CN1420843A - 原硅酸的制备方法,获得的原硅酸,和它的用途 - Google Patents
原硅酸的制备方法,获得的原硅酸,和它的用途 Download PDFInfo
- Publication number
- CN1420843A CN1420843A CN00818256A CN00818256A CN1420843A CN 1420843 A CN1420843 A CN 1420843A CN 00818256 A CN00818256 A CN 00818256A CN 00818256 A CN00818256 A CN 00818256A CN 1420843 A CN1420843 A CN 1420843A
- Authority
- CN
- China
- Prior art keywords
- silicon
- orthosilicic acid
- acid
- carrier
- orthosilicic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 238000000034 method Methods 0.000 title claims abstract description 20
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 62
- 229910052710 silicon Inorganic materials 0.000 claims abstract description 61
- 239000010703 silicon Substances 0.000 claims abstract description 61
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 235000013305 food Nutrition 0.000 claims abstract description 13
- 150000003377 silicon compounds Chemical class 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 10
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 8
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 8
- 239000002537 cosmetic Substances 0.000 claims abstract description 7
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000006052 feed supplement Substances 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 11
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims description 8
- 238000006460 hydrolysis reaction Methods 0.000 claims description 7
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 230000007062 hydrolysis Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000000178 monomer Substances 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 229960004559 theobromine Drugs 0.000 claims description 4
- 231100000956 nontoxicity Toxicity 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 231100000987 absorbed dose Toxicity 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 20
- -1 polyoxyethylene Polymers 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000000377 silicon dioxide Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 9
- 239000000084 colloidal system Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 235000012239 silicon dioxide Nutrition 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 6
- 230000037213 diet Effects 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 229960001866 silicon dioxide Drugs 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- 235000015872 dietary supplement Nutrition 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 4
- 239000008108 microcrystalline cellulose Substances 0.000 description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 241001071864 Lethrinus laticaudis Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 235000013351 cheese Nutrition 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- GKLSYIMLZDYQBJ-UHFFFAOYSA-N 2''-O-alpha-rhamnosyl-6-C-(6-deoxy-xylo-hexos-4-ulosyl)-luteolin Natural products OC1C(O)C(O)C(C)OC1OC1C(C=2C(=C3C(=O)C=C(OC3=CC=2O)C=2C=C(O)C(O)=CC=2)O)OC(C)C(=O)C1O GKLSYIMLZDYQBJ-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 241000206761 Bacillariophyta Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- GKLSYIMLZDYQBJ-HQBRDMKGSA-N Maysin Natural products O([C@H]1[C@@H](O)C(=O)[C@@H](C)O[C@@H]1c1c(O)c2C(=O)C=C(c3cc(O)c(O)cc3)Oc2cc1O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](C)O1 GKLSYIMLZDYQBJ-HQBRDMKGSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 235000012204 lemonade/lime carbonate Nutrition 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- GKLSYIMLZDYQBJ-CGOKOBCESA-N maysin Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](C)O[C@@H]1O[C@@H]1[C@@H](C=2C(=C3C(=O)C=C(OC3=CC=2O)C=2C=C(O)C(O)=CC=2)O)O[C@@H](C)C(=O)[C@H]1O GKLSYIMLZDYQBJ-CGOKOBCESA-N 0.000 description 2
- PDXPLYCPNXZSAL-UHFFFAOYSA-N maysine Natural products CN1C(=O)C=CC2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 PDXPLYCPNXZSAL-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 235000019353 potassium silicate Nutrition 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- LFQCEHFDDXELDD-UHFFFAOYSA-N tetramethyl orthosilicate Chemical compound CO[Si](OC)(OC)OC LFQCEHFDDXELDD-UHFFFAOYSA-N 0.000 description 2
- POWFTOSLLWLEBN-UHFFFAOYSA-N tetrasodium;silicate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-][Si]([O-])([O-])[O-] POWFTOSLLWLEBN-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 244000085625 Equisetum Species 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001343 alkyl silanes Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000007091 anti poisonous effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000018678 bone mineralization Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000020940 control diet Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000021321 essential mineral Nutrition 0.000 description 1
- CWAFVXWRGIEBPL-UHFFFAOYSA-N ethoxysilane Chemical compound CCO[SiH3] CWAFVXWRGIEBPL-UHFFFAOYSA-N 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 238000000673 graphite furnace atomic absorption spectrometry Methods 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-N hexanedioic acid Natural products OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 1
- PMYUVOOOQDGQNW-UHFFFAOYSA-N hexasodium;trioxido(trioxidosilyloxy)silane Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-][Si]([O-])([O-])O[Si]([O-])([O-])[O-] PMYUVOOOQDGQNW-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 229940049918 linoleate Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003415 peat Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000020245 plant milk Nutrition 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicon Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明涉及一种原硅酸的制备方法，其中在非毒性溶剂试剂存在下，在原硅酸形成下，在酸溶液中水解可酸水解硅化合物，其中优选将形成的原硅酸与非毒性微粒载体接触，和涉及硅制剂在动物饲料、食品、食品或饲料补充物、和药物或化妆品制剂生产中的用途。
Description
本发明涉及原硅酸的制备方法，涉及可通过此方法获得的原硅酸和涉及它作为硅氧烷制剂在动物饲料、食品、食品或饲料补充物的生产中、和用于药物或化妆品制剂生产中的用途。已经认为硅(Si)是硅藻类，硅蓄积植物和高级动物的必要痕量元素。硅在脊椎动物中的最好的已经证明了的功能是它在骨钙化中的调节作用和它与结缔组织中细胞外基质的几种组分的化学缔合(Carlisle E.(1989)，硅，在：Handbook ofNutritionally Essential Mineral Elements ed.B.L.O’Dell andR.A.Sunde，Marcel Dekker Inc.，纽约，603-618页)。此基质主要由嵌入水合多糖凝胶的纤维蛋白如胶原蛋白组成。认为结合到此基质组分上的硅对于结构完整性，结缔组织的发育和调节功能是重要的。硅的胃-肠吸收仅在饮食硅-化合物水解成原硅酸之后才是可能的。硅化合物在饮食中的溶解性较低，因此这些化合物的生物可利用性有限。未在生物系统中发现包括硅-C键的有机化合物，并发现几类合成产物具有不可接受的毒性。天然溶解性硅化合物，也称为单体硅酸的原硅酸在淡水和海水中都存在，但浓度非常低(＜1mmoll-1[Sullivan C.(1986)由硅藻类的硅化，在：Silicon Biochemistry，CIBA Foundation Symposiuml21，John Wileyand Sons，纽约，24-39页])。在含水介质中的更高浓度引发聚合反应变成生物不可利用的胶体并最终成为凝胶。稳定化原硅酸制剂的制备方法公开于US5,922,360。
本发明的目的是提供一种从相对便宜和市场可得的起始材料开始，同时基本避免形成的原硅酸聚合的原硅酸制备方法。
此目的可采用根据本发明的原硅酸制备方法获得，其中非毒性溶剂试剂存在下，在原硅酸的形成下，将可酸水解的硅化合物在酸溶液，如酸水溶液中水解。由于使用酸溶液和由于非毒性溶剂试剂的存在基本抑制了上述聚合反应并且形成的原硅酸是足够稳定的。
起始材料，它是可酸水解硅化合物，可选自硅酸盐，如单体硅酸盐，如硅卤化物、原硅酸甲酯、原硅酸钠或镁，或选自水合硅酸盐如结晶硅酸钠。
根据另一个实施方案，可酸水解硅化合物具有如下通式：
其中R1，R2，R3和R4独立地选自H、C1-C12烷基、任意地被羟基取代的C1-C12烷氧基，条件是R1，R2，R4和R4不同时为H。优选，R1，R2，R3和R4选自H、C1-C4烷基、任意地被羟基取代的C1-C4烷氧基。注意优选选择R1，R2，R3和R4使得从可水解硅化合物分裂出的化合物可使用传统技术如蒸发和蒸馏除去，最优选的是非毒性的(大鼠中的口服LD50高于1g/kg体重)。最优选的硅化合物是四乙氧基硅烷醇。
R的其它优选例子是C2H5、CH3CO、HCO、C3H7、C4H9和CH3CH(OH)CHCO。溶液可包括1-80％，优选10-70％，更优选40-60％溶剂试剂。
用于酸溶液以稳定形成的原硅酸的非毒性溶剂试剂可选自二醇、甘油、(聚)亚烷基二醇、DMSO和聚山梨酸酯80。(聚)亚烷基二醇可以是聚丙二醇或聚乙二醇。亚烷基二醇可以是乙二醇或丙二醇。对于所有非毒性溶剂试剂的通常类性能是在水中的高溶解性(大于30％)，高于130℃的沸点，在-10℃到40℃下为液态和在一般0-4的酸pH下稳定。
由非毒性溶剂试剂稳定的形成的原硅酸，可以通过将原硅酸与非毒性微粒载体接触而进一步稳定。
令人惊奇地，体验到吸附原硅酸的此非毒性微粒载体具有生物可利用性，它可以与稳定化制剂相比甚至有改进，如在US5,922,360中公开的那样。生物可利用性是关键的因素，这是由于近来显示在比较人体补充物研究中，固体硅补充物如胶体二氧化硅和植物性硅酸盐不是生物可利用的，而稳定的原硅酸在HCl-胆碱基质中的溶液具有高的生物可利用性[Calomme M.，Cos P.，Vingerhoets R.，Van Hoorebeke C.，VandenBerghe D.(1998)硅补充物在健康对象中的比较生物可利用性研究，Journal of Parenteral and Enteral Nutrition，22，S12，(文摘#47)Van Dyck K.，Van Cauwenbergh R.，Robberecht H.，DeelstraH.(1999)，来自食品和食品补充物的硅的生物可利用性，FreseniusJournal of Analytical Chemistry，363，541-544]。因此，本发明也提供硅制剂，包括吸附在微粒载体上的原硅酸，通过包括如下步骤的方法获得：
i)提供溶液，包括采用该酸溶剂试剂稳定化的原硅酸；和
ii)将包括原硅酸的溶液与微粒载体接触。
为避免达到原硅酸聚合的另外程度，优选原位形成原硅酸。当在与原硅酸接触之后将载体挤出时，硅制剂的剂型的处理和形成得到进一步改进。
熟练技术人员会认识到依赖于硅制剂的所需用途，根据本发明的硅制剂可包含在宽硅含量范围的原硅酸。一般情况下，硅制剂的硅含量在0.01-50wt％，优选0.01-10wt％，更优选0.1-10wt％，最优选0.1-5wt％的范围内。因此，硅制剂可用于适于最希望的食品、饲料、药物和化妆品用途的剂量方案。在此方面，注意到药物和化妆品制剂可对指甲、头发、皮肤、牙齿、胶原蛋白、结缔组织、骨头、促进细胞增生、刺激免疫系统抗感染和毒物和抑制变性(老化)过程有积极的效果。此外，注意到溶剂试剂和载体应当是非毒性的，它意味着在人体、动物和植物中不引发毒副反应效果。
使用根据本发明的硅制剂的试验已经显示，硅制剂具有所需的高生物可利用性，表达为由有机体如人体的总的硅吸收。与前述胶体和植物性二氧化硅制剂相比，在0-8小时内的相对生物可利用性得到更大改进。换言之，在8小时内的总硅吸收量大于250(μg)硅h/l，优选大于500(μg)硅h/l，更优选大于600(μg)硅h/l，如250-700(μg)硅h/l，优选300-700(μg)硅h/l。
吸附在载体上的根据本发明的硅制剂可以以这样的形式使用或与任何可接受的载体材料、赋形剂或稀释剂结合使用。
根据本发明的硅制剂可以口服给予或以任何其它合适的方式给予。口服给药是优选的并且硅制剂的形式可为片剂、含水分散体、可分散粉末或颗粒、乳液、硬或软胶囊、糖浆、酏剂或凝胶。剂型可以使用在制造这些药物或化妆品组合物领域已知的任何方法制备，并可包括添加剂如甜料、调味剂、着色剂、防腐剂等。载体材料和赋形剂可包括碳酸钙、碳酸钠、乳糖、磷酸钙或磷酸钠、成颗粒剂和崩解剂、粘合剂等。硅制剂可包括在与任何惰性固体稀释剂或载体材料混合的明胶胶囊中，或具有软明胶胶囊的形式，其中将该成分与水或油介质混合。含水分散体可包括与悬浮剂、分散剂或润湿剂结合的硅制剂。油分散体可包括悬浮剂如植物油。可以按照在US5,922,360中的教导制备凝胶制剂。
目前可以制备载体结合的原硅酸与如下其它组分的干燥混合物：如痕量元素、维生素、氨基酸、糖、植物提取物、和用于生产食品和食品补充物的其它成分。作为解释，考虑到在载体结合的原硅酸中原硅酸保持它的单体形式，因此不同于原硅酸的生物不可利用的聚合形式物如在胶体或固体硅酸和硅酸盐中。
例如在酸溶剂试剂存在下并且在原位，通过如下方式制备原硅酸：(a)单体硅化合物如硅卤化物或原硅酸甲酯的水解[Iler R.(1979)单硅酸，在：硅化学，John Wiley and Sons，纽约，178-180页]，(b)将单体硅酸盐如原硅酸钠或镁或水合结晶硅酸钠与稀酸反应[Iler 1979]，(c)水解有机烷基硅烷醇化合物。注意到在形成的原硅酸之后，其它水解反应化合物应当是非毒性的并且如需要应当从反应混合物中除去。优选，烷基硅烷醇化合物是乙氧基硅烷醇化合物，并且形成的乙醇可以不费力地分离。新鲜制备的原硅酸结合到载体上或是载体的结合物上。第二种方法是首先将有机硅化合物结合到载体上，其后例如在低于4，如0.2-2.5，更优选0.8-1.0的pH下，将有机硅化合物水解成原硅酸。
固体载体或固体载体的结合物可选自：
i)天然和半合成纤维，
ii)植物代谢物如polyfenol、木脂素、黄酮类化合物，
iii)脂肪酸及其酯如硬脂酸酯、棕榈酸酯、亚油酸酯、油酸酯、己二酸酯、辛酸酯、癸酸酯、椰子酯(cocoates)，
iv)磷脂及其衍生物，
v)多醇如肌醇、海藻糖，
vi)氢化和硫酸化化合物，
vii)盐如氯化物、硫酸盐、硝酸盐等，
viii)果胶和藻酸盐，
ix)糖或糖醇及其衍生物如乳糖、蔗糖、甘露糖醇、山梨糖醇、山梨醇酯，
x)多糖或低聚糖硅acharides及其衍生物如葡聚糖、果聚糖、菊粉、低聚果糖，
xi)明胶或其衍生物如明胶水解产物，
xii)纤维素或其衍生物如微晶纤维素、羟丙基纤维素、羟丙基甲基纤维素、羧甲基纤维素、纤维素树胶，
xiii)肽和多肽如如胶原蛋白、大豆蛋白、玉米面球蛋白及其衍生物，
xiv)葡聚糖及其衍生物如蛋白聚糖、葡糖胺聚糖、玻璃糖醛酸、硫酸软骨素、肝素、硫酸乙酰肝素、硫酸角质素、硫酸皮肤素。
xv)淀粉及其衍生物，
xvi)卵磷脂及其衍生物，如
xvii)食品生产的副产物，如来自乳酪、啤酒和玉米的发酵副产物，和乳酪乳清，
xviii)食品副产物如干燥动物食品、用于植物的基质如用于植物生产的天然泥炭、干燥植物提取物是干燥植物匀浆和化妆品粉末如滑石。
实例例A
按如下方式制备原硅酸。将两升冷硅酸钠的新鲜溶液(14％NaOH中的27％SiO2)与2-4升甘油(前分析，100％)混合，直到获得均匀的溶液。为降低pH，加入一升冷，浓盐酸和将混合物在0-10℃的温度下剧烈搅拌。在连续混合期间，加入碳酸钙的固体或悬浮液直到获得1-3的pH。在混合期间，会形成CO2气体。
将半升新制备的浓原硅酸结合物与如下物质混合：0.5kg明胶，或0.5kg乳酪乳清，或200g纤维素，或1kg半乳糖，或1kg蔗糖。混合所得的糊剂直到获得均匀的糊剂。将糊剂在真空中干燥。最终产物包含最小0.1％元素硅和优选1-5％元素硅。
在2个月期间0.5g的每日摄入量导致在四个不同的人中指甲和头发质量的改进。此改进等同于使用US5,922,360中制剂观察到的情况。
实施例B
将载体(65％)微晶纤维素与35％浓原硅酸和甘油(参见实施例A)的结合物混合。在连续混合期间加入软化水以获得合适量的颗粒化材料。采用篮式挤出机(Caleva型10，Sturminster Newton，Great Britain)在750rpm下挤出塑性本体。将挤出条团成球状(Caleve型120成球机)。将获得的粒料干燥到最终水含量小于5％。典型的粒料尺寸为800-1200μm。在尺寸00的硬明胶胶囊中封囊粒料。每个胶囊包含0.54g粒料，等于5mg以载体结合原硅酸形式的元素硅。微晶纤维素的负载能力可以增加到45％原硅酸。
实施例C
将载体，大豆蛋白质和玉米面球蛋白质的混合物(1∶1)(70％)与30％原硅酸与甘油的结合物(参见实施例A)混合。在连续混合期间加入软化水以获得均匀的塑性本体。将混合物通过冻干法干燥。在成颗粒之后，将蛋白质结合的原硅酸直接封囊或用作动物饲料、食品、食品补充物、化妆品或药物制剂的原材料。
实施例D
将载体(65％)，微晶纤维素和果聚糖的混合物(3∶1)与35％浓原硅酸与甘油的结合物(参见实施例A)混合。在连续混合期间加入软化水以获得合适量的颗粒化材料。采用篮式挤出机(Caleva型10，SturminsterNewton，Great Britain)在750rpm下挤出塑性本体。将挤出条团成球状(Caleve型120成球机)。将获得的粒料干燥到最终水含量小于5％。典型的粒料尺寸为800-1400μm。将粒料压成片剂或用作动物饲料、食品、食品补充物、化妆品或药物制剂的原材料。
实施例E
将100ml冰冷四乙氧基硅烷醇缓慢滴加到1升50％冰冷甘油水溶液中，pH1.0。在0℃下8h之后，硅烷醇化合物完全水解。通过在真空下的快速蒸发除去乙醇。
将剩余的OSA溶液与作为糊剂的2-3kg乳糖混合和进一步在真空下干燥。最终产物包含最小0.1％硅和优选0.3-2％硅。
实施例A-E制剂的溶解测定显示原硅酸在30分钟之内释入到溶解介质中。这可通过在固定时间点，采用Zeeman校正的电热原子吸收光谱(Perkin Elmer)仪，测量溶解介质的硅含量而说明。原硅酸在溶解期间释放的事实清楚地说明了原硅酸对载体的结合并不导致原硅酸的聚合，而保留为可分离的形式。在生产日期3，6和12个月之后，重复溶解测定，没有差异的结果显示载体结合的原硅酸在较长时间内是化学稳定的。
实施例F
在被告知，写下同意书之后，征集三个健康对象(2个女性，1个男性，年龄22-34岁)。在开始研究之前3个月之内没有人摄入硅补充物。每个禁食对象接受如下的交叉方案口服硅：在每次补充物或安慰剂之间1周清除时间内接受形式为稳定化原硅酸的10mg硅(原硅酸，0.5ml包含20g硅/l的BioSil，如在US5,922,360中那样)，形式为载体结合的原硅酸的10mg硅(实施例D的胶囊制剂)，形式为胶体二氧化硅的20mg硅(聚合的原硅酸)，形式为植物性二氧化硅的20mg硅(硅-蓄积植物田野木贼属的标准化干燥提取物)或安慰剂(10ml矿泉水)。在补充之前和在补充后1，2，4，6和8小时，采集血样置于无硅的聚丙烯管中。在实验期间在补充2和6小时之后，消耗相同的膳食。在一个批次中采用AAS测量每个对象的血清和尿中的硅浓度。装配有HGA-600石墨炉的Zeeman/3030原子吸收光谱仪与AS-60自动采样器(Perkin-Elmer Corp.Norwalk CT)结合使用。使用线性梯形原则作为总硅吸收的目标参数，计算在时间浓度曲线(A.U.C.)下的面积。在补充液体原硅酸和载体结合原硅酸之后(图1原硅酸＝OSA)，血清硅浓度都从基线值显著增加，但在补充聚合原硅酸形式物如胶体二氧化硅或植物性二氧化硅之后，并不增加。相比于液体原硅酸，载体结合原硅酸的动力学吸收图指示较缓慢的释放作用。对于载体结合的原硅酸和液体原硅酸来说，总体生物可利用性相似，但原硅酸聚合形式物并不是生物可利用的，这是由于与安慰剂相比，这些产品看不出显著的差异(图2原硅酸＝OSA)。在载体结合的原硅酸生产日期一年之后，重复生物可利用性试验，结果没有显著的差异，说明载体结合的原硅酸在较长时间内是化学稳定的，没有显著的生物可利用性损失。图3说明采用如下形式10mg硅补充的志愿者(n＝3)血清中的动力学分布：(a)OSA液体，(b)新鲜制备的载体结合OSA，和(c)1年期的载体结合OSA。计算为时间曲线(A.U.C.)下的面积的相对生物利用性在不同硅形式物之间没有显著差异(平均值±SD)：分别是：安慰剂为132±28μg/L，OSA液体为795±231μg/L，新鲜制备的载体结合OSA为869±448μg/L，和对于1年期载体结合OSA为622±251μg/L。
实施例G
将用于母猪的饲料粒料(‘载体’)与浓原硅酸和甘油的结合物(参见实施例A)混合，直到获得形式为载体结合OSA的浓度为15mg硅/kg饲料。在受胎之前1周直到断奶，每天喂给母猪4kg此‘载体结合OSA’饲料。对照组母猪接受正常的饲料，除了没有载体结合OSA以外其余组成相同。从4周龄的小猪(断奶)抽取血液，并采用石墨炉原子吸收光谱测量血清中硅浓度。喂养‘载体结合OSA’饮食的小猪的平均血清硅浓度比对照组高150％(表1)，它清楚地说明(a)载体结合的OSA具有高的生物可利用性，(b)从载体结合OSA吸收的硅在泌乳母猪和后代之间通过胎盘或奶或两者的结合传递。
表1：喂给母猪OSA结合的饮食对后代血清硅浓度的影响
| 母猪的饮食组 | 后代(小猪)血清中硅浓度平均值±SE(ppb) |
| 规则对照饮食 | 109±8 |
| OSA结合的饮食 | 277±20 |
图1在分别补充以下物质之后健康对象中血清中硅浓度从基线值的增加：形式为载体结合OSA的10mg硅，形式为液体OSA的10mg硅，形式为胶体二氧化硅的20mg硅，形式为植物性二氧化硅的20mg硅。
图1
血清Si浓度
图2在分别补充以下物质之后0-8小时健康对象中测量的血清中硅的总吸收量：形式为载体结合OSA的10mg硅，形式为液体OSA的10mg硅，形式为胶体二氧化硅的20mg硅，形式为植物性二氧化硅的20mg硅。
图2
图3储藏一年期限载体结合OSA对健康对象中血清硅浓度增加的效果。
图3
Claims (15)
1.一种原硅酸的制备方法，其中在非毒性溶剂试剂存在下，在原硅酸的形成下，将可酸水解的硅化合物在酸溶液中水解。
2.权利要求1的方法，其中可酸水解硅化合物是硅酸盐，如单体硅酸盐或水合硅酸盐。
3.权利要求1的方法，其中可酸水解硅化合物具有如下通式：
其中R1，R2，R3和R4独立地选自H、C1-C12烷基、任意地被羟基取代的C1-C12烷氧基，条件是R1，R2，R3和R4不同时为H。
4.权利要求3的方法，其中R1，R2，R3和R4选自H、C1-C4烷基、任意地被羟基取代的C1-C4烷氧基。
5.权利要求1-4的方法，其中溶剂试剂选自：二醇、甘油、(聚)亚烷基二醇、DMSO和聚山梨酸酯80。
6.权利要求1-5的方法，其中溶液包括1-80％，优选10-70％，更优选40-60％溶剂试剂。
7.权利要求1-6的方法，其中溶液是水溶液。
8.权利要求1-7的方法，其中酸溶液的pH为0-4，优选0.2-2.5，更优选0.8-1.0。
9.权利要求1-8的方法，其中将形成的原硅酸与非毒性微粒载体接触。
10.权利要求9的方法，其中在微粒载体存在下原位形成原硅酸。
11.权利要求9或10的方法，其中将载体，在与原硅酸接触之后挤出。
12.权利要求9-11的方法，其中硅制剂的硅含量为0.01-50wt％，优选0.01-10wt％，更优选0.1-10wt％，最优选0.1-5wt％。
13.权利要求9-12的方法，其中硅制剂在8小时内的总硅吸收量大于250(μg)硅h/l，优选大于500(μg)硅h/l，更优选大于600(μg)硅h/l，如250-700(μg)硅h/l，优选300-700(μg)硅h/l。
14.在权利要求1-8中形成的或在权利要求9-13中生产的硅制剂在动物饲料、食品、食品或饲料补充物、和药物或化妆品制剂生产中的用途。
15.可通过权利要求1-8的方法获得的原硅酸。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99204496.6 | 1999-12-24 | ||
| EP99204496A EP1110909A1 (en) | 1999-12-24 | 1999-12-24 | Method for preparing ortho silicic acid, ortho silicic acid as obtained, and its use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007103059149A Division CN101199318B (zh) | 1999-12-24 | 2000-12-18 | 原硅酸的制备方法,获得的原硅酸,和它的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1420843A true CN1420843A (zh) | 2003-05-28 |
| CN100368292C CN100368292C (zh) | 2008-02-13 |
Family
ID=8241064
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB008182566A Expired - Lifetime CN100368292C (zh) | 1999-12-24 | 2000-12-18 | 原硅酸的制备方法,获得的原硅酸,和它的用途 |
| CN2007103059149A Expired - Lifetime CN101199318B (zh) | 1999-12-24 | 2000-12-18 | 原硅酸的制备方法,获得的原硅酸,和它的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007103059149A Expired - Lifetime CN101199318B (zh) | 1999-12-24 | 2000-12-18 | 原硅酸的制备方法,获得的原硅酸,和它的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20030099676A1 (zh) |
| EP (2) | EP1110909A1 (zh) |
| JP (1) | JP4454200B2 (zh) |
| CN (2) | CN100368292C (zh) |
| AT (1) | ATE294137T1 (zh) |
| AU (1) | AU783216B2 (zh) |
| CA (1) | CA2394987C (zh) |
| DE (1) | DE60019805T2 (zh) |
| ES (1) | ES2237492T3 (zh) |
| IL (2) | IL150370A0 (zh) |
| WO (1) | WO2001047807A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665447A (zh) * | 2009-07-23 | 2012-09-12 | 埃维昂矿泉水有限公司 | 用于制备富含天然原硅酸的水的方法 |
| CN102892292A (zh) * | 2010-03-31 | 2013-01-23 | 塔明克公司 | 稳定的生物可利用的可溶的硅酸盐溶液 |
| CN104161770A (zh) * | 2013-05-17 | 2014-11-26 | 蒋临沂 | 一种硅酸络合物 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1371289A1 (en) * | 2002-03-20 | 2003-12-17 | Bio Minerals N.V. | Choline-silicic acid complex |
| US9078465B2 (en) | 2002-03-20 | 2015-07-14 | Bio Minerals N.V. | Choline-silicic acid complex with osmolytes and divalent trace elements |
| EP1391426A1 (en) * | 2002-08-12 | 2004-02-25 | Bio Minerals N.V. | Method for the preparation of a silicic acid comprising extrudate, said extrudate, its use and a pharmaceutical composition comprising the said extrudate |
| WO2007139162A1 (ja) * | 2006-05-31 | 2007-12-06 | Incorporated Administrative Agency Fisheries Research Agency | 藻類用ケイ酸成分供給剤、および藻類へのケイ酸成分供給方法 |
| GB0805279D0 (en) * | 2008-03-20 | 2008-04-30 | Univ Nottingham Trent | Food supplement |
| WO2009127256A1 (en) * | 2008-04-17 | 2009-10-22 | Jisbrey, S.A | Hydronium stabilized and dissoluble silicic acid nanoparticles: preparation, stabilization and use |
| GB0913255D0 (en) * | 2009-07-30 | 2009-09-02 | Sisaf Ltd | Topical composition |
| CN102389107B (zh) * | 2011-07-25 | 2013-03-20 | 吉林大学 | 利用富硅植物制备正硅酸提取液和硅补充剂的方法 |
| PL403902A1 (pl) * | 2013-05-15 | 2014-11-24 | Przedsiębiorstwo Intermag Spółka Z Ograniczoną Odpowiedzialnością | Preparat krzemowy o właściwościach stymulujących rozwój roślin, sposób wytwarzania preparatu krzemowego stymulującego rozwój roślin i jego zastosowanie |
| DE102015214140A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| DE102015214137A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| DE102015214143A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| DE102015214145A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| DE102015214146A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| DE102015214144A1 (de) * | 2015-07-27 | 2017-02-02 | Beiersdorf Ag | Schweiß verringernde kosmetische Zubereitung |
| NL2017436B1 (nl) * | 2015-09-09 | 2017-09-20 | Bio Science B V | Emulsies bevattende siliciumzuur |
| WO2019150382A1 (en) * | 2018-01-30 | 2019-08-08 | Privi Life Science Private Limited | A method for preparation of othro silicic acid for agriculture |
| PL238905B1 (pl) * | 2018-02-16 | 2021-10-18 | Centrum Badawczo Rozwojowe Glokor Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania koncentratu do produkcji napoju prozdrowotnego zawierającego związki krzemu, stosowanego jako enterotransporter lub enterosorbent oraz modułowa instalacja do wytwarzania koncentratu |
| EP3632449A1 (en) * | 2018-10-05 | 2020-04-08 | Bio Minerals N.V. | Silicic acids for use in the treatment of periodontitis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU540654A1 (ru) * | 1974-01-11 | 1976-12-30 | Институт Физической Химии Им.Л.В.Писаржеского Ан Украинской Сср | Способ получени гигроскопического пленочного адсорбента на основе кремневой кислоты |
| DE2654358C2 (de) * | 1976-12-01 | 1985-01-10 | Chemische Werke Hüls AG, 4370 Marl | Verfahren zur Herstellung von pulverförmigen, rieselfähigen, gegebenenfalls Weichmacheröl enthaltenden Kautschuk-Füllstoff-Mischungen |
| US4200548A (en) * | 1976-08-02 | 1980-04-29 | Elektrokemiska Aktiebolaget | Silicic acid detergent product for microdeposition of silicic acid on textiles |
| JPH07484B2 (ja) * | 1990-06-27 | 1995-01-11 | 有限会社アキヤマ | ｐＨ５〜７の珪酸水溶液 |
| US5186743A (en) * | 1990-12-13 | 1993-02-16 | Akzo N.V. | Low volatile organic content hybrid silica binder |
| JP2594222B2 (ja) * | 1993-09-28 | 1997-03-26 | 日本臓器製薬株式会社 | 新規生理活性物質−ｋｆ |
| NL9400189A (nl) * | 1994-02-07 | 1995-09-01 | Bio Pharma Sciences Bv | Gestabiliseerd orthosiliciumzuur bevattend preparaat, een werkwijze voor het bereiden daarvan en een biologisch preparaat. |
| US6160067A (en) * | 1995-10-03 | 2000-12-12 | Dsm N.V. | Reactive silica particles, process for manufacturing the same, use of the same |
| US5807607A (en) * | 1995-11-16 | 1998-09-15 | Texas Instruments Incorporated | Polyol-based method for forming thin film aerogels on semiconductor substrates |
| JP3524658B2 (ja) * | 1995-11-27 | 2004-05-10 | 株式会社ナリス化粧品 | 化粧料用粉体及び化粧料 |
| US6495352B1 (en) * | 1999-04-15 | 2002-12-17 | Sandia Corporation | Sol-gel method for encapsulating molecules |
| US6318124B1 (en) * | 1999-08-23 | 2001-11-20 | Alliedsignal Inc. | Nanoporous silica treated with siloxane polymers for ULSI applications |
-
1999
- 1999-12-24 EP EP99204496A patent/EP1110909A1/en not_active Withdrawn
-
2000
- 2000-12-18 US US10/168,599 patent/US20030099676A1/en not_active Abandoned
- 2000-12-18 ES ES00990794T patent/ES2237492T3/es not_active Expired - Lifetime
- 2000-12-18 AT AT00990794T patent/ATE294137T1/de active
- 2000-12-18 CA CA002394987A patent/CA2394987C/en not_active Expired - Lifetime
- 2000-12-18 CN CNB008182566A patent/CN100368292C/zh not_active Expired - Lifetime
- 2000-12-18 EP EP00990794A patent/EP1242307B1/en not_active Expired - Lifetime
- 2000-12-18 JP JP2001549291A patent/JP4454200B2/ja not_active Expired - Lifetime
- 2000-12-18 CN CN2007103059149A patent/CN101199318B/zh not_active Expired - Lifetime
- 2000-12-18 DE DE60019805T patent/DE60019805T2/de not_active Expired - Lifetime
- 2000-12-18 WO PCT/EP2000/012929 patent/WO2001047807A1/en active IP Right Grant
- 2000-12-18 AU AU30143/01A patent/AU783216B2/en not_active Expired
- 2000-12-18 IL IL15037000A patent/IL150370A0/xx active IP Right Grant
-
2002
- 2002-06-23 IL IL150370A patent/IL150370A/en unknown
-
2009
- 2009-09-17 US US12/561,812 patent/US20100068294A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665447A (zh) * | 2009-07-23 | 2012-09-12 | 埃维昂矿泉水有限公司 | 用于制备富含天然原硅酸的水的方法 |
| CN102665447B (zh) * | 2009-07-23 | 2014-03-19 | 埃维昂矿泉水有限公司 | 用于制备富含天然原硅酸的水的方法 |
| CN102892292A (zh) * | 2010-03-31 | 2013-01-23 | 塔明克公司 | 稳定的生物可利用的可溶的硅酸盐溶液 |
| CN104161770A (zh) * | 2013-05-17 | 2014-11-26 | 蒋临沂 | 一种硅酸络合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242307A1 (en) | 2002-09-25 |
| JP2003519068A (ja) | 2003-06-17 |
| JP4454200B2 (ja) | 2010-04-21 |
| IL150370A (en) | 2006-06-11 |
| DE60019805T2 (de) | 2006-02-02 |
| CN101199318A (zh) | 2008-06-18 |
| AU783216B2 (en) | 2005-10-06 |
| CN100368292C (zh) | 2008-02-13 |
| EP1110909A1 (en) | 2001-06-27 |
| AU3014301A (en) | 2001-07-09 |
| CA2394987A1 (en) | 2001-07-05 |
| US20030099676A1 (en) | 2003-05-29 |
| WO2001047807A8 (en) | 2001-07-26 |
| ATE294137T1 (de) | 2005-05-15 |
| ES2237492T3 (es) | 2005-08-01 |
| CN101199318B (zh) | 2012-07-18 |
| DE60019805D1 (de) | 2005-06-02 |
| US20100068294A1 (en) | 2010-03-18 |
| WO2001047807A1 (en) | 2001-07-05 |
| CA2394987C (en) | 2009-11-03 |
| IL150370A0 (en) | 2002-12-01 |
| EP1242307B1 (en) | 2005-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100368292C (zh) | 原硅酸的制备方法,获得的原硅酸,和它的用途 | |
| JP3665345B2 (ja) | 水性媒質からのリン酸塩に対する吸着剤、その製造および使用 | |
| JP5128760B2 (ja) | ダイエタリー製品において栄養補助剤として使用するためのγ−ポリグルタミン酸（γ−ＰＧＡ、Ｈ体）及びγ−ポリグルタメート | |
| JP2003522822A (ja) | 栄養性の改良されたイヌリン製品 | |
| JP2010265309A (ja) | ケイ酸含有押出物の製造方法、前記押出物、その使用、及び前記押出物を含む医薬組成物 | |
| HU192579B (en) | Process for preparing orally administrable immunogenic composition | |
| CN1202130C (zh) | 呈固态、稳定和浓缩形式的基于可生物吸收原硅酸的络合物及其制备方法 | |
| EP1757268B1 (en) | Dry-form composition for oral ingestion and gel-form composition for oral ingestion of type prepared at time of use | |
| CN1872342A (zh) | 用寡糖溶液制造粒状经口组合物的方法 | |
| US20110046085A1 (en) | Oral Immunostimulation of Fish from (1-4) Linked Beta-D-Mannuronic Acid | |
| CN1929752A (zh) | 含有食物纤维的健康食品的制造方法 | |
| CN1835733A (zh) | 天然的番茄红素浓缩物及其制备方法 | |
| CN1895282A (zh) | 一种钙补充剂及其制备方法 | |
| CN1101684C (zh) | 蜂蛹钙制剂 | |
| JP4889978B2 (ja) | 経口摂取用組成物 | |
| CN1112184C (zh) | 褪黑素缓释制剂及其生产工艺 | |
| JPH0651628B2 (ja) | 栄養剤組成物 | |
| CN1287805C (zh) | 抗衰老片剂的配方及制作方法 | |
| CN1063926C (zh) | 促钙吸收作用的林蛙卵组合物及其制剂 | |
| CN1369271A (zh) | 蜂胎素及其制备方法 | |
| CN1765882A (zh) | 水溶性维生素d2的制备方法 | |
| CN117617402A (zh) | 一种增强宠物免疫力的茯苓营养粉及其制备方法 | |
| CN1119917A (zh) | 珍珠、鲨鱼骨、牡蛎壳、乌贼骨软化蜜及其系列产品的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080213 |