CN1610752A - 多参数全面分析核酸以及同样样品上的形态学特征 - Google Patents

多参数全面分析核酸以及同样样品上的形态学特征 Download PDF

Info

Publication number
CN1610752A
CN1610752A CNA028261313A CN02826131A CN1610752A CN 1610752 A CN1610752 A CN 1610752A CN A028261313 A CNA028261313 A CN A028261313A CN 02826131 A CN02826131 A CN 02826131A CN 1610752 A CN1610752 A CN 1610752A
Authority
CN
China
Prior art keywords
cell
rna
group
analysis
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028261313A
Other languages
English (en)
Chinese (zh)
Inventor
S·M·奥哈拉
D·兹维茨
B·福尔克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp filed Critical Immunivest Corp
Publication of CN1610752A publication Critical patent/CN1610752A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/54333Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00Electrophoretic profiling, e.g. for proteome analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Dentistry (AREA)
  • Oncology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNA028261313A 2001-10-26 2002-10-28 多参数全面分析核酸以及同样样品上的形态学特征 Pending CN1610752A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33066901P 2001-10-26 2001-10-26
US60/330,669 2001-10-26
US36994502P 2002-04-04 2002-04-04
US60/369,945 2002-04-04

Publications (1)

Publication Number Publication Date
CN1610752A true CN1610752A (zh) 2005-04-27

Family

ID=26987390

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028261313A Pending CN1610752A (zh) 2001-10-26 2002-10-28 多参数全面分析核酸以及同样样品上的形态学特征

Country Status (9)

Country Link
EP (2) EP1438419A2 (fr)
JP (1) JP2005507997A (fr)
KR (1) KR20040047971A (fr)
CN (1) CN1610752A (fr)
AU (1) AU2002360305A1 (fr)
BR (1) BR0213520A (fr)
CA (2) CA2465288A1 (fr)
IL (1) IL161357A0 (fr)
WO (2) WO2003035894A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102109525A (zh) * 2011-01-26 2011-06-29 牛刚 一种检测血液中游离乳腺癌细胞标志物的试剂盒
CN102156164A (zh) * 2011-01-13 2011-08-17 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN102565404A (zh) * 2010-12-24 2012-07-11 牛刚 一种检测血液中游离大肠癌细胞标志物的试剂盒
CN105102960A (zh) * 2013-03-15 2015-11-25 艾瑞思国际股份有限公司 用于对尿液样品进行染色和处理的方法和组合物
CN105807038A (zh) * 2007-02-01 2016-07-27 希森美康株式会社 血细胞分析仪、体液分析方法及其控制系统
CN106133145A (zh) * 2014-02-28 2016-11-16 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
CN107406890A (zh) * 2015-02-10 2017-11-28 亿明达股份有限公司 用于分析细胞组分的方法和组合物
CN109402240A (zh) * 2019-01-08 2019-03-01 湖南圣湘生物科技有限公司 核酸释放剂、核酸pcr扩增方法和pcr扩增试剂盒
CN110456034A (zh) * 2018-05-07 2019-11-15 上海市第十人民医院 一种循环肿瘤细胞的检测方法
CN116042772A (zh) * 2023-02-10 2023-05-02 上海立闻生物科技有限公司 针对少量来自于新鲜样本的肿瘤细胞全转录组测序的方法和试剂盒

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
AU2003216175A1 (en) 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
AU2003277153A1 (en) 2002-09-27 2004-04-19 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US20050095634A1 (en) * 2003-10-16 2005-05-05 Genomic Health Inc. qRT-PCR assay system for gene expression profiling
US7332597B2 (en) 2004-06-28 2008-02-19 University Of Kentucky Research Foundation Primers and probe to identify mycobacterium tuberculosis complex
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
DE102005013261A1 (de) * 2005-03-22 2006-09-28 Adnagen Ag Reagenz und Verfahren zur Verhinderung der zeitabhängigen Expression in biologischen Zellen
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE102005029808A1 (de) * 2005-06-27 2007-01-04 Siemens Ag Trägermaterial, Verfahren zu seiner Herstellung und Verwendung
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP5435529B2 (ja) 2005-09-02 2014-03-05 東レ株式会社 腎ガン診断、腎ガン患者予後予測のための組成物および方法
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
JP5457673B2 (ja) * 2005-09-20 2014-04-02 ベリデックス・リミテッド・ライアビリティ・カンパニー ユニーク配列のdnaプローブを作製するための方法および組成物、dnaプローブの標識、ならびにこれらプローブの使用
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
JP5025724B2 (ja) * 2006-04-18 2012-09-12 ウェルスタット バイオロジクス コーポレイション 循環腫瘍性細胞からのタンパク質の検出
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
EP2952589B1 (fr) 2008-09-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Diagnostic non invasif d'une aneuploïdie foetale par séquençage
IT1391619B1 (it) * 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
JP5834001B2 (ja) 2009-03-17 2015-12-16 シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ 細胞を分離するためのマイクロ流体デバイス
JP5729904B2 (ja) * 2009-06-02 2015-06-03 キヤノン株式会社 細胞から蛋白質、dna、rnaを調製する方法
JP5686098B2 (ja) * 2009-09-17 2015-03-18 Jsr株式会社 アビジンとビオチン誘導体の解離方法及び解離剤
EP2521778B1 (fr) * 2010-01-04 2014-03-19 QIAGEN Gaithersburg, Inc. Procédés, compositions et kits de récupération des acides nucléiques ou des protéines dans des échantillons de tissus fixés
EP2614160B1 (fr) 2010-09-10 2016-04-06 Bio-Rad Laboratories, Inc. Détection des régions d'interaction de l'arn au sein de l'adn
WO2012112606A1 (fr) 2011-02-15 2012-08-23 Bio-Rad Laboratories, Inc. Détection de méthylation dans une sous-population d'adn génomique
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
WO2013019960A1 (fr) * 2011-08-03 2013-02-07 Bio-Rad Laboratories, Inc. Filtration de petits acides nucléiques à l'aide de cellules perméabilisées
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
WO2014067528A1 (fr) * 2012-10-29 2014-05-08 Arcedi Biotech Aps Enrichissement et détection améliorés de cellules sanguines rares
US9857361B2 (en) 2013-03-15 2018-01-02 Iris International, Inc. Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
US9771572B2 (en) 2014-02-28 2017-09-26 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
US9771571B2 (en) 2014-02-28 2017-09-26 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
JP2014158468A (ja) * 2014-03-05 2014-09-04 Clinical Genomics Pty Ltd 検出方法
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
WO2023080601A1 (fr) * 2021-11-05 2023-05-11 고려대학교 세종산학협력단 Procédé et dispositif de diagnostic de maladie faisant appel à une technologie d'imagerie par ombre sans lentille basée sur l'apprentissage machine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929556A (en) * 1986-02-06 1990-05-29 The Dow Chemical Company Enzyme immobilization with polysulfonium salts
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
US5882864A (en) * 1995-07-31 1999-03-16 Urocor Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
DE69739909D1 (de) * 1996-03-26 2010-07-29 Michael S Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US6156564A (en) * 1996-06-07 2000-12-05 The United States Of America As Represented By The Department Of Health And Human Services Cellular apoptosis susceptibility protein (CSP) and antisense CSP
WO1999041613A1 (fr) * 1998-02-12 1999-08-19 Immunivest Methodes et reactifs pour l'isolation rapide et efficace de cellules cancereuses circulantes
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
US6358697B2 (en) * 1999-04-21 2002-03-19 Children's Hospital Medical Center Intracellular pharmaceutical targeting

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105807038A (zh) * 2007-02-01 2016-07-27 希森美康株式会社 血细胞分析仪、体液分析方法及其控制系统
CN102565404A (zh) * 2010-12-24 2012-07-11 牛刚 一种检测血液中游离大肠癌细胞标志物的试剂盒
CN102565404B (zh) * 2010-12-24 2014-04-16 牛刚 一种检测血液中游离大肠癌细胞标志物的试剂盒
CN102156164A (zh) * 2011-01-13 2011-08-17 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN102156164B (zh) * 2011-01-13 2012-12-12 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN102109525B (zh) * 2011-01-26 2013-10-16 牛刚 一种检测血液中游离乳腺癌细胞标志物的试剂盒
CN102109525A (zh) * 2011-01-26 2011-06-29 牛刚 一种检测血液中游离乳腺癌细胞标志物的试剂盒
CN105102960B (zh) * 2013-03-15 2017-12-29 艾瑞思国际股份有限公司 用于对尿液样品进行染色和处理的方法和组合物
CN105102960A (zh) * 2013-03-15 2015-11-25 艾瑞思国际股份有限公司 用于对尿液样品进行染色和处理的方法和组合物
US9939356B2 (en) 2013-03-15 2018-04-10 Iris International, Inc. Method and composition for staining and processing a urine sample
CN106133145A (zh) * 2014-02-28 2016-11-16 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
CN106133145B (zh) * 2014-02-28 2020-04-14 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
CN111484992A (zh) * 2014-02-28 2020-08-04 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
CN111484992B (zh) * 2014-02-28 2024-04-02 简·探针公司 从含有甲醛的液基细胞学防腐剂中的样本分离核酸的方法
CN107406890A (zh) * 2015-02-10 2017-11-28 亿明达股份有限公司 用于分析细胞组分的方法和组合物
CN107406890B (zh) * 2015-02-10 2023-07-18 亿明达股份有限公司 用于分析细胞组分的方法和组合物
CN110456034A (zh) * 2018-05-07 2019-11-15 上海市第十人民医院 一种循环肿瘤细胞的检测方法
CN110456034B (zh) * 2018-05-07 2022-07-22 上海市第十人民医院 一种循环肿瘤细胞的检测方法
CN109402240A (zh) * 2019-01-08 2019-03-01 湖南圣湘生物科技有限公司 核酸释放剂、核酸pcr扩增方法和pcr扩增试剂盒
CN116042772A (zh) * 2023-02-10 2023-05-02 上海立闻生物科技有限公司 针对少量来自于新鲜样本的肿瘤细胞全转录组测序的方法和试剂盒

Also Published As

Publication number Publication date
CA2465288A1 (fr) 2003-05-01
CA2465274A1 (fr) 2003-05-01
WO2003035895A3 (fr) 2004-01-08
JP2005507997A (ja) 2005-03-24
WO2003035895A2 (fr) 2003-05-01
WO2003035894A8 (fr) 2004-06-03
BR0213520A (pt) 2006-05-23
IL161357A0 (en) 2004-09-27
AU2002360305A1 (en) 2003-05-06
WO2003035894A3 (fr) 2003-12-04
WO2003035894A2 (fr) 2003-05-01
EP1438398A2 (fr) 2004-07-21
EP1438419A2 (fr) 2004-07-21
KR20040047971A (ko) 2004-06-05

Similar Documents

Publication Publication Date Title
CN1610752A (zh) 多参数全面分析核酸以及同样样品上的形态学特征
CN1153064C (zh) 富集稀少细胞的方法
JP7203128B2 (ja) 血液試料中の循環腫瘍細胞のデジタル分析
WO2013190013A1 (fr) Cellules de phénotype hépatocytaire
CN1922332A (zh) 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法
CN1547617A (zh) 肿瘤学药物革新
CN1922304A (zh) 用于检测循环肿瘤和内皮细胞的血液测试样机和方法
EP2389453A1 (fr) Expression de gènes de cellules individuelles pour le diagnostic, le pronostic et l'identification de cibles médicamenteuses
CN1836166A (zh) 在溶解的体样本中检测肿瘤疾病的方法
CN1150433A (zh) 线粒体缺陷相关疾病的诊断,治疗以及细胞和动物模型
CN1674929A (zh) 蛋白激酶Nβ的应用
CN1898395A (zh) 基于引物的核酸的多重扩增的方法和试剂盒
CN101065501A (zh) 确定基因毒性的方法
CN101523211A (zh) 血细胞分离
CN1213407A (zh) 用于确定抗病毒药物敏感性和抗性和筛选抗病毒药物的组合物和方法
CN100494399C (zh) 一种基于dna芯片的基因分型方法及其应用
CN1678911A (zh) 通过检测gpc3诊断癌症的方法
CN1839205A (zh) 用于鉴定、评估、预防和治疗乳腺癌的组合物、试剂盒及方法
CN1688693A (zh) 使用结合mRNA的探针筛选和分离活细胞
CN1680422A (zh) 从细胞和组织中快速提取rna
CN1871517A (zh) 快速有效分离循环癌细胞的方法和试剂
US20130157893A1 (en) Method for predicting therapeutic effect of immunotherapy on cancer patient, and gene set and kit to be used in the method
RU2636220C2 (ru) Обнаружение клеток, полученных из ткани пуповины человека
CN1705746A (zh) 新转移因子及其应用
CN1721529A (zh) 捕获载体及用该载体进行基因捕获的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication