CN1289248A - 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法 - Google Patents

治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法 Download PDF

Info

Publication number
CN1289248A
CN1289248A CN99802500A CN99802500A CN1289248A CN 1289248 A CN1289248 A CN 1289248A CN 99802500 A CN99802500 A CN 99802500A CN 99802500 A CN99802500 A CN 99802500A CN 1289248 A CN1289248 A CN 1289248A
Authority
CN
China
Prior art keywords
chemical compound
group
alkyl
methyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99802500A
Other languages
English (en)
Chinese (zh)
Inventor
T·J·尼茨
D·C·佩维尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viropharma Biologics LLC
Original Assignee
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc filed Critical Viropharma Inc
Publication of CN1289248A publication Critical patent/CN1289248A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN99802500A 1998-01-29 1999-01-29 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法 Pending CN1289248A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7303898P 1998-01-29 1998-01-29
US60/073,038 1998-01-29
US7307898P 1998-01-30 1998-01-30
US60/073,078 1998-01-30

Publications (1)

Publication Number Publication Date
CN1289248A true CN1289248A (zh) 2001-03-28

Family

ID=26754055

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99802500A Pending CN1289248A (zh) 1998-01-29 1999-01-29 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法

Country Status (9)

Country Link
EP (1) EP1051169A4 (fr)
JP (1) JP2002501894A (fr)
CN (1) CN1289248A (fr)
AU (1) AU759772B2 (fr)
BR (1) BR9908522A (fr)
CA (1) CA2319465C (fr)
MX (1) MXPA00007394A (fr)
NZ (1) NZ505894A (fr)
WO (1) WO1999038508A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104507918A (zh) * 2012-06-29 2015-04-08 微剂量治疗公司 用于治疗或预防肺炎病毒感染和相关疾病的组合物和方法
CN114390929A (zh) * 2019-06-13 2022-04-22 奇达拉治疗公司 用于治疗呼吸道合胞病毒的组合物及方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
EP2428226A1 (fr) 2001-10-22 2012-03-14 The Scripps Research Institute Composés de ciblage d'anticorps
US8119672B2 (en) * 2002-08-09 2012-02-21 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US8202896B2 (en) * 2002-08-09 2012-06-19 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
JP4537407B2 (ja) 2003-10-30 2010-09-01 ベーリンガー インゲルハイム （カナダ） リミテッド Ｒｓｖポリメラーゼインヒビター
KR101164258B1 (ko) 2003-12-23 2012-07-11 아스텍스 테라퓨틱스 리미티드 단백질 키나아제 조절제로서의 피라졸 유도체
EP1902032A1 (fr) 2005-06-22 2008-03-26 Astex Therapeutics Limited Composes pharmaceutiques
US8541461B2 (en) 2005-06-23 2013-09-24 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
EP2395992A2 (fr) 2009-02-10 2011-12-21 The Scripps Research Institute Vaccination programmée chimiquement
EP3081569B1 (fr) 2013-12-10 2019-09-18 Shandong Danhong Pharmaceutical Co., Ltd. Dérivé d'imidazole utilisé en tant qu'agent antiviral et son utilisation pour la préparation d'un médicament
EP3305790B1 (fr) 2015-06-08 2020-08-05 Shangdong Danhong Pharmaceutical Co., Ltd. Procédé de préparation d'un dérivé d'imidazole et d'un intermédiaire de celui-ci et sa forme cristalline

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508391A (en) * 1975-01-20 1978-04-26 Sterling Drug Inc Phenylalkylamines
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US5098920A (en) * 1990-05-04 1992-03-24 G. D. Searle & Co. 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
WO1995000131A1 (fr) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Ligands du recepteur sigma et leur utilisation
US6124280A (en) * 1995-07-27 2000-09-26 Warner-Lambert Company Substituted phenols as novel calcium channel blockers
CN1163401A (zh) * 1996-02-13 1997-10-29 李占元 全自动血球计数仪试剂及配制方法
CA2250464A1 (fr) * 1996-03-29 1997-10-09 G.D. Searle & Co. Derives de phenylene meta-substitues, utilises comme antagonistes ou inhibiteurs de l'integrine alphavbeta3

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104507918A (zh) * 2012-06-29 2015-04-08 微剂量治疗公司 用于治疗或预防肺炎病毒感染和相关疾病的组合物和方法
US9504672B2 (en) 2012-06-29 2016-11-29 Microdose Therapeutx, Inc. Compositions and methods for treating or preventing pneumovirus infection and associated diseases
CN114390929A (zh) * 2019-06-13 2022-04-22 奇达拉治疗公司 用于治疗呼吸道合胞病毒的组合物及方法

Also Published As

Publication number Publication date
CA2319465A1 (fr) 1999-08-05
JP2002501894A (ja) 2002-01-22
BR9908522A (pt) 2001-10-02
AU759772B2 (en) 2003-05-01
CA2319465C (fr) 2013-03-19
WO1999038508A1 (fr) 1999-08-05
EP1051169A4 (fr) 2002-05-29
MXPA00007394A (es) 2003-08-01
EP1051169A1 (fr) 2000-11-15
NZ505894A (en) 2002-12-20

Similar Documents

Publication Publication Date Title
CN1134439C (zh) 吡咯并[2,3d]嘧啶类化合物及它们作为酪氨酸激酶抑制剂的用途
JP6506836B2 (ja) Ｂ型肝炎ウイルス感染症の処置および予防のための新規ピリダゾンおよびトリアジノン
CN1289248A (zh) 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法
TW450961B (en) Substituted N-(indole-2-carbonyl)-β-alanimamides and derivatives as antidiabetic agents
CN1023700C (zh) 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备
CN1215060C (zh) 稠合的吡唑基化合物、包含该化合物的组合物及该化合物的应用
CN101835763A (zh) *二唑烷二酮化合物
CN1731994A (zh) 预防或治疗神经病的药剂
CN1922181A (zh) 通过使用咪唑并[1,2－b]哒嗪衍生物控制动物中的寄生虫
CN1176101A (zh) N－(4－芳基－噻唑－2－基)－磺胺衍生物及其用途
CN1063491A (zh) 1，4-苯并硫杂吖庚因衍生物
CN108602786B (zh) 一种取代的噁二唑类化合物及包含该化合物的组合物及其用途
KR20070007759A (ko) 바이러스 복제 억제제로서 유용한 치환된 아릴티오우레아유도체
CN1528742A (zh) 治疗哮喘、过敏和炎症的化合物及其中间体
CN1212255A (zh) 联苯磺酰基氨基氰、其制备方法及其作为药物的用途
CN1166833A (zh) 嘧啶基吡唑衍生物
CN1065062A (zh) 用作白三烯拮抗剂的含喹啉酮酸
CN1216547A (zh) 质子泵抑制剂
CN1103402A (zh) 取代的吡咯类化合物
CN1649591A (zh) 可用作hiv逆转录酶抑制剂的三环化合物
CN1214677A (zh) 作为环氧化酶－2抑制剂药物前体的二苯基1,2－二苯乙烯类化合物
CN1212683A (zh) 具有抗病毒活性的2－氨基－5,6－二氯苯并咪唑衍生物
CN1107843A (zh) 二氢化茚衍生物和其制法及合成该衍生物的中间体
CN1244799A (zh) L－β－二氧戊环尿苷类似物和治疗和预防病毒感染的方法
CN1021050C (zh) 丁烯酰胺衍生物的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication