CN1583179A - Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation - Google Patents

Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation Download PDF

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CN1583179A
CN1583179A CN 03130584 CN03130584A CN1583179A CN 1583179 A CN1583179 A CN 1583179A CN 03130584 CN03130584 CN 03130584 CN 03130584 A CN03130584 A CN 03130584A CN 1583179 A CN1583179 A CN 1583179A
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medicinal
liquid
alcohol
medical material
chinese medicine
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CN1285385C (en
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张铁军
许浚
龚苏晓
薛艳
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Tianjin Institute of Pharmaceutical Research Co Ltd
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Tianjin Institute of Pharmaceutical Research Co Ltd
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Abstract

An antiviral Chinese-medicinal bactericide in the form of spray for refreshing air and killing the pathogenic ricrobes is prepared from 7 Chinese-medicinal materials including honeysuckle flower, agastache, pine needle, cloves, etc through decocting, adding alcohol, depositing to remove impurities and loading in sprayer.

Description

A kind of pure Chinese medicine anti-virus sterilizing spray and preparation method thereof
Technical field:
The present invention relates to a kind of anti-virus sterilizing spray and preparation method thereof.Particularly a kind of pure Chinese medicine anti-virus sterilizing spray and preparation method thereof.
Background technology:
In our living space, often have pathogenic microorganism, or float in air with the form of dust, the spittle or droplet nuclel attached on people's medicated clothing, body surface, the furniture.When people pass through to breathe, contact or sucked these pathogenic microorganisms, then can cause disease.The kind of pathogenic microorganism is a lot, has bacteroidal, fungoid, viral or the like.Common viral disease, as influenza, herpes, encephalitis b, hepatitis etc., particularly during year spring winter to 2003 in 2002, the severe acute respiratory syndrome in whole world outburst all causes serious harm to human beings'health.
Along with the continuous development of science and technology, the disease of antibacterial, virus type can prevented at present, and wherein the most direct, effective method is killed the pathogenic microorganism (pathogenic bacterium or virus) in body surface, air and the environment exactly, and the people is avoided infection.As the infectious atypical pneumonia burst period, use disinfectant to carry out sterilization, prevented that epidemic situation from spreading, the effect of played effective prevention, protecting from infection.
At present, be used for the spraying sterilizing agent of air and environment,, also have certain defective though have certain antibiotic and sterilizing effect; With the peracetic acid is example, and this product uses the most extensive in the propagation of resisting infectious atypical pneumonia, though the effect of kill bacteria, virus is arranged, and still, at first it has a kind of unpleasant tart flavour, not only influence beautifying of environment space, also influential to people's pleasure; The second, eye, nasal cavity and the respiratory mucosa of human body there is zest, often use to produce " peracetic acid syndrome "; The 3rd, skin, direct medicated clothing, furniture and other organic material material that contacts there are certain corrosivity, the mottling that stays is difficult to remove.
In view of above defective, this series products the particular time of viral disease outburst use still can, but after the high-incidence season, then be not well suited for as the disinfectant of daily antibiotic and sterilizing, fresh air.
See again and be used to the spray for refreshing air that purifies air at present, patent of invention as CN1088557C, CN1097452C mandate, it is formulated how to be equipped with synthetic perfume by chemical substance, the disclosed a kind of aerosol disinfectant of CN1398519A in addition, it is to be primary raw material with 84 disinfectant solution, be equipped with suitable other chemical substances such as essence and make, all contain chemical oxidizing agent, have certain corrosiveness.And these air fresheners are to be unique function with simple deodorization, flavouring, fresh air, itself do not have the effect of resisting pathogenic microbes, can not prevent disease, therefore, also there is defective on the function of product.
Summary of the invention:
The present invention aims to provide a kind of pure Chinese medicine anti-virus sterilizing spray and preparation method thereof, but both fresh air of this pure Chinese medicine anti-virus sterilizing spray can suppress or kill pathogenic microbes such as body surface, article and airborne antibacterial, virus again.
Concrete technical scheme is as follows:
A kind of pure Chinese medicine anti-virus sterilizing spray, it is made up of Flos Lonicerae, Herba Pogostemonis, Folium Pini, Herba Lysimachiae foenum-graeci, Herba Eupatorii, Flos Caryophylli, Cacumen Platycladi and medicinal alcohol, and its preparation method comprises the following steps:
(1) prescription: with following medical material according to weight ratio;
1~10 part of Flos Lonicerae,
1~10 part of Herba Pogostemonis,
1~10 part of Folium Pini,
1~10 part of Herba Lysimachiae foenum-graeci,
1~10 part of Herba Eupatorii,
1~10 part of Flos Caryophylli,
1~10 part of Cacumen Platycladi,
(2) preparation technology: after above medical material mixed, water decocted also and extracts 1~3 time, collects volatile oil and decocting liquid; Add ethanol to decocting liquid and contain amount of alcohol for (50~80) %, the precipitation removal of impurity obtains medicinal liquid after the filtration; Add volatile oil in medicinal liquid, the alcohol amount that contains that reuse medicinal alcohol and water transfer to medicinal liquid is (50~80) %, and containing the medical material amount is 4-10%, is product of the present invention, and being filled into aerosol can use.
Wherein, the decocting method boiling and extract is
In the medical material mixture, add and be equivalent to mix the water of 6~15 times of medical material weight, boil and extract 1-3 time, each 1-5 hour, collect its volatile oil and decocting liquid.
The present invention is based on antibacterial and virus type disease and be that infection owing to pathogenic microorganism causes, the understanding of paathogenic factor and the traditional Chinese medical science is for the theory of the cause of disease of " epidemic febrile disease ", pathogenesis, the rule of treatment, according to the demand of people, carry out rational formula and develop again the deodorization of air freshener, flavouring, fresh air.
The traditional Chinese medical science thinks that the virus type disease belongs to " epidemic febrile disease " category, and its cause of disease is many owing to human righteousness's deficiency in origin, and exopathogen is easily invaded; Or the excess pathogen internal memory, tie mutually with the warm heresy in outside again, retention of damp-heat in the interior, for disease for suffering from.Pathogenesis mostly is the invasion of pathogenic wind-warm, hygropyrexia epidemic disease poison, attacking the lung first, and mechanism of qi is obstructed, lifting mistake department, heresy is not passed through inside, clear YANG failing to ascend in the body, turbid YIN failing to descend accumulates in warm, and the exopathogen invading the interior heat-transformation is damp and hotly tied mutually, burns in the evil poison.Explain that with modern medicine promptly virus is invaded pulmonary by respiratory tract, duplicates, transcribes in host cell, cause cell injury, disturb immunologic function.Cell produces inflammatory reaction and discharges inflammatory mediator, forming pulmonary soaks into and fibrosis lesion, influence lung functions, the invasion of virus simultaneously destroys the immunologic balance of pulmonary and even health, premunition weakens, and forms the secondary infection of antibacterial and virus, heat production in vivo such as viral and bacteriogenic endotoxin and inflammatory mediator, cytokine, the heating of patient's hyperpyrexia further increases the weight of the state of an illness.
Based on as above being familiar with, the present invention improves body resistance against diseases and starts with from prevent disease.At first, the generation of such disease is how relevant with domination of pathogen internal memory, and interior foreign minister's knot has strengthened the susceptibility of disease, and interior heresy mostly is damp and hot, the functional activity of QI being not smooth of plain body, in case the contact outside virus, then the infection for virus provides perfect breeding environment, promptly interior foreign minister's knot.And because functional activity of QI being not smooth, heresy is not passed through inside, heat-transformation in easily going into.Therefore, the present invention adopts heat-clearing and toxic substances removing, repelling foulness with aromatics, the removing dampness of being amusing, and declares the Chinese medicine of smooth mechanism of qi, sucks by respiratory tract, plays and removes the effect that excess pathogen, clearing heat and eliminating dampness, bar in the body reach lung qi, can improve the functional status of body, improves the antiviral infection ability.
Antibacterial and virus type disease have very strong infectiousness, often be known as epidemic disease, eqpidemic disease, pestilence, lid is because its cause of disease is pathogenic microorganism (antibacterial, a virus etc.), can pass through propagation such as saliva, blood, feces, insect vector, can survive in body surface and air, infect and cause a disease, generally exist with three kinds of forms in air: (1) is attached on the dust; (2) on the spittle droplet attached to nasal cavity or oral cavity ejection; (3) attached on the formed droplet nuclel after the spittle surface evaporation.Therefore, sterilization, Bactericidal medicine can kill, suppress breeding effectively after spraying in air, reduce pathogenicity.
The present invention adopts Flos Caryophylli, Flos Lonicerae, Herba Taraxaci, Rhizoma Osmundae, Folium Pini heat-clearing and toxic substances removing, and dispelling wind and heat pathogens has antibiotic, antiviral effect.Wherein,
Flos Lonicerae is the alabastrum of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica.Effect with heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Be used for affection due to external wind and heat, epidemic febrile disease from the beginning of diseases such as, respiratory tract infection, the swollen furunculosis of skin ulcer, diarrhoea, dysentery, parotitiss, " wind-fire is damp and hot in the clear network, separates the dirty filthy heresy of pestilence for " Chongqing hall random notes " speech." often do tea-drinking and use.Pharmacological research shows, Flos Lonicerae has broad spectrum antibacterial function, and staphylococcus aureus, Hemolytic streptococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, bordetella pertussis, tubercule bacillus, Diplococcus pneumoniae, meningococcus, vibrio cholera etc. are all had inhibitory action.Flos Lonicerae also has antivirus action, can delay the pathological changes effect of Respirovirus pair cell.Influenza virus, Orphan virus, herpesvirus etc. all there are inhibitory action, can suppress duplicating of virus, delay the generation of viral pair cell pathological changes, COxsackie and echovirus are had very strong inhibitory action.
Herba Pogostemonis is the dry aerial parts of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth..Have removing dampness by means of aromatics, deliver the effect of expelling summer-heat and middle preventing or arresting vomiting.Its hot temperature fragrance both can have been opened the flesh natural fibre line of meat, saturating hair key, the pathogenic factor in the exterior that looses, but again removing dampness turbid, ward off dirty evil.For diseases caused by exogenous pathogenic factor and heat-damp in summer, hygropyrexia from the beginning of, wind pestilence miasma all available it.That Herba Pogostemonis has is antibiotic, antiviral, antiinflammatory, improves the effect of gastrointestinal function, is " heat-damp in summer " medication of using always, but also is edible medicine raw material.
Herba Eupatorii is the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Because of fragrance such as orchid, the heresy of driving away summer heat of pendant is warded off oxious gas, so name.Its function can be summarized as expelling summer-heat, removing dampness, it is dirty to ward off.Because of its abnormal smells from the patient delicate fragrance, external enwergy opens the flesh natural fibre line of meat, saturating hair key, it is wet to drive away summer heat; Internal energy ward off foul, remove bad odor, the removing dampness of being amusing.So for diseases caused by exogenous pathogenic factor heat-damp in summer, hygropyrexia from the beginning of etc. disease just be its usefulness.Herba Eupatorii all has inhibitory action to diphtheria corynebacterium, staphylococcus aureus, sarcina, Bacillus proteus, Bacillus typhi, dysentery bacterium etc., and influenza virus is had inhibitory action.
Flos Caryophylli is the dry flower of plant clove of myrtaceae Eugenia caryophyllata Thumb..Fragrant odour all has inhibitory action to bacillus pestis, vibrio cholera, anthrax bacillus, Bacillus typhi, Salmonella paratyphi, diphtheria corynebacterium, dysentery bacterium, Bacillus proteus, escherichia coli, bacillus subtilis, staphylococcus aureus, Brucella, black type tubercule bacillus, starlike two card Salmonellas, achorion schoenleinii, microsporon gypseum, epidermophyton inguinale, Candida albicans etc.
Folium Pini is the leaf of pinaceae plant Pinus massoniana Lamb Pinus massoniana Lamb., has dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching.Be used for various wet bleb tinea scabies, and can prevent and treat epidemic encephalitis, influenza.
Herba Lysimachiae foenum-graeci and Cacumen Platycladi also have bactericidal action, and the energy flavouring, fresh air.
More than each raw material shared, can ward off dirty dehumidifying, clearing summer heat, inhibition antibacterial and virus, the prevention relevant disease generation.
Above-mentioned medical material has antibiotic and antivirus action through extracting each effective ingredient after the mixing, influenza virus, adenovirus, Orphan virus, epidemic encephalitis virus, herpesvirus, Coxsackie virus, Echovirus etc. are all had stronger inhibitory action.Funguses such as antibacterials such as staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, bacillus subtilis, dysentery bacterium, diphtheria corynebacterium, Bacillus proteus, escherichia coli, bacillus pestis, vibrio cholera, anthrax bacillus and achorion schoenleinii, the little spore bacterium of Gypsum Fibrosum sample, epidermophyton inguinale, Candida albicans all there is bacteriostasis.
Experimental results show that: product of the present invention all has bacteriostasis to gram positive bacteria and gram negative bacteria, to skin, mucosa is non-stimulated and corrosiveness.
The fungistatic effect and the data of safety of product of the present invention are as follows:
1, product of the present invention is to aureus with inhibition;
Drug level The experiment sequence number Inhibition zone diameter (mm)
????1 ????2 ????3 ????4 Meansigma methods Negative control
Stock solution ????1 ????7.5 ????7.5 ????8 ????7.5 ????7.6 ????<7
????2 ????8 ????8 ????7.5 ????7.5 ????7.8 ????<7
????3 ????8 ????8 ????7.5 ????8 ????7.9 ????<7
2, product of the present invention is to the effect of Candida albicans growth inhibited;
Drug level The experiment sequence number Inhibition zone diameter (mm)
????1 ????2 ????3 ????4 Meansigma methods Negative control
Stock solution ????1 ????8 ????8 ????8 ????8 ????8 ????<7
????2 ????8.2 ????8.2 ????8 ????8 ????8.1 ????<7
????3 ????8 ????8 ????8.5 ????8.5 ????8.25 ????<7
3, product of the present invention is to Japan large ear rabbit acute skin irritation experimental result;
Number of animals Sex Body weight kg ???????????????1h ???????????????48h ???????????????72h
Sample Contrast Sample Contrast Sample Contrast
Erythema Edema Total points Erythema Edema Total points Erythema Edema Total points Erythema Edema Total points Erythema Edema Total points Erythema Edema Total points
1 Female 25 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0
2 Female 26 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0
3 Female 26 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0
4 Female 25 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0
Integral mean value ????????0 ????????0 ????????0 ????????0 ????????0 ????????0
The stimulus intensity classification Nonirritant
Annotate: 1. integral mean value is the integration of the irritant reaction of average every animal.The stimulus intensity evaluation with 24,48 and 72h in the top average, determine by table 2~12 in " disinfection technology standard " (version in 2002) skin irritation test.
4. product of the present invention is tested acute oral toxicity;
The animal sex Dosage (g/kg) Number of animals (only) Body weight (g) Dead animal number (only) Mortality rate (%)
First First week Second week
??5 10 ?20.1±1.0 ?25.1±1.0 ?30.7±1.3 0 0
??5 10 ?19.3±0.6 ?24.3±0.7 ?29.6±0.9 0 0
Experimental session, animal subject are not seen tangible poisoning manifestations, do not have death, and each main organs also shows no obvious abnormalities in the postmortem.
5. product of the present invention is tested the acute toxicity on inhalation of mice,
The animal sex Dosage (g/kg) Number of animals (only) Body weight (g) Dead animal number (only) Mortality rate (%)
First First week Second week
??♂ ??10000 ??10 ?20.1±0.9 ?25.1±0.8 ?30.5±1.2 0 ????0
??♀ ??10000 ??10 ?19.4±0.6 ?24.4±0.7 ?29.4±0.8 0 ????0
Experimental session, animal subject are not seen tangible poisoning manifestations, also no abnormality seen of main organs in the postmortem.
Product of the present invention has following characteristics:
1, integrate the function of sterilization, sterilization and fresh air.
2, integrate and suppress or kill the pathogenic microorganism (antibacterial or fungus, virus) in the environment and improve the human body internal milieu and functional status, enhancing resistance against diseases, reach the inside and outside dual protective effect.
3, the natural plants essence, fragrance is true, and does not have the toxic and side effects of chemically composite perfume, and is free from environmental pollution.
Spray of the present invention can suck the interior environment that improves human body by respiratory tract, strengthens antiviral ability; Especially adopt the natural Chinese medicines composition, do not have any chemically composite perfume, free from environmental pollution, can remove smell, flavouring, fresh air.Being specially adapted to individual, room and working space uses.
The specific embodiment;
Embodiment 1:
(1) batching:, following Chinese medicine medical material is mixed according to weight ratio;
Flos Lonicerae: 2 parts of 10g
Herba Pogostemonis: 1 part of 5g
Herba Lysimachiae foenum-graeci: 1 part of 5g
Herba Eupatorii: 1 part of 5g
Flos Caryophylli: 1 part of 5g
Folium Pini: 1 part of 5g
Cacumen Platycladi: 1 part of 5g
(2) preparation technology;
(1) with above Chinese medicine medical material mixture, add the water of 10 times of weight of mixing medical material, boiled 5 hours, and extract volatile oil and decocting liquid, decocting liquid is filtered, obtain medicinal liquid and medicinal residues;
(2) in the gained medicinal residues, add the water of 6 times of weight of mixing medical material, extract decocting liquid, decocting liquid is filtered the back taking liquid in the back of boiling;
(3) merge twice medicinal liquid, be concentrated into relative density 1.15, add 95% medicinal alcohol, make medicinal liquid contain amount of alcohol and reach 70%, left standstill filtering extracting liquid 24 hours;
(4) medicinal liquid is mixed with volatile oil, add medicinal alcohol and water, making that to contain amount of alcohol in the medicinal liquid be 70%, contain raw medicinal material concentration is 4%, and being filled into aerosol can use.
Embodiment 2:
(1) batching:, following raw material of Chinese medicine is mixed according to weight ratio;
Flos Lonicerae: 2 parts of 10g
Herba Pogostemonis: 1 part of 5g
Herba Lysimachiae foenum-graeci: 2 parts of 10g
Herba Eupatorii: 1 part of 5g
Flos Caryophylli: 1 part of 5g
Folium Pini: 2 parts of 10g
Cacumen Platycladi: 2 parts of 10g
(2) preparation technology;
(1) above medical material mixture is added 10 times of weight water that mix medical material, boiled 5 hours, and extract volatile oil and decocting liquid, decocting liquid is filtered, obtain medicinal liquid and medicinal residues;
(2) adding mixes the water of 6 times of weight of medical material in the medicinal residues, extracts decocting liquid in the back of boiling, taking liquid after decocting liquid is filtered;
(3) merge twice medicinal liquid, be concentrated into relative density 1.15, use medicinal ethanol precipitation, make medicinal liquid contain amount of alcohol and reach 70%, left standstill filtering extracting liquid 24 hours;
(4) medicinal liquid is mixed with volatile oil, add medicinal alcohol and water, transferring to this medicinal liquid, to contain amount of alcohol be 70%, and containing raw medicinal material concentration is 6%, and being filled into aerosol can use.

Claims (3)

1, a kind of pure Chinese medicine anti-virus sterilizing spray and preparation method thereof is characterized in that: it is made up of Flos Lonicerae, Herba Pogostemonis, Folium Pini, Herba Lysimachiae foenum-graeci, Herba Eupatorii, Flos Caryophylli, Cacumen Platycladi and medicinal alcohol; Its prescription consists of: according to weight ratio, following Chinese medicine medical material is mixed;
1~10 part of Flos Lonicerae,
1~10 part of Herba Pogostemonis,
1~10 part of Folium Pini,
1~10 part of Herba Lysimachiae foenum-graeci,
1~10 part of Herba Eupatorii,
1~10 part of Flos Caryophylli,
1~10 part of Cacumen Platycladi,
Preparation technology is:
Above medical material mixture water is decocted and extracts 1~3 time, collect volatile oil and decocting liquid; Add ethanol to decocting liquid and contain amount of alcohol for (50~80) %, the precipitation removal of impurity obtains medicinal liquid after the filtration, add volatile oil in the medicinal liquid, and the alcohol amount that contains that reuse medicinal alcohol and water transfer to medicinal liquid is (50~80) %, and containing the medical material amount is 4-10%.
2, according to described pure Chinese medicine anti-virus sterilizing spray of claim 1 and preparation method thereof, it is characterized in that:
Its prescription consists of: according to weight ratio, following Chinese medicine medical material is mixed;
Flos Lonicerae: 2 parts of 10g
Herba Pogostemonis: 1 part of 5g
Herba Lysimachiae foenum-graeci: 1 part of 5g
Herba Eupatorii: 1 part of 5g
Flos Caryophylli: 1 part of 5g
Folium Pini: 1 part of 5g
Cacumen Platycladi: 1 part of 5g
Preparation technology is:
To add 10 times of weight water that mix medical material according to the blended Chinese medicine medical material of above weight ratio, boil 5 hours, and extract volatile oil and decocting liquid, decocting liquid will be filtered, obtain medicinal liquid and medicinal residues; In the gained medicinal residues, add the water of 6 times of weight of mixing medical material, extract decocting liquid in the back of boiling, decocting liquid is filtered the back taking liquid; Merge medicinal liquid twice, be concentrated into relative density 1.15, add 95% medicinal alcohol, make medicinal liquid contain amount of alcohol and reach 70%, static 24 hours, filtering extracting liquid; Medicinal liquid is mixed with volatile oil, add medicinal alcohol and water, making that to contain amount of alcohol in the medicinal liquid be 70%, contain raw medicinal material concentration is 4%.
3, according to described pure Chinese medicine anti-virus sterilizing spray of claim 1 and preparation method thereof, it is characterized in that:
Its prescription consists of;
According to weight ratio, following Chinese medicine medical material is mixed;
Flos Lonicerae: 2 parts of 10g
Herba Pogostemonis: 1 part of 5g
Herba Lysimachiae foenum-graeci: 2 parts of 10g
Herba Eupatorii: 1 part of 5g
Flos Caryophylli: 1 part of 5g
Folium Pini: 2 parts of 10g
Cacumen Platycladi: 2 parts of 10g
Preparation technology is;
To add 10 times of weight water according to the blended Chinese medicine medical material of above weight ratio, boil 5 hours, and extract volatile oil and decocting liquid,, obtain medicinal liquid and medicinal residues medical filtration; The water that adds 6 times of weight of medical material in medicinal residues extracts decocting liquid in the back of boiling, and decocting liquid is filtered the back taking liquid; Merge medicinal liquid twice, be concentrated into relative density 1.15, use medicinal ethanol precipitation, make medicinal liquid contain amount of alcohol and reach 70%, left standstill filtering extracting liquid 24 hours; This medicinal liquid mixes with volatile oil, adds medicinal alcohol and water, and transferring to this medicinal liquid, to contain amount of alcohol be 70%, and containing raw medicinal material concentration is 6%.
CN 03130584 2003-08-20 2003-08-20 Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation Expired - Fee Related CN1285385C (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007046642A1 (en) * 2005-10-19 2007-04-26 Chang Seon Song Composition comprising an extract of pine needle for preventing and treating human disease caused by viruses and the use thereof
WO2007046643A1 (en) * 2005-10-19 2007-04-26 Chang Seon Song Composition comprising an extract of pine needle for preventing and treating animal disease caused by viruses and the use thereof
CN102511515A (en) * 2012-01-13 2012-06-27 寻庆美 Spray for ICU (Intensive Care Unit) sterilization
CN111450197A (en) * 2020-04-01 2020-07-28 宁夏清华园知识产权研究与开发有限公司 Formula of pure traditional Chinese medicine external disinfectant containing ethanol
CN111713515A (en) * 2020-04-01 2020-09-29 宁夏清华园知识产权研究与开发有限公司 Pure traditional Chinese medicine formula for inhibiting infection by carrying out tracking targeted inactivation aiming at novel coronavirus transmission mechanism kinetics
CN114159524A (en) * 2021-10-26 2022-03-11 武汉三木生态科技有限公司 Vehicle-mounted traditional Chinese medicine sachet
CN114366782A (en) * 2022-01-25 2022-04-19 中国人民解放军西部战区总医院 Traditional Chinese medicine formula for resisting type 55 adenovirus and application
CN115969789A (en) * 2022-12-20 2023-04-18 广东岭南职业技术学院 Oral and nasal spray of epidemic prevention and sterilization qingkailing composition and preparation method thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007046642A1 (en) * 2005-10-19 2007-04-26 Chang Seon Song Composition comprising an extract of pine needle for preventing and treating human disease caused by viruses and the use thereof
WO2007046643A1 (en) * 2005-10-19 2007-04-26 Chang Seon Song Composition comprising an extract of pine needle for preventing and treating animal disease caused by viruses and the use thereof
CN102511515A (en) * 2012-01-13 2012-06-27 寻庆美 Spray for ICU (Intensive Care Unit) sterilization
CN102511515B (en) * 2012-01-13 2013-09-11 寻庆美 Spray for ICU (Intensive Care Unit) sterilization
CN111450197A (en) * 2020-04-01 2020-07-28 宁夏清华园知识产权研究与开发有限公司 Formula of pure traditional Chinese medicine external disinfectant containing ethanol
CN111713515A (en) * 2020-04-01 2020-09-29 宁夏清华园知识产权研究与开发有限公司 Pure traditional Chinese medicine formula for inhibiting infection by carrying out tracking targeted inactivation aiming at novel coronavirus transmission mechanism kinetics
CN114159524A (en) * 2021-10-26 2022-03-11 武汉三木生态科技有限公司 Vehicle-mounted traditional Chinese medicine sachet
CN114366782A (en) * 2022-01-25 2022-04-19 中国人民解放军西部战区总医院 Traditional Chinese medicine formula for resisting type 55 adenovirus and application
CN115969789A (en) * 2022-12-20 2023-04-18 广东岭南职业技术学院 Oral and nasal spray of epidemic prevention and sterilization qingkailing composition and preparation method thereof

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