CN1691950A - 通过施加超高静水压力的移植用生物体组织的处理方法 - Google Patents
通过施加超高静水压力的移植用生物体组织的处理方法 Download PDFInfo
- Publication number
- CN1691950A CN1691950A CNA038214849A CN03821484A CN1691950A CN 1691950 A CN1691950 A CN 1691950A CN A038214849 A CNA038214849 A CN A038214849A CN 03821484 A CN03821484 A CN 03821484A CN 1691950 A CN1691950 A CN 1691950A
- Authority
- CN
- China
- Prior art keywords
- tissue
- processing
- hydrostatic pressure
- cell
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002706 hydrostatic effect Effects 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims description 12
- 238000002054 transplantation Methods 0.000 title abstract 2
- 210000001519 tissue Anatomy 0.000 claims abstract description 37
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 210000002808 connective tissue Anatomy 0.000 claims abstract description 3
- 238000012545 processing Methods 0.000 claims description 17
- 239000004094 surface-active agent Substances 0.000 claims description 11
- 210000003709 heart valve Anatomy 0.000 claims description 7
- 210000002216 heart Anatomy 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 238000003672 processing method Methods 0.000 claims description 5
- 210000004204 blood vessel Anatomy 0.000 claims description 4
- 210000004872 soft tissue Anatomy 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 210000000845 cartilage Anatomy 0.000 claims description 2
- 210000000515 tooth Anatomy 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 2
- 210000001691 amnion Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 210000001951 dura mater Anatomy 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000000815 hypotonic solution Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 18
- 241000700605 Viruses Species 0.000 description 5
- 238000007710 freezing Methods 0.000 description 5
- 230000008014 freezing Effects 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 210000003850 cellular structure Anatomy 0.000 description 4
- 230000008595 infiltration Effects 0.000 description 4
- 238000001764 infiltration Methods 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000009795 derivation Methods 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 210000001765 aortic valve Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 210000003102 pulmonary valve Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000007204 Brain death Diseases 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- BXKDSDJJOVIHMX-UHFFFAOYSA-N edrophonium chloride Chemical compound [Cl-].CC[N+](C)(C)C1=CC=CC(O)=C1 BXKDSDJJOVIHMX-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002264470A JP4092397B2 (ja) | 2002-09-10 | 2002-09-10 | 超高静水圧印加による移植用生体組織の処理方法 |
JP264470/2002 | 2002-09-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1691950A true CN1691950A (zh) | 2005-11-02 |
CN1330316C CN1330316C (zh) | 2007-08-08 |
Family
ID=31986527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038214849A Expired - Lifetime CN1330316C (zh) | 2002-09-10 | 2003-09-09 | 通过施加超高静水压力的移植用生物体组织的处理方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060110720A1 (zh) |
EP (1) | EP1541157B1 (zh) |
JP (1) | JP4092397B2 (zh) |
KR (1) | KR100869685B1 (zh) |
CN (1) | CN1330316C (zh) |
AU (1) | AU2003262030B2 (zh) |
CA (1) | CA2507498C (zh) |
WO (1) | WO2004024170A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102470149A (zh) * | 2009-08-18 | 2012-05-23 | 生命细胞公司 | 用于处理组织的方法 |
CN105944142A (zh) * | 2016-05-09 | 2016-09-21 | 拜欧迪赛尔(北京)生物科技有限公司 | 一种新型的脱细胞肌腱或韧带支架的制备方法 |
CN107249656A (zh) * | 2015-02-27 | 2017-10-13 | Adeka株式会社 | 脱细胞化组织 |
CN110740762A (zh) * | 2017-05-30 | 2020-01-31 | 株式会社Adeka | 移植用脱细胞化材料制造方法及由包含该材料的生物相容性材料组成的移植片组成物 |
CN115554472A (zh) * | 2022-09-22 | 2023-01-03 | 舩本诚一 | 一种用于移植的生物组织处理方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5050197B2 (ja) * | 2006-07-31 | 2012-10-17 | 財団法人ヒューマンサイエンス振興財団 | 生物由来スキャフォールドの作製方法 |
US8486139B2 (en) * | 2007-03-09 | 2013-07-16 | National University Corporation Tokyo Medical And Dental University | Method of preparing decellularized soft tissue, graft and culture material |
KR101269618B1 (ko) * | 2011-04-12 | 2013-06-05 | 한스바이오메드 주식회사 | 포유류의 연골조직에서 유래한 생체이식재 |
WO2012141454A2 (en) * | 2011-04-12 | 2012-10-18 | Hans Biomed. Cor. | Graft materials derived from mammalian cartilage |
JPWO2014065017A1 (ja) | 2012-10-26 | 2016-09-08 | 株式会社ジェイ・エム・エス | 人工血管、および、人工血管の製造方法 |
CA2911592C (en) | 2013-05-07 | 2021-10-26 | The Chemo-Sero-Therapeutic Research Institute | Hybrid gel comprising particulate decellularized tissue |
KR102240373B1 (ko) | 2013-05-07 | 2021-04-13 | 고쿠리츠 다이가쿠호우징 도쿄이카시카다이가쿠 | 입자상 탈세포화 조직의 제조방법 |
JP6433901B2 (ja) | 2013-08-14 | 2018-12-05 | 国立研究開発法人理化学研究所 | 光透過性に優れた生物材料を調製するための組成物およびその利用 |
JP6271298B2 (ja) * | 2014-02-28 | 2018-01-31 | 国立大学法人 東京医科歯科大学 | 脱細胞組織の製造方法 |
NL2012797B1 (en) * | 2014-05-09 | 2016-02-24 | Tournois Dynamic Innovations B V | Bone material process. |
JP6793113B2 (ja) | 2015-03-12 | 2020-12-02 | Kmバイオロジクス株式会社 | 脱細胞化組織を用いた癒着防止材及び代用生体膜 |
JP7472142B2 (ja) | 2019-08-01 | 2024-04-22 | Kmバイオロジクス株式会社 | 生体適合性高分子を用いた組織の線維化抑制剤 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5333626A (en) * | 1991-12-31 | 1994-08-02 | Cryolife, Inc. | Preparation of bone for transplantation |
US6121041A (en) * | 1996-07-31 | 2000-09-19 | St. Jude Medical, Inc. | Use of microorganisms for decellularizing bioprosthetic tissue |
US6482584B1 (en) * | 1998-11-13 | 2002-11-19 | Regeneration Technologies, Inc. | Cyclic implant perfusion cleaning and passivation process |
WO1999041981A1 (en) * | 1998-02-20 | 1999-08-26 | Lifecell Corporation | Method of processing and preserving collagen based tissues |
AU5574101A (en) * | 2000-04-28 | 2001-11-12 | Univ Emory | Decellularized vascular prostheses |
WO2002014480A2 (en) * | 2000-08-16 | 2002-02-21 | Duke University | Decellularized tissue engineered constructs and tissues |
IL139708A0 (en) * | 2000-11-15 | 2002-02-10 | Amiel Gilad | Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering |
DE10064948C1 (de) | 2000-12-20 | 2002-07-11 | Auto Tissue Gmbh | Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens |
-
2002
- 2002-09-10 JP JP2002264470A patent/JP4092397B2/ja not_active Expired - Lifetime
-
2003
- 2003-09-09 CN CNB038214849A patent/CN1330316C/zh not_active Expired - Lifetime
- 2003-09-09 KR KR1020057004118A patent/KR100869685B1/ko not_active IP Right Cessation
- 2003-09-09 WO PCT/JP2003/011529 patent/WO2004024170A1/ja active Application Filing
- 2003-09-09 EP EP03795344A patent/EP1541157B1/en not_active Expired - Lifetime
- 2003-09-09 US US10/527,312 patent/US20060110720A1/en not_active Abandoned
- 2003-09-09 AU AU2003262030A patent/AU2003262030B2/en not_active Ceased
- 2003-09-09 CA CA2507498A patent/CA2507498C/en not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102470149A (zh) * | 2009-08-18 | 2012-05-23 | 生命细胞公司 | 用于处理组织的方法 |
CN107115567A (zh) * | 2009-08-18 | 2017-09-01 | 生命细胞公司 | 用于处理组织的方法 |
CN107249656A (zh) * | 2015-02-27 | 2017-10-13 | Adeka株式会社 | 脱细胞化组织 |
CN105944142A (zh) * | 2016-05-09 | 2016-09-21 | 拜欧迪赛尔(北京)生物科技有限公司 | 一种新型的脱细胞肌腱或韧带支架的制备方法 |
CN105944142B (zh) * | 2016-05-09 | 2018-07-13 | 拜欧迪赛尔(北京)生物科技有限公司 | 一种脱细胞肌腱或韧带支架的制备方法 |
CN110740762A (zh) * | 2017-05-30 | 2020-01-31 | 株式会社Adeka | 移植用脱细胞化材料制造方法及由包含该材料的生物相容性材料组成的移植片组成物 |
CN115554472A (zh) * | 2022-09-22 | 2023-01-03 | 舩本诚一 | 一种用于移植的生物组织处理方法 |
CN115554472B (zh) * | 2022-09-22 | 2023-08-18 | 舩本诚一 | 一种用于移植的生物组织处理方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1541157A1 (en) | 2005-06-15 |
CA2507498C (en) | 2012-06-05 |
AU2003262030B2 (en) | 2008-09-11 |
EP1541157A4 (en) | 2009-06-24 |
AU2003262030A1 (en) | 2004-04-30 |
US20060110720A1 (en) | 2006-05-25 |
EP1541157B1 (en) | 2012-11-14 |
CN1330316C (zh) | 2007-08-08 |
KR100869685B1 (ko) | 2008-11-21 |
JP4092397B2 (ja) | 2008-05-28 |
KR20050047109A (ko) | 2005-05-19 |
JP2004097552A (ja) | 2004-04-02 |
WO2004024170A1 (ja) | 2004-03-25 |
CA2507498A1 (en) | 2004-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1330316C (zh) | 通过施加超高静水压力的移植用生物体组织的处理方法 | |
AU751506B2 (en) | Process for making compliant dehydrated tissue for implantation | |
Sierad et al. | Design and testing of a pulsatile conditioning system for dynamic endothelialization of polyphenol-stabilized tissue engineered heart valves | |
CN100360190C (zh) | 具有生物活性的人工生物瓣瓣膜的制备方法 | |
CA2771032A1 (en) | Acellular dermal allografts and method of preparation | |
WO2003013239A2 (de) | Verfahren zur devitalisierung natürlicher organe und/oder zur bereitstellung extrazellulärer matrices zum 'tissue-engineering' | |
CN101985051A (zh) | 一种脱细胞角膜或脱细胞角膜基质及其制备方法和用途 | |
JPH02174848A (ja) | 表皮シート並びにその製法、貯蔵方法および用途 | |
CN109675112B (zh) | 一种人源的脱细胞真皮基质的制备方法 | |
CN1325123C (zh) | 通过微波照射处理生物体组织的方法 | |
CN109475663A (zh) | 一种脱细胞猪角膜的制备方法及其脱细胞板层角膜和用法 | |
Gregory et al. | Anyone for a nice cup of tea?: The use of bacterial cellulose for conservation of waterlogged archaeological wood | |
CN109069696A (zh) | 一种脱细胞猪板层干燥角膜及其使用方法和用途 | |
JP2011041716A (ja) | 生体組織の処理方法 | |
CN115737209A (zh) | 一种脱细胞猪带瓣血管的制备方法和应用 | |
CN108339156A (zh) | 去细胞甲床的制备方法以及组织工程化甲床的构建方法 | |
CN103476360A (zh) | 毛发移植材料 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: Osaka Prefecture, Japan Patentee after: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER Patentee after: NIPRO Corp. Address before: Osaka Prefecture, Japan Patentee before: Japan as represented by President of National Cardiovascular Center Patentee before: NIPRO Corp. |
|
CP01 | Change in the name or title of a patent holder | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201026 Address after: Osaka Prefecture, Japan Patentee after: Fujisato toshiya Address before: Osaka Prefecture, Japan Patentee before: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER Patentee before: NIPRO Corp. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210422 Address after: Japan's Kanagawa Prefecture Yokohama Patentee after: Kishida Akio Address before: Osaka Prefecture, Japan Patentee before: Fujisato Toshiya |
|
TR01 | Transfer of patent right | ||
CX01 | Expiry of patent term |
Granted publication date: 20070808 |
|
CX01 | Expiry of patent term |