TR200102033T2 - HIV proteaz inhibitörleri olarak bis-amino asit sülfonamitler. - Google Patents

HIV proteaz inhibitörleri olarak bis-amino asit sülfonamitler.

Info

Publication number
TR200102033T2
TR200102033T2 TR2001/02033T TR200102033T TR200102033T2 TR 200102033 T2 TR200102033 T2 TR 200102033T2 TR 2001/02033 T TR2001/02033 T TR 2001/02033T TR 200102033 T TR200102033 T TR 200102033T TR 200102033 T2 TR200102033 T2 TR 200102033T2
Authority
TR
Turkey
Prior art keywords
bis
amino acid
protease inhibitors
hiv protease
acid sulfonamides
Prior art date
Application number
TR2001/02033T
Other languages
English (en)
Inventor
F. Kaltenbach Robert
L. Trainor George
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of TR200102033T2 publication Critical patent/TR200102033T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bu bulus genel olarak, HIV proteaz inhibitörleri olarak yararli, asagidaki (I) formülüne sahip: ornatilmis benzil aminler içeren bis-amino asit sülfonamitlere ya da bunlarin stereoizomer biçimlerine, stereoizomer karisimlarina ya da ilaç sanayiinde kullanilmaya uygun tuz biçimlerine, bunlari içeren ilaç bilesimlerine ve teshis kitlerine, bunlarin, virüs enfeksiyonlarini ya da ayraçlari olarak kullanilma yöntemlerine ve ara ürünlere ve bunlari üretme proseslerine iliskindir.
TR2001/02033T 1999-01-13 2000-01-13 HIV proteaz inhibitörleri olarak bis-amino asit sülfonamitler. TR200102033T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13

Publications (1)

Publication Number Publication Date
TR200102033T2 true TR200102033T2 (tr) 2001-12-21

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02033T TR200102033T2 (tr) 1999-01-13 2000-01-13 HIV proteaz inhibitörleri olarak bis-amino asit sülfonamitler.

Country Status (15)

Country Link
EP (1) EP1140983A1 (tr)
JP (1) JP2002536298A (tr)
KR (1) KR20010101478A (tr)
CN (1) CN1336934A (tr)
AU (1) AU2725700A (tr)
BR (1) BR0007854A (tr)
CA (1) CA2353088A1 (tr)
CZ (1) CZ20012435A3 (tr)
HU (1) HUP0105235A3 (tr)
IL (1) IL143763A0 (tr)
NO (1) NO20013338L (tr)
PL (1) PL349774A1 (tr)
SK (1) SK9522001A3 (tr)
TR (1) TR200102033T2 (tr)
WO (1) WO2000042060A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2123065T3 (es) * 1992-08-25 1999-01-01 Searle & Co Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
DE69415326T2 (de) * 1993-08-24 1999-06-02 G.D. Searle & Co., Chicago, Ill. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
CA2353088A1 (en) 2000-07-20
JP2002536298A (ja) 2002-10-29
HUP0105235A2 (hu) 2002-04-29
NO20013338L (no) 2001-09-13
BR0007854A (pt) 2002-01-15
HUP0105235A3 (en) 2002-08-28
CN1336934A (zh) 2002-02-20
AU2725700A (en) 2000-08-01
WO2000042060A1 (en) 2000-07-20
EP1140983A1 (en) 2001-10-10
SK9522001A3 (en) 2002-03-05
CZ20012435A3 (cs) 2002-02-13
NO20013338D0 (no) 2001-07-05
IL143763A0 (en) 2002-04-21
PL349774A1 (en) 2002-09-09
KR20010101478A (ko) 2001-11-14

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