CN1675204A - 2－杂芳基甲酰胺 - Google Patents

2－杂芳基甲酰胺 Download PDF

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Publication number
CN1675204A
CN1675204A CNA038188511A CN03818851A CN1675204A CN 1675204 A CN1675204 A CN 1675204A CN A038188511 A CNA038188511 A CN A038188511A CN 03818851 A CN03818851 A CN 03818851A CN 1675204 A CN1675204 A CN 1675204A
Authority
CN
China
Prior art keywords
azabicyclo
oct
alkyl
mmol
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038188511A
Other languages
English (en)
Chinese (zh)
Inventor
J·卢伊特勒
F·－G·伯斯
C·埃尔布
F·－T·哈夫纳
K·施尼茨勒
T·弗勒斯纳
M·范坎彭
F·－J·范德施塔伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10257078A external-priority patent/DE10257078A1/de
Priority claimed from DE2002157537 external-priority patent/DE10257537A1/de
Priority claimed from DE10305922A external-priority patent/DE10305922A1/de
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of CN1675204A publication Critical patent/CN1675204A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CNA038188511A 2002-06-10 2003-06-02 2－杂芳基甲酰胺 Pending CN1675204A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10225536 2002-06-10
DE10225536.9 2002-06-10
DE10257078A DE10257078A1 (de) 2002-12-06 2002-12-06 2-Heteroarylcarbonsäureamide
DE10257078.7 2002-12-06
DE10257537.1 2002-12-10
DE2002157537 DE10257537A1 (de) 2002-12-10 2002-12-10 2-Heteroarylcarbonsäureamide
DE10305922.9 2003-02-13
DE10305922A DE10305922A1 (de) 2002-06-10 2003-02-13 2-Heteroarylcarbonsäureamide

Publications (1)

Publication Number Publication Date
CN1675204A true CN1675204A (zh) 2005-09-28

Family

ID=29740887

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038188511A Pending CN1675204A (zh) 2002-06-10 2003-06-02 2－杂芳基甲酰胺

Country Status (16)

Country Link
US (5) US7977485B2 (https=)
EP (1) EP1515967B1 (https=)
JP (1) JP4542891B2 (https=)
CN (1) CN1675204A (https=)
AT (1) ATE344262T1 (https=)
AU (1) AU2003238450A1 (https=)
BR (1) BR0312446A (https=)
CA (1) CA2488761C (https=)
DE (1) DE50305587D1 (https=)
ES (1) ES2276072T3 (https=)
IL (1) IL165505A0 (https=)
MX (1) MXPA04012439A (https=)
NO (1) NO20050063L (https=)
PL (1) PL374551A1 (https=)
UY (1) UY27841A1 (https=)
WO (1) WO2003104227A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205284A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质a的合成方法
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
MXPA04012439A (es) * 2002-06-10 2005-04-19 Bayer Healthcare Ag Amidas de acidos 2-heteroarilcarboxilicos.
MXPA05003317A (es) * 2002-09-25 2005-07-05 Memory Pharm Corp Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
WO2005016923A1 (en) 2003-08-13 2005-02-24 Neurosearch A/S Novel quinuclidine derivatives and their pharmaceutical use
RU2389729C2 (ru) * 2003-12-22 2010-05-20 Мемори Фармасьютиклз Корпорейшн 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение
EP1735306A2 (en) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US7514450B2 (en) 2004-05-19 2009-04-07 Neurosearch A/S Azabicyclic aryl derivatives
DE602005025902D1 (de) 2004-10-15 2011-02-24 Neurosearch As Neue azabizyklische arylderivate und medizinische verwendung damit
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
CN101910159B (zh) * 2007-12-26 2013-06-19 卫材R&D管理有限公司 杂环取代吡啶衍生物的制备方法
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
PE20170923A1 (es) 2010-05-17 2017-07-12 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
CN103380129B (zh) 2010-12-20 2016-04-20 阿克图拉姆生命科学股份公司 2-甲酰胺-4-哌嗪基-苯并呋喃衍生物
KR101928505B1 (ko) * 2011-01-28 2018-12-12 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
EP3461481A1 (en) 2012-05-08 2019-04-03 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
US20230391758A1 (en) * 2020-09-18 2023-12-07 Merck Sharp & Dohme Llc Modified benzofuran-carboxamides as glucosylceramide synthase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
JP4616971B2 (ja) * 2000-07-18 2011-01-19 田辺三菱製薬株式会社 １−アザビシクロアルカン化合物およびその医薬用途
AR036040A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
CA2462453C (en) 2001-10-02 2009-07-28 Pharmacia & Upjohn Company Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
DE10164139A1 (de) * 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
MXPA04012439A (es) * 2002-06-10 2005-04-19 Bayer Healthcare Ag Amidas de acidos 2-heteroarilcarboxilicos.
DE10234424A1 (de) 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205284A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质a的合成方法
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法

Also Published As

Publication number Publication date
US7977485B2 (en) 2011-07-12
UY27841A1 (es) 2003-12-31
US20120258964A1 (en) 2012-10-11
DE50305587D1 (en) 2006-12-14
EP1515967A1 (de) 2005-03-23
US10214524B2 (en) 2019-02-26
EP1515967B1 (de) 2006-11-02
US20140350008A1 (en) 2014-11-27
PL374551A1 (en) 2005-10-31
US20060160877A1 (en) 2006-07-20
US9067931B2 (en) 2015-06-30
NO20050063L (no) 2005-01-06
WO2003104227A1 (de) 2003-12-18
BR0312446A (pt) 2005-04-19
CA2488761C (en) 2011-05-31
JP4542891B2 (ja) 2010-09-15
US20160122337A1 (en) 2016-05-05
JP2005533052A (ja) 2005-11-04
CA2488761A1 (en) 2003-12-18
US20110263591A1 (en) 2011-10-27
MXPA04012439A (es) 2005-04-19
ES2276072T3 (es) 2007-06-16
IL165505A0 (en) 2006-01-15
ATE344262T1 (de) 2006-11-15
AU2003238450A1 (en) 2003-12-22

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