ES2278444T3 - Derivados del acido hidroxamico como antibacterianos. - Google Patents

Derivados del acido hidroxamico como antibacterianos. Download PDF

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Publication number
ES2278444T3
ES2278444T3 ES99922317T ES99922317T ES2278444T3 ES 2278444 T3 ES2278444 T3 ES 2278444T3 ES 99922317 T ES99922317 T ES 99922317T ES 99922317 T ES99922317 T ES 99922317T ES 2278444 T3 ES2278444 T3 ES 2278444T3
Authority
ES
Spain
Prior art keywords
alkyl
group
amino
cycloalkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99922317T
Other languages
English (en)
Spanish (es)
Inventor
Michael George British Biotech Hunter
Raymond Paul British Biotech BECKETT
John Martin British Biotech CLEMENTS
Mark British Biotech WHITTAKER
Zoe Marie British Biotech SPAVOLD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Application granted granted Critical
Publication of ES2278444T3 publication Critical patent/ES2278444T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ES99922317T 1998-05-16 1999-05-14 Derivados del acido hidroxamico como antibacterianos. Expired - Lifetime ES2278444T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810464.9A GB9810464D0 (en) 1998-05-16 1998-05-16 Hydroxamic acid derivatives
GB9810464 1998-05-16

Publications (1)

Publication Number Publication Date
ES2278444T3 true ES2278444T3 (es) 2007-08-01

Family

ID=10832125

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99922317T Expired - Lifetime ES2278444T3 (es) 1998-05-16 1999-05-14 Derivados del acido hidroxamico como antibacterianos.

Country Status (23)

Country Link
US (3) US6441042B1 (https=)
EP (2) EP1079819B1 (https=)
JP (1) JP2002515427A (https=)
KR (1) KR100634089B1 (https=)
CN (1) CN1300210A (https=)
AT (1) ATE347356T1 (https=)
AU (1) AU754063B2 (https=)
BR (1) BR9910488A (https=)
CA (1) CA2332713C (https=)
CY (1) CY1106452T1 (https=)
DE (1) DE69934309T2 (https=)
DK (1) DK1079819T3 (https=)
ES (1) ES2278444T3 (https=)
GB (2) GB9810464D0 (https=)
HU (1) HUP0102290A3 (https=)
IL (2) IL139059A0 (https=)
NO (1) NO20005782L (https=)
NZ (1) NZ507560A (https=)
PL (1) PL344438A1 (https=)
PT (1) PT1079819E (https=)
TR (1) TR200003376T2 (https=)
WO (1) WO1999059568A1 (https=)
ZA (1) ZA200006131B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2349884A (en) * 1998-02-07 2000-11-15 British Biotech Pharm Antibacterial agents
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
US6908911B1 (en) * 1999-08-10 2005-06-21 British Biotech Pharmaceuticals Limited Antibacterial agents
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
EP1237862A1 (en) * 1999-12-17 2002-09-11 Versicor, Inc. Succinate compounds, compositions and methods of use and preparation
AU2002230385A1 (en) * 2000-09-25 2002-04-15 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
WO2002041886A1 (en) * 2000-11-23 2002-05-30 British Biotech Pharmaceuticals Ltd Ydroxamic acid or n-formyl hydroxylamine derivatives as inhibitors of bakterial polypeptide deformylase for treating microbial infections
EP1372692A4 (en) * 2001-03-19 2005-10-26 Sloan Kettering Inst Cancer ASYMMETRIC SYNTHESIS OF (S, S, R) - (-) - ACTINONE AND ITS ANALOG AND USES THEREOF
US20040267015A1 (en) * 2001-04-05 2004-12-30 Ajita Bhat Peptide deformylase inhibitors
GB0128943D0 (en) * 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
JP4190862B2 (ja) * 2001-12-18 2008-12-03 シャープ株式会社 表示装置およびその駆動方法
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
US8993641B2 (en) * 2007-11-29 2015-03-31 Innolex Investment Corporation Preservation of cosmetics, toiletry and pharmaceutical compositions
DE102011088962A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
US10829440B2 (en) 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
US11653649B2 (en) 2017-06-29 2023-05-23 Kimberly-Clark Worldwide, Inc. Antimicrobial composition including a dihydroxamic acid and methods of inhibiting microbial growth utilizing the same
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028921A (en) * 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
FI960803A7 (fi) 1993-08-23 1996-04-22 Immunex Corp TNF-alfa-sekreetion inhibiittoreita
JP3157372B2 (ja) 1993-11-29 2001-04-16 三洋電機株式会社 フィルタ
JPH10501806A (ja) * 1994-06-22 1998-02-17 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
US5532265A (en) 1994-11-30 1996-07-02 The Board Of Trustees Of The Leland Stanford Junior University Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AU5187698A (en) * 1996-12-06 1998-06-29 Cancerforskningsfondet Af 1989 Inhibition of invasive remodelling
ZA9711121B (en) * 1996-12-13 1998-06-23 Handelman Joseph H Reduction of hair growth.
GB2349884A (en) * 1998-02-07 2000-11-15 British Biotech Pharm Antibacterial agents
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives

Also Published As

Publication number Publication date
EP1754477A2 (en) 2007-02-21
EP1754477A3 (en) 2007-03-14
NZ507560A (en) 2003-06-30
AU754063B2 (en) 2002-10-31
PL344438A1 (en) 2001-11-05
JP2002515427A (ja) 2002-05-28
IL139059A0 (en) 2001-11-25
NO20005782D0 (no) 2000-11-15
AU3942199A (en) 1999-12-06
GB9810464D0 (en) 1998-07-15
WO1999059568A1 (en) 1999-11-25
DE69934309T2 (de) 2007-07-05
US20060211732A1 (en) 2006-09-21
NO20005782L (no) 2001-01-15
IL139059A (en) 2006-12-31
GB2353708A (en) 2001-03-07
BR9910488A (pt) 2001-01-09
DE69934309D1 (de) 2007-01-18
US20020198241A1 (en) 2002-12-26
PT1079819E (pt) 2007-03-30
CY1106452T1 (el) 2011-10-12
EP1079819B1 (en) 2006-12-06
US6992190B2 (en) 2006-01-31
EP1079819A1 (en) 2001-03-07
HUP0102290A2 (hu) 2001-11-28
KR100634089B1 (ko) 2006-10-17
CN1300210A (zh) 2001-06-20
GB0024789D0 (en) 2000-11-22
CA2332713C (en) 2008-04-01
TR200003376T2 (tr) 2001-03-21
US7323563B2 (en) 2008-01-29
CA2332713A1 (en) 1999-11-25
ZA200006131B (en) 2002-01-30
ATE347356T1 (de) 2006-12-15
HUP0102290A3 (en) 2001-12-28
US6441042B1 (en) 2002-08-27
DK1079819T3 (da) 2007-04-10
KR20010034861A (ko) 2001-04-25

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