CN1359294A - 含有乙酰水杨酸和氯吡格雷硫酸氢盐的单位剂型形药物组合物 - Google Patents

含有乙酰水杨酸和氯吡格雷硫酸氢盐的单位剂型形药物组合物 Download PDF

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Publication number
CN1359294A
CN1359294A CN00807001A CN00807001A CN1359294A CN 1359294 A CN1359294 A CN 1359294A CN 00807001 A CN00807001 A CN 00807001A CN 00807001 A CN00807001 A CN 00807001A CN 1359294 A CN1359294 A CN 1359294A
Authority
CN
China
Prior art keywords
pharmaceutical composition
clopidogrel
aspirin
clopidogrel hydrogenesulphate
hydrogenesulphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00807001A
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English (en)
Chinese (zh)
Inventor
B·阿布拉默维奇
J·莱里蒂尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of CN1359294A publication Critical patent/CN1359294A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN00807001A 1999-04-30 2000-04-25 含有乙酰水杨酸和氯吡格雷硫酸氢盐的单位剂型形药物组合物 Pending CN1359294A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9905497A FR2792836B3 (fr) 1999-04-30 1999-04-30 Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
FR99/05497 1999-04-30

Publications (1)

Publication Number Publication Date
CN1359294A true CN1359294A (zh) 2002-07-17

Family

ID=9545071

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00807001A Pending CN1359294A (zh) 1999-04-30 2000-04-25 含有乙酰水杨酸和氯吡格雷硫酸氢盐的单位剂型形药物组合物

Country Status (24)

Country Link
EP (1) EP1178809A1 (xx)
JP (1) JP2002543137A (xx)
KR (1) KR20020005735A (xx)
CN (1) CN1359294A (xx)
AR (1) AR023789A1 (xx)
AU (1) AU4303600A (xx)
BR (1) BR0010194A (xx)
CA (1) CA2371231A1 (xx)
CZ (1) CZ20013887A3 (xx)
EA (1) EA200100959A1 (xx)
EE (1) EE200100559A (xx)
FR (1) FR2792836B3 (xx)
HK (1) HK1041823A1 (xx)
HU (1) HUP0202329A2 (xx)
IL (1) IL145648A0 (xx)
IS (1) IS6084A (xx)
MX (1) MXPA01011071A (xx)
NO (1) NO20015295L (xx)
NZ (1) NZ514248A (xx)
PL (1) PL351923A1 (xx)
SK (1) SK15542001A3 (xx)
TR (1) TR200103039T2 (xx)
UY (1) UY26131A1 (xx)
WO (1) WO2000066130A1 (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104434932A (zh) * 2014-12-18 2015-03-25 成都苑东药业有限公司 一种硫酸氢氯吡格雷阿司匹林片药物组合物及其制备方法
CN105407877A (zh) * 2013-08-02 2016-03-16 赛诺菲 包含乙酰水杨酸和氯吡格雷的药物片剂
CN115737578A (zh) * 2022-11-23 2023-03-07 石家庄四药有限公司 一种硫酸氢氯吡格雷阿司匹林复方片及其制备方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287972B6 (sk) 2000-12-25 2012-08-06 Daiichi Sankyo Company Limited Pharmaceutical composition comprising 2-acetoxypyridine derivative and aspirin, kit comprising these compounds and use thereof
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
JP4917255B2 (ja) * 2003-10-16 2012-04-18 第一三共ヘルスケア株式会社 サリチル酸類含有経口組成物
WO2005070464A2 (en) * 2004-01-21 2005-08-04 Biofarma Ilac Sanayi Ve Ticaret A.S. A tablet formulation of clopidogrel bisulphate
EP1898911A1 (en) * 2005-06-13 2008-03-19 Elan Pharma International Limited Nanoparticulate clopidogrel and aspirin combination formulations
KR20070009851A (ko) * 2005-07-14 2007-01-19 씨제이 주식회사 클로피도그렐 황산수소염 함유 약학 조성물
WO2007035028A1 (en) * 2005-09-21 2007-03-29 Chong Kun Dang Pharmaceutical Corp. Novel resinate complex of s-clopidogrel and production method thereof
KR20070044323A (ko) * 2005-10-24 2007-04-27 에스케이케미칼주식회사 보관안정성이 개선된 클로피도그렐 황산수소염 함유 경구용제제
EP2001449A2 (en) * 2006-04-05 2008-12-17 Cadila Healthcare Ltd. Modified release clopidogrel formulation
EP1900358A1 (en) * 2006-09-16 2008-03-19 Cimex Pharma AG Pharmaceutical formulations comprising clopidogrel
HUP0600839A3 (en) * 2006-11-14 2008-09-29 Egis Gyogyszergyar Nyrt Solid pharmaceutical composition containing polymorph i of clopidogrel hydrogensulfate and process for the preparation thereof
US20110038931A1 (en) * 2008-02-22 2011-02-17 Hanall Biopharma Co., Ltd. Composite preparation
CN101695496A (zh) * 2009-10-15 2010-04-21 苏春华 一种含有三氟柳和氯吡格雷的药物组合物
JP2013032289A (ja) * 2009-10-28 2013-02-14 Daiichi Sankyo Co Ltd ワックス安定製剤
RU2484820C2 (ru) * 2011-02-24 2013-06-20 Общество с ограниченной ответственностью "Озон" Комбинированное лекарственное средство, являющееся ингибитором агрегации тромбоцитов
KR101675501B1 (ko) 2011-11-02 2016-11-14 한국유나이티드제약 주식회사 클로피도그렐 및 아스피린의 복합제제
CN102406938A (zh) * 2011-11-29 2012-04-11 北京阜康仁生物制药科技有限公司 一种抗血栓的药物组合物
JP6004524B2 (ja) * 2012-07-11 2016-10-12 大原薬品工業株式会社 クロピドグレル硫酸塩含有錠剤の製造方法
WO2017037741A1 (en) * 2015-09-02 2017-03-09 Sun Pharmaceutical Industries Ltd Compact solid dosage form of aspirin and clopidogrel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
US5576328A (en) * 1994-01-31 1996-11-19 Elf Sanofi Method for the secondary prevention of ischemic events
FR2744918B1 (fr) 1996-02-19 1998-05-07 Sanofi Sa Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105407877A (zh) * 2013-08-02 2016-03-16 赛诺菲 包含乙酰水杨酸和氯吡格雷的药物片剂
CN105407877B (zh) * 2013-08-02 2019-05-07 赛诺菲 包含乙酰水杨酸和氯吡格雷的药物片剂
CN104434932A (zh) * 2014-12-18 2015-03-25 成都苑东药业有限公司 一种硫酸氢氯吡格雷阿司匹林片药物组合物及其制备方法
CN104434932B (zh) * 2014-12-18 2017-05-24 成都苑东生物制药股份有限公司 一种硫酸氢氯吡格雷阿司匹林片药物组合物及其制备方法
CN115737578A (zh) * 2022-11-23 2023-03-07 石家庄四药有限公司 一种硫酸氢氯吡格雷阿司匹林复方片及其制备方法

Also Published As

Publication number Publication date
FR2792836B3 (fr) 2001-07-27
MXPA01011071A (es) 2002-07-22
AU4303600A (en) 2000-11-17
IS6084A (is) 2001-09-25
FR2792836A1 (fr) 2000-11-03
HUP0202329A2 (en) 2002-10-28
EP1178809A1 (fr) 2002-02-13
EA200100959A1 (ru) 2002-06-27
SK15542001A3 (sk) 2002-02-05
HK1041823A1 (zh) 2002-07-26
KR20020005735A (ko) 2002-01-17
NO20015295D0 (no) 2001-10-29
WO2000066130A1 (fr) 2000-11-09
PL351923A1 (en) 2003-06-30
IL145648A0 (en) 2002-06-30
NZ514248A (en) 2003-06-30
CA2371231A1 (en) 2000-11-09
EE200100559A (et) 2003-02-17
CZ20013887A3 (cs) 2002-02-13
UY26131A1 (es) 2000-12-29
TR200103039T2 (tr) 2002-01-21
AR023789A1 (es) 2002-09-04
BR0010194A (pt) 2002-02-13
NO20015295L (no) 2001-12-21
JP2002543137A (ja) 2002-12-17

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