CN1617928A - 聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 - Google Patents
聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 Download PDFInfo
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- CN1617928A CN1617928A CNA02827640XA CN02827640A CN1617928A CN 1617928 A CN1617928 A CN 1617928A CN A02827640X A CNA02827640X A CN A02827640XA CN 02827640 A CN02827640 A CN 02827640A CN 1617928 A CN1617928 A CN 1617928A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
Abstract
Description
共聚物 | N(UFCG) | W(PEI) | Mw | DNA/寡聚物结合 | 转染psDNA | 转染寡聚物 |
PEG-15PA-PEI400 | 0.0 | 2,344(10%) | 23,444 | + | - | - |
PEG-15PA-PEI800 | 0.0 | 8,400(30%) | 28,400 | + | + | + |
PEG-8PA-PEI800 | 0.0 | 2,607(11.5%) | 22,607 | + | - | + |
PEG-10PA-PEI1200 | 0.0 | 4,963(20.0%) | 24,936 | + | + | + |
PEG-8PA-PEI2K | 0.0 | 7,490(27%) | 27,490 | + | + | + |
PEG-15PA-GFLG-PEI400 | 9.0 | 2,000(7.8%) | 25,400 | - | - | - |
PEG-15PA-GFLG-PEI800 | 9.0 | 4,400(15.8%) | 27,900 | + | + | + |
PEG-8PA-GFLG-PEI400 | 3.8 | 1,087(4.8%) | 22,577 | + | - | + |
PEG-8PA-GFLG-PEI800 | 3.8 | 2.207(9.3%) | 23,697 | + | + | + |
PEG-8PA-GFLG-PEI2K | 3.8 | 4,975(18,8%) | 26.465 | + | + | + |
对照: | ||||||
PEI-25K(购自Sigma) | 25,000 | + | + | + | ||
PEI-2K(购自Polysciences) | 1,800 | + | - | + | ||
PEI-400(购自Sigma) | 400 | - | - | - |
Claims (64)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/996,507 US7060498B1 (en) | 2001-11-28 | 2001-11-28 | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
US09/996,507 | 2001-11-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1617928A true CN1617928A (zh) | 2005-05-18 |
CN1330765C CN1330765C (zh) | 2007-08-08 |
Family
ID=25542997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB02827640XA Expired - Fee Related CN1330765C (zh) | 2001-11-28 | 2002-06-26 | 聚阳离子水溶性共聚物和将聚阴离子大分子跨生物屏障传递的方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7060498B1 (zh) |
EP (1) | EP1461436A4 (zh) |
JP (1) | JP2005510572A (zh) |
CN (1) | CN1330765C (zh) |
AU (1) | AU2002345981B2 (zh) |
CA (1) | CA2468548A1 (zh) |
HK (1) | HK1078103A1 (zh) |
MX (1) | MXPA04005194A (zh) |
WO (1) | WO2003046185A1 (zh) |
Cited By (3)
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CN102154350A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化枸杞多糖纳米粒基因传递系统及其制法 |
CN102154349A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN112135838A (zh) * | 2018-03-29 | 2020-12-25 | 日油株式会社 | 分解性聚乙二醇键合物 |
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US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102154350A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化枸杞多糖纳米粒基因传递系统及其制法 |
CN102154349A (zh) * | 2010-12-30 | 2011-08-17 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN102154349B (zh) * | 2010-12-30 | 2014-08-06 | 江苏大学 | 阳离子化的桑叶多糖纳米粒基因载体及其制法 |
CN112135838A (zh) * | 2018-03-29 | 2020-12-25 | 日油株式会社 | 分解性聚乙二醇键合物 |
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EP1461436A4 (en) | 2006-03-22 |
JP2005510572A (ja) | 2005-04-21 |
HK1078103A1 (en) | 2006-03-03 |
AU2002345981B2 (en) | 2007-11-01 |
WO2003046185A1 (en) | 2003-06-05 |
EP1461436A1 (en) | 2004-09-29 |
AU2002345981A1 (en) | 2003-06-10 |
MXPA04005194A (es) | 2005-06-20 |
CN1330765C (zh) | 2007-08-08 |
US7060498B1 (en) | 2006-06-13 |
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