CN1675204A - 2－杂芳基甲酰胺 - Google Patents

2－杂芳基甲酰胺 Download PDF

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Publication number
CN1675204A
CN1675204A CNA038188511A CN03818851A CN1675204A CN 1675204 A CN1675204 A CN 1675204A CN A038188511 A CNA038188511 A CN A038188511A CN 03818851 A CN03818851 A CN 03818851A CN 1675204 A CN1675204 A CN 1675204A
Authority
CN
China
Prior art keywords
amino
alkyl
carbonyl
group
oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038188511A
Other languages
English (en)
Chinese (zh)
Inventor
J·卢伊特勒
F·－G·伯斯
C·埃尔布
F·－T·哈夫纳
K·施尼茨勒
T·弗勒斯纳
M·范坎彭
F·－J·范德施塔伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10257078A external-priority patent/DE10257078A1/de
Priority claimed from DE2002157537 external-priority patent/DE10257537A1/de
Priority claimed from DE10305922A external-priority patent/DE10305922A1/de
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of CN1675204A publication Critical patent/CN1675204A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CNA038188511A 2002-06-10 2003-06-02 2－杂芳基甲酰胺 Pending CN1675204A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10225536 2002-06-10
DE10225536.9 2002-06-10
DE10257078A DE10257078A1 (de) 2002-12-06 2002-12-06 2-Heteroarylcarbonsäureamide
DE10257078.7 2002-12-06
DE10257537.1 2002-12-10
DE2002157537 DE10257537A1 (de) 2002-12-10 2002-12-10 2-Heteroarylcarbonsäureamide
DE10305922A DE10305922A1 (de) 2002-06-10 2003-02-13 2-Heteroarylcarbonsäureamide
DE10305922.9 2003-02-13

Publications (1)

Publication Number Publication Date
CN1675204A true CN1675204A (zh) 2005-09-28

Family

ID=29740887

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038188511A Pending CN1675204A (zh) 2002-06-10 2003-06-02 2－杂芳基甲酰胺

Country Status (16)

Country Link
US (5) US7977485B2 (enExample)
EP (1) EP1515967B1 (enExample)
JP (1) JP4542891B2 (enExample)
CN (1) CN1675204A (enExample)
AT (1) ATE344262T1 (enExample)
AU (1) AU2003238450A1 (enExample)
BR (1) BR0312446A (enExample)
CA (1) CA2488761C (enExample)
DE (1) DE50305587D1 (enExample)
ES (1) ES2276072T3 (enExample)
IL (1) IL165505A0 (enExample)
MX (1) MXPA04012439A (enExample)
NO (1) NO20050063L (enExample)
PL (1) PL374551A1 (enExample)
UY (1) UY27841A1 (enExample)
WO (1) WO2003104227A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205284A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质a的合成方法
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
ATE344262T1 (de) * 2002-06-10 2006-11-15 Bayer Healthcare Ag 2-heteroarylcarbonsäureamide
AU2003276919B2 (en) 2002-09-25 2013-05-16 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
DE602004031124D1 (de) 2003-08-13 2011-03-03 Neurosearch As Neue chinuklidinderivative und deren pharmazeutische verwendung
WO2005063767A2 (en) 2003-12-22 2005-07-14 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
US20050234095A1 (en) 2004-03-25 2005-10-20 Wenge Xie Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US7514450B2 (en) 2004-05-19 2009-04-07 Neurosearch A/S Azabicyclic aryl derivatives
CN100588657C (zh) 2004-10-15 2010-02-10 神经研究公司 新的氮杂双环芳基衍生物及其医药用途
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
CN101910159B (zh) 2007-12-26 2013-06-19 卫材R&D管理有限公司 杂环取代吡啶衍生物的制备方法
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
JP5749797B2 (ja) 2010-05-17 2015-07-15 フォルム ファーマシューティカルズ、インコーポレイテッド （ｒ）−７−クロロ−ｎ−（キヌクリジン−３−イル）ベンゾ［ｂ］チオフェン−２−カルボキサミド塩酸塩一水和物の結晶形
KR20130132932A (ko) 2010-12-20 2013-12-05 아스트라제네카 아베 2-카르복스아미드-4-피페라지닐-벤조푸란 유도체
KR101928505B1 (ko) * 2011-01-28 2018-12-12 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
EP4213832A4 (en) * 2020-09-18 2024-10-16 Merck Sharp & Dohme LLC Modified benzofuran-carboxamides as glucosylceramide synthase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
JP4616971B2 (ja) * 2000-07-18 2011-01-19 田辺三菱製薬株式会社 １−アザビシクロアルカン化合物およびその医薬用途
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
EA007429B1 (ru) 2001-10-02 2006-10-27 Фармация Энд Апджон Компани Азабициклические замещённые конденсированные гетероарильные соединения
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
ATE344262T1 (de) * 2002-06-10 2006-11-15 Bayer Healthcare Ag 2-heteroarylcarbonsäureamide
DE10234424A1 (de) 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205284A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质a的合成方法
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法

Also Published As

Publication number Publication date
US20060160877A1 (en) 2006-07-20
UY27841A1 (es) 2003-12-31
PL374551A1 (en) 2005-10-31
NO20050063L (no) 2005-01-06
US20120258964A1 (en) 2012-10-11
US7977485B2 (en) 2011-07-12
US10214524B2 (en) 2019-02-26
CA2488761C (en) 2011-05-31
WO2003104227A1 (de) 2003-12-18
EP1515967B1 (de) 2006-11-02
AU2003238450A1 (en) 2003-12-22
US20160122337A1 (en) 2016-05-05
BR0312446A (pt) 2005-04-19
JP4542891B2 (ja) 2010-09-15
IL165505A0 (en) 2006-01-15
US20140350008A1 (en) 2014-11-27
MXPA04012439A (es) 2005-04-19
JP2005533052A (ja) 2005-11-04
DE50305587D1 (en) 2006-12-14
EP1515967A1 (de) 2005-03-23
US9067931B2 (en) 2015-06-30
ATE344262T1 (de) 2006-11-15
ES2276072T3 (es) 2007-06-16
CA2488761A1 (en) 2003-12-18
US20110263591A1 (en) 2011-10-27

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