CN1668293A - 使用青蒿素样化合物预防或延缓癌症显现的方法 - Google Patents

使用青蒿素样化合物预防或延缓癌症显现的方法 Download PDF

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Publication number
CN1668293A
CN1668293A CNA038167972A CN03816797A CN1668293A CN 1668293 A CN1668293 A CN 1668293A CN A038167972 A CNA038167972 A CN A038167972A CN 03816797 A CN03816797 A CN 03816797A CN 1668293 A CN1668293 A CN 1668293A
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China
Prior art keywords
free radical
iron
cancer
artemisinin
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Pending
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CNA038167972A
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English (en)
Chinese (zh)
Inventor
H·C·莱
N·P·辛格
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University of Washington
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University of Washington
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CNA038167972A 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法 Pending CN1668293A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692802P 2002-06-06 2002-06-06
US60/386,928 2002-06-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201010165713A Division CN101843904A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法

Publications (1)

Publication Number Publication Date
CN1668293A true CN1668293A (zh) 2005-09-14

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Family Applications (3)

Application Number Title Priority Date Filing Date
CNA038167972A Pending CN1668293A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法
CN201010165713A Pending CN101843904A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法
CNB038167956A Expired - Fee Related CN1313145C (zh) 2002-06-06 2003-06-06 青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201010165713A Pending CN101843904A (zh) 2002-06-06 2003-06-06 使用青蒿素样化合物预防或延缓癌症显现的方法
CNB038167956A Expired - Fee Related CN1313145C (zh) 2002-06-06 2003-06-06 青蒿素相关性内过氧化物与携带铁的蛋白质之间的共价缀合物及其使用方法

Country Status (11)

Country Link
US (2) US20040058981A1 (https=)
EP (2) EP1553935A4 (https=)
JP (2) JP4440768B2 (https=)
CN (3) CN1668293A (https=)
AU (2) AU2003243418B2 (https=)
BR (2) BR0312685A (https=)
CA (2) CA2488347A1 (https=)
NZ (2) NZ537114A (https=)
RU (2) RU2004139090A (https=)
WO (1) WO2003103588A2 (https=)
ZA (1) ZA200500023B (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
CN102395362A (zh) * 2009-04-23 2012-03-28 伦敦制药有限公司 含二氢青蒿素的舌下喷雾制剂
CN102399142A (zh) * 2010-09-14 2012-04-04 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
WO2012136125A1 (zh) * 2011-04-08 2012-10-11 Shi Yanyu 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
WO2014082570A1 (zh) * 2012-11-29 2014-06-05 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途

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EP3257509A1 (en) * 2003-02-12 2017-12-20 Georgetown University Use of artemisinin and related compounds for treating anorectal squamous cell cancer induced by human papilloma virus
US8394365B2 (en) 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
ES2629696T3 (es) * 2003-09-17 2017-08-14 Nektar Therapeutics Profármacos poliméricos multibrazo
CN1255106C (zh) * 2003-09-26 2006-05-10 李国桥 复方青蒿素
US20050096369A1 (en) * 2003-11-04 2005-05-05 Hoang Ba X. Compositions and methods for treating cellular proliferation disorders
EP1686982A4 (en) * 2003-11-19 2007-03-21 Vecta Ltd METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH HELICOBACTER PYLORI USING COMPOUNDS CONTAINING ENDOPEROXIDE BRIDGE
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
US20060270863A1 (en) * 2005-05-27 2006-11-30 Amyris Biotechnologies Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
JP5119155B2 (ja) * 2005-10-20 2013-01-16 エピフアルマ・アクチエンゲゼルシヤフト アルテミシニン及びその誘導体を使用する良性色素性ホクロ（母斑）の処置及び予防
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US20070231300A1 (en) * 2006-03-28 2007-10-04 Washington, University Of Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
WO2008046109A2 (en) * 2006-10-13 2008-04-17 University Of Washington Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
CN101583380B (zh) 2006-11-30 2013-07-10 尼克塔治疗公司 用于制备聚合物轭合物的方法
WO2008098178A2 (en) * 2007-02-09 2008-08-14 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
CN106986926A (zh) * 2008-01-30 2017-07-28 皮里斯股份公司 具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
HUE047352T2 (hu) 2008-09-23 2020-04-28 Nektar Therapeutics Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal)
CA2738807A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
GB2469791B (en) * 2009-04-23 2011-12-14 Londonpharma Ltd Transmucosal formulation of compounds providing dihydroartemesinin for use in the treatment of neoplastic disease
JP5624735B2 (ja) 2009-07-22 2014-11-12 国立大学法人岡山大学 フィルター
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
CN103405779B (zh) * 2013-07-18 2015-09-30 江苏省血吸虫病防治研究所 一种预防血吸虫感染长效青蒿琥酯药物及其制备方法
GB201800736D0 (en) * 2018-01-17 2018-02-28 St Georges Hospital Medical School Combination therapy for treatment of leukemia
CN109908137B (zh) * 2019-03-11 2022-02-18 江苏省人民医院（南京医科大学第一附属医院） 青蒿素在杀伤乳腺癌干细胞的药物中的应用
CN114983999A (zh) * 2022-06-09 2022-09-02 四川大学 一种青蒿素及其衍生物的新用途、验证方法

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CN1084333C (zh) * 1998-06-17 2002-05-08 中国科学院上海药物研究所 新的青蒿素化合物,其制备方法以及含有它们的药物组合物
US6127405A (en) * 1998-07-10 2000-10-03 Council Of Scientific And Industrial Research Method for the use of alpha arteether as an anti-bacterial and anti-fungal agent
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101323569B (zh) * 2008-07-24 2011-01-26 上海交通大学 倍半萜青蒿萜酯ae及其提取纯化方法
CN102395362A (zh) * 2009-04-23 2012-03-28 伦敦制药有限公司 含二氢青蒿素的舌下喷雾制剂
CN102399142A (zh) * 2010-09-14 2012-04-04 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
CN102399142B (zh) * 2010-09-14 2014-09-24 华北制药集团新药研究开发有限责任公司 一类倍半萜酯化合物及其制备方法和用途
WO2012136125A1 (zh) * 2011-04-08 2012-10-11 Shi Yanyu 由溴代双氢青蒿素和Fe2+剂组成的复方双释胶囊制剂
WO2014082570A1 (zh) * 2012-11-29 2014-06-05 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途
CN103845360A (zh) * 2012-11-29 2014-06-11 昆明制药集团股份有限公司 含蒿甲醚的药物组合物、制剂及其用途

Also Published As

Publication number Publication date
CN1313145C (zh) 2007-05-02
RU2325156C2 (ru) 2008-05-27
EP1531851A4 (en) 2007-12-12
JP2005529938A (ja) 2005-10-06
EP1531851A2 (en) 2005-05-25
RU2004139096A (ru) 2005-06-10
EP1553935A2 (en) 2005-07-20
US20080119542A1 (en) 2008-05-22
RU2004139090A (ru) 2005-06-10
JP4440768B2 (ja) 2010-03-24
ZA200500023B (en) 2005-10-20
NZ537114A (en) 2007-02-23
AU2003243418B2 (en) 2009-02-19
EP1531851B1 (en) 2011-12-14
CA2488360A1 (en) 2003-12-18
AU2003251405A1 (en) 2003-12-22
US20040058981A1 (en) 2004-03-25
WO2003103588A2 (en) 2003-12-18
AU2003243418A1 (en) 2003-12-22
EP1553935A4 (en) 2010-07-07
CN1668323A (zh) 2005-09-14
CA2488347A1 (en) 2003-12-18
CN101843904A (zh) 2010-09-29
WO2003103588A3 (en) 2004-04-15
JP2005535606A (ja) 2005-11-24
BR0311627A (pt) 2005-08-30
BR0312685A (pt) 2005-09-06
NZ537113A (en) 2007-01-26

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