CN1190229C - Medicine for curing hepatitis B - Google Patents

Abstract

The present invention discloses a traditional Chinese medicine for treating hepatitis B, which is mainly prepared from stringy stonecrop herb, virgate wormwood herb, purslane herb, red peony root, red sage root, giant knotweed rhizome, oldenlandia, Chinese angelica, Chinese magnolivine fruit, tuckahoe, lightyellow sophora root, curcuma root, milkvetch root, China siphonostegia, malt, gizzard membrane, stir-baked Massa Medicata Fermentata and the like as raw materials. The traditional Chinese medicine has the advantages of wide medicine source, easy acquisition, low cost, no toxicity and harm to human bodies, high safety and reliability for medication, short treatment course, rapid effect and obvious curative effect.

Description

A kind of medicine for the treatment of hepatitis B

(1) technical field:

The present invention relates to a kind of medicine for the treatment of hepatitis B, is the Chinese medicine preparation of treatment hepatitis B specifically.

(2) technical background:

Hepatitis B is the higher infectious disease of a kind of sickness rate, especially in China, hepatitis B patient and virus carrier are up to people more than 100,000,000, account for 10% of country's total population, in some high region of disease, hepatitis B patient reaches more than 70% unexpectedly, present stage is the traditional Chinese medical science or doctor trained in Western medicine no matter, treatment to hepatitis B does not all have specially good effect, especially in the rural area, owing to reasons such as treatment instability, treatment phase length, expense height, cause some hepatitis B patients to develop into liver cirrhosis even hepatocarcinoma, all cause very big injury for patient and family.

(3) summary of the invention:

The object of the present invention is to provide a kind of Chinese medicine preparation of effective treatment hepatitis B, through clinical verification, medicine of the present invention has effects such as obviously killing hepatitis B virus, promotion liver cell regeneration, enhancing liver immunity.

Medicine of the present invention is to make (by weight) by following raw material:

Herba Sedi 7-10 Herba Artemisiae Scopariae 7-10

Herba Portulacae 7-10 Radix Paeoniae Rubra 5.5-7.5

Radix Salviae Miltiorrhizae 5.5-7.5 Rhizoma Polygoni Cuspidati 5.5-7.5

Herba Hedyotidis Diffusae 5.5-7.5 Radix Angelicae Sinensis 5.5-7.5

Fructus Schisandrae Chinensis 5.5-7.5 Poria 5.5-7.5

Radix Sophorae Flavescentis 5.5-7.5 Radix Curcumae 5.5-7.5

Radix Astragali 5.5-7.5 Herba Siphonostegiae 5.5-7.5

Fructus Hordei Germinatus 5.5-7.5 Endothelium corneum 5.5-7.5

Massa Medicata Fermentata (parched to brown) 5.5-7.5

Above-mentioned each component preferred weight proportioning is:

Herba Sedi 8 Herba Artemisiae Scopariaes 8

Herba Portulacae 8 Radix Paeoniae Rubra 6

Radix Salviae Miltiorrhizae 6 Rhizoma Polygoni Cuspidati 6

Herba Hedyotidis Diffusae 6 Radix Angelicae Sinensis 6

Fructus Schisandrae Chinensis 6 Poria 6

Radix Sophorae Flavescentis 6 Radix Curcumaes 6

The Radix Astragali 6 Herba Siphonostegiae 6

Fructus Hordei Germinatus 6 Endothelium corneum 6

Massa Medicata Fermentata (parched to brown) 6

The preparation method of medicine of the present invention is:

With the selected raw material of said medicine, be ground into fine powder after the oven dry, after the sieve mixing, per 100 grams add 20-40 gram refined honey and low amounts of water, make water-honeyed pill, dry again getting final product.

Perhaps,, be ground into fine powder after the oven dry, further pulverize behind the mix homogeneously, cross 100 mesh sieves, incapsulate and to get the selected raw material of said medicine.

The clinical use result of medicine 1995-2001 of the present invention shows, has the following advantages:

1, our medicine source is extensive, easily adopts to be easy to get, and is with low cost;

2, we adopt natural drug, and nontoxic to human body, drug safety is reliable;

3, production technology is simple, taking convenience, and short treating period, instant effect, and evident in efficacy.

For showing the therapeutic effect of medicine of the present invention to hepatitis B, the present invention is through clinical observation, and data is as follows:

1, case choice criteria:

Traditional medicine thinks that the hepatitis B pathogenesis is: damp and hot surplus heresy is not most, stagnation of liver-QI with deficiency of the spleen, and QI and blood deficiency is so the differential diagnosis in tcm standard is: refreshing tired power, the soreness of waist, dizziness, tinnitus, dim eyesight, red tongue, thready and stringy pulse.

2, diagnostic criteria:

" viral hepatitis is prevented and treated scheme " of Shanghai meeting revision is diagnostic criteria with nineteen ninety, and hepatitis history surpasses half a year, and more than one positive signs that have present situation HBV to infect.

3, curative effect judging standard:

Related content with 1993 " traditional Chinese medical science Clinical Researches of New Drugs guideline " first volume is a curative effect judging standard.Produce effects: symptom, sign disappear, and liver function is normal, and the hbv replication index all disappears; Effectively: symptom and liver function are all improved or the hbv replication index has more than one and turns out cloudy; Invalid: symptom, sign do not change, and liver function is not improved.

4, physical data:

Select case 500 examples altogether by standard: 500 examples are organized in treatment, and great three positive has 225 examples, and small three positive has 190 examples, HBsAg carrier 85 examples, male's 382 examples wherein, women's 118 examples, 40.5 years old mean age, average course of disease 2.8 years; Matched group 100 examples, great three positive has 51 examples, and small three positive has 38 examples, HBsAg carrier 11 examples, male's 72 examples wherein, women's 28 examples, 39.6 years old mean age, average course of disease 2.6 years.

Administrated method and consumption: the treatment group is taken medicine of the present invention, and is oral, every day 3 times, and one time 5 gram, 3 months is a course of treatment; Matched group is taken " hepatitis B recuperating medicine capsule ", and is oral, every day 3 times, and one time 12 gram, 3 months is a course of treatment.

Result such as following table:

The treatment group hepatitis B patient situation observation table of turning out cloudy

Table 1:

Type	Before the treatment						After the treatment
														The case sum	HBsAg	Anti-HBs	HBeAg	Anti-HBe	Anti-HBc	The number of turning out cloudy	Do not change number	HBsAg	Anti-HBs	HBeAg	Anti-HBe	Anti-HBc
	Great three positive	225	+	-	+	-	+	216		-	+	-	-														-
														9	+	-	+	-	-
								Small three positive	190	+	-	-	+							+	182		-	+	-	-	-
	8	+	-	-	+	+
							Carrier							85	+	-	-	-	-		82		-	+	-	-	-
	3	+	-	-	-	-
								Add up to	500												480	20

Treatment group and matched group effective percentage comparison sheet

Table 2:

Group	Example number (%)	Produce effects (%)	Effectively (%)	Invalid (%)	Total effective rate (%)
						The treatment group	500	288(57.6)	192(38.4)	20(4)	96
Matched group	100	32(32)	30(30)	38(38)	62

Result of study shows: take medicine of the present invention, obvious effective rate is 57.6%, and effective percentage is 38.4%, and total effective rate is 96%, obviously is better than matched group at aspects such as killing hepatitis B virus, promotion liver cell regeneration, enhancing liver immunity.

(4), embodiment:

Get raw material (gram) by following proportioning

Herba Sedi 8 Herba Artemisiae Scopariaes 8

Herba Portulacae 8 Radix Paeoniae Rubra 6

Radix Salviae Miltiorrhizae 6 Rhizoma Polygoni Cuspidati 6

Herba Hedyotidis Diffusae 6 Radix Angelicae Sinensis 6

Fructus Schisandrae Chinensis 6 Poria 6

Radix Sophorae Flavescentis 6 Radix Curcumaes 6

The Radix Astragali 6 Herba Siphonostegiae 6

Fructus Hordei Germinatus 6 Endothelium corneum 6

Massa Medicata Fermentata (parched to brown) 6

Preparation method is as follows:

With the selected raw material of said medicine, be ground into fine powder after the oven dry, after the sieve mixing, per 100 grams add 20-40 gram refined honey and low amounts of water, make water-honeyed pill, dry again getting final product.

Perhaps,, be ground into fine powder after the oven dry, further pulverize behind the mix homogeneously, cross 100 mesh sieves, incapsulate and to get the selected raw material of said medicine.

Claims (2)

1, a kind of medicine for the treatment of hepatitis B is characterized in that it is the medicament of being made by the following weight proportion raw material:

Herba Sedi 7-10 Herba Artemisiae Scopariae 7-10

Herba Portulacae 7-10 Radix Paeoniae Rubra 5.5-7.5

Radix Salviae Miltiorrhizae 5.5-7.5 Rhizoma Polygoni Cuspidati 5.5-7.5

Herba Hedyotidis Diffusae 5.5-7.5 Radix Angelicae Sinensis 5.5-7.5

Fructus Schisandrae Chinensis 5.5-7.5 Poria 5.5-7.5

Radix Sophorae Flavescentis 5.5-7.5 Radix Curcumae 5.5-7.5

Radix Astragali 5.5-7.5 Herba Siphonostegiae 5.5-7.5

Fructus Hordei Germinatus 5.5-7.5 Endothelium corneum 5.5-7.5

Massa Medicata Fermentata (parched to brown) 5.5-7.5.

2, the medicine of treatment hepatitis B as claimed in claim 1, wherein the weight proportion of each raw material is:

Herba Sedi 8 Herba Artemisiae Scopariaes 8

Herba Portulacae 8 Radix Paeoniae Rubra 6

Radix Salviae Miltiorrhizae 6 Rhizoma Polygoni Cuspidati 6

Herba Hedyotidis Diffusae 6 Radix Angelicae Sinensis 6

Fructus Schisandrae Chinensis 6 Poria 6

Radix Sophorae Flavescentis 6 Radix Curcumaes 6

The Radix Astragali 6 Herba Siphonostegiae 6

Fructus Hordei Germinatus 6 Endothelium corneum 6

Massa Medicata Fermentata (parched to brown) 6.