CN1656092A - 用于治疗炎性疾病的吗啉基－脲衍生物 - Google Patents
用于治疗炎性疾病的吗啉基－脲衍生物 Download PDFInfo
- Publication number
- CN1656092A CN1656092A CNA038115506A CN03811550A CN1656092A CN 1656092 A CN1656092 A CN 1656092A CN A038115506 A CNA038115506 A CN A038115506A CN 03811550 A CN03811550 A CN 03811550A CN 1656092 A CN1656092 A CN 1656092A
- Authority
- CN
- China
- Prior art keywords
- methyl
- base
- compound
- formula
- morpholine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207434.2 | 2002-03-28 | ||
| GB0207434A GB0207434D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| GB0301608A GB0301608D0 (en) | 2003-01-24 | 2003-01-24 | Novel compounds |
| GB0301608.6 | 2003-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1656092A true CN1656092A (zh) | 2005-08-17 |
Family
ID=28676494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA038115506A Pending CN1656092A (zh) | 2002-03-28 | 2003-03-27 | 用于治疗炎性疾病的吗啉基－脲衍生物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7622464B2 (https=) |
| EP (1) | EP1487828B1 (https=) |
| JP (1) | JP4465195B2 (https=) |
| KR (1) | KR20040093488A (https=) |
| CN (1) | CN1656092A (https=) |
| AR (1) | AR040403A1 (https=) |
| AT (1) | ATE413399T1 (https=) |
| AU (1) | AU2003226757A1 (https=) |
| BR (1) | BR0308780A (https=) |
| CA (1) | CA2480106A1 (https=) |
| CY (1) | CY1108652T1 (https=) |
| DE (1) | DE60324535D1 (https=) |
| DK (1) | DK1487828T3 (https=) |
| ES (1) | ES2315519T3 (https=) |
| IL (1) | IL164047A0 (https=) |
| IS (1) | IS7444A (https=) |
| MX (1) | MXPA04009459A (https=) |
| NO (1) | NO20044448L (https=) |
| PT (1) | PT1487828E (https=) |
| RU (1) | RU2004127928A (https=) |
| SI (1) | SI1487828T1 (https=) |
| TW (1) | TW200400035A (https=) |
| WO (1) | WO2003082861A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019015279A1 (zh) * | 2017-07-20 | 2019-01-24 | 复旦大学 | Sirt1抑制剂在预防和治疗放射引起的肠道疾病中的应用 |
| CN119330881A (zh) * | 2024-09-06 | 2025-01-21 | 苏州汉德创宏生化科技有限公司 | 一种3-氨甲基-1-h吡唑的合成方法 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2511970C (en) | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Urea derivatives useful in the treatment of heart failure |
| CA2520763A1 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| JP5080970B2 (ja) | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
| MXPA06015049A (es) | 2004-07-08 | 2007-02-08 | Novo Nordisk As | Marcadores prolongadores de polipeptidos que comprenden una porcion tetrazol. |
| US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
| CA2579207C (en) | 2004-09-08 | 2011-10-18 | Mitsubishi Pharma Corporation | Morpholine compound |
| US7662910B2 (en) | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
| EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| AU2008293542B9 (en) | 2007-08-27 | 2014-08-07 | Dart Neuroscience (Cayman) Ltd. | Therapeutic isoxazole compounds |
| EP2528604B1 (en) | 2010-01-29 | 2017-11-22 | The Regents of the University of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| RU2512293C1 (ru) * | 2012-12-13 | 2014-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" | Способ получения этил 1,2,4-оксадиазол-5-карбоксилатов |
| WO2022023496A2 (en) * | 2020-07-29 | 2022-02-03 | Universidade De Santiago De Compostela | Functionalized isonitriles and products, preparation and uses thereof |
| WO2022031735A1 (en) * | 2020-08-03 | 2022-02-10 | Global Blood Therapeutics, Inc. | Urea derivatives as pyruvate kinase activators |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851526A (en) | 1987-09-04 | 1989-07-25 | Schering A.G. | 1-(4-Substituted phenyl)-1H-imidazoles compounds |
| JP3087763B2 (ja) | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
| US5219856A (en) | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| WO1995032196A1 (en) | 1994-05-19 | 1995-11-30 | Merck Sharp & Dohme Limited | Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists |
| NZ290788A (en) | 1994-07-20 | 1999-07-29 | Byk Gulden Lomberg Chem Fab | Piperazine thiopyridines; used for controlling helicobacter bacteria |
| US5654316A (en) | 1995-06-06 | 1997-08-05 | Schering Corporation | Piperidine derivatives as neurokinin antagonists |
| JP3531169B2 (ja) | 1996-06-11 | 2004-05-24 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| US5919776A (en) | 1996-12-20 | 1999-07-06 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| IT1293807B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| AU1122399A (en) | 1997-10-27 | 1999-05-17 | Neurogen Corporation | Novel 1-(n'-(arylalkylaminoalkyl))aminoisoindoles; a new class of dopamine receptor subtype specific ligands |
| US6031097A (en) | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| CN1325397A (zh) | 1998-09-30 | 2001-12-05 | 纽罗根公司 | 2－哌嗪烷基氨基苯并吡咯衍生物∶多巴胺受体亚型特异配体 |
| IL155093A0 (en) | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Morpholin-acetamide derivatives for the treatment on inflammatory diseases |
| IL155092A0 (en) * | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
-
2003
- 2003-03-26 TW TW092106766A patent/TW200400035A/zh unknown
- 2003-03-27 CN CNA038115506A patent/CN1656092A/zh active Pending
- 2003-03-27 JP JP2003580326A patent/JP4465195B2/ja not_active Expired - Lifetime
- 2003-03-27 US US10/509,162 patent/US7622464B2/en not_active Expired - Lifetime
- 2003-03-27 KR KR10-2004-7015398A patent/KR20040093488A/ko not_active Withdrawn
- 2003-03-27 PT PT03745294T patent/PT1487828E/pt unknown
- 2003-03-27 MX MXPA04009459A patent/MXPA04009459A/es unknown
- 2003-03-27 DE DE60324535T patent/DE60324535D1/de not_active Expired - Lifetime
- 2003-03-27 EP EP03745294A patent/EP1487828B1/en not_active Expired - Lifetime
- 2003-03-27 SI SI200331471T patent/SI1487828T1/sl unknown
- 2003-03-27 DK DK03745294T patent/DK1487828T3/da active
- 2003-03-27 AT AT03745294T patent/ATE413399T1/de active
- 2003-03-27 WO PCT/EP2003/003335 patent/WO2003082861A2/en not_active Ceased
- 2003-03-27 CA CA002480106A patent/CA2480106A1/en not_active Abandoned
- 2003-03-27 AR AR20030101081A patent/AR040403A1/es unknown
- 2003-03-27 ES ES03745294T patent/ES2315519T3/es not_active Expired - Lifetime
- 2003-03-27 IL IL16404703A patent/IL164047A0/xx unknown
- 2003-03-27 AU AU2003226757A patent/AU2003226757A1/en not_active Abandoned
- 2003-03-27 BR BR0308780-8A patent/BR0308780A/pt not_active Application Discontinuation
- 2003-03-27 RU RU2004127928/04A patent/RU2004127928A/ru not_active Application Discontinuation
-
2004
- 2004-09-13 IS IS7444A patent/IS7444A/is unknown
- 2004-10-19 NO NO20044448A patent/NO20044448L/no not_active Application Discontinuation
-
2008
- 2008-12-19 CY CY20081101474T patent/CY1108652T1/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019015279A1 (zh) * | 2017-07-20 | 2019-01-24 | 复旦大学 | Sirt1抑制剂在预防和治疗放射引起的肠道疾病中的应用 |
| CN119330881A (zh) * | 2024-09-06 | 2025-01-21 | 苏州汉德创宏生化科技有限公司 | 一种3-氨甲基-1-h吡唑的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE413399T1 (de) | 2008-11-15 |
| IS7444A (is) | 2004-09-13 |
| IL164047A0 (en) | 2005-12-18 |
| NO20044448L (no) | 2004-10-26 |
| AU2003226757A1 (en) | 2003-10-13 |
| ES2315519T3 (es) | 2009-04-01 |
| TW200400035A (en) | 2004-01-01 |
| US20060063765A1 (en) | 2006-03-23 |
| CY1108652T1 (el) | 2014-08-13 |
| SI1487828T1 (sl) | 2009-04-30 |
| CA2480106A1 (en) | 2003-10-09 |
| WO2003082861A3 (en) | 2004-03-11 |
| JP4465195B2 (ja) | 2010-05-19 |
| US7622464B2 (en) | 2009-11-24 |
| RU2004127928A (ru) | 2005-06-27 |
| EP1487828B1 (en) | 2008-11-05 |
| DK1487828T3 (da) | 2009-02-02 |
| PT1487828E (pt) | 2009-01-06 |
| DE60324535D1 (de) | 2008-12-18 |
| KR20040093488A (ko) | 2004-11-05 |
| EP1487828A2 (en) | 2004-12-22 |
| JP2005526815A (ja) | 2005-09-08 |
| WO2003082861A2 (en) | 2003-10-09 |
| MXPA04009459A (es) | 2005-01-25 |
| AR040403A1 (es) | 2005-04-06 |
| BR0308780A (pt) | 2004-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1656092A (zh) | 用于治疗炎性疾病的吗啉基－脲衍生物 | |
| CN1273466C (zh) | 具有唑基的喹啉衍生物和喹唑啉衍生物 | |
| CN1289500C (zh) | 氮杂双环化合物,它们的制备方法以及它们作为药物的应用,特别地作为抗菌剂的应用 | |
| CN1179945C (zh) | 吲哚衍生物、其制备方法及用途 | |
| CN1304382C (zh) | 用于治疗炎性、免疫或心血管疾病的新的p2x7受体拮抗剂 | |
| CN1145616C (zh) | 新的氨基三唑化合物,其制备方法及包含它们的药物组合物 | |
| CN1195762C (zh) | 新的2－（亚氨基甲基）氨基－苯基衍生物、其制备、作为药物的应用以及含有它们的药物组合物 | |
| CN1313450C (zh) | 速激肽受体拮抗剂 | |
| CN1678594A (zh) | 用于治疗炎性疾病的吗啉－乙酰胺衍生物 | |
| HK1041486A1 (zh) | 作為前列腺素e2激動劑或拮抗劑的噁唑化合物 | |
| CN1930143A (zh) | 具有微粒体甘油三酸酯传递蛋白质抑制活性的被五元杂环取代的芳基哌啶或哌嗪 | |
| CN1646502A (zh) | 用作速激肽受体拮抗剂的三唑衍生物 | |
| CN1575284A (zh) | 作为激酶抑制剂的取代的三唑二胺衍生物 | |
| CN1674892A (zh) | 杂联芳基衍生物作为基质金属蛋白酶抑制剂 | |
| CN1099755A (zh) | 环状衍生物、含该衍生物的药物组合物及制备方法 | |
| CN1197458A (zh) | 具有磷酯酶a2抑制活性的吡咯烷衍生物 | |
| CN1802369A (zh) | Cgrp受体拮抗剂 | |
| CN1305993A (zh) | 用作氧化氮合成酶抑制剂的环状脒基制剂 | |
| CN1642927A (zh) | 环状酰胺 | |
| CN1014790B (zh) | 新型苯并唑基及苯并噻唑基胺类衍生物的制备方法及其应用 | |
| CN1152873C (zh) | 新的二苯基哌啶衍生物 | |
| CN1922139A (zh) | 双环酰胺衍生物 | |
| CN101031555A (zh) | 具有vap－1抑制活性的噻唑衍生物 | |
| CN1035817C (zh) | 三唑基取代的叔胺化合物及其盐的制备方法 | |
| CN1152879C (zh) | 萘啶衍生物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |