CN1806047A - 新型腈水合酶 - Google Patents

新型腈水合酶 Download PDF

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Publication number
CN1806047A
CN1806047A CNA2004800161703A CN200480016170A CN1806047A CN 1806047 A CN1806047 A CN 1806047A CN A2004800161703 A CNA2004800161703 A CN A2004800161703A CN 200480016170 A CN200480016170 A CN 200480016170A CN 1806047 A CN1806047 A CN 1806047A
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CN
China
Prior art keywords
subunit
dna
activity
nitrile hydratase
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800161703A
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English (en)
Chinese (zh)
Inventor
古家加夫留
玉木彰
长泽伸一郎
铃木绫乃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Original Assignee
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Kogyo KK filed Critical Asahi Kasei Kogyo KK
Publication of CN1806047A publication Critical patent/CN1806047A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01084—Nitrile hydratase (4.2.1.84)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2004800161703A 2003-06-10 2004-06-10 新型腈水合酶 Pending CN1806047A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003164773 2003-06-10
JP164773/2003 2003-06-10

Publications (1)

Publication Number Publication Date
CN1806047A true CN1806047A (zh) 2006-07-19

Family

ID=33508825

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800161703A Pending CN1806047A (zh) 2003-06-10 2004-06-10 新型腈水合酶

Country Status (6)

Country Link
JP (1) JP4108095B2 (ja)
KR (1) KR100806991B1 (ja)
CN (1) CN1806047A (ja)
AU (1) AU2004245849B2 (ja)
TW (1) TW200504211A (ja)
WO (1) WO2004108942A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459962A (zh) * 2014-06-06 2017-02-22 三菱丽阳株式会社 改良型腈水合酶
CN107075494A (zh) * 2014-09-30 2017-08-18 巴斯夫欧洲公司 制备具有较少丙烯酸的酰胺化合物的手段和方法
CN111334495A (zh) * 2020-03-12 2020-06-26 东莞市东阳光生物合成药有限公司 制备右旋酰胺酮洛芬的方法
CN113444714A (zh) * 2021-07-29 2021-09-28 浙江大学杭州国际科创中心 一种β亚基突变的腈水合酶突变体及其应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200634151A (en) * 2004-12-09 2006-10-01 Asahi Chemical Ind Transformant expressing nitrile hydratase
JP2007181404A (ja) * 2005-12-29 2007-07-19 Institute Of Physical & Chemical Research イソニトリル加水分解酵素、およびアミンの製造方法
WO2008004473A1 (fr) * 2006-07-06 2008-01-10 University Of Tsukuba Nouveau complexe de protéines, procédé de maturation de nitrile hydratase à faible poids moléculaire de type au cobalt utilisant le complexe de protéines, nitrile hydratase correspondante et procédé l'utilisant
JP5080787B2 (ja) * 2006-11-15 2012-11-21 達彦 小林 タンパク質改変方法、ニトリルヒドラターゼ成熟化方法、成熟化ニトリルヒドラターゼ生産方法、成熟化ニトリルヒドラターゼを用いたアミド化合物生産方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153415A (en) * 1998-04-29 2000-11-28 Board Of Trustees Operating Michigan State University Method for producing amide compounds using a nitrile hydratase from a thermophilic bacillus

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459962A (zh) * 2014-06-06 2017-02-22 三菱丽阳株式会社 改良型腈水合酶
CN107075494A (zh) * 2014-09-30 2017-08-18 巴斯夫欧洲公司 制备具有较少丙烯酸的酰胺化合物的手段和方法
CN107075494B (zh) * 2014-09-30 2021-11-23 巴斯夫欧洲公司 制备具有较少丙烯酸的酰胺化合物的手段和方法
CN111334495A (zh) * 2020-03-12 2020-06-26 东莞市东阳光生物合成药有限公司 制备右旋酰胺酮洛芬的方法
CN111334495B (zh) * 2020-03-12 2022-04-29 宜昌东阳光生化制药有限公司 制备右旋酰胺酮洛芬的方法
CN113444714A (zh) * 2021-07-29 2021-09-28 浙江大学杭州国际科创中心 一种β亚基突变的腈水合酶突变体及其应用

Also Published As

Publication number Publication date
KR100806991B1 (ko) 2008-02-25
WO2004108942A1 (ja) 2004-12-16
AU2004245849B2 (en) 2008-10-09
TWI321151B (ja) 2010-03-01
JPWO2004108942A1 (ja) 2006-07-20
TW200504211A (en) 2005-02-01
KR20060016115A (ko) 2006-02-21
AU2004245849A1 (en) 2004-12-16
JP4108095B2 (ja) 2008-06-25

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