CN1802167A - 融合蛋白质 - Google Patents

融合蛋白质 Download PDF

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Publication number
CN1802167A
CN1802167A CNA2004800159578A CN200480015957A CN1802167A CN 1802167 A CN1802167 A CN 1802167A CN A2004800159578 A CNA2004800159578 A CN A2004800159578A CN 200480015957 A CN200480015957 A CN 200480015957A CN 1802167 A CN1802167 A CN 1802167A
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CN
China
Prior art keywords
gly
ser
val
pro
lys
Prior art date
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Pending
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CNA2004800159578A
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English (en)
Chinese (zh)
Inventor
W·格莱斯纳
R·L·小米利肯
Y·甸
S－H·R·奇昂
A·M·维克
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Eli Lilly and Co
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Eli Lilly and Co
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Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1802167A publication Critical patent/CN1802167A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2004800159578A 2003-06-12 2004-06-10 融合蛋白质 Pending CN1802167A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47788003P 2003-06-12 2003-06-12
US60/477,880 2003-06-12
US57090804P 2004-05-13 2004-05-13
US60/570,908 2004-05-13
PCT/US2004/016611 WO2004110472A2 (en) 2003-06-12 2004-06-10 Fusion proteins

Publications (1)

Publication Number Publication Date
CN1802167A true CN1802167A (zh) 2006-07-12

Family

ID=33555478

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800159578A Pending CN1802167A (zh) 2003-06-12 2004-06-10 融合蛋白质

Country Status (17)

Country Link
US (1) US20070253966A1 (cg-RX-API-DMAC7.html)
EP (1) EP1641483B1 (cg-RX-API-DMAC7.html)
JP (1) JP2007505643A (cg-RX-API-DMAC7.html)
CN (1) CN1802167A (cg-RX-API-DMAC7.html)
AT (1) ATE385806T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004247042A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0411112A (cg-RX-API-DMAC7.html)
CA (1) CA2526169A1 (cg-RX-API-DMAC7.html)
CY (1) CY1107248T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004011770T2 (cg-RX-API-DMAC7.html)
DK (1) DK1641483T3 (cg-RX-API-DMAC7.html)
ES (1) ES2298785T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA05013564A (cg-RX-API-DMAC7.html)
PL (1) PL1641483T3 (cg-RX-API-DMAC7.html)
PT (1) PT1641483E (cg-RX-API-DMAC7.html)
SI (1) SI1641483T1 (cg-RX-API-DMAC7.html)
WO (1) WO2004110472A2 (cg-RX-API-DMAC7.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397569A (zh) * 2015-08-01 2017-02-15 深圳红石科创生物科技发展有限公司 一种治疗代谢疾病的突变细胞因子融合蛋白
CN106573053A (zh) * 2014-06-23 2017-04-19 詹森生物科技公司 干扰素α和ω抗体拮抗剂
CN108570109A (zh) * 2017-03-14 2018-09-25 广东东阳光药业有限公司 包含免疫球蛋白Fc部分的双靶点融合蛋白
CN109206523A (zh) * 2018-08-27 2019-01-15 沣潮医药科技（上海）有限公司 Tigit免疫粘附素、制备方法及用途
CN109748972A (zh) * 2019-01-31 2019-05-14 泉州师范学院 一种细胞珠蛋白-人源乳铁蛋白肽融合蛋白、基因及应用
WO2024067401A1 (zh) 2022-09-26 2024-04-04 中美华世通生物医药科技(武汉)股份有限公司 包含Fc-高级脂肪酸链的超长效平台

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US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
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Cited By (8)

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Publication number Priority date Publication date Assignee Title
CN106573053A (zh) * 2014-06-23 2017-04-19 詹森生物科技公司 干扰素α和ω抗体拮抗剂
CN106573053B (zh) * 2014-06-23 2021-12-28 詹森生物科技公司 干扰素α和ω抗体拮抗剂
CN106397569A (zh) * 2015-08-01 2017-02-15 深圳红石科创生物科技发展有限公司 一种治疗代谢疾病的突变细胞因子融合蛋白
CN106397569B (zh) * 2015-08-01 2020-09-01 深圳红石科创生物科技发展有限公司 一种治疗代谢疾病的突变细胞因子融合蛋白
CN108570109A (zh) * 2017-03-14 2018-09-25 广东东阳光药业有限公司 包含免疫球蛋白Fc部分的双靶点融合蛋白
CN109206523A (zh) * 2018-08-27 2019-01-15 沣潮医药科技（上海）有限公司 Tigit免疫粘附素、制备方法及用途
CN109748972A (zh) * 2019-01-31 2019-05-14 泉州师范学院 一种细胞珠蛋白-人源乳铁蛋白肽融合蛋白、基因及应用
WO2024067401A1 (zh) 2022-09-26 2024-04-04 中美华世通生物医药科技(武汉)股份有限公司 包含Fc-高级脂肪酸链的超长效平台

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ATE385806T1 (de) 2008-03-15
EP1641483A2 (en) 2006-04-05
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PL1641483T3 (pl) 2008-07-31
DE602004011770T2 (de) 2009-02-05
EP1641483B1 (en) 2008-02-13
SI1641483T1 (sl) 2008-08-31
WO2004110472A3 (en) 2005-02-03
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PT1641483E (pt) 2008-04-29
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