CN114366782A - Traditional Chinese medicine formula for resisting type 55 adenovirus and application - Google Patents
Traditional Chinese medicine formula for resisting type 55 adenovirus and application Download PDFInfo
- Publication number
- CN114366782A CN114366782A CN202210084302.6A CN202210084302A CN114366782A CN 114366782 A CN114366782 A CN 114366782A CN 202210084302 A CN202210084302 A CN 202210084302A CN 114366782 A CN114366782 A CN 114366782A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- adenovirus
- medicine formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 83
- 241000701161 unidentified adenovirus Species 0.000 title claims abstract description 40
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 20
- 235000004611 garlic Nutrition 0.000 claims abstract description 20
- 241001519271 Ajuga Species 0.000 claims abstract description 18
- 241000218989 Trichosanthes Species 0.000 claims abstract description 18
- 241000906579 Actaea cimicifuga Species 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 240000002234 Allium sativum Species 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 241000951473 Schizonepeta Species 0.000 claims description 14
- 241000735527 Eupatorium Species 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 244000245420 ail Species 0.000 abstract 1
- 208000010370 Adenoviridae Infections Diseases 0.000 description 18
- 206010060931 Adenovirus infection Diseases 0.000 description 18
- 208000011589 adenoviridae infectious disease Diseases 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- 239000000284 extract Substances 0.000 description 11
- 206010037660 Pyrexia Diseases 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000003263 anti-adenoviral effect Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 230000003467 diminishing effect Effects 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010019345 Heat stroke Diseases 0.000 description 2
- 241000598171 Human adenovirus sp. Species 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 244000179560 Prunella vulgaris Species 0.000 description 2
- 241000951376 Schizonepeta tenuifolia Species 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000001773 anti-convulsant effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 229960003965 antiepileptics Drugs 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229940104299 cimicifugae rhizoma Drugs 0.000 description 2
- 230000000120 cytopathologic effect Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000008517 radix Trichosanthis Substances 0.000 description 2
- 235000008113 selfheal Nutrition 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 102400000888 Cholecystokinin-8 Human genes 0.000 description 1
- 101800005151 Cholecystokinin-8 Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000308663 Eupatorium fortunei Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine formula for resisting type 55 adenovirus and application thereof, and the traditional Chinese medicine formula for resisting adenovirus therapy application has the characteristics of convenient use and obvious antiviral effect; the traditional Chinese medicine formula comprises the following medicines: 10-15 parts of honeysuckle, 5-8 parts of Ajuga chinensis, 5-8 parts of garlic, 5-8 parts of cimicifuga foetida, 5-8 parts of trichosanthes root, 5-8 parts of herba eupatorii and 5-8 parts of herba schizonepetae.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for resisting type 55 adenovirus and application thereof.
Background
Human adenoviruses (HAdV) are a double-stranded DNA virus without envelope and divided into a-G7 serological groups, of which group B adenovirus infection has become an important factor in acute respiratory diseases at present. Group B can be divided into subgroups B1 and B2, B1 mainly comprises types 3, 7, 16, 21 and 51; b2 includes types 14, 34, 35 and 55. In recent years, HAdV-55 is one of the important causes of adult community-acquired pneumonia, and is also responsible for respiratory tract infection of children in a certain proportion, and can cause collective transmission in campuses, communities and the like. Adenovirus infection has no specific medicine and obvious curative effect, and is cured mainly by means of eliminating virus with the body's own immune system. Therefore, the development of highly effective, safe and low-cost anti-adenovirus drugs is helpful for the treatment of adenovirus infection.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine formula for resisting type 55 adenovirus and application thereof, and the traditional Chinese medicine formula for resisting adenovirus therapy has the characteristics of convenience in use and obvious antiviral effect.
The invention is realized by the following technical scheme: a traditional Chinese medicine formula for resisting type 55 adenovirus is composed of the following medicines:
10-15 parts of honeysuckle, 5-8 parts of Ajuga chinensis, 5-8 parts of garlic, 5-8 parts of cimicifuga foetida, 5-8 parts of trichosanthes root, 5-8 parts of herba eupatorii and 5-8 parts of herba schizonepetae.
Wherein, the honeysuckle has the efficacy of clearing away heat and toxic materials. It can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases. The anti-adenovirus effect is mainly achieved in the components of the invention;
the selfheal fruit-spike has the efficacies of relieving cough and reducing sputum, clearing heat, cooling blood, reducing swelling, detoxifying and the like. The components of the invention mainly have the effects of resisting adenovirus infection and clearing heat;
garlic has the effects of detoxifying, reducing swelling, warming spleen and stomach and the like. The components of the invention mainly have the effects of resisting adenovirus infection and detoxifying;
cimicifugae rhizoma has antipyretic, cooling, antiinflammatory, analgesic, tranquilizing, anticonvulsant, and immunity enhancing effects. The components of the invention mainly have the functions of resisting adenovirus infection, enhancing immunity and the like;
trichosanthis radix, radix Trichosanthis, has effects of clearing heat, promoting fluid production, detumescence and expelling pus. The components of the invention mainly have the effects of resisting adenovirus infection and relieving fever;
herba Eupatorii has expectorant, antiviral, and anticancer effects. The component of the invention mainly has the effect of resisting adenovirus infection;
schizonepeta tenuifolia has the functions of inducing sweat, relieving exterior syndrome, diminishing inflammation, etc. The components of the invention mainly have the effects of relieving fever and diminishing inflammation.
Further, in order to better realize the traditional Chinese medicine formula for resisting the 55-type adenovirus, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
10 parts of honeysuckle, 5 parts of Ajuga chinensis Benth, 5 parts of garlic, 5 parts of cimicifuga foetida, 5 parts of trichosanthes root, 5 parts of eupatorium and 5 parts of schizonepeta.
Further, in order to better realize the traditional Chinese medicine formula for resisting the 55-type adenovirus, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
15 parts of honeysuckle, 8 parts of Ajuga chinensis, 6 parts of garlic, 7 parts of cimicifuga foetida, 8 parts of trichosanthes root, 7 parts of eupatorium and 6 parts of schizonepeta.
Further, in order to better realize the traditional Chinese medicine formula for resisting the 55-type adenovirus, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
12 parts of honeysuckle, 6 parts of Ajuga chinensis, 7 parts of garlic, 8 parts of cimicifuga foetida, 6 parts of trichosanthes root, 6 parts of fortune eupatorium herb and 8 parts of fineleaf schizonepeta herb.
Further, in order to better realize the traditional Chinese medicine formula for resisting the 55-type adenovirus, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
13 parts of honeysuckle, 7 parts of Ajuga chinensis, 8 parts of garlic, 6 parts of cimicifuga foetida, 7 parts of trichosanthes root, 8 parts of fortune eupatorium herb and 7 parts of fineleaf schizonepeta herb.
An application of a traditional Chinese medicine formula for resisting type 55 adenovirus, which is applied as a medicine for resisting type 55 adenovirus.
Further, in order to better realize the application of the traditional Chinese medicine formula for resisting the 55-type adenovirus, the following setting modes are particularly adopted: the traditional Chinese medicine formula can be a water agent, a tablet, a pill or powder when being applied as the 55-type adenovirus resisting medicine.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the traditional Chinese medicine formula provided by the invention adopts pure traditional Chinese medicine components, and has the characteristics of convenience in use and obvious antiviral effect on anti-adenovirus treatment.
Drawings
FIG. 1 shows that the water extract of the Chinese medicinal formula inhibits adenovirus infection.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
It is worth noting that in the technical field, in the case of partial material overlap, it cannot be simply considered that the parameter quantity change therein can be completed only by a limited number of experiments, thereby negating the creativity of the technical solution.
Example 1:
a traditional Chinese medicine formula for resisting type 55 adenovirus is used for resisting adenovirus therapy, particularly for resisting type 55 adenovirus therapy, and comprises the following medicines:
10-15 parts of honeysuckle, 5-8 parts of Ajuga chinensis, 5-8 parts of garlic, 5-8 parts of cimicifuga foetida, 5-8 parts of trichosanthes root, 5-8 parts of herba eupatorii and 5-8 parts of herba schizonepetae.
Wherein, the honeysuckle has the efficacy of clearing away heat and toxic materials. It can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases. The anti-adenovirus effect is mainly achieved in the components of the invention;
the selfheal fruit-spike has the efficacies of relieving cough and reducing sputum, clearing heat, cooling blood, reducing swelling, detoxifying and the like. The components of the invention mainly have the effects of resisting adenovirus infection and clearing heat;
garlic has the effects of detoxifying, reducing swelling, warming spleen and stomach and the like. The components of the invention mainly have the effects of resisting adenovirus infection and detoxifying;
cimicifugae rhizoma has antipyretic, cooling, antiinflammatory, analgesic, tranquilizing, anticonvulsant, and immunity enhancing effects. The components of the invention mainly have the functions of resisting adenovirus infection, enhancing immunity and the like;
trichosanthis radix, radix Trichosanthis, has effects of clearing heat, promoting fluid production, detumescence and expelling pus. The components of the invention mainly have the effects of resisting adenovirus infection and relieving fever;
herba Eupatorii has expectorant, antiviral, and anticancer effects. The component of the invention mainly has the effect of resisting adenovirus infection;
schizonepeta tenuifolia has the functions of inducing sweat, relieving exterior syndrome, diminishing inflammation, etc. The components of the invention mainly have the effects of relieving fever and diminishing inflammation.
Example 2:
the embodiment is further optimized on the basis of the above embodiment, and the same parts as those in the above technical solution will not be described herein again, and in order to further better implement the traditional Chinese medicine formula for resisting adenovirus 55 according to the present invention, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
10 parts of honeysuckle, 5 parts of Ajuga chinensis Benth, 5 parts of garlic, 5 parts of cimicifuga foetida, 5 parts of trichosanthes root, 5 parts of eupatorium and 5 parts of schizonepeta.
Example 3:
the embodiment is further optimized on the basis of embodiment 1, and the same parts as those in the above technical scheme will not be described herein again, and in order to better implement the traditional Chinese medicine formula for resisting type 55 adenovirus of the present invention, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
15 parts of honeysuckle, 8 parts of Ajuga chinensis, 6 parts of garlic, 7 parts of cimicifuga foetida, 8 parts of trichosanthes root, 7 parts of eupatorium and 6 parts of schizonepeta.
Example 4:
the embodiment is further optimized on the basis of embodiment 1, and the same parts as those in the above technical scheme will not be described herein again, and in order to better implement the traditional Chinese medicine formula for resisting type 55 adenovirus of the present invention, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
12 parts of honeysuckle, 6 parts of Ajuga chinensis, 7 parts of garlic, 8 parts of cimicifuga foetida, 6 parts of trichosanthes root, 6 parts of fortune eupatorium herb and 8 parts of fineleaf schizonepeta herb.
Example 5:
the embodiment is further optimized on the basis of embodiment 1, and the same parts as those in the above technical scheme will not be described herein again, and in order to better implement the traditional Chinese medicine formula for resisting type 55 adenovirus of the present invention, the following setting modes are particularly adopted: the traditional Chinese medicine formula comprises the following medicines:
13 parts of honeysuckle, 7 parts of Ajuga chinensis, 8 parts of garlic, 6 parts of cimicifuga foetida, 7 parts of trichosanthes root, 8 parts of fortune eupatorium herb and 7 parts of fineleaf schizonepeta herb.
Example 6:
the embodiment is further optimized on the basis of any one of the embodiments, the same parts as the technical scheme are not repeated herein, and the application of the traditional Chinese medicine formula for resisting the 55-type adenovirus is to use the traditional Chinese medicine formula as a medicine for resisting the 55-type adenovirus.
Taking 10-15 parts of honeysuckle, 5-8 parts of Ajuga chinensis, 5-8 parts of garlic, 5-8 parts of cimicifuga foetida, 5-8 parts of trichosanthes root, 5-8 parts of fortune eupatorium herb and 5-8 parts of fineleaf schizonepeta herb according to the proportion, combining the raw materials in a powder form to prepare a water extract, and then diluting the water extract to (20-30) mg/mL by adopting PBS.
HEp-2 cells were plated and cultured overnight. The traditional Chinese medicine water extract and 100 times of TCID 5055 type adenovirus are mixed uniformly in equal volume, and the mixture is inoculated into a 96-well plate, wherein the final concentration of the traditional Chinese medicine water extract is 2-5 mg/mL. Each specimen was used to infect 3 wells, along with a Virus Control (VC) and a Cell Control (CC) at 37 deg.C, 5% CO2Standing for culture, and determining the cytopathic effect of adenovirus infection by CCK8 test. The results show that the water extract of the traditional Chinese medicine composition (the water extract of the traditional Chinese medicine formula, namely the water aqua form) can obviously inhibit the cytopathogenic effect generated by adenovirus infection.
Example 7:
the embodiment is further optimized on the basis of the above embodiment, the same parts as those in the above technical scheme will not be described again, and the application of a traditional Chinese medicine formula for resisting type 55 adenovirus is applied as a medicine for resisting type 55 adenovirus as shown in fig. 1.
In this embodiment, the amount of each component in the traditional Chinese medicine formula is, in grams: 1g of honeysuckle, 0.5g of Ajuga chinensis, 0.5g of garlic, 0.5g of rhizoma cimicifugae, 0.5g of trichosanthes root, 0.5g of eupatorium fortunei and 0.5g of schizonepeta, and the early stage of the traditional Chinese medicines are prepared into powder, and then water extract is further prepared and diluted to 25mg/mL by adopting PBS.
HEp-2 cells were plated and cultured overnight. The traditional Chinese medicine water extract and 100 times of TCID 5055 type adenovirus are mixed uniformly in equal volume, and the mixture is inoculated into a 96-well plate, and the final concentration of the traditional Chinese medicine water extract is 3.125 mg/mL. Each specimen was used to infect 3 wells, along with a Virus Control (VC) and a Cell Control (CC) at 37 deg.C, 5% CO2And (5) standing for culture, and detecting the adenovirus infection level in the infected cells by a fluorescent quantitative PCR method after 48 hours. As shown in FIG. 1, the adenovirus infection level in the cells of the group of herbal extracts was reduced by about 80% when the virus control group was taken as 100%. The result shows that the water extract of the traditional Chinese medicine composition can obviously reduce the infection level of adenovirus.
Example 8:
the present embodiment is further optimized based on embodiment 6 or 7, and the same parts as those in the foregoing technical solutions will not be described herein again, and in order to better implement the application of the anti-55-adenovirus traditional Chinese medicine formula of the present invention, the following setting modes are particularly adopted: the traditional Chinese medicine formula can be a water agent, a tablet, a pill or powder when being applied as the 55-type adenovirus resisting medicine.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and all simple modifications and equivalent variations of the above embodiments according to the technical spirit of the present invention are included in the scope of the present invention.
Claims (7)
1. A traditional Chinese medicine formula for resisting type 55 adenovirus is characterized in that: the traditional Chinese medicine formula comprises the following medicines:
10-15 parts of honeysuckle, 5-8 parts of Ajuga chinensis, 5-8 parts of garlic, 5-8 parts of cimicifuga foetida, 5-8 parts of trichosanthes root, 5-8 parts of herba eupatorii and 5-8 parts of herba schizonepetae.
2. The traditional Chinese medicine formula for resisting adenovirus 55 according to claim 1, wherein the formula comprises: the traditional Chinese medicine formula comprises the following medicines:
10 parts of honeysuckle, 5 parts of Ajuga chinensis Benth, 5 parts of garlic, 5 parts of cimicifuga foetida, 5 parts of trichosanthes root, 5 parts of eupatorium and 5 parts of schizonepeta.
3. The traditional Chinese medicine formula for resisting adenovirus 55 according to claim 1, wherein the formula comprises: the traditional Chinese medicine formula comprises the following medicines:
15 parts of honeysuckle, 8 parts of Ajuga chinensis, 6 parts of garlic, 7 parts of cimicifuga foetida, 8 parts of trichosanthes root, 7 parts of eupatorium and 6 parts of schizonepeta.
4. The traditional Chinese medicine formula for resisting adenovirus 55 according to claim 1, wherein the formula comprises: the traditional Chinese medicine formula comprises the following medicines:
12 parts of honeysuckle, 6 parts of Ajuga chinensis, 7 parts of garlic, 8 parts of cimicifuga foetida, 6 parts of trichosanthes root, 6 parts of fortune eupatorium herb and 8 parts of fineleaf schizonepeta herb.
5. The traditional Chinese medicine formula for resisting adenovirus 55 according to claim 3, wherein the formula comprises: the traditional Chinese medicine formula comprises the following medicines:
13 parts of honeysuckle, 7 parts of Ajuga chinensis, 8 parts of garlic, 6 parts of cimicifuga foetida, 7 parts of trichosanthes root, 8 parts of fortune eupatorium herb and 7 parts of fineleaf schizonepeta herb.
6. The application of a traditional Chinese medicine formula for resisting type 55 adenovirus is characterized in that: the use of a traditional Chinese medicine formulation according to any one of claims 1 to 5 as a medicament against type 55 adenoviruses.
7. The use of the traditional Chinese medicine formulation for resisting adenovirus 55 according to claim 6, wherein: the traditional Chinese medicine formula can be a water agent, a tablet, a pill or powder when being applied as the 55-type adenovirus resisting medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210084302.6A CN114366782A (en) | 2022-01-25 | 2022-01-25 | Traditional Chinese medicine formula for resisting type 55 adenovirus and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210084302.6A CN114366782A (en) | 2022-01-25 | 2022-01-25 | Traditional Chinese medicine formula for resisting type 55 adenovirus and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114366782A true CN114366782A (en) | 2022-04-19 |
Family
ID=81145577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210084302.6A Pending CN114366782A (en) | 2022-01-25 | 2022-01-25 | Traditional Chinese medicine formula for resisting type 55 adenovirus and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114366782A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583179A (en) * | 2003-08-20 | 2005-02-23 | 天津药物研究院 | Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation |
| CN106798863A (en) * | 2017-03-29 | 2017-06-06 | 卢仁华 | The medicine of adenovirus pneumonia |
-
2022
- 2022-01-25 CN CN202210084302.6A patent/CN114366782A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583179A (en) * | 2003-08-20 | 2005-02-23 | 天津药物研究院 | Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation |
| CN106798863A (en) * | 2017-03-29 | 2017-06-06 | 卢仁华 | The medicine of adenovirus pneumonia |
Non-Patent Citations (3)
| Title |
|---|
| 冯欣煜等: "金银花的现代药理和临床运用研究进展", 《中医研究》 * |
| 李永梅等: "金银花的抗腺病毒作用研究", 《华西药学杂志》 * |
| 超凡子: "抗病毒中药大全", 《百度》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103169891B (en) | Novel vitamin C yinqiao tablet | |
| CN1562151A (en) | Medicinal formulation for treating upper respiratory track infection and its design method | |
| CN103768308B (en) | A kind of pharmaceutical composition that is used for the treatment of the infection of the upper respiratory tract and preparation method thereof | |
| CN1047090C (en) | Plaster for curing cough with dyspnea | |
| CN100353953C (en) | Traditional Chinese medicina preparation for treating oral cavity, throat disease and its preparation method | |
| CN1437963A (en) | Medicine for treating common cold and preparation method | |
| CN1096206A (en) | Pestilence-curing medicine (Kewenning) | |
| CN115400194B (en) | Traditional Chinese medicine composition for treating children epidemic and application thereof | |
| CN114366782A (en) | Traditional Chinese medicine formula for resisting type 55 adenovirus and application | |
| CN116139237B (en) | A Chinese medicinal composition for preventing and treating respiratory tract infection caused by coronavirus, and its application | |
| CN100352468C (en) | Yinzhihuang tablet of oriental wormwood, cape jasmine and baicalin, and its preparing and detecting method | |
| CN102379958B (en) | Chinese medicinal preparation for resisting bacteria, diminishing inflammation, eliminating phlegm and relieving cough and preparation method thereof | |
| CN1102104A (en) | Adhesive plaster capable of detoxicating and resolving a mass | |
| CN103027906A (en) | Application of arctigenin in treating anemia | |
| CN1335174A (en) | Stomatopathy and throat disease treating health care medicine and its production process | |
| CN102552440B (en) | Anti-asthmatic and anti-inflammatory medicament and preparation method and application thereof | |
| CN1059104C (en) | Capsule for anti hepatitis B | |
| CN102688330B (en) | Biological Chinese medicine film and preparation method thereof | |
| CN1176123A (en) | Medicine for chronic hepatitis B and its preparation | |
| CN105267395A (en) | Compound Yuxingcao syrup extract, compound Yuxingcao syrup and its preparation method | |
| CN104800513A (en) | Traditional Chinese medicine composition for treating cough variant asthma | |
| CN105343503B (en) | A kind of pharmaceutical composition that treating sphagitis and its application | |
| CN1190229C (en) | Medicine for curing hepatitis B | |
| CN111375036B (en) | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof | |
| CN108404059A (en) | A kind of Chinese medicine composition for treating anti-type thyroid adenoma on liver-yang |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220419 |