CN111713515A

CN111713515A - Pure traditional Chinese medicine formula for inhibiting infection by carrying out tracking targeted inactivation aiming at novel coronavirus transmission mechanism kinetics

Info

Publication number: CN111713515A
Application number: CN202010248971.3A
Authority: CN
Inventors: 张文举; 张嘉馨; 张嘉乐; 王皓
Original assignee: Ningxia Qinghuayuan Intellectual Property Research And Development Co ltd
Current assignee: Ningxia Qinghuayuan Intellectual Property Research And Development Co ltd
Priority date: 2020-04-01
Filing date: 2020-04-01
Publication date: 2020-09-29

Abstract

The invention relates to a pure traditional Chinese medicine formula for carrying out tracking targeted inactivation and infection inhibition aiming at the transmission mechanism kinetics of a novel coronavirus, which is a pure traditional Chinese medicine formula for carrying out tracking targeted inactivation and infection inhibition covering a virus transmission path according to the transmission mode, the infection path and the development status of the novel coronavirus. The virus inactivation device is suitable for virus inactivation without dead angles in daily work and living environments, and is particularly suitable for crowded places such as medical institutions, workplaces and public places. The disinfection product related by the invention has simple and easy preparation process and obvious effect, and can be used as the necessary self-made air sterilization and disinfection aromatherapy in daily work and life.

Description

Pure traditional Chinese medicine formula for inhibiting infection by carrying out tracking targeted inactivation aiming at novel coronavirus transmission mechanism kinetics

Technical Field

The invention relates to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation, in particular to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation aiming at novel dynamics of coronavirus transmission mechanism.

Technical Field

According to the existing clinical data, the pneumonia transmission routes of the novel coronavirus infection comprise: (1) direct propagation: the patient is in close direct contact with the virus carrier, or when the virus carrier sneezes, coughs and speaks, the close contact causes other people to directly inhale the virus through the respiratory tract; (2) droplet propagation: some small droplets of droplets carrying viruses can be dispersed in the air along with the air flow, and in a dense indoor environment or a closed indoor environment, the droplets of the viruses contained in the air can cause other people to inhale the viruses during breathing, so that the infection is caused. (3) Contact propagation: the droplets sprayed during sneezing, coughing and speaking can not float in the air for a long time, fall on the ground or the surface of an object, and rapidly dry within minutes or even seconds, and shrink into 'droplet cores' consisting of proteins and pathogens to float in the air. The spray core will drift for a long distance along with the air flow and deposit on the surface of the article. These active viruses that fall on the surface of the object can also cause infection by direct contact with contaminated hands, which in turn contact with mucous membranes such as the oral cavity, nasal cavity, eyes, etc., such as digging nostrils, rubbing eyes, etc.

The virus droplet core can keep activity in dry air for 2 hours at most, can survive for 24 hours in a humid environment, can float along with the air flow, and can survive for 5 days at most when settled on the surface of an object. An infected area is formed when the concentration of active viruses in the indoor air reaches a certain level. The hospital is not the only place where the virus air is generated, and the virus air is generated in places with dense crowds, such as: workplaces, public places, families and other indoor activity places.

At present, the following measures are taken for indoor disinfection and daily protection:

1. alcohol disinfection: the alcohol can effectively kill virus on the surface of an object. The amount of the alcohol molecules used must be controlled because the alcohol molecules in the indoor air reach a certain concentration, and the alcohol molecules can cause combustion or explosion when exposed to open fire or electric spark. And the human body is damaged by inhaling excessive alcohol, so that the alcohol cannot be used as a method for daily air disinfection.

2.84 disinfection by disinfectant: 84 the disinfectant is applied to the surface of an object to effectively kill viruses, and free chlorine released in the using process of the disinfectant possibly causes poisoning. Chlorine is a toxic gas that invades the body mainly through the respiratory tract and dissolves in the water contained in the mucous membranes, causing dyspnea, and the symptom of chlorine poisoning is the occurrence of severe cough. When the symptoms are severe, pulmonary edema can occur, leading to dyspnea and death. Chlorine gas entering the body from the esophagus can cause nausea, vomiting, chest pain and diarrhea. The maximum allowable chlorine content in 1L of air is 0.001mg, and the excessive chlorine content can cause human body poisoning.

3. Ultraviolet and ozone disinfection measures: the measure has requirements on indoor temperature and humidity, and the disinfection direction needs to be determined manually and directionally; a certain time limit is necessary when using the ultraviolet irradiation lamp and the ultraviolet irradiation lamp cannot be used when someone is present; ultraviolet rays can only disinfect the irradiation area, and can not disinfect in a covering and all-round way.

According to the characteristics and the disinfection degree of virus transmission and infection and the use safety factor, a disinfection method with the same transmission dynamic characteristics as the virus is required to ensure that all air coverage areas can be subjected to omnibearing dead-angle-free virus targeted killing, and no additional damage or health safety hidden trouble can be caused to life bodies. First, viral transmission of infection requires several properties:

1. crowded indoor activity place

2. The possibility of the existence of spray core in the place covered by air

3. The droplet can drift with the air

4. The spray core can sink on the surface of the object (the survival time can reach 5 days at most)

5. Can enter human body through eye conjunctiva, nasal mucosa, oral mucosa, etc. for infection.

According to the respiratory system structure of human body, the path of virus entering human body through respiration and infecting is: nasal cavity, pharynx, laryngeal cavity, trachea, bronchi, lungs. Among them, the viscous liquid secreted from goblet cells in the trachea and bronchi in the respiratory system plays a role in moistening the air entering the lungs and adhering dust and microorganisms in the air. Ciliated cells gradually push mucus, which contains dust and microorganisms, to the pharynx by swinging in order. Subsequently, the mucus is expectorated by the body or swallowed into the stomach. However, when the virus invades respiratory tract to cause inflammation, the congestion and edema of the mucous membranes of the trachea and the bronchus are caused, and the secretion of mucus is increased; the immune system of the human body will be antiviral. In confrontation, DNA "leaks" out after damaged cells are damaged; the free DNA, after binding to mucin in the mucus, becomes a viscous substance. The viscosity is increased, and ciliated cells cannot normally swing to clean the ciliated cells, so that the sputum stops storing and coagulating. This is often referred to as sputum. Thus normal persons are normally free of sputum. The reason why sputum actually causes diseases is because sputum has the characteristic of 'traveling along with qi without place'. The sputum also can be pushed to move along with the transportation and transformation of the air in the human body, and the blockage at any position can cause the corresponding tissues to block the organs to generate pathological changes, and the respiratory tract blockage can cause respiratory failure.

After a human body is contacted with viruses, a certain time is required from invasion into the body or action on the body to the reaction of the body or the beginning of the symptom presentation, and the time is the virus hidden period (also called latent period). The incubation period of the novel coronavirus is 14 days at most, and the incubation period of individual patients with special constitutions is 1-2 days or 1 month, and is 2-5 days on average. The speed of the nasal mucosa absorbing the effective components of the medicine is far greater than the pathogenic speed of the virus infecting human body, because the surface area of the human nasal mucosa is about 150cm²The mucosa has a plurality of micro fluff, which greatly increases the effective area of drug absorption; the mucous membrane layer of the nasal cavity is very thin, abundant blood vessels and lymphatic vessels exist under the mucous membrane, and drug molecules are easy to absorb through the mucous membrane of the nasal cavity; in addition, the metabolic action of enzymes in the nasal cavity is very small. The nasal mucosa immunity is different from other part immunity, not only can induce local mucosa immune response, but also can induce system immune response, and the immune effect is similar to that of subcutaneous injection immunity. The medicine can directly enter human body circulation after being absorbed through nasal mucosa. Therefore, the method can comprehensively and effectively avoid virus infection in daily work and life; during treatment of patients already infected with the virus, competition with the time of viral infection is required to achieve the goal of combating the extent of infection. The nasal absorption of the effective components of the medicine has double-layer competitive advantages of high speed and high medicine effect, and can provide enough treatment time for patients. The most serious damage of human body after virus infection is lung, and the function of immune system is reduced, so that the human body is easy to be infected by other pathogenic viruses to aggravate the life risk of patients. The right and proper air sterilization and disinfection mode can prevent the patient from being invaded by other germs while resisting the new coronavirus. Therefore, the invention is not only suitable for indoor sterilization and disinfection of healthy people without virus infection in daily work and life, but also can be used for auxiliary sterilization and disinfection during the treatment of infected people, thereby enhancing the virus resistance and striving for more treatment time for patients.

Disclosure of Invention

The invention relates to a pure traditional Chinese medicine protection formula for carrying out tracking targeted inactivation and infection inhibition on a virus transmission power path, in particular to a pure traditional Chinese medicine protection formula for carrying out tracking targeted inactivation and infection inhibition on a novel coronavirus transmission power path. Based on the virus propagation mechanism kinetics and the infection mode path, the invention provides an innovative formula with the effects of inhibiting inactivated viruses, ventilating the lung, eliminating phlegm and eliminating dampness. The invention is prepared according to the successful case of protection against epidemic diseases in China ancient and modern times and by combining the transmission path of viruses and the prescription of infection mode, not only can effectively inactivate the viruses in the air, but also can be absorbed by the human body and act on the purification and disinfection of the respiratory system. Has the effects of freeing lung, reducing phlegm and accelerating virus to be discharged out of the body while disinfecting the body. The main raw materials are as follows: rhizoma atractylodis, folium artemisiae argyi, herba agastaches, orange peel, platycodon grandiflorum and folium perillae. The raw materials of the invention have the efficacies of ventilating lung, eliminating phlegm and eliminating dampness, and contain a large amount of volatile oil, thus being capable of effectively changing virus infection and breeding environment to prevent deterioration. Compared with other disinfection measures in the prior art, the use method of the invention can effectively kill viruses existing in all indoor air coverage areas in an all-around and dead-angle-free manner, can also play a role in inhibiting reproduction of the viruses entering the respiratory system of a human body, and does not cause additional damage to the human body due to residues after ultraviolet rays or chemical agents are disinfected. Can be used for treating body injury caused by virus reproduction and immune reaction after infection of novel coronavirus. The formula and the using method thereof can also effectively remove various germs and viruses attached to the mask, and the mask can be repeatedly used after being smoked.

The technical scheme of the invention is as follows:

a pure traditional Chinese medicine formula for carrying out tracking targeted inactivation and infection inhibition aiming at novel coronavirus propagation mechanism kinetics comprises the following raw materials in parts by weight: 20-45% of rhizoma atractylodis, 10-35% of folium artemisiae argyi, 10-18% of herba agastaches, 8-15% of orange peel, 8-15% of platycodon grandiflorum and 5-15% of perilla leaves. The manufacturing method comprises the following steps: all the raw materials are prepared into 80-150-mesh powder and uniformly mixed according to a proportion.

As a preferred scheme, dry traditional Chinese medicine raw materials with fragrance and containing volatile oil, such as sandalwood, benzoin, rose, borneol, agilawood and the like, can be added into the original formula according to different fragrance types or different associated reaction symptoms to be used as fragrance types for blending. Wherein the Borneolum Syntheticum has effect of promoting mucosa absorption, and is especially suitable for people with weak respiratory system.

The main functions and efficacies of various raw materials related to the invention and the functions in the action mechanism are as follows:

rhizoma atractylodis: as early as in the Han dynasty, Zhang Zhongjing says that rhizoma Atractylodis can avoid all bad breath, and Ming Dynasty Li Shizhen records that rhizoma Atractylodis can remove bad breath, diseases and senile denier, and tends to burn rhizoma Atractylodis to avoid pathogenic qi when entering home, so that the epidemic diseases are used more frequently. The record of Zhang shan Lei (materia Medica) in recent times: cang Zhu is fragrant and can avoid foul smell and surpass the qi of four seasons, so it is used for epidemic diseases. Most effectively removing foul and foul smell. In the area of haze, it is advisable to burn the material in a long-term open room and then live in the house. According to modern researches, rhizoma atractylodis has the functions of sterilizing, inhibiting and inactivating viruses.

Folium artemisiae argyi: fumigating moxa is a common method used by folks for eliminating dampness and disinfection since ancient times, and its efficacy is well known. Modern medical research has shown that: the essential oil component (fragrance component) in folium Artemisiae Argyi has effects of inhibiting or killing various pathogenic bacteria and viruses. According to the records of the monograph of the Chinese mugwort leaf: the antibacterial and antiviral test of Shanghai et al on the incense for disinfecting prepared from folium Artemisiae Argyi as main ingredient shows that folium Artemisiae Argyi (mainly containing essential oil) has effect in killing pneumococcus and influenzae bacillus, and shows that folium Artemisiae Argyi has effect in preventing influenza.

And (3) jojoba leaf: the volatile oil in herba Agastaches has effects of stimulating gastric mucosa, promoting gastric secretion, and promoting digestion. The flavonoids in herba Agastaches have antiviral effect, and the components separated from herba Agastaches can inhibit growth and reproduction of virus as pathogen in digestive tract and upper respiratory tract.

The invention can treat diarrhea caused by virus infection to intestines and stomach, and can inhibit the growth and reproduction of virus in respiratory tract and digestive tract.

Orange peel: the formula of the invention has the functions of regulating qi, freeing lung and stimulating appetite, and can achieve the effect of assisting the recovery of lung function.

Balloon flower: the invention plays the roles of dispersing lung qi and eliminating phlegm.

And (3) perilla leaves: it has effects in relieving asthma, promoting perspiration, relieving cough, invigorating stomach, promoting urination, relieving pain, tranquilizing mind, removing toxic materials, and eliminating dampness. The invention can also relieve tachypnea symptoms of patients infected with virus.

The invention has the advantages of medical effect and theory:

1. the same pathway of viral transmission infection is used as an interventional approach for accurate tracking and suppression of inactivation. The using method comprises the following steps: all the raw materials are prepared into a powder velvet shape according to the proportion: after being mixed evenly, the mixture is put into a metal or porcelain container to be ignited for air aromatherapy, and viruses existing in the air and viruses deposited on the surface of an object are inactivated.

2. When a human body breathes, the virus enters the respiratory system along with the inhaled air, and the virus inhaled into the respiratory system is inactivated, so that the injury or extra burden aggravated immunity failure of human organ tissues caused by taking a large amount of external disinfection medicines in the treatment process is avoided. The effective components of the medicine can effectively clean and disinfect the respiratory system.

3. According to the immune response of the novel coronavirus infection, the folium artemisiae argyi, the ageratum, the orange peel, the platycodon grandiflorum and the perilla leaf in the formula contain a large amount of volatile oil of traditional Chinese medicines, so that corresponding interventional adjuvant therapy can be performed, the effects of ventilating the lung, reducing phlegm and eliminating dampness are achieved, the infection symptoms are rapidly improved, the virus is accelerated to be discharged out of a body, and the basic disease attack caused by the infection response is avoided, so that the life risk is avoided. The volatile oil after combustion volatilizes more thoroughly, can not only inhibit or kill bacteria and viruses in the indoor environment, but also can be distributed in the oral and nasal respiratory tracts of people, can inactivate pathogenic bacteria and viruses entering the oral and nasal respiratory tracts of people, and can form a micro-membrane barrier in the oral and nasal cavities to prevent the invasion of pathogenic bacteria and viruses.

4. The incense or the active ingredients of the raw materials can be prepared into different forms, and the active ingredients are mixed according to the proportion of the components and then are matched with an atomizer and a humidifier for use, so that the incense or the active ingredients can be used for purifying and disinfecting daily indoor air.

All the raw material effects in the invention are clearly stated in the medical academic papers and the practical cases are proved. In the practical process of the inventor, the aromatherapy powder prepared by the formula is ignited for the first time, so that the effects of ventilating the lung and clearing damp are obvious, the air quality of the using environment is improved along with the increase of the using times, the yang qi of a human body is improved, and the immunity of the human body is enhanced. The formula related in the invention is prepared by innovating according to the specific case of ancient Chinese traditional medicine for treating epidemic diseases, is especially suitable for inactivating new coronavirus to block transmission and infection, and the effective components contained in the formula herbal medicines have obvious relieving and improving effects on pneumonia caused by virus infection.

Detailed description of the preferred embodiments

20-45% of rhizoma atractylodis, 10-35% of folium artemisiae argyi, 10-18% of herba agastaches, 8-15% of orange peel, 8-15% of platycodon grandiflorum and 5-15% of perilla leaf

The implementation mode comprises two modes of directly igniting the raw materials by making the raw materials into powder, or mixing the raw material extracting solution according to the proportion to prepare various aromatherapy or adding the raw material extracting solution into an atomizer, a humidifier and the like in the form of extracting solution to be used as daily indoor air purification, disinfection and health preservation aromatherapy, wherein the proportion and the proportion of various components are within the range of the percentage using amount and are not limited to the components and the proportion in the embodiment.

The first embodiment is as follows: taking 35% of rhizoma atractylodis, 18% of folium artemisiae argyi, 16% of herba agastaches, 15% of orange peel, 8% of platycodon grandiflorum and 8% of folium perillae, preparing into powder with 100 meshes, uniformly mixing, and putting a proper amount of the powder into an incense burner according to the space size to be ignited and fully burning the raw material powder when in use.

Example two: preparing 100-mesh powder from 35% of rhizoma atractylodis, 12% of folium artemisiae argyi, 14% of herba agastaches, 12% of orange peel, 12% of platycodon grandiflorum, 5% of perilla leaf, 8% of sandalwood and 2% of borneol, uniformly mixing to prepare the incense powder, and putting a proper amount of the incense powder into an incense furnace according to the space size to be ignited and fully burn the raw material powder when in use.

Example three: the preparation method comprises the steps of preparing 100-mesh powder from 35% of rhizoma atractylodis, 14% of folium artemisiae argyi, 12% of herba agastaches, 15% of orange peel, 10% of platycodon grandiflorum, 10% of perilla leaf and 4% of benzoin, uniformly mixing the powder to prepare the incense powder, and putting a proper amount of the incense powder into an incense furnace according to the space size to be ignited and fully burning the raw material powder when the incense powder is used.

Example four: the raw material aromatic oil is prepared by the following steps: the essential oil is prepared by uniformly mixing 35% of rhizoma atractylodis, 15% of folium artemisiae argyi, 13% of herba epimedii, 13% of orange peel, 12% of platycodon grandiflorum, 5% of perilla leaves, 5% of rose and 2% of borneol, and is put into an atomizer or a humidifier when in use. The aromatherapy essential oil can also be prepared into a washing and caring product for cleaning skin.

The above embodiments are not limited to ingredient combinations, sandalwood, benzoin, rose, borneol and the like can be added alternatively. The using method is not limited to the preparation of powder, and the incense stick can be processed into incense with certain shape, such as a coil incense or a tower incense. Or mixing all the raw materials according to a certain proportion, and matching with an atomizer or a humidifier.

Claims

1. The invention relates to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation, in particular to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation aiming at novel dynamics of coronavirus transmission mechanism. The main raw materials are as follows: rhizoma atractylodis, folium artemisiae argyi, herba agastaches, orange peel, platycodon grandiflorum and folium perillae.

2. According to claim 1: the invention relates to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation, in particular to a pure traditional Chinese medicine formula for inhibiting infection by tracking targeted inactivation aiming at novel dynamics of coronavirus transmission mechanism. The main raw materials are as follows: rhizoma atractylodis, folium artemisiae argyi, herba agastaches, orange peel, platycodon grandiflorum and folium perillae. When the formula is used, the traditional Chinese medicine raw materials with aromatic odor, such as sandalwood, benzoin, rose, borneol and the like, can be added into the original formula according to the using environment, so that different fragrance types can be prepared.