CN1348717A - Diatotherapeutic flour for treating diabetes and its production process - Google Patents

Diatotherapeutic flour for treating diabetes and its production process Download PDF

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Publication number
CN1348717A
CN1348717A CN01114927A CN01114927A CN1348717A CN 1348717 A CN1348717 A CN 1348717A CN 01114927 A CN01114927 A CN 01114927A CN 01114927 A CN01114927 A CN 01114927A CN 1348717 A CN1348717 A CN 1348717A
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herba
flour
diatotherapeutic
dry
semen
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陈杰
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YONG'AN COUNTRY GOVERNMENT SHIZHONG DISTRICT ZAOSHUANG
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YONG'AN COUNTRY GOVERNMENT SHIZHONG DISTRICT ZAOSHUANG
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Abstract

The present invention relates to dietary flour for diabetes and its preparing method. It is made from 18 kinds of raw material including dried hawthorn, pussley, dandelion, corn sligma, carrot, gingo leaf, gynostemma pentaphylla, celexy, astragalus root, safflower, licorice, dry ginger, sorghum, soybean, standard wheat flour, peanut kernel, blade rich and others. The invented product possesses the functions of regulating human body sugar metabolism, raising sugar tolerance, promoting regeneration of insulin cell, improving blood circulation, lowering blood viscosity etc.

Description

Diatotherapeutic flour of treatment diabetes and preparation method thereof
The present invention relates to a kind of Diatotherapeutic flour that is used for diabetics and preparation method thereof.
In the technology, Buckwheat flour is diabetes patient's a first-selected food at present, though sugar content is lower, nutrition, taste are all relatively poor, and bad to the glycometabolic regulating effect of human body.Other has denomination of invention to be: the flour and the preparation method (patent No.: 94110644.6 of manufacturing diabetics food; Authorization notification number: 1040171; The patentee: patent of invention Yang Bo), its raw material are Poria, Fructus Mori, Semen phaseoli radiati, Semen Euryales, Rhizoma Dioscoreae, Semen Ormosiae Hosiei, Fructus Crataegi, Semen Coicis, Oryza glutinosa, Folium Mori, Semen Nelumbinis, corn, Fructus Lycii, Semen Tritici aestivi, Arillus Longan and beans.Above raw material just obtains the diabetics Diatotherapeutic flour that this contains Chinese medicinal ingredients after operations such as decoction, filtration, drying are handled.This flour is regulated carbohydrate metabolism, improves anti-sugar amount and is stimulated the release of insulin system, and certain curative effect is arranged, but it be primarily aimed in, patients with mild, the severe patient is not had effect basically.Relatively poor for Diabetes with Hypertension, hyperlipidemia and cardiovascular and cerebrovascular disease curative effect.
The purpose of this invention is to provide that a kind of effective adjusting carbohydrate metabolism stimulates insulin secretion, blood pressure lowering, blood fat reducing, control cordis and cerebral accident, be suitable for the flour of patients with diabetes mellitus.
Another object of the present invention provides a kind of preparation method for preparing the Diatotherapeutic flour for the treatment of diabetes.
The Diatotherapeutic flour of treatment diabetes of the present invention is made (weight portion) by following raw materials according:
Fructus Crataegi dry slice 0.05~0.1 Herba Portulacae 0.08~0.15
Herba Taraxaci 0.08~0.15 Stigma Maydis 0.03~0.06
Hu Luobu 0.08~0.16 Folium Ginkgo 0.12~0.18
So strand is blue 0.08~0.16 Herba Apii graveolentis 0.07~0.15
Herba Capsellae 0.05~0.1 Radix Astragali 0.02~0.08
Flos Carthami 0.01~0.03 Radix Glycyrrhizae 0.01~0.03
Rhizoma Zingiberis 0.01~0.03 Sorghum vulgare Pers. 0.12~0.18
Standard flour 0.7~0.8 Semen sojae atricolor 0.12~0.18
Semen arachidis hypogaeae 0.05~0.1 fructus zizaniae caduciflorae 0.2~0.3
The method of Diatotherapeutic flour that is used to prepare these treatment diabetes is as follows:
The Radix Astragali in the above-mentioned raw materials, Radix Glycyrrhizae, Flos Carthami, strand so indigo plant takes by weighing by weight, are added 670 degree hot water 2500ml and soaked one hour, decoct half an hour then, taking liquid is condensed into paste after filtering, dry for standby.
Herba Portulacae, Herba Taraxaci, Stigma Maydis, Folium Ginkgo, Herba Capsellae in the raw material are taken by weighing by weight, remove impurity and clean, put into boiling water and scalded 5 minutes, take out and dry or dry.
Hu Luobu, Herba Apii graveolentis, clean decontamination cutting in the above-mentioned raw materials are dried or dried.
Above-mentioned three step gained are mixed, add Fructus Crataegi dry slice, the dried stir-fry of Rhizoma Zingiberis 5 minutes, afterwards that its pulverizing is standby.
Sorghum vulgare Pers., Semen sojae atricolor, fructus zizaniae caduciflorae, Semen arachidis hypogaeae decontamination are sieved, afterwards that its pulverizing is standby.
Different fine powder that pulverizing is standby and standard flour mixing and stirring.
The property of medicine of grain, medicine food dual purpose plant, crude drug and pharmacological effect thereof in the raw material:
Grain refers to Semen sojae atricolor, Sorghum vulgare Pers., standard flour, Semen arachidis hypogaeae, fructus zizaniae caduciflorae.Medicine food dual purpose plant refers to Herba Portulacae, Folium Ginkgo, Fructus Crataegi dry slice, Stigma Maydis, Hu Luobu, Herba Apii graveolentis, Herba Capsellae, in Rhizoma Zingiberis Recens, Herba Taraxaci.Crude drug refers to that so the Radix Astragali, Radix Glycyrrhizae, Flos Carthami, strand are blue.
Sorghum vulgare Pers., fructus zizaniae caduciflorae: sweet in the mouth is warm in nature, contain multivitamin, mineral, phytoprotein etc. blood fat reducing and spleen invigorating kidney YIN nourishing and QI supplementing blood function.
Standard flour: abundant sugar, vegetable protein, mineral are put down, contained to sweet in the mouth, human body must aminoacid.Effect: invigorating the spleen and regulating the stomach, benefit earth culture unit, additional body energy.
Semen sojae atricolor, Semen arachidis hypogaeae: sweet in the mouth, oryzanol and ferulic acid mixture, the Semen Glycines enzyme of containing warm in nature.Effect: the stasis of blood clearly of promoting the production of body fluid, the spleen invigorating alleviating distention in middle-JIAO has the blood fat reducing blood sugar lowering to promote islet cell function to recover.
Fructus Crataegi: sour in the mouth is sweet, and is warm in nature, contains bad hematic acid, bioactive substance, and dyspepsia and intestinal stasis relieving is arranged, the clots absorbing that promotes the production of body fluid, blood pressure lowering, effect for reducing blood fat.
Herba Apii graveolentis: sweet in the mouth is cool in nature, contains to enrich plant cellulose, biological activity element, and the spleen invigorating intestinal stasis relieving is arranged, liver heat removing and eyesight improving, blood pressure lowering, blood fat reducing, hypoglycemic activity.
So Folium Ginkgo, strand are blue: mildly bitter flavor, and cool in nature, contain flavonoid glycoside, blood pressure lowering, blood fat reducing, coronary artery dilating are arranged, improve cardiac-cerebral ischemia, blood circulation promoting and blood stasis dispelling, the merit of regulating QI to relieve pain.
The Radix Astragali: sweet in the mouth, warm in nature, contain astragalin and alkaloid, blood pressure lowering, blood fat reducing, blood viscosity lowering are arranged, improve coronary blood supply, enhancing human body immunity power, Yiqiyangyuan, the holder just uncharm, nourish heart and promote blood circulation, the usefulness of invigorating spleen to remove dampness.
Flos Carthami: acrid in the mouth, little hardship, warm in nature, contain Flos Carthami ketone, blood pressure lowering is arranged, the blood fat reducing coronary artery dilating, reduce the sticking viscosity of blood, promoting blood circulation to remove obstruction in the collateral, blood-activating analgetic.
Herba Capsellae: sweet in the mouth, cool in nature, contain the vegetable protein biotin, blood pressure lowering, blood fat reducing, blood sugar lowering are arranged, liver heat removing and eyesight improving, the usefulness of tonifying speen and tonifying kidney.
Hu Luobu: sweet in the mouth is flat, contains carotin, vegetable protein, blood fat reducing is arranged, enhancing human body immunity power, the effect of invigorating the spleen and regulating the stomach benefiting vital QI and blood.
Herba Portulacae: sweet in the mouth is flat, contains plant cellulose, vegetable protein, and blood fat reducing, blood sugar lowering, heat-clearing and toxic substances removing, strong board dampness removing effect are arranged.
Rhizoma Zingiberis: acrid in the mouth, warm in nature, contain (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, blood fat reducing, blood pressure lowering arranged, prevent thrombosis, anti-myocardial infarction has special efficacy, lasting stability, blood circulation promoting and blood stasis dispelling, spleen invigorating is fallen wet.
Radix Glycyrrhizae: sweet in the mouth, cool in nature, contain licoricon, blood fat reducing, blood pressure lowering are arranged, coordinating the actions of various ingredients in a prescription, antipyretic and antidote functions.
The Diatotherapeutic flour of this treatment diabetes can be used for making food such as battercake that the patient takes for a long time, noodles, instant noodles, cookies, it can effectively be regulated the human body saccharifying and thank, improve carbohydrate tolerance, promote insulin cell regeneration and restore funcitons, improve blood circulation, blood viscosity lowering, prevent that cordis and cerebral accident from taking place, to heavy type ii diabetes bound drug treatment, fairly obvious effect is arranged, and cost is lower.
The clinical comparison experiment divides two groups to carry out at the type ii diabetes people.Wherein 116 people are organized in treatment, type ii diabetes accompanied with hypertension, hyperlipidemia man 50 people, women 66 people, 59.8 ± 8.6 years old mean age, average course of disease 9.6 ± 5.8 years.Matched group 118 people, type ii diabetes accompanied with hypertension, hyperlipidemia, wherein male 56 people, women 62 people, 59.7 ± 8.5 years old mean age, average course of disease 9.5 ± 5.9 years.Two groups of ages, the course of disease, blood glucose, blood pressure, blood fat P>0.05.It is metformin or diabetes pill, captopril supporting treatment that the treatment group adopts conventional therapy, adds food Chinese medicine dietetic therapy of the present invention, and dietetic therapy is breakfast 100g, Chinese meal 200g, and dinner 100g, 2 weeks were a course of treatment.Matched group adopts conventional therapy to add common dietetic therapy.Clinical observation inkstone order comprises:
Blood glucose: BS and 2hBS on an empty stomach after the meal.
Blood pressure: press the WHO regulation, survey seat right arm brachial arterial pressure, METHOD FOR CONTINUOUS DETERMINATION is averaged for three times, and does record and fill out card.
Blood fat (on an empty stomach): cholesterol (TC), triacylglycerol (TG).
Complication: angina pectoris attacks number of times (inferior/week), the increase and decrease of conventional therapy medicine, Chinese medicine dietetic therapy toxic and side effects, a situation arises for the heart, cerebrovascular accident.
Efficacy determination:
Produce effects: empty stomach BS decline 〉=3.0mmol/L; 2hBS decline 〉=3.5mmol/L after the meal; TC decline 〉=1.5mmol/L; TC decline 〉=1.0mmol/L; blood pressure DBP decline 1.33kpa; SBP drops to normal or decline 3.99kpa, and angina pectoris attacks reduces by 〉=3 times/week, and conventional medicine subtracts original vol 〉=50%.
Effectively: BS decline 〉=2.0mmol/L on an empty stomach, 2hBS decline 〉=2.5mmol/L after the meal, TC decline 〉=1.0mmol/L, TC decline 〉=0.6mmol/L, the blood pressure DBP 1.33~2.66kpa that descends, SBP decline 2.66kpa, angina pectoris attacks reduces by 〉=2 times/week, and conventional medicine reduces original vol 〉=25%.
Relatively, two all produce effects P<0.05 are organized in treatment before and after two groups of treatments, and there were significant differences, and there is highly significant difference 4 week back produce effects P<0.01.One routine myocardial infarction and cerebrovascular accident do not take place in March in treatment group 116 examples.Myocardial infarction 22 examples take place in matched group 118 examples in March, cerebrovascular accident 14 examples have significant difference.
Below in conjunction with embodiment in detail the present invention is described in detail.
Embodiment 1:
The raw material material proportioning of the Diatotherapeutic flour of treatment diabetes is:
Fructus Crataegi dry slice 0.1kg, Herba Portulacae 0.15kg, Herba Taraxaci 0.15kg, Stigma Maydis 0.06kg, Hu sieve are foretold 0.16kg, Semen Ginkgo 0.18kg, strand event blue 0.16kg, Herba Apii graveolentis 0.15kg, Herba Capsellae 0.1kg, Radix Astragali 0.05kg, Flos Carthami 0.03kg, Radix Glycyrrhizae 0.03kg, Rhizoma Zingiberis 0.03kg, Sorghum vulgare Pers. 0.18kg, standard flour 0.8kg, Semen sojae atricolor 0.18kg, Semen arachidis hypogaeae 0.1kg, fructus zizaniae caduciflorae 0.3kg.Make its crude drug of flour material and account for raw material total amount 2.8%, medicine food dual purpose plant accounts for total amount 9.6%, and the grain class accounts for total amount 87.6%.
The crude drug composition refers to the Radix Astragali, Flos Carthami, blue, the Radix Glycyrrhizae of strand event, and medicine food dual purpose plant refers to: Herba Portulacae, Herba Taraxaci, Herba Apii graveolentis, Radix Dauci Sativae, Fructus Crataegi dry slice, Stigma Maydis, Folium Ginkgo, Herba Capsellae, Rhizoma Zingiberis.The grain class refers to: Sorghum vulgare Pers., Semen sojae atricolor, Semen arachidis hypogaeae, fructus zizaniae caduciflorae, standard flour.
Preparation characteristic Diatotherapeutic flour preparation method:
1. the above-mentioned raw materials Radix Astragali, Flos Carthami, strand are spent hot water 2500ml so indigo plant adds 60~70, soaked one hour, decoct then and boil half an hour, taking liquid is condensed into paste after filtering, dry for standby.
2. above-mentioned raw materials Herba Portulacae, Herba Taraxaci, Stigma Maydis Folium Ginkgo, Herba Capsellae are cleaned decontamination and put into boiling water boiling hot 5 minutes, take out and dry or dry.
3. with above-mentioned Radix Dauci Sativae, the Herba Apii graveolentis elder generation flush away impurity section of chopping up, dry or dry.
4. will be 1. 2. 3. mix and add Fructus Crataegi dry slice, Rhizoma Zingiberis slow fire is done and was fried 5 minutes, pulverizer is ground into fine powder.
5. with Sorghum vulgare Pers., fructus zizaniae caduciflorae, Semen arachidis hypogaeae, Semen sojae atricolor decontamination, slow fire was fried 5 minutes, and pulverizer is ground into fine powder.
6. with standard flour with 4. 5. go on foot gained fine powder mixing and stirring and be flour of the present invention.
Utilize this flour can produce long its edible various food of suitable patient such as noodles, instant noodles, battercake, cookies etc.Noodles are produced by the noodles production technology, this kind noodles bitter in the mouth, and mouthfeel is good, and instant noodles are pressed process of preparing instant noodles production, and the appropriate to the occasion proper amount of edible vegetable oil of processing such as cookies, bread increases food mouthfeel and impression.
Embodiment 2
Make the proportioning raw materials of the Diatotherapeutic flour of treatment diabetes:
So Fructus Crataegi dry slice 0.05kg Herba Portulacae 0.08kg Herba Taraxaci 0.08kg Stigma Maydis 0.03kg Radix Dauci Sativae 0.08kg Folium Ginkgo 0.12kg strand is blue 0.08kg Herba Apii graveolentis 0.07kg Herba Capsellae 0.05kg Radix Astragali 0.02kg Flos Carthami 0.1kg Radix Glycyrrhizae 0.01kg Rhizoma Zingiberis 0.01kg Sorghum vulgare Pers. 0.12kg standard flour 0.7kg Semen sojae atricolor 0.12kg Semen arachidis hypogaeae 0.05kg fructus zizaniae caduciflorae 0.2kg
The flour material of making this food is the crude drug composition wherein: the Radix Astragali, Radix Glycyrrhizae, Flos Carthami, strand are so indigo plant accounts for raw material total amount 1.2%, medicine food dual purpose plant Herba Portulacae, Folium Ginkgo Stigma Maydis, Herba Taraxaci, Radix Dauci Sativae, Herba Apii graveolentis, Herba Capsellae, Rhizoma Zingiberis, Fructus Crataegi dry slice account for the total material 6.2% of raw material, and grain class composition: Semen sojae atricolor, Sorghum vulgare Pers., standard flour, Semen arachidis hypogaeae, fructus zizaniae caduciflorae account for raw material total amount 92.6%.
The method for preparing this flour is with embodiment 1.
Embodiment 3
Make the optimum proportion of materials of the Diatotherapeutic flour of treatment diabetes:
So Fructus Crataegi dry slice 0.1kg Herba Portulacae 0.12kg Herba Taraxaci 0.12kg Stigma Maydis 0.04kg Radix Dauci Sativae 0.12kg Folium Ginkgo 0.15kg strand is blue 0.12kg Herba Apii graveolentis 0.12kg Herba Capsellae 0.08kg Radix Astragali 0.03kg Flos Carthami 0.02kg Radix Glycyrrhizae 0.02kg Rhizoma Zingiberis 0.02kg Sorghum vulgare Pers. 0.16kg standard flour 0.75kg Semen sojae atricolor 0.16kg Semen arachidis hypogaeae 0.08kg fructus zizaniae caduciflorae 0.25kg
The flour material of making this food is the crude drug composition wherein: the Radix Astragali, Radix Glycyrrhizae, strand are so blue, Flos Carthami accounts for gross weight (raw material) 1.8%, medicine food dual purpose plant: Herba Portulacae, Folium Ginkgo, Fructus Crataegi dry slice, Stigma Maydis, Radix Dauci Sativae, Herba Apii graveolentis, Herba Capsellae, Rhizoma Zingiberis, Herba Taraxaci account for gross weight 9.6%, and grain class composition: Semen sojae atricolor, Sorghum vulgare Pers., standard flour, Semen arachidis hypogaeae, fructus zizaniae caduciflorae account for 88.6%.
The method for preparing this flour is with embodiment 1.

Claims (3)

1, a kind of Diatotherapeutic flour for the treatment of diabetes, its proportioning raw materials (weight portion) is:
Fructus Crataegi dry slice 0.05~0.1 Herba Portulacae 0.08~0.15
Herba Taraxaci 0.08~0.15 Stigma Maydis 0.03~0.06
Hu Luobu 0.08~0.16 Folium Ginkgo 0.12~0.18
So strand is blue 0.08~0.16 Herba Apii graveolentis 0.07~0.15
Herba Capsellae 0.05~0.1 Radix Astragali 0.02~0.08
Flos Carthami 0.01~0.03 Radix Glycyrrhizae 0.01~0.03
Rhizoma Zingiberis 0.01~0.03 Sorghum vulgare Pers. 0.12~0.18
Standard flour 0.7~0.8 Semen sojae atricolor 0.12~0.18
Semen arachidis hypogaeae 0.05~0.1 fructus zizaniae caduciflorae 0.2~0.3.
2, the Diatotherapeutic flour of treatment diabetes as claimed in claim 1, its raw material optimum ratio (weight portion) is:
Fructus Crataegi dry slice 0.1 Herba Portulacae 0.12 Herba Taraxaci 0.12
Stigma Maydis 0.04 Radix Dauci Sativae 0.12 Folium Ginkgo 0.15
So strand is blue 0.12 Herba Apii graveolentis, 0.12 Herba Capsellae 0.08
The Radix Astragali 0.03 Flos Carthami 0.02 Radix Glycyrrhizae 0.02
In Rhizoma Zingiberis Recens 0.02 Sorghum vulgare Pers. 0.16 standard flour 0.75
Semen sojae atricolor 0.16 Semen arachidis hypogaeae 0.08 fructus zizaniae caduciflorae 0.25.
3, a kind of method for preparing the Diatotherapeutic flour of the described treatment diabetes of claim 1, it is made of following steps:
The Radix Astragali in the raw material in the claim 1, Radix Glycyrrhizae, Flos Carthami, strand so indigo plant takes by weighing by weight, are added 60~70 degree hot water 2500ml and soaked one hour, decoct half an hour then, taking liquid is condensed into paste after filtering, dry for standby;
Herba Portulacae, Herba Taraxaci, Stigma Maydis, Folium Ginkgo, Herba Capsellae in the raw material are taken by weighing by weight, remove impurity and clean, put into boiling water and scalded 5 minutes, take out and dry or dry:
Hu Luobu, Herba Apii graveolentis in the above-mentioned raw materials are cleaned the decontamination cutting to be dried or dries;
Above-mentioned three step gained are mixed, add Fructus Crataegi dry slice, the dried stir-fry of Rhizoma Zingiberis 5 minutes, afterwards that its pulverizing is standby;
Sorghum vulgare Pers., Semen sojae atricolor, fructus zizaniae caduciflorae, Semen arachidis hypogaeae decontamination are sieved, afterwards that its pulverizing is standby;
Different fine powder that pulverizing is standby and standard flour mixing and stirring.
CN01114927A 2001-05-10 2001-05-10 Diatotherapeutic flour for treating diabetes and its production process Pending CN1348717A (en)

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CN101878790A (en) * 2010-06-30 2010-11-10 安徽省东方糖尿病防治研究所 Nutrification flour for diabetics and preparation method thereof
CN102125218A (en) * 2011-01-24 2011-07-20 刘鹏 Health-care noodles and preparation method thereof
CN103039553A (en) * 2012-12-20 2013-04-17 苏州天南星生物科技有限公司 Application of purslane in flour
CN103229797A (en) * 2013-03-29 2013-08-07 薛朝贵 Gynostemma pentaphylla depressurizing health care biscuit and preparation method thereof
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CN101878790B (en) * 2010-06-30 2011-11-23 安徽省东方糖尿病防治研究所 Nutrification flour for diabetics and preparation method thereof
CN101878790A (en) * 2010-06-30 2010-11-10 安徽省东方糖尿病防治研究所 Nutrification flour for diabetics and preparation method thereof
CN102125218A (en) * 2011-01-24 2011-07-20 刘鹏 Health-care noodles and preparation method thereof
CN103039553A (en) * 2012-12-20 2013-04-17 苏州天南星生物科技有限公司 Application of purslane in flour
CN103229797A (en) * 2013-03-29 2013-08-07 薛朝贵 Gynostemma pentaphylla depressurizing health care biscuit and preparation method thereof
CN103229797B (en) * 2013-03-29 2015-04-08 薛朝贵 Gynostemma pentaphylla depressurizing health care biscuit and preparation method thereof
CN103461770A (en) * 2013-06-03 2013-12-25 安徽双鹿面粉有限公司 Gynostemma pentaphylla-containing flour making method
CN103385413A (en) * 2013-08-13 2013-11-13 青岛福加德面粉有限公司 Wheat compound flour and preparation method thereof
CN103392986A (en) * 2013-08-13 2013-11-20 青岛福加德面粉有限公司 Gerocomia wheat flour and preparation method thereof
CN103385413B (en) * 2013-08-13 2014-05-07 青岛福加德面粉有限公司 Wheat compound flour and preparation method thereof
CN103445063B (en) * 2013-08-18 2014-09-03 青岛福加德面粉有限公司 Health-care flour applicable to patients with hyperglycemia to eat
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CN104187361A (en) * 2014-07-04 2014-12-10 叶海峰 Health-care noodle capable of regulating blood sugar and preparation method thereof
CN104621469A (en) * 2015-01-14 2015-05-20 魏永义 Food with function of reducing blood pressure
CN106578918A (en) * 2016-03-13 2017-04-26 青岛嘉瑞生物技术有限公司 Selenium-enriched suaeda salsa nutritional health-care fine dried noodles and production technology thereof
CN107692027A (en) * 2017-11-30 2018-02-16 黄桂月 A kind of Madeira-vine noodle and preparation method thereof
CN108112655A (en) * 2017-12-29 2018-06-05 常盛杰 A kind of wheat flour full of nutrition
CN109645313A (en) * 2018-12-17 2019-04-19 淮北市金华面粉有限公司 A kind of tonifying Qi stomach-nourishing type whole wheat and preparation method thereof with traditional Chinese medicine ingredients
CN113383898A (en) * 2021-06-25 2021-09-14 汉中青鑫宝缘特种食品有限公司 Noodles with adjuvant curative effect on hypertension, hyperglycemia and hyperlipidemia, cardiovascular and cerebrovascular diseases and coronary heart disease

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