CN1351602A - 新型药物活性化合物 - Google Patents

新型药物活性化合物 Download PDF

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Publication number
CN1351602A
CN1351602A CN00807844A CN00807844A CN1351602A CN 1351602 A CN1351602 A CN 1351602A CN 00807844 A CN00807844 A CN 00807844A CN 00807844 A CN00807844 A CN 00807844A CN 1351602 A CN1351602 A CN 1351602A
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CN
China
Prior art keywords
alkyl
compound
fluoro
methyl
indol
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Pending
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CN00807844A
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English (en)
Chinese (zh)
Inventor
K·卡拉贝拉斯
M·莱皮斯特
P·舍
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AstraZeneca AB
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AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901854A external-priority patent/SE9901854D0/xx
Priority claimed from SE0000645A external-priority patent/SE0000645D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1351602A publication Critical patent/CN1351602A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
CN00807844A 1999-05-21 2000-05-19 新型药物活性化合物 Pending CN1351602A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9901854-1 1999-05-21
SE9901854A SE9901854D0 (sv) 1999-05-21 1999-05-21 New pharmaceutically active compounds
SE0000645A SE0000645D0 (sv) 2000-02-28 2000-02-28 New pharmaceutically active compounds
SE0000645-2 2000-02-28

Publications (1)

Publication Number Publication Date
CN1351602A true CN1351602A (zh) 2002-05-29

Family

ID=26655003

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00807844A Pending CN1351602A (zh) 1999-05-21 2000-05-19 新型药物活性化合物

Country Status (16)

Country Link
US (1) US6492406B1 (OSRAM)
EP (1) EP1183252B1 (OSRAM)
JP (1) JP4796698B2 (OSRAM)
KR (1) KR20010113829A (OSRAM)
CN (1) CN1351602A (OSRAM)
AR (1) AR024060A1 (OSRAM)
AT (1) ATE259798T1 (OSRAM)
AU (1) AU4968600A (OSRAM)
BR (1) BR0010520A (OSRAM)
CA (1) CA2372743A1 (OSRAM)
DE (1) DE60008372T2 (OSRAM)
IL (1) IL146117A0 (OSRAM)
MX (1) MXPA01011884A (OSRAM)
NO (1) NO20015664L (OSRAM)
NZ (1) NZ515281A (OSRAM)
WO (1) WO2000071537A1 (OSRAM)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN107235966A (zh) * 2017-05-04 2017-10-10 浙江工业大学 一类3,4‑双吲哚‑1,2,4‑三氮唑酮类化合物及其制备方法和应用
CN116199687A (zh) * 2023-03-10 2023-06-02 石河子大学 一种β-咔啉-3位连接1,2,3-三氮唑类化合物及其制备方法、应用
CN116462623A (zh) * 2023-03-30 2023-07-21 南京神奇科技开发有限公司 一种吲哚-5-甲酸甲酯的制备方法

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AR045595A1 (es) * 2003-09-04 2005-11-02 Vertex Pharma Composiciones utiles como inhibidores de proteinas quinasas
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GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
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SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
CN101072759B (zh) * 2004-11-18 2013-06-19 Synta医药公司 调节hsp90活性的三唑化合物
WO2006117657A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Triazolone derivatives as anti-inflammatory agents
CA2618628C (en) * 2005-08-18 2014-11-18 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
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US8318790B2 (en) * 2006-05-25 2012-11-27 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
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WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
HUE025137T2 (en) 2007-08-21 2016-01-28 Senomyx Inc Compositions are bitter taste blocking (blocking) compounds
US8076491B2 (en) 2007-08-21 2011-12-13 Senomyx, Inc. Compounds that inhibit (block) bitter taste in composition and use thereof
EA022924B1 (ru) 2009-04-03 2016-03-31 Ф.Хоффманн-Ля Рош Аг ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ
MA33975B1 (fr) 2009-11-06 2013-02-01 Plexxikon Inc Composés et méthodes de modulation des kinases et leurs indications d'emploi
FR2953837B1 (fr) * 2009-12-10 2012-03-09 Sanofi Aventis Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
JP5941069B2 (ja) 2011-02-07 2016-06-29 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼ調節のための化合物および方法、ならびにそれに対する適応症
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
JP2014532712A (ja) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法
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CN107235966A (zh) * 2017-05-04 2017-10-10 浙江工业大学 一类3,4‑双吲哚‑1,2,4‑三氮唑酮类化合物及其制备方法和应用
CN107235966B (zh) * 2017-05-04 2019-12-03 浙江工业大学 一类3,4-双吲哚-1,2,4-三氮唑酮类化合物及其制备方法和应用
CN116199687A (zh) * 2023-03-10 2023-06-02 石河子大学 一种β-咔啉-3位连接1,2,3-三氮唑类化合物及其制备方法、应用
CN116199687B (zh) * 2023-03-10 2024-04-19 石河子大学 一种β-咔啉-3位连接1,2,3-三氮唑类化合物及其制备方法、应用
CN116462623A (zh) * 2023-03-30 2023-07-21 南京神奇科技开发有限公司 一种吲哚-5-甲酸甲酯的制备方法

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DE60008372T2 (de) 2005-05-19
CA2372743A1 (en) 2000-11-30
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US6492406B1 (en) 2002-12-10
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AU4968600A (en) 2000-12-12

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