CN1638830A - 用于沙美特罗羟萘甲酸盐的计量的定量吸入器 - Google Patents
用于沙美特罗羟萘甲酸盐的计量的定量吸入器 Download PDFInfo
- Publication number
- CN1638830A CN1638830A CNA018228275A CN01822827A CN1638830A CN 1638830 A CN1638830 A CN 1638830A CN A018228275 A CNA018228275 A CN A018228275A CN 01822827 A CN01822827 A CN 01822827A CN 1638830 A CN1638830 A CN 1638830A
- Authority
- CN
- China
- Prior art keywords
- container
- valve
- coating
- jar
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/003—Articles enclosed in rigid or semi-rigid containers, the whole being wrapped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/38—Details of the container body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0031502.8 | 2000-12-22 | ||
| GB0031502A GB0031502D0 (en) | 2000-12-22 | 2000-12-22 | Aerosol formulation |
| GB0128612A GB0128612D0 (en) | 2001-11-29 | 2001-11-29 | Aerosol formulations |
| GB0128612.9 | 2001-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1638830A true CN1638830A (zh) | 2005-07-13 |
Family
ID=26245483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA018228275A Pending CN1638830A (zh) | 2000-12-22 | 2001-12-21 | 用于沙美特罗羟萘甲酸盐的计量的定量吸入器 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040050960A1 (https=) |
| EP (1) | EP1343550B1 (https=) |
| JP (2) | JP2004520107A (https=) |
| KR (1) | KR100881258B1 (https=) |
| CN (1) | CN1638830A (https=) |
| AU (1) | AU2002222304B2 (https=) |
| BR (1) | BR0116396A (https=) |
| CA (1) | CA2431910A1 (https=) |
| CZ (1) | CZ305498B6 (https=) |
| ES (1) | ES2656210T3 (https=) |
| HU (1) | HU229899B1 (https=) |
| IL (2) | IL156308A0 (https=) |
| MX (1) | MXPA03005697A (https=) |
| NO (1) | NO336840B1 (https=) |
| NZ (1) | NZ526564A (https=) |
| PL (1) | PL204659B1 (https=) |
| WO (1) | WO2002051483A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366406A (zh) * | 2011-10-21 | 2012-03-07 | 江阴长风医药科技有限公司 | 以氢氟烷烃为抛射剂的沙美特罗替卡松气雾剂制剂 |
| CN109519579A (zh) * | 2018-12-26 | 2019-03-26 | 万通(苏州)定量阀系统有限公司 | 阀门 |
| CN112438966A (zh) * | 2019-08-30 | 2021-03-05 | 四川普锐特药业有限公司 | 一种医用定量吸入气雾剂 |
| CN115445033A (zh) * | 2017-10-09 | 2022-12-09 | 珍珠治疗公司 | 药物递送系统及相关方法 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| IL150654A (en) * | 2002-07-09 | 2006-12-10 | Ori Lerman | Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate |
| US7879833B2 (en) * | 2002-12-12 | 2011-02-01 | Nycomed Gmbh | Combination medicament |
| WO2004093950A1 (en) * | 2003-04-22 | 2004-11-04 | Glaxo Group Limited | A medicament dispenser |
| AU2004241746A1 (en) * | 2003-05-22 | 2004-12-02 | Nycomed Gmbh | Salmeterol and ciclesonide combination |
| MXPA05013324A (es) * | 2003-06-10 | 2006-03-09 | Astellas Pharma Inc | Preparacion de aerosol comprendiendo un anexo que incluye una composicion de aerosol conteniendo compuesto macrolido. |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| WO2005011783A1 (en) * | 2003-07-31 | 2005-02-10 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
| AU2004264941B2 (en) * | 2003-08-11 | 2008-11-27 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
| EP1658105B1 (en) | 2003-08-29 | 2018-03-14 | Glaxo Group Limited | Pharmaceutical metered dose inhaler and methods relating thereto |
| GB2406096B (en) * | 2003-09-16 | 2008-05-21 | Bespak Plc | A pharmaceutical metered dose aerosol inhaler device |
| PT1670482E (pt) * | 2003-09-16 | 2014-03-12 | Takeda Gmbh | Utilização de ciclesonida para o tratamento de doenças respiratórias |
| US20070134165A1 (en) * | 2004-04-20 | 2007-06-14 | Altana Pharma Ag | Use of Ciclesonide for the Treatment of Respiratory Disease in a Smoking Patient |
| FR2872494B1 (fr) * | 2004-07-01 | 2006-11-17 | Valois Sas | Distributeur de produits fluide ou pulverisant |
| ATE509863T1 (de) | 2005-10-21 | 2011-06-15 | Btg Int Ltd | Aerosolventil |
| KR100870305B1 (ko) * | 2007-05-17 | 2008-11-25 | 엘에스전선 주식회사 | 절연전선용 피복재 및 이를 이용하여 형성된 절연전선 |
| WO2009061891A2 (en) * | 2007-11-06 | 2009-05-14 | 3M Innovative Properties Company | Medicinal inhalation devices and components thereof |
| KR20110040844A (ko) * | 2008-07-11 | 2011-04-20 | 맵 파마슈티컬스, 인코포레이티드 | 에어로졸 약물 전달을 위한 용기 |
| DE102009041132B4 (de) * | 2009-09-14 | 2014-08-14 | Schott Ag | Verfahren zur Herstellung einer Gleitschicht und pharmazeutisches Packmittel mit Gleitschicht |
| DE102011009057B4 (de) | 2011-01-20 | 2015-12-10 | Schott Ag | Plasma-Behandlungsvorrichtung zur Herstellung von Beschichtungen und Verfahren zur innenseitigen Plasmabehandlung von Behältern |
| GB201118188D0 (en) * | 2011-10-21 | 2011-12-07 | 3M Innovative Properties Co | Manufacture of medicinal aerosol canisters |
| EP2819669B1 (de) * | 2012-02-28 | 2021-04-21 | Boehringer Ingelheim International GmbH | Neue treibgashaltige tiotropium-formulierung |
| FR3035382B1 (fr) * | 2015-04-24 | 2019-10-18 | Nemera La Verpilliere | Valve doseuse perfectionnee de distribution d'un aerosol comprenant une tige de valve |
| US20160361514A1 (en) * | 2015-06-15 | 2016-12-15 | Consort Medical Plc | Dispensing apparatus |
| WO2019025994A2 (en) * | 2017-08-03 | 2019-02-07 | 3M Innovative Properties Company | COATING PROCESS |
| US20190076607A1 (en) * | 2017-09-13 | 2019-03-14 | Lupin Atlantis Holdings Sa | Inhaler and mesh for an inhaler |
| US12329727B2 (en) | 2020-04-24 | 2025-06-17 | The Medical College Of Wisconsin, Inc. | Use of salmeterol as an anti-coronaviral agent |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3405846A (en) * | 1966-06-24 | 1968-10-15 | Union Carbide Corp | Aerosol valve |
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| DE69131867T2 (de) | 1990-03-23 | 2000-05-18 | Minnesota Mining And Mfg. Co., Saint Paul | Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| CA2166970C (en) * | 1993-07-15 | 2000-12-19 | Oh-Seung Kwon | Seals for use in an aerosol delivery device |
| US6596260B1 (en) * | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| TR199701170T1 (xx) | 1995-04-14 | 1998-02-21 | Glaxo Wellcome Inc. | Beklometazon dipropionat i�in �l��lm�� doz inhaleri. |
| TR199701169T1 (xx) * | 1995-04-14 | 1998-03-21 | Glaxo Wellcome Inc. | Salmeterol i�in �l��lm�� doz inhaleri. |
| HU219900B (hu) * | 1995-04-14 | 2001-09-28 | Glaxo Wellcome Inc. | Mért dózist adagoló inhalálóberendezés |
| HU219899B (hu) * | 1995-04-14 | 2001-09-28 | Glaxo Wellcome Inc. | Inhalálóberendezés flutikaszon-propionát adagolására mért dózisban |
| DE19835273A1 (de) * | 1997-09-03 | 1999-03-04 | Bespak Plc | Dosierventil für einen Druck-Abgabe-Behälter |
| EP1086962B1 (en) * | 1998-03-06 | 2003-10-01 | Daikin Industries, Ltd. | Fluorochemical adhesive material and laminate made with the same |
| GB9805938D0 (en) * | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| GB9807232D0 (en) * | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| US6390291B1 (en) * | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6352152B1 (en) * | 1998-12-18 | 2002-03-05 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6315112B1 (en) * | 1998-12-18 | 2001-11-13 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| US6119853A (en) * | 1998-12-18 | 2000-09-19 | Glaxo Wellcome Inc. | Method and package for storing a pressurized container containing a drug |
| GB9906640D0 (en) * | 1999-03-24 | 1999-05-19 | Glaxo Group Ltd | Valve |
| DK1169019T3 (da) * | 1999-04-14 | 2003-06-02 | Glaxo Group Ltd | Farmaceutisk aerosolformulering |
| US6739333B1 (en) * | 1999-05-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Stainless steel canister for propellant-driven metering aerosols |
| GB9918627D0 (en) * | 1999-08-07 | 1999-10-13 | Glaxo Group Ltd | Valve |
| GB0008485D0 (en) * | 2000-04-07 | 2000-05-24 | Glaxo Group Ltd | Pharmaceutical compositions |
-
2001
- 2001-12-21 CZ CZ2003-1742A patent/CZ305498B6/cs unknown
- 2001-12-21 BR BR0116396-5A patent/BR0116396A/pt not_active Application Discontinuation
- 2001-12-21 NZ NZ526564A patent/NZ526564A/xx not_active IP Right Cessation
- 2001-12-21 WO PCT/GB2001/005749 patent/WO2002051483A1/en not_active Ceased
- 2001-12-21 CN CNA018228275A patent/CN1638830A/zh active Pending
- 2001-12-21 ES ES01272108.0T patent/ES2656210T3/es not_active Expired - Lifetime
- 2001-12-21 AU AU2002222304A patent/AU2002222304B2/en not_active Expired
- 2001-12-21 US US10/451,444 patent/US20040050960A1/en not_active Abandoned
- 2001-12-21 PL PL364773A patent/PL204659B1/pl unknown
- 2001-12-21 MX MXPA03005697A patent/MXPA03005697A/es active IP Right Grant
- 2001-12-21 JP JP2002552624A patent/JP2004520107A/ja active Pending
- 2001-12-21 CA CA002431910A patent/CA2431910A1/en not_active Abandoned
- 2001-12-21 IL IL15630801A patent/IL156308A0/xx active IP Right Grant
- 2001-12-21 HU HU0400600A patent/HU229899B1/hu unknown
- 2001-12-21 EP EP01272108.0A patent/EP1343550B1/en not_active Expired - Lifetime
- 2001-12-21 KR KR1020037008530A patent/KR100881258B1/ko not_active Expired - Lifetime
-
2003
- 2003-06-04 IL IL156308A patent/IL156308A/en unknown
- 2003-06-20 NO NO20032836A patent/NO336840B1/no not_active IP Right Cessation
-
2009
- 2009-02-03 JP JP2009022343A patent/JP2009142663A/ja active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366406A (zh) * | 2011-10-21 | 2012-03-07 | 江阴长风医药科技有限公司 | 以氢氟烷烃为抛射剂的沙美特罗替卡松气雾剂制剂 |
| CN102366406B (zh) * | 2011-10-21 | 2013-10-09 | 江苏长风药业有限公司 | 以氢氟烷烃为抛射剂的沙美特罗替卡松气雾剂制剂 |
| CN115445033A (zh) * | 2017-10-09 | 2022-12-09 | 珍珠治疗公司 | 药物递送系统及相关方法 |
| CN109519579A (zh) * | 2018-12-26 | 2019-03-26 | 万通(苏州)定量阀系统有限公司 | 阀门 |
| CN112438966A (zh) * | 2019-08-30 | 2021-03-05 | 四川普锐特药业有限公司 | 一种医用定量吸入气雾剂 |
| CN112438966B (zh) * | 2019-08-30 | 2022-08-26 | 四川普锐特药业有限公司 | 一种医用定量吸入气雾剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03005697A (es) | 2003-10-06 |
| NO20032836D0 (no) | 2003-06-20 |
| CZ305498B6 (cs) | 2015-11-04 |
| PL204659B1 (pl) | 2010-01-29 |
| HUP0400600A2 (hu) | 2004-06-28 |
| EP1343550A1 (en) | 2003-09-17 |
| JP2004520107A (ja) | 2004-07-08 |
| AU2002222304B2 (en) | 2004-03-18 |
| KR100881258B1 (ko) | 2009-02-05 |
| WO2002051483A1 (en) | 2002-07-04 |
| JP2009142663A (ja) | 2009-07-02 |
| BR0116396A (pt) | 2003-11-11 |
| CA2431910A1 (en) | 2002-07-04 |
| US20040050960A1 (en) | 2004-03-18 |
| IL156308A0 (en) | 2004-01-04 |
| EP1343550B1 (en) | 2017-11-22 |
| KR20040012701A (ko) | 2004-02-11 |
| IL156308A (en) | 2011-03-31 |
| NO336840B1 (no) | 2015-11-16 |
| PL364773A1 (pl) | 2004-12-13 |
| NZ526564A (en) | 2004-12-24 |
| CZ20031742A3 (cs) | 2004-01-14 |
| HU229899B1 (en) | 2014-12-29 |
| ES2656210T3 (es) | 2018-02-26 |
| NO20032836L (no) | 2003-08-15 |
| HUP0400600A3 (en) | 2008-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20050713 |