CN1070827A - Up-to-date therapeutic agent of diabetes and method for making thereof - Google Patents
Up-to-date therapeutic agent of diabetes and method for making thereof Download PDFInfo
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Abstract
A kind of new Remedies for diabetes is a raw material with the homologous natural edible-plant of medicated diet, by the theory of Chinese medical science prescription, different qualities according to every flavor Chinese medicine, with after the pretreatment such as lyophilizing or air-dry pulverizing, solvent extraction, preparation is in proportion made powder or piece agent through ripening, sterilization more respectively.Contain rich vegetable protein, cellulose and 17 seed amino acids in the preparation, and contain plurality of active ingredients such as choline, flavone compound, para-insulin and trace element, by the comprehensive function treatment diabetes of each flavor Chinese medicine.Prescription of the present invention and manufacture method uniqueness, therapeutic effect is remarkable, has tangible economic benefit and social benefit.
Description
The present invention relates to the pharmaceutical product field, more specifically say so about the Chinese herbal medicine pharmaceutical product of treatment diabetes.
Diabetes are commonly encountered diseases frequently-occurring diseases of serious harm human health, and at present world's diabetics surpasses 100,000,000 people, and China is near 20,000,000, and the trend that increases is year by year arranged.Case fatality rate is only second to malignant tumor and cardiovascular diseases, is to jeopardize the third-largest disease of human life.
Diabetes do not heal all the life, and complication extensively and seriously.Because insulin lacks relatively or definitely in the blood, causes sugar, fat, protein metabolism disorder, causes the rising of hyperglycemia, hyperlipidemia and blood viscosity, extensively microangiopathies of the whole body appears in middle and advanced stage.Wherein 70-80% patient dies from the cardiovascular diseases, and diabetes kidney function failure and cerebrovascular are unusual to be the common cause of death of middle and elderly diabetic patient.
Both at home and abroad to the primary disease Drug therapy, run into following thorny problem at present:
1, biguanide drug: curative effect is low pays effect greatly, for a long time with producing hyperlactacidemia.
2, sulfaurea drugs is for a long time with infringement liver, kidney and hemocyte; With the sulphonamides cross allergy, the later stage produces secondary failure.
3, with producing antibody, biological activity reduces insulin for a long time, and dosage increases, and produces hyperinsulinemia, impels microangiopathies to take place and development.
The object of the present invention is to provide a kind ofly to have blood sugar lowering, blood fat reducing, improve high blood coagulation state, the mediation microcirculation, enhancing human body immunity reduces, the Remedies for diabetes of diabetes-alleviating complication.
Solution of the present invention is based on motherland's medical science to diabetes and complication pathogeny understanding and Therapeutic Principle, achieve with reference to modern pharmacological research, in motherland's medicine treasure-house, filter out: nourishing kidney-yin, QI invigorating void, change congestion, pure and impure letting out, the body resistance strengthening and constitution consolidating, the homologous natural edible-plant of medicated diet is by the theory of Chinese medical science prescription, skim the cream off milk, tool promotes endogenous secretion of insulin to reduce exogenous insulin periphery drag, increases biological activity, promotes the metabolism of sugar, reducing fat protein decomposes, make blood glucose, blood fat reduces, and microcirculation improvement reduces, diabetes-alleviating patient cardiovascular pathological changes develops.
The present invention is formulated by following component, and its constituent content is the lipid-lowering agent of (weight %): 5-42, and it is selected from Fructus Hordei Germinatus, Fructus Crataegi, Massa Medicata Fermentata, Semen Cassiae, the Rhizoma Anemarrhenae, Semen Sterculiae Lychnophorae, Semen Celosiae; The immunity of organism reinforcing agent of 5-25, it is selected from Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Polygonati; The neuroregulator of 5-30, it is selected from Semen Benincasae, Poria, Semen Phaseoli, Rhizoma Alismatis, SEMEN COICIS and Semen Plantaginis; The insulin of 5-30 is short puts agent, and it is selected from Fructus Lycii, Herba Dendrobii, Fructus Corni, Rhizoma Polygonati Odorati; The insulin synthetic catalyst of 5-30, it is selected from the Hypoylycemic agents of Semen sojae atricolor, Semen Sesami Nigrum, Semen Allii Tuberosi and 5-15, and it is selected from Fructus Cucurbitae moschatae, Semen Cassiae, Fructus Momordicae charantiae, Flos Chrysanthemi Fructus Trichosanthis.
In the therapeutic agent that is mixed with thus, contain multiple active ingredients such as vegetable protein, cellulose, choline flavone compound, para-insulin, aminoacid and minor metallic element, utilize the comprehensive function treatment diabetics of the Chinese medicine of respectively distinguishing the flavor of.
Can form several different prescriptions according to the prescription theory of the traditional Chinese medical science and be used for treatment of diabetes, a kind of preferred prescription is to be constituent with Fructus Crataegi, Rhizoma Dioscoreae, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Semen sojae atricolor, Fructus Momordicae charantiae and Poria, its constituent content is the Fructus Crataegi of (weight %): 5-30, the Rhizoma Dioscoreae of 5-25, the Semen Cassiae of 5-12, the Flos Chrysanthemi of 5-20, the Semen sojae atricolor of the Fructus Lycii 5-20 of 5-30, the Fructus Momordicae charantiae of 5-15 and the Poria of 5-30.
An important feature of the present invention is to contain abundant nutrition in the medicament, and wherein plant protein content reaches 10-20%, exceeds 2.2 times than rice.And contain 17 seed amino acids, comprise aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine phenylalanine, lysine, histidine, arginine and tryptophan, wherein arginine reaches 963.3mg/100g, lysine reaches 543.2mg/100g, leucine reaches 1117mg/100g, the aminoacid of needed by human totally can promote the long-pending of insulin to put, and particularly arginine, lysine and leucic effect are the strongest.Its constituent content sees the following form:
| Title | Content (mg/100g) | Title | Content (mg/100g) | Title | Content (mg/100g) |
| Aspartic acid threonine serine glutamic acid proline glycine | 1214.2 414.8 548.6 1559.6 511.0 378.2 | Alanine valine methionine isoleucine leucine tyrosine | 872.9 729.9 284.9 518.6 1117.0 359.5 | Phenylalanine arginine lysine histidine tryptophan | 597.9 534.2 206.4 963.3 230.4 |
In Remedies for diabetes of the present invention, also contain potassium, magnesium, calcium, zinc, ferrum, chromium (Cr in addition
3), various trace elements such as selenium, these metallic elements are the prothetic groups that constitute the multiple metalloenzyme of body, to the biosynthesis of insulin and discharged catalytic action.Each chemical element content sees the following form:
| Title | Content (mg/kg) | Title | Content (mg/kg) | Title | Content (mg/kg) |
| Potassium magnesium selenium | 946.2 1561 0.12 | Calcium zinc | 1478 17.81 | Siderochrome (Cr 3) | 168.4 22.62 |
Another important feature of the present invention is to contain abundant water-soluble cellulose and anthraquinone compounds in the medicament, and content of cellulose reaches 5-20%, can promote gastrointestinal emptying, reduces sugar, fat absorption, helps blood glucose and reduces.Also contain abundant choline material and flavone compound in this medicament, wherein flavonoid content for the 1.2-2.0% flavone compound can blood fat reducing, the sticking microcirculation that promotes of blood falls, increase the islets of langerhans blood perfusion, help the synthetic and secretion of insulin.
For showing the present invention to the treatment of diabetes effect, the present invention is through the clinical observation of 100 routine systems, and select medical history, the state of an illness, year make, sex and suitable diabetics 72 examples of former Therapeutic Method are matched group.From being in hospital and endocrine special outpatient clinic selection case, press the diabetes diagnosis standard that WHO formulated in 1980, the maturity-onset diabetes patient who makes a definite diagnosis, on the basis of dietetic therapy and medicine (oral antidiabetic drug and insulin) treatment, fasting glucose 〉=7.2mmol/L person is the object of observation, wherein male 46 examples, women 54 examples, year makes 27-70 year, course of disease half a year-35 year.Test group: on former treatment basis, the lipid lowerers of stopping using adds the present invention.Matched group: blood sugar lowering, blood fat reducing treatment routinely, wherein hypoglycemic medicine, kind usage and dosage and test group are complementary, and lipid lowerers adopts the import fenofibrate.Adopt same procedure to make regular check on fasting glucose and blood fat, three months observation periods, one month is a course of treatment, totally three courses of treatment.
Instructions of taking: 20 gram/bags, day clothes 3 times, ante cibum, boiled water was taken after mixing it with water.Clinical test results is as table (1,2)
Table 1 is taken the present invention front and back insulin, diamicron consumption and change of blood sugar
| Case load | Insulin dosage (u/d) | Diamicron consumption (mg/d) | Fasting glucose decline (mmd/L) | ||||
| Before | After | Before | After | Before | After | ||
| Test group matched group t p | 100 72 | 46.82 45.89 0.29 ＞0.05 | 20.59 49.18 10.87 ＜0.01 | 260 240 0.26 ＞0.05 | 60 280 8.74 ＜0.01 | 11.7 ±3.69 11.37 ±3.18 0.54 ＞0.05 | 7.85 ±2.32 9.89 ±3.01 2.46 ＜0.01 |
Table 2 is taken the present invention's front and back lipid lowerers consumption and the average concentration change of blood fat
| Case load | Fenofibrate consumption (mg/d) | Serum cholesterol meansigma methods (mmol/L) | Serum levels of triglyceride meansigma methods (mmol/L) | ||||
| Before | After | Before | After | Before | After | ||
| Test group matched group t p | 82 55 | 0 300 | 0 300 | 5.72 ±1.10 5.87 ±1.06 0.84 ＞0.05 | 4.72 ±0.82 5.13 ±0.97 4.32 ＜0.05 | 2.12 ±107 2.08 ±0.93 0.76 ＞0.05 | 1.42 ±0.53 2.01 ±0.32 3.65 ＜0.05 |
As can be seen from Table 1, fasting glucose concentration is similar substantially with the hypoglycemic medicine consumption before two groups of tests, p＞0.05, and blood glucose descended after test group was taken electuary of the present invention, and the antidiabetic drug consumption is than original minimizing 1/3～1/2.
Table 2 data show, serum cholesterol and triglyceride mean concentration all do not have significant difference before two groups of tests, but after test group takes the present invention, do not use any other lipid lowerers, can reach the blood fat reducing purpose.
We have also measured the test diabetes patient, take the relevant data of the present invention front and back body's immunity, and compare with the normal person, the results are shown in Table 3.
Table 3 T Lymphocyte Subsets Determination result
| The example number | okT (%) | okT 4(%) | okT 8(%) | okT 4/okT 8 | ||
| Test group | Before the treatment | 46 | 64.47± 6.13 | 37.47± 4.27 | 31.48± 3.67 | 1.27±0.13 |
| After the treatment | 46 | 64.37± 7.82 | 38.91± 4.12 | 26.57± 4.32 | 1.43±0.32 | |
| Matched group | 30 | 64.36± 8.71 | 38.91± 4.12 | 25.43± 4.17 | 1.46±0.24 | |
The detection method of T cell subsets is to adopt conventional alkaline phosphorus enzyme alkali resistance phosphoric acid enzyme process, is provided by the laboratory, the court.Determination data shows that diabetics is OKT before taking medicine of the present invention
8Be higher than the normal person significantly, OKT
4/ OKT
8Ratio obviously reduces, and takes after the medicine of the present invention, and the two all roughly recovers normal, shows that medicine of the present invention has the enhancing human body immunity function.
Test statistics shows: with medicament of the present invention 100 diabeticss are done therapeutic test, that obtains significant curative effect accounts for 52%, substantially effectively accounts for 43%, and invalid accounts for 4%, and total effective rate reaches 96%.
Another important feature of the present invention is: the producer method of Remedies for diabetes provided by the invention, be different from general Chinese medicine processing method, traditional Chinese medicine processing method is with being decocted in water for oral dose, or be difficult to make full use of with this processing method active ingredient of solvent extraction, the present invention also is different from electuary used in the common Chinese patent medicine, pill, must sugaring just can impel the disintegrate of medicine grain in the electuary, then contain Mel in the pill, they all are not suitable for diabetics and use.Medicament processing method provided by the invention, it is different qualities according to every herbal medicine, handle respectively, substep is processed essence and is got, so that fully keep the active ingredient in each herbal medicine, thereafter in proportion, preparation successively, make said Remedies for diabetes through the ripening sterilization treatment, its key step comprises:
A) every herbal medicine is ground into 120 order fine powders after the subitem pretreatment;
B) in proportion according to medicine hygroscopicity difference, pairing cooperates to mix makes loose powder;
C) ripening, sterilization treatment;
D) make the block agent for the treatment of diabetes powder or similar cookies size.
An important feature of the processing method that the present invention is used is that each herbal medicine carries out pretreatment respectively, the active ingredient of as far as possible preserving medicine, and it comprises following several preprocess method:
E) the easy medicine of the moisture absorption of part respectively to be ground into 120 purpose fine powders behind the low-temperature freeze drying, is pulverized after all adopting lyophilization as Fructus Lycii, Rhizoma Polygonati Odorati, Fructus Corni, Semen Cassiae, is mixed with loose powder with other powder thereafter;
F) general medicine is ground into 120 order fine powders after all air-dry at normal temperatures.As: the decoction of all putting together of Semen Coicis Rhizoma Dioscoreae, Poria, traditional Chinese medicine using method, the present invention has then avoided decocting process, becomes fine powder with air-dry back pulverization process, has kept active ingredient wherein so better.
G), wherein use behind the active ingredient removal abnormal flavour with solvent extraction for some specific drugs.As using behind the Fructus Cucurbitae moschatae removal moisture, Semen sojae atricolor, big Semen Glycines are then removed bits, use behind the extraction albumen; Fructus Momordicae charantiae is then used alcohol extraction, discards residue and removes bitterness, uses after producing Charantin, and the preparation that obtains of processing does not have the bitterness of common Chinese medicine thus, but fragrant and sweet agreeable to the taste.
The powder of making as stated above carries out the ripening sterilization treatment after being mixed with powder again under 110-100 ℃, the ripening disinfecting action here is to adopt step type cooling ripening sterilization, temperature is raised to 110 ℃ rapidly, and segmentation thereafter drops to 100 ℃, and the ripening sterilization time is 10～30 minutes.
Preparation after the maturation process is powder, also can be reprocessed into the solid block dosage form of similar cookies size, need add an amount of binding agent this moment again, and compression moulding under negative pressure, drying and with the vacuum type packing can obtain bulk block Remedies for diabetes at this moment.
The invention will be further described for concrete instance of following reuse:
1, gets 20 kilograms of Fructus Crataegis, drying and crushing to 120 order fine powder;
2, get 5.5 kilograms of Fructus Lycii, after-15 ℃ of following lyophilizations, processing powder is broken into 120 order fineness, and other gets 4.5 kilograms in Fructus Momordicae charantiae, thinly slices, extract with Diluted Alcohol solution, discard residue, after extracting solution concentrated, the residue drying obtained elementary Charantin, mix with above-mentioned Fructus Lycii powder again, and cooperate with Fructus Crataegi powder and to make loose powder;
3, get 5.5 kilograms of Flos Chrysanthemis and 6.5 kilograms of Semen Cassiaes, lyophilizing respectively, be ground into fine powder;
4, get 16.5 kilograms in 8.5 kilograms of Semen Coiciss, 7.5 kilograms of Rhizoma Dioscoreaes, 5.5 kilograms in Poria and Semen sojae atricolor, be ground into 120 order fine powders after air-dry;
5, above-mentioned several components are mixed in proportion after, under 110-100 ℃, carried out ripening, sterilization treatment 30 minutes, can obtain treating diabetes powder finished product.
The several concrete instances of following reuse further specify effect of the present invention
Example 1: grandson, the man, 60 years old, it was surplus to suffer from diabetes (II type) 5 years, and on May 13rd, 1991 was admitted to hospital for the second time, obeyed 30 of diabetes pilles the day before yesterday of being admitted to hospital, fasting glucose 13.6mmol/L.Xerostomia, polydipsia, constipation, abdominal distention, weak.Be admitted to hospital the back successively with Drug therapy four wheat harvesting periods such as diamicron, insulin, fenofibrate, glipizides, insulin dosage increases to 55U/ day, checks fasting glucose 13.5mmol/L, cholesterol 7.1mmol/L, triglyceride 1.73mmol/L, blood examination is high viscosity and high coagulant state.
Add every day of the present invention 4 times from October 5th, 1991, each 1 bag (every bag 20g) so far.Take the present invention after 14 days fasting glucose reduce to 9.03mmol/L, on October 23rd, 1991 left hospital.Three weeks withdrew all antidiabetic drugs after leaving hospital, subtract gradually from the 4th week and use insulin, successively decrease 4U/ day, at every turn from insulin injection 8U/ day every day on the 5th May in 1992.Check glucose in urine-,-, ±, fasting glucose is reduced to 5.29mmol/L, constipation, excessive thirst, phenomenon such as weak disappear.
Example 2, open *, man, 74 years old.Suffered from non-insulin-dependent diabetes mellitus 35 years, and merged coronary heart disease, peripheral neuropathy, dysuria, once several hospitalization.While in hospital is obeyed 2 slices/day of diamicron with insulin 44U/ day, and fasting glucose fluctuates at 11.6-2.1mmol/L.After taking the present invention, diamicron is kept to 1 slice/day, and insulin 18U/ day, fasting glucose is reduced to 7.2-7.8mmol/L, weight increase, and thirsty weak disappearance, urine is logical.
Example 3, the king * *, the woman, 56 years old, non-insulin-dependent diabetes mellitus, medical history 14 years since 1985, has had six months hospitalization or rescue every year, is critically ill for several times.Before accepting the present invention and treating: fasting glucose 21-22.4mmol/L, with insulin 56U/ day, tens kinds of 4 of diamicron and other lipid lowerers, on October 25th, 1991 began to take the present invention so far, after ten months, insulin dosage is reduced to 48U/ day, withdraws other medicines.92 year August 12, the daily inspection fasting glucose was reduced to 11.0mmol/L, and patient is energetic, was not in hospital in nearly 1 year, take care of oneself, and weight increase, other complication obviously alleviate the blood fat chemical examination and recover normal fully.（TCh 4.5mmol/L;TG 1.25mmol/L;HDL 45mmol/L.）
More than clinical use result show that the present invention has following advantage:
1, to select the homologous natural edible-plant of medicated diet for use be raw material in the present invention, and each component conforms to pharmaceutical control law.Utilize the comprehensive function treatment diabetes of the Chinese medicine of respectively distinguishing the flavor of, do not have chemical sweeting agent, nontoxic to human body.
2, the present invention need not decoct, no bitterness sense, and nutritious, famine is then eaten, and then drinks yearningly, and taking convenience meets the state food health legislation.
3, light disease person can use separately.Can use with other antidiabetic drugs and insulin combination than severe disease disease, but can significantly reduce the use amount of common antidiabetic drug and insulin, therapeutic effect obviously increases, and can alleviate or eliminate other complication, the immunity of enhancing body significantly.
4, the person that is combined the hyperlipidemia, the present invention can replace expensive import lipid lowerers, and (fenofibrate, per 100/224 yuan) to middle and advanced stage severe diabetes patient, are used product of the present invention and can partly be replaced expensive import antidiabetic drug (diamicron and glipizide).
Prescription of the present invention in a word and manufacture method uniqueness, evident in efficacy, have tangible economic benefit and social benefit.
The several actual prescriptions of following reuse further specify the present invention and are not confined to certainly among these several embodiment.
Example 12
(gram) (gram)
Fructus Crataegi 20 17.5
Rhizoma Dioscoreae 7.5 8.5
Semen Coicis 8.5 7.5
Semen Cassiae 6.5 5.5
Flos Chrysanthemi 5.5 6.5
Fructus Lycii 5.5 6.5
Semen sojae atricolor 16.5 17.0
Poria 5.5 6.5
Fructus Momordicae charantiae 4.5 4.5
Observe through 100 examples, I type, type patient all are suitable for, obviously hypoglycemic lipid-lowering effect reduces or prevents the generation and the development of complication.Can singly use early stage light-duty patient, and replace the blood sugar lowering chemicals, the centering patients with terminal with the chemical Antidiabetic Drug coupling, can reduce the chemical sugar-lowering survival dose.
Example 3:
Rhizoma Dioscoreae 15g Fructus Hordei Germinatus 10g Fructus Lycii 8g Poria 9g Semen Cassiae 10g Semen Phaseoli 10g Semen sojae atricolor 15g
Observe through 15 examples, the blood sugar reducing function onset is slow, sees change of serum C r
3Deficient patients, blood sugar reducing function a little less than, a little less than the effect for reducing fat, the diuresis effect is obvious.
Example 4:
The big Semen Glycines Radix Et Rhizoma Rhei of Radix Astragali 30g Fructus Crataegi 15g Flos Chrysanthemi 10g Semen Cassiae 10g bean 20g Semen Benincasae 10g Semen Celosiae 9g
Observe through 19 examples, effect for reducing fat is obvious, a little less than the blood sugar reducing function.Hypotensive effect is gentle and lasting, to benign hypertension for well.
Example 5:
The big Semen sojae atricolor 20g of SEMEN COICIS 10g Fructus Corni 10g Rhizoma Dioscoreae 15g Fructus Crataegi 15g Fructus Hordei Germinatus 10g Rhizoma Alismatis 10g
Observe 8 examples with self cross-reference method, consumer edema is obvious, especially to the hyperinsulinemia person that causes the lower limbs edema.Blood sugar reducing function is medium, and it is effective to eliminate abdominal distention, and the serum microelement analysis result shows Cr
3The deficient patients blood sugar reducing function is poor.
Example 6:
Flos Chrysanthemi 15g Fructus Lycii 10g Fructus Crataegi 15g Exocarpium Benincasae 10g testa mungo 10g Rhizoma Alismatis 10g Semen Celosiae 9g
Observe through 9 examples, single blood sugar lowering, effect for reducing fat used is combined nephropathy change person all than relaxing, and it is better to eliminate edema of lower limbs, and the constipation that plant function disorder person causes is not almost had effect.
Example 7:
The big Semen Glycines 20g of Poria 10g Radix Astragali 20g Fructus Hordei Germinatus 10g Semen Cassiae 10g Flos Chrysanthemi 15g Semen Phaseoli 15g
Observe through 14 examples, to Cr in the serum
3Deficient patients, the type patient, blood sugar reducing function is obvious, and anti-infectious function is obvious, to change of serum C r
3Normal person's blood sugar reducing function is general, and effect for reducing fat is not obvious, eliminates constipation, the abdominal distention effect is obvious, and sedation is arranged, the person that is particularly useful for the senile insomnia.
Claims (11)
1, a kind of Remedies for diabetes, form by multiple prepared from traditional Chinese medicines, the raw material that it is characterized in that being used to preparing therapeutic agent is some medicated diet homologies, has nourishing kidney-yin, QI invigorating void, changes congestion, the pure and impure natural edible-plant of letting out with the body resistance strengthening and constitution consolidating, and its constituent content is (weight %):
The 5-42 lipid-lowering agent, it is selected from Fructus Hordei Germinatus, Fructus Crataegi, Massa Medicata Fermentata, Semen Cassiae, the Rhizoma Anemarrhenae, Semen Sterculiae Lychnophorae, Semen Celosiae;
5-25 immunity of organism reinforcing agent, it is selected from Rhizoma Dioscoreae, the Radix Astragali, Rhizoma Polygonati;
The 5-30 neuroregulator, it is selected from Semen Benincasae, Poria, Semen Phaseoli, Rhizoma Alismatis, SEMEN COICIS, Semen phaseoli radiati, Semen Plantaginis;
The 5-30 insulin is short puts agent, and it is selected from Fructus Lycii, Rhizoma Polygonati Odorati, Fructus Corni, Herba Dendrobii;
5-30 insulin synthetic catalyst, it is selected from Semen sojae atricolor, big Semen Glycines, Semen Sesami Nigrum, Semen Allii Tuberosi;
The 5-35 Hypoylycemic agents, it is selected from Fructus Cucurbitae moschatae, Fructus Momordicae charantiae, Semen Cassiae, Flos Chrysanthemi, Fructus Trichosanthis.
In the treating diabetes electuary that is mixed with thus, contain plurality of active ingredients such as choline, flavone compound, para-insulin, vegetable protein, cellulose, aminoacid and numerous minor metallic elements.
2, according to the described Remedies for diabetes of claim 1, it is characterized in that selecting for use the Remedies for diabetes of Fructus Crataegi, Rhizoma Dioscoreae, Semen Cassiae, Flos Chrysanthemi, Fructus Lycii, Semen sojae atricolor, Fructus Momordicae charantiae and Poria composition, its constituent content is the Fructus Crataegi of (weight %): 5-30, the Rhizoma Dioscoreae of 5-25, the Semen Cassiae of 5-12, the Flos Chrysanthemi of 5-20, the Fructus Lycii of 5-30, the Semen sojae atricolor of 5-30, the Fructus Momordicae charantiae of 5-15 and the Poria of 5-30.
3, according to the described Remedies for diabetes of claim 1, it is characterized in that containing in the preparation 17 seed amino acids such as aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histidine, arginine and tryptophan, contain arginine 936mg in wherein per 100 restraint agent, lysine 534.2mg is more than the leucine 1117mg.
4, according to the described Remedies for diabetes of claim 1, the content that it is characterized in that vegetable protein in the preparation is 10-20%.
5, according to the described Remedies for diabetes of claim 1, it is characterized in that containing in the preparation ferrum, calcium, zinc, chromium, potassium, magnesium, selenium, etc. various trace elements.
6,, it is characterized in that cellulosic content is 5-20% in the preparation according to the described Remedies for diabetes of claim 1.
7,, it is characterized in that content of flavonoids is 1.2-2.0% in the preparation according to the described Remedies for diabetes of claim 1.
8, according to the production method of the described Remedies for diabetes of claim 1, it is characterized in that different qualities according to every herbal medicine, carry out pretreatment with distinct methods respectively, substep is processed essence and is got, thereafter in proportion, successively preparation is made said Remedies for diabetes through ripening, sterilization treatment, and its key step comprises:
A, every herbal medicine are ground into 120 order fine powders after the subitem pretreatment;
B, in proportion according to medicine hygroscopicity difference, pairing cooperate to mix makes loose powder;
C, ripening, sterilization treatment;
D, the block agent of making treating diabetes powder or similar cookies size.
9, according to the described production method of claim 8, said subitem gives processing procedure in the operating procedure (a), it is characterized in that including following several preprocess method:
E, part be the medicine of the moisture absorption easily, respectively to be ground into 120 order fine powders behind the low-temperature freeze drying;
F, the air-dry at normal temperatures back of general medicine pulverize separately become 120 order fine powders;
G, part specific drugs with solvent extraction effective ingredient wherein, use after removing abnormal flavour.
10, according to the described production method of claim 8, it is characterized in that said ripening in the operating procedure (c), sterilization treatment are a kind of staged cooling ripening, Biocidal treatment method, curing temperature is 110-100 ℃, the curing time is 10-30 minute.
11, according to the described production method of claim 8, the said Remedies for diabetes of making block dosage form in the operating procedure (d) is characterized in that in the loose powder needing to add suitable binding agent, and under negative pressure dry die mould.
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| CN 92106756 CN1070827A (en) | 1992-10-26 | 1992-10-26 | Up-to-date therapeutic agent of diabetes and method for making thereof |
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| CN 92106756 CN1070827A (en) | 1992-10-26 | 1992-10-26 | Up-to-date therapeutic agent of diabetes and method for making thereof |
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| CN102783636A (en) * | 2012-06-04 | 2012-11-21 | 于长富 | Food nutrition supplement for prophylaxis and treatment of diabetes and application thereof |
| CN102940251A (en) * | 2012-11-21 | 2013-02-27 | 许伯宗 | Health-care food for reducing blood sugar and blood fat |
| CN103005439A (en) * | 2012-12-20 | 2013-04-03 | 福建美地有机农业有限公司 | Bitter gourd compound lipid-lowering oral solution and preparation method thereof |
| CN104042974A (en) * | 2014-06-07 | 2014-09-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicament for treating diabetes mellitus |
| CN106619696A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Compound blood glucose lowering preparation |
| CN115996645A (en) * | 2020-06-30 | 2023-04-21 | 庆尚国立大学校 产学协力团 | Composition for preventing, improving or treating diseases caused by nitration of tyrosine in protein comprising tyrosine as active ingredient |
-
1992
- 1992-10-26 CN CN 92106756 patent/CN1070827A/en active Pending
Cited By (9)
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| US8314080B2 (en) | 2010-04-06 | 2012-11-20 | Kuwait University | Method of treating type I diabetes |
| CN102783636A (en) * | 2012-06-04 | 2012-11-21 | 于长富 | Food nutrition supplement for prophylaxis and treatment of diabetes and application thereof |
| CN102940251A (en) * | 2012-11-21 | 2013-02-27 | 许伯宗 | Health-care food for reducing blood sugar and blood fat |
| CN102940251B (en) * | 2012-11-21 | 2014-09-03 | 许伯宗 | Health-care food for reducing blood sugar and blood fat |
| CN103005439A (en) * | 2012-12-20 | 2013-04-03 | 福建美地有机农业有限公司 | Bitter gourd compound lipid-lowering oral solution and preparation method thereof |
| CN103005439B (en) * | 2012-12-20 | 2014-02-19 | 福建美地有机农业有限公司 | Bitter gourd compound lipid-lowering oral solution and preparation method thereof |
| CN104042974A (en) * | 2014-06-07 | 2014-09-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicament for treating diabetes mellitus |
| CN106619696A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Compound blood glucose lowering preparation |
| CN115996645A (en) * | 2020-06-30 | 2023-04-21 | 庆尚国立大学校 产学协力团 | Composition for preventing, improving or treating diseases caused by nitration of tyrosine in protein comprising tyrosine as active ingredient |
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