JP2005507997A - 同一試料についての包括的核酸および形態学的特徴のマルチパラメーター分析 - Google Patents

同一試料についての包括的核酸および形態学的特徴のマルチパラメーター分析 Download PDF

Info

Publication number
JP2005507997A
JP2005507997A JP2003538395A JP2003538395A JP2005507997A JP 2005507997 A JP2005507997 A JP 2005507997A JP 2003538395 A JP2003538395 A JP 2003538395A JP 2003538395 A JP2003538395 A JP 2003538395A JP 2005507997 A JP2005507997 A JP 2005507997A
Authority
JP
Japan
Prior art keywords
cell
rna
group
cancer
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2003538395A
Other languages
English (en)
Japanese (ja)
Inventor
ショーン・マーク・オハラ
ダニエル・ズウェイツィグ
ブラッド・フォーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp filed Critical Immunivest Corp
Publication of JP2005507997A publication Critical patent/JP2005507997A/ja
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003538395A 2001-10-26 2002-10-28 同一試料についての包括的核酸および形態学的特徴のマルチパラメーター分析 Ceased JP2005507997A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33066901P 2001-10-26 2001-10-26
US36994502P 2002-04-04 2002-04-04
PCT/US2002/034570 WO2003035895A2 (fr) 2001-10-26 2002-10-28 Analyse a parametres multiples d'acides nucleiques complets et de caracteristiques morphologiques sur le meme echantillon

Publications (1)

Publication Number Publication Date
JP2005507997A true JP2005507997A (ja) 2005-03-24

Family

ID=26987390

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003538395A Ceased JP2005507997A (ja) 2001-10-26 2002-10-28 同一試料についての包括的核酸および形態学的特徴のマルチパラメーター分析

Country Status (9)

Country Link
EP (2) EP1438419A2 (fr)
JP (1) JP2005507997A (fr)
KR (1) KR20040047971A (fr)
CN (1) CN1610752A (fr)
AU (1) AU2002360305A1 (fr)
BR (1) BR0213520A (fr)
CA (2) CA2465288A1 (fr)
IL (1) IL161357A0 (fr)
WO (2) WO2003035894A2 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534667A (ja) * 2006-04-18 2009-09-24 ウェルスタット バイオロジックス コーポレイション 循環腫瘍性細胞からのタンパク質の検出
EP2154245A2 (fr) 2005-09-02 2010-02-17 Toray Industries, Inc. Composition et procédé pour le diagnostic du cancer du rein et pour prédire le pronostic d'un patient atteint de cancer du rein
WO2011034115A1 (fr) * 2009-09-17 2011-03-24 Jsr株式会社 Procédé de dissociation et agent de dissociation pour avidine et biotine
JP2012507733A (ja) * 2008-11-04 2012-03-29 シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ 腫瘍細胞を同定、選択及び解析する方法
JP2012175976A (ja) * 2005-09-20 2012-09-13 Veridex Llc ユニーク配列のｄｎａプローブを作製するための方法および組成物、ｄｎａプローブの標識、ならびにこれらプローブの使用
JP2013516183A (ja) * 2010-01-04 2013-05-13 キアジェン ゲイサーズバーグ インコーポレイテッド 固定された組織サンプルからの核酸またはタンパク質の回収のための方法、組成物、およびキット
US8679856B2 (en) 2006-03-27 2014-03-25 Silicon Biosystems S.P.A. Method and apparatus for the processing and/or analysis and/or selection of particles, in particular biological particles
US8679315B2 (en) 2005-10-26 2014-03-25 Silicon Biosystems S.P.A. Method and apparatus for characterizing and counting particles, in particular, biological particles
US8685217B2 (en) 2004-07-07 2014-04-01 Silicon Biosystems S.P.A. Method and apparatus for the separation and quantification of particles
JP2014158468A (ja) * 2014-03-05 2014-09-04 Clinical Genomics Pty Ltd 検出方法
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
US9192943B2 (en) 2009-03-17 2015-11-24 Silicon Biosystems S.P.A. Microfluidic device for isolation of cells
US9310287B2 (en) 2007-10-29 2016-04-12 Silicon Biosystems S.P.A. Method and apparatus for the identification and handling of particles
JP2016512337A (ja) * 2013-03-15 2016-04-25 アイリス インターナショナル， インコーポレイテッド 尿サンプルの染色及び処理のための方法及び組成物
US9719960B2 (en) 2005-07-19 2017-08-01 Menarini Silicon Biosystems S.P.A. Method and apparatus for the manipulation and/or the detection of particles
JP2018021934A (ja) * 2011-04-01 2018-02-08 ヤンセン・ダイアグノスティックス・エルエルシーＪａｎｓｓｅｎ Ｄｉａｇｎｏｓｔｉｃｓ， ＬＬＣ 腫瘍細胞を検出するためのステロイド受容体アッセイ
US10376878B2 (en) 2011-12-28 2019-08-13 Menarini Silicon Biosystems S.P.A. Devices, apparatus, kit and method for treating a biological sample
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
US11921028B2 (en) 2011-10-28 2024-03-05 Menarini Silicon Biosystems S.P.A. Method and device for optical analysis of particles at low temperatures

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US7318902B2 (en) 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
CA2542656A1 (fr) * 2003-10-16 2005-05-06 Genomic Health, Inc. Systeme d'essai qrt-pcr pour le profilage d'expression genetique
US7332597B2 (en) 2004-06-28 2008-02-19 University Of Kentucky Research Foundation Primers and probe to identify mycobacterium tuberculosis complex
DE102005013261A1 (de) * 2005-03-22 2006-09-28 Adnagen Ag Reagenz und Verfahren zur Verhinderung der zeitabhängigen Expression in biologischen Zellen
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE102005029808A1 (de) * 2005-06-27 2007-01-04 Siemens Ag Trägermaterial, Verfahren zu seiner Herstellung und Verwendung
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US8119976B2 (en) 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
WO2007147074A2 (fr) 2006-06-14 2007-12-21 Living Microsystems, Inc. Utilisation de génotypage snp fortement parallèle pour diagnostic fœtal
EP2041299A4 (fr) 2006-07-14 2010-01-13 Aviva Biosciences Corp Procedes et compositions servant a detecter des cellules rares dans un echantillon biologique
JP4926812B2 (ja) * 2007-02-01 2012-05-09 シスメックス株式会社 血球分析装置および体液分析方法
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
LT2334812T (lt) 2008-09-20 2017-04-25 The Board Of Trustees Of The Leland Stanford Junior University Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu
JP5729904B2 (ja) 2009-06-02 2015-06-03 キヤノン株式会社 細胞から蛋白質、ｄｎａ、ｒｎａを調製する方法
US9273347B2 (en) 2010-09-10 2016-03-01 Bio-Rad Laboratories, Inc. Detection of RNA-interacting regions in DNA
CN102565404B (zh) * 2010-12-24 2014-04-16 牛刚 一种检测血液中游离大肠癌细胞标志物的试剂盒
CN102156164B (zh) * 2011-01-13 2012-12-12 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN102109525B (zh) * 2011-01-26 2013-10-16 牛刚 一种检测血液中游离乳腺癌细胞标志物的试剂盒
WO2012112606A1 (fr) 2011-02-15 2012-08-23 Bio-Rad Laboratories, Inc. Détection de méthylation dans une sous-population d'adn génomique
EP2739752B1 (fr) * 2011-08-03 2017-07-19 Bio-Rad Laboratories, Inc. Filtration de petits acides nucléiques à l'aide de cellules perméabilisées
WO2014067528A1 (fr) * 2012-10-29 2014-05-08 Arcedi Biotech Aps Enrichissement et détection améliorés de cellules sanguines rares
US9857361B2 (en) 2013-03-15 2018-01-02 Iris International, Inc. Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
EP3670663A1 (fr) * 2014-02-28 2020-06-24 Gen-Probe Incorporated Procédé pour isoler l'acide nucléique d'échantillons dans des conservateurs de cytologie aqueux contenant du formaldéhyde
US9771571B2 (en) 2014-02-28 2017-09-26 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
US9771572B2 (en) 2014-02-28 2017-09-26 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
KR20170135834A (ko) * 2015-02-10 2017-12-08 일루미나, 인코포레이티드 세포 성분을 분석하기 위한 방법 및 조성물
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
CN110456034B (zh) * 2018-05-07 2022-07-22 上海市第十人民医院 一种循环肿瘤细胞的检测方法
CN109402240B (zh) * 2019-01-08 2020-08-25 圣湘生物科技股份有限公司 核酸释放剂、核酸pcr扩增方法和pcr扩增试剂盒
WO2023080601A1 (fr) * 2021-11-05 2023-05-11 고려대학교 세종산학협력단 Procédé et dispositif de diagnostic de maladie faisant appel à une technologie d'imagerie par ombre sans lentille basée sur l'apprentissage machine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929556A (en) * 1986-02-06 1990-05-29 The Dow Chemical Company Enzyme immobilization with polysulfonium salts
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
CA2262403C (fr) * 1995-07-31 2011-09-20 Urocor, Inc. Biomarqueurs et cibles de diagnostic, de pronostic et de traitement du cancer de la prostate
US6329179B1 (en) * 1996-03-26 2001-12-11 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6156564A (en) * 1996-06-07 2000-12-05 The United States Of America As Represented By The Department Of Health And Human Services Cellular apoptosis susceptibility protein (CSP) and antisense CSP
IL137802A0 (en) * 1998-02-12 2001-10-31 Immunivest Corp A method and kit for detecting rare cells in a mixed cell population
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
US6358697B2 (en) * 1999-04-21 2002-03-19 Children's Hospital Medical Center Intracellular pharmaceutical targeting

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685217B2 (en) 2004-07-07 2014-04-01 Silicon Biosystems S.P.A. Method and apparatus for the separation and quantification of particles
US9719960B2 (en) 2005-07-19 2017-08-01 Menarini Silicon Biosystems S.P.A. Method and apparatus for the manipulation and/or the detection of particles
EP2154245A2 (fr) 2005-09-02 2010-02-17 Toray Industries, Inc. Composition et procédé pour le diagnostic du cancer du rein et pour prédire le pronostic d'un patient atteint de cancer du rein
EP2404998A2 (fr) 2005-09-02 2012-01-11 Kyoto University Composition et procédé pour le diagnostic du cancer du rein et pour prédire le pronostic d'un patient atteint de cancer du rein
US11015227B2 (en) 2005-09-20 2021-05-25 Menarini Silicon Biosystems S.P.A. Methods and compositions to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
US9957571B2 (en) 2005-09-20 2018-05-01 Menarini Silicon Biosystems, Inc. Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
JP2012175976A (ja) * 2005-09-20 2012-09-13 Veridex Llc ユニーク配列のｄｎａプローブを作製するための方法および組成物、ｄｎａプローブの標識、ならびにこれらプローブの使用
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
US9127302B2 (en) 2005-09-20 2015-09-08 Janssen Diagnostics, Llc System for the detection and enumeration of suspect target cells in a mixed cell population
US8992754B2 (en) 2005-10-26 2015-03-31 Silicon Biosystems S.P.A. Method and apparatus for the characterizing and counting particles, in particular, biological particles
US8679315B2 (en) 2005-10-26 2014-03-25 Silicon Biosystems S.P.A. Method and apparatus for characterizing and counting particles, in particular, biological particles
US9581528B2 (en) 2006-03-27 2017-02-28 Menarini Silicon Biosystems S.P.A. Method and apparatus for the processing and/or analysis and/or selection of particles, in particular, biological particles
US8679856B2 (en) 2006-03-27 2014-03-25 Silicon Biosystems S.P.A. Method and apparatus for the processing and/or analysis and/or selection of particles, in particular biological particles
US10092904B2 (en) 2006-03-27 2018-10-09 Menarini Silicon Biosystems S.P.A. Method and apparatus for the processing and/or analysis and/or selection of particles, in particular biological particles
JP2009534667A (ja) * 2006-04-18 2009-09-24 ウェルスタット バイオロジックス コーポレイション 循環腫瘍性細胞からのタンパク質の検出
US9310287B2 (en) 2007-10-29 2016-04-12 Silicon Biosystems S.P.A. Method and apparatus for the identification and handling of particles
US10648897B2 (en) 2007-10-29 2020-05-12 Menarini Silicon Biosystems S.P.A. Method and apparatus for the identification and handling of particles
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
US10234447B2 (en) 2008-11-04 2019-03-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
JP2012507733A (ja) * 2008-11-04 2012-03-29 シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ 腫瘍細胞を同定、選択及び解析する方法
US9192943B2 (en) 2009-03-17 2015-11-24 Silicon Biosystems S.P.A. Microfluidic device for isolation of cells
JP5686098B2 (ja) * 2009-09-17 2015-03-18 Jsr株式会社 アビジンとビオチン誘導体の解離方法及び解離剤
JPWO2011034115A1 (ja) * 2009-09-17 2013-02-14 Jsr株式会社 アビジンとビオチン誘導体の解離方法及び解離剤
US8685655B2 (en) 2009-09-17 2014-04-01 Jsr Corporation Dissociation method and dissociation agent for avidin and biotin derivatives
WO2011034115A1 (fr) * 2009-09-17 2011-03-24 Jsr株式会社 Procédé de dissociation et agent de dissociation pour avidine et biotine
JP2013516183A (ja) * 2010-01-04 2013-05-13 キアジェン ゲイサーズバーグ インコーポレイテッド 固定された組織サンプルからの核酸またはタンパク質の回収のための方法、組成物、およびキット
JP2018021934A (ja) * 2011-04-01 2018-02-08 ヤンセン・ダイアグノスティックス・エルエルシーＪａｎｓｓｅｎ Ｄｉａｇｎｏｓｔｉｃｓ， ＬＬＣ 腫瘍細胞を検出するためのステロイド受容体アッセイ
US11921028B2 (en) 2011-10-28 2024-03-05 Menarini Silicon Biosystems S.P.A. Method and device for optical analysis of particles at low temperatures
US10376878B2 (en) 2011-12-28 2019-08-13 Menarini Silicon Biosystems S.P.A. Devices, apparatus, kit and method for treating a biological sample
JP2016512337A (ja) * 2013-03-15 2016-04-25 アイリス インターナショナル， インコーポレイテッド 尿サンプルの染色及び処理のための方法及び組成物
JP2014158468A (ja) * 2014-03-05 2014-09-04 Clinical Genomics Pty Ltd 検出方法

Also Published As

Publication number Publication date
WO2003035894A3 (fr) 2003-12-04
KR20040047971A (ko) 2004-06-05
WO2003035894A2 (fr) 2003-05-01
WO2003035895A2 (fr) 2003-05-01
CN1610752A (zh) 2005-04-27
WO2003035895A3 (fr) 2004-01-08
EP1438419A2 (fr) 2004-07-21
IL161357A0 (en) 2004-09-27
BR0213520A (pt) 2006-05-23
CA2465274A1 (fr) 2003-05-01
CA2465288A1 (fr) 2003-05-01
AU2002360305A1 (en) 2003-05-06
EP1438398A2 (fr) 2004-07-21
WO2003035894A8 (fr) 2004-06-03

Similar Documents

Publication Publication Date Title
JP2005507997A (ja) 同一試料についての包括的核酸および形態学的特徴のマルチパラメーター分析
US20060008807A1 (en) Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
Bryzgunova et al. Comparative study of extracellular vesicles from the urine of healthy individuals and prostate cancer patients
JP7094880B2 (ja) 代表診断法
EP2258872B1 (fr) Profilage de l'expression génétique dans des tissus de tumeurs prélevées par biopsie
CN109777872B (zh) 肺癌中的t细胞亚群及其特征基因
JP5763545B2 (ja) ホルマリン固定組織からの種々の生体分子の並行抽出
EP2638176B1 (fr) Enrichissement et identification de cellules foetales dans le sang maternel et ligands pour cette utilisation
Mathieson et al. A critical evaluation of the PAXgene tissue fixation system: morphology, immunohistochemistry, molecular biology, and proteomics
CA2620528A1 (fr) Procedes et compositions permettant d'identifier des biomarqueurs utiles au diagnostic et/ou au traitement d'etats biologiques
EP3543359A1 (fr) Marqueur moléculaire, kit et application destinés à être utilisés dans le diagnostic précoce et la prédiction d'une septicémie en tant que complication d'une lésion rénale aiguë
Jacobson et al. Gene expression analysis using long-term preserved formalin-fixed and paraffin-embedded tissue of non-small cell lung cancer
US20180128832A1 (en) Proteogenomic analysis system and methods
EP3358020A2 (fr) Système de test de diagnostic pour détection spécifique, sensible et reproductible d'acides nucléiques en circulation dans le sang total
Pinzani et al. Circulating cell-free DNA in cancer
KR100873629B1 (ko) 신규한 폐암 진단용 마커
US20100323354A1 (en) Means and methods for the detection and isolation of fetal and embryonic cells and nucleic acid from maternal body fluid
AU2002360316A1 (en) Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
Kobayashi et al. One-step RT-PCR without initial RNA isolation step for laser-microdissected tissue sample
KR102350228B1 (ko) 신장이식 후 t세포 매개성 거부반응의 진단 또는 예측을 위한 소변 엑소좀 바이오마커
Van Langendonckt et al. Identification of novel antigens in blood vessels in rectovaginal endometriosis
Lin High-Throughput Microfluidic Platform for Ultrasensitive Single-Cell Protein Analyses
WO2011084485A1 (fr) Isolement d'arnm activement traduits d'un petit nombre de cellules
Lin et al. Application of molecular biology to impotence research

Legal Events

Date Code Title Description
A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A043

Effective date: 20050927