CN1303084C - 新型粗榧生物碱、其制备方法和其在治疗癌症、白血病、包括耐受通常的化学治疗剂的寄生物在内的寄生物及作为反向治疗剂的应用 - Google Patents

新型粗榧生物碱、其制备方法和其在治疗癌症、白血病、包括耐受通常的化学治疗剂的寄生物在内的寄生物及作为反向治疗剂的应用 Download PDF

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Publication number
CN1303084C
CN1303084C CNB00820036XA CN00820036A CN1303084C CN 1303084 C CN1303084 C CN 1303084C CN B00820036X A CNB00820036X A CN B00820036XA CN 00820036 A CN00820036 A CN 00820036A CN 1303084 C CN1303084 C CN 1303084C
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CN
China
Prior art keywords
dichloromethane
mmol
och
harringtonine
aqueous layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB00820036XA
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English (en)
Chinese (zh)
Other versions
CN1474821A (zh
Inventor
J-P·罗宾
R·达尔
F·德鲁耶
J－P·马里耶
N·拉多塞维克
J·罗宾
K·苏绍
P·巴塔伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemical Gene Pharmaceutical Co ltd
Ivax International Ltd
Teva Pharmaceuticals International GmbH
Original Assignee
Stijen Pharmaceutical
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Publication of CN1303084C publication Critical patent/CN1303084C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB00820036XA 2000-10-17 2000-10-17 新型粗榧生物碱、其制备方法和其在治疗癌症、白血病、包括耐受通常的化学治疗剂的寄生物在内的寄生物及作为反向治疗剂的应用 Expired - Fee Related CN1303084C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2000/001593 WO2002032904A1 (en) 2000-10-17 2000-10-17 New cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including thus resistant to usual chemotherapeutic agents and as reversal agents

Publications (2)

Publication Number Publication Date
CN1474821A CN1474821A (zh) 2004-02-11
CN1303084C true CN1303084C (zh) 2007-03-07

Family

ID=11003995

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB00820036XA Expired - Fee Related CN1303084C (zh) 2000-10-17 2000-10-17 新型粗榧生物碱、其制备方法和其在治疗癌症、白血病、包括耐受通常的化学治疗剂的寄生物在内的寄生物及作为反向治疗剂的应用

Country Status (12)

Country Link
US (1) US6579869B1 (https=)
EP (1) EP1328527B1 (https=)
JP (1) JP4837233B2 (https=)
CN (1) CN1303084C (https=)
AT (1) ATE319714T1 (https=)
AU (1) AU7940500A (https=)
CA (1) CA2426103A1 (https=)
DE (1) DE60026557T2 (https=)
DK (1) DK1328527T3 (https=)
ES (1) ES2258024T3 (https=)
PT (1) PT1328527E (https=)
WO (1) WO2002032904A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285546B2 (en) * 2000-10-17 2007-10-23 Stragen Pharma S.A. Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents
US20020128258A1 (en) * 2001-03-09 2002-09-12 Jean-Pierre Robin Therapeutical method involving subcutaneous administration of drugs containing cephalotaxine derivatives
US20040082565A1 (en) * 2002-07-17 2004-04-29 Chemgenex Therapeutics, Inc. Formulations and methods of administration of cephalotaxines including homoharringtonine
WO2004009030A2 (en) * 2002-07-22 2004-01-29 Chemgenex Pharmaceuticals Limited Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof
US8466142B2 (en) 2008-03-03 2013-06-18 Sloan-Kettering Institute For Cancer Research Cephalotaxus esters, methods of synthesis, and uses thereof
WO2010103405A2 (en) * 2009-03-11 2010-09-16 Jean-Pierre Robin Process for preparing cephalotaxine esters
CN102304132B (zh) * 2011-07-12 2015-01-28 南开大学 高效高立体选择性半合成三尖杉酯类生物碱的方法
CN103687859B (zh) * 2011-08-18 2016-08-17 杭州本生药业有限公司 高三尖杉酯碱的胺化衍生物、及其制备方法和应用
EP2746286A4 (en) * 2011-08-18 2015-01-07 Hangzhou Bensheng Pharmaceutical Co Ltd HOMOHARRINGTONIN AMINO DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
CN102675327B (zh) * 2012-03-01 2014-12-10 南开大学 三尖杉酯碱类似物及制备方法和应用
CN104293855A (zh) * 2014-10-15 2015-01-21 中国计量学院 脐孢木霉菌转化株在提高木霉素产量中的应用
WO2016182850A1 (en) 2015-05-08 2016-11-17 Albany Molecular Research, Inc. Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
CN106866690B (zh) * 2015-12-10 2019-10-11 南开大学 三尖杉酯类生物碱、其制备方法和用途
CN109111459B (zh) * 2017-06-22 2021-10-29 南华大学 含水杨酸三尖杉碱酯衍生物、制造方法及其用途
CN108378049A (zh) * 2018-05-02 2018-08-10 孙利嫚 一种含有粗榧生物碱和甲氧虫酰肼的农药组合物
WO2024061357A1 (zh) * 2022-09-22 2024-03-28 南开大学 三尖杉酯碱类衍生物及其药物组合物、制备方法和用途
KR20250160078A (ko) * 2024-05-03 2025-11-11 주식회사 아론티어 암 연관 섬유아세포 표적용 약학 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048894A1 (en) * 1998-03-20 1999-09-30 Oncopharm Corporation Novel cephalotaxane derivatives and process for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048894A1 (en) * 1998-03-20 1999-09-30 Oncopharm Corporation Novel cephalotaxane derivatives and process for their preparation

Also Published As

Publication number Publication date
DK1328527T3 (da) 2006-07-17
DE60026557D1 (de) 2006-05-04
US6579869B1 (en) 2003-06-17
JP4837233B2 (ja) 2011-12-14
EP1328527B1 (en) 2006-03-08
PT1328527E (pt) 2006-06-30
EP1328527A1 (en) 2003-07-23
JP2004511560A (ja) 2004-04-15
WO2002032904A1 (en) 2002-04-25
CN1474821A (zh) 2004-02-11
DE60026557T2 (de) 2006-12-28
CA2426103A1 (en) 2002-04-25
AU7940500A (en) 2002-04-29
ES2258024T3 (es) 2006-08-16
ATE319714T1 (de) 2006-03-15
HK1063183A1 (en) 2004-12-17

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