CN1300210A - 作为抗菌剂的异羟肟酸衍生物 - Google Patents

作为抗菌剂的异羟肟酸衍生物 Download PDF

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Publication number
CN1300210A
CN1300210A CN99806057A CN99806057A CN1300210A CN 1300210 A CN1300210 A CN 1300210A CN 99806057 A CN99806057 A CN 99806057A CN 99806057 A CN99806057 A CN 99806057A CN 1300210 A CN1300210 A CN 1300210A
Authority
CN
China
Prior art keywords
alkyl
hydrogen
phenyl
group
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99806057A
Other languages
English (en)
Chinese (zh)
Inventor
M·G·亨特
R·P·贝克特
J·M·克莱门茨
M·惠特克
Z·M·斯帕沃尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of CN1300210A publication Critical patent/CN1300210A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN99806057A 1998-05-16 1999-05-14 作为抗菌剂的异羟肟酸衍生物 Pending CN1300210A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810464.9A GB9810464D0 (en) 1998-05-16 1998-05-16 Hydroxamic acid derivatives
GB9810464.9 1998-05-16

Publications (1)

Publication Number Publication Date
CN1300210A true CN1300210A (zh) 2001-06-20

Family

ID=10832125

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99806057A Pending CN1300210A (zh) 1998-05-16 1999-05-14 作为抗菌剂的异羟肟酸衍生物

Country Status (23)

Country Link
US (3) US6441042B1 (https=)
EP (2) EP1079819B1 (https=)
JP (1) JP2002515427A (https=)
KR (1) KR100634089B1 (https=)
CN (1) CN1300210A (https=)
AT (1) ATE347356T1 (https=)
AU (1) AU754063B2 (https=)
BR (1) BR9910488A (https=)
CA (1) CA2332713C (https=)
CY (1) CY1106452T1 (https=)
DE (1) DE69934309T2 (https=)
DK (1) DK1079819T3 (https=)
ES (1) ES2278444T3 (https=)
GB (2) GB9810464D0 (https=)
HU (1) HUP0102290A3 (https=)
IL (2) IL139059A0 (https=)
NO (1) NO20005782L (https=)
NZ (1) NZ507560A (https=)
PL (1) PL344438A1 (https=)
PT (1) PT1079819E (https=)
TR (1) TR200003376T2 (https=)
WO (1) WO1999059568A1 (https=)
ZA (1) ZA200006131B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用

Families Citing this family (20)

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GB2349884A (en) * 1998-02-07 2000-11-15 British Biotech Pharm Antibacterial agents
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
US6908911B1 (en) * 1999-08-10 2005-06-21 British Biotech Pharmaceuticals Limited Antibacterial agents
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
EP1237862A1 (en) * 1999-12-17 2002-09-11 Versicor, Inc. Succinate compounds, compositions and methods of use and preparation
AU2002230385A1 (en) * 2000-09-25 2002-04-15 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
WO2002041886A1 (en) * 2000-11-23 2002-05-30 British Biotech Pharmaceuticals Ltd Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
EP1372692A4 (en) * 2001-03-19 2005-10-26 Sloan Kettering Inst Cancer ASYMMETRIC SYNTHESIS OF (S, S, R) - (-) - ACTINONE AND ITS ANALOG AND USES THEREOF
US20040267015A1 (en) * 2001-04-05 2004-12-30 Ajita Bhat Peptide deformylase inhibitors
GB0128943D0 (en) * 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
JP4190862B2 (ja) * 2001-12-18 2008-12-03 シャープ株式会社 表示装置およびその駆動方法
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
US8993641B2 (en) * 2007-11-29 2015-03-31 Innolex Investment Corporation Preservation of cosmetics, toiletry and pharmaceutical compositions
DE102011088962A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
US10829440B2 (en) 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
US11653649B2 (en) 2017-06-29 2023-05-23 Kimberly-Clark Worldwide, Inc. Antimicrobial composition including a dihydroxamic acid and methods of inhibiting microbial growth utilizing the same
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

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GB1028921A (en) * 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
FI960803A7 (fi) 1993-08-23 1996-04-22 Immunex Corp TNF-alfa-sekreetion inhibiittoreita
JP3157372B2 (ja) 1993-11-29 2001-04-16 三洋電機株式会社 フィルタ
JPH10501806A (ja) * 1994-06-22 1998-02-17 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
US5532265A (en) 1994-11-30 1996-07-02 The Board Of Trustees Of The Leland Stanford Junior University Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
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GB2349884A (en) * 1998-02-07 2000-11-15 British Biotech Pharm Antibacterial agents
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用

Also Published As

Publication number Publication date
EP1754477A2 (en) 2007-02-21
EP1754477A3 (en) 2007-03-14
NZ507560A (en) 2003-06-30
AU754063B2 (en) 2002-10-31
PL344438A1 (en) 2001-11-05
JP2002515427A (ja) 2002-05-28
IL139059A0 (en) 2001-11-25
NO20005782D0 (no) 2000-11-15
AU3942199A (en) 1999-12-06
GB9810464D0 (en) 1998-07-15
WO1999059568A1 (en) 1999-11-25
DE69934309T2 (de) 2007-07-05
US20060211732A1 (en) 2006-09-21
NO20005782L (no) 2001-01-15
IL139059A (en) 2006-12-31
GB2353708A (en) 2001-03-07
BR9910488A (pt) 2001-01-09
DE69934309D1 (de) 2007-01-18
US20020198241A1 (en) 2002-12-26
PT1079819E (pt) 2007-03-30
CY1106452T1 (el) 2011-10-12
EP1079819B1 (en) 2006-12-06
US6992190B2 (en) 2006-01-31
EP1079819A1 (en) 2001-03-07
HUP0102290A2 (hu) 2001-11-28
KR100634089B1 (ko) 2006-10-17
GB0024789D0 (en) 2000-11-22
CA2332713C (en) 2008-04-01
TR200003376T2 (tr) 2001-03-21
ES2278444T3 (es) 2007-08-01
US7323563B2 (en) 2008-01-29
CA2332713A1 (en) 1999-11-25
ZA200006131B (en) 2002-01-30
ATE347356T1 (de) 2006-12-15
HUP0102290A3 (en) 2001-12-28
US6441042B1 (en) 2002-08-27
DK1079819T3 (da) 2007-04-10
KR20010034861A (ko) 2001-04-25

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication