CN1312129C - 盐酸多奈哌齐的多晶型物及其制备方法 - Google Patents

盐酸多奈哌齐的多晶型物及其制备方法 Download PDF

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Publication number
CN1312129C
CN1312129C CNB200510075915XA CN200510075915A CN1312129C CN 1312129 C CN1312129 C CN 1312129C CN B200510075915X A CNB200510075915X A CN B200510075915XA CN 200510075915 A CN200510075915 A CN 200510075915A CN 1312129 C CN1312129 C CN 1312129C
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China
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polymorphic form
dissolved
gram
solution
hydrochloric acid
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Expired - Fee Related
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CNB200510075915XA
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English (en)
Chinese (zh)
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CN1699343A (zh
Inventor
今井昭生
渡边英明
梶间隆
石滨泰
大昭代
田中智英
奈良部幸夫
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Sanitary Material R&d Management Co ltd
Eisai Co Ltd
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Sanitary Material R&d Management Co ltd
Eisai Co Ltd
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Publication of CN1699343A publication Critical patent/CN1699343A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CNB200510075915XA 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物及其制备方法 Expired - Fee Related CN1312129C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
JP146293/96 1996-06-07
WOPCT/JP96/03881 1996-12-27
US08/774,802 1996-12-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB971952639A Division CN1207282C (zh) 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物（iii），其制备方法及用途

Publications (2)

Publication Number Publication Date
CN1699343A CN1699343A (zh) 2005-11-23
CN1312129C true CN1312129C (zh) 2007-04-25

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CNB200510075915XA Expired - Fee Related CN1312129C (zh) 1996-06-07 1997-06-06 盐酸多奈哌齐的多晶型物及其制备方法

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Country Link
US (1) US6140321A (https=)
JP (2) JP2005015486A (https=)
KR (1) KR100545851B1 (https=)
CN (1) CN1312129C (https=)
AT (1) ATE445603T1 (https=)
AU (1) AU1153097A (https=)
CA (1) CA2516108C (https=)
DE (1) DE69739622D1 (https=)
DK (1) DK1211243T3 (https=)
ES (1) ES2330997T3 (https=)
HU (1) HUP0900417A3 (https=)
PT (1) PT1211243E (https=)
SI (1) SI22888B (https=)
UA (1) UA60307C2 (https=)
WO (1) WO1997046526A1 (https=)
ZA (1) ZA975064B (https=)

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JP2005015486A (ja) 2005-01-20
JP2009040783A (ja) 2009-02-26
ZA975064B (en) 1998-04-01
SI22888A (sl) 2010-04-30
AU1153097A (en) 1998-01-05
WO1997046526A1 (en) 1997-12-11
DE69739622D1 (de) 2009-11-26
KR100545851B1 (ko) 2006-01-24
PT1211243E (pt) 2009-11-06
DK1211243T3 (da) 2010-02-08
ATE445603T1 (de) 2009-10-15
KR20040104707A (ko) 2004-12-10
CA2516108C (en) 2008-12-02
CN1699343A (zh) 2005-11-23
HU0900417D0 (en) 2009-08-28
SI22888B (sl) 2010-06-30
UA60307C2 (uk) 2003-10-15
CA2516108A1 (en) 1997-12-11
HK1080078A1 (en) 2006-04-21
HUP0900417A3 (en) 2012-12-28
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