JP4814094B2 - 天然リコピン濃縮物及び製造方法 - Google Patents
天然リコピン濃縮物及び製造方法 Download PDFInfo
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- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title claims abstract description 61
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title claims abstract description 61
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 61
- 235000012661 lycopene Nutrition 0.000 title claims abstract description 61
- 229960004999 lycopene Drugs 0.000 title claims abstract description 61
- 239000001751 lycopene Substances 0.000 title claims abstract description 61
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title claims abstract description 61
- 239000012141 concentrate Substances 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 238000000926 separation method Methods 0.000 claims abstract description 9
- 150000004676 glycans Chemical class 0.000 claims abstract description 8
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 8
- 239000005017 polysaccharide Substances 0.000 claims abstract description 8
- 238000009835 boiling Methods 0.000 claims abstract description 7
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 6
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- 239000007787 solid Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- 241000196324 Embryophyta Species 0.000 claims description 7
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- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 6
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
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- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims description 3
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 2
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
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- 229940001941 soy protein Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
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- 235000019149 tocopherols Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
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- General Health & Medical Sciences (AREA)
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- Mycology (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
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- Botany (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Description
親油性化合物を含有する植物構造体をアルカリ化し、
そのアルカリ化した溶液を沸騰温度に加熱し、1分間乃至60分間維持し、
繊維及び種々の不溶性化合物を固体−液体分離により、好ましくは高温状態における濾過により、単離し、
得られた溶液を酸性化し、
炭水化物及び他の可溶性化合物を固体−液体分離により、好ましくは遠心分離により単離する、
先に記載した濃縮物を製造する方法に関する。
一回分において、50kgのpH4.3におけるトマトピューレを100kgの脱イオン水と混合する。25℃の温度において、この混合を行う。NaOHでpHを7にする。
7%の液体パラフィン、2%の実施例1による粉末、3%のグリセリルモノステアレート、ポリエチレングリコールステアレート、0.4%のカルボキシビニルポリマー、0.7%のステアリルアルコール、3%の大豆蛋白質、0.4%のNaOH、保存剤を含有し、100までの残余が水である美容乳液を調整する。
10%のグリセリン、2%の実施例1による粉末、1%のココアンフォ二酢酸二ナトリウム、保存剤を含有し、100までの残余が水である美容ゲルを調整する。
Claims (10)
- 水含量を低減させることにより得られる、リコピン含有植物ペーストをアルカリ化し、
そのアルカリ化した溶液を沸騰温度に加熱し、1分間乃至60分間維持し、
繊維及び種々の不溶性化合物を固体−液体分離により単離し、
得られたリコピンと蛋白質と多糖類との複合体を含む溶液を、3.5〜5のpHに酸性化し、
炭水化物及び他の可溶性化合物を固体−液体分離により単離し、前記複合体を含むリコピン濃縮液を得ることを含む、天然リコピン濃縮物を製造する方法であって、
前記植物は、トマト、メロン、スイカ、グァバ、グレープフルーツ、アプリコット、及びローズヒップから選択される方法。 - ゲルを得るために前記リコピン濃縮液にカルシウムを添加することを特徴とする、請求項1に記載の方法。
- 粉末を得るために噴霧乾燥又は凍結乾燥により前記リコピン濃縮液を乾燥させることを特徴とする、請求項1に記載の方法。
- 請求項1〜3のいずれか1項に記載の方法により得られる、室温において水溶性であり、リコピン、蛋白質、多糖類、有機酸、及びリコピン以外の脂質化合物を含有する、天然リコピン濃縮物。
- 微粉形態、液体形態又はゲル形態で提供される、請求項4に記載の天然リコピン濃縮物。
- 付加的にビタミンE及び/又はビタミンCを含有し得る、請求項4に記載の天然リコピン濃縮物。
- 少なくとも10−10%のリコピンを含有する、UVへの暴露によりもたらされ得る皮膚の老化を遅延させるため及び/又は皮膚ダメージと戦うための化粧品組成物における、請求項4〜6のいずれか1項に記載の天然リコピン濃縮物の使用。
- 光保護を誘導し、従って、皮膚の老化を遅延させるようにリコピンの吸収を最適化するために経口的に摂取され得る組成物における、請求項4〜6のいずれか1項に記載の天然リコピン濃縮物の使用。
- 0.001%乃至100%の用量の請求項4〜6のいずれか1項に記載の天然リコピン濃縮物を含有する丸薬、ゼラチンカプセル又は錠剤の形態における補助食品としての、請求項4〜6のいずれか1項に記載の天然リコピン濃縮物の使用。
- UVへの暴露に関連づけられる皮膚状態を回避するための経口的な又は局所的な、請求項4〜6のいずれか1項に記載の天然リコピン濃縮物の使用。
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EP03018982.3 | 2003-08-21 | ||
EP03018982A EP1508325B1 (fr) | 2003-08-21 | 2003-08-21 | Concentré naturel de Lycopène et procédé d'obtention |
PCT/EP2004/009349 WO2005020948A1 (fr) | 2003-08-21 | 2004-08-20 | Concentre naturel de lycopene et procede d’obtention |
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JP2007502800A JP2007502800A (ja) | 2007-02-15 |
JP4814094B2 true JP4814094B2 (ja) | 2011-11-09 |
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JP2006523614A Expired - Fee Related JP4814094B2 (ja) | 2003-08-21 | 2004-08-20 | 天然リコピン濃縮物及び製造方法 |
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US (3) | US20060286187A1 (ja) |
EP (1) | EP1508325B1 (ja) |
JP (1) | JP4814094B2 (ja) |
KR (1) | KR20060097107A (ja) |
CN (1) | CN100431523C (ja) |
AT (1) | ATE424898T1 (ja) |
AU (1) | AU2004267942B2 (ja) |
BR (1) | BRPI0413691A (ja) |
CA (1) | CA2536240C (ja) |
DE (1) | DE60326571D1 (ja) |
ES (1) | ES2322757T3 (ja) |
PL (1) | PL379091A1 (ja) |
WO (1) | WO2005020948A1 (ja) |
ZA (1) | ZA200602277B (ja) |
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GB0819959D0 (en) * | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Fruit extracts |
WO2013163057A1 (en) | 2012-04-23 | 2013-10-31 | University Of Oslo | Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract |
JP6012415B2 (ja) * | 2012-11-09 | 2016-10-25 | アサヒグループホールディングス株式会社 | 酒酔い軽減剤 |
GB201223365D0 (en) | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
MX2015009385A (es) * | 2013-01-22 | 2015-09-23 | Lycored Ltd | Composiciones que comprenden concentrado de tomate claro tratado con calor. |
CN103536506A (zh) * | 2013-10-15 | 2014-01-29 | 倪生标 | 一种防晒乳液 |
US20150327718A1 (en) | 2014-02-14 | 2015-11-19 | Remington Designs, Llc | Apparatuses and methods for solute extraction |
AU2017353349B2 (en) | 2016-11-02 | 2022-04-21 | Provexis Natural Products Limited | Water soluble tomato extract protects against adverse effects of air pollution |
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Also Published As
Publication number | Publication date |
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CA2536240C (en) | 2013-02-05 |
AU2004267942B2 (en) | 2009-10-08 |
EP1508325B1 (fr) | 2009-03-11 |
US20060286187A1 (en) | 2006-12-21 |
WO2005020948A1 (fr) | 2005-03-10 |
KR20060097107A (ko) | 2006-09-13 |
US8795743B2 (en) | 2014-08-05 |
CN1835733A (zh) | 2006-09-20 |
ATE424898T1 (de) | 2009-03-15 |
EP1508325A1 (fr) | 2005-02-23 |
ES2322757T3 (es) | 2009-06-26 |
JP2007502800A (ja) | 2007-02-15 |
AU2004267942A1 (en) | 2005-03-10 |
US20130296420A1 (en) | 2013-11-07 |
US20120027878A1 (en) | 2012-02-02 |
US8507014B2 (en) | 2013-08-13 |
CN100431523C (zh) | 2008-11-12 |
DE60326571D1 (de) | 2009-04-23 |
BRPI0413691A (pt) | 2006-10-24 |
CA2536240A1 (en) | 2005-03-10 |
ZA200602277B (en) | 2007-05-30 |
PL379091A1 (pl) | 2006-06-26 |
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