CN114470103A - Medicinal and edible composition for reducing blood sugar and preparation method and application thereof - Google Patents

Medicinal and edible composition for reducing blood sugar and preparation method and application thereof Download PDF

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CN114470103A
CN114470103A CN202210076507.XA CN202210076507A CN114470103A CN 114470103 A CN114470103 A CN 114470103A CN 202210076507 A CN202210076507 A CN 202210076507A CN 114470103 A CN114470103 A CN 114470103A
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parts
medicine
medicinal
barrel
blood sugar
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方彦雯
方志财
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Heye Health Technology Co Ltd
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Heye Health Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K2236/30—Extraction of the material
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention belongs to the technical field of traditional Chinese medicine granules, and particularly relates to a food-medicine homologous composition for reducing blood sugar and a preparation method thereof. The medicinal and edible composition comprises the following raw materials of effective components in parts by weight: 10-25 parts of resistant starch, 10-25 parts of poria cocos, 5-15 parts of wolfberry, 2-8 parts of dendrobium leaves, 3-9 parts of honey-fried licorice roots, 2-4 parts of gypsum and 0.5-1.5 parts of ginseng; the medicinal and edible formula granules obtained by the decoction method have the effects of preventing the rapid rise or the rapid fall of blood sugar and stabilizing the blood sugar. The preparation method is simple, and can bring effective components of the traditional Chinese medicines into full play and bring out the best in each other.

Description

Medicinal and edible composition for reducing blood sugar and preparation method and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine granules, and particularly relates to a food-medicine homologous composition for reducing blood sugar and a preparation method thereof.
Background
Diabetes, a chronic metabolic disease characterized by hyperglycemia, is currently not completely cured. At present, the diabetes patients in China are in the first world and are in a hyperglycemia state for a long time, so that blood vessels of the patients are damaged, and the blood vessels are hardened, thereby inducing complications.
At present, the chemical drugs for reducing blood sugar include sulfonylurea drugs, biguanide hypoglycemic drugs, alpha glucosidase inhibitors, insulin sensitizers and the like, and all of the chemical drugs can cause certain side effects.
Diabetes is called as diabetes by traditional Chinese medicine. The pathogenesis of diabetes is mainly deficiency of body yin, weakness of five internal organs, improper diet, overeating, fat and sweet, emotional disorder, overstrain and the like. Based on western medicines, the traditional Chinese medicine is used for assisting in treating chronic diabetes, controlling the development of disease conditions, enhancing the body condition of patients, preventing various chronic complications and improving the life quality of the patients with diabetes.
The conventional treatment in the market comprises treatment by using related traditional Chinese medicines and western medicines, but has certain side effect on human bodies and is not suitable for being eaten as health-care food in daily life.
Disclosure of Invention
The invention aims to provide a medicine-food homologous composition for reducing blood sugar by combining pursuits of people on natural healthy food, aiming at the defects of hyperglycemia products on the current market, and promoting the balance of intestinal flora, reducing blood fat, regulating and controlling blood sugar concentration.
The invention relates to a medicinal and edible composition for reducing blood sugar, which comprises the following raw materials of effective components in part by weight: 10-25 parts of resistant starch, 10-25 parts of poria cocos, 5-15 parts of wolfberry, 2-8 parts of dendrobium leaves, 3-9 parts of honey-fried licorice roots, 2-4 parts of gypsum and 0.5-1.5 parts of ginseng.
Compatibility means that two or more herbs are selectively combined according to the disease condition and property of the herbs. The compatibility and application of the medicines are the main forms of the traditional Chinese medicine. The Chinese herbal medicines are combined according to a certain law, a certain component proportion is determined, and different effective components of the Chinese herbal medicines are self-assembled into a supermolecular structure with a specific curative effect under the induction of weak bonds in the decocting process to prepare the prescription.
The traditional Chinese medicine composition has the following characteristics:
ginseng: mild, sweet, slightly bitter and slightly warm in nature and taste. It enters spleen and lung meridians. The efficacy is as follows: tonify primordial qi, tonify spleen and lung, promote the production of body fluid to quench thirst, soothe nerves and promote intelligence. The main treatment is as follows: impairment due to overstrain, anorexia, listlessness, regurgitation, diarrhea, cough, dyspnea, spontaneous perspiration, palpitation, amnesia, vertigo, headache, sexual impotence, frequent micturition, diabetes, metrorrhagia, infantile chronic convulsion, and deficiency syndrome.
Tuckahoe, poria cocos: sweet and bland in nature and taste, mild in nature. The efficacy is as follows: induce diuresis and drain dampness, invigorate spleen and soothe nerves. The main treatment is as follows: edema, dysuria, spleen deficiency, palpitation, insomnia.
Honey-fried licorice root: sweet in nature and taste and mild in nature. The efficacy is as follows: tonify qi, strengthen the middle energizer, clear away heat and toxic material, dispel phlegm, relieve cough, relieve spasm, alleviate pain, and harmonize property of the drugs. Invigorating spleen and regulating stomach function, and benefiting qi and lode.
Wolfberry fruit: sweet in nature and taste, mild and effective: nourishing liver and kidney, replenishing vital essence and improving eyesight.
And (3) dendrobium leaves: sweet in nature and taste, slightly cold. The efficacy is as follows: to nourish yin, clear heat, nourish stomach and promote fluid production. It is indicated for body fluids damaged by heat, low fever with polydipsia, red tongue with little coating; stomach deficiency, thirst, dry throat, vomiting, poor appetite, dull pain in the stomach, light tongue with little coating; kidney is deficient and the object is blurred.
Gypsum: sweet, pungent and cold in nature. The efficacy is as follows: clear heat and purge fire, relieve restlessness and quench thirst. Can be used for treating exogenous febrile disease. Cough and dyspnea due to lung heat, and hyperactivity of stomach fire.
Poria cocos and dendrobium have the efficacy of tonifying qi, removing heat, strengthening yin and replenishing vital essence, and are usually used for treating stomach yin deficiency, fever and body fluid injury, flaccidity of tendons and bones and other diseases.
Resistant starch, also known as resistant starch, which was proposed by Englyst et al in 1982, is not digested and absorbed in the human intestinal tract. Resistant starches are divided into four categories: RS1, RS2, RS3 and RS 4. Wherein RS3 refers to retrograded starch polymer, is formed by cooling gelatinized starch, and has the strongest enzymolysis resistance. There are 2 different explanations for the mechanism of resistance to enzymatic hydrolysis of RS 3: one is thought to be due to the formation of amylose crystals that prevent the amylase from approaching the glucosidic bonds of the crystalline regions and binding sites in the amylase active group to the starch molecule, thus imparting resistance to enzymatic hydrolysis by RS 3; another reason that RS3 is resistant to enzymatic hydrolysis is believed to be that RS3 has a very strong molecular structure and high thermal stability due to the strong hydrogen bonding and van der Waals forces between the double helices forming the amylose crystal, and thus is not digested and absorbed in the human gastrointestinal tract.
The resistant starch is used as a dietary fiber, has a low glycemic index, can reduce postprandial blood glucose level, and increases satiety.
Further, as a preferable embodiment, the health-care food comprises 10 parts of resistant starch, 25 parts of poria cocos, 5 parts of medlar, 8 parts of dendrobium nobile leaves, 3 parts of honey-fried licorice roots, 2 parts of gypsum and 0.5 part of ginseng.
Further, as a preferable embodiment, 15 parts of resistant starch, 15 parts of poria cocos, 10 parts of medlar, 5 parts of dendrobium leaves, 6 parts of honey-fried licorice roots, 3 parts of gypsum and 1 part of ginseng.
Further, as a preferred embodiment, 25 parts of resistant starch, 10 parts of poria cocos, 15 parts of medlar, 2 parts of dendrobium leaves, 9 parts of honey-fried licorice roots, 4 parts of gypsum and 1.5 parts of ginseng.
Further, as a preferred embodiment, the resistant starch is canna RS3 resistant starch. Canna RS3 resistant starch is preferably to type B structure, chain length DP37-100 ratio. The canna edulis ker resistant starch with the structure can obviously reduce dyslipidemia and improve the structural disorder of intestinal flora.
The canna RS3 resistant starch is prepared from canna plant. The health food prepared by taking canna RS3 resistant starch as a main raw material has the health-care function of inhibiting the rapid rise or decrease of blood sugar proved by animal function tests; promoting intestinal flora balance, reducing blood lipid, and regulating and controlling blood glucose concentration.
The invention also relates to a preparation method (original taste) of the medicinal and edible composition for reducing blood sugar, which comprises the following steps:
(1) mixing Poria, fructus Lycii, folium Dendrobii, radix Glycyrrhizae Preparata, and Gypsum Fibrosum, adding water 6-15 times of the raw materials, decocting at 80-100 deg.C for 50-90 min to obtain concentrated medicinal liquid A;
(2) stirring resistant starch and Ginseng radix powder to obtain powder B;
(3) and (3) mixing the concentrated liquid medicine A prepared in the step (1) with the powder B prepared in the step (2) at 40-60 ℃, and fully absorbing the concentrated liquid medicine A by the powder B to obtain a semi-solid material C.
The concentrated liquid medicine A is in a proper concentration proportion, and is kept at a certain temperature, so that the concentrated liquid medicine A is easily and uniformly mixed with the powder B to achieve better fusion, thereby not only facilitating the exertion of the drug effect, but also facilitating the processing treatment. The semi-solid material C obtained by the method can be directly eaten as a paste formula.
Further, as a preferred embodiment, the raw materials in the step (1) are decocted for two times, the decoction is combined to obtain a concentrated liquid medicine A, and the mass ratio of the concentrated liquid medicine A to the raw material liquid in the step (1) is 20-55%. The medicine is decocted for 2 times, so that the effective components in the traditional Chinese medicine can be fully released, and the traditional Chinese medicine components interact with each other to achieve the optimal medicine effect.
Preferably, the traditional Chinese medicine extraction device adopted for decoction and extraction comprises a medicine decoction barrel, a water layer flow mixing mechanism which is rotationally matched in the medicine decoction barrel, a supporting plate which is fixedly sleeved on the periphery of the water layer flow mixing mechanism, and medicine placing filter cylinders which are circumferentially arrayed on the supporting plate;
a stirring mechanism meshed with the inner wall of the medicine boiling barrel is rotationally matched in the medicine placing filter cylinder, and a driving mechanism in sliding connection with the water layer mixed flow mechanism is arranged on the upper side of the medicine boiling barrel;
the water layer flow mixing mechanism comprises a filter barrel which is rotationally matched in the medicine boiling barrel and is connected with the supporting plate and the driving mechanism, and a spiral stirring shaft which is fixedly arranged in the filter barrel and is fixed on the inner wall of the medicine boiling barrel;
the stirring mechanism comprises a stirring component which is rotationally matched in the medicine placing filter cylinder, a connecting plate which is arranged on the medicine placing filter cylinder, a first gear which is rotationally matched on the connecting plate and is meshed with the stirring component and the inner wall of the medicine boiling barrel, and a plurality of tooth grooves which are circumferentially arrayed on the inner wall of the medicine boiling barrel;
the driving mechanism comprises a cover ring arranged on the medicine boiling barrel and a driving motor arranged at the center of the cover ring, a polygonal hole is formed in the upper side of the filtering barrel, and an output shaft of the driving motor is in sliding fit with the polygonal hole;
the stirring assembly comprises a rotating shaft which is in running fit with the medicine placing filter cylinder, a plurality of stirring rods which are arrayed on the rotating shaft, and a second gear which is arranged on the rotating shaft and penetrates through one end of the connecting plate and is meshed with the first gear.
Drive when rotating through the backup pad and put a medicine section of thick bamboo and rotate around the lauter tub axis and make the interior liquid medicine of decocting medicinal herbs bucket pass and put a medicine section of thick bamboo, drive first gear and put the medicine and strain the interior stirring subassembly of a section of thick bamboo and rotate the stirring and put the traditional chinese medicine of a section of thick bamboo, the effect of traditional chinese medicine water extraction in the medicine section of thick bamboo has been improved, driving motor drives the lauter tub, spiral stirring shaft and backup pad rotate, when spiral stirring shaft rotates will boil in the medicine suction lauter tub of lower part of medicine section of thick bamboo then discharge through the lateral part filtration pore and boil the different water layer highly mixings of medicine section of thick bamboo, the degree of consistency of the liquid medicine concentration in the medicine section of thick bamboo has been improved, be convenient for further improve the effect that traditional chinese medicine water extracted.
Preferably, the filter barrel with the backup pad with all there is the interval between the inner wall of medicine boiling barrel bottom, medicine boiling barrel bottom inner wall is equipped with the backing ring, the backup pad normal running fit is in the backing ring top.
Preferably, the support plate is of a cross-shaped filter plate structure, and the opening end of the filter barrel faces the inner wall of the bottom of the medicine boiling barrel.
Further, as a preferred embodiment, the semi-solid material C in step 3) can be granulated, dried, sterilized and packaged into a bagged finished product; can also be made into solid with various shapes for eating.
The invention also relates to application of the medicinal and edible composition for reducing blood sugar, wherein the semisolid material C in the step (3) is directly used as a paste formula, or is baked and dried at 60-100 ℃ for 45-60min, and the dried mixture is crushed into powder.
The medicinal and edible composition for reducing blood sugar can be added with water and stirred uniformly for drinking, or added into drinks such as milk and stirred uniformly for drinking; it can also be added into food, such as: noodles, macaroni, wheaten food, candy, biscuit, cake, etc.
The invention has the beneficial effects that: the medicinal and edible composition is prepared by using the compatibility of the traditional Chinese medicines, has natural components and no toxic or side effect, can effectively reduce blood sugar and improve immunity, and has a good prevention effect on diabetes. According to the preparation method, the medicinal properties of the traditional Chinese medicine are fully exerted in multiple decoction processes, and the effect of character complementation is achieved; in the preparation method, the proper ratio of the concentrated liquid medicine and the temperature of the concentrated liquid medicine can be controlled to be uniformly dispersed with the resistant starch and the ginseng powder to achieve better fusion, thereby not only facilitating the exertion of the drug effect, but also facilitating the processing treatment.
Drawings
Fig. 1 is a schematic perspective view of a traditional Chinese medicine extraction device according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a device for extracting traditional Chinese medicine according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a filter vat of the traditional Chinese medicine extraction device according to an embodiment of the invention.
Wherein the figures include the following reference numerals:
1-a medicine boiling barrel, 3-a supporting plate, 4-a medicine placing filter cylinder, 5-a filter barrel, 6-a spiral stirring shaft, 7-a connecting plate, 8-a first gear, 9-a rotating shaft, 10-a stirring rod, 11-a second gear, 12-a backing ring, 13-a cover ring, 14-a driving motor and 15-a polygonal hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of a medicinal and edible composition for reducing blood sugar comprises the following steps:
(1) 15g of poria cocos, 10g of Chinese wolfberry, 5g of dendrobium leaves, 6g of honey-fried licorice roots and 3g of gypsum, 8 times of water is decocted for 2 times, the decocting temperature is 80 ℃, the decocting time is 50min, the decoctions are combined, and the mixture is concentrated to 300ml of liquid medicine for later use;
(2) 15g of resistant starch and 1g of ginseng powder are uniformly mixed by a stirrer for later use;
(3) uniformly stirring 300ml of concentrated liquid medicine prepared in the step 1) and the resistant starch-ginseng mixed powder prepared in the step 2), and fully absorbing the liquid medicine by the powder to obtain a semisolid material;
(4) baking the mixture at 80 deg.C, drying, and pulverizing.
Referring to fig. 1-3, in the present embodiment, a water extracting apparatus for traditional Chinese medicine is provided, which includes: the medicine decocting device comprises a medicine decocting barrel 1, a water layer flow mixing mechanism which is rotationally matched in the medicine decocting barrel 1, a supporting plate 3 which is fixedly sleeved on the periphery of the water layer flow mixing mechanism, and medicine placing filter cylinders 4 which are circumferentially arrayed on the supporting plate 3, so that the medicine placing filter cylinders 4 and the water layer flow mixing mechanism can rotate synchronously;
the medicine placing filter cylinder 4 is internally and rotatably matched with a stirring mechanism meshed with the inner wall of the medicine boiling barrel 1, and the upper side of the medicine boiling barrel 1 is provided with a driving mechanism in sliding connection with the water layer mixed flow mechanism, so that the driving mechanism can drive the water layer mixed flow mechanism and parts connected with the water layer mixed flow mechanism to rotate.
Specifically, water layer mixed flow mechanism includes that running fit is in boiling medicine bucket 1 and with backup pad 3 and actuating mechanism be connected lauter tub 5, fixed install in lauter tub 5 and fix the spiral (mixing) shaft 6 on boiling medicine bucket 1 inner wall, be convenient for spiral (mixing) shaft 6 and lauter tub 5 synchronous rotation will boil in medicine bucket 1 lower part's suction lauter tub 5 then discharge through the lateral part filtration pore and boil the different water layer high mixings of medicine bucket 1.
Concretely, rabbling mechanism includes that running fit is putting the stirring subassembly of a section of thick bamboo 4 in the medicine, install and be strained connecting plate 7 on a section of thick bamboo 4 in putting the medicine, running fit on connecting plate 7 and with stirring subassembly and the first gear 8 of 1 inner wall meshing of bucket of decocting medicinal herbs, a plurality of tooth's socket of circumference array at 1 inner wall of bucket of decocting medicinal herbs, it strains a section of thick bamboo 4 to be convenient for put the medicine and rotates around 5 axes of filter vat and make the medicine water of 1 interior of bucket of decocting medicinal herbs pass and put a section of thick bamboo 4 in the medicine, drive first gear 8 and put the stirring subassembly rotation stirring of a section of thick bamboo 4 in the medicine and put the traditional chinese medicine of a section of thick bamboo 4.
Specifically, the stirring assembly comprises a rotating shaft 9 which is in running fit with the medicine placing filter cartridge 4, a plurality of stirring rods 10 which are arrayed on the rotating shaft 9, and a second gear 11 which is arranged at one end of the rotating shaft 9 penetrating through the connecting plate 7 and is meshed with the first gear 8, so that the rotating shaft 9 can rotate to drive the plurality of stirring rods 10 to stir the traditional Chinese medicine in the medicine placing filter cartridge 4.
It is specific, all have the interval between straining barrel 5 and backup pad 3 and the 1 bottom inner wall of decocting medicinal herbs bucket, boil 1 bottom inner wall of medicinal herbs bucket and be equipped with backing ring 12, 3 normal running fit of backup pad are in backing ring 12 tops, are convenient for all have the interval to make the liquid medicine in decocting medicinal herbs bucket 1 flow into in straining barrel 5 through straining barrel 5 and between the 1 bottom inner wall of decocting medicinal herbs bucket.
Specifically, backup pad 3 is cross filter plate structure, and 5 open ends of lauter tub are towards boiling medicine 1 bottom inner wall of bucket, and the lauter tub 5 of being convenient for is inhaled the liquid medicine of 1 bottom of bucket of decocting medicine 5 in the lauter tub 5.
Concretely, actuating mechanism is including installing the lid ring 13 on decocting the explosive barrel 1, installing the driving motor 14 in lid ring 13 center department, is equipped with one-way air outlet valve on the lid ring 13, and polygonal hole 15 has been seted up to the lauter tub 5 upside, and driving motor 14's output shaft sliding fit is in polygonal hole 15, and when being convenient for lid ring 13 was installed on decocting the explosive barrel 1, made driving motor 14 polygonal output shaft insert polygonal hole 15 in be connected with lauter tub 5.
The working principle is as follows:
after traditional Chinese medicine is placed into the medicine placing filter cylinder 4, the medicine boiling barrel 1 is heated, then the driving motor 14 is started to drive the filter cylinder 5, the spiral stirring shaft 6 and the supporting plate 3 rotate, the lower part of the medicine boiling barrel 1 is sucked into the filter cylinder 5 when the spiral stirring shaft 6 rotates, then the medicine is discharged from the side filter holes and is highly mixed with different water layers of the medicine boiling barrel 1, the supporting plate 3 drives the medicine placing filter cylinder 4 to rotate around the axis of the filter cylinder 5 to enable the medicine water in the medicine boiling barrel 1 to pass through the medicine placing filter cylinder 4 when rotating, the first gear 8 and a stirring component in the medicine placing filter cylinder 4 are driven to rotate to stir the traditional Chinese medicine in the medicine placing filter cylinder 4, and the uniformity of the concentration of the liquid medicine in the medicine boiling barrel 1 and the effect of water extraction of the traditional Chinese medicine are improved.
Example 2
The raw materials comprise: 10 parts of resistant starch, 25 parts of poria cocos, 5 parts of wolfberry, 8 parts of dendrobium leaves, 3 parts of honey-fried licorice roots, 2 parts of gypsum and 0.5 part of ginseng; the preparation method comprises the following steps:
(1) 25g of poria cocos, 5g of Chinese wolfberry, 8g of dendrobium leaves, 3g of honey-fried licorice roots and 2g of gypsum, decocting for 2 times by 15 times of water at the decocting temperature of 100 ℃ for 90 min, combining decoctions, and concentrating the decoctions to 300ml for later use;
(2) 10g of resistant starch and 0.5g of ginseng powder are uniformly mixed for standby;
(3) uniformly stirring 300ml of concentrated liquid medicine prepared in the step (1) and the resistant starch-ginseng mixed powder prepared in the step (2), and fully absorbing the liquid medicine by the powder to obtain a semisolid material;
granulating the semi-solid material, drying and sterilizing.
Example 3
The raw materials comprise: 25 parts of resistant starch, 10 parts of poria cocos, 15 parts of wolfberry, 2 parts of dendrobe leaves, 9 parts of honey-fried licorice roots, 4 parts of gypsum and 1.5 parts of ginseng; the decoction temperature is 90 deg.C, the decoction time is 70 min, and the other preparation methods are the same as example 1.
Comparative example 1
The medicinal and edible composition does not contain dendrobium leaves and honey-fried licorice roots, and the rest is the same as the embodiment 1.
Comparative example 2
The medicinal and edible composition comprises the following raw materials of effective components in parts by weight: 8 parts of resistant starch, 30 parts of poria cocos, 20 parts of wolfberry, 2 parts of dendrobe leaves and 9 parts of honey-fried licorice roots, and the rest is the same as in example 1.
Animal experiment 1
1.1 materials and methods: the composition prepared in examples 1-3 was added to 150mL of water;
1.2 main reagents and instruments: alloxan, glucose; blood glucose meter
1.3 animals: male rats, 180 ± 20 g;
1.4 grouping and administration
(1) Taking 75 healthy rats, feeding for 4 days, fasting for 4 hours, and measuring fasting blood glucose; randomly taking 10 to make a blank group;
(2) molding the hyperglycemia animal: remaining 65 rats are fasted for 24 hours, and are injected with freshly prepared alloxan with the injection amount of 60mg/kgBW.iv, after the injection is carried out for 5 days, the rats are fasted for 4 hours, the blood sugar value is measured, and the blood sugar value is more than 10mmol/L, so that the molding is successful;
(3) grouping: the successfully modeled rats in (2) were randomized into six groups: model group, model + example 1, model + example 2, model + example 3, model + control 1, model + control 2, 10 per group;
(4) the blank and model groups were fed the same volume of distilled water, 1mL/100g, model + example 1, model + example 2, model + example 3, model + control 1, model + control 2 were fed the corresponding example composition formula, 1mL/100g, for 30 consecutive days. In the above group, blood glucose (blood glucose 0 h) before meal, blood glucose 0.5h after meal, and blood glucose 2h after meal were measured, respectively;
(5) after the test was completed, all rats were fasted for 4 hours, and tail blood was taken to measure blood glucose and calculate the glucose tolerance.
Figure DEST_PATH_IMAGE002A
1.5 results of the experiment
The results of 0h blood glucose and glucose tolerance in each group of animal experiment 1 are shown in table 1.
Table 1: results of 0h blood glucose and glucose tolerance for each group of the animal experiment of the invention
Figure DEST_PATH_IMAGE004A
From the results it follows: compared with the blank group, the area AUC values under the fasting blood glucose value curve, the blood glucose value after 0.5h of glucose administration, the blood glucose value after 2h of glucose administration, and the blood glucose value curves after 0h, 0.5h and 2h of glucose administration are obviously increased.
To summarize: animal experiments show that compared with a model group, the fasting blood glucose value, the blood glucose value of 0.5h and 2h after the composition is taken in a glucose tolerance experiment, and the area under the curve of the blood glucose of 0h, 0.5h and 2h are obviously reduced.
Test of efficacy of population
The experimental subjects selected 150 cases of diabetes patients with fasting blood glucose of more than 7.8 in 25-65 years old were randomly divided into experimental group 1, experimental group 2, experimental group 3, comparative group 1 and comparative group 2, and each group had 30 people.
Functional foods were prepared according to the formulations of examples 1 to 3, respectively, and then the diabetic patients in test group 1, test group 2, and test group 3 were allowed to eat 2 times a day 30g each time before meals.
The control groups 1 and 2 eat the functional food prepared by the comparative examples 1 and 2 before meals respectively, 2 times a day, and 30g each time.
After three months, fasting blood glucose values of each group of diabetic patients were measured, and the results are shown in the following table.
Figure DEST_PATH_IMAGE006
The results show that:
1. after the subjects eat the functional food prepared by the invention for three months, the blood sugar is obviously reduced, and the reduction value is higher than that of a control group, which shows that the formula of the functional food prepared by the invention is scientific and reasonable, has the function of assisting in reducing the blood sugar, and can eat the composition at ease;
2. the effect of the hypoglycemic functional food of the embodiment 1-3 of the invention is better than that of the comparative example 1-2; wherein the functional food prepared in example 1 has the most excellent blood sugar lowering effect.

Claims (10)

1. The medicinal and edible composition for reducing blood sugar is characterized in that the raw materials of the effective components of the medicinal and edible composition in parts by weight are as follows: 10-25 parts of resistant starch, 10-25 parts of poria cocos, 5-15 parts of wolfberry, 2-8 parts of dendrobium leaves, 3-9 parts of honey-fried licorice roots, 2-4 parts of gypsum and 0.5-1.5 parts of ginseng.
2. The medicinal and edible composition for reducing blood sugar according to claim 1, wherein the raw materials of the effective components of the medicinal and edible composition in parts by weight are as follows: 10 parts of resistant starch, 25 parts of poria cocos, 5 parts of wolfberry, 8 parts of dendrobium leaves, 3 parts of honey-fried licorice roots, 2 parts of gypsum and 0.5 part of ginseng.
3. The medicinal and edible composition for reducing blood sugar according to claim 1, wherein the raw materials of the effective components of the medicinal and edible composition in parts by weight are as follows: 15 parts of resistant starch, 15 parts of poria cocos, 10 parts of wolfberry, 5 parts of dendrobium leaves, 6 parts of honey-fried licorice roots, 3 parts of gypsum and 1 part of ginseng.
4. The medicine-food homologous composition for reducing blood sugar according to claim 1, is characterized by comprising 25 parts of resistant starch, 10 parts of poria cocos, 15 parts of wolfberry, 2 parts of dendrobe leaves, 9 parts of honey-fried licorice roots, 4 parts of gypsum and 1.5 parts of ginseng.
5. The medicinal and edible composition for reducing blood glucose according to claim 1, wherein the resistant starch is canna RS3 resistant starch; canna RS3 resistant starch is preferably to type B structure, chain length DP37-100 ratio.
6. A preparation method of the medicinal and edible composition for reducing blood sugar according to any one of claims 1-5, which is characterized by comprising the following steps: the method comprises the following steps:
(1) mixing Poria, fructus Lycii, folium Dendrobii, radix Glycyrrhizae Preparata, and Gypsum Fibrosum, adding water 6-15 times of the raw materials, decocting at 80-100 deg.C for 50-90 min to obtain concentrated medicinal liquid A;
(2) stirring resistant starch and Ginseng radix powder to obtain powder B;
(3) and (3) mixing the concentrated liquid medicine A prepared in the step (1) with the powder B prepared in the step (2) at 40-60 ℃, and fully absorbing the concentrated liquid medicine A by the powder B to obtain a semi-solid material C.
7. The preparation method of the medicinal and edible composition for reducing blood sugar as claimed in claim 6, wherein in step (1), the decoction is divided into two times, the decoction is combined to obtain a concentrated liquid medicine A, and the mass ratio of the concentrated liquid medicine A to the raw material liquid in step (1) is 20-55%.
8. The preparation method of the medicinal and edible composition for reducing blood sugar as claimed in claim 6, wherein the extraction device for decocting and extracting the adopted traditional Chinese medicine comprises a decoction barrel (1), a water layer flow mixing mechanism which is rotationally matched in the decoction barrel (1), a support plate (3) which is fixedly sleeved on the periphery of the water layer flow mixing mechanism, and medicine placing filter cartridges (4) which are circumferentially arrayed on the support plate (3);
a stirring mechanism meshed with the inner wall of the medicine boiling barrel (1) is rotationally matched in the medicine placing filter cylinder (4), and a driving mechanism in sliding connection with the water layer mixed flow mechanism is arranged on the upper side of the medicine boiling barrel (1);
the water layer flow mixing mechanism comprises a filter barrel (5) which is rotationally matched in the medicine boiling barrel (1) and is connected with the supporting plate (3) and the driving mechanism, and a spiral stirring shaft (6) which is fixedly arranged in the filter barrel (5) and is fixed on the inner wall of the medicine boiling barrel (1);
the stirring mechanism comprises a stirring component which is rotationally matched in the medicine placing filter cylinder (4), a connecting plate (7) which is arranged on the medicine placing filter cylinder (4), a first gear (8) which is rotationally matched on the connecting plate (7) and is meshed with the stirring component and the inner wall of the medicine boiling barrel (1), and a plurality of tooth grooves which are circumferentially arrayed on the inner wall of the medicine boiling barrel (1);
the stirring assembly comprises a rotating shaft (9) which is in rotating fit with the medicine placing filter cylinder (4), a plurality of stirring rods (10) which are arrayed on the rotating shaft (9), and a second gear (11) which is arranged at one end of the rotating shaft (9) through the connecting plate (7) and is meshed with the first gear (8);
the driving mechanism comprises a cover ring (13) arranged on the medicine boiling barrel (1) and a driving motor (14) arranged at the center of the cover ring (13), a polygonal hole (15) is formed in the upper side of the filtering barrel (5), and the output shaft of the driving motor (14) is in sliding fit with the polygonal hole (15).
9. The preparation method of the medicinal and edible composition for reducing blood sugar as claimed in claim 8, wherein the filter barrel (5) and the support plate (3) are spaced from the inner wall of the bottom of the medicine boiling barrel (1), the inner wall of the bottom of the medicine boiling barrel (1) is provided with a backing ring (12), and the support plate (3) is rotationally fitted above the backing ring (12).
10. Use of the composition as claimed in any one of claims 1 to 5 for lowering blood glucose, wherein the semi-solid material C of step (3) is granulated or made into various solid shapes for eating.
CN202210076507.XA 2022-01-24 2022-01-24 Medicinal and edible composition for reducing blood sugar and preparation method and application thereof Pending CN114470103A (en)

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