CN115969789A - Oral and nasal spray of epidemic prevention and sterilization qingkailing composition and preparation method thereof - Google Patents
Oral and nasal spray of epidemic prevention and sterilization qingkailing composition and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses an oral and nasal spray of a qingkailing composition for epidemic prevention and sterilization and a preparation method thereof, wherein the oral and nasal spray comprises a spray bottle and the qingkailing composition, and the qingkailing composition is prepared from the following raw materials: honeysuckle extract, baicalin, isatis root extract, thyme extract, purple root extract, sage extract, peony root extract, mulberry leaf extract, hop extract and clove oil. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition is prepared by compounding honeysuckle extract, baicalin and isatis root extract with thyme extract, violet root extract, sage extract, peony root extract, mulberry leaf extract, hop extract and other raw materials with sterilization effects, is applied to the oral and nasal cavities and can continuously kill germs sucked into the air, and a protective net is arranged at the oral and nasal cavities to protect the health of a human body. The invention has strong killing effect on various common pathogenic bacteria and has inhibiting effect on the transmission of new corona virus.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine application, in particular to an oral and nasal spray of a qingkailing composition for epidemic prevention and sterilization and a preparation method thereof.
Background
QING KAI LING is an improved preparation of ANG GONG NIU HUANG WAN (calculus bovis Bolus pill) of classic formula, and has effects of clearing heat and detoxicating, eliminating phlegm, dredging collaterals, and inducing resuscitation. The traditional Chinese medicine composition is mainly clinically used for treating patients suffering from exogenous wind-heat and high fever caused by internal exuberance of fire toxin, dysphoria, sore throat, crimson tongue, yellow fur and rapid pulse, upper respiratory infection, viral cold, acute suppurative tonsillitis, acute pharyngitis, acute tracheitis, high fever and other diseases. Wherein flos Lonicerae and radix Isatidis have antibacterial and bactericidal effects on pneumococcus, meningococcus, pseudomonas aeruginosa, mycobacterium tuberculosis, shigella dysenteriae, and Streptococcus mutans, and have inhibitory effects on influenza virus, orphan virus, herpesvirus, and leptospira. The nose and mouth are used as a respiratory system of a human body, the contact with the environment is inevitable, a plurality of infectious diseases are transmitted through air, spray or aerosol, the noise is silent and unconscious, the prevention is not competent, the breathing is not smooth after wearing the mask for a long time, and the protection effect is not satisfactory due to the inconsistent quality of the mask, so the qingkailing composition nose and mouth spray for epidemic prevention and sterilization and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a qingkailing composition oral-nasal spray for epidemic prevention and sterilization and a preparation method thereof.
In order to achieve the purpose, the invention provides the following technical scheme:
the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition comprises a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials:
honeysuckle extract, baicalin, isatis root extract, thyme extract, purple root extract, sage extract, peony root extract, mulberry leaf extract, hop extract and clove oil.
Further, the qingkailing composition is prepared from the following raw materials in parts by weight:
14-22 parts of honeysuckle extract, 1.2-1.9 parts of baicalin, 8-14 parts of isatis root extract, 6-12 parts of thyme extract, 4-8 parts of violet root extract, 3-5 parts of sage extract, 1-3 parts of peony root extract, 2-5 parts of mulberry leaf extract, 2-3 parts of hop extract and 0.6-1.2 parts of clove oil.
Further, the qingkailing composition is prepared from the following raw materials in parts by weight:
16 parts of honeysuckle extract, 1.9 parts of baicalin, 12.8 parts of isatis root extract, 6.6 parts of thyme extract, 7.5 parts of violet root extract, 3 parts of sage extract, 2.7 parts of peony root extract, 4.6 parts of mulberry leaf extract, 2 parts of hop extract and 1.1 parts of clove oil.
Further, the qingkailing composition is prepared from the following raw materials in parts by weight:
18 parts of honeysuckle extract, 1.5 parts of baicalin, 10.6 parts of isatis root extract, 9.2 parts of thyme extract, 6.2 parts of violet root extract, 4 parts of sage extract, 2.2 parts of peony root extract, 3.3 parts of mulberry leaf extract, 2.6 parts of hop extract and 0.9 part of clove oil.
Further, the qingkailing composition is prepared from the following raw materials in parts by weight:
22 parts of honeysuckle extract, 1.2 parts of baicalin, 8.4 parts of isatis root extract, 12 parts of thyme extract, 5 parts of radix violae extract, 5 parts of sage extract, 1.4 parts of peony root extract, 2.4 parts of mulberry leaf extract, 3 parts of hops extract and 0.7 part of clove oil.
Further, the preparation method of the honeysuckle extract comprises the following steps:
(1) Pulverizing fresh flos Lonicerae with pulverizer to obtain flos Lonicerae particles with particle size of 20-40 mesh;
(2) Adding a solvent, and adding ethanol into the arrowhead particles to obtain a mixed solution, wherein the mass ratio of the honeysuckle particles to the ethanol is 1:8-10 ℃, the temperature is 18-25 ℃, and the soaking time is 1.5-2h;
(3) Performing enzymolysis extraction, namely adding cellulase into the mixed solution, wherein the weight ratio of the cellulase to the raw materials is 0.5%, the pH value is 5.0, the temperature is kept at 53 ℃, and the enzymolysis time is 3.0h;
(4) Performing centrifugal separation, namely performing centrifugal separation on the enzymolysis liquid obtained in the step (3), and centrifuging 10-15min in a centrifugal machine with the rotating speed of 2000-2500rpm to obtain clear liquid and honeysuckle residues;
(5) Heating to inactivate enzyme, heating the clear liquid obtained in step (4) to inactivate enzyme, and separating solvent to obtain flos Lonicerae extract at 95-100 deg.C for 10-15min.
Furthermore, the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition has the particle size distribution that the percentage of the fog drops with the particle size of 2-5 mu m in the total volume of the fog drops is more than 75%.
Further, the product can be used for disinfecting and inhibiting bacteria in oral and nasal cavities, and preventing invasion of bacteria or virus.
The preparation method of the epidemic prevention antibactericide qingkailing composition oral-nasal spray comprises the following steps:
s1, mixing a honeysuckle extract, an isatis root extract, a thyme extract, a radix rhois extract, a sage extract, a peony root extract, a mulberry leaf extract and a hop extract at normal temperature, and homogenizing;
s2, adding baicalin and clove oil into the mixed solution, and slowly stirring until the mixture is homogeneous;
and S3, performing sampling inspection, and filling the qualified product into a spray bottle.
Furthermore, in S1 and S2, the stirring speed is 20-30r/min.
Compared with the prior art, the invention has the beneficial effects that: the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition and the preparation method thereof have the following advantages:
the raw materials with bactericidal effect, such as honeysuckle extract, baicalin, isatis root extract, thyme extract, purple root extract, sage extract, peony root extract, mulberry leaf extract, hops extract and the like, are compounded to prepare the medicine which is applied to the mouth and nose and can continuously kill germs inhaled into the air, and a protective net is arranged at the mouth and nose to protect the health of a human body.
The thyme extract, the mulberry leaf extract and the hop extract are added, so that the slightly bitter taste of the qingkailing spray is improved, the overall taste and smell are more easily accepted by users, the invention has stronger killing effect on various common germs and also has inhibiting effect on the spread of new coronavirus.
The raw materials are all pure plant sources, so that the use safety is high, and the sterilization effect is good.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides the following technical scheme:
the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition comprises a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials:
honeysuckle extract, baicalin, isatis root extract, thyme extract, purple root extract, sage extract, peony root extract, mulberry leaf extract, hop extract and clove oil.
Experiments of the honeysuckle show that the honeysuckle has an inhibiting effect on typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus, pseudomonas aeruginosa, bordetella pertussis, vibrio cholerae, staphylococcus, streptococcus, pneumococcus, meningococcus and the like; inhibiting the synthesis of protein of drug-resistant bacteria, namely the honeysuckle extract has remarkable stimulation effect on the respiration of drug-resistant staphylococcus aureus plants, and is mainly used for treating medical and surgical inflammation caused by the drug-resistant bacteria, such as pulmonary tuberculosis complicated with respiratory tract infection, pneumonia, acute bacillary dysentery and diarrhea. It also serves to reduce the load-bearing rate of the throat; the baicalin has effects of inducing diuresis, relieving swelling, removing toxic substance, and expelling pus. Can expand blood vessel, prevent cardiovascular and cerebrovascular diseases, enhance myocardial contractility, and prevent formation of coronary artery and thrombosis. Helps insulin secretion, reduces blood sugar, enhances immunity, improves disease resistance of human body, and regulates endocrine function. Inhibiting melanin precipitation in vivo, resisting oxidation, resisting aging, and scavenging free radicals; radix Isatidis has effect on various bacteria. The water extract has inhibitory effect on Bacillus subtilis, staphylococcus aureus, sphaerococcus octopus, escherichia coli, salmonella typhi, bacillus paratyphi, dysentery (Shigella, freund) bacillus, and enteritis bacillus; the acetone extract also has similar effect and is effective on hemolytic streptococcus; the thyme has the antibacterial effect of resisting different pathogens such as staphylococcus aureus, bacillus subtilis, escherichia coli and the like, and also has a certain preservative effect; the radices violae can clear away heat and toxic materials and enhance the resistance of the stems, leaves and roots of the radices violae, contains the components of radices violae polysaccharide, radicalin and the like, and can enhance the resistance of a human body to diseases; the salvia has the effects and effects of sterilizing, promoting gastrointestinal peristalsis and the like, contains natural antiseptic components, and can play a role in inhibiting bacterial breeding and reproduction; the peony root has the effects of resisting bacteria and diminishing inflammation, contains a certain antibacterial component, can kill escherichia coli, typhoid bacillus and paratyphoid bacillus in vivo, and also has obvious inhibiting and killing effects on staphylococcus aureus, pneumococcus and the like; the mulberry leaves have the functions of antivirus, bacteriostasis and anti-inflammation; the hop contains lupulone, humulone, etc., and has effects of inhibiting Bacillus tuberculosis, staphylococcus aureus, bacillus subtilis, etc., reducing blood sugar, promoting digestion, tranquilizing, relieving pressure, and relieving joint pain. The oleum Caryophylli contains eugenol and tannin. Researches show that the clove oil has broad-spectrum antibacterial effect on staphylococcus aureus, escherichia coli, yeast, aspergillus niger and the like.
Example 1:
the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition comprises a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials in parts by weight:
16 parts of honeysuckle extract, 1.9 parts of baicalin, 12.8 parts of isatis root extract, 6.6 parts of thyme extract, 7.5 parts of violet root extract, 3 parts of sage extract, 2.7 parts of peony root extract, 4.6 parts of mulberry leaf extract, 2 parts of hop extract and 1.1 parts of clove oil.
The preparation method of the oral-nasal spray of the epidemic prevention antibactericide qingkailing composition in the embodiment 1 comprises the following steps:
s1, mixing a honeysuckle extract, an isatis root extract, a thyme extract, a radix rhois extract, a sage extract, a peony root extract, a mulberry leaf extract and a hop extract at normal temperature, homogenizing and stirring at the speed of 30 r/min;
s2, adding baicalin and clove oil into the mixed solution, and stirring at a low speed to be homogeneous, wherein the stirring speed is 20 r/min;
and S3, performing sampling inspection, and filling the qualified product into a spray bottle.
Example 2:
the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition comprises a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials in parts by weight:
18 parts of honeysuckle extract, 1.5 parts of baicalin, 10.6 parts of isatis root extract, 9.2 parts of thyme extract, 6.2 parts of radix violae extract, 4 parts of sage extract, 2.2 parts of peony root extract, 3.3 parts of mulberry leaf extract, 2.6 parts of hops extract and 0.9 part of clove oil.
The preparation method of the oral-nasal spray of the epidemic prevention and sterilization qingkailing composition in the embodiment 2 comprises the following steps:
s1, mixing a honeysuckle extract, an isatis root extract, a thyme extract, a radix rhois extract, a sage extract, a peony root extract, a mulberry leaf extract and a hop extract at normal temperature, homogenizing and stirring at the speed of 30 r/min;
s2, adding baicalin and clove oil into the mixed solution, and stirring at a low speed to be homogeneous, wherein the stirring speed is 20 r/min;
and S3, performing sampling inspection, and filling the qualified product into a spray bottle.
Example 3:
the oral and nasal spray of the epidemic prevention and sterilization qingkailing composition comprises a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials in parts by weight:
22 parts of honeysuckle extract, 1.2 parts of baicalin, 8.4 parts of isatis root extract, 12 parts of thyme extract, 5 parts of radix violae extract, 5 parts of sage extract, 1.4 parts of peony root extract, 2.4 parts of mulberry leaf extract, 3 parts of hops extract and 0.7 part of clove oil.
The preparation method of the oral-nasal spray of the epidemic prevention antibactericide qingkailing composition in the embodiment 3 comprises the following steps:
s1, mixing a honeysuckle extract, an isatis root extract, a thyme extract, a radix rhois extract, a sage extract, a peony root extract, a mulberry leaf extract and a hop extract at normal temperature, homogenizing and stirring at the speed of 30 r/min;
s2, adding baicalin and clove oil into the mixed solution, and stirring at a low speed to be homogeneous, wherein the stirring speed is 20 r/min;
and S3, performing sampling inspection, and filling the qualified product into a spray bottle.
Some tests were conducted on the oral-nasal spray of the anti-epidemic and bactericidal qingkailing composition prepared in examples 1-3.
Experimental example 1
Irritation test
Animal experiments were conducted to investigate the irritation of the oral nasal spray of qingkailing composition prepared in examples 1-3. 40 mice were divided into 4 groups randomly, and multiple administrations were administered continuously in the same site in the same single administration manner for 7 days with the same administration time and dosage. The skin irritation response scoring standard of the research technical guidance principle of chemical drug irritation, anaphylaxis and hemolysis is referred to for scoring, and then the average score is calculated, and the result is shown in table 1.
TABLE 1 mean values of skin irritation for oral nasal sprays of qingkailing composition
The experimental result shows that the qingkailing composition oral-nasal spray has certain stimulation effect on the skin of a laboratory mouse, but the irritation is not large and is within a reasonable range.
Experimental example 2
Candida albicans bacteriostasis experiment
The oral and nasal sprays of qingkailing compositions prepared in examples 1 to 3 were tested for their bacteriostatic effect (bacteriostatic rate%) on candida albicans diluted with diluent (PBS) at different time nodes, according to the test method: item 2.1.11.3.2, 2002 edition, experimental temperature 20-22 ℃. The results are shown in Table 2.
TABLE 2 oral nasal spray of qingkailing composition for inhibiting candida albicans
Experimental results show that the qingkailing composition oral-nasal spray has obvious bacteriostatic and bactericidal effects on candida albicans.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition is characterized by comprising a spray bottle and the qingkailing composition, wherein the qingkailing composition is prepared from the following raw materials:
honeysuckle extract, baicalin, isatis root extract, thyme extract, violet root extract, sage extract, peony root extract, mulberry leaf extract, hop extract and clove oil.
2. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition as claimed in claim 1, which is characterized in that the qingkailing composition is prepared from the following raw materials in parts by weight:
14-22 parts of honeysuckle extract, 1.2-1.9 parts of baicalin, 8-14 parts of isatis root extract, 6-12 parts of thyme extract, 4-8 parts of violet root extract, 3-5 parts of sage extract, 1-3 parts of peony root extract, 2-5 parts of mulberry leaf extract, 2-3 parts of hop extract and 0.6-1.2 parts of clove oil.
3. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition as claimed in claim 2, which is characterized in that the qingkailing composition is prepared from the following raw materials in parts by weight:
16 parts of honeysuckle extract, 1.9 parts of baicalin, 12.8 parts of isatis root extract, 6.6 parts of thyme extract, 7.5 parts of violet root extract, 3 parts of sage extract, 2.7 parts of peony root extract, 4.6 parts of mulberry leaf extract, 2 parts of hop extract and 1.1 parts of clove oil.
4. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition as claimed in claim 2, which is characterized in that the qingkailing composition is prepared from the following raw materials in parts by weight:
18 parts of honeysuckle extract, 1.5 parts of baicalin, 10.6 parts of isatis root extract, 9.2 parts of thyme extract, 6.2 parts of radix violae extract, 4 parts of sage extract, 2.2 parts of peony root extract, 3.3 parts of mulberry leaf extract, 2.6 parts of hops extract and 0.9 part of clove oil.
5. The oral and nasal spray of the epidemic prevention and sterilization qingkailing composition as claimed in claim 2, which is characterized in that the qingkailing composition is prepared from the following raw materials in parts by weight:
22 parts of honeysuckle extract, 1.2 parts of baicalin, 8.4 parts of isatis root extract, 12 parts of thyme extract, 5 parts of violet root extract, 5 parts of sage extract, 1.4 parts of peony root extract, 2.4 parts of mulberry leaf extract, 3 parts of hop extract and 0.7 part of clove oil.
6. The oral-nasal spray of the epidemic prevention antibactericide qingkailing composition as claimed in claim 1, wherein the preparation method of the honeysuckle extract comprises the following steps:
(1) Pulverizing fresh flos Lonicerae with pulverizer to obtain flos Lonicerae particles with particle size of 20-40 mesh;
(2) Adding a solvent, and adding ethanol into the arrowhead particles to obtain a mixed solution, wherein the mass ratio of the honeysuckle particles to the ethanol is 1:8-10 ℃, the temperature is 18-25 ℃, and the soaking time is 1.5-2h;
(3) Performing enzymolysis extraction, namely adding cellulase into the mixed solution, wherein the weight ratio of the cellulase to the raw materials is 0.5%, the pH value is 5.0, the temperature is kept at 53 ℃, and the enzymolysis time is 3.0h;
(4) Performing centrifugal separation, namely performing centrifugal separation on the enzymolysis liquid obtained in the step (3), and centrifuging for 10-15min in a centrifugal machine with the rotating speed of 2000-2500rpm to obtain clear liquid and honeysuckle residues;
(5) Heating to inactivate enzyme, heating the clear liquid obtained in step (4) to inactivate enzyme, and separating solvent to obtain flos Lonicerae extractive solution at 95-100 deg.C for 10-15min.
7. The oral nasal spray of an anti-epidemic and antibacterial qingkailing composition according to claim 1, wherein the percentage of the fog drops with the particle size distribution of 2 μm to 5 μm in the total volume of the fog drops is more than 75%.
8. The oral-nasal spray of an anti-epidemic and antibacterial qingkailing composition according to claim 1, is used for disinfection and bacteriostasis at oral and nasal cavities and prevention of invasion of bacteria or viruses.
9. The method for preparing the oral-nasal spray of the epidemic prevention and sterilization qingkailing composition according to any one of claims 1 to 8, which is characterized by comprising the following steps:
s1, mixing a honeysuckle extract, an isatis root extract, a thyme extract, a radix rhois extract, a sage extract, a peony root extract, a mulberry leaf extract and a hop extract at normal temperature, and homogenizing;
s2, adding baicalin and clove oil into the mixed solution, and slowly stirring until the mixture is homogeneous;
s3, performing sampling inspection, and filling the qualified product into a spray bottle.
10. The method for preparing the oral-nasal spray of the epidemic prevention and disinfection qingkailing composition according to claim 9, wherein the stirring speed in S1 and S2 is 20-30r/min.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583179A (en) * | 2003-08-20 | 2005-02-23 | 天津药物研究院 | Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583179A (en) * | 2003-08-20 | 2005-02-23 | 天津药物研究院 | Pure Chinese medicinal anti-virus and bactericidal spraying agent and its preparation |
Non-Patent Citations (2)
| Title |
|---|
| 刘良丽: "清开灵粉针剂雾化吸入治疗慢性支气管炎急性发作临床观察", 湖北中医杂志, no. 06, pages 14 - 15 * |
| 李湘蕾: "两种药物超声雾化吸入对小儿上感的疗效比较", 中华全科医学, vol. 8, no. 02, pages 253 - 254 * |
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