CN1835733A - 天然的番茄红素浓缩物及其制备方法 - Google Patents
天然的番茄红素浓缩物及其制备方法 Download PDFInfo
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Abstract
本发明涉及由一种植物组织在碱化、固/液分离、酸化和第二次固/液分离后得到的一种天然番茄红素浓缩物。这样得到的浓缩物具有较高的生物利用度，并且在室温下是水溶性的。
Description
本发明涉及一种天然的番茄红素浓缩物及其制备方法与用途。
番茄红素是一种在番茄中大量存在的天然颜料，而且在甜瓜、番石榴、西瓜或柚子中也存在番茄红素。它们的生物活性、特别是其抗氧化作用已为人们所知。
市场上有许多含有番茄红素制品。这些制品一般呈含油树脂和番茄红素形式，它们含有的含油树脂和番茄红素的生物利用率相当有限。此外，这种番茄红素是用有机溶剂提取的，因此，可能在其成品中存在微量的所述溶剂。
事实上，EP 1 103 579为了提高番茄红素的生物利用率而描述了一种番茄红素与血清蛋白溶液的混合物。所描述的番茄红素是用至少一种溶剂提取的。
WO 03/041 678描述了一种番茄红素，它是通过添加不同的添加剂，例如油类或表面活性剂来提高生物利用率的。描述的番茄红素用一些溶剂进行处理。
另外，JP 54024940描述了一种从番茄残留物，例如种子或皮浓缩番茄红素的方法。该方法利用这些残留物的内源酶起作用，从而使生物组织发生降解，以有利于番茄红素的提取。在45-60℃温度下温育5小时可诱发这种酶活性。然后，采用过滤分离皮与种子，接着对各种不需要的不溶物进行分段絮凝，由此提取得到番茄红素。
本发明的目的是提供一种具有提高的生物利用率的“天然”产品，即这种产品只是进行了没有改变自然特征的技术处理。
此外，本发明的提取方法简单、快速且又十分经济，并且在任何情况下都不会受到原料内源酶存在状态的制约。
本发明涉及一种天然的番茄红素浓缩物，所述的浓缩物在室温下是水溶性的，更确切地说是水可分散的，而且番茄红素在此时仍是油溶性的。不添加表面活性剂就能获得这种水溶解性。
可以由任何含有番茄红素的植物，如番茄、甜瓜、西瓜、番石榴、柚子、杏子、蔷薇果得到这种浓缩物。
在使用番茄的情况下，使用的原料可以是一种番茄酱。
在本说明书中，番茄酱应该理解是含有蛋白质、碳水化合物、多糖、脂溶化合物，例如类胡萝卜素，特别是番茄红素，以及有机酸的番茄浓缩提取物。
在本发明的组合物中，按照最初的番茄红素的浓度来选择番茄酱。事实上，浓缩物中的番茄红素含量取决于原料中该化合物的起始含量。
本发明的浓缩物每g所述浓缩物含有至少1mg番茄红素。这种浓缩物每g浓缩物优选含有1mg-40mg番茄红素，更优选每g浓缩物含有10-30mg番茄红素。
这种浓缩物还含有多达30％蛋白质，多达30％多糖，多达10％有机酸，至少30％脂溶化合物，0.0001-2％番茄红素，更优选0.001-1％番茄红素。
这些百分数是以干重计给出的。
本发明的组合物可以呈粉状、液体或胶凝形式。
在浓缩物为液体形式的情况下，所述的浓缩物含有至少35％水。更优选所述的浓缩物含有60-95％水。
正如前面已提到的，本发明的两个重要特征是其是一种具有令人满意的生物利用率的番茄红素浓缩物，并且易于使用，因为在粉末的情况下，这种浓缩物在室温下是一种水溶性的番茄红素粉末，更确切地说是水分散性的番茄红素粉末。
为了保持产品的自然性以为消费者提供具有高生物活性的浓缩物，在该方法的实施过程中不使用溶剂。
本发明的浓缩番茄红素的较好生物利用率可用下述事实进行解释：按照本发明的方法所得到的晶体尺寸是含油树脂结晶形态尺寸的5-10分之一。考虑到使用的原料，在这种情况下为番茄酱，而它是番茄红素生物利用最高的资源，因为在其生产期间它受到不同的技术处理。
含油树脂应该理解是一种含有类胡萝卜素，像番茄红素、三甘油酯、磷脂、生育酚和其它更少化合物的植物类脂提取物。
本发明的粉末或凝胶或溶液还可以含有添加的维生素E和/或维生素C。
本发明还涉及生产上述浓缩物的方法，其中：
-对含有亲油性化合物的植物组织进行碱化，
-加热碱化溶液至沸腾，保持沸腾1-60分钟，
-采用固-液分离方法，优选地采用热过滤方法分离纤维和各种不溶的化合物，
-得到的溶液进行酸化，
-采用固-液分离方法，优选地采用离心法分离碳水化合物和其它可溶化合物。
植物组织应该理解为是一种通过降低水含量所得到的所述植物酱。
根据该方法第一个实施方案得到一种液体。这种液体具有一种流变流态化(rhéofluidifiant)性能，其粘度在剪切速率160s-1下为90-120mPa.s。该粘度值是使用Couette几何学RheoStress 150仪在恒定温度20.5℃与剪切速率由1s-1增加到1000s-1的条件下测量的。
为了得到一种凝胶，可以添加钙对所述的液体进行处理，添加钙的目的在于使多糖胶凝化。在该方法的第二个实施方案中，可以采用雾化或冻干法干燥该浓缩物，从而得到一种粉末。
可以其不同的形式或以混合方式直接地使用本发明的组合物。
可以使用每g产物含有至少0.1mg番茄红素的番茄酱，该酱的pH是3.5-5，更优选为4-4.5。用软化水和NaOH类的碱将这种酱碱化直至pH达到6-9。
将这种制品混合，同时加热至沸腾温度。这种沸腾保持1-60分钟，更优选地保持2-30分钟。
然后，进行固-液分离，从而分离纤维和其它不溶化合物，更优选进行热过滤。
回收的滤液是一种含有分散番茄红素的溶液。用一种柠檬酸类的酸进行酸化至pH为3.5-5，更优选为4-4.5。
将这种制品进行混合，然后进行固-液分离，以回收碳水化合物和其它可溶化合物，更优选地进行离心分离。
得到的溶液是本发明的一种番茄红素浓缩物。可以用软化水和一种NaOH类的碱将其pH调到中性，同时进行混合。
该番茄红素仍保持水溶性，因为它已被介质中的蛋白质以及被多糖络合。
取决于所需的物理形式，或者使用原样番茄红素浓缩物，或者使用液体形式的番茄红素浓缩物。
当呈胶凝形式时，可将钙添加到复合物中，以使多糖产生胶凝化。
最后，为了得到一种粉末，可以采用雾化方法或本技术领域的技术人员已知的任何其它方法干燥这种浓缩物。
本发明还涉及前面所述粉末在美容组合物中的用途，目的在于延缓皮肤衰老和/或皮肤暴露于紫外线时发生的皮肤损伤，所述的组合物含有至少10-10％番茄红素。
这种局部可用的组合物还可以含有美容可接受的脂肪或油。还可以添加其它的美容活性组分。该组合物还可以含有结构剂、表面活性剂、赋形剂、着色剂、香料、磨料或遮光剂。
本发明的组合物含有10-10-10％番茄红素，更优选该美容组合物含有10-8-5％番茄红素。
本发明还涉及番茄红素浓缩物在采用口服的口服组合物中的用途，以便利用这种形式的番茄红素的高生物利用率。其目的是产生光保护和延缓皮肤衰老。能含有这种浓缩物的介质可以是：饮料、巧克力、冰冻饮料或冰淇淋、谷物制品、速溶咖啡或外卖菜肴。
在这种情况下，所述粉溶于上述介质中，达到日服剂量0.001-50mg番茄红素。优选的日服剂量是2mg-10mg。
本发明还可以呈丸剂、胶囊或片剂形式，其剂量是0.001-100％所述浓缩物。这些产品这时可以直接用水或采用任何其它的已知方法服用。
最后，这种浓缩物可以考虑用作防止皮肤过度暴露紫外线时出现皮肤病的产品。在这种情况下，可以采用口服或局部用药的方式使用。
下面用实施例进一步说明本发明：
实施例1：制备粉末形式的浓缩物
在一批中，将50kg pH4.3的番茄酱与100kg软化水混合。在温度25℃下进行混合。用NaOH将其pH调节到7。
这种溶液加热至沸腾，并且保持沸腾5分钟。
使这种溶液在室温下静置15分钟，然后用Westfalia型倾析器进行热过滤。
回收的滤液用温度15℃的水进行冷却。用柠檬酸将这种溶液酸化多达pH4.3，同时混合这种溶液。
然后，使用每分钟14 000转的Padberg型离心机离心分离这种溶液。
回收沉淀，用NaOH将其pH调节到7.00。
最后，使用NIRO型雾化器雾化所得到的溶液，其雾化器的进口温度110-130℃，出口温度70-80℃。根据所需的粉末细度，雾化喷嘴的旋转速度是每分钟24 000-30 000转。
回收本发明的浓缩物。
实施例2：美容组合物
制备一种面霜，它含有7％凡士林油、2％实施例1的浓缩物粉末、3％单硬脂酸甘油酯、聚乙二醇硬脂酸酯、0.4％羧乙烯基聚合物、0.7％硬脂醇、3％大豆蛋白、0.4％NaOH、防腐剂，用水补充到100。
实施例3：美容组合物
制备一种护面凝胶，它含有10％甘油、2％实施例1的浓缩物粉末、1％cocoamphodiacétate二钠、防腐剂，用水补充到100。
Claims (13)
1、天然的番茄红素浓缩物，其特征在于：
A-它在室温下是水溶性的，
B-每g所述浓缩物含有至少1mg番茄红素，多达30％蛋白质、多达30％多糖、多达10％有机酸和至少30％脂类化合物。
2、根据权利要求1所述的浓缩物，其特征在于该浓缩物呈粉状、液体或胶凝形式。
3、根据权利要求1所述的浓缩物，其特征在于该浓缩物还含有维生素E和/或维生素C。
4、根据权利要求1-3中任一项所述的浓缩物，其特征在于每g浓缩物含有1mg-40mg番茄红素。
5、根据权利要求4所述的浓缩物，其特征在于每g浓缩物优选含有10mg-30mg番茄红素。
6、制备根据权利要求1-5中任一项所述的浓缩物的方法，其中：
-对含有亲油性化合物的植物组织进行碱化，
-加热所述碱化溶液至沸腾，保持沸腾1-60分钟，
-采用固-液分离方法分离纤维和各种不溶的化合物，
-酸化得到的复合物，
-采用固-液分离方法分离碳水化合物和可溶的化合物。
7、根据权利要求6所述的方法，其特征在于往所述复合物中添加钙，得到一种凝胶。
8、根据权利要求6所述的方法，其特征在于采用雾化或冻干方法干燥所述乳液，得到一种粉末。
9、根据权利要求1-8中任一项所述的浓缩物在美容组合物中的用途，目的在于延缓皮肤衰老和/或防止皮肤暴露于紫外线时可能发生的皮肤损伤，所述的组合物含有至少10-10％番茄红素。
10、根据权利要求1-8中任一项所述的浓缩物在优化例如在饮料、巧克力、冰冻饮料或冰淇淋、谷物制品、速溶咖啡或外卖菜肴中的番茄红素吸收而采用口服的口服组合物中的用途，以便产生光保护，并因此延缓皮肤衰老。
11、根据权利要求1-8中任一项所述的浓缩物作为丸剂、胶囊或片剂形式的食品补充剂的用途，其剂量是0.001-100％所述浓缩物。
12、采用口服或局部用药的根据权利要求1-8中任一项所述的浓缩物，在避免皮肤在暴露于紫外线时而出现任何皮肤病中的用途。
13、根据权利要求6-8中任一项所述方法可得到的产品。
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| EP03018982.3 | 2003-08-21 |
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| CN103536506A (zh) * | 2013-10-15 | 2014-01-29 | 倪生标 | 一种防晒乳液 |
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| CA2580867A1 (en) * | 2004-10-26 | 2006-05-04 | Lycored Natural Products Industries Ltd. | A method for fortifying food stuff with phytonutrients and food products obtained thereby |
| MY147363A (en) * | 2005-09-20 | 2012-11-30 | Nestec Sa | Water dispersible composition and method for preparing same |
| KR100845317B1 (ko) * | 2007-01-23 | 2008-07-10 | 한국식품연구원 | 마이크로이멀젼 기법에 의한 라이코펜 회수 및 수용화 |
| GB0819959D0 (en) | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
| IN2014MN02392A (zh) | 2012-04-23 | 2015-08-21 | Univ Oslo | |
| JP6012415B2 (ja) * | 2012-11-09 | 2016-10-25 | アサヒグループホールディングス株式会社 | 酒酔い軽減剤 |
| GB201223365D0 (en) | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
| BR112015017355A2 (pt) * | 2013-01-22 | 2017-07-11 | Lycored Ltd | composição terapêutica, método para inibir ou reduzir a produção de um mediador anti-inflamatório em um indivíduo, método de tratamento de condições patológicas e método para melhorar a saúde óssea em um indivíduo |
| US20150327718A1 (en) | 2014-02-14 | 2015-11-19 | Remington Designs, Llc | Apparatuses and methods for solute extraction |
| EP3534725A1 (en) | 2016-11-02 | 2019-09-11 | Provexis Natural Products Limited | Water soluble tomato extract protects against adverse effects of air pollution |
| KR102081489B1 (ko) | 2017-11-28 | 2020-02-26 | 신라대학교 산학협력단 | 알카리 가수분해 및 염석결정화를 이용한 토마토로부터 수용성 라이코펜 제조 및 라이코펜 분말 수득방법 |
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| US2890231A (en) * | 1955-09-20 | 1959-06-09 | Weyerhaeuse Timber Company | Alkaline extraction of chemical products from bark |
| US2938893A (en) * | 1955-12-28 | 1960-05-31 | Rayonier Inc | Alkali bark derivative |
| JPS5424940A (en) * | 1977-07-26 | 1979-02-24 | Kagome Kk | Production of carotinoid containing substance for coloring food |
| US5837311A (en) * | 1993-12-13 | 1998-11-17 | Makhteshim Chemical Works Ltd. | Industrial processing of tomatoes and product thereof |
| JP3291148B2 (ja) * | 1994-11-30 | 2002-06-10 | カネボウフーズ株式会社 | ゼリー及びその製法 |
| JP2836017B2 (ja) | 1995-06-13 | 1998-12-14 | カゴメ株式会社 | 低粘性トマトジュースの製造方法 |
| JP3606702B2 (ja) * | 1997-04-08 | 2005-01-05 | カゴメ株式会社 | 低粘度で高リコピン含量の食品材料の製造方法 |
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| JP2000302995A (ja) * | 1999-04-23 | 2000-10-31 | Nippon Del Monte Corp | 乳化トマト色素の製造方法 |
| EP1051918A1 (en) * | 1999-05-12 | 2000-11-15 | Société des Produits Nestlé S.A. | Method for extracting carotenoids and other anti-oxidants; extracts obtained by this method; food and pet food containing these extracts |
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| JP2002125619A (ja) * | 2000-10-31 | 2002-05-08 | Kikkoman Corp | リコペン組成物、その製法及び用途 |
| ES2172442B2 (es) * | 2000-11-15 | 2003-12-01 | Univ Extremadura | Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado. |
| FR2825277B1 (fr) * | 2001-05-30 | 2004-10-15 | Oreal | Composition cosmetique et/ou dermatologique et/ou pharmaceutique contenant au moins un compose ihnibiteur de l'enzime 3, b-hsd |
| IL146496A0 (en) * | 2001-11-14 | 2002-07-25 | Lycored Natural Prod Ind Ltd | Carotenoid composition and method for protecting skin |
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- 2004-08-20 KR KR1020067003440A patent/KR20060097107A/ko not_active Application Discontinuation
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103536506A (zh) * | 2013-10-15 | 2014-01-29 | 倪生标 | 一种防晒乳液 |
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| JP4814094B2 (ja) | 2011-11-09 |
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| CN100431523C (zh) | 2008-11-12 |
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| US8507014B2 (en) | 2013-08-13 |
| PL379091A1 (pl) | 2006-06-26 |
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| KR20060097107A (ko) | 2006-09-13 |
| US20120027878A1 (en) | 2012-02-02 |
| CA2536240A1 (en) | 2005-03-10 |
| EP1508325A1 (fr) | 2005-02-23 |
| WO2005020948A1 (fr) | 2005-03-10 |
| JP2007502800A (ja) | 2007-02-15 |
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