WO2004026907A3 - Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren - Google Patents

Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren Download PDF

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Publication number
WO2004026907A3
WO2004026907A3 PCT/EP2003/009812 EP0309812W WO2004026907A3 WO 2004026907 A3 WO2004026907 A3 WO 2004026907A3 EP 0309812 W EP0309812 W EP 0309812W WO 2004026907 A3 WO2004026907 A3 WO 2004026907A3
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WIPO (PCT)
Prior art keywords
erg4
mutants
mammals
expression
saccharomyces cerevisiae
Prior art date
Application number
PCT/EP2003/009812
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English (en)
French (fr)
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WO2004026907A2 (de
Inventor
Guenter Mueller
Silke Dlugai
Doerthe Voss
Eckhard Boles
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0314115-2A priority Critical patent/BR0314115A/pt
Priority to CA2498636A priority patent/CA2498636C/en
Priority to KR1020057004292A priority patent/KR101233998B1/ko
Priority to JP2004536979A priority patent/JP4520854B2/ja
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority to EP03797264A priority patent/EP1539958A2/de
Priority to AU2003264257A priority patent/AU2003264257B2/en
Priority to CN038251485A priority patent/CN1694960B/zh
Priority to MXPA05002816A priority patent/MXPA05002816A/es
Publication of WO2004026907A2 publication Critical patent/WO2004026907A2/de
Publication of WO2004026907A3 publication Critical patent/WO2004026907A3/de
Priority to ZA2005/01871A priority patent/ZA200501871B/en
Priority to IL167321A priority patent/IL167321A/en
Priority to NO20051795A priority patent/NO20051795L/no
Priority to HK06104586.6A priority patent/HK1084401A1/xx
Priority to IL197621A priority patent/IL197621A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die Erfindung bezieht sich auf Hefestämme, in denen ein humaner GLUT4 Transporter oder ein humaner GLUT1 Transporter funktional zur Expression gebracht werden kann sowie auf bestimmte GLUT4 Transportproteine, die in Hefestämmen besonders einfach funktional exprimiert werden können.
PCT/EP2003/009812 2002-09-14 2003-09-04 Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren WO2004026907A2 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
AU2003264257A AU2003264257B2 (en) 2002-09-14 2003-09-04 Use of Saccharomyces cerevisiae ERG4 mutants for the expression of glucose transporters from mammals
KR1020057004292A KR101233998B1 (ko) 2002-09-14 2003-09-04 포유동물 기원의 글루코즈 수송체의 발현을 위한 사카로마이세스 세레비지애 ｅｒｇ4 돌연변이체의 용도
JP2004536979A JP4520854B2 (ja) 2002-09-14 2003-09-04 哺乳動物由来のグルコーストランスポーターの発現のための、サッカロミセス・セレビジエＥｒｇ４突然変異体の使用
MXPA05002816A MXPA05002816A (es) 2002-09-14 2003-09-04 Uso de mutantes erg4 de saccharomyces cerevisiae para la expresion de transportadores de glucosa de mamiferos.
EP03797264A EP1539958A2 (de) 2002-09-14 2003-09-04 Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren
CA2498636A CA2498636C (en) 2002-09-14 2003-09-04 Use of saccharomyces cerevisiae erg4 mutants for the expression of glucose transporters from mammals
CN038251485A CN1694960B (zh) 2002-09-14 2003-09-04 酿酒酵母erg4突变体在表达哺乳动物来源的葡萄糖转运蛋白中的用途
BR0314115-2A BR0314115A (pt) 2002-09-14 2003-09-04 Utilização de mutantes erg4 de saccharomyces cerevisiae para expressão de transportadores de glicose de mamìferos
ZA2005/01871A ZA200501871B (en) 2002-09-14 2005-03-04 Use of saccharomyces cerevisiae erg4 mutants for the expression of glucose transporters from mammals
IL167321A IL167321A (en) 2002-09-14 2005-03-08 Polynucleotide containing DNA sequence that encode glucose 4, a yeast cell containing this polynucleotide and a process for making this yeast cell
NO20051795A NO20051795L (no) 2002-09-14 2005-04-12 Anvendelse av saccharomyces cerevisiae ERG4-mutanter for ekspresjon av glukosetransportorer fra pattedyr
HK06104586.6A HK1084401A1 (en) 2002-09-14 2006-04-18 Use of saccharomyces cerevisiae erg4 mutants for the expression of glucose transporters from mammals
IL197621A IL197621A (en) 2002-09-14 2009-03-16 Sacromisase Serug 4 mutants and methods for identifying substances that inhibit the activity of 1fgy gene-compatible proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10242763.1 2002-09-14
DE10242763A DE10242763A1 (de) 2002-09-14 2002-09-14 Verwendung von Saccharomyces cerevisiae erg4-Mutanten zur Expression von Glukosetransportern aus Säugetieren

Publications (2)

Publication Number Publication Date
WO2004026907A2 WO2004026907A2 (de) 2004-04-01
WO2004026907A3 true WO2004026907A3 (de) 2004-11-11

Family

ID=31724774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/009812 WO2004026907A2 (de) 2002-09-14 2003-09-04 Verwendung von saccharomyces cerevisiae erg4-mutanten zur expression von glukosetransportern aus säugetieren

Country Status (15)

Country Link
EP (1) EP1539958A2 (de)
JP (1) JP4520854B2 (de)
KR (1) KR101233998B1 (de)
CN (1) CN1694960B (de)
AU (1) AU2003264257B2 (de)
BR (1) BR0314115A (de)
CA (1) CA2498636C (de)
DE (1) DE10242763A1 (de)
HK (1) HK1084401A1 (de)
IL (2) IL167321A (de)
MX (1) MXPA05002816A (de)
NO (1) NO20051795L (de)
RU (1) RU2345136C2 (de)
WO (1) WO2004026907A2 (de)
ZA (1) ZA200501871B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102899328A (zh) * 2012-09-28 2013-01-30 南京农业大学 山羊葡萄糖转运载体4基因及其重组表达载体和应用
CN110408616B (zh) * 2019-07-09 2021-06-15 中南民族大学 GLUT4基因敲除的sgRNA、A549细胞系及其构建方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075188A1 (en) * 1999-06-09 2000-12-14 Whitehead Institute For Biomedical Research Method of measuring plasma membrane targeting of glut4
US6346374B1 (en) * 1998-02-26 2002-02-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding GLUTX and uses thereof
WO2002064784A2 (de) * 2001-02-14 2002-08-22 Aventis Pharma Deutschland Gmbh Hefestamm von saccharomyces cerevisiae mit funktioneller expression eines glut-transporters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346374B1 (en) * 1998-02-26 2002-02-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding GLUTX and uses thereof
WO2000075188A1 (en) * 1999-06-09 2000-12-14 Whitehead Institute For Biomedical Research Method of measuring plasma membrane targeting of glut4
WO2002064784A2 (de) * 2001-02-14 2002-08-22 Aventis Pharma Deutschland Gmbh Hefestamm von saccharomyces cerevisiae mit funktioneller expression eines glut-transporters

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUSE JOHN B ET AL: "Human GLUT4/muscle-fat glucose-transporter gene: Characterization and genetic variation", DIABETES, vol. 41, no. 11, 1992, pages 1436 - 1445, XP009025818, ISSN: 0012-1797 *
WIECZORKE R ET AL: "Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 464, no. 3, 31 December 1999 (1999-12-31), pages 123 - 128, XP004260734, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
EP1539958A2 (de) 2005-06-15
WO2004026907A2 (de) 2004-04-01
ZA200501871B (en) 2005-10-26
CN1694960A (zh) 2005-11-09
AU2003264257B2 (en) 2010-05-20
KR20050056206A (ko) 2005-06-14
BR0314115A (pt) 2005-07-12
RU2005110955A (ru) 2006-01-20
KR101233998B1 (ko) 2013-02-18
CA2498636A1 (en) 2004-04-01
CN1694960B (zh) 2010-05-12
CA2498636C (en) 2012-04-17
MXPA05002816A (es) 2005-05-27
IL197621A0 (en) 2011-08-01
JP4520854B2 (ja) 2010-08-11
DE10242763A1 (de) 2004-03-18
RU2345136C2 (ru) 2009-01-27
JP2006517088A (ja) 2006-07-20
IL197621A (en) 2014-01-30
IL167321A (en) 2013-11-28
HK1084401A1 (en) 2006-07-28
NO20051795L (no) 2005-06-08
AU2003264257A1 (en) 2004-04-08

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