01-2.73E-028.49E-02-5.62E-013.76E-024.44E-01-4.56E-019.41E-01-4.33E-011.06E+00-1.56E-01-7.50E-015.37E-013.29E-01-9.00E-01-1.16E+001.57E-013.14E-01-2.02E-01-1.22E+007.21E-012.43E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O14983P04259P16455Q9Y5L9P41214Q9H6U4Q15393P55055P51805O75815Q9Y2Y9Q99633P05155Q9UN50Q14011O75807Q14457Q02818O15235Q9Y3E0Q9NQZ5Q9UHW4P82914P25787P26447Q9Y605Q14776   O10ef1D01ab7M04ef6N04cd6A16gh1P13gh5L10ef7C04gh1M03ef4G23ab3F19ef2D04cd3C08ab3O16cd7E11ab4M02ef3K19ab3J06ef6L10gh1A02ef2H19gh4D24ef8P04gh7L11ef7D02cd1P02gh8K14cd4   ATP酶；Ca++转运；心肌；快速颤搐1角蛋白6BO-6-甲基鸟嘌呤-DNA甲基转移酶Snf2相关CBP激活蛋白连接素假定蛋白质FLJ21865剪接因子3b；亚基3；130kD核受体亚家族1；H组；成员2SEX基因乳腺癌抗雌激素抗性3Kruppel样因子13前mRNA加工因子18丝氨酸(或半胱氨酸)蛋白酶抑制剂；clade G(C1抑制剂)；成员1；(血管性水肿；遗传性)LL复合物的EAP30亚基冷诱导的RNA结合蛋白质蛋白磷酸酶1；调节(抑制剂)亚基15Abeclin 1(卷曲螺旋；肌球蛋白样BCL2互作蛋白质)nucleobindin 1线粒体核糖体蛋白质S12CGI-141蛋白质含START结构域7蛋白质x 0001线粒体核糖体蛋白质S15蛋白酶体(前体；macropain)亚基；α型；2S100钙结合蛋白A4(钙蛋白；calvasculin；metastasin；小鼠胎盘同系物)T细胞活化蛋白质亮氨酸拉链样转录调节子；1   167.4066534.1837299.0887285.2875237.0742419.2747242.1115325.6291303.0664249.1903241.1753405.046303.3386321.9045292.5107371.7509368.4142330.8747355.1234152.8668277.2941266.9848444.1517432.9379198.7401411.1148202.0365   223405307187307175239368383293366348334326412652678213467320280291417526273356273   346.1734347.6543348.0545348.0925348.5538348.8375349.6571349.8393350.6414350.9571351.0501351.3478351.5074351.5535351.6685352.5048352.9542353.1168353.2438353.6986353.7264353.7644354.4965355.1116355.1396355.1531355.4522   245.4613428.9832318.0812273.2945297.4677314.4039277.0735347.7942345.4093297.768319.2905368.1886329.7432333.1657352.0144458.6852466.4393298.8382391.6738275.4907303.5369303.9535405.0567437.9448275.5734373.9359276.788   1.05E+00-6.20E-012.19E-012.87E-015.56E-01-2.65E-015.30E-011.03E-012.10E-014.94E-015.42E-01-2.05E-012.13E-011.27E-012.66E-01-7.67E-02-6.18E-029.39E-02-7.66E-031.21E+003.51E-014.06E-01-3.25E-01-2.86E-018.38E-01-2.11E-018.15E-01   4.12E-01-3.99E-013.81E-02-6.13E-013.72E-01-1.26E+00-1.59E-021.76E-013.36E-012.34E-016.00E-01-2.18E-011.41E-011.84E-024.94E-018.10E-018.80E-01-6.39E-013.94E-011.07E+001.19E-021.25E-01-9.27E-022.80E-014.57E-01-2.10E-014.34E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P30837P09668Q02313Q13148Q16645P57739O60568Q9HAU4P49914O60510Q9BX68P29084P09526O15471Q9UEE9Q15011Q9BWG8Q9Y397Q14596P23497Q16633Q99961Q07021Q16513Q9H070   C02ab2L03ef7J02gh6H11cd7K24ab5N02gh8F18gh1F13cd4N11gh5J01cd6E11cd8L15gh8B02ab5C05ef6P01ef4K03ab3L03ef3A13gh6A04ef2H17ab7C13cd2A24cd1J12cd1N20ab3E04cd1H10cd8   醛脱氢酶1家族；成员B1组织蛋白酶HKrueppel相关锌指蛋白TAR DNA结合蛋白质FK506结合蛋白质1B(12.6kD)蛋白磷酸酶1；调节(抑制剂)亚基14Aclaudin 2前胶原-赖氨酸；2-酮戊二酸5-加双氧酶3E3泛素连接酶SMURF25；10-次甲基四氢叶酸合成酶(5-甲酰四氢叶酸环连接酶)atrophin-1互作蛋白质1；activin受体互作蛋白质1三联组氨酸核苷酸结合蛋白质2普通转录因子IIE；多肽2(β亚基；34kD)RAP1B；成员RAS癌基因家族白细胞免疫球蛋白样受体；亚家族B(具有TM和ITIM结构域)；成员3颅面发育蛋白质1高半胱氨酸诱导性；内质网应力诱导性；泛素样结构域成员1假定蛋白质MGC2491锌指；包含DHHC结构域9膜组分；染色体17；表面标志2(卵巢癌抗原CA125)核抗原Sp100POU结构域；2类；关联因子1SH3结构域GRB2样1补体成分1；q亚成分结合蛋白质蛋白质激酶C样2接头相关蛋白质复合物2；α1亚基   631.0407460.8488402.289322.5816216.770477.52993188.162332.5306425.5948340.2344171.9425207.0703261.3572320.4156219.8277124.0304352.4459170.1162431.1743303.2476331.8296103.1231231.086471.8742546.0111353.2901   45156439135348671.123826966523826536022535526024518320349540249199.3247202561278   355.7998356.7735356.9162357.1404357.2698357.2714357.443357.5594357.6911358.0826358.342358.5328358.821359.0861359.2909359.5047359.7095360.534360.6182361.5265361.9825362.0007362.8536363.3385364.4852364.7541   479.1158460.5856383.4797344.328353.4204168.643261.2968319.8117482.7167312.027265.2168308.6409281.687344.9493279.8225242.684298.5074244.6389428.8727355.7499394.8464188.1549280.235345.9018490.5792331.9695   -8.27E-01-3.69E-01-1.73E-011.47E-017.21E-012.20E+009.26E-011.05E-01-2.51E-017.38E-021.06E+007.92E-014.57E-011.64E-017.09E-011.54E+002.94E-021.08E+00-2.58E-012.54E-011.25E-011.81E+006.51E-01-3.77E-01-5.83E-014.61E-02   -4.86E-012.92E-01-4.02E-021.31E-011.17E+00-1.24E-013.41E-01-3.04E-016.44E-01-5.17E-016.26E-017.99E-01-2.17E-011.49E-012.44E-019.79E-01-9.43E-012.57E-011.99E-014.08E-015.64E-01-5.39E-029.47E-02-1.22E+003.97E-02-3.46E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q13227P20339Q9NXX4Q92900Q9H2K4O14917Q9NZ88Q9BYC8Q15311Q9NWE9O95571P36941P49790Q99607Q9UIV1Q9Y3E4P19367Q14250Q9UL33Q15019Q13084Q9UMR2P55855Q13155P78371P08173O60478O60429O75935Q13147   A16ab5M03ef5G15gh2N17cd1I05gh3E17ef4J06gh3C15gh8C21cd7E02gh3G22ef3A09ab7F11cd5C06ab4H05cd8O13ef2D17ab3J15cd5B20ef2H03ef5H05cd6O18cd7H06cd2G20cd4H11cd6P17ab3E02cd2D16gh4O04cd7J05ab2   G蛋白通路抑制物2RAB5A；成员RAS癌基因家族假定蛋白质FLJ20005无义转录物调节子1染色体11开放阅读框24原钙粘蛋白17染色体6开放阅读框35线粒体核糖体蛋白质L32ralA结合蛋白质1假定蛋白质FLJ10074甲状腺中表达的蛋白质淋巴毒素β受体(TNFR超家族；成员3)核孔蛋白153kDE74样因子4(ets结构域转录因子)CCR4-NOT转录复合物；亚基7CGI-146蛋白质己糖激酶1enigma(LIM结构域蛋白质)未知神经前体细胞表达的；发育下调的5由细胞毒性T淋巴细胞识别的黑素瘤相关抗原DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽19(DBP5同系物；酵母)mif两个3同系物2的SMT3抑制基因(酵母)JTV1基因包含伴侣蛋白的TCP1；亚基2(β)胆碱能受体；毒蕈碱4跨膜7超家族成员1(肾中上调)假定蛋白质FLJ12886动力蛋白激活蛋白3(p22)abI互作蛋白2   557.5311404.6579155.2731328.2926198.6548250.3859199.6701257.9414295.4648455.3747398.0124403.0565264.6175267.135201.0959107.5317512.0647229.1944343.1533489.0601421.8259383.654454.9011322.6641480.5464444.2461274.7639142.8322408.9696299.098   352664246316155311362429411383507454316268465262215218636274278423444409430514438257432249   364.8449365.7139365.9622366.2931366.4866366.6879367.2681367.9727368.6028369.4489369.925370.0343370.2793371.3515371.6771371.8333371.9817371.9927372.4427372.9279373.0512373.0622373.596373.7416374.014374.4117374.61375.0573375.1224375.379   424.6909478.1731255.5867336.7297240.051309.398309.7781351.4981358.3107402.6031425.0962409.094317.116302.1703345.9619247.1535366.4437272.9152450.4535378.666357.6504393.1434424.0867368.4293428.2475444.3189362.4989258.282405.4281307.9098   -6.12E-01-1.46E-011.24E+001.58E-018.83E-015.50E-018.79E-015.13E-013.19E-01-3.02E-01-1.06E-01-1.23E-014.85E-014.75E-018.86E-011.79E+00-4.61E-016.99E-011.18E-01-3.91E-01-1.77E-01-4.04E-02-2.84E-012.12E-01-3.62E-01-2.47E-014.47E-011.39E+00-1.25E-013.28E-01   -6.65E-017.15E-016.61E-01-5.69E-02-3.58E-013.13E-018.60E-017.33E-014.76E-01-2.50E-013.50E-011.72E-012.58E-014.79E-031.21E+001.29E+00-1.25E+00-7.52E-028.90E-01-8.36E-01-6.01E-011.40E-01-3.58E-023.42E-01-1.60E-012.11E-016.73E-018.47E-017.97E-02-2.63E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NPH4Q9UJ96P17081P11166Q14820Q92935P31749Q13454P35520P53602Q9H7G3Q13123O14744Q9Y566Q9BUJ9P51790O14547Q99753Q9NQC8O43919P78345P54257Q9Y3F4P29536O75925Q9UMX5Q9UMZ9   E14gh3C13cd8C13ef6J05ef5D12ef6I06ab5E20ef6L05cd7C24ab3M01ab7C04gh6C06ab7G14cd6D16ef8A03gh7I02ab5J09cd6A05cd7H15gh4M01ef6F15cd6A03ef5G18cd7F14cd7K03cd4J23ef4N02cd7   LUC7样(酿酒酵母)钾电压门控通道；亚家族G；成员2小鼠TC10-α的可能直向同源物溶质载体家族2(促进葡萄糖转运蛋白)；成员1剪接因子1exostoses(多发性)样1v-akt小鼠胸腺瘤病毒癌基因同系物1推断的前列腺癌肿瘤抑制基因胱硫醚-β-合酶甲羟戊酸(二磷酸)脱羧酶线粒体核糖体蛋白质L24IK细胞因子；HLA II负调节物RAD1同系物(裂变酵母)SH3及多个锚蛋白重复序列结构域1Mov10；莫洛尼白血病毒10；同系物(小鼠)氯离子通道3PRP8前mRNA加工因子8同系物(酵母)顺铂抗性相关假定蛋白质LOC56912T细胞活化的接头核糖核酸酶P(38kD)huntingtin相关蛋白质1(neuroan1)uri互作蛋白质leiomodin 1(平滑肌)活化的STAT的蛋白质抑制剂；1未知功能的分泌蛋白质白细胞介素增强子结合因子3；90kD   207.38582.717293.1604351.7333382.846659.9005385.4669326.914670.85109682.0309333.6677257.7332348.0026209.2687385.0517330.2251239.0005257.1873185.2607206.6586321.791450.2874390.9437343.3731423.9992344.8668348.7866   30244841739340827630336368.1178207439410281472237256397276105530322335209606306278   376.3768376.4373376.4996376.564376.7779376.8548376.9169377.0852377.1148378.114378.1396378.1806378.4165379.5197380.308380.3105380.5886380.7894381.0416381.2059381.5687382.6029382.6142382.9438383.7943384.5676384.7729   295.4166468.9343362.2816373.8343389.2167437.6869355.1851355.5691172.0203412.6357306.3867358.3456378.8177290.0718412.4352315.7621291.9777345.0384280.7773230.823411.2575384.9948369.3734311.936471.2944345.2233337.1554   8.60E-01-6.30E-013.61E-019.84E-02-2.30E-02-8.08E-01-3.24E-022.06E-012.41E+00-8.51E-011.81E-015.53E-011.21E-018.59E-01-1.79E-022.04E-016.71E-015.66E-011.04E+008.83E-012.46E-01-2.35E-01-3.11E-021.57E-01-1.44E-011.57E-011.42E-01   5.45E-01-3.80E-015.09E-011.61E-019.19E-02-1.26E+00-3.46E-011.50E-01-5.72E-02-1.94E+00-6.86E-017.69E-012.37E-014.27E-012.94E-01-4.80E-011.01E-016.27E-015.75E-01-9.82E-017.21E-01-4.83E-01-2.25E-01-7.13E-015.15E-01-1.71E-01-3.28E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q92905Q9NSD7Q9P2W3Q9BVI7Q9Y4L1Q02363Q9Y5J8Q99501Q00613Q9H5Z1P09661P54709P13164Q9Y6E2Q9NVG2P27448O15438Q9UL48O94763Q13190Q13122O75312P37837O75762Q99969Q9UNP2   P03ef6L20ef1G01ef3N14gh5B23cd6F18ab7E06cd8E22ef1N11cd6M17ef5H16gh4P24cd1P05ef5M06ef5A23ef8B13gh3E10ef5P18cd3I04ef2A11cd4I19cd2D21ef3L01cd4D20cd2G19cd6K19ef3H15cd2   COP9组成型光形态形成同系物亚基5(拟南芥)G蛋白偶联受体SALPR；生长抑素和血管紧张素样肽受体鸟嘌呤核苷酸结合蛋白11；γ线粒体核糖体蛋白质S34氧调节蛋白质(150kD)DNA结合抑制剂2；显性负相螺旋-环-螺旋蛋白线粒体内膜易位酶10同系物(酵母)G蛋白偶联受体26生长抑制特异性2样1热休克转录因子1DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽35核内小分子核糖核蛋白多肽A′ATP酶；Na+/K+转运；β3多肽干扰素诱导的跨膜蛋白质1(9-27)HSPC028蛋白质空泡蛋白质分选35(酵母)MAP/微管亲和力调节激酶3ATP结合盒；亚家族C(CFTR/MRP)；成员3CK2互作蛋白质1；HQ0024c蛋白质RPB5介导蛋白质突触融合蛋白5AEBNA-2辅激活因子(100kD)锌指蛋白259转酰酶1具有跨膜结构域1的锚蛋白样视黄酸受体反应物(tazarotene诱导的)2溶质载体家族1(中性氨基酸转运蛋白)；成员5   257.5597734.628270.71144367.7177413.0575484.7132440.2763499.1316359.8065363.3847136.5899441.1409425.664745.13817329.8857359.0233397.7845618.0409176.5553333.6215179.6148381.3069348.7542399.2717222.8517283.5705149.1019   39227781.4520372359542450540375124115432256363557369488215533235375422326364257138   386.1452386.7193386.7442386.9198387.5372388.2552388.4554389.582389.6398389.8695389.9835390.2085391.8135392.1204392.2431392.2574392.3918392.8159393.4111393.9448393.985394.5999394.8016395.693395.7427396.0287396.5014   345.1985466.2798179.6321424.8293390.9975410.6421456.8557446.2248429.6515376.2292217.0007315.5701416.5779231.1336361.6248436.0959386.4633499.6643261.8209420.3384269.5995383.7948388.3905373.7275327.3962312.0672227.7665   5.84E-01-9.26E-012.45E+007.34E-02-9.20E-02-3.20E-01-1.81E-01-3.57E-011.15E-011.01E-011.51E+00-1.77E-01-1.20E-013.12E+002.50E-011.28E-01-1.97E-02-6.54E-011.16E+002.40E-011.13E+004.94E-021.79E-01-1.30E-028.28E-014.82E-011.41E+00   6.06E-01-1.40E+002.04E-014.99E-01-1.49E-01-4.33E-012.99E-01-1.50E-015.84E-014.71E-02-1.35E-01-1.94E+002.22E-022.50E+001.37E-016.34E-01-1.08E-01-3.40E-012.88E-016.77E-013.89E-01-2.22E-022.74E-01-2.92E-017.06E-01-1.44E-01-1.15E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P56524Q9H644Q13627Q03405Q9NPQ8Q15375P05114Q9UKU4P08195Q15545Q05397Q9Y6G1P41212O14737Q9UHB9Q96D21Q9Y4I1Q9Y5L4O75439P55010Q9BY44Q13164P53667Q9UNH6O00258Q9Y3I0Q9Y368   C23cd6C19gh6O19ab4O01ef5L18gh4A10ab5G04ab7C13ef2E21ab7J11cd2D24gh8L20ef5C21ef8O23ef5G05cd5A10ef3C20ef8J05ef1L14ef7N22cd4K22ab4G10gh8B21ef5P08ab6F05ef2K17cd4I12ef3D13cd8   组蛋白脱乙酰基酶4假定蛋白质MGC5585双特异性酪氨酸-(Y)-磷酸化调节的激酶1A纤溶酶原活化因子；尿激酶受体小鼠synembryn的可能直向同源物EphA7高迁移率组(非组蛋白染色体)蛋白14视黄醛短链脱氢酶/还原酶retSDR2溶质载体家族3(双碱性核中性氨基酸转运蛋白活化剂)；成员2TAF7RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；55kD假定蛋白质FLJ14511PTK2蛋白质酪氨酸激酶2PTD011蛋白质ets变体基因6(TEL癌基因)程序性细胞死亡5信号识别颗粒68kDRASD家族；成员2肌球蛋白VA(重链多肽12；myoxin)线粒体内膜易位酶13同系物(酵母)肽酶(线粒体加工)β真核翻译起始因子5CDA02蛋白质促分裂原活化蛋白激酶7UM结构域激酶1分选连接蛋白7富含色氨酸碱性蛋白质假定蛋白质parvin；β   328.6037140.9811498.484500.1391372.8251243.0574196.8334370.8225442.5453400.689246.3293389.8718434.6906315.7331498.729212.5357395.909371.5954291.7019512.9004427.4989453.6064209.1026359.4655479.6898339.3172458.2693114.232   303228327396443290278497345526225440483502430247486353369184296401256392396500546159   397.1317397.2624397.3922398.2456398.4083398.5414398.7327399.4413399.5678401.1308401.3816401.4713401.5119401.8428402.3091402.3276402.4304402.453404.0738404.5715405.4996405.956406.234406.5183406.7812407.1504407.2408407.3882   342.9334255.3931407.7774431.3524404.6217310.569291.2748422.4244395.768442.5426290.8781410.2909439.8467406.6035443.7457287.2236427.9499375.8247354.9111367.0789376.3076420.1404290.5304386.0829427.3762415.5431470.3717226.9908   2.73E-011.49E+00-3.27E-01-3.29E-019.57E-027.13E-011.02E+001.07E-01-1.47E-011.59E-037.04E-014.23E-02-1.15E-013.48E-01-3.10E-019.21E-012.36E-021.15E-014.70E-01-3.42E-01-7.62E-02-1.60E-019.58E-011.77E-01-2.38E-012.63E-01-1.70E-011.83E+00   -1.17E-016.93E-01-6.06E-01-3.38E-012.48E-012.55E-014.99E-014.23E-01-3.58E-013.92E-01-1.31E-011.73E-011.53E-016.70E-01-2.13E-012.16E-012.94E-01-7.23E-023.39E-01-1.48E+00-5.31E-01-1.78E-012.93E-011.26E-01-2.78E-015.60E-012.52E-014.80E-01   1111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P14866Q13885O43765O14632P31939P28331P41970Q92973P36507Q16512O43447P30040O95399Q12792Q14318O75955Q9BVY8Q16288O75380Q9BY51Q9BVK3Q9P0N3P24534P49336P34130   H13ab6K01cd3J06cd1B12ef4L10ab2P18ab8P05ef6J22ab6J10ef5F21ab8M08cd6M13ef3C19cd7M01ab3N11ab8J02cd7N10cd5B09gh7O19ef5J20ab8B15gh8E19gh6A24ef2D03ab4C01ab4P16cd2   不均一核内核糖核蛋白L微管蛋白；β多肽小的包含tetratricopeptide重复的富含谷氨酰胺同源异形结构域互作蛋白质激酶35-氨基咪唑-4-氨甲酰核糖核苷酸甲酰基转移酶/IMP环水解酶NADH脱氢酶(泛醌)Fe-S蛋白质1(75kD)(NADH-辅酶Q还原酶)ELK3；ETS结构域蛋白质(SRF辅助蛋白质2)karyopherin(importin)β2促分裂原活化蛋白激酶激酶2蛋白质激酶C样1肽基脯氨酰异构酶H(亲环蛋白H)染色体12开放阅读框8硬骨鱼紧张肽2UDP-Gal：βGalβ1；3-半乳糖基转移酶；多肽6蛋白质酪氨酸激酶9FK506结合蛋白质8(38kD)flotillin 1假定蛋白质MGC5499神经营养性酪氨酸激酶；受体；3型NADH脱氢酶(泛醌)Fe-S蛋白质6(13kD)(NADH-辅酶Q还原酶)假定蛋白质GL009假定蛋白质MGC2463假定蛋白质FLJ10597真核翻译延伸因子1β2细胞周期蛋白依赖性激酶8神经营养蛋白5(神经营养蛋白4/5)   442.5489441.2669378.9705394.449501.3028490.4347205.9453393.6551395.22456.2727179.441346.6792452.0721499.9529476.3952461.2322304.6674490.2382126.7467449.5778429.1998462.5828137.7487347.2405426.3751327.4146   274413438535386417359234437486222296366290364432310417186413354387289328281223   407.4025407.8683408.6453408.8773409.3069409.3283410.8037410.9425411.4052411.8245411.9165412.2064413.1451413.3454413.4208413.4238415.4364416.02416.4128416.4836417.3575417.7046417.999418.0152418.121418.6011   374.6383420.8456408.6939446.1081432.286438.7901325.3706346.1733414.6953451.4528271.0162351.5665410.4914401.0113418.007435.6453343.496440.9559243.0358426.4999400.0464422.5145281.424364.5026375.2575323.0643   -1.19E-01-1.14E-011.09E-015.18E-02-2.92E-01-2.61E-019.96E-016.20E-025.79E-02-1.48E-011.20E+002.50E-01-1.30E-01-2.74E-01-2.05E-01-1.58E-014.47E-01-2.37E-011.72E+00-1.10E-01-4.04E-02-1.47E-011.60E+002.68E-01-2.82E-023.54E-01   -6.92E-01-9.41E-022.10E-014.40E-01-3.76E-01-2.35E-018.03E-01-7.51E-011.46E-019.18E-023.05E-01-2.29E-01-3.04E-01-7.87E-01-3.87E-01-9.35E-022.68E-02-2.35E-015.53E-01-1.21E-01-2.80E-01-2.56E-011.07E+00-8.11E-02-6.00E-01-5.53E-01   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O75425Q15293O95376O75489P28482P20823O15250P55769O94817O75352Q16585Q9H7X7O15173Q9GZX9Q16594O00479P54760P25490Q9UJY0Q09666O15305O60492Q9UND3Q9HB15Q9Y3B4Q14107   P06gh5F16ab8D08ab2J16ab8B15ef5B09cd1I04cd4P22ab8N21ab2K08cd5I16cd1B16gh5I16cd6A16gh4M09cd2O17gh1C22ab5F06ef6B07ef3A22ef1P22ab7M09ab4G11cd6M15gh5H23ef2F05ef5   假定蛋白质AF053356CDS3reticulocalbin 1；EF手钙结合结构域ariadne同系物2(果蝇)NADH脱氢酶(泛醌)Fe-S蛋白质3(30kD)(NADH-辅酶Q还原酶)促分裂原活化蛋白激酶1转录因子1；肝细胞；LF-B1；肝细胞核因子(HNF1)；白蛋白邻近因子X脯氨酰氨肽酶(氨肽酶P)样NHP2非组蛋白染色体蛋白质2样1(酿酒酵母)APG12自体吞噬12样(酿酒酵母)甘露糖-P-多萜醇利用缺陷1sarcoglycan；β(43kD抗肌萎缩蛋白相关糖蛋白)假定蛋白质FLJ14117黄体酮受体膜组分2扭曲的原肠胚形成TAF9RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；32kD高迁移率组(非组蛋白染色体)蛋白17样3EphB4YY1转录因子推断的核苷酸结合蛋白质；雌二醇诱导AHNAK核蛋白质(桥粒联结蛋白)磷酸甘露糖变位酶27-脱氢胆固醇还原酶核孔复合物互作蛋白质钾通道；亚家族K；成员12CGI-110蛋白质D123基因产物   340.4357241.6383254.1122375.7034493.835322.4782524.8188137.3557631.6055272.444256.2113261.9578295.048184.61732171.3507265.695528.7066481.2844505.9493392.0671325.0777388.5228280.8175473.5589290.9669387.0465   339250322327452527542479402523293463244147520354413530431399480213312408331405   419.3637420.5597420.8229422.3772422.4625423.4405423.7387424.0031424.3577424.8266425.1172425.3725425.8728426.1124426.7606426.7642427.0543427.184427.3544427.3828428.3778428.5923428.5952428.9306429.1497429.9331   366.1692304.1243332.2465375.1108456.1064424.3654496.7532346.68485.9574406.7998324.9166383.5805321.6602219.3062372.6331348.9168456.4179479.4548454.8441406.041411.2528343.3316340.6147436.9131350.4808407.3091   3.01E-017.99E-017.28E-011.69E-01-2.25E-013.93E-01-3.09E-011.63E+00-5.74E-016.41E-017.31E-016.99E-015.29E-012.33E+001.32E+006.84E-01-3.08E-01-1.72E-01-2.44E-011.24E-013.98E-011.42E-016.10E-01-1.43E-015.61E-011.52E-01   -7.34E-035.01E-023.41E-01-1.99E-01-1.28E-017.09E-014.57E-021.80E+00-6.52E-019.41E-011.96E-018.23E-01-2.74E-017.99E-011.60E+004.15E-01-3.55E-011.39E-01-2.31E-012.41E-025.63E-01-8.68E-011.54E-01-2.14E-011.87E-016.52E-02   11111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P52435Q9Y262P10163P38378P48735Q9NPF5O14616Q00839O95563Q92974Q9UEE5Q9NX81Q9NXF9P98171P56192O95411P09132Q92537P49761Q9HDC4P98160Q9NQV6Q9NRX6O76084   A22cd1L11ef2L20cd2F01cd8B06ab6F02gh4K22cd4A12ab7J15ef8I03cd6M07cd5O19gh3O01gh3F13ef1I14ab7K09cd5E23cd2O24gh1G03ab4O19gh4A13ef7O22gh4J09gh4A13cd4   聚合酶(RNA)II(DNA指导的)多肽J(13.3kD)真核翻译起始因子3；亚基6互作蛋白质富含脯氨酸蛋白质BstNI亚家族4蛋白质转运蛋白质SEC61α亚基同工型1异柠檬酸脱氢酶2(NADP+)；线粒体DNA甲基转移酶1相关蛋白质1锌指蛋白样1不均一核内核糖核蛋白U(支架附着因子A)DKFZP564B167蛋白质rho/rac鸟嘌呤核苷酸交换因子(GEF)2丝氨酸/苏氨酸激酶17a(凋亡诱导)包含BTB(POZ)结构域2O-连接甘露糖β1；2-N-乙酰葡糖胺转移酶Rho GTP酶活化蛋白质4甲硫氨酸转移RNA合成酶TGFB1诱导的抗凋亡因子1信号识别颗粒19kDKIAA0247基因产物CDC样激酶3junctophilin 3硫酸类肝素蛋白多糖2(基底膜蛋白多糖)包含PR结构域10蛋白质x013连环蛋白(钙粘蛋白相关蛋白质)；α样1   527.0446591.5767521.4154635.5838600.2178451.5343194.5871416.5145390.848142.3392397.8599175.3887477.6375368.9887263.0076233.3926227.8193291.1054458.9286346.7829505.6962369.157324.5306471.1305   461311251369338382348410389124472206353231295310595232562388372514345211   429.9488430.6788431.1299431.9958432.1616432.3473432.4885432.5188432.8082433.2386433.4221433.4811434.2927435.3585435.894436.2684436.5994437.1141437.5601439.282439.9544440.5347440.8995441.7617   472.7272444.385401.2036478.7225456.8577421.964324.9789419.7665404.2972233.2947434.4129271.6819421.54345.0241331.1505326.6136419.7603319.914486.0405391.3835439.0897441.3923370.1383374.6479   -2.94E-01-4.58E-01-2.74E-01-5.57E-01-4.74E-01-6.26E-021.15E+005.44E-021.47E-011.61E+001.24E-011.31E+00-1.37E-012.39E-017.29E-019.02E-019.38E-015.86E-01-6.88E-023.41E-01-2.01E-012.55E-014.42E-01-9.29E-02   -1.93E-01-9.28E-01-1.05E+00-7.86E-01-8.28E-01-2.41E-018.38E-01-2.18E-02-5.96E-03-1.95E-012.46E-012.33E-01-4.38E-01-6.77E-011.63E-014.10E-011.38E+00-3.30E-012.91E-011.62E-01-4.44E-014.79E-018.82E-02-1.16E+00   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P23197Q99439O14656Q9NPJ3P41226Q9Y478Q12904P20264Q15428P49771P49005Q99879P49821P10644Q9Y5J4P31040Q9UHA2Q9UBF6Q9Y5S2P20809Q13526Q9NWQ9Q9Y6J0   E19cd7E10ab6O04ef6P04gh4B10ef7C24cd1P06cd8O06eF7C02cd1B11cd4G06ef6A18cd1M14gh6G20cd1H22ef5L17gh6K02cd2F04eF8C02ef3C21cd6H07ef7F21ef5H01gh2E05cd8   chromobox同系物1(HP1β同系物果蝇)calponin 2张力失常1；扭转(常染色体显性；torsinA)非特征性下丘脑蛋白质HT012泛素活化酶E1样蛋白激酶；AMP活化的；β1非催化亚基结节同系物(小鼠)可诱导小细胞因子亚家族E；成员1(内皮单核细胞活化)POU结构域；3类；转录因子3剪接因子3a；亚基2；66kDfms相关酪氨酸激酶3配基聚合酶(DNA指导的)；δ2；调节亚基(50kD)H2B组蛋白家族；成员ENADH脱氢酶(泛醌)黄素蛋白1(51kD)蛋白质激酶；cAMP依赖性；调节；I型；α(组织特异性消失基因1)5-羧化吡咯啉还原酶同工型琥珀酸脱氢酶复合物；亚基A；黄素蛋白(Fp)染色体18上滑膜肉瘤易位基因样2环指蛋白7CDC42结合蛋白质激酶β(DMPK样)白细胞介素11蛋白质(肽酰-脯氨酰顺/反异构酶)NIMA互作1假定蛋白质FLJ20671神经钙蛋白结合蛋白质1   480.8183429.1961415.3893411.0811298.6597306.0158349.4202374.6683458.6994284.0454449.6827363.5225325.9523511.5488420.8225145.6987671.3369438.6951315.6541386.9683399.048333.4194430.7122474.3964   362304533430342165252459302334417232483392518303351480400447140460577117   441.9595442.4148442.9429443.2575443.334443.5049443.7188445.5171447.8929448.6652452.1329452.6832452.8012454.6223454.8256455.1667456.2212456.469456.9368456.9709458.1544458.2237458.2293458.7489   428.3076391.978463.6417428.1718361.2685304.7576348.2928426.5346402.9521355.7289439.4747349.3417420.7323452.5721464.5909301.448492.7974458.4094390.7196430.2759332.3748417.3666488.6936350.127   -1.22E-014.38E-029.27E-021.09E-015.70E-015.35E-013.45E-012.50E-01-3.44E-026.60E-017.84E-033.16E-014.74E-01-1.70E-011.12E-011.64E+00-5.57E-015.73E-025.34E-012.40E-011.99E-014.59E-018.93E-02-4.84E-02   -4.09E-01-4.96E-013.59E-016.55E-021.95E-01-8.93E-01-4.73E-012.94E-01-6.02E-012.36E-01-1.10E-01-6.49E-015.69E-01-3.86E-013.00E-011.06E+00-9.36E-011.30E-013.40E-012.08E-01-1.51E+004.66E-014.22E-01-2.02E+00   111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9Y4Z6Q01433O43181Q9NWT5O75431P09543Q9BTE1P16152O15121O60909O75223Q9BQA1O43427Q9BWG6Q9Y6R2Q9HBK7P52758P47897Q9BWQ6P35325Q9HA68P49366Q9UKZ7P01730P20674Q12828Q9Y6A4O60888O75716P30711Q15008   B13cd7G02ab2M07ab8D15gh2P19cd6A18gh7B05gh8H14ab5D06cd3E09ab3C11gh6K03gh6F20cd4A15gh6M04cd6M07gh4E04ef7E19cd1P20gh5H22cd2O23gh5P16ab5J18ef1K15ef5L06cd4H02ef6J18ef3B09ef2F08cd3E18eF7L03gh1   空泡蛋白质分选45A(酵母)腺苷一磷酸脱氨酶2(同工型L)NADH脱氢酶(泛醌)Fe-S蛋白质4(18kD)(NADH-辅酶Q还原酶)假定蛋白质FLJ20618metaxin 22′；3′-环核苷酸3′磷酸二酯酶动力蛋白激活蛋白4碳酰还原酶1退化精母细胞同系物；脂质去饱和酶(果蝇)UDP-Gal：βGlcNAcβ1；4-半乳糖基转移酶；多肽2假定蛋白质MGC3077MEP50蛋白质成纤维细胞生长因子(酸性)细胞内结合蛋白质假定蛋白质MGC3180染色体4开放阅读框1NPD007蛋白质翻译抑制剂蛋白质p14.5谷氨酰胺酰-tRNA合成酶假定蛋白质MGC3262富含脯氨酸的小蛋白质2B假定蛋白质FLJ12154deoxyhypusine合酶结肠癌相关蛋白质CD4抗原(p55)细胞色素c氧化酶亚基Vafar上游元件(FUSE)结合蛋白质1类似于小鼠Glt3或D.malanogaster转录因子IIB二价阳离子耐受蛋白质CUTA丝氨酸/苏氨酸激酶16谷胱甘肽S-转移酶θ1KIAA0107基因产物   115.1679352.5251417.4586354.3599282.4791258.2862562.6142234.3184264.7024365.8881493.9011379.1943323.6471309.3486337.7358367.4893324.9333400.1718288.8083390.5307556.3676458.6886505.0182516.4046512.4055462.592359.9248298.6981364.1875327.8121475.6485   276390432523443510460240270379276303325596352489318364483584383481450432372312485304379533506   458.8586459.2935460.2425460.3326460.352462.033462.4054463.6916464.4612464.9697465.7709466.1997466.8724468.0924469.9502471.1924471.2741472.5359473.0084474.2762474.593477.1999478.4787478.8033480.2708480.5079480.8661481.136481.1652481.9461482.3327   283.3006400.6864436.6589445.8286395.1258409.9513494.9234312.5841333.1906403.197411.9427382.8783371.8858457.7257386.6911442.4205371.3427412.2837415.0843483.0992471.3877472.2313477.7496475.788454.7764418.2868442.0882361.3342408.0382447.6268488.0851   1.99E+003.82E-011.41E-013.77E-017.05E-018.39E-01-2.83E-019.85E-018.11E-013.46E-01-8.46E-022.98E-015.29E-015.98E-014.77E-013.59E-015.36E-012.40E-017.12E-012.80E-01-2.29E-015.71E-02-7.79E-02-1.09E-01-9.34E-025.48E-024.18E-016.88E-014.02E-015.56E-012.01E-02   1.26E+001.47E-015.03E-025.61E-016.48E-019.80E-01-2.91E-013.30E-023.08E-024.98E-02-8.39E-01-3.22E-016.63E-039.45E-016.13E-024.11E-01-3.19E-02-1.36E-017.43E-015.82E-01-5.38E-016.79E-02-1.67E-01-2.57E-01-4.63E-01-5.69E-014.32E-012.62E-025.66E-027.02E-019.00E-02   1111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  P17174P13798Q9P2R8Q9UNT1O75607O94925O95390O75956O95573Q9BXH1P13662Q92793Q9P0H6Q9P0R3O75094Q9P011Q92504O95190Q9Y230Q9BSG0Q9Y366Q14094P43403P52803O95402O00233Q9H1K6Q9BXL6Q9H173   N07ab4K16ab2E15ef4E20cd7L11cd7B20gh1A06ab3K13cd6I23ab5N23gh6L20cd5H05ab5K23ef4C05ef3E11gh1P10ef2M12cd4L12cd8N12cd6M16gh8I17ef2O24ef5H04ef5H23ef7E18cd5L23ab8O18gh7K15gh6H03gh5   谷氨酸-草酰乙酸转氨酶1；可溶性(天冬氨酸转氨酶1)N-酰基氨基酰基-肽水解酶畸形/NIK相关激酶RAB；RAS癌基因家族成员样2B核质蛋白/核质蛋白；3谷氨酰胺酶生长分化因子11在口腔癌中缺失的肿瘤抑制基因相关1脂肪酸辅酶A连接酶；长链3BcI-2结合成分3核转运因子2CREB结合蛋白质(鲁宾斯坦-泰比综合征)AD-012蛋白质假定蛋白质HSPC213slit同系物3(果蝇)非经典泛素缀合酶1HLA II类区表达的基因KE4鸟氨酸脱羧酶抗酶蛋白2RuvB样2(大肠杆菌)染色体2开放阅读框7染色体20开放阅读框9细胞周期蛋白Iζ链(TCR)相关蛋白质激酶(70kD)ephrin-A5Sp1转录活化所需辅因子；亚基7(70kD)蛋白酶体(前体；macropain)26S亚基；非ATP酶；9中胚层发育候选物1半胱天冬酶补充结构域蛋白质14内质网伴侣蛋白SIL1；酵母同系物   412.5293365.1218469.5725268.916350.2387410.4357264.606524.962354.1387493.3887392.576468.559406.4789339.0916345.9855460.4398251.7256421.0592342.0841324.5321278.1968407.6242396.0583357.5339106.0683581.8818432.735425.1251456.5646   22435151134727247132448217443347947446950943953833944130045845335439631658.7399560523449   484.4384484.44484.515484.9919485.5671486.8946489.3912489.6212489.6455492.1083492.4942494.3525495.1858495.2656496.3612497.256497.6138497.6839497.7767497.8462498.3057499.6223500.6282501.0718501.9814502.2082502.7516502.8514503.5156   373.5229400.3314488.4865366.9843369.1972456.0458359.3416498.9664339.2885472.8963454.7336478.8243456.7944447.9021426.952498.5084362.6669453.1247379.9805426.9191409.8539420.31430.7684391.4643222.265494.287498.6205483.629469.6418   2.32E-014.08E-014.52E-028.51E-014.71E-012.46E-018.87E-01-1.01E-014.67E-01-3.75E-033.27E-017.73E-022.85E-015.47E-015.21E-011.11E-019.83E-012.41E-015.41E-016.17E-018.41E-012.94E-013.38E-014.87E-012.24E+00-2.12E-012.16E-012.42E-011.41E-01   -8.84E-01-5.51E-021.23E-013.68E-01-3.66E-011.98E-012.92E-01-1.22E-01-1.02E+00-1.88E-012.87E-011.53E-022.06E-015.87E-013.42E-012.24E-014.28E-016.55E-02-1.89E-014.98E-017.04E-01-2.05E-01-1.60E-03-1.79E-01-8.52E-01-5.45E-013.73E-012.99E-01-2.46E-02   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NV83P11926Q04743Q9BVK2O43251Q99829O95777Q9UN53P24310Q9H929P10768O95287Q01105Q9UK45P35611O14681P80303Q9NWC0P00367O00469Q9UI04P20338Q9HCU8P00519Q13880P25789O43805   H03gh3A12ab8D23ef1G11gh6I16ef3L13cd4B10ef2C19ef2F03ab4N09gh5K19ef1D17cd5H18cd1B08ef2I17ab2K22cd5A05cd1N19gh2B06ab5I09ab8M18ef4N08ab8I19gh4I06ef5O02cd5L13ef7J16cd3   假定蛋白质FLJ10876鸟氨酸脱羧酶1空气孔同系物2(果蝇)类似于推断的葡糖基转移酶的假定蛋白质MGC2840RNA结合基序蛋白质9copine IU6snRNA相关Sm样蛋白质LSm8钙结合蛋白质Cab45前体细胞色素c氧化酶亚基VIIa多肽1(肌肉)假定蛋白质FLJ13055酯酶D/甲酰-谷胱甘肽水解酶高尔基体自身抗原；高尔基体亚家族a；5SET易位(髓系白血病相关)U6snRNA相关Sm样蛋白质LSm7内收蛋白1(α)鬼臼亚乙苷诱导的mRNAnucleobindin 2仅有F盒的蛋白质4谷氨酸脱氢酶1前胶原-赖氨酸；2-酮戊二酸5-加双氧酶(赖氨酸羟化酶)2线粒体核糖体蛋白质L13RAB4A；成员RAS癌基因家族聚合酶(DNA指导的)；δ4v-abl Abelson小鼠白血病病毒癌基因同系物1脑及生殖器官表达的(TNFRSF1A调节子)蛋白酶体(前体；macropain)亚基；α型；4斯耶格伦氏综合征核自身抗原1   423.9423591.3922531.3866388.8682346.6445355.3783391.981327.721184.0695387.341596.3068346.1135328.6513388.4486435.0349451.5599296.1418434.5394360.6735.8327364.1383487.9427513.52232.4636572.4849436.5895368.0123   497362311383530268311407288500102560403551519324236477303238336457431301263534539   504.9702505.3016505.7367505.9804507.0674508.4915508.8683509.3316509.4504510.1197510.5002510.6433511.1477511.9386512.6447516.5292516.7037517.7728518.2525518.6446520.377520.7608522.5153522.7624523.9906526.397526.5215   475.4325486.3355449.3322425.9595461.1452377.1688403.8183414.6963327.1972465.7217402.8142472.3714414.2142483.7088488.7819430.8211349.5918476.3476394.0342497.4006406.7523488.5317489.0161352.0574453.0588498.9408477.7167   2.52E-01-2.27E-01-7.14E-023.80E-015.49E-015.17E-013.77E-016.36E-011.47E+003.97E-01-2.24E-015.61E-016.37E-013.98E-012.37E-011.94E-018.03E-012.53E-015.23E-01-5.05E-015.15E-019.39E-022.51E-021.17E+00-1.28E-012.70E-015.17E-01   2.30E-01-7.07E-01-7.73E-01-2.18E-026.12E-01-4.09E-01-3.36E-013.13E-016.46E-013.67E-01-2.55E+006.95E-012.94E-015.04E-012.54E-01-4.77E-01-3.28E-011.34E-01-2.50E-01-1.63E+00-1.17E-01-9.49E-02-2.53E-013.73E-01-1.12E+002.90E-015.50E-01   111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  O75817Q9UBI1P03950P78423Q9P1D0P03999O95793P22750Q9NRX8Q9UHQ3Q96S52Q9H3F6P37198Q9H1D4O75350Q9P024Q9Y224Q13361Q02535O95864P53621P35638P22307Q92543P78330Q9UNX3P49189Q9ULX0O15353   A13cd6N11cd7G12ab2F20cd1E07gh4K05ab3M22cd2M05ef2B06gh8J15gh4J20gh4J22gh8C24gh8K03cd8B05gh4K04cd5D16ef3H21ef2O12cd3F01ef1L24cd4H16ab4N03ab4D22cd1D15gh1N06ab8G15ef2C10ab2H03gh6H21cd3  POP7(前体加工；酿酒酵母)同系物BUP蛋白质血管生成素；核糖核酸酶；RNaseA家族；5可诱导小细胞因子亚家族D(Cys-X3-Cys)；成员1(fractalkine；neurotactin)假定蛋白质PRO2533视蛋白1(锥细胞色素)；短波敏感性(色盲；蓝色盲)staufen；RNA结合蛋白质(果蝇)RAB4B；成员RAS癌基因家族泛素UBF-fl氧化还原酶UCPA基质细胞蛋白质磷脂酰肌醇聚糖；S类MSTP028蛋白质核孔蛋白62kD精氨酰氨肽酶(氨肽酶B)糖蛋白；染色体接合2亨廷顿互作蛋白质KCGI-99蛋白质微原纤维相关糖蛋白2DNA结合抑制剂3；显性负相螺旋-环-螺旋蛋白脂肪酸去饱和酶2coatomer蛋白质复合物；亚基αDNA损伤诱导性转录物3固醇载体蛋白质2KIAA0254基因产物磷酸丝氨酸磷酸酶核糖体蛋白质L26样1醛脱氢酶9家族；成员A1无机焦磷酸酶有翼螺旋裸露   375.1187337.1018395.0198201.96558.04051116.5093417.7687297.3584431.0731168.7047469.8784404.9498442.9007428.2961430.3273480.7082369.5132449.089194.2884.05787298.4502409.2779322.5942354.3674328.3511253.4253401.3697446.252488.3446407.9375   43342820074773.337.9498346472523214287396499477436480472354174113471318356356220445277402497   526.6432526.9646527.7882530.2357531.5331532.8048534.8626538.4665540.8482544.0864546.1893546.8906549.0707550.8083551.8541552.8489553.5493554.6607557.066559.513559.6571560.6313565.361569.1558569.5472569.9825572.3441579.314579.6142580.6191   445.0255430.701374.4251493.2272220.9467229.0786483.6536393.9782481.1517411.9671410.1503412.8095462.5636492.7531486.2744489.9278467.714492.0453368.553272.6788323.8122480.1571401.9484426.421417.8592347.8406472.8205434.2707489.9828495.2368   4.89E-016.45E-014.18E-011.39E+003.20E+002.19E+003.56E-018.57E-013.27E-011.69E+002.17E-014.34E-013.10E-013.63E-013.59E-012.02E-015.83E-013.05E-011.52E+002.73E+009.07E-014.54E-018.09E-016.84E-017.95E-011.17E+005.12E-013.76E-012.47E-015.09E-01   2.08E-013.45E-01-9.79E-011.89E+003.36E-01-1.62E+002.54E-012.19E-011.29E-011.63E+00-1.13E+00-4.99E-01-1.63E-012.21E-011.47E-01-1.40E-013.78E-017.30E-028.67E-011.05E+00-1.40E+002.01E-01-2.12E-025.58E-031.15E-01-2.03E-011.48E-01-6.87E-01-2.81E-012.85E-01   111111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q9NRP2Q16280P04183Q12824Q99719P46100Q16610P39656P53814Q9P0N4Q9BXZ1Q9Y2Q4O15527Q04323P12004Q99720P43307Q9H3Y8Q9NRX2Q9P2X0Q9Y5Z8P78524P55145P33551Q9BVQ0P34897Q9Y5B4Q9Y2V5Q13953   D21gh4E18ef1C04cd2O17ef5B09ab8H07ab3O05ab5E23ab6G07cd3P24ef1A02gh7H19ef8A18ab8G01ef2G18ab8M11cd6G13cd2O05gh6A08gh5L10gh2E05cd7F01cd2F02ab2O23ab5E09gh6D15cd2L23ef2B15ef2B19cd2   DC13蛋白质环核苷酸门通道α2胸苷激酶1；可溶性SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族b；成员1花生样1(果蝇)α地中海贫血/精神障碍综合征X连锁(RAD54同系物；酿酒酵母)细胞外基质蛋白质1多萜基二磷酸寡聚糖蛋白葡糖基转移酶smoothelin假定蛋白质LOC51260肽酰脯氨酰异构酶(亲环蛋白)样3HSPC002蛋白质8-氧代鸟嘌呤DNA转葡糖基酶ORF增殖细胞核抗原σ受体(SR31747结合蛋白质1)信号序列受体；α(易位子相关蛋白质α)染色体20开放阅读框149线粒体核糖体蛋白质L17多萜基磷酸甘露糖基转移酶多肽3雄性特异性致命3样1(果蝇)抑制致瘤性5富含精氨酸；早期肿瘤中突变CDC28蛋白激酶1假定蛋白质MGC5363丝氨酸羟甲基转移酶2(线粒体)雄激素诱导蛋白质转化生长因子β1诱导的转录物1溶质载体家族12(钾/氯转运蛋白)；成员4   382.8544464.0608346.7317218.8831419.5269309.8648238.3172433.6719517.4102609.9142465.4301337.5615330.4852497.159332.1465363.8609226.1566221.2984284.6282285.542361.7331343.4117413.1582296.353343.30788440.9652268.4081249.1479342.5865   42136028955441016733536726928636239128225530337932224630543139428942035554.5290519327428   581.5421584.8035588.3101590.2326592.2598594.3041596.1691598.0668598.16601.9324603.8737604.9187605.3444610.1121612.821615.0729618.9554619.4944627.9834638.6696639.7431643.333656.6324671.4891681.2449685.6584685.9395712.3879729.2688   461.731469.6748407.8979454.3734474.0479356.9983389.6774466.4028461.5158499.258477.1895444.641406.0683454.2076416.0883452.6168389.0352362.4108405.9846451.8107465.0297425.1425496.4892440.861259.6855472.1838491.1814429.636499.9658   6.03E-013.34E-017.63E-011.43E+004.97E-019.40E-011.32E+004.64E-012.09E-01-1.90E-023.76E-018.42E-018.73E-012.95E-018.84E-017.57E-011.45E+001.49E+001.14E+001.16E+008.23E-019.06E-016.68E-011.18E+003.98E+006.37E-011.35E+001.52E+001.09E+00   1.36E-01-3.66E-01-2.64E-011.34E+00-3.19E-02-8.93E-014.89E-01-2.39E-01-9.44E-01-1.09E+00-3.62E-012.14E-01-2.27E-01-9.61E-01-1.31E-015.85E-025.10E-011.55E-011.01E-015.95E-011.22E-01-2.50E-012.26E-022.59E-013.32E-01-6.05E-019.52E-013.94E-013.21E-01   11111111111111111111111111111   恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低恒低
  Q92686O60565Q9Y4M4P16581O14733Q16623Q9P1M5O60613Q16698Q9HBA8Q9P0I2Q9UL53P49902O95336Q03393Q13443O75173P51572P42765P24666Q92688O14639O15143O15509O15511   I11ef6J05cd8I21gh3E01ef7P02ef5M24cd2P12gh3L18cd4M07ab4D23gh1M13ef4P24cd7N16cd7P09cd7A23ab8P01ef7F15ab2O03gh1D03ab2E05ab2D21cd6B21ab2F06ab2F12ab2F14ab2   neurogranin(蛋白质激酶C底物；RC3)半胱氨酸超家族1；BMP拮抗剂1推断的UDP-GalNAc：多肽N-乙酰半乳糖胺基转移酶T9选择蛋白E(内皮细胞粘附分子1)促分裂原活化蛋白激酶激酶7突触融合蛋白1A(脑)含WW结构域氧化还原酶15kDa含硒蛋白质2；4-dienoyl辅酶A还原酶1；线粒体24-脱氢胆固醇还原酶30kDa蛋白质5′-3′外切核酸酶25′-核苷酸酶；细胞溶质II6-磷酸葡萄糖酸内酯酶6-丙酮酰基四氢生物蝶呤合酶解聚素及金属蛋白酶结构域9(meltrinγ)解聚素样及带有1型凝血酶敏感素基序的金属蛋白酶；4辅助蛋白质BAP31/BAP29乙酰辅酶A酰基转移酶2(线粒体3-oxoacyl-辅酶A硫解酶)酸性磷酸酶1；可溶性酸性(富含亮氨酸)核磷蛋白32家族；成员B肌动蛋白结合LIM蛋白质肌动蛋白相关蛋白质2/3复合物；亚基1B(41kD)肌动蛋白相关蛋白质2/3复合物；亚基4(20kD)肌动蛋白相关蛋白质2/3复合物；亚基5(16kD)   330.8792106.6904346.098109.309498.83312403.233738.931220.902469.9997768.0888546.352648.1321040.523524.3104358.05911306.754786.5151985.1381849.60411642.966470.85751351.973696.0033909.0832732.1996   29915125137814016519.311107062786916041220755700481106088912801970289393513889619   736.2348781.0154846.4309875.1666888.014926.50221292.231285.07615.3087626.0195614.5795430.2235440.0817812.5955517.4355445.36631254.804656.65541204.1311890.909835.9103358.779349.0474807.751466.1372   455.4495346.3594481.2315454.0605375.5944498.3425450.14261205.045597.2594557.2677617.4113560.6322900.9404697.4428525.0184744.50371033.446843.69431111.3291833.204531.9498701.2899519.3549868.6913605.8842   1.15E+002.87E+001.29E+003.00E+003.17E+001.20E+005.05E+007.39E-023.89E-01-2.95E-011.70E-01-5.91E-01-1.24E+006.32E-015.31E-01-1.55E+006.74E-01-5.85E-015.03E-012.03E-018.28E-01-1.91E+00-9.96E-01-1.71E-01-6.51E-01   -1.45E-015.05E-01-4.63E-011.79E+005.02E-01-1.29E+00-1.01E+00-1.38E-015.88E-01-1.47E+003.39E-01-1.03E-012.32E-015.27E-019.66E-01-1.44E+004.29E-01-1.48E-015.92E-012.59E-01-7.04E-01-1.78E+00-4.40E-01-3.18E-02-2.42E-01   1111111222222222222222222   恒低恒低恒低恒低恒低恒低恒低恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P12718Q9P0I6O43747P20172O14617P07741P00568Q9UIJ7P30566Q16186Q9NVF6P26438P40616P36404P56559P35368P15144P30038P14550O43488P09972O43590Q08117Q13438O96018Q13564   A08ab6O09ef4M13ab2A11ab6H07ab2M24ab2A02ab2I06ef2M07ab2M11cd7B19gh3B04ab2D12ab2D14ab2D20ab2K17ab2G24ab2L09ab2L05ab2L07ab2C16ab2G12ef4M19ab2G05cd7M01gh1P11ab2 肌动蛋白；γ2；平滑肌；肠道AD-015蛋白质接头相关蛋白质复合物1；γ1亚基接头相关蛋白质复合物2；μ1亚基接头相关蛋白质复合物3；δ1亚基腺嘌呤磷酸核糖转移酶腺苷酸激酶1腺苷酸激酶3α样腺苷酸基琥珀酸裂解酶粘附调节分子1ADP核糖基化因子1GTP酶活化蛋白质ADP核糖基化因子6ADP核糖基化因子样1ADP核糖基化因子样2ADP核糖基化因子样7肾上腺素能；α-1B-；受体内氨酰(膜)氨肽酶(氨肽酶N；氨肽酶M；微粒体氨肽酶；CD13；p150)醛脱氢酶4家族；成员A1醛-酮还原酶家族1；成员A1(乙醛还原酶)醛-酮还原酶家族7；成员A2(黄曲霉毒素乙醛还原酶)醛缩酶C；果糖二磷酸α辅肌动蛋白-2-相关LIM蛋白质split氨基端增强子在骨肉瘤中扩增淀粉状蛋白β(A4)前体蛋白质结合；家族A；成员3(X11样2)淀粉状蛋白β前体蛋白质结合蛋白质1；59kD   585.3438947.03661104.3321286.83679.48471885.0652404.119758.7288495.8874622.3901449.3679732.1241827.18981751.048485.45621433.715987.33431179.797555.464546.409878.5714776.37571779.707658.0513762.3898587.5144   84683753212804958623991060622610623818122015505981510222598886525105010701430638750664   2095.961259.571419.47122285.193357.0868823.8455354.3768662.8834518.4238574.5888676.1878876.92771141.921871.661568.68241335.995480.1162657.4315609.9901748.5424947.5062501.19931219.695802.34071117.682786.6426   1175.8561014.448685.29571617.354510.49941190.4681052.361828.3999545.4304602.2578582.9297809.13421064.0161723.74550.57641426.069563.2289811.7082683.9189606.6855960.156783.8831476.318699.6136876.6611679.5497   1.84E+004.11E-01-1.40E+008.28E-01-9.28E-01-1.19E+00-2.76E+00-1.95E-016.41E-02-1.15E-015.90E-012.60E-014.65E-019.61E-022.28E-01-1.02E-01-1.04E+00-8.44E-011.35E-014.54E-011.09E-01-6.31E-01-5.45E-012.86E-015.52E-014.21E-01   5.32E-01-1.79E-01-1.05E+00-7.63E-03-4.57E-01-1.13E+00-2.59E+004.87E-013.27E-01-2.95E-024.72E-011.61E-015.64E-01-1.77E-013.00E-017.34E-02-2.15E+00-9.81E-016.74E-01-5.74E-022.63E-014.68E-01-3.16E-01-4.36E-02-2.38E-021.78E-01   22222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9Y679Q9UKB4Q13725P08133P20073P03971P30041P27695Q9Y4J7Q9Y5L7O94778O15296P48444P00966P42024O43681Q9ULX3O96030P15289P08243O95630O95135O14530P30049Q9UII2Q9Y5K8   B08cd7B12ef2H19ab2I20ab2I22ab2E22ab2O08cd5K06ef6P01ab2L03ef2O14ab2E02ab2O18ab2J24ab2D15ab2J16ab2E02ef4H16ab2F24ab2J18ab2L17ab2B09ab2N15ab2N20ab2I10ef2F17ef2   远古遍在蛋白质1angiomotin样2血管紧张肽受体1膜联蛋白A6膜联蛋白A7抗苗勒管激素抗氧化蛋白质2(无硒谷胱甘肽过氧化物酶；酸性钙非依赖性磷脂酶A2)APEX核酸酶(多功能DNA修复酶)凋亡抑制剂5凋亡相关蛋白质APR-3水通道8花生四烯酸15-脂肪加氧酶；第二型archain 1精氨基琥珀酸合成酶ARP1肌动蛋白相关蛋白质1同系物A；中心体肌动蛋白α(酵母)arsA亚砷酸盐转运蛋白；ATP结合；同系物1(细菌)ART-4蛋白质artemin酰基硫酸酯酶A天冬酰胺合成酶具有STAM SH3结构域的相关分子ataxin 2相关蛋白质细胞分化相关的ATP结合蛋白质ATP合成酶；H+转运；线粒体F1复合物；δ亚基ATP酶抑制剂前体ATP酶；H+转运；溶酶体34kD；V1亚基D   1191.741523.72531495.332253.0936650.15911140.8121248.922665.98541850.534662.91221475.036826.82091291.8711049.6881054.286540.3448728.7274881.78491639.546891.3027660.3522902.4529827.4646625.0408776.4612998.0597   12707761360413481948116065368.458314206071200160017207245957281230643872345139046812201670   1022.771568.87661058.942879.9474420.4945640.71583067.945835.6897147.41861426.4891474.307720.21051374.223949.48891777.944595.3348509.3934638.20161012.1211540.113729.2383342.3299766.257441.4691641.27871029.886   1160.442622.72911304.886515.5041517.0979909.92471824.225718.2149688.7802890.77291455.01718.13341288.6491199.5481518.804620.0089611.0757749.3631294.1721024.719753.7548530.0852993.482511.6658878.53411232.91   -2.21E-011.19E-01-4.98E-011.80E+00-6.29E-01-8.32E-011.30E+003.27E-01-3.65E+001.11E+00-7.13E-04-1.99E-018.92E-02-1.45E-017.54E-011.40E-01-5.17E-01-4.66E-01-6.96E-017.89E-011.43E-01-1.40E+00-1.11E-01-5.02E-01-2.76E-014.53E-02   8.81E-025.66E-01-1.36E-017.08E-01-4.36E-01-2.67E-01-1.12E-01-2.85E-02-4.76E+00-1.86E-01-5.92E-02-4.45E-01-1.07E-016.08E-017.10E-014.23E-01-2.92E-01-2.76E-01-4.14E-01-4.72E-014.01E-01-1.39E+007.45E-01-4.16E-016.49E-017.43E-01   22222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O75787P05023P45844Q9HAP7O94812P35613Q9BSR6O00512Q12983Q92934Q07817O43892P53004O60629Q9HBX3P56945O15255P12830P19022P22223P22676Q99828P02593Q13942P27824P17655P04632Q15417Q9UEG5   P15ab2P09ef5P13ef5M08gh5G09ab3B14ef7A20gh8K01ab3E19ab5K24ef1E10ef6M23ab3O19ab3G21ab3N21gh6H23ef3G21cd6C16ef5E03ef7K19ef7N07ab5O19gh1I18ab4L01ab5I05ef1C20ef6C22ef6P17ab5D17ef8   ATP酶；H+转运；溶酶体互作蛋白质2ATP酶；Na+/K+转运；α1多肽ATP结合盒；亚家族G(WHITE)；成员1包含杆状病毒IAP重复7(Iivin)BAI1相关蛋白质3basigin(OK血型)BBP样蛋白质1B-细胞CLL/淋巴瘤9BCL2/腺病毒E1B 19kD互作蛋白质3细胞死亡的BCL-2拮抗剂BCL-2样1双尾D同系物1(果蝇)胆绿素还原酶A膀胱癌相关蛋白质脑及鼻咽癌敏感性蛋白质乳腺癌抗雌激素抗性1CAAX盒1钙粘蛋白1；1型；E-钙粘蛋白(上皮细胞)钙粘蛋白2；1型；N-钙粘蛋白(神经元)钙粘蛋白3；1型；P-钙粘蛋白(胎盘)钙结合蛋白2；(29kD；钙视网膜蛋白)钙及整联蛋白结合1(calmyrin)钙调蛋白1(磷酸化酶激酶；δ)钙调蛋白3(磷酸化酶激酶；δ)钙联结蛋白钙蛋白酶2；(m/II)大亚基钙蛋白酶；小亚基1calponin3；酸性capicua同系物(果蝇)   815.7071299.236863.80681507.1751073.67603.4821816.2191357.15763.7046538.81912062.673654.9397490.0724607.98471672.8761334.88733.68781094.64337.5528896.84671781.1341130.5511076.299902.6671492.644671.59391565.935911.495629.0213   9455173811740983474132076.75487272510414569118054130057792454012001500132078746413708371650603486   1081.688709.0882606.16421945.196826.6524865.2409914.192780.36541991.4529603.51031097.372548.7409512.28071083.41144.023791304.3561202.182489.5012747.1198372.30542116.438838.3709983.6302871.14551543.709549.43651258.047737.1204439.6052   947.5842841.8422616.89571730.54961.2437647.4141015.173504.741767.5569623.22491890.905539.1375523.696956.1289590.29971312.13837.48835.8959541.7151823.69291797.5891096.979949.1389746.01741470.4685.8471490.643750.6841518.1163   4.07E-01-8.74E-01-5.11E-013.68E-01-3.77E-015.20E-011.64E-01-4.08E+003.77E-011.64E-01-9.10E-01-2.55E-016.39E-028.33E-01-5.25E+00-3.34E-027.12E-01-1.16E+001.15E+00-1.27E+002.49E-01-4.31E-01-1.30E-01-5.13E-024.85E-02-2.90E-01-3.16E-01-3.06E-01-5.17E-01   2.13E-01-1.33E+00-1.18E+002.07E-01-1.27E-01-3.50E-016.88E-01-4.15E+00-4.80E-014.33E-012.85E-01-6.63E-012.15E-019.53E-01-4.95E+00-4.14E-02-3.48E-01-2.45E-016.79E-014.22E-01-2.52E-012.26E-01-4.51E-01-9.59E-01-1.19E-013.17E-017.36E-02-5.95E-01-3.73E-01   22222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P52907Q9GZX3Q16619Q9UBD9Q15699P48729P48730P19138P49662P21964P26232P35222P07339Q99967P49715P53567O95627Q04900P07766P34810P18582Q16181Q16543   O08ab4N16gh1K01ab4I24cd8M16cd4A22ab6L07ab4L08ef5C12ef6F19ef6K01ef7G07ef7N23ef7C18cd6N17ef6N22ab5B21cd8G02cd4P07ab3A21ab4B21ab5F09ef5H01ef5   加帽蛋白(肌动蛋白丝)肌肉Z线；α1糖类(N-乙酰葡萄糖胺6-O)磺基转移酶6cardiotrophin 1cardiotrophin样细胞因子；神经营养因子1/B细胞刺激因子3软骨配对类同源异型蛋白质1酪蛋白激酶1；α1酪蛋白激酶1；δ酪蛋白激酶2；α1多肽半胱天冬酶4；凋亡相关半胱氨酸蛋白酶儿茶酚-O-甲基转移酶连环蛋白(钙粘蛋白相关蛋白质)；α2连环蛋白(钙粘蛋白相关蛋白质)；β1(88kD)组织蛋白酶D(溶酶体天冬氨酰蛋白酶)Cbp/p300互作反式作用子；具有富含Glu/Asp羧基端结构域；2CCAAT/增强子结合蛋白质(C/EBP)；αCCAAT/增强子结合蛋白质(C/EBP)；γCCR4-NOT转录复合物；亚基4CD164抗原；唾液粘蛋白CD3E抗原；ε多肽(TiT3复合物)CD68抗原CD81抗原(抗增殖抗体的靶标1)CDC10细胞分裂周期10同系物(酿酒酵母)CDC37细胞分裂周期37同系物(酿酒酵母)   848.0436793.10541478.249361.4077747.0317690.8551951.5238483.60622013.957697.5886797.8639969.2521253.011293.915882.9323826.9569606.4629750.30861808.2092460.2271303.144426.66421085.897   68492912208935961150116059724601170717129094716008841160851570141011009384431050   584.7035751.33521559.477489.65921109.834902.94741111.571461.80361017.4251268.869810.2571103.6191133.8792245.1331045.451584.869692.4535673.72342643.7211293.9611598.276751.36231336.155   705.5063824.52531420.784581.3157817.569914.92181073.796513.97021831.4851046.831774.98961121.2771111.3141711.366937.36121191.643716.7046664.59861953.8441617.5861279.761540.34441158.574   -5.36E-01-7.81E-027.72E-024.38E-015.71E-013.86E-012.24E-01-6.66E-02-9.85E-018.63E-012.22E-021.87E-01-1.44E-017.95E-012.44E-019.38E-011.91E-01-1.55E-015.48E-01-9.27E-012.95E-018.16E-012.99E-01   -3.11E-012.28E-01-2.72E-011.30E+00-3.26E-017.36E-012.84E-013.03E-012.90E-017.51E-01-1.54E-014.14E-01-4.04E-013.02E-011.26E-034.92E-014.89E-01-3.97E-01-3.59E-01-1.16E+00-4.75E-015.42E-02-4.35E-02   22222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O14735P30260P49427P29373P41208O00522O15183Q9Y2Z5Q9Y3C3Q9Y3D0Q9Y3E5Q9Y3E8Q9Y320Q9Y357Q9Y360Q9Y512Q9Y390P40227Q99832Q9UBR5Q9UHN8P54105Q14781Q9BXS4Q9NPA0Q9UKR5P56378O95433Q9NV31Q9NVE2Q9UI05Q9P0A7   I14cd6F13ef5B12ef7F01ef7F09ab5F05ab4B12cd3D07ef2J05ef2J11ef2J17ef2C08ef2A19ef2P16ef1A10ef2B04ef3K21ef2N20ab4H07cd6I23ef4N05ef4L07ef5F09ef1K12cd5H07gh4G14cd7M16cd5B22cd7J23gh3D09gh3L04gh4M09ef8   CDP-二酰基甘油--肌醇3-磷脂酰基转移酶(磷脂酰肌醇合酶)细胞分裂周期27细胞分裂周期34细胞视黄酸结合蛋白质2centrin；EF手蛋白质；2大脑海绵状畸形1CGG三联重复结合蛋白质1CGI-06蛋白质CGI-120蛋白质CGI-128蛋白质CGI-147蛋白质CGI-150蛋白质CGI-31蛋白质CGI-40蛋白质CGI-45蛋白质CGI-51蛋白质CGI-81蛋白质包含伴侣蛋白的TCP1；亚基6A(ζ1)包含伴侣蛋白的TCP1；亚基7(η)趋化因子样因子1趋化因子样因子1氯离子通道；核苷酸敏感性；1Achromobox同系物2(Pc类同系物；果蝇)染色体1开放阅读框8染色体11假定蛋白质ORF3染色体14开放阅读框1染色体14开放阅读框2染色体14开放阅读框3染色体15开放阅读框12染色体2开放阅读框6染色体20开放阅读框24染色体20开放阅读框30   241.77931060.812762.58081226.236539.1633870.4309402.949721.67091229.5371592.767532.425785.276745.0314817.7272786.0567967.35081391.9021011.6131190.6441047.631568.851471.0775795.873874.0189998.85771181.962503.5233656.1775853.8367648.492518.951581.9098   118014701300803672631610674136023707889249327699148598024361090180020304877491370834116069056383267121401080   311.74221469.824766.68431350.177676.8582723.1482883.32831177.6412124.3042011.685567.0634778.0449703.7829418.6337796.62291045.6381140.01592.49441548.8741059.4371237.728640.6855713.815904.3066858.7941285.11890.9975438.9755861.2221468.63521201.0511200.665   579.49311334.733942.07841126.373629.3345741.4854632.0808857.64921572.3021992.502629.3057829.1206793.4541668.441832.2061957.42011111.152679.90431274.9831303.9921611.343532.9217753.03051050.603897.33891207.747694.9486552.8428848.9729596.09991952.881954.524   3.67E-014.70E-017.74E-031.39E-013.28E-01-2.67E-011.13E+007.06E-017.89E-013.37E-019.09E-02-1.33E-02-8.22E-02-9.66E-011.93E-021.12E-01-2.88E-01-7.72E-013.79E-011.62E-02-3.42E-014.44E-01-1.57E-014.91E-02-2.18E-011.21E-018.23E-01-5.80E-011.24E-02-4.69E-01-1.07E+001.04E+00   2.29E+004.74E-017.66E-01-6.11E-013.18E-01-4.64E-015.98E-01-9.94E-021.49E-015.75E-015.66E-012.35E-013.22E-01-8.87E-022.17E-01-1.71E-01-7.96E-01-1.22E+00-1.33E-017.85E-013.70E-014.80E-02-8.68E-026.52E-01-2.60E-01-3.18E-024.55E-01-2.20E-01-3.76E-024.96E-02-2.36E-018.93E-01   22222222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9Y3B1Q9BQ89Q96C58Q9Y5Z4Q00610P56749O43809O96005Q16740P55085P13726Q9Y678Q15363O43513Q9Y281P04141P02745P29279O43191Q99627O15387Q9ULV4Q9BR76Q14061Q9Y6B2   H22ef1C01gh8J19gh7K12ef3I12cd5F04cd7M15cd7G05ab4E20cd4O24ab5B05ab4D14ef8M11ef3N06cd4N18cd8G22gh6L06ef1I16ab4B02cd3C01cd7G21cd7K18ef3I14gh7B22cd5E02ef8   染色体20开放阅读框45染色体20开放阅读框55染色体6开放阅读框29染色体6开放阅读框34网格蛋白；重链多肽(Hc)claudin 12断裂及聚腺苷酸化特异性因子5；25kD亚基唇及腭裂相关跨膜蛋白质1ClpP酪蛋白水解性蛋白酶；ATP依赖性；蛋白水解亚基同系物(大肠杆菌)凝血因子II(凝血酶)受体样1凝血因子III(促凝血酶原激酶；组织因子)外壳蛋白γ-cop有被小泡膜蛋白质Sp1转录活化所需辅因子；亚基9(33kD)cofilin 2(肌肉)集落刺激因子2(粒细胞-巨噬细胞)补体成分1；q亚成分；α多肽结缔组织生长因子COP9组成型光形态形成同系物亚基3(拟南芥)COP9同系物COP9亚基6(MOV34同系物；34kD)冠蛋白；肌动蛋白结合蛋白质；1C冠蛋白；肌动蛋白结合蛋白质；1BCOX17同系物；细胞色素c氧化酶装配蛋白质(酵母)CREBBP/EP300抑制蛋白质1   1691.8641460.8751254.647915.38181639.7592262.278640.23011353.338625.8711829.75371079.841815.7993706.3054591.8619671.9394116.2139683.4431596.4123855.8616788.2297590.99731594.037708.5653889.1581946.9513   123095210809881210248050311705289798807388044812701290165053710309683821200108014401030   783.77991221.732480.9999372.31191437.441233.472683.34671394.845475.0848392.7495442.62121009.756870.2118798.87061093.534165.718798.23661071.5171302.3341195.497628.50411362.545690.8568745.86581988.725   1235.1081211.641940.0036758.63661427.5031992.755608.98251304.597543.0367734800.9723854.5161793.6589623.9284678.6369522.7831042.465734.84891062.925984.0634533.82511385.839827.78641026.3741323.308   -1.11E+00-2.58E-01-1.38E+00-1.30E+00-1.90E-01-8.75E-019.40E-024.36E-02-3.98E-01-1.08E+00-1.29E+003.08E-013.01E-014.33E-017.03E-015.12E-012.24E-018.45E-016.06E-016.01E-018.88E-02-2.26E-01-3.65E-02-2.54E-011.07E+00   -4.60E-01-6.17E-01-2.10E-011.10E-01-4.44E-011.34E-01-3.47E-01-2.15E-01-2.45E-012.39E-01-2.94E-01-1.45E-011.88E-01-2.99E-01-1.31E+003.47E+001.27E+00-1.52E-012.68E-012.97E-01-6.30E-01-4.09E-016.13E-017.00E-011.27E-01   2222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9NY68P24385Q9NXT4P01034Q15828P01036P52943P13498P00167P00001P10606P08574Q99426Q07065Q15038Q9H2L4Q9NPA8O60231Q9GZR7P17844Q08211Q9UJV9P51398Q13437O60735Q16854Q9Y295P00387   C06gh4O04ef5K09gh2I11ab6I13ab4C02ab6I05ab4G18ab3C04ab6N24gh6I24gh6P10ab5C17gh1G13cd7L13ef3B18gh8G22gh7H13cd3E02gh4F04ab4M03ab4D08ef2G18ef6G22cd4O06cd6M06ab5H04ab8F09ab3   CTL2基因细胞周期蛋白D1(PRAD1：甲状旁腺腺瘤病1)细胞周期蛋白M2半胱氨酸蛋白酶抑制剂C(淀粉状蛋白血管病及脑出血)半胱氨酸蛋白酶抑制剂E/M半胱氨酸蛋白酶抑制剂S富含半胱氨酸蛋白质2细胞色素b-245；α多肽细胞色素b-5细胞色素c细胞色素c氧化酶亚基Vb细胞色素c-1细胞骨架相关蛋白质1细胞骨架相关蛋白质4DAZ相关蛋白质2DC32DC6蛋白质DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽16DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽24DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽5(RNA解旋酶；68kD)DEAD/H(Asp-Glu-Ala-Asp/His)盒多肽9(RNA解旋酶A；核DNA解旋酶II；leukophysin)DEAD核蛋白质abstrakt死亡相关蛋白质3裂手/裂脚1区中缺失树突细胞蛋白质脱氧鸟苷激酶发育调节的GTP结合蛋白质1黄递酶(NADH)(细胞色素b-5还原酶)   1381.8211214.6111560.6591067.127967.16691261.605874.1939708.99542187.128547.67081364.01667.9346560.9411602.5101808.0755408.0427944.3094753.8815803.421482.642907.5859976.8378920.30441565.344858.6375858.1918736.37861402.134   80421501720970279046649910501480442210044368457589070215708739841440658123098115005028856341030   788.50021100.4781582.7681366.396451.39321069.7561277.819359.31561034.311517.61252087.456441.6771777.32691785.415564.7611780.28781514.164799.6561774.37651670.104907.4343870.3672814.35181721.872467.3432989.3036660.70231435.74   991.49951486.7691620.991134.6121404.267932.4892883.82707.74831565.893502.47861851.225517.4383673.9633987.5887754.4305630.04141342.189808.7915854.09651530.749824.21931024.437905.19041596.672609.2393910.8082676.92671290.593   -8.09E-01-1.42E-012.03E-023.57E-01-1.10E+00-2.38E-015.48E-01-9.81E-01-1.08E+00-8.14E-026.14E-01-5.97E-014.71E-011.57E+00-5.17E-019.35E-016.81E-018.50E-02-5.31E-021.72E-01-241E-04-1.66E-01-1.76E-011.37E-01-8.78E-012.05E-01-1.56E-013.42E-02   -7.81E-018.21E-011.40E-01-1.37E-011.53E+00-1.44E+00-8.08E-015.73E-01-5.67E-01-3.09E-016.24E-01-5.93E-012.85E-01-6.78E-021.40E-017.82E-017.32E-012.11E-012.93E-01-4.26E-02-4.65E-013.28E-019.20E-02-5.88E-02-7.75E-014.43E-02-2.17E-01-4.40E-01   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9UHY9P36957Q99075Q9UFN1O95882Q9Y269Q9NWE3Q9H6Y7Q9Y3X0O60762P53805Q13597Q9C005Q13448Q9UHF9P51452Q14203Q13561Q13409Q09472P78365Q99848Q12805Q9Y6I3Q15717   I08ef2C06ab6M12ef7H10gh6C13ef8C07ef8J11ef8H04gh6P23ef8G19cd4B11ab5N13ef3J05gh8J03cd6K01ef4N22ab4A13ab6D19cd6I16ef1C18ab4D20gh8N19ab4G11cd7A21ab6D21cd8C04ab4   二羰基/L-木酮糖还原酶二氢硫辛酰胺S-琥珀酰转移酶(2-氧代-戊二酸复合物E2组分)白喉毒素受体(肝素结合的上皮生长因子样生长因子)DKFZP564B147蛋白质DKFZP564C1940蛋白质DKFZP564M082蛋白质DKFZP566C243蛋白质DKFZP566H073蛋白质DKFZP586M1019蛋白质多萜基磷酸甘露糖基转移酶多肽1；催化亚基唐氏综合征临界区域基因1卵巢癌下调1dpy-30样蛋白质DR1相关蛋白质1(负性辅因子2α)双氧化酶2双特异性磷酸酶3(牛痘病毒磷酸酶VH1相关)动力蛋白激活蛋白1(p150；glued同系物；果蝇)动力蛋白激活蛋白2(p50)动力蛋白；细胞质部分；中间体多肽2E1A结合蛋白质p300EAF1蛋白质早期发育调节子2(polyhomeotic2同系物)EBNA1结合蛋白质2含EGF的fibulin样细胞外基质蛋白质1EH结构域结合有丝分裂磷蛋白ELAV(胚胎致死性；异常视觉；果蝇)样1(Hu抗原R)   544.2125625.9037721.8431966.5927941.4076675.8991419.56071390.389588.3603407.0059370.0907594.6931810.45851240.3591146.14649.6813507.59421565.567793.32071496.409642.1587894.3715977.86711002.82736.8984850.8493   7407136389478651110770148050558166369312101140648605529138060421206521070611332500800   938.7807393.7165197.1171469.105804.6391208.543625.84831191.195672.4872605.8353511.9248623.7021174.0012382.895316.6462473.5652623.69481173.024464.96751342.944469.6834761.5923818.6583458.9563629.1845843.4463   741.1577.6196518.95251127.658870.3185998.4411605.0841352.292588.5767531.3373515.0794636.9661064.1321586.247703.5318576.1845553.55761372.261620.65061651.644588.0816907.5945802.3778597.7763621.9752831.3485   7.87E-01-6.69E-01-1.87E+006.04E-01-2.26E-018.38E-015.77E-01-2.23E-011.93E-015.74E-014.68E-016.87E-025.35E-019.42E-01-1.86E+00-4.56E-012.97E-01-4.16E-01-7.71E-01-1.56E-01-4.51E-01-2.32E-01-2.56E-01-1.13E+00-2.28E-01-1.26E-02   4.44E-011.88E-01-1.78E-01-2.91E-02-1.22E-017.17E-018.76E-018.55E-02-2.21E-015.14E-018.42E-012.20E-015.76E-01-1.27E-01-8.23E-01-1.02E-016.06E-02-1.84E-01-3.94E-015.00E-012.28E-022.54E-01-6.79E-01-1.60E+00-5.60E-01-8.94E-02   22222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P13804Q14247P42892P30084P07099P29692P20042P41091Q99613P78344P23588Q13541Q13542O60573Q16394P37268P55899Q9UK73P21333P26885Q13451O95633P15407   I24ab3K17ef6O21ab4A17ab6I20ab3H04ab5L05cd4A20ab4L16cd3C02ab4A24ab4C03ab5A19ab6G16cd5K02ab3C17ab6L22ab5P05ef3G14ab4P07ab4F15ab4M01cd6A20cd4 电子转移黄素蛋白；α多肽(戊二酸尿II)ems1序列(乳房肿瘤及鳞状上皮细胞癌相关(p80/85src底物)内皮素转换酶1烯脂酰辅酶A水合酶；短链；1；线粒体环氧化物水解酶1；微粒体(异生素)真核翻译延伸因子1δ(鸟嘌呤核苷酸交换蛋白质)真核翻译起始因子2；亚基2(β；38kD)真核翻译起始因子2；亚基3(γ；52kD)真核翻译起始因子3；亚基8(110kD)真核翻译起始因子4Y；2真核翻译起始因子4B真核翻译起始因子4E结合蛋白质1真核翻译起始因子4E结合蛋白质2真核翻译起始因子4E样3exostoses(多发性)1法呢酰二磷酸酯法呢酰基转移酶1IgG的Fc片段；受体；转运蛋白；αfem-1同系物b(线虫)细丝蛋白A；α(肌动蛋白结合蛋白质280)FK506结合蛋白质2(13kD)FK506结合蛋白质5卵泡抑素样3(分泌糖蛋白)FOS样抗原1   918.83911135.188602.4294802.31141231.481329.7561489.433742.58431140.0221562.9521343.0191655.9261620.111799.7789513.7526726.0862450.8629548.2677946.0465814.63571366.9051312.1741696.135   5451050799121018407446034748531520101010601850883428455771547675510111012801350   529.28661002.084809.7071741.22261198.1691110.87956.276478.7249998.74881177.8451125.8252293.2361663.197819.3679813.2693649.0518476.1039530.8011277.458661.4593812.85681092.991218.491   664.35331063.9737.1982917.95481424.6611061.6311016.24565.2535997.20111419.6651160.6591669.8731712.605833.9147584.9471610.2023566.0193541.9489966.2982662.03871097.2481227.5571421.01   -7.96E-01-1.80E-014.27E-01-1.14E-01-3.96E-02-2.59E-01-6.39E-01-6.33E-01-1.91E-01-4.08E-01-2.54E-014.70E-013.79E-023.49E-026.63E-01-1.62E-017.86E-02-4.67E-024.33E-01-3.01E-01-7.50E-01-2.64E-01-4.77E-01   -7.54E-01-1.06E-014.08E-015.93E-015.83E-01-8.37E-01-1.30E+00-6.46E-01-4.19E-01-4.19E-02-4.07E-01-6.43E-011.95E-011.42E-01-2.64E-01-6.73E-017.74E-01-3.93E-03-4.86E-01-6.76E-01-2.98E-01-3.86E-02-3.31E-01   22222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q14192Q9NZA0P35637Q9Y653Q9H1C0P15170O95166O08765P16278P78537P31150P06396P52657Q00403P48060P06744P30101O43836P15104Q06210Q9Y3D4Q9Y2Q3P48637P78417P49840P13224Q9UBQ7   G02ab4N17gh6P19ab4E21gh7B02cd5E18gh4L13ab4D09cd7D21cd7O05ef1J23ab4F14ab4B23ab3E03ab6F08ef6I23cd7B19ab3G13ab5I22ef1H22ab5A23ab5M19ef2C24ef2D01ab3E20cd5J14ef4F23ab3L08cd7   四个半LIM结构域2fuse结合蛋白质互作阻遏物融合蛋白；源自t(12；16)恶性脂肪肉瘤包含FXYD结构域的离子转移蛋白调节子7G蛋白偶联受体56G蛋白偶联受体92G1-S期转变1GABA(A)受体相关蛋白质GABA(A)受体相关蛋白质样2半乳糖苷酶；β1GCN5普通控制的氨基酸合成5样1(酵母)GDP解离抑制因子1凝溶胶蛋白(淀粉样变性；芬兰型)普通转录因子IIA；2(12kD亚基)普通转录因子IIB神经胶质瘤病变相关蛋白质葡萄糖磷酸异构酶葡萄糖调节蛋白质；58kD谷氨酸受体；互变异构；N-甲基D-asparate相关蛋白质1(谷氨酸结合)谷氨酸氨连接酶(谷氨酰胺合酶)谷氨酰胺-果糖-6-磷酸转氨酶1谷氧还蛋白2谷胱甘肽S转移酶亚基13同系物谷胱甘肽合成酶谷胱甘肽S转移酶样；谷胱甘肽转移酶ω糖原合酶激酶3α糖蛋白1b(血小板)；β多肽乙醛酸还原酶/羟基丙酮酸还原酶   309.9219924.2347866.3996942.61262010.489712.10072042.4251280.4951241.27539.4222813.3309633.6157330.1567538.6557500.4565676.4844900.97721708.6581729.7771170.59869.494888.5406841.3959650.84961983.6261057.368487.4684947.0262   5919116541060216075014102210113080063789457768579169255312501890104060089434642920201460530977   1210.6351110.4681159.792802.86791501.617719.79991109.7211227.378918.8337656.0518919.5196640.108633.2269700.1857454.8328752.7928726.47492220.1051655.1311180.088863.1571099.209414.7892488.66631805.4891247.816653.4727997.593   703.7424981.791893.3381935.66661889.081727.28691521.2261572.361095.839665.3025790.0409722.7008513.4286641.1721582.2035707.2232726.76881726.6681758.8531130.151777.6585960.4756533.8957522.96851937.8881254.087557.0977973.9926   1.97E+002.65E-014.21E-01-2.32E-01-4.21E-011.55E-02-8.80E-01-6.11E-02-4.34E-012.82E-011.77E-011.47E-029.40E-013.78E-01-1.38E-011.54E-01-3.11E-013.78E-01-6.36E-021.17E-02-1.06E-023.07E-01-1.02E+00-4.13E-01-1.36E-012.39E-014.23E-017.50E-02   9.30E-01-2.13E-02-4.06E-011.71E-011.00E-017.47E-02-5.33E-017.87E-01-1.39E-015.69E-01-3.52E-014.97E-018.05E-013.46E-016.61E-013.35E-02-7.05E-01-4.50E-011.29E-01-1.71E-01-5.34E-018.32E-03-1.28E+00-6.00E-012.95E-024.63E-011.22E-014.55E-02   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9P2T1Q9H4A6P28799Q14393P29354Q14451Q9Y6G2P04899P11016Q13905Q16774Q9Y649P07305O75367P17317P02278Q9NS37O96004P10809P34932P07900P08238O75506Q9UHG4P09105O43504Q9H2I6P51858Q04150Q13151P22626   C02ef2I04gh5B19ab5H10ab3H06ef5D20ab4E04ef8J09ab4M13ef5G09ab6L16ab3K16ef4G13ab6M14cd5C24ab6M16gh6A03gh5E02cd5M11ef5I11ef1G18ef7B20ab7H17ab6K18ef4J21ab4D23cd6N10gh5K16ef7A08ab7E15cd7N09ab6  单磷酸鸟嘌呤核苷还原酶同构体GMPR2高尔基磷蛋白3(外壳蛋白)颗粒体蛋白生长抑制特异性6生长因子受体结合蛋白质2生长因子受体结合蛋白质7生长激素诱导性跨膜蛋白质鸟嘌呤核苷酸结合蛋白(G蛋白)；α抑制活性多肽2鸟嘌呤核苷酸结合蛋白(G蛋白)；β多肽2鸟嘌呤核苷酸释放因子2(crk原癌基因特异性)鸟嘌呤核苷酸激酶1GW128蛋白质H1组蛋白家族；成员0H2A组蛋白家族；成员YH2A组蛋白家族；成员ZH2B组蛋白家族；成员GHCF结合转录因子Zhangfei心脏及神经管嵴衍生物表达1热休克60kD蛋白质1(伴侣蛋白)热休克70kD蛋白质4热休克90kD蛋白质1；α热休克90kD蛋白质1；β热休克因子结合蛋白质1血红素调节的起始因子2-α激酶血红蛋白；θ1乙肝病毒x互作蛋白质丙肝病毒核心结合蛋白质6肝癌源性生长因子(高迁移率组蛋白质1样)不均一核内核糖核蛋白A/B不均一核内核糖核蛋白A0不均一核内核糖核蛋白A2/B1   762.01261027.6031611.298484.489721.5894712.32961289.256860.9208758.629410.0949968.58671663.3051780.3531065.311591.0013586.8773857.3143705.51631693.231402.5052405.7932781.4621132.126413.2841702.4451008.655676.7297894.1008943.3857906.9861021.87   1070121017505638548461020139077356913402420187083746185271761210201610143019501300659484134062011708709441010   817.04961209.7831238.745739.1661663.0587636.8962974.2631748.649836.6295535.1889975.89111834.1741746.555455.59671570.489684.6287601.7268621.0331276.411042.1131512.258979.11451081.748576.3971769.2336949.0116473.9328490.74561065.5971143.5521584.855   882.41541148.941532.188595.5619746.3732731.60291093.421334.01789.4586504.611095.9671971.4641797.448786.0181874.2269707.973725.1835646.34011330.2351352.2831783.3741903.9931171.256549.5035651.96921097.672590.1783850.7213959.787998.17031206.298   1.01E-012.35E-01-3.79E-016.09E-01-1.22E-01-1.61E-01-4.04E-011.02E+001.41E-013.84E-011.08E-021.41E-01-2.77E-02-1.23E+001.41E+002.22E-01-5.11E-01-1.84E-01-4.08E-01-4.28E-01-6.70E-01-1.51E+00-6.57E-024.80E-011.31E-01-8.79E-02-5.14E-01-8.65E-011.76E-013.34E-016.33E-01   4.87E-012.35E-011.16E-012.17E-012.44E-012.47E-01-3.43E-016.94E-012.73E-024.71E-014.72E-015.39E-016.73E-02-3.48E-01-3.58E-015.38E-01-2.59E-01-2.04E-01-7.30E-012.01E-01-7.48E-01-5.11E-011.99E-016.73E-01-5.37E-014.05E-01-1.27E-013.85E-01-1.16E-015.77E-02-1.38E-02   2222222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P07910O14979P52597Q07244Q15584P12081Q9UBN7Q13838Q99873Q9H063P51610O00165Q9Y2Q5Q9Y2R0Q9Y2T0Q9UNZ5Q9P032Q9P019Q9P004Q9P003Q9P000Q9Y684Q9NRG2Q16775P40939P55084Q14526Q9UBS2   A10ab7L09cd5G06ab7N13ab6P03ab7J12ab4E11cd6M07cd4H02ef7M14gh8L21ab5I04cd6P24ef7A05ef8A17ef8C17ef8O19ef8A06ef8A24ef8C04ef8C06ef8N09ef2D01gh4G15ab6D07ab3D09ab3B13ab5A15ef1   不均一核内核糖核蛋白C(C1/C2)不均一核内核糖核蛋白D样不均一核内核糖核蛋白F不均一核内核糖核蛋白K不均一核内核糖核蛋白M组氨酰-tRNA合成酶组蛋白脱乙酰基酶6HLA-B相关转录物1HMT1 hnRNP甲基转移酶样2(酿酒酵母)酵母MAF1同系物宿主细胞因子C1(VP16辅助蛋白质)HS1结合蛋白质HSPC003蛋白质HSPC009蛋白质HSPC022蛋白质HSPC023蛋白质HSPC125蛋白质HSPC141蛋白质HSPC160蛋白质HSPC163蛋白质HSPC166蛋白质HSPCO34蛋白质HTGN29蛋白质羟脂酰谷胱甘肽水解酶羟脂酰辅酶A脱氢酶/3-酮脂酰辅酶A硫解酶/烯脂酰辅酶A水合酶(三功能蛋白质)；α亚基羟脂酰辅酶A脱氢酶/3-酮脂酰辅酶A硫解酶/烯脂酰辅酶A水合酶(三功能蛋白质)；β亚基癌中超甲基化1超极化活化的环核苷酸门控钾离子通道2   747.53091057.6991902.939847.6967725.3651555.5578685.5336681.4666890.1184744.9951583.74781482.068620.77831507.005453.0964825.3888558.8905717.90961182.006801.5204508.2074569.95331276.132511.34121814.498539.2691918.3678676.9289   71819901280667569565407604836921580149010101720733131060217001070141092162814706761770890904688   1059.3491646.1721517.274684.4978858.2829424.3904695.1552921.75321209.8721013.86735.16912425.818625.65741784.568326.42151347.488843.09531519.292545.85231148.378523.3806797.48191639.451407.05381617.5781218.1051008.759520.6835   841.66011563.7171567.536733.1055717.4409514.8575595.8457735.5784978.6584893.139632.97861800.489752.1651668.909504.18211159.538668.14351312.254932.76661118.827650.7428665.0441462.8531.48851733.575882.3271943.6552628.6277   5.03E-016.38E-01-3.27E-01-3.09E-012.43E-01-3.89E-012.01E-024.36E-014.43E-014.45E-013.33E-017.11E-011.13E-022.44E-01-4.73E-017.07E-015.93E-011.08E+00-1.11E+005.19E-014.24E-024.85E-013.61E-01-3.29E-01-1.66E-011.18E+001.35E-01-3.79E-01   -5.79E-029.10E-01-5.69E-01-3.46E-01-3.51E-012.34E-02-7.53E-01-1.75E-01-9.05E-023.05E-01-9.25E-031.12E-027.02E-011.87E-016.94E-016.62E-011.08E-011.24E+00-1.43E-018.11E-018.57E-011.39E-012.07E-014.03E-01-3.69E-027.22E-01-2.30E-022.40E-02   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q96EW8Q9Y2S6Q9UKZ1Q9UJJ9O95891Q9UJI9Q9H0U3Q9NWD8Q9NW90Q9NW61Q9NW16Q9NVZ3Q9NVC3Q9H9K7Q9H8H4Q9P0R5Q9NXQ4Q9NXI2Q9NXD5Q9NX64Q9NWX1Q9NWT8Q9NWM3Q9H7C7Q9H6R6Q9H673O95476Q9Y244Q9P022Q9P013Q9P009Q9P0S9Q9NPI0   P08gh8D01ef2I23gh3D21gh8D08ef8F08gh6K20gh8N05gh2P21gh2B18gh2G04gh3G14gh3D23gh3B10gh5H06gh5L02ef1M07gh3M21gh3E18gh2I16gh2A20gh3D11gh2C20gh3D05gh5J23gh5F11gh5H15ef8B23ef2P04ef2P06ef2P14ef2A19ef3A23ef3   假定基因ZD52F10假定蛋白质假定蛋白质C40假定蛋白质CAB56184假定蛋白质CL25022假定蛋白质DJ328E19.C1.1类似于植入相关蛋白质的假定蛋白质DKFZp564K142假定蛋白质FLJ10099假定蛋白质FLJ10211假定蛋白质FLJ10297假定蛋白质FLJ10374假定蛋白质FLJ10420假定蛋白质FLJ10815假定蛋白质FLJ12681假定蛋白质FLJ12800假定蛋白质FLJ14868假定蛋白质FLJ20113假定蛋白质FLJ20234假定蛋白质FLJ20309假定蛋白质FLJ20419假定蛋白质FLJ20552假定蛋白质FLJ20608假定蛋白质FLJ20739类似于Rbig1的假定蛋白质FLJ21044假定蛋白质FLJ21952类似于基因捕获PAT 12的假定蛋白质FLJ22548假定蛋白质HSA011916假定蛋白质HSPC014假定蛋白质HSPC138假定蛋白质HSPC148假定蛋白质HSPC155假定蛋白质HSPC194假定蛋白质HSPC196   727.44331188.199657.2427432.4911675.1981119.4811287.049754.9838492.5962772.0358756.2846437.6151402.842446.14541058.023702.18411503.987643.4985617.1482938.89581366.306980.6383381.202551.5395425.31521394.8251310.0971668.101666.1765916.52141031.6581336.172280.0356   605149061469520709351080758551844543702928657775684152087714208251800915593708396122010401530521145013301570644   223.80141593.015506.0272601.251477.5231005.6911145.302710.8818601.7235620.8513467.9722362.923598.595593.56061421.8941117.1681545.141178.0291758.0334981.63591533.352907.2393689.893585.1487679.1125530.56461485.6841243.802643.59791133.279662.24811957.055672.086   518.58581423.596592.3978576.35251741.8411019.9241169.228741.1753548.3816745.7235589.0741500.7932976.6359565.60721084.852834.45211521.653566.3149932.5386915.23991565.249934.2965554.671615.0164500.05381047.1341279.9621481.658610.09931167.031008.2181622.151532.0086   -1.70E+004.23E-01-3.77E-014.75E-01-1.81E-01-1.55E-01-1.68E-01-8.68E-022.89E-01-3.14E-01-6.93E-01-2.70E-01-1.23E+004.12E-014.26E-016.70E-013.89E-02-1.85E+002.97E-016.42E-021.66E-01-1.12E-018.56E-018.53E-026.75E-01-1.39E+001.81E-01-4.23E-01-4.97E-023.06E-01-6.40E-015.51E-011.26E+00   -2.67E-013.26E-01-9.84E-026.85E-013.07E-01-2.60E-01-2.59E-015.11E-031.61E-011.29E-01-4.78E-016.81E-01-5.95E-015.59E-01-4.50E-01-3.78E-021.13E-024.47E-011.20E+00-1.86E-013.95E-01-9.99E-026.37E-013.61E-01-1.04E-01-1.98E-01-3.27E-01-1.22E-01-3.56E-016.63E-013.67E-012.36E-011.20E+00   222222222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O95887Q9P0T9Q9P0Q1Q9P0P0Q9P0N9Q9NZD9O75207Q9BWL0Q9BW61Q9BQ49Q9BQD3Q9BQ61Q9BTV4Q9BVX2Q9H773Q9BPX5Q9UJX8P00492P22304Q03827P12268Q9Y6K9Q14573O15357O15503P52945P51460P46977Q13418P48551P15260P38484   C18ef2K02ef2K10ef2K20ef2K22ef2M23ef2M02gh4L24gh7C09gh6K05gh6E17gh6A09gh6O23gh6C17gh6I17gh6L02gh7B09ef3P12cd6I04ab6F02ef6F11ab6P03cd3F04ab6L09ab6B05ab7L13gh6B07ab7D20ab6H08ef5O21ef7A02ef7D12ef5   假定蛋白质LOC51061假定蛋白质LOC51234假定蛋白质LOC51248假定蛋白质LOC51255假定蛋白质LOC51256假定蛋白质LOC51323假定蛋白质LOC57019假定蛋白质MGC：5244；假定蛋白质MGC2594假定蛋白质MGC2747假定蛋白质MGC2749假定蛋白质MGC2803假定蛋白质MGC3222假定蛋白质MGC5576假定蛋白质MGC5627类似于肌动蛋白相关蛋白质2/3复合物的假定蛋白质；亚基5假定蛋白质；雌二醇诱导次黄嘌呤磷酸核糖转移酶1(莱-萘二氏综合征)艾杜糖2-硫酸酯酶(亨特综合征)即早期蛋白质IMP(次黄嘌呤单磷酸)脱氢酶2B细胞中κ轻多肽基因增强子抑制子；激酶γ肌醇1；4；5-三磷酸受体；3型肌醇多磷酸磷酸酶样1胰岛素诱导基因1胰岛素上游因子1胰岛素样3(莱迪希细胞)膜内在蛋白质1整联蛋白连接激酶干扰素(α；β和ω)受体2干扰素γ受体1干扰素γ受体2(干扰素γ转导蛋白1)   777.55911224.056376.82591301.286540.326600.1582663.8685569.88561446.395527.9287841.54991234.395561.6572747.2749799.182583.40761184.3341210.8951197.3650.63581254.916822.3859555.9397997.7512472.02021437.2851227.4591693.4741340.442605.16131165.784593.8133   7091290933219037471564443624606798892170502762819424948233132053756778864611504283700129017909626692600773   551.83541457.5441014.4411904.375604.1319506.8479680.7704732.98911354.586677.2851899.90171980.421583.5781604.3725584.0079632.41011116.899566.09451095.895536.27051293.693807.6888627.61431290.473615.7553746.5141040.8512514.9771599.336389.1781179.083550.2678   679.35961322.295774.6231798.292506.0883607.2015663.0017579.59321754.667628.1009876.89251794.728548.9637704.7101734.1306546.63591083.179669.94371205.085574.48951038.44805.9933609.95211146.828505.20371961.1351184.8911998.7111300.502554.331648.504638.9669   -4.95E-012.52E-011.43E+005.49E-011.61E-01-2.44E-013.63E-023.63E-01-9.46E-023.59E-019.67E-026.82E-015.52E-02-3.06E-01-4.53E-011.16E-01-8.46E-02-1.10E+00-1.28E-01-2.79E-014.39E-02-2.60E-021.75E-013.71E-013.84E-01-9.45E-01-2.38E-015.71E-012.55E-01-6.37E-011.64E-02-1.10E-01   -1.34E-017.04E-021.31E+007.50E-01-5.32E-012.52E-01-4.30E-02-3.87E-017.68E-013.63E-017.95E-028.13E-01-1.63E-012.91E-023.57E-02-4.60E-01-3.21E-01-2.38E+001.43E-01-2.78E-01-1.15E+00-6.18E-022.17E-012.08E-01-1.42E-011.36E+006.76E-027.81E-02-4.79E-011.44E-011.16E+003.80E-01   22222222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O14896Q14116O75874P51553P41252Q9UE99P52292P24390P08779Q04695Q07666Q14165Q12765O43310O43167Q9H7D5Q9HD96O00182Q99538O95751O15468Q9UBB4Q9UFW4Q14847   K05ef6G13ef5L03ab6H11ab7I21gh1P23ab6J07ef7J14ab6E07cd7D03ab7O24ab6B04cd6O16gh1F03gh1F11gh1J03gh1I18gh7L03cd8P04ab6B04ef7G01cd8P03ef4I06cd8N17ef8P09ab7 干扰素调节因子6干扰素γ受体(IFNGR)白细胞介素18(干扰素γ诱导因子)异柠檬酸脱氢酶1(NADP+)；可溶性异柠檬酸脱氢酶3(NAD+)γ异亮氨酰-tRNA合成酶jagged 2karyopherinα2(RAG cohort 1；importinα1)KDEL(Lys-Asp-Glu-Leu)内质网蛋白质保持受体1角蛋白16(局部非表皮松解性掌跖角化病)角蛋白17含KH结构域；RNA结合；信号转导相关1KIAA0152基因产物KIAA0193基因产物KIAA0427基因产物KIAA0441基因产物KIAA1191蛋白质LAG1寿命保证同系物2(酿酒酵母)凝集素；结合半乳糖苷；可溶性；9(galectin 9)legumain亮氨酸拉链；癌中下调1白细胞免疫球蛋白样受体；亚家族B(具有TM和ITIM结构域)；成员4类似小鼠脑蛋白质E46大鼠高尔基堆积蛋白质同系物GRASP55的可能直向同源物LIM及SH3蛋白质1   495.9782616.44611525.444660.9773815.5318643.6728657.99351105.9111556.771815.5106580.31231212.816285.0232951.658482.17411398.244886.40261319.272760.6622464.5874.8344826.8073877.39971680.361664.6143   95147416104968993164601270121078611807803481000589982193079813005172749396231700758   406.9438457.8757556.9614904.897784.1063992.267696.50191670.4061411.383663.02281056.2741103.0921374.81981.6527556.09991102.5891061.3021016.572527.60811105.037970.92391120.204692.59112121.05895.1972   617.9736515.95921230.533687.2716832.7908650.6946604.77221350.1261392.342754.7055937.91591031.926669.3755979.0013542.31441160.8991291.4831044.592864.4149695.3901706.7407962.0679731.00541834.238772.769   -2.85E-01-4.29E-01-1.45E+004.53E-01-5.67E-026.24E-018.21E-025.95E-01-1.41E-01-2.99E-018.64E-01-1.37E-012.27E+004.48E-022.06E-01-3.43E-012.60E-01-3.76E-01-5.28E-011.25E+001.50E-014.38E-01-3.41E-013.36E-014.30E-01   9.39E-01-3.80E-017.71E-02-4.14E-011.40E-01-1.03E+00-5.17E-012.04E-01-3.65E-01-5.39E-021.02E+00-6.37E-012.89E-017.68E-022.88E-01-5.10E-011.12E+00-7.25E-017.79E-011.53E-01-1.67E+001.84E-01-4.94E-011.79E-021.91E-01   2222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O00158Q9HAP6P38571Q99732Q9Y4Z1O75896Q06643O95372P13473Q08397Q15046Q13312Q09160P40925P40926Q16626Q9NQG1P26572Q10469P41223Q9Y5V3P43121Q92494Q14444Q9NPE2Q92571O95204P80297Q99735   M09ef3M16gh5K08ab6I18cd5O21ef4D05cd7O07ef6J04ef7N06ab6F0gab7B17ab7D17cd3A05ab6J23ab7L01ab7J15ef3C06gh5G11ab7G15ab7L09cd4G13cd6I22ef5D11ef1H15ab7O12ef2G07ab7N11ef3H20ab7C18ef7 唯有LIM结构域4Lin-7b蛋白质；小鼠LIN-7B的可能直向同源物；哺乳动物细胞LIN-7蛋白质2脂肪酶A；溶酶体酸性；胆固醇酯酶(沃尔曼病)LPS诱导的TNF-α因子Lsm3蛋白质肺癌候选物淋巴毒素β(TNF超家族；成员3)溶血磷脂酶II溶酶体相关膜蛋白质2赖氨酰氧化酶样1赖氨酰-tRNA合成酶MAD1有丝分裂停止不足1(酵母)主要组织相容性复合物；I类；A苹果酸脱氢酶1；NAD(可溶性)苹果酸脱氢酶2；NAD(线粒体)雄性增强抗原甘露糖苷酶；βA；溶酶体样甘露糖(α1；3-)糖蛋白β1；2-N-乙酰葡糖胺转移酶甘露糖(α1；6-)糖蛋白β1；2-N-乙酰葡糖胺转移酶母性G10转录物黑素瘤抗原；家族D；1黑素瘤粘附分子膜辅蛋白(CD46；滋养细胞-淋巴细胞交叉反应性抗原)膜组分；染色体11；表面标志1间充质干细胞蛋白质DSC92中胚层特异性转录同系物(小鼠)金属蛋白酶1(pitrilysin家族)金属硫蛋白1L微粒体谷胱甘肽S-转移酶2   457.40882114.229604.0401680.38761641.224690.6061405.7368480.0562952.63931391.453900.8177807.72671524.0761144.2181525.8371253.21533.2883619.6733600.1049372.2443397.4495886.0756973.362549.4803749.8938617.581735.157589.6327527.4698   299155058789313007721040737200016305565032710788102015308003695835639527951050666932446349502686   1353.3552175.236512.8879449.47111596.905601.3296298.9254752.70791277.7732243.025539.813574.42661290.7831089.1341212.5441827.301736.627887.6535636.621575.76951674.881432.1718834.044464.81741085.26537.1735478.8153656.4441373.9779   703.09241945.862568.1283674.311511.517688.0098582.7217656.4851408.921753.531665.5485628.2311841.1061007.1571251.1581536.52689.9075625.3732606.4146503.51791008.268704.4837952.9144560.0583922.5469533.4868520.899582.747529.1741   1.56E+004.10E-02-2.36E-01-5.98E-01-3.95E-02-2.00E-01-4.41E-016.49E-014.24E-016.89E-01-7.39E-01-4.92E-01-2.40E-01-7.12E-02-3.32E-015.44E-014.66E-015.18E-018.52E-026.29E-012.08E+00-1.04E+00-2.23E-01-2.41E-015.33E-01-2.01E-01-6.19E-011.55E-01-4.96E-01   -6.16E-01-4.50E-01-4.02E-023.92E-01-3.40E-011.61E-011.36E+006.18E-011.07E+002.25E-01-6.96E-01-6.85E-018.30E-01-5.38E-01-5.88E-012.87E-015.85E-01-7.49E-01-4.29E-025.96E-011.26E+00-1.56E-011.11E-012.77E-013.14E-01-4.71E-01-1.08E+00-2.32E-013.79E-01   22222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9BXW5Q9Y6C9Q9Y3B7Q9P015Q9NX20Q9H0U6Q9NZE8Q9P0P3Q9Y317Q9Y6G3Q9BYC7Q9Y3D3Q9Y676Q9Y3D5P82921P82650Q9Y2Q9Q9NP92Q02750Q02779Q12851P49137Q9BYG3Q15014Q15773P35579Q9Y6D2P41227   D13gh8M14ef3E07ef2A12ef8M06gh2O13ef8O04ef2K18ef2M15ef2C19ef8K12gh8B12ef1C15ef8G19ef2O11gh7D07gh4A03ef8F02ef3J08ef5K09ab7N10ab8J06ef5O02gh8C17cd8F22ef4M18ef5O01ef1C21ef2G13gh1   微管相关蛋白质1轻链3α线粒体载体同系物2线粒体核糖体蛋白质L11线粒体核糖体蛋白质L15线粒体核糖体蛋白质L16线粒体核糖体蛋白质L18线粒体核糖体蛋白质L35线粒体核糖体蛋白质L37线粒体核糖体蛋白质L4线粒体核糖体蛋白质L42线粒体核糖体蛋白质L43线粒体核糖体蛋白质S16线粒体核糖体蛋白质S18B线粒体核糖体蛋白质S18C线粒体核糖体蛋白质S21线粒体核糖体蛋白质S22线粒体核糖体蛋白质S28线粒体核糖体蛋白质L30促分裂原活化蛋白激酶激酶1促分裂原活化蛋白激酶激酶激酶10促分裂原活化蛋白激酶激酶激酶激酶2促分裂原活化蛋白激酶活化的蛋白激酶2MKI67(FHA结构域)互作核仁磷蛋白MORF相关基因XmRNA；克隆：PO2ST9髓细胞性白血病因子2肌球蛋白；重链多肽9；非肌肉N-乙酰转移酶5(ARD1同系物；酿酒酵母)N-乙酰转移酶；酿酒酵母ARD1同系物   247.28171874.893401.0368553.658642.9143741.5383914.97221217.101799.6979571.7264490.5463966.7611683.2889696.3306748.082554.17841439.076669.1652615.689597.1743988.0971942.7459791.86881146.481052.442577.45851426.003531.5485800.6676   692191042176049610009108911020810665102058010801190515142053270142310201000407103010404671150708905   887.62991893.062732.113589.0617701.1442826.8816956.78881196.1431372.352689.3229619.09281006.958761.9887825.5571115.5470.6831329.749617.3223453.8702509.6637976.73911068.579307.44041262.273905.2614766.68091203.964274.9715818.2554   609.04471892.145517.9208634.2498613.4293856.3674927.27311101.3061063.499690.2211591.6118997.1495674.9976865.80211019.33513.19211395.534606.105590.1129510.095994.18041004.624502.00021144.777999.5166603.7491261.007504.9319841.2057   1.84E+001.39E-028.68E-018.94E-021.25E-011.57E-016.45E-02-2.51E-027.79E-012.70E-013.36E-015.88E-021.57E-012.46E-015.76E-01-2.36E-01-1.14E-01-1.16E-01-4.40E-01-2.29E-01-1.67E-021.81E-01-1.36E+001.39E-01-2.17E-014.09E-01-2.44E-01-9.51E-013.13E-02   1.49E+002.56E-026.88E-024.57E-01-3.74E-014.32E-01-7.77E-03-4.50E-013.49E-015.02E-014.39E-017.41E-02-2.37E-016.27E-016.75E-01-1.07E-01-2.15E-02-3.31E-011.87E-01-4.96E-014.26E-028.87E-02-9.61E-01-1.61E-01-1.60E-02-3.06E-01-3.07E-014.14E-011.76E-01   22222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q13510O43678O95167P56556O95182P51970O96000O95178O95139P17568Q9Y6M9O43677O00217P19404O76008Q9UPY4Q99742O60448Q9UNW9Q9UGL9Q9UGL6   H20ab2O09ab7E24ab7O11ab7K06ab7L04cd8J10ab8J06ab8M03ab8H02ab8P16ab8M05ab8M09ab8M07ef1A12cd6K22ef3L19gh8O07ab8P20ef3O05ab8C09gh3M09ef4   N-脂酰基神经鞘氨醇酰胺水解酶(酸性神经酰胺酶)NADH脱氢酶(泛醌)1α子复合物；2(8kD；B8)NADH脱氢酶(泛醌)1α子复合物；3(9kD；B9)NADH脱氢酶(泛醌)1α子复合物；6(14kD；B14)NADH脱氢酶(泛醌)1α子复合物；7(14.5kD；B14.5a)NADH脱氢酶(泛醌)1α子复合物；8(19kD；PGIV)NADH脱氢酶(泛醌)1β子复合物；10(22kD；PDSW)NADH脱氢酶(泛醌)1β子复合物；2(8kD；AGGG)NADH脱氢酶(泛醌)1β子复合物；6(17kD；B17)NADH脱氢酶(泛醌)1β子复合物；7(18kD；B18)NADH脱氢酶(泛醌)1β子复合物；9(22kD；B22)NADH脱氢酶(泛醌)1；子复合物未知；1(6kD；KFYI)NADH脱氢酶(泛醌)Fe-S蛋白质8(23kD)(NADH-辅酶Q还原酶)NADH脱氢酶(泛醌)黄素蛋白2(24kD)Nef相关因子1nesca蛋白质neurabin II神经元PAS结构域蛋白质1神经元螺纹蛋白质神经肿瘤学腹侧抗原2NICE-1蛋白质NICE-5蛋白质   752.15341366.7541431.6551650.612750.0893554.19951110.197925.39261392.873787.06811299.803586.50591383.4111151.224720.2744425.91491241.5441076.2591831.5921049.9591026.838912.7542   16601930177091677772814407681480567145060111304439514698624051660105013601390   677.50062137.9061506.934795.8725725.17111021.1631111.615815.2662162.279591.1924746.8017532.5511194.001356.308424.04621.93361023.077606.35891490.6241219.792381.058955.016   1028.4561810.6991570.2381120.973750.6457767.69281219.156836.32241678.472648.37031164.524573.22051234.615650.0945698.4474505.67821042.081695.85211662.0511106.982923.34231086.502   -1.51E-016.45E-017.39E-02-1.05E+00-4.87E-028.82E-011.84E-03-1.83E-016.34E-01-4.13E-01-7.99E-01-1.39E-01-2.12E-01-1.69E+00-7.64E-015.46E-01-2.79E-01-8.28E-01-2.97E-012.16E-01-1.43E+006.53E-02   1.14E+004.96E-013.08E-01-8.49E-015.03E-023.93E-013.71E-01-2.68E-018.78E-02-4.74E-011.55E-013.43E-02-2.96E-01-1.38E+004.01E-011.40E-01-5.27E-01-1.41E+00-1.38E-011.70E-034.08E-016.09E-01   2222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q92982Q9BPW8Q9NQR4Q9UF10Q9Y385Q15233Q13137Q16236P08651O95134Q15772Q9UHY1Q9UPC9Q15325O00567Q9NX24P06748P50583Q9UHM6Q9Y218Q16612P55771Q9UKJ1Q15165Q07002Q9Y3C6P30405O43924   I09ef7N19cd3B13gh4L08ef2H11ef2O02ef1A03cd6M03cd1B07ef1P10cd3N19ab2L15cd8H23ab2N22cd2D05cd6A10gh3K06gh6B01ab2N20gh8P22gh1O01cd5J21cd7N21cd8P24ab7P06ef5J07ef2F14cd5G24ab8   ninjurin 1nipsnap同系物1(线虫)Nit蛋白质2非经典泛素缀合酶1非经典泛素缀合酶1含非POU结构域；八聚物结合核结构域10蛋白质核因子(红系源性2)样2核因子I/C(CCAAT结合转录因子)velocardiofacial综合征中缺失的核定位信号核蛋白质；分化的主动脉平滑肌及随血管损伤下调标志核受体结合蛋白质核受体共活化物3核酸酶敏感性元件结合蛋白质1核仁蛋白质5A(具有KKE/D重复的56kD)核仁蛋白质家族A；成员2(H/ACA小核仁RNPs)核仁磷蛋白(核仁磷蛋白B23；numatrin)nudix(二磷酸核苷连接部分X)型基序2视蛋白4(melanopsin)optineu rinP311蛋白质配对盒基因9配对免疫球蛋白样受体α对氧磷酶2PCTAIRE蛋白激酶3肽酰脯氨酰异构酶(亲环蛋白)样1肽酰脯氨酰异构酶F(亲环蛋白F)磷酸二酯酶6D；cGMP特异性；视杆细胞；δ   458.23829.4266519.15871336.406625.63561083.363910.77251233.751726.0476465.29331473.704515.949822.77681644.614659.4335466.25391605.3681590.7631076.731014.697322.7444692.506674.1862338.5244836.5659548.5938843.1834373.1208   68952986820008081210914118062452292394811901720608625108021112001980349380450891916731925630   412.0181562.9689665.86321488.008669.8121234.216944.60791043.638659.6305536.73331157.202619.7512932.90582064.24623.2536594.84431136.972251.37681643.887912.19172231.846573.135558.3225583.7771632.7298526.6097467.6738699.1887   519.6952640.3075684.47011608.811701.19921174.503923.17121153.088669.8575508.09381184.738694.4539982.771808.771630.2325561.95471275.358684.3541305.2391302.823967.7934548.4374560.9087604.4337795.1858602.0621745.2396567.4949   -1.53E-01-5.59E-013.59E-011.55E-019.84E-021.88E-015.26E-02-2.41E-01-1.38E-012.06E-01-3.49E-012.64E-011.81E-013.28E-01-8.14E-023.51E-01-4.98E-01-2.66E+006.10E-01-1.54E-012.79E+00-2.73E-01-2.72E-017.86E-01-4.03E-01-5.90E-02-8.50E-019.06E-01   5.88E-01-6.50E-017.42E-015.83E-013.69E-011.55E-015.31E-03-6.20E-02-2.19E-011.67E-01-6.75E-018.77E-015.36E-016.25E-02-1.17E-014.22E-01-5.67E-01-2.91E+001.50E-019.66E-011.12E-01-8.67E-01-5.83E-011.40E+001.31E-014.14E-011.33E-017.56E-01   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P17858Q01813O00511P11216P00749P13797Q15102P01127Q15795O43660Q15155Q9H361Q15366P19388P52434P36954P53803Q9UQQ3Q13670Q9P0J7O60925Q9UHV9Q13519   K10ab8C17ef1N20cd3B16ab8P19ef7C13cd1E16ab8A08ef5C19ef6O18ab8G12ef3L04gh7A11cd1B15ab8F05gh6A20cd1C17cd1J08cd6B07ab8L07gh4K02ab8J15ef4J07ef6   果糖磷酸激酶；肝果糖磷酸激酶；血小板星形细胞富含的磷蛋白15磷酸化酶；糖原；脑纤溶酶原活化因子；尿激酶丝束蛋白3(T同工型)血小板活化因子乙酰水解酶；同工型Ib；γ亚基(29kD)血小板源性生长因子β多肽(猿猴肉瘤病毒性(v-sis)癌基因同系物)普列克底物蛋白同系物；Sec7及卷曲/螺旋结构域2样多效调节子1(PRL1同系物；拟南芥)pM5蛋白质多聚(A)结合蛋白质；细胞质部分3多聚(rC)结合蛋白质2聚合酶(RNA)II(DNA指导的)多肽E(25kD)聚合酶(RNA)II(DNA指导的)多肽H聚合酶(RNA)II(DNA指导的)多肽I(14.5kD)聚合酶(RNA)II(DNA指导的)多肽K(7.0kD)POP4(前体加工；酿酒酵母)同系物减数分裂后分离增强2样11钾离子通道调节因子prefoldin 1prefoldin 2prepronociceptin   950.5746573.52111330.005516.78841096.052990.1173469.9778500.6466578.295743.7263664.2511759.45661951.241552.3545949.70641603.557437.9544480.5848812.78651401.5911631.996514.4897564.2079   5256461500495344080467467474093342349114905291480182089364577917201720882464   774.727555.92362288.098988.1631051.5131393.037468.9765456.4576518.8327804.3456490.295710.95432128.585698.49651210.4111413.573528.0144551.3661532.05481192.2041860.632833.1525887.4522   750.1835591.68791704.656666.54761861.5681062.438537.6672543.5869612.22827.0995525.8869653.82861857.745593.42011211.7611613.004619.6184558.9966708.04731438.4821737.289743.3158638.4071   -2.95E-01-4.50E-027.83E-019.35E-01-5.98E-024.93E-01-3.08E-03-1.33E-01-1.57E-011.13E-01-4.38E-01-9.52E-021.26E-013.39E-013.50E-01-1.82E-012.70E-011.98E-01-6.11E-01-2.33E-011.89E-016.95E-016.53E-01   -8.56E-011.71E-011.70E-01-6.30E-021.65E+00-3.00E-015.20E-014.28E-013.55E-013.27E-01-6.51E-01-6.29E-01-3.86E-01-6.12E-026.35E-011.84E-011.03E+004.25E-01-6.07E-022.97E-017.51E-027.78E-01-2.83E-01   22222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P04156Q9UI73Q9P0T3Q02809P07237P09466Q16342O75340P35232Q9UQ80Q12796Q15188P35998P47210O00495O75831Q13200O43242   A13ab8K03ef8D14ef1P20ab7G13ab8E12ab8G22ef6I02cd8C22ef5O03cd1E05ab3P20cd2L09ab8N16cd2N03ab8N07ab8L15ab8L17ab8   朊病毒蛋白质(p27-30)(克-雅氏病；Gerstmann-Straussler-Scheinker综合征；致命性家族性失眠症)PRO0246蛋白质前凋亡半胱天冬酶衔接蛋白前胶原赖氨酸；2-酮戊二酸5-加双氧酶(赖氨酸羟化酶；埃勒斯-当洛综合征VI型)前胶原-脯氨酸；2-酮戊二酸4-加双氧酶(脯氨酸4-羟化酶)；β多肽(蛋白质二硫键异构酶；甲状腺激素结合蛋白质n55)孕激素相关子宫内膜蛋白质(胎盘蛋白质14；妊娠相关子宫内膜α2球蛋白；α子宫蛋白质)程序性细胞死亡2程序性细胞死亡6prohibitin增殖相关2G4；38kD富含脯氨酸2富含脯氨酸蛋白质BstNI亚家族3蛋白酶体(前体；macropain)26S亚基；ATP酶；2蛋白酶体(前体；macropain)26S亚基；ATP酶；5蛋白酶体(前体；macropain)26S亚基；非ATP酶；11蛋白酶体(前体；macropain)26S亚基；非ATP酶；13蛋白酶体(前体；macropain)26S亚基；非ATP酶；2蛋白酶体(前体；macropain)26S亚基；非ATP酶；3   797.9495430.4121261.463503.7557633.8309367.0939735.09611055.8862045.6931902.3871927.78997.55821010.4631037.3391043.875763.7632644.30082159.327   631535165047740662575910901810139015301290120011504986225941230   701.8217546.85992553.6521993.232575.6635708.8717490.39381356.5971600.2362003.1351475.9731404.41059.5941193563.7775506.8297331.42881637.67   710.1438504.00181820.221991.2271538.3489567.0247661.33321167.7821818.1211763.591643.6911232.0341090.4011127.919701.7628630.7237523.37021675.386   -1.85E-013.45E-011.02E+001.98E+00-1.39E-019.49E-01-5.84E-013.62E-01-3.54E-017.44E-02-3.85E-014.93E-016.85E-022.02E-01-8.89E-01-5.92E-01-9.59E-01-3.99E-01   -3.39E-013.13E-013.83E-01-7.97E-02-6.44E-017.68E-014.52E-024.70E-02-1.78E-01-4.58E-01-3.36E-013.76E-012.49E-011.53E-01-1.07E+00-2.97E-01-1.16E-01-8.13E-01   222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P55036P48556Q92530P28066O14818P49721P28062P28065P10619Q9UNN8Q15084Q9Y2B9Q13517P54619P17612P09131O60927P41236Q15435P05323   N18cd2L21ab8G07cd6J13ab8J15ab8J19ab8H18ab8B06efA07ab8F03cd6H02cd5C22cd7A09ef5F15ab8F13ab8F10gh1P02gh1C08cd1D15ab8E13ef6   蛋白酶体(前体；macropain)26S亚基；非ATP酶；4蛋白酶体(前体；macropain)26S亚基；非ATP酶；8蛋白酶体(前体；macropain)抑制剂亚基1(PI31)蛋白酶体(前体；macropain)亚基；α型；5蛋白酶体(前体；macropain)亚基；α型；7蛋白酶体(前体；macropain)亚基；β型；2蛋白酶体(前体；macropain)亚基；β型；8(多功能大蛋白酶7)蛋白酶体(前体；macropain)亚基；β型；9(多功能大蛋白酶2)β半乳糖苷酶保护性蛋白质(半乳糖唾液酸沉积症)蛋白C受体；内皮细胞(EPCR)蛋白质二硫键异构酶相关蛋白质蛋白质激酶(cAMP依赖性；催化)抑制剂γ蛋白质激酶C结合蛋白质1蛋白激酶；AMP活化的；γ1非催化亚基蛋白质激酶；cAMP依赖性；催化；α蛋白质P3蛋白磷酸酶1；调节(抑制剂)亚基11蛋白磷酸酶1；调节(抑制剂)亚基2蛋白磷酸酶1；调节亚基7蛋白质磷酸酶2(从前2A)；催化亚基；α同工型   460.80931240.2431804.777766.5891242.5171832.921797.3912771.19981539.157892.15891081.309650.9588380.9448482.8359643.0385529.00691728.646532.1136634.97591058.276   72410301570767154021109051630907702407104058757262960717606219631120   588.53461685.1161800.731775.27041139.9941617.062505.36381002.72980.3046488.5084859.0228754.6101630.5497841.1746901.5293617.06211404.955583.7663753.9046796.6526   591.04191317.421724.253769.74171308.1621853.89735.8641133.6261142.279694.2014782.4339814.4047532.9442632.0978724.5168584.24071630.486578.9436784.0242992.192   3.53E-014.42E-01-3.24E-031.62E-02-1.24E-01-1.81E-01-6.58E-013.79E-01-6.51E-01-8.69E-01-3.32E-012.13E-017.27E-018.01E-014.87E-012.22E-01-2.99E-011.34E-012.48E-01-4.10E-01   6.51E-01-2.72E-01-2.04E-011.46E-033.12E-012.04E-011.82E-011.08E+00-7.62E-01-3.46E-01-1.41E+006.73E-016.25E-012.45E-01-3.19E-021.98E-012.42E-022.23E-016.01E-018.39E-02   22222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q15257P33172O00743P38391P78324Q13332Q9HAD6O43445Q9Y6B3Q9HAN1Q9NQA4O43598O43257Q9NY06P17152Q9Y6I9P54886Q13876O14679P53611P47224Q15907P51153P35287Q9NP72P11476Q9H0U4P08886   G01ef5F01ab8F03ab8E21cd7M17cd4P21ab8C08gh6E11cd5L19ef2P19gh6C23ef4J05cd6M12cd6M07ef4H21cd4B13ef2B12ab8B03ef7K24ef5N16ab8D06ab8H04cd4D04ab8J24ef2P02ef8H22ab8L08gh7B22ab8   蛋白质磷酸酶2A；调节亚基B′(PR53)蛋白质磷酸酶4(从前X)；催化亚基蛋白质磷酸酶6；催化亚基蛋白质易位复合物β蛋白酪氨酸磷酸酶；非受体型底物1蛋白酪氨酸磷酸酶；受体型；S原钙粘蛋白16dachsous样(果蝇)PRP4前mRNA加工因子4同系物(酵母)PTD013蛋白质pumilio同系物1(果蝇)推断的酸传感性离子通道推断的c-Myc-反应性推断的细胞周期蛋白G1互作蛋白质推断的膜内在转运蛋白推断的受体蛋白质推断的分泌蛋白质吡咯啉-5-羧酸酯合成酶(谷氨酸γ半醛合成酶)利血平Q6醌氧化还原酶同系物Rab香叶基香叶基转移酶；β亚基RAB互作因子RAB11B；成员RAS癌基因家族RAB13；成员RAS癌基因家族RAB14；成员RAS癌基因家族RAB18；成员RAS癌基因家族RAB1A；成员RAS癌基因家族RAB1B；成员RAS癌基因家族RAB2；成员RAS癌基因家族   925.44581791.171998.71049.306639.23811882.284967.2552777.1081652.1251842.4925742.723473.64981118.374966.4384399.9305373.307406.7128745.299710.5753758.1496645.5902926.8757619.0867543.7425459.47861039.455526.98821483.703   905122010701050741188090654970111707626211190544650485302585116072785910309355847947676911900   1160.4371064.665738.48151428.451591.48772019.8651070.494569.37491031.7391047.18678.3813459.3831238.925569.8565591.3162742.537905.8993824.2489651.2257938.6179577.39561224.7581131.86586.1635634.6616993.586696.52922195.304   996.81161357.256936.26931175.447657.19531928.827981.1143631.8368794.91081019.233727.7123517.96661183.655693.4947547.029533.7168538.0842718.0657839.1208807.7755693.87481060.693895.2783571.2023629.3713933.4801638.09391858.384   3.26E-01-7.51E-01-4.35E-014.45E-01-1.12E-011.02E-011.46E-01-4.49E-016.62E-013.14E-01-1.31E-01-4.41E-021.48E-01-7.62E-015.64E-019.92E-011.16E+001.45E-01-1.26E-013.08E-01-1.61E-014.02E-018.70E-011.08E-014.66E-01-6.51E-024.02E-015.65E-01   -3.29E-02-5.59E-011.02E-01-9.93E-042.13E-011.57E-03-9.50E-02-5.01E-011.04E-014.71E-013.70E-023.90E-019.40E-02-8.29E-017.00E-013.79E-01-4.31E-01-3.50E-017.02E-01-6.14E-024.11E-011.53E-015.95E-011.02E-017.89E-01-4.38E-013.90E-013.54E-01   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O95716P35239P20340P43487Q9UI26P47736Q15382P52199P35238Q14644Q15404Q13283Q9NVQ9O60895P35244Q99623Q9UMQ4Q9NQC3P47804Q16576O95357Q15299Q9UMY1Q13017O43182O60274P07998   P04cd4D02ab8C07ef6D16ab8B20ef1D18ab8F17cd2B18ab2B20ab2J08ef7A10cd8H14cd5M05gh1K17cd6I22ef6D03cd7C01gh1M19cd7P03cd1P07ef6D02cd4D20ef1P05ef2M15ef6B24ab2F04gh6P21cd1   RAB3D；成员RAS癌基因家族RAB5B；成员RAS癌基因家族RAB6A；成员RAS癌基因家族RAN结合蛋白质1Ran结合蛋白质11RAP1；GTP酶活化蛋白质1脑中富含的Ras同系物2ras同系物基因家族；成员Eras同系物基因家族；成员G(rhoG)RAS p21蛋白质激活剂(GTP酶活化蛋白质)3(Ins(1；3；4；5)P4结合蛋白质)Ras抑制基因蛋白质1Ras-GTP酶活化蛋白质SH3结构域结合的蛋白质Rec8p；rad21p家族的减数分裂重组及姊妹染色单体粘着磷蛋白受体(降钙素)活性修饰蛋白质2复制蛋白质A3(14kD)雌激素受体活性阻遏物ret原癌基因(多发性内分泌腺瘤综合征及甲状腺髓样癌1；希尔施普龙病)网胃4视网膜G蛋白偶联受体成视网膜细胞瘤结合蛋白质7视黄酸诱导的3视黄酸受体β相关开放阅读框视黄酸抑制性蛋白Rho GTP酶活化蛋白质5Rho GTP酶活化蛋白质6Rho特异性鸟嘌呤核苷酸交换因子p114核糖核酸酶；RNase A家族；1(胰脏)   908.9015598.5113503.15071438.3051505.224875.86921435.587534.61691022.646615.9461543.953846.72671334.371572.8174544.02121139.283769.24841459.586403.12191539.006678.19261060.232610.5279560.4431257.146651.94841294.476   63870865511801180414219015208726231920789120051950268960258649714107139797268078065773040   556.2242393.3892416.75521786.1771273.677461.33221635.792399.05171019.472627.0592317.155571.14761325.85899.2606924.53851233.151803.931927.9776627.4176798.8744206.63521013.444586.2413514.6138895.7191366.47611592.811   701.181566.5496524.97881468.5851319.368583.63911754.23816.6152971.4616622.14751925.544735.54981286.027663.6562656.79741020.486725.1999991.1835509.14891250.347532.48371017.603641.044627.5049986.3979531.84481976.991   -7.08E-01-6.05E-01-2.72E-013.13E-01-2.41E-01-9.25E-011.88E-01-4.22E-01-4.48E-032.58E-025.86E-01-5.68E-01-9.24E-036.51E-017.65E-011.14E-016.36E-02-6.53E-016.38E-01-9.46E-01-1.71E+00-6.51E-02-5.86E-02-1.23E-01-4.89E-01-8.31E-012.99E-01   -5.10E-012.42E-013.81E-01-2.84E-01-3.52E-01-1.08E+006.10E-011.50E+00-2.29E-011.74E-023.11E-01-1.02E-01-1.56E-01-1.43E-01-1.16E-01-7.25E-01-3.53E-01-1.32E+003.02E-01-1.23E-017.14E-02-1.15E-012.51E-015.27E-01-6.41E-01-1.76E-011.23E+00   222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P04843P04844P26373P40429P39019P78317Q99942O43148O02916Q9Y580Q14621Q93062Q99497Q99584P23526O43865O14828O75326O43278O00271Q9UEW8Q13043Q9Y282P35542O75790Q9P0V3Q99519Q92185   B12cd1B14cd1D11cd1H12ef1J05cd1B04cd1F04cd2A15cd4F06ab8J10gh6H07cd7K17cd7B15cd7L17cd2A06ef1H21ab2D02cd5L05cd3I16cd2C05ef5N22ef5P15cd2F01ef2A02gh1I22cd6H17ef3C13ab8J20cd1  核糖体结合糖蛋白I核糖体结合糖蛋白II核糖体蛋白质L13核糖体蛋白质L13a核糖体蛋白质S19环指蛋白4环指蛋白5RNA(鸟嘌呤-7-)甲基转移酶RNA结合基序蛋白质4RNA结合基序蛋白质7RNA结合蛋白质(自身抗原性；与致死黄色(突变型)相关的hnRNP)多剪接的RNA结合蛋白质基因RNA结合蛋白质调节亚基S100钙结合蛋白质A13S-腺苷高半胱氨酸水解酶S-腺苷高半胱氨酸水解酶样1分泌型载体膜蛋白3sema结构域；免疫球蛋白结构域(Ig)；以及GPI膜锚着点；(semaphorin)7A丝氨酸蛋白酶抑制剂；Kunitz 1型丝氨酸蛋白酶抑制剂；Kunitz型；2丝氨酸/苏氨酸激酶39(STE20/SPS1同系物；酵母)丝氨酸/苏氨酸激酶4血清学决定的乳腺癌抗原84血清淀粉状蛋白A4；组成型7跨膜结构域蛋白质SH3结构域结合蛋白质4唾液酸酶1(溶酶体唾液酸酶)唾液酸转移酶8A(α-N-唾液酸：α-2；8-唾液酸转移酶；GD3合酶)   1493.8141574.1812091.2561928.0241794.644756.23951016.837572.6495533.7121368.8423499.5699845.09941914.86492.6196550.61811460.581661.3975795.05641295.2631379.5451230.117750.71321279.414754.5041761.38721204.005712.4593622.4236   136011701200206014806619497306287107376591400421603526460768126017401030838116013107781710680478   2248.2141880.0471924.5461091.462253.771668.80271126.187390.498430.5298558.043506.822640.45142563.974675.1457478.692466.4887481.9262943.1132641.0775876.4128841.1872756.16621907.544811.5701799.09981539.363498.7449462.7941   1700.3161540.4611739.9221694.7941841.785695.46111030.595564.3647530.87545.5838581.142714.68371958.111529.713544.258817.8431534.3923835.22761066.1621332.5521032.185781.55461448.986959.3499779.57451483.624630.4428520.9105   5.90E-012.56E-01-1.20E-01-8.21E-013.29E-01-1.77E-011.47E-01-5.52E-01-3.10E-015.97E-012.08E-02-4.00E-014.21E-014.55E-01-2.02E-01-1.65E+00-4.57E-012.46E-01-1.01E+00-6.55E-01-5.48E-011.04E-025.76E-011.05E-016.97E-023.54E-01-5.15E-01-4.28E-01   -1.37E-01-4.32E-01-7.97E-019.89E-02-2.81E-01-1.93E-01-1.00E-013.50E-012.36E-019.45E-015.61E-01-3.60E-01-4.56E-01-2.25E-011.32E-01-1.47E+00-5.24E-01-5.09E-02-3.74E-023.36E-01-2.63E-011.58E-01-1.41E-017.98E-013.16E-025.04E-01-6.70E-02-3.82E-01   2222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9Y6A9P21378O15302O76094Q9UNL2P40763Q92783Q9H723O15258O14834O43617Q04837P05455P43331P09012P08579P09234P08578Q15357P14678Q13487P35326P55854P14648P55011   C05ef8I04ef3P10ab3J02cd2J10cd2K09ef5M24cd3N01gh5A04cd7A11cd7H05ef3G11cd2E19gh1K08cd2M12cd2A03cd2A05cd2A07cd2A11cd2C23cd3P08cd1E17cd3H04cd2P19cd5L17cd1   信号肽酶12kDa信号肽酶复合物(18kD)信号识别颗粒72kD信号识别颗粒72kD信号序列受体；γ(易位子相关蛋白质γ)信号传导子及转录激活子3(急性期反应因子)信号转导衔接分子(SH3结构域及ITAM基序)1类似于大鼠核遍在的酪蛋白激酶2类似于酿酒酵母RER1类似于裂变酵母dim1+类似于酵母BET3(酿酒酵母)单链DNA结合蛋白质舍格伦综合征抗原B(自身抗原La)核内小分子核糖核蛋白D3多肽(18kD)核内小分子核糖核蛋白多肽A核内小分子核糖核蛋白多肽B″核内小分子核糖核蛋白多肽C核内小分子核糖核蛋白多肽E核内小分子核糖核蛋白多肽G核内小分子核糖核蛋白多肽B和B1核内小RNA活化复合物；多肽2；45kD富含脯氨酸的小蛋白质2Amif两个3同系物1的SMT3抑制基因(酵母)SNRPN上游阅读框溶质载体家族12(钠/钾/氯转运蛋白)；成员2   449.125630.56171040.231473.561150.724671.5038827.9851749.7661710.8499701.22921759.3481264.277850.9691916.3597548.0261502.63551054.3271901.214382.48922036.574517.5819290.6174791.74371581.907591.8676   74251581896545054510205306357531750894744126031057014501740734128068410306582270740   887.4615732.1592841.50781422.21654.744348.0347725.70171258.65933.6382903.89261443.5781034.75930.64281042.335685.6636669.98791302.7421818.557593.8471737.398648.0121839.3072962.44531670.964517.2382   692.8575626.0198899.95341286.8221085.128521.4351857.8322846.2392759.8427786.08771650.8711064.292841.92681073.82514.5708581.02791269.641819.876570.20151686.175616.6789721.2318804.1071839.36616.497   9.83E-012.16E-01-3.06E-01-5.12E-025.24E-01-9.48E-01-1.90E-017.47E-013.93E-013.66E-01-2.85E-01-2.89E-011.29E-011.86E-013.23E-014.15E-013.05E-01-6.41E-026.35E-01-2.29E-013.24E-011.53E+002.82E-017.90E-02-1.94E-01   7.24E-01-2.91E-01-3.47E-01-6.11E-01-1.35E+00-3.02E-013.01E-01-5.00E-01-1.63E-011.03E-01-7.94E-03-5.00E-01-1.93E-014.63E-01-8.22E-011.83E-014.62E-01-1.28E-019.41E-01-6.65E-014.03E-011.83E+00-2.67E-015.18E-013.23E-01   2222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  O95258O15431P04920Q01650Q07890O60749O60493Q9Y5X3Q01082P52788P17947Q14818Q15427Q15815Q01130P23152Q13503Q9P2R9Q9H6I2Q9BT81O60526Q9Y6X1P31948P21912O14521   P15cd4A21ab5L04cd1J11ef5H23cd2A19cd2A09cd4G06ef4E0gcd2M10cd2C19cd2D10ef6K11cd6M06cd2H22cd1H24cd1L22cd4C23ef2F07gh5I13gh8M03cd6A21ef4M15ef3E09gh1H04cd1 溶质载体家族25(线粒体载体；脑)；成员14溶质载体家族31(铜转运蛋白)；成员1溶质载体家族4；阴离子交换；成员2(红细胞膜蛋白带3样1)溶质载体家族7(阳离子氨基酸转运蛋白；γ+系统)；成员5sevenless之子同系物2(果蝇)分选连接蛋白2分选连接蛋白3分选连接蛋白5血影蛋白；β；非红细胞性1精胺合酶脾结节形成病毒(SFFV)前病毒性整合癌基因spi1剪接因子1剪接因子3b；亚基4；49kD剪接因子；富含精氨酸/丝氨酸10(转换基因2同系物；果蝇)剪接因子；富含精氨酸/丝氨酸2剪接因子；富含精氨酸/丝氨酸3RNA聚合酶B同系物的SRB7抑制基因(酵母)SRp25核蛋白质SRY(性别决定区Y)盒17SRY(性别决定区Y)盒7STIP1同源性及含U盒蛋白质1应力相关内质网蛋白质1；核糖体相关膜蛋白质4应力诱导的磷蛋白1(Hsp70/Hsp90组织蛋白质)琥珀酸脱氢酶复合物；亚基B；iron sulfur(Ip)琥珀酸脱氢酶复合物；亚基D；膜内在蛋白质   476.30751227.8721614.362832.6996476.9505364.93431008.916676.0975571.4909895.19941307.418547.0998441.2394738.2591553.58081547.474712.8859495.796774.5162497.0608706.60781683.36436.1143701.7228628.8405   518101015606325689311350647679854115049961255352714605745589705305381220549902505   577.83191769.0261704.1341032.106680.8529769.57821180.469688.5568387.0403770.0021646.278782.2929540.0723551.9082488.54651428.273725.0591515.095714.8666550.1706543.75592201.647517.5834751.7357672.375   523.95351336.8551624.765832.1088575.1528688.59151180.399670.591545.8922839.76931366.573609.3662530.9445614.261522.94091480.13670.5377522.8318819.674525.7297596.10191700.638500.9139785.3111601.9355   2.79E-015.27E-017.81E-023.10E-015.14E-011.08E+002.27E-012.63E-02-5.62E-01-2.17E-013.32E-015.16E-012.92E-01-4.20E-01-1.80E-01-1.16E-012.44E-025.51E-02-1.16E-011.46E-01-3.78E-013.87E-012.47E-019.93E-029.66E-02   1.20E-01-2.77E-01-5.33E-02-3.99E-012.51E-011.35E+004.22E-01-6.32E-022.49E-01-6.78E-02-1.90E-01-1.34E-014.71E-01-4.18E-01-7.18E-02-7.94E-02-3.13E-011.69E-013.24E-019.25E-02-3.93E-01-4.68E-013.32E-013.63E-01-3.18E-01   2222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P53597O95605Q16550Q15526O43539Q9UPX1O95721O43391Q15833Q92804Q9Y490O94797Q13311Q16650P51864P55061Q15569O60636O60637O95857Q99614Q13118Q15583Q9H3N1O43396P04216P12956   I09gh1P15cd5K01cd2K07cd2P02cd1D23cd7O09cd5H09cd2J04cd2O20cd3B04cd2H20ef7C05cd6F08cd6O04ef7O19cd2P21cd2F08cd5F06cd5F13ef3M03cd3L05cd2A16cd2N03gh7O17cd5B02cd2K10ef6   琥珀酸辅酶A连接酶；GDP形成；α亚基SUMO-1活化酶亚基2Ty 4同系物1抑制子(酿酒酵母)surfeit 1SWI/SNF相关；基质结合；肌动蛋白依赖性染色质调节子；亚家族e；成员1突触孔蛋白突触小体相关蛋白质；29kD多配体聚糖结合蛋白质(syntenin)突触融合蛋白结合蛋白质2TAF15 RNA聚合酶II；TATA盒结合蛋白质(TBP)相关因子；68kD踝蛋白1Tara样蛋白质Tax1(人T细胞白血病病毒I型)结合蛋白质1T-盒；脑；1畸胎癌源性生长因子3；假基因睾丸增强基因转录物(BAX抑制剂1)睾丸特异性激酶1tetraspan 2tetraspan 3tetraspan N ET-6蛋白质tetratrico肽重复结构域1TGFB可诱导性早期生长反应TGFB诱导因子(TALE家族同源异形盒)包含硫氧还蛋白结构域硫氧还蛋白样；32kDThy-1细胞表面抗原甲状腺自身抗原70kD(Ku抗原)   704.4006776.4199813.5735468.36141047.14683.4973830.7721625.6962661.0175873.55841342.238899.0807899.99791407.3092037.2121540.968837.6269468.16641025.362702.1579706.3536445.9691885.9409.63331821.595169.80641172.56   49149914405221280536103064055660511704481190175015901330796702742676891601129042617102981490   553.293433.2742991.3588583.80971212.614421.1841686.6755379.1899840.69511063.7782365.625496.1404926.23141777.8891447.461972.323708.1178375.3225545.9662359.1921635.5379679.29311140.439686.79971548.5964157.3671395.803   582.7447569.41631081.744524.70261178.519546.8885849.1506548.1569686.0183847.49361625.187614.37771004.5051645.1841690.2821615.143780.661515.2157770.9441578.9636744.2616575.47321105.268507.4281693.1791541.6091353.001   -3.48E-01-8.42E-012.85E-013.18E-012.12E-01-6.98E-01-2.75E-01-7.23E-013.47E-012.84E-018.18E-01-8.58E-014.15E-023.37E-01-4.93E-013.56E-01-2.42E-01-3.19E-01-9.09E-01-9.67E-01-1.52E-016.07E-013.64E-017.46E-01-2.34E-014.61E+002.51E-01   -5.22E-01-6.39E-018.24E-011.56E-012.85E-01-3.51E-013.10E-013.17E-02-2.49E-01-5.30E-01-2.01E-01-1.01E+004.00E-013.15E-01-3.61E-01-2.10E-01-7.31E-025.85E-01-4.68E-01-5.58E-023.35E-014.31E-015.42E-015.60E-02-9.18E-028.10E-013.46E-01   222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P16035Q9H2X8Q13077Q9NZ34Q15369Q15906P50616Q13595P37802Q9Y5Z9Q99595O60830O14925Q9Y5J9Q15629Q99442Q99805Q9Y2B0P49755Q03519Q9NWF9Q15656Q92734Q12815P09493P49411P05217P23258   P11ef7I08gh8L11cd2P08gh4D18ef6P11ef6H08cd5N04ef7F05cd3D01cd8K10cd6A09cd6I24cd6E08cd8G18ef3C10cd2A18cd5C20ef3J05ef4F03gh4B07cd1P02gh2O07ef7J17cd7A21ef7O02cd1M11cd3F03gh6K03cd3   金属蛋白酶组织抑制剂2TLH29蛋白质前体TNF受体相关因子1TPA调节的基因座转录延伸因子B(SIII)；多肽1(15kD；elongin C)转录因子样1ERBB2转导蛋白；1转换基因2α(htra-2α)transgelin 2变移上皮反应蛋白质线粒体内膜易位酶17同系物A(酵母)线粒体内膜易位酶17同系物B(酵母)线粒体内膜易位酶23同系物(酵母)线粒体内膜易位酶8同系物B(酵母)易位链相关膜蛋白易位蛋白质1跨膜9超家族成员2跨膜蛋白质4跨膜运输蛋白质跨膜；前列腺雄激素诱导RNA转运蛋白2；ATP结合盒；亚家族B(MDR/TAP)TRIAD3蛋白质TRK融合基因TRK融合基因trophinin相关蛋白质(tastin)原肌球蛋白1(α)Tu翻译延伸因子；线粒体微管蛋白；β；2微管蛋白；γ1   360.2533710.24471265.0541074.319771.5598436.5561888.8059247.44371986.7161324.284450.65781646.564745.81021641.3771003.031526.87831023.368681.38571311.2031287.98851.2148665.97721878.2541450.307821.5601988.1694525.85721203.6861733.971   35410001270109011005108746122240875665159081315501060772126013204698415734441640181011004295557051220   913.13511386.102756.4011284.44693.1767878.9083518.1816698.3791173.4341126.793448.51611992.925653.43011653.524624.44991065.397957.2801985.8397700.7243662.4165680.8519688.66461858.3071609.067722.86441004.982476.4592920.18312149.365   542.45171033.6481097.4041148.575854.8396608.5936760.3803519.2191798.4731108.824521.26021744.175737.4511615.991897.0752788.0011081.028995.6424827.066930.4505701.534599.40531792.5011624.429879.96807.373519.255942.80881702.331   1.34E+009.65E-01-7.42E-012.58E-01-1.55E-011.01E+00-7.78E-011.50E+00-7.60E-01-2.33E-01-6.87E-032.75E-01-1.91E-011.06E-02-6.84E-011.02E+00-9.63E-025.33E-01-9.04E-01-9.59E-01-3.22E-014.83E-02-1.54E-021.50E-01-1.85E-012.43E-02-1.42E-01-3.87E-013.10E-01   -2.54E-025.00E-016.49E-031.69E-025.11E-012.25E-01-2.40E-021.31E+001.70E-01-5.97E-015.60E-01-4.77E-021.25E-01-7.98E-028.48E-025.51E-013.03E-019.54E-01-1.48E+00-6.15E-01-5.72E-01-5.86E-01-1.95E-013.23E-014.15E-01-1.20E+007.90E-02-7.73E-01-5.03E-01   22222222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  Q9UBN6Q13829O00496Q99816P16422Q9NP84Q9UJ47P31946P35214P27348O60704Q9Y4Z0P14927Q9UI02P31930P22695P07919P47985Q9NZ09Q9UNP0Q9UHP3P22314Q13404   A16ef6L22ef4K21cd3G04cd4C03ab7K03ef2O09cd8K21ef6J19ef4G15cd7J01cd3G09cd8G06cd4P18ef7A22cd3A24cd3E08cd4E06cd4N17ef1F09gh6L21cd8O07cd3O23cd3   肿瘤坏死因子受体超家族；成员10d；具有截短死亡结构域的诱饵肿瘤坏死因子；α诱导蛋白质1(内皮细胞)肿瘤抑制亚转移候选物3肿瘤易感基因101肿瘤相关钙信号转导蛋白1I型跨膜蛋白质Fn14I型跨膜受体(捕获相关蛋白质)酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；β多肽酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；γ多肽酪氨酸3-单加氧酶/色氨酸5-单加氧酶活化蛋白质；θ多肽酪氨酰蛋白磺基转移酶2U6 snRNA相关Sm样蛋白质泛醇-细胞色素C还原酶结合蛋白质泛醇-细胞色素C还原酶复合物(7.2kD)泛醇-细胞色素C还原酶核心蛋白质I泛醇-细胞色素C还原酶核心蛋白质II泛醇-细胞色素C还原酶铰链蛋白质泛醇-细胞色素C还原酶；Rieskeiron-sulfur多肽1泛素相关蛋白质泛素特异性蛋白酶15泛素特异性蛋白酶25泛素活化酶E1(A1S9T和BN75温度敏感性互补)泛素缀合酶E2变体1   470.7412849.276628.3509723.81331448.512691.89792.98731220.989881.01312196.334658.3761837.5087995.1237953.6884846.6396468.59361328.5321519.7631588.177525.3364554.06571857.2381073.414   7517925547667914988199559891540299689817146084963618101270182049272416401210   531.524552.7776800.8751627.1295373.663560.2824809.9056724.9898682.53271104.855686.1339914.9547954.30851546.568686.9864581.7911005.3781127.5751392.592597.7817561.58171863.3161128.962   584.4772731.2933661.0848705.4904870.9367583.2792807.3703966.9847850.99641615.078547.7036813.8478922.14751320.75794.0747562.06331382.3911306.0861598.619538.3523613.08451788.5031138.559   1.75E-01-6.20E-013.50E-01-2.07E-01-1.95E+00-3.04E-013.05E-02-7.52E-01-3.68E-01-9.91E-015.96E-021.28E-01-6.04E-026.97E-01-3.01E-013.12E-01-4.02E-01-4.31E-01-1.90E-011.86E-011.94E-024.71E-037.28E-02   6.74E-01-1.01E-01-1.82E-018.08E-02-8.73E-01-4.75E-014.69E-02-3.55E-011.67E-01-5.08E-01-1.14E+00-2.81E-01-2.85E-016.16E-013.33E-034.40E-014.49E-01-2.58E-011.93E-01-9.48E-023.85E-01-1.75E-011.77E-01   22222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P51669P47986O14933Q16781Q93068Q15386Q9UBK9O60512P78383Q16851Q9NZ45Q9NZ32Q9NZ29Q15853Q92528P15692P50552O60763Q15836Q9UEU0P14921P18206P00540P01106P21796Q15765   D05cd4O11cd3H14cd4D07cd4A02cd3I10gh1I15cd4E11ab3P20cd5I24cd4L02gh3L20gh4L16gh4C02cd3D02ef7M04ef7C08cd3H16cd3A15ef5O22cd6E24ef5C14cd3G08ef5E18ef5C16cd3C12cd3   泛素缀合酶E2D 2(UBC4/5同系物；酵母)泛素缀合酶E2D 3(UBC4/5同系物；酵母)泛素缀合酶E2L 6泛素缀合酶E2N(UBC13同系物；酵母)泛素样1(sentrin)泛素蛋白质异构肽连接酶(E3)遍在表达的转录物UDP-Gal：βGlcNAcβ1；4-半乳糖基转移酶；多肽3UDP-半乳糖转运蛋白相关UDP-葡萄糖焦磷酸化酶2非特征性造血干/祖细胞蛋白质MDS029非特征性下丘脑蛋白质HARP11非特征性下丘脑蛋白质HT007上游转录因子2；c-fos互作尿苷单磷酸激酶血管内皮生长因子血管舒张剂刺激的磷蛋白囊泡停靠蛋白p115小泡相关膜蛋白质3(cellubrevin)小泡相关可溶性NSF附着蛋白质受体(v-SNARE ；酿酒酵母VTI1同系物)v-ets成红细胞病毒E26癌基因同系物1(鸟类)粘着斑蛋白v-mos莫洛尼小鼠肉瘤病毒癌基因同系物v-myc髓细胞瘤病病毒癌基因同系物(鸟类)电压依从性阴离子通道1von Hippel-Lindau结合蛋白质1   1266.25616.3689717.4244923.65371376.087531.8659936.2619436.76341570.1351324.08652.06851035.575659.53601.6839560.3976460.9257468.4573639.538804.2648468.6024913.893580.33151115.145537.8131483.8969689.743   1300520893816153063010606101700126067012509926356855396485431370697765857728601510705   1173.73567.7317596.6415533.73891294.307628.24541384.764542.392180.1171318.78696.56921354.2311118.776698.0128623.5243857.3853392.5569745.48061060.211698.3534291.1538865.7505663.6747405.1047584.201891.2621   1247.427567.8765735.6835757.9641399.48596.86861125.743529.58391816.9631302.468672.98951214.412923.518644.9023623.0076619.202502.9122642.76241076.578621.1953656.6528767.5496835.5051514.7639525.9036762.0788   -1.09E-01-1.19E-01-2.66E-01-7.91E-01-8.84E-022.40E-015.65E-013.12E-014.74E-01-5.79E-039.52E-023.87E-017.62E-012.14E-011.54E-018.95E-01-2.55E-012.21E-013.99E-015.76E-01-1.65E+005.77E-01-7.49E-01-4.09E-012.72E-013.70E-01   4.05E-02-2.47E-013.16E-01-1.78E-011.51E-012.45E-011.74E-014.81E-011.15E-01-6.64E-023.98E-022.75E-015.89E-017.78E-022.90E-012.27E-014.67E-01-2.35E-017.63E-015.72E-01-2.57E-015.62E-01-6.16E-011.61E-017.47E-023.20E-02   22222222222222222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等
  P10398P11233Q9Y6W5Q9UPY6O75083O76071Q9HCN4Q9UM05Q9UQR1Q14119Q9NW07P20694   D01ab4A19ef6A22gh1L06cd6D15cd5A24cd5H11gh6N17ef3P06gh1G21ef5F06gh2D04ef6   v-raf小鼠肉瘤3611病毒癌基因同系物1v-ral猿猴白血病病毒癌基因同系物A(ras相关)WAS蛋白质家族；成员2WAS蛋白质家族；成员3WD重复结构域1WD40蛋白质Ciao1XPA结合蛋白质1；推断的ATP(GTP)-结合蛋白质酵母Sec31p同系物锌指蛋白148(pHZ-52)锌指蛋白161锌指蛋白358锌指蛋白9(细胞逆转录病毒核酸结合蛋白质)   1061.812848.70991283.0771503.584892.4425609.88211199.211887.447513.86391199.558402.83421042.65   6391060163012109778981070159073717605751010   532.21531081.4281493.1452151.643963.3448730.5311507.32771542.778563.76251197.34684.7069856.5924   744.4583995.80441468.5141623.108944.1492746.1814923.97531672.59604.92011387.253554.3431969.9823   -9.96E-013.50E-012.19E-015.17E-011.10E-012.60E-01-1.24E+00-2.91E-011.34E-01-2.67E-037.65E-01-2.84E-01   -7.32E-013.17E-013.45E-01-3.09E-011.30E-015.58E-01-1.71E-01-2.50E-015.21E-015.57E-015.15E-01-4.49E-02   222222222222   恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等恒中等

Claims (63)

1.扩增哺乳动物腺泡细胞的方法，包含在一定条件下在含有细胞培养基和细胞附着表面的细胞培养系统中培养所述细胞，在该条件下，所述腺泡细胞经过3-4倍扩增并转分化为显示腺泡细胞和肝细胞特征的改变的细胞表型(IP细胞)。
2.权利要求1的方法，其中所述具有改变表型的细胞表达细胞角蛋白18(CK18)、CK8、CK19、CK7、HNF1、α-1抗胰蛋白酶、π谷胱甘肽s转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β，并如果表达的话也只表达少量碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶。
3.权利要求1的方法，其中所述培养基在适于维持上皮细胞的基本培养基中包含胰岛素、转铁蛋白、硒和表皮生长因子(EGF)。
4.权利要求1的方法，其中所述培养基包含血清。
5.权利要求4的方法，其中所述培养基包含不超过15％的血清。
6.权利要求1的方法，其中所述培养基无血清。
7.权利要求1的方法，其中所述细胞培养基包含促进腺泡细胞生长扩增并转分化为IP细胞的有效量的至少一种可溶性活性因子。
8.权利要求7的方法，其中所述培养基包含有效量的至少一种可溶性活性因子，其选自热失活牛血清白蛋白(BSA)和可溶性活性因子肝细胞生长因子(HGF)、胰岛素样生长因子-1(IGF-1)、转化生长因子α(TGF-α)、betacellulin、胃泌素I和促乳素。
9.权利要求7的方法，其中所述培养基包含有效量的至少一种可溶性活性因子，其选自HGF、betacellulin和促乳素。
10.权利要求1的方法，其中所述细胞附着表面包含一种或多种细胞外基质分子。
11.权利要求10的方法，其中所述细胞附着表面包含一种或多种细胞外基质分子，其选自胶原I、胶原VI、胶原IV、玻连蛋白和纤连蛋白。
12.权利要求1的方法，其中细胞按103-105细胞/cm2的密度接种。
13.权利要求1的方法，其中细胞培养4-8天。
14.权利要求1的方法，其中腺泡细胞是人腺泡细胞。
15.权利要求1的方法，其中腺泡细胞经过从淀粉酶+腺泡表型至淀粉酶+/CK19+混合性腺泡/肝特异性表型的转分化。
16.包含适用于维持哺乳动物上皮细胞的基本培养基的培养基，其包括胰岛素、转铁蛋白、硒和EGF，其中在所述培养基中于合适条件下培养人腺泡细胞4-8天，使该细胞扩增3-4倍并转分化为显示腺泡和肝细胞特征的改变的细胞表型。
17.权利要求16的培养基，其中该基本培养基包含DMEM、Hams F12、MEM、M-199或RPMI，或其组合。
18.权利要求17的培养基，其中该基本培养基包含4mM谷氨酰胺以及DMEM与Hams 12的1∶1混合物。
19.权利要求16的培养基，其另外包含血清。
20.权利要求19的培养基，其另外包含不超过15％的血清。
21.权利要求16的培养基，其无血清。
22.权利要求16的细胞培养基，其包含约0.1-10μg/ml胰岛素、约0.5-10μg/ml转铁蛋白、约0.25-5.0ng/ml硒以及约1-20ng/l EGF。
23.权利要求16的细胞培养基，其另外包含促进腺泡细胞扩增并转分化为IP细胞的有效量的至少一种可溶性活性因子。
24.权利要求16的方法，其另外包含有效量的至少一种因子，选自热失活BSA和可溶性活性因子白蛋白、HGF、IGF-1、TGF-α、betacellulin、胃泌素I和促乳素。
25.权利要求24的细胞培养基，其中BSA浓度为0.1-2％，HGF浓度为1-20ng/ml，IGF-1浓度为0.5-50ng/ml，TGF-α浓度为1-10ng/ml，betacellulin浓度为0.0005-0.1μg/ml，胃泌素I浓度为1-100pg/ml以及促乳素浓度为1-10ng/ml。
26.权利要求24的细胞培养基，其包含有效量的至少一种可溶性活性因子，选自HGF、betacellulin和促乳素。
27.一种细胞培养系统，其包含权利要求16的细胞培养基和细胞附着表面。
28.权利要求27的细胞培养系统，其中该细胞附着表面包含一种成分，其选自胶原I、胶原VI、胶原IV、玻连蛋白和纤连蛋白。
29.具有包含腺泡及肝相关标志的表型的分离的哺乳动物细胞。
30.权利要求29的分离的细胞，其表达至少一种选自下列的标志：CK18、CK8、CK19、CK7、HNF1、α-1抗胰蛋白酶、π谷胱甘肽s转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β；并表达少量或不表达下列标志：碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶。
31.权利要求29的分离的细胞，其表达CK18、CK8、CK19、CK7、HNF1、α-1抗胰蛋白酶、π谷胱甘肽s转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β。
32.权利要求29的分离的细胞，其来源于胰腺腺泡细胞的原代培养物。
33.权利要求29的分离的细胞，其是人细胞。
34.权利要求29的分离的细胞，其具有表6所示离体8天后的表达特征。
35.利用权利要求1方法制备的分离的细胞。
36.适用于扩增哺乳动物腺泡细胞的试剂盒，其包含
a)适于培养哺乳动物上皮细胞的基本培养基，
b)胶原I包被培养基层，和独立包装的
c)无血清培养基添加物，其包含一种或多种成分，选自BSA、HGF、EGF、TGFA、betacellulin、胃泌素I和IGF-1。
37.权利要求36的试剂盒，其中无血清培养基添加物包含适当比例的成分，通过加入预定量的基本培养基，来制备包含0.1-2％BSA、1-20ng/ml HGF、1-20ng/ml EGF、1-10ng/ml TGFA、0.0005-0.10μg/mlbetacellulin、1.0-100pg/mL胃泌素I以及0.5-50ng/mL IGF1的培养基。
38.权利要求36的试剂盒，其中细胞培养基层位于适合细胞培养的培养瓶、瓶子、培养皿、板或孔的表面，或者是支架的一部分。
39.体外将表达腺泡细胞及肝相关基因标志的IP细胞转化为胰岛素生成细胞的方法，其包含将所述IP细胞在包含有效量的至少一种分化促进因子的细胞培养基中培养，该分化促进因子选自活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚基、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-I)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、促乳素、SonicHedgehog、P物质、TGF-α、Trolox(α生育酚衍生物)和VEGF，以致将IP细胞转化为胰岛素产生细胞。
40.权利要求39的方法，其中该IP细胞来源自胰腺腺泡细胞的培养物。
41.权利要求40的方法，其中该细胞是人细胞。
42.权利要求39的方法，其另外包括使所述细胞接触包被有一种或多种细胞外基质分子的基层。
43.权利要求42的方法，其中该细胞外基质分子为胶原I、胶原VI、胶原IV、玻连蛋白和纤连蛋白。
44.权利要求42的方法，其中该基层位于培养瓶、瓶子、培养皿、板、孔或滚瓶的表面，或者是支架的一部分。
45.权利要求39的方法，其中该培养基无血清。
46.权利要求39的方法，其中该培养基含血清。
47.权利要求46的方法，其中该培养基包含BSA、胰岛素、转铁蛋白、硒和表皮生长因子(EGF)。
48.权利要求39的方法，其中细胞按5×103-20×105细胞/cm2的密度接种于基层。
49.利用权利要求39方法产生的分离的胰岛素产生细胞。
50.通过体外分化哺乳动物腺泡细胞制备的胰岛素产生细胞，其中所述胰岛素产生细胞具有表6所示离体16天后的表达特征。
51.包含至少一种活性因子的无血清培养基，该活性因子选自活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚基、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-I)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、促乳素、Sonic Hedgehog、P物质、TGF-α、Trolox(α生育酚衍生物)和VEGF，其中所述培养基促进IP细胞分化为胰岛素产生细胞。
52.包含DMEM和Hams F12的1∶1混合物外加表2所列成分的无血清培养基。
53.适用于将IP细胞分化为胰岛素产生细胞的试剂盒，其包含
a)适于培养哺乳动物上皮细胞的基本培养基，
b)胶原I包被培养基层，和独立包装的
c)无血清培养基添加物，其包含BSA、活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚基、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-I)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、促乳素、SonicHedgehog、P物质、TGF-α、Trolox(α生育酚衍生物)或VEGF，或这些成分两种或多种的组合，按适量以达到此处表1所示完全培养基中的终浓度。
54.权利要求53的试剂盒，其中细胞培养基层包含于适合细胞培养的培养瓶、瓶子、培养皿、板或孔的表面。
55.通过体外培养和处理胰腺腺泡细胞而获得胰岛素产生细胞的方法，包括以下步骤
i)在一定条件下在包含培养基和细胞附着表面的细胞培养系统中培养胰腺腺泡细胞，在该条件下，所述腺泡细胞经过3-4倍扩增并转分化为表达细胞角蛋白18(CK18)、CK8、CK19、CK7、HNF1、α-1抗胰蛋白酶、π谷胱甘肽s转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β；并如果表达的话也只表达少量碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶的部分分化的IP细胞；以及
ii)在包含细胞培养基和基层的细胞培养系统中培养所述IP细胞，所述培养基包含有效量的至少一种分化促进因子，选自活化素A、酸性FGF、碱性FGF、C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚基、地塞米松、胃泌素释放肽、胰高血糖素样肽-1(GLP-I)、葡萄糖、IGF1、IGF2、胰岛素、层粘连蛋白、LIF、Met-脑啡肽、PDGFAA+PDGFBB、促乳素、Sonic Hedgehog、P物质、TGF-α、Trolox(α生育酚衍生物)和VEGF；以致将IP细胞转化为胰岛素产生细胞。
56.权利要求55的方法，其中所述胰岛素产生细胞响应接触葡萄糖而释放c-肽和/或胰岛素。
57.权利要求55的方法，其中步骤i)的培养基包含HGF受体活化剂和EGF受体活化剂。
58.权利要求55的方法，其中步骤ii)的培养基包含有效量的至少一种可溶性活性因子，选自C-钠尿肽(CNP)、降钙素基因相关肽、霍乱毒素B亚基、地塞米松、胃泌素释放肽、层粘连蛋白、Met-脑啡肽、PDGFAA+PDGFBB、Sonic Hedgehog和P物质。
59.获得胰岛素产生细胞的方法，所述方法包括在两相培养系统中培养原代胰腺细胞，其第一相中，细胞在培养基中在包含有效量的至少一种ECM的表面上培养4-10天，培养基包含选自HGF、TGFα、EGF、IGF1、betacellulin、促乳素和胃泌素1的至少一种活性可溶性因子；其第二相中，细胞在培养基中在包含至少一种ECM的表面上培养3-14天，培养基包含有效量的至少一种分化促进因子，选自活化素A、CGRP α、C-钠尿肽(CNP)、霍乱毒素B亚基、地塞米松、aFGF、胰高血糖素样肽-1(GLP-I)、葡萄糖、胰岛素、LIF、PDGFAA、PDGFBB、TGF-α、促乳素、Trolox(维生素E)、胃泌素释放肽(GRP)、IGF-1、IGF-2、层粘连蛋白、Met-脑啡肽、Sonic Hedgehog、P物质、bFGF和VEGF，以获得胰岛素生成细胞。
60.来源于腺体上皮细胞的胰岛素产生细胞的原代培养物，其表达选自细胞角蛋白18(CK18)、CK8、CK19、CK7、HNF1、α-1抗胰蛋白酶、π谷胱甘肽s转移酶(π-GST)、肝特异性bHLH转录因子、Thy-1、C/EBP-α和C/EBP-β的至少一种标志；并如果表达的话也只表达少量选自碳酸酐酶、囊性纤维化跨膜传导调节蛋白(CFTR)、弹性蛋白酶和淀粉酶标志，所述胰岛素产生细胞具有形成包含胰岛素原和/或胰岛素和/或c-肽的三维细胞团簇的特征。
61.权利要求60的培养物，其中该腺体上皮细胞是胰腺细胞。
62.权利要求60的培养物，其中该培养物响应葡萄糖的激发而释放胰岛素和/或c-肽。
63.权利要求60的培养物，其中该腺体上皮细胞是人细胞。
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104593399A (zh) * 2014-12-22 2015-05-06 广西大学 一种转基因胰岛素的合成工艺
CN106680510A (zh) * 2016-12-27 2017-05-17 中南大学湘雅医院 Myoferlin及其特异性抗体在制备检测鼻咽癌试剂盒中的应用
CN107034177A (zh) * 2017-06-02 2017-08-11 北京市农林科学院 一种牛卵泡膜细胞体外培养调节剂及其应用
CN112956453A (zh) * 2021-04-07 2021-06-15 华北理工大学 一种黑腹果蝇胰岛素抵抗糖尿病模型的建立方法
CN114250194A (zh) * 2021-11-30 2022-03-29 四川大学华西医院 一种急性胰腺炎细胞模型的构建方法和用途

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162131A0 (en) * 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
US20060122104A1 (en) * 2002-05-28 2006-06-08 Presnell Sharon C Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells
US7604991B2 (en) * 2003-06-20 2009-10-20 Vrije Universiteit Brussel Method of generating islet beta-cells from exocrine pancreatic cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
JP5148873B2 (ja) 2003-06-27 2013-02-20 エチコン、インコーポレイテッド 臍帯組織由来の分娩後細胞、及びその作成及び使用方法
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
AU2003903896A0 (en) 2003-07-28 2003-08-07 Queensland University Of Technology Skin regeneration system
AU2004260815B2 (en) * 2003-07-28 2010-05-20 Queensland University Of Technology Skin regeneration system
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7510876B2 (en) * 2003-12-23 2009-03-31 Cythera, Inc. Definitive endoderm
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US8647873B2 (en) * 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) * 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
WO2005118781A1 (ja) * 2004-06-03 2005-12-15 Kyoto University インスリン分泌細胞の誘導
AU2005272681B2 (en) * 2004-08-13 2009-11-19 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
JP2008520235A (ja) * 2004-11-22 2008-06-19 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
WO2006071802A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
JP5584875B2 (ja) * 2005-04-13 2014-09-10 国立大学法人 千葉大学 成体膵由来膵幹細胞の製造方法
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
SI1888123T1 (sl) 2005-06-08 2013-04-30 Janssen Biotech, Inc. Celična terapija za okularno degeneracijo
US9487755B2 (en) * 2005-10-06 2016-11-08 David Moscatello Cell culture media, kits and methods of use
JP5404047B2 (ja) 2005-10-27 2014-01-29 ヴィアサイト，インコーポレイテッド Ｐｄｘ１発現背側及び腹側前腸内胚葉
PL1788077T3 (pl) * 2005-11-18 2017-03-31 Lifescan, Inc. Sposób tworzenia klastrów komórek
ES2642844T3 (es) 2005-12-16 2017-11-20 DePuy Synthes Products, Inc. Composiciones y métodos para inhibir una respuesta inmune adversa en el trasplante de histocompatibilidad que no coinciden
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
DK2650359T3 (da) * 2006-03-02 2022-06-13 Viacyte Inc Endokrine prekursorceller, pancreatiske hormon-udtrykkende celler og fremstillingsfremgangsmåder
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US20090286317A1 (en) * 2006-09-14 2009-11-19 Probiogen Ag Modular culture system for maintenance, differentiation and proliferation of cells
US20100323442A1 (en) * 2006-10-17 2010-12-23 Emmanuel Edward Baetge Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
WO2008124169A2 (en) * 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Islet cells composition and methods
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
RU2473685C2 (ru) 2007-07-31 2013-01-27 Лайфскен, Инк. Дифференцировка человеческих эмбриональных стволовых клеток
ES2648128T3 (es) 2007-07-31 2017-12-28 Lifescan, Inc. Diferenciación de células madre pluripotentes usando células alimentadoras humanas
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US7846974B2 (en) * 2007-10-24 2010-12-07 National University Corporation Gunma University Method of lowering blood glucose and method of treating diabetes and obesity
KR20090051695A (ko) * 2007-11-19 2009-05-22 배용석 췌도 주변세포를 인슐린을 분비할 수 있는 세포로 분화시키는 방법
CN101878298B (zh) 2007-11-27 2017-08-15 生命扫描有限公司 人胚胎干细胞的分化
CN105886459A (zh) 2008-02-21 2016-08-24 詹森生物科技公司 用于细胞粘附、培养和分离的方法、表面改性培养板和组合物
US8728812B2 (en) * 2008-04-22 2014-05-20 President And Fellows Of Harvard College Compositions and methods for promoting the generation of PDX1+ pancreatic cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
KR101829310B1 (ko) 2008-06-30 2018-02-14 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
EA020490B1 (ru) * 2008-08-30 2014-11-28 Тарганта Терапьютикс Корп. Способ лечения бактериальной инфекции
JP5307489B2 (ja) * 2008-09-19 2013-10-02 株式会社クラレ 三次元細胞構造体の作製方法
ES2634445T3 (es) 2008-10-31 2017-09-27 Janssen Biotech, Inc. Diferenciación de las células madre embrionarias humanas con el linaje endocrino pancreático
EP2350265B1 (en) 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
CN105349517B (zh) 2008-11-14 2021-05-04 维赛特公司 源于人多能干细胞的胰腺细胞的包封
US20100124781A1 (en) 2008-11-20 2010-05-20 Shelley Nelson Pluripotent Stem Cell Culture on Micro-Carriers
JP5719305B2 (ja) 2008-11-20 2015-05-13 ヤンセン バイオテツク，インコーポレーテツド 平面支持体上での細胞付着及び培養のための方法及び組成物
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
IL196820A0 (en) 2009-02-01 2009-11-18 Yissum Res Dev Co Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells
AU2010229651B2 (en) 2009-03-26 2014-05-08 Advanced Technologies And Regenerative Medicine, Llc Human umbilical cord tissue cells as therapy for Alzheimer' s disease
WO2010135639A2 (en) * 2009-05-21 2010-11-25 Joslin Diabetes Center, Inc. Compositions and methods for promoting beta cell maturity
CN102597219B (zh) 2009-07-20 2015-08-19 詹森生物科技公司 人胚胎干细胞的分化
CN102482640B (zh) 2009-07-20 2015-03-11 詹森生物科技公司 人胚胎干细胞的分化
RU2579278C2 (ru) 2009-07-20 2016-04-10 Янссен Байотек, Инк. Популяция панкреатических эндокринных клеток-предшественников для снижения концентрации глюкозы в крови и способ дифференцировки панкреатических эндодермальных клеток
CA2784415C (en) 2009-12-23 2019-06-18 Jean Xu Differentiation of human embryonic stem cells
EP2516626B1 (en) 2009-12-23 2017-05-10 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN102791851B (zh) 2010-03-01 2017-07-14 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
EP3498825A1 (en) 2010-05-12 2019-06-19 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN101880648B (zh) * 2010-06-25 2012-10-03 广东药学院 一种胰腺腺泡细胞的原代培养方法
BR112013004514A2 (pt) 2010-08-31 2016-06-07 Janssen Biotech Inc diferenciação das células-tronco embrionárias humanas
SG10201506855RA (en) 2010-08-31 2015-10-29 Janssen Biotech Inc Differentiation of human embryonic stem cells
CA2809305C (en) 2010-08-31 2019-06-11 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
JP5922147B2 (ja) * 2010-12-15 2016-05-24 カディマステム リミテッド 多能性幹細胞に由来するインスリン産生細胞
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
CN103958665A (zh) * 2011-11-11 2014-07-30 基本药品有限责任公司 包含血清替代物和不稳定因子的试剂盒
RU2705001C2 (ru) 2011-12-22 2019-11-01 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
CN104837987B (zh) 2011-12-23 2018-10-02 德普伊新特斯产品公司 人脐带组织来源的细胞的检测
EP2823037A4 (en) 2012-03-07 2015-09-16 Janssen Biotech Inc DEFINED MEDIA FOR THE EXPANSION AND CARE OF PLURIPOTENTAL STEM CELLS
AU2013271581B2 (en) 2012-06-08 2018-08-09 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
CA2896750A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
WO2014105543A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
BR112015015701A2 (pt) 2012-12-31 2017-07-11 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células pancreáticas endócrinas com o uso de reguladores hb9
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
EP3008170A4 (en) 2013-06-11 2016-11-09 Harvard College SC-CELLS AND COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2014207578A2 (en) 2013-06-13 2014-12-31 Orgenesis Ltd. Cell populations, methods of transdifferention and methods of use thereof
DK3143127T3 (da) 2014-05-16 2021-09-13 Janssen Biotech Inc Anvendelse af små molekyler til at forstærke mafa-ekspression i endokrine pankreasceller
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
EP4374863A2 (en) 2014-12-18 2024-05-29 President and Fellows of Harvard College Methods for generating stem cell-derived beta cells and uses thereof
US10253298B2 (en) 2014-12-18 2019-04-09 President And Fellows Of Harvard College Methods for generating stem cell-derived beta cells and methods of use thereof
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
SG11201907030VA (en) * 2017-01-31 2019-08-27 Univ Osaka Method for controlling differentiation of pluripotent stem cells
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018207179A1 (en) 2017-05-08 2018-11-15 Orgenesis Ltd. Transdifferentiated cell populations and methods of use thereof
JP2020537522A (ja) 2017-10-13 2020-12-24 イーエムベーアー−インスティテュート フュール モレクラレ バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 体細胞の増強された再プログラミング
AU2018370029A1 (en) 2017-11-15 2020-07-02 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
AU2019320072A1 (en) 2018-08-10 2021-02-25 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
CN110579457B (zh) * 2019-09-20 2021-11-02 郑州大学第一附属医院 波形蛋白特异响应性荧光探针及其制备方法和应用
CN113341152B (zh) * 2021-04-27 2022-04-26 华南农业大学 Rps9蛋白在食蟹猴超数排卵良好应答预测中的应用
US11735303B2 (en) 2021-06-22 2023-08-22 David Haase Apparatus and method for determining a composition of a replacement therapy treatment
WO2023123299A1 (en) * 2021-12-31 2023-07-06 Beijing Theraxyte Bioscience Co., Ltd. Compositions and methods for culturing stem cells
CN115282065B (zh) * 2022-08-11 2024-03-15 顾帅 一种含间充质干细胞外泌体的冻干粉及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4332893A (en) * 1980-06-13 1982-06-01 Rosenberg Ralph A Process for the production of an insulin-producing cell line of pancreatic beta cells
DE3801236A1 (de) * 1988-01-18 1989-07-27 Boehringer Mannheim Gmbh Pentosansulfat-medium
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US5834308A (en) * 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
US5935852A (en) * 1997-07-03 1999-08-10 Genetics Institute, Inc. DNA molecules encoding mammalian cerberus-like proteins
US7056734B1 (en) * 1998-08-10 2006-06-06 The United States Of America As Represented By The Department Of Health And Human Services, Nih Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US6946293B1 (en) * 1999-02-10 2005-09-20 Es Cell International Pte Ltd. Progenitor cells, methods and uses related thereto
WO2000047720A2 (en) * 1999-02-10 2000-08-17 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6362201B1 (en) * 1999-03-02 2002-03-26 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
US6967019B2 (en) * 1999-04-06 2005-11-22 The Regents Of The University Of California Production of pancreatic islet cells and delivery of insulin
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
JP2003513624A (ja) * 1999-10-29 2003-04-15 マクギル・ユニヴァーシティ 脱分化した細胞を調製するための培地
US6382201B1 (en) * 1999-11-17 2002-05-07 Mathew A. McPherson Bow vibration damper
US6610535B1 (en) * 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
AU3350201A (en) * 2000-02-18 2001-08-27 Inst Medical W & E Hall Pancreatic islet cell growth factors
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
US6642003B2 (en) * 2001-08-02 2003-11-04 Cedars-Sinai Medical Center Human glucose-dependent insulin-secreting cell line
US7524492B2 (en) * 2001-08-31 2009-04-28 Joslin Diabetes Center, Inc. Insulin related transcription factor and uses thereof
CA2463914A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
US20060122104A1 (en) * 2002-05-28 2006-06-08 Presnell Sharon C Methods for in vitro expansion and transdifferentiation of human pancreatic acinar cells into insulin-producing cells

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104593399A (zh) * 2014-12-22 2015-05-06 广西大学 一种转基因胰岛素的合成工艺
CN106680510A (zh) * 2016-12-27 2017-05-17 中南大学湘雅医院 Myoferlin及其特异性抗体在制备检测鼻咽癌试剂盒中的应用
CN106680510B (zh) * 2016-12-27 2018-02-27 中南大学湘雅医院 Myoferlin及其特异性抗体在制备检测鼻咽癌试剂盒中的应用
CN107034177A (zh) * 2017-06-02 2017-08-11 北京市农林科学院 一种牛卵泡膜细胞体外培养调节剂及其应用
CN107034177B (zh) * 2017-06-02 2021-01-19 北京市农林科学院 一种牛卵泡膜细胞体外培养调节剂及其应用
CN112956453A (zh) * 2021-04-07 2021-06-15 华北理工大学 一种黑腹果蝇胰岛素抵抗糖尿病模型的建立方法
CN114250194A (zh) * 2021-11-30 2022-03-29 四川大学华西医院 一种急性胰腺炎细胞模型的构建方法和用途

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