CN1626504A - 托特罗定及其酒石酸盐的制备方法 - Google Patents
托特罗定及其酒石酸盐的制备方法 Download PDFInfo
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- CN1626504A CN1626504A CN 200410058502 CN200410058502A CN1626504A CN 1626504 A CN1626504 A CN 1626504A CN 200410058502 CN200410058502 CN 200410058502 CN 200410058502 A CN200410058502 A CN 200410058502A CN 1626504 A CN1626504 A CN 1626504A
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- acid
- tolterodine
- tartrate
- reaction
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200410058502 CN1245377C (zh) | 2004-08-16 | 2004-08-16 | 托特罗定及其酒石酸盐的制备方法 |
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CN 200410058502 CN1245377C (zh) | 2004-08-16 | 2004-08-16 | 托特罗定及其酒石酸盐的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1626504A true CN1626504A (zh) | 2005-06-15 |
CN1245377C CN1245377C (zh) | 2006-03-15 |
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CN 200410058502 Expired - Fee Related CN1245377C (zh) | 2004-08-16 | 2004-08-16 | 托特罗定及其酒石酸盐的制备方法 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1693361A1 (en) | 2005-02-18 | 2006-08-23 | Dipharma S.p.A. | A process for the preparation of tolterodine |
JP2008525360A (ja) * | 2004-12-24 | 2008-07-17 | レツク・フアーマシユーテイカルズ・デー・デー | 3−(2−ヒドロキシ−5−メチルフェニル)−n,n−ジイソプロピル−3−フェニルプロピルアミンの製造プロセス |
WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
CN103044274A (zh) * | 2012-11-29 | 2013-04-17 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
CN110229072A (zh) * | 2019-06-25 | 2019-09-13 | 中国药科大学 | 一种托特罗定及其对映体的合成方法 |
CN111925294A (zh) * | 2020-07-06 | 2020-11-13 | 济南大学 | 一种托特罗定帕莫酸盐及其制备方法 |
CN114213265A (zh) * | 2021-12-22 | 2022-03-22 | 南京美瑞制药有限公司 | 一种制备托特罗定氧化杂质的方法 |
-
2004
- 2004-08-16 CN CN 200410058502 patent/CN1245377C/zh not_active Expired - Fee Related
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008525360A (ja) * | 2004-12-24 | 2008-07-17 | レツク・フアーマシユーテイカルズ・デー・デー | 3−(2−ヒドロキシ−5−メチルフェニル)−n,n−ジイソプロピル−3−フェニルプロピルアミンの製造プロセス |
AU2005318426B2 (en) * | 2004-12-24 | 2011-05-19 | Lek Pharmaceuticals D.D. | Process for preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine |
EP1693361A1 (en) | 2005-02-18 | 2006-08-23 | Dipharma S.p.A. | A process for the preparation of tolterodine |
WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
CN103044274A (zh) * | 2012-11-29 | 2013-04-17 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
CN103044274B (zh) * | 2012-11-29 | 2014-10-22 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
CN110229072A (zh) * | 2019-06-25 | 2019-09-13 | 中国药科大学 | 一种托特罗定及其对映体的合成方法 |
CN110229072B (zh) * | 2019-06-25 | 2022-04-08 | 中国药科大学 | 一种托特罗定及其对映体的合成方法 |
CN111925294A (zh) * | 2020-07-06 | 2020-11-13 | 济南大学 | 一种托特罗定帕莫酸盐及其制备方法 |
CN114213265A (zh) * | 2021-12-22 | 2022-03-22 | 南京美瑞制药有限公司 | 一种制备托特罗定氧化杂质的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1245377C (zh) | 2006-03-15 |
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GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: LUNNAN BETTER PHARMACEUTICAL Co.,Ltd. Assignor: LUNAN PHARMACEUTICAL Group Corp. Contract record no.: 2010370000513 Denomination of invention: Method for preparing Tolterodine and tartrate Granted publication date: 20060315 License type: Exclusive License Open date: 20050615 Record date: 20100909 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: LUNNAN BETTER PHARMACEUTICAL Co.,Ltd. Assignor: LUNAN PHARMACEUTICAL Group Corp. Contract record no.: 2010370000513 Date of cancellation: 20131016 |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060315 |
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CF01 | Termination of patent right due to non-payment of annual fee |