CN1527689A - 用于治疗干眼的置入物 - Google Patents
用于治疗干眼的置入物 Download PDFInfo
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- CN1527689A CN1527689A CNA028139941A CN02813994A CN1527689A CN 1527689 A CN1527689 A CN 1527689A CN A028139941 A CNA028139941 A CN A028139941A CN 02813994 A CN02813994 A CN 02813994A CN 1527689 A CN1527689 A CN 1527689A
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (17)
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DE10133870.8 | 2001-07-12 | ||
DE10133870A DE10133870A1 (de) | 2001-07-12 | 2001-07-12 | Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge |
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CN1527689A true CN1527689A (zh) | 2004-09-08 |
CN100345528C CN100345528C (zh) | 2007-10-31 |
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CNB028139941A Expired - Lifetime CN100345528C (zh) | 2001-07-12 | 2002-07-12 | 用于治疗干眼的置入物 |
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US (2) | US20040176749A1 (zh) |
EP (1) | EP1404264B1 (zh) |
JP (1) | JP2004538056A (zh) |
CN (1) | CN100345528C (zh) |
CA (1) | CA2453384A1 (zh) |
DE (1) | DE10133870A1 (zh) |
HK (1) | HK1068778A1 (zh) |
WO (1) | WO2003005941A2 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007051345A1 (fr) * | 2005-10-31 | 2007-05-10 | Life Spring Biotech Co., Ltd. | Bande de cerclage scleral et procede pour la fabriquer |
CN101547666B (zh) * | 2006-08-21 | 2012-06-20 | 眼泪科学公司 | 用于治疗腺体功能障碍的器械 |
CN107224348A (zh) * | 2017-06-01 | 2017-10-03 | 复旦大学附属眼耳鼻喉科医院 | 一种眼表缓释给药装置及其制造方法 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1658109B1 (en) | 2003-08-26 | 2014-01-22 | Vista Scientific LLC | Ocular drug delivery device |
US20050275799A1 (en) * | 2004-03-10 | 2005-12-15 | Marmo J C | Contact lenses, package systems, and method for promoting a healthy epithelium of an eye |
EP1765454B1 (en) * | 2004-07-02 | 2016-04-13 | Mati Therapeutics Inc. | Treatment medium delivery device for the eye |
US20080038317A1 (en) * | 2004-09-10 | 2008-02-14 | Chin-Ming Chang | Therapeutic Lacrimal Canalicular Inserts And Related Methods |
EP1853207A1 (en) * | 2005-01-20 | 2007-11-14 | I-Shine Danmark ApS | Apparatus for dispension of liquid |
US20080132451A1 (en) * | 2006-12-01 | 2008-06-05 | Alcon Manufacturing Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
UY30883A1 (es) | 2007-01-31 | 2008-05-31 | Alcon Res | Tapones punctales y metodos de liberacion de agentes terapeuticos |
FR2917416B1 (fr) * | 2007-06-13 | 2012-08-10 | Essilor Int | Procede de traitement de la surface d'un substrat a base de polymere soufre destine a etre recouvert par un revetement |
EP3415172A1 (en) | 2009-06-16 | 2018-12-19 | TheraDep Technologies, Inc. | Wound healing device |
MX2013001116A (es) * | 2010-07-29 | 2013-06-05 | Santen Pharma Co Ltd | Cuerpo para soporte de farmaco, y metodo para producir el mismo. |
CN103168099B (zh) * | 2010-08-25 | 2016-08-03 | 独立行政法人农业生物资源研究所 | 水凝胶干燥体、玻璃质凝胶膜干燥体及它们的制造方法 |
JP5933223B2 (ja) * | 2010-11-12 | 2016-06-08 | 国立研究開発法人農業生物資源研究所 | 細胞培養チャンバーとその製造方法、および、この細胞培養チャンバーを利用した組織モデルとその作製方法 |
ES2764117T3 (es) | 2010-12-13 | 2020-06-02 | Theradep Tech Inc | Dispositivos médicos implantables |
WO2013040238A2 (en) | 2011-09-13 | 2013-03-21 | Vista Scientific Llc | Sustained release ocular drug delivery devices and methods of manufacture |
US10010502B2 (en) | 2015-05-19 | 2018-07-03 | Amorphex Therapeutics Llc | Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation |
WO2017136334A1 (en) | 2016-02-01 | 2017-08-10 | Theradep Technologies Inc. | Systems and methods for delivering therapeutic agents |
US11690998B2 (en) | 2017-10-31 | 2023-07-04 | Theradep Technologies, Inc. | Methods of treating bacterial infections |
US11147737B2 (en) | 2018-02-26 | 2021-10-19 | Olympic Ophthalmics, Inc. | Handheld device with motorized member for treatment of disorders |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3986510A (en) * | 1971-09-09 | 1976-10-19 | Alza Corporation | Bioerodible ocular device |
CA1311686C (en) * | 1986-06-25 | 1992-12-22 | John Weldon Shell | Controlled release bioerodible drug delivery system |
US5989579A (en) * | 1986-10-02 | 1999-11-23 | Escalon Medical Corp. | Ocular insert with anchoring protrusions |
US5137728A (en) * | 1988-03-01 | 1992-08-11 | Bausch & Lomb Incorporated | Ophthalmic article |
US4923700A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Artificial tear suspension |
US5036046A (en) * | 1988-10-12 | 1991-07-30 | Eye Research Institute Of Retina Foundation, Inc. | Method for enhancing healing of corneal endothelial wounds |
US5660851A (en) * | 1989-12-26 | 1997-08-26 | Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem | Ocular inserts |
KR960002739B1 (ko) * | 1990-08-31 | 1996-02-26 | 데루오 니시다 | 각막 장해 치료제 |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5290572A (en) * | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
WO1994005257A1 (en) * | 1992-09-08 | 1994-03-17 | Allergan, Inc. | Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle |
US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5518732A (en) * | 1995-02-14 | 1996-05-21 | Chiron Vision, Inc. | Bio-erodible ophthalmic shield |
AR004214A1 (es) * | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
JP3093661B2 (ja) * | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
US5904144A (en) * | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
US6299895B1 (en) * | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
US5797898A (en) * | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US7070590B1 (en) * | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
JPH10158188A (ja) * | 1996-11-29 | 1998-06-16 | Senju Pharmaceut Co Ltd | 角膜治療用組成物 |
JP2003502282A (ja) * | 1999-04-08 | 2003-01-21 | ザ ゼネラル ホスピタル コーポレーション | ヒト転移性細胞の作用因子源から離れた意図された移動 |
ATE499988T1 (de) * | 2000-03-02 | 2011-03-15 | Microchips Inc | Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien |
DE60219607T2 (de) * | 2001-01-09 | 2007-12-27 | Microchips, Inc., Bedford | Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation |
-
2001
- 2001-07-12 DE DE10133870A patent/DE10133870A1/de not_active Withdrawn
-
2002
- 2002-07-12 CN CNB028139941A patent/CN100345528C/zh not_active Expired - Lifetime
- 2002-07-12 WO PCT/EP2002/007805 patent/WO2003005941A2/de active Application Filing
- 2002-07-12 EP EP02764682.7A patent/EP1404264B1/de not_active Expired - Lifetime
- 2002-07-12 JP JP2003511751A patent/JP2004538056A/ja active Pending
- 2002-07-12 CA CA002453384A patent/CA2453384A1/en not_active Abandoned
- 2002-07-12 US US10/483,047 patent/US20040176749A1/en not_active Abandoned
-
2005
- 2005-02-22 HK HK05101463A patent/HK1068778A1/xx not_active IP Right Cessation
-
2008
- 2008-10-14 US US12/285,707 patent/US20090041828A1/en not_active Abandoned
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007051345A1 (fr) * | 2005-10-31 | 2007-05-10 | Life Spring Biotech Co., Ltd. | Bande de cerclage scleral et procede pour la fabriquer |
CN101304708B (zh) * | 2005-10-31 | 2011-06-22 | 生立生物科技股份有限公司 | 巩膜环扣带及其制法 |
CN101547666B (zh) * | 2006-08-21 | 2012-06-20 | 眼泪科学公司 | 用于治疗腺体功能障碍的器械 |
CN107224348A (zh) * | 2017-06-01 | 2017-10-03 | 复旦大学附属眼耳鼻喉科医院 | 一种眼表缓释给药装置及其制造方法 |
Also Published As
Publication number | Publication date |
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CA2453384A1 (en) | 2003-01-23 |
US20090041828A1 (en) | 2009-02-12 |
EP1404264A2 (de) | 2004-04-07 |
DE10133870A1 (de) | 2003-02-06 |
WO2003005941A2 (de) | 2003-01-23 |
US20040176749A1 (en) | 2004-09-09 |
HK1068778A1 (en) | 2005-05-06 |
CN100345528C (zh) | 2007-10-31 |
EP1404264B1 (de) | 2019-01-23 |
JP2004538056A (ja) | 2004-12-24 |
WO2003005941A3 (de) | 2003-09-18 |
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