CN1305386A - 通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 - Google Patents
通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 Download PDFInfo
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- CN1305386A CN1305386A CN99807249A CN99807249A CN1305386A CN 1305386 A CN1305386 A CN 1305386A CN 99807249 A CN99807249 A CN 99807249A CN 99807249 A CN99807249 A CN 99807249A CN 1305386 A CN1305386 A CN 1305386A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (27)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8186398P | 1998-04-15 | 1998-04-15 | |
US60/081,863 | 1998-04-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1305386A true CN1305386A (zh) | 2001-07-25 |
CN1318092C CN1318092C (zh) | 2007-05-30 |
Family
ID=22166892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB998072494A Expired - Fee Related CN1318092C (zh) | 1998-04-15 | 1999-04-15 | 含有抗体-细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物 |
Country Status (19)
Country | Link |
---|---|
US (1) | US20040180035A1 (zh) |
EP (1) | EP1071468B1 (zh) |
JP (1) | JP2002511432A (zh) |
CN (1) | CN1318092C (zh) |
AT (1) | ATE329622T1 (zh) |
AU (1) | AU758860B2 (zh) |
BR (1) | BR9909583A (zh) |
CA (1) | CA2328076C (zh) |
CZ (1) | CZ20003767A3 (zh) |
DE (1) | DE69931908T2 (zh) |
ES (1) | ES2267263T3 (zh) |
HK (1) | HK1038882A1 (zh) |
HU (1) | HUP0101352A3 (zh) |
MX (1) | MXPA00010070A (zh) |
NO (1) | NO20005155L (zh) |
PL (1) | PL343462A1 (zh) |
RU (1) | RU2229305C2 (zh) |
WO (1) | WO1999052562A2 (zh) |
ZA (1) | ZA200005475B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104830901A (zh) * | 2015-01-21 | 2015-08-12 | 武汉友芝友生物制药有限公司 | 一种鼠肿瘤模型的构建方法及其应用 |
Families Citing this family (31)
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US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
DE69942207D1 (de) * | 1998-08-25 | 2010-05-12 | Merck Patent Gmbh | Expression und export von angiostatin und endostatin als immunofusins |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (es) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
ES2311507T3 (es) | 2000-02-10 | 2009-02-16 | MASSACHUSETTS EYE & EAR INFIRMARY | Terapia fotodinamica para tratamiento de afecciones oftalmicas. |
ES2269366T3 (es) | 2000-02-11 | 2007-04-01 | Merck Patent Gmbh | Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos. |
DE60129695T2 (de) * | 2000-06-29 | 2008-06-05 | Merck Patent Gmbh | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
US6911204B2 (en) | 2000-08-11 | 2005-06-28 | Favrille, Inc. | Method and composition for altering a B cell mediated pathology |
CN1330664C (zh) | 2001-03-07 | 2007-08-08 | 默克专利有限公司 | 用于含杂合同种型抗体部分的蛋白质的表达技术 |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
CN100503639C (zh) | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
MXPA04005266A (es) | 2001-12-04 | 2004-10-11 | Merck Patent Gmbh | Inmunocitocinas con selectividad modulada. |
EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
WO2005063820A2 (en) * | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Il-7 fusion proteins |
DK1699821T3 (da) * | 2003-12-31 | 2012-07-16 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER |
CA2552590A1 (en) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
WO2005070967A2 (en) * | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
US7589179B2 (en) * | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
TW200732472A (en) * | 2005-10-21 | 2007-09-01 | Hoffmann La Roche | Method for the recombinant expression of a polypeptide |
PT2270050E (pt) | 2005-12-30 | 2013-09-12 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
ES2384055T3 (es) | 2005-12-30 | 2012-06-28 | Merck Patent Gmbh | Variantes de la interleucina-12p40 con estabilidad mejorada |
GB2441789B (en) * | 2006-09-18 | 2012-03-28 | Angus Buchan Gordon | Use of a Tumour Volume Measuring Device |
CA2759333A1 (en) | 2009-04-22 | 2010-10-28 | Merck Patent Gmbh | Antibody fusion proteins with modified fcrn binding sites |
EP2561888A1 (en) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protein comprising NC-1 for treating angiogenesis-related diseases |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
EP3675892A4 (en) | 2017-07-03 | 2021-10-06 | Torque Therapeutics, Inc. | IMMUNOSTIMULATORY FUSION MOLECULES AND THEIR USES |
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US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
CN100503639C (zh) * | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
MXPA04005266A (es) * | 2001-12-04 | 2004-10-11 | Merck Patent Gmbh | Inmunocitocinas con selectividad modulada. |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
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1999
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- 1999-04-15 DE DE69931908T patent/DE69931908T2/de not_active Expired - Lifetime
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104830901A (zh) * | 2015-01-21 | 2015-08-12 | 武汉友芝友生物制药有限公司 | 一种鼠肿瘤模型的构建方法及其应用 |
Also Published As
Publication number | Publication date |
---|---|
HUP0101352A2 (hu) | 2001-08-28 |
HK1038882A1 (zh) | 2002-04-04 |
DE69931908D1 (de) | 2006-07-27 |
NO20005155D0 (no) | 2000-10-13 |
WO1999052562A2 (en) | 1999-10-21 |
HUP0101352A3 (en) | 2003-08-28 |
CA2328076A1 (en) | 1999-10-21 |
US20040180035A1 (en) | 2004-09-16 |
AU3565099A (en) | 1999-11-01 |
EP1071468B1 (en) | 2006-06-14 |
ATE329622T1 (de) | 2006-07-15 |
WO1999052562A3 (en) | 1999-11-18 |
MXPA00010070A (es) | 2004-03-10 |
EP1071468A2 (en) | 2001-01-31 |
AU758860B2 (en) | 2003-04-03 |
RU2229305C2 (ru) | 2004-05-27 |
NO20005155L (no) | 2000-12-13 |
CA2328076C (en) | 2009-10-06 |
CN1318092C (zh) | 2007-05-30 |
PL343462A1 (en) | 2001-08-13 |
JP2002511432A (ja) | 2002-04-16 |
DE69931908T2 (de) | 2007-01-11 |
BR9909583A (pt) | 2002-01-15 |
ZA200005475B (en) | 2001-11-13 |
CZ20003767A3 (cs) | 2002-01-16 |
ES2267263T3 (es) | 2007-03-01 |
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