CN1694960B - 酿酒酵母erg4突变体在表达哺乳动物来源的葡萄糖转运蛋白中的用途 - Google Patents

酿酒酵母erg4突变体在表达哺乳动物来源的葡萄糖转运蛋白中的用途 Download PDF

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Publication number
CN1694960B
CN1694960B CN038251485A CN03825148A CN1694960B CN 1694960 B CN1694960 B CN 1694960B CN 038251485 A CN038251485 A CN 038251485A CN 03825148 A CN03825148 A CN 03825148A CN 1694960 B CN1694960 B CN 1694960B
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polynucleotide
yeast cell
protein
yeast
glut4v85m
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CN038251485A
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Chinese (zh)
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CN1694960A (zh
Inventor
G·米勒
S·德卢盖伊
D·福斯
E·博尔斯
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN038251485A 2002-09-14 2003-09-04 酿酒酵母erg4突变体在表达哺乳动物来源的葡萄糖转运蛋白中的用途 Expired - Fee Related CN1694960B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10242763.1 2002-09-14
DE10242763A DE10242763A1 (de) 2002-09-14 2002-09-14 Verwendung von Saccharomyces cerevisiae erg4-Mutanten zur Expression von Glukosetransportern aus Säugetieren
PCT/EP2003/009812 WO2004026907A2 (de) 2002-09-14 2003-09-04 Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren

Publications (2)

Publication Number Publication Date
CN1694960A CN1694960A (zh) 2005-11-09
CN1694960B true CN1694960B (zh) 2010-05-12

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CN038251485A Expired - Fee Related CN1694960B (zh) 2002-09-14 2003-09-04 酿酒酵母erg4突变体在表达哺乳动物来源的葡萄糖转运蛋白中的用途

Country Status (15)

Country Link
EP (1) EP1539958A2 (de)
JP (1) JP4520854B2 (de)
KR (1) KR101233998B1 (de)
CN (1) CN1694960B (de)
AU (1) AU2003264257B2 (de)
BR (1) BR0314115A (de)
CA (1) CA2498636C (de)
DE (1) DE10242763A1 (de)
HK (1) HK1084401A1 (de)
IL (2) IL167321A (de)
MX (1) MXPA05002816A (de)
NO (1) NO20051795L (de)
RU (1) RU2345136C2 (de)
WO (1) WO2004026907A2 (de)
ZA (1) ZA200501871B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102899328A (zh) * 2012-09-28 2013-01-30 南京农业大学 山羊葡萄糖转运载体4基因及其重组表达载体和应用
CN110408616B (zh) * 2019-07-09 2021-06-15 中南民族大学 GLUT4基因敲除的sgRNA、A549细胞系及其构建方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942398A (en) * 1998-02-26 1999-08-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glutx and uses thereof
AU5477500A (en) * 1999-06-09 2000-12-28 General Hospital Corporation, The Method of measuring plasma membrane targeting of glut4
DE10106718A1 (de) * 2001-02-14 2002-09-05 Aventis Pharma Gmbh Hefestamm von Saccharomyces cerevisiae mit funktioneller Expression eines Glut-Transporters

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Buse John B,et al..Human GLUT4/muscle-fat glucose-transporter gene: Characterization and genetic variation..Diabetes41.1992,1436-1445. *
US－6346374－B1 2002.02.12
Wieczorke R,et al..Concurrent knock-out of at least 20 transporter genes is required to block up take of hexose in Saccharomyces cerevisiae..FEBS Letters464.1999,123-128. *
WO－0075188－A1 2000.12.14
WO－02064784－A2 2002.08.22

Also Published As

Publication number Publication date
EP1539958A2 (de) 2005-06-15
WO2004026907A2 (de) 2004-04-01
ZA200501871B (en) 2005-10-26
CN1694960A (zh) 2005-11-09
AU2003264257B2 (en) 2010-05-20
KR20050056206A (ko) 2005-06-14
BR0314115A (pt) 2005-07-12
RU2005110955A (ru) 2006-01-20
KR101233998B1 (ko) 2013-02-18
CA2498636A1 (en) 2004-04-01
CA2498636C (en) 2012-04-17
WO2004026907A3 (de) 2004-11-11
MXPA05002816A (es) 2005-05-27
IL197621A0 (en) 2011-08-01
JP4520854B2 (ja) 2010-08-11
DE10242763A1 (de) 2004-03-18
RU2345136C2 (ru) 2009-01-27
JP2006517088A (ja) 2006-07-20
IL197621A (en) 2014-01-30
IL167321A (en) 2013-11-28
HK1084401A1 (en) 2006-07-28
NO20051795L (no) 2005-06-08
AU2003264257A1 (en) 2004-04-08

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