CN111714555A - Traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, disinfection method and device - Google Patents

Traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, disinfection method and device Download PDF

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CN111714555A
CN111714555A CN202010731053.6A CN202010731053A CN111714555A CN 111714555 A CN111714555 A CN 111714555A CN 202010731053 A CN202010731053 A CN 202010731053A CN 111714555 A CN111714555 A CN 111714555A
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chinese medicine
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张跃
陈挺松
韩涛
李京
张燕明
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Abstract

The invention belongs to the technical field of traditional Chinese medicine disinfection, and particularly relates to a traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, and a disinfection method and a disinfection device. The traditional Chinese medicine disinfection composition comprises folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts by weight. The sachet is made or steamed, and the volatile matter is used for effectively sterilizing and disinfecting. The invention provides a traditional Chinese medicine disinfection composition aiming at the pathogenesis characteristics and pathogenesis of novel coronavirus pneumonia, wherein seven medicines are aromatic and pungent, have the effects of activating spleen and dispelling dampness, and are mainly used for dredging channels and collaterals, opening fornix and penetrating bones through the action of aromatic medicines, dredging viscera and channels and collaterals systems through oral and nasal inhalation and skin and acupoint absorption, and integrally regulating a human body, so that the effects of avoiding dirt and preventing diseases are exerted, meanwhile, the traditional Chinese medicinal materials are low in price, and the current situation of insufficient medical protection resources in partial regions can be relieved by using the traditional Chinese medicines for fumigation and disinfection.

Description

Traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, disinfection method and device
Technical Field
The invention belongs to the technical field of traditional Chinese medicine disinfection, and particularly relates to a traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, and a disinfection method and a disinfection device.
Background
A novel coronavirus pneumonia (Corona Virus Disease 2019, COVID-19) which is outbreaked in Hubei Wuhan in 2019 is a newly discovered respiratory system Disease with strong infectivity, and clinically, fever, dry cough and hypodynamia are mainly shown. The clinical protocols for pneumonia infected by novel coronavirus (trial seventh edition), promulgated by the national health committee at 3.3.2020, indicate that the infection source is mainly the patients infected by the novel coronavirus at present, and asymptomatic infectors may also become infection sources and are generally susceptible to the crowd. In addition, under the background of COVID-19 aggregation onset and transmission through contact, air spray and possibly aerosol, the prevention and treatment become the key and difficult points in clinical and basic research at present.
The decision power of epidemic prevention and epidemic prevention is the masses, and hospitals, families and communities are the maximum battlefield for resisting epidemic situations at present. When a patient sneezes and coughs, a lot of tiny droplets are ejected from nostrils and oral cavity, and pathogenic microorganisms contained in the droplets are dried to easily form bacterial dust and droplet particle bacteria smaller than 5 mu m, and can float in the air for a long time and spread for a long distance to cause the susceptible patient to be infected, so that the adoption of an air disinfection method in hospitals, families and communities is very important, and the occurrence of cross infection can be obviously prevented. The current protection and disinfection measures mainly comprise steaming white vinegar, spraying alcohol, 84 disinfection solution and the like. Although the white vinegar has the sterilization and disinfection effects to a certain extent, the home wants to only cup the salary by steaming the white vinegar for disinfection, the substantial effect is not large, the true sterilization effect is difficult to achieve, and the respiratory tract can be stimulated. 75% alcohol has a good bactericidal effect but is not suitable for direct application to the body or large area applications, otherwise deflagration may occur. The concentration of the chlorine-containing disinfection solution such as 84 disinfection solution is usually between 5% and 10%, the concentration is too high, the irritation is too strong, the injury to human tissues and organs is easy to cause, and the disinfection solution can be used only by diluting the disinfection solution by 100-200 times.
The concept of 'preventive treatment of disease' in traditional Chinese medicine is fully exerted in the prevention and treatment of the epidemic situation of the new coronary pneumonia, and the immunity of the people is improved, the proportion of susceptible people is reduced, and the symptoms of the susceptible people are relieved by adjusting the yin, the yang and the secret of the human body. The research prospect of the way of blocking virus transmission by traditional Chinese medicine fumigation is very wide. Meanwhile, the traditional Chinese medicinal materials are convenient to obtain, relatively low in price and relatively sufficient in national reserves, the medical cost can be reduced by applying the traditional Chinese medicinal materials, the current situation of protecting medical resources from shortage is relieved, and the disinfection efficiency is improved. Therefore, the traditional Chinese medicine disinfection formula and the method can be widely applied to epidemic prevention in a plurality of scenes of medical institutions, families and communities, are beneficial to cutting off the transmission path, achieve the purpose of isolating viruses and better assist in epidemic situation defense.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, a disinfection method and a disinfection device.
The invention is realized in such a way, and provides a traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, which comprises folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts by weight.
Also provides a traditional Chinese medicine sachet for preventing and treating the new coronavirus pneumonia, which comprises the traditional Chinese medicine disinfection composition.
The traditional Chinese medicine disinfection method for preventing and treating the new coronavirus pneumonia is characterized by taking the traditional Chinese medicine disinfection composition in equal parts by weight, adding a certain mass of water, heating to generate steam, and disinfecting by using traditional Chinese medicine volatile matters carried in the steam.
The traditional Chinese medicine disinfection device for preventing and treating the new coronavirus pneumonia comprises a box body, wherein the box body is divided into a heating box and an atomizing box by a partition plate, a heating plate is arranged in the heating box, an openable cover body is arranged at the upper part of the heating box, a communicating channel is arranged between the upper part of the heating box and the lower part of the atomizing box, an atomizing sheet is arranged in the atomizing box, and a spraying hole is formed in the upper end of the atomizing box;
the switch is externally connected with a plug and controls the start and stop of the work of the heating plate and the atomizing sheet;
the Chinese medicinal disinfectant composition is placed into a heating box, is soaked in water for a period of time, and then can be cooked and disinfected by steam atomization.
Further, a liquid level sensor is arranged on the inner wall of the heating box on the upper side of the heating plate, a controller is arranged on the surface of the box body, the liquid level sensor is electrically connected with the controller, and the controller is electrically connected with the switch.
Further, the heating plate is arranged at the position of one fourth to one third of the height of the inner wall of the heating box from bottom to top.
Furthermore, the spraying holes are distributed on the box body at the upper end of the atomizing box.
Furthermore, the spraying hole is connected with a flexible pipe, and the other end of the flexible pipe is a shower type nozzle.
Furthermore, the connecting channel comprises an external section and an internal section, the external section is arranged at the bottom of the heating box from the upper part of the heating box to the lower part of the heating box to form a handle structure, one end of the internal section is connected with the external section, and the other end of the internal section is connected with the atomizing box.
Further, the atomizing sheet is provided with a plurality of rows, and the atomizing sheets on each row are inclined upwards at the same angle.
Compared with the prior art, the invention has the advantages that:
1. based on the clinical practice that traditional Chinese medicines are applied to controlling SARS, influenza A H1N1 and the like, the traditional Chinese medicine disinfection composition is provided aiming at the pathogenesis characteristics and pathogenesis of novel coronavirus pneumonia, seven medicines are aromatic and pungent, have the effects of activating spleen and dispelling dampness, mainly utilize the functions of aromatic medicines of clearing and activating the channels and collaterals, opening the fornix and penetrating bones, and achieve the effects of avoiding dirt and preventing diseases by oral and nasal inhalation and skin and acupoint absorption, dredging the viscera and channels and collaterals system and integrally regulating the human body, meanwhile, the traditional Chinese medicines are low in price, and the current situation that medical protection resources in partial areas are insufficient can be relieved by using traditional Chinese medicines for fumigation;
2. the traditional Chinese medicine disinfection composition is used as a raw material to be made into a sachet which is worn on a person to play a role in disinfecting the personal surrounding environment;
3. the Chinese medicinal sterilizing composition is cooked, and distilled volatile matter is used for sterilizing air in the environment, so that volatile oil and effective sterilizing components of Chinese medicaments can be completely dispersed into the air along with steam during atomization, dust is precipitated, the sterilizing effect is achieved, and the air is purified. The traditional Chinese medicine fumigation solution is a substitute of a conventional disinfection method to a certain extent, is not only suitable for air disinfection in hospitals, but also suitable for household disinfection, has practical value for patients isolated at home, is beneficial to cutting off a propagation path, reduces the waste of medical materials, can effectively avoid the occurrence of adverse reactions such as air pollution and the like, fully exerts the effects of traditional Chinese medicine fumigation on strengthening vital qi to eliminate pathogenic factors and restoring yang to prevent diseases, provides basis for reasonable and standard application and popularization of traditional Chinese medicine fumigation, and is beneficial to promoting the development of the prevention and treatment of new crown pneumonia epidemic situation to a good direction;
4. aiming at the disinfection method of the invention, the disinfection device is matched, thus being easy to manufacture and convenient to carry.
Drawings
FIG. 1 is a schematic diagram of a traditional Chinese medicine disinfection device in an embodiment 4 of the present invention;
FIG. 2 is a schematic diagram of a disinfection apparatus for traditional Chinese medicine according to an embodiment 5 of the present invention;
fig. 3 is a diagram showing a connection relationship of control components.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Examples 1,
The traditional Chinese medicine sachet for preventing and treating the new coronavirus pneumonia comprises a traditional Chinese medicine disinfection composition for preventing and treating the new coronavirus pneumonia, namely folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts by weight. Before making the sachet, the seven traditional Chinese medicines are ground into fine powder and then uniformly stirred, which is helpful for releasing volatile matters.
Folium Artemisiae Argyi, radix bupleuri, rhizoma Atractylodis, radix Et rhizoma Rhei, rhizoma Et radix Notopterygii, herba asari, and fructus evodiae, and the herbs can enter six meridians of Taiyang, Yangming, Shaoyang, Taiyin, Shaoyin, and Jueyin. Wherein notopterygium root, radix bupleuri and fructus evodiae rise mainly, rheum officinale, rhizoma atractylodis and asarum herb descend mainly, notopterygium root, rheum officinale and radix bupleuri descend mainly, and evodia rutaecarpa, rhizoma atractylodis and asarum herb enter mainly and are matched to regulate qi activity of a human body to ascend and descend, so that dampness, cold, heat and stasis can be dissipated, namely, the phenomenon that the atmosphere changes one and the gas is dissipated is avoided, and the medicine can play a role in treating the core pathogenesis of new crown pneumonia, such as dampness, heat, toxicity, stasis and deficiency. The six medicines are divided into the upper, middle and lower triple energizers to regulate the six meridians, so that the qi movement is smooth to ascend, descend and come out, pathogenic qi is eliminated, the upper, middle and lower triple energizers are cleared away, and the pathogenic qi gives way, thereby embodying the overall concept of traditional Chinese medicine treatment. Folium artemisiae argyi is bitter and pungent in taste, warm in nature and enters liver, spleen and kidney meridians, fragrant and warm in nature, and can rise and descend. Has effects of removing toxic substances, eliminating pathogenic factors, removing dirt, warming channels, dispelling cold, strengthening yang, and invigorating yang. The aromatic medicine can stimulate the release of neurotransmitter and increase the blood flow of prefrontal cortex, thereby improving the symptoms of depression and anxiety, and has the characteristics of quick response and long maintenance time.
Examples 2,
The disinfectant for preventing and treating the new coronavirus pneumonia is provided, wherein the raw medicinal materials comprise folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts by weight.
The disinfectant is prepared by mixing the volatile oils of seven Chinese medicines and adding common matrix of disinfectant, wherein the volatile oils of the Chinese medicines are obtained by steam distillation.
Examples 3,
The traditional Chinese medicine disinfection method for preventing and treating the new coronavirus pneumonia is characterized by taking traditional Chinese medicine disinfection compositions with the same parts by weight: folium Artemisiae Argyi, bupleuri radix, rhizoma Atractylodis, radix et rhizoma Rhei, Notopterygii rhizoma, herba asari and fructus evodiae, adding a certain amount of water, heating to generate steam, and sterilizing with Chinese medicinal volatile substances carried in the steam.
The traditional Chinese medicine fumigation method is an effective air disinfection method. Through the full volatilization of the volatile oil components, the composition can not only inhibit or kill bacteria and viruses in the air, but also can be distributed in the nasal respiratory tract of a human body to kill the bacteria or viruses entering the oral and nasal respiratory tract of the human body, and a microfilm barrier is formed in the oral and nasal parts to prevent the invasion of influenza viruses. The main pathogenic factor of the new coronary pneumonia is novel coronavirus, and pharmacological research finds that the medicine in the traditional Chinese medicine fumigation and disinfection instrument has the effects of resisting influenza virus and improving pneumonia symptoms.
Examples 4,
Referring to fig. 1, a traditional Chinese medicine disinfection device for preventing and treating new coronavirus pneumonia is provided, which comprises a box body, wherein the box body is divided into a heating box 1 and an atomizing box 2 by a partition plate, a heating plate 3 is arranged inside the heating box 1, an openable cover body 4 is arranged at the upper part of the heating box 1, a communicating channel 5 is arranged at the upper part of the heating box 1 and the lower part of the atomizing box 2, an atomizing sheet 6 is arranged in the atomizing box 2, and an atomizing hole 7 is arranged at the upper end of the atomizing box 2; the device further comprises a switch 8, the switch 8 is externally connected with a plug, and the switch 8 controls the start and stop of the work of the heating plate 3 and the atomization sheet 6.
In order to prevent dry burning, as an improvement of the technical scheme, a liquid level sensor 9 is arranged on the inner wall of the heating box 1 at the upper side of the heating plate 3, a controller 10 is arranged on the surface of the box body, the liquid level sensor 9 is electrically connected with the controller 10, and the controller 10 is electrically connected with the switch 8.
Preferably, the heating plate 3 is arranged at a position from one fourth to one third of the height of the inner wall of the heating box 1 from bottom to top.
The spraying holes 7 are distributed on the box body at the upper end of the atomizing box 2.
The connecting channel 5 comprises an external section 501 and an internal section 502, the external section 501 extends from the upper part of the heating box 1 to the lower part of the heating box 1 to form a handle structure, the internal section is arranged at the bottom of the heating box 1, one end of the internal section is connected with the external section 501, the other end of the internal section is connected with the atomizing box 2, and the internal section 502 extends into the atomizing box 2 and is upwards connected with a spray head structure.
The atomizing plate 6 is provided with a plurality of rows, and the atomizing plates 6 on each row are inclined upwards at the same angle.
When the device is used for air disinfection, equal parts of folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae are firstly put into the heating box 1, and in order to prevent traditional Chinese medicines from entering the atomizing box 2 along with steam, the traditional Chinese medicine components are not ground into fine pieces and are only in a sheet shape. Put into heating cabinet 1 and then soak the certain time earlier, then open the switch, hot plate 3 begins to heat it and boils promptly, along with the going on of heating, slowly has the volatile substance of steam area each traditional chinese medicine to enter into atomizer box 2, and the atomizing piece atomizes steam, releases in the external environment through spray hole 7.
In order to guarantee sufficient soaking time, the switch 8 can be set into two stages, the switch for opening the heating plate 3 is rotated for one circle, the switch for opening the atomizing sheet 6 is rotated for two circles, the heating plate 3 is firstly opened during use, heating soaking is carried out, after steam comes out from the spraying holes 7, the switch for opening the atomizing sheet 6 is rotated, and the steam is atomized.
Examples 5,
The difference from the embodiment 4 is that 1 spraying hole 7 is provided, the spraying hole 7 is connected with a flexible pipe 11, and the other end of the flexible pipe 11 is a shower type nozzle 12.
Mainly solves the problem that the disinfection space of the embodiment 4 is limited, and the shower type spray head 12 can be moved at will.
Examples 6,
Sterilizing the pneumonia patient ward, and comparing the traditional Chinese medicine fumigation group with the alcohol disinfection group in terms of the number of bacteria in the room before and after disinfection.
4-compartment ward (between three persons, 40 m) for patients receiving pneumonia treatment in a certain hospital2One patient, but only one patient) was disinfected and the ward was set at 1: 1, the traditional Chinese medicine fumigation ward is randomly divided into a traditional Chinese medicine fumigation ward and a conventional disinfection ward, the traditional Chinese medicine fumigation ward is disinfected by the traditional Chinese medicine disinfection device in the embodiment 3 or the embodiment 4, the traditional Chinese medicine components comprise folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts, and the conventional disinfection ward is 75 percentAnd (5) disinfecting with alcohol. Bacterial colony counts before and after sterilization of the two groups of rooms were compared. Sampling the air bacteria sedimentation rate before and after sterilizing the room respectively, carrying out bacteria culture and bacteria identification, observing the action time and the sterilization effect of the two groups, and collecting two room air samples according to a standard sedimentation method after sterilizing the room for 1, 2 and 3 hours by adopting corresponding methods respectively for the two groups. Culturing in a bacteria room for 48h, and observing the result. The number of bacteria contained per cubic meter was calculated according to the austenite formula.
The results of the experiment are shown in the following table:
TABLE 1 comparison of air bacterial colony counts (cfu/cm) before and after Disinfection in two groups of wards3,x±s)
Figure BDA0002603186800000071
Injecting, wherein bacterial colony counts before and after the two groups of wards are disinfected are compared, the bacterial colony count between the F groups is 11.487, and P is less than 0.001; f, different time points are 83.368, and P is less than 0.001; and F is 121.492, and P is less than 0.001.
The satisfaction survey of patients shows that the patients in the traditional Chinese medicine fumigation group wards have better treatment experience and are willing to accept fumigation disinfection, while the patients in the alcohol disinfection group have more opinions on the problems of strong alcohol smell and the like and have the psychological resistance to alcohol disinfection.
This experiment suggestion inferior traditional chinese medicine fumigation appearance has better disinfection effect to the alcohol disinfection, and pneumonia patient is more accepted, has efficiency such as reinforcing experience of seeking medical advice.

Claims (10)

1. The traditional Chinese medicine disinfection composition for preventing and treating the new coronavirus pneumonia is characterized by comprising folium artemisiae argyi, radix bupleuri, rhizoma atractylodis, rheum officinale, notopterygium root, asarum and fructus evodiae in equal parts by weight.
2. The traditional Chinese medicine sachet for preventing and treating the new coronavirus pneumonia, which is characterized by comprising the traditional Chinese medicine disinfection composition of claim 1.
3. A traditional Chinese medicine disinfection method for preventing and treating new coronavirus pneumonia is characterized in that a certain mass of water is added into the traditional Chinese medicine disinfection composition according to claim 1 in equal parts by mass, steam is generated after heating, and traditional Chinese medicine volatile matters carried in the steam are utilized for disinfection.
4. The traditional Chinese medicine disinfection device for preventing and treating the new coronavirus pneumonia is characterized by comprising a box body, the box body is divided into a heating box (1) and an atomizing box (2) by a partition plate, a heating plate (3) is arranged inside the heating box (1), an openable cover body (4) is arranged at the upper part of the heating box (1), a communicating channel (5) is arranged at the upper part of the heating box (1) and the lower part of the atomizing box (2), an atomizing sheet (6) is arranged in the atomizing box (2), and a spraying hole (7) is formed in the upper end of the atomizing box (2);
the device also comprises a switch (8), the switch (8) is externally connected with a plug, and the switch (8) controls the start and stop of the work of the heating plate (3) and the atomization sheet (6);
the Chinese medicinal disinfectant composition according to claim 1 is placed in a heating chamber (1), and is soaked in water for a period of time to be cooked, and is sterilized by steam atomization.
5. The traditional Chinese medicine disinfection device for preventing and treating new coronavirus pneumonia according to claim 4, wherein a liquid level sensor (9) is arranged on the inner wall of the heating box (1) at the upper side of the heating plate (3), a controller (10) is arranged on the surface of the box body, the liquid level sensor (9) is electrically connected with the controller (10), and the controller (10) is electrically connected with the switch (8).
6. The traditional Chinese medicine sterilizing device for preventing and treating new coronavirus pneumonia in claim 4, characterized in that the heating plate (3) is arranged at the position of the height of the inner wall of the heating box (1) from one fourth to one third from the bottom to the top.
7. The traditional Chinese medicine disinfection device for preventing and treating new coronavirus pneumonia as claimed in claim 4, wherein a plurality of spray holes (7) are arranged and distributed on the box body at the upper end of the atomization box (2).
8. The traditional Chinese medicine disinfection device for preventing and treating new coronavirus pneumonia as claimed in claim 4, wherein the spraying hole (7) is connected with a flexible pipe (11), and the other end of the flexible pipe (11) is provided with a shower type nozzle (12).
9. The traditional Chinese medicine disinfection device for preventing and treating new coronavirus pneumonia according to claim 4, wherein the connecting channel (5) comprises an external section (501) and an internal section (502), the external section (501) is arranged from the upper part of the heating box (1) to the lower part of the heating box (1) to form a handle structure, the internal section is arranged at the bottom of the heating box (1), one end of the internal section is connected with the external section (501), the other end of the internal section is connected with the atomization box (2), and the internal section (502) extends into the atomization box (2) and is upwards connected with a nozzle structure.
10. The traditional Chinese medicine sterilizing device for preventing and treating new coronavirus pneumonia, as claimed in claim 4, characterized in that the atomizing plate (6) is provided with a plurality of rows, and the atomizing plates (6) on each row are inclined upwards at the same angle.
CN202010731053.6A 2020-07-27 2020-07-27 Traditional Chinese medicine disinfection composition for preventing and treating new coronavirus pneumonia, disinfection method and device Withdrawn CN111714555A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112289378A (en) * 2020-11-02 2021-01-29 博奥生物集团有限公司 Method for determining Chinese medicinal composition and method for determining medicinal effect thereof
CN112687370A (en) * 2020-12-28 2021-04-20 博奥生物集团有限公司 Electronic prescription generation method and device and electronic equipment
CN113599442A (en) * 2021-07-14 2021-11-05 青海济生恒中医药高新科技有限公司 Incense for avoiding plague and its preparation method
CN116650572A (en) * 2023-07-21 2023-08-29 无锡市中医医院 Application of traditional Chinese medicine composition volatile oil in preparation of medicine for preventing or treating acute lung injury

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
梁雪: "苍术艾叶桉叶联合熏蒸在儿科病房空气消毒中的应用", 《护理实践与研究》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112289378A (en) * 2020-11-02 2021-01-29 博奥生物集团有限公司 Method for determining Chinese medicinal composition and method for determining medicinal effect thereof
CN112687370A (en) * 2020-12-28 2021-04-20 博奥生物集团有限公司 Electronic prescription generation method and device and electronic equipment
CN112687370B (en) * 2020-12-28 2023-12-22 北京博奥晶方生物科技有限公司 Electronic prescription generation method and device and electronic equipment
CN113599442A (en) * 2021-07-14 2021-11-05 青海济生恒中医药高新科技有限公司 Incense for avoiding plague and its preparation method
CN116650572A (en) * 2023-07-21 2023-08-29 无锡市中医医院 Application of traditional Chinese medicine composition volatile oil in preparation of medicine for preventing or treating acute lung injury

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