CN1336934A - 用作hiv蛋白酶抑制剂的含有n－末端取代苄基的双氨基酸磺胺 - Google Patents
用作hiv蛋白酶抑制剂的含有n－末端取代苄基的双氨基酸磺胺 Download PDFInfo
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- CN1336934A CN1336934A CN00802755A CN00802755A CN1336934A CN 1336934 A CN1336934 A CN 1336934A CN 00802755 A CN00802755 A CN 00802755A CN 00802755 A CN00802755 A CN 00802755A CN 1336934 A CN1336934 A CN 1336934A
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000838 tipranavir Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11574699P | 1999-01-13 | 1999-01-13 | |
| US60/115,746 | 1999-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1336934A true CN1336934A (zh) | 2002-02-20 |
Family
ID=22363180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00802755A Pending CN1336934A (zh) | 1999-01-13 | 2000-01-13 | 用作hiv蛋白酶抑制剂的含有n－末端取代苄基的双氨基酸磺胺 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1140983A1 (no) |
| JP (1) | JP2002536298A (no) |
| KR (1) | KR20010101478A (no) |
| CN (1) | CN1336934A (no) |
| AU (1) | AU2725700A (no) |
| BR (1) | BR0007854A (no) |
| CA (1) | CA2353088A1 (no) |
| CZ (1) | CZ20012435A3 (no) |
| HU (1) | HUP0105235A3 (no) |
| IL (1) | IL143763A0 (no) |
| NO (1) | NO20013338L (no) |
| PL (1) | PL349774A1 (no) |
| SK (1) | SK9522001A3 (no) |
| TR (1) | TR200102033T2 (no) |
| WO (1) | WO2000042060A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| EP1188766A1 (en) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US20020022659A1 (en) * | 2000-07-19 | 2002-02-21 | Harris Gregory D. | Crystalline and salt forms of an HIV protease inhibitor |
| US20020022742A1 (en) * | 2000-07-19 | 2002-02-21 | Harris Gregory D. | Salt forms of an HIV protease inhibitor |
| US6617310B2 (en) * | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE218541T1 (de) * | 1992-08-25 | 2002-06-15 | Searle & Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| DK0715618T3 (da) * | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
-
2000
- 2000-01-13 IL IL14376300A patent/IL143763A0/xx unknown
- 2000-01-13 EP EP00905604A patent/EP1140983A1/en not_active Withdrawn
- 2000-01-13 KR KR1020017008803A patent/KR20010101478A/ko not_active Application Discontinuation
- 2000-01-13 AU AU27257/00A patent/AU2725700A/en not_active Abandoned
- 2000-01-13 CZ CZ20012435A patent/CZ20012435A3/cs unknown
- 2000-01-13 HU HU0105235A patent/HUP0105235A3/hu unknown
- 2000-01-13 BR BR0007854-9A patent/BR0007854A/pt not_active IP Right Cessation
- 2000-01-13 CA CA002353088A patent/CA2353088A1/en not_active Abandoned
- 2000-01-13 CN CN00802755A patent/CN1336934A/zh active Pending
- 2000-01-13 JP JP2000593627A patent/JP2002536298A/ja active Pending
- 2000-01-13 SK SK952-2001A patent/SK9522001A3/sk unknown
- 2000-01-13 PL PL00349774A patent/PL349774A1/xx not_active Application Discontinuation
- 2000-01-13 TR TR2001/02033T patent/TR200102033T2/xx unknown
- 2000-01-13 WO PCT/US2000/000820 patent/WO2000042060A1/en not_active Application Discontinuation
-
2001
- 2001-07-05 NO NO20013338A patent/NO20013338L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20013338L (no) | 2001-09-13 |
| WO2000042060A1 (en) | 2000-07-20 |
| EP1140983A1 (en) | 2001-10-10 |
| CZ20012435A3 (cs) | 2002-02-13 |
| NO20013338D0 (no) | 2001-07-05 |
| TR200102033T2 (tr) | 2001-12-21 |
| SK9522001A3 (en) | 2002-03-05 |
| HUP0105235A3 (en) | 2002-08-28 |
| KR20010101478A (ko) | 2001-11-14 |
| PL349774A1 (en) | 2002-09-09 |
| JP2002536298A (ja) | 2002-10-29 |
| BR0007854A (pt) | 2002-01-15 |
| HUP0105235A2 (hu) | 2002-04-29 |
| IL143763A0 (en) | 2002-04-21 |
| CA2353088A1 (en) | 2000-07-20 |
| AU2725700A (en) | 2000-08-01 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |