CN1278260A - 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 - Google Patents

氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 Download PDF

Info

Publication number
CN1278260A
CN1278260A CN98810769A CN98810769A CN1278260A CN 1278260 A CN1278260 A CN 1278260A CN 98810769 A CN98810769 A CN 98810769A CN 98810769 A CN98810769 A CN 98810769A CN 1278260 A CN1278260 A CN 1278260A
Authority
CN
China
Prior art keywords
methyl
hydrogen
benzo
quinolizinyl
methoxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98810769A
Other languages
English (en)
Chinese (zh)
Inventor
P·梅耶
J－L·维达鲁克
T·伊姆伯特
M·马瑞恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of CN1278260A publication Critical patent/CN1278260A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN98810769A 1997-10-28 1998-10-26 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 Pending CN1278260A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9713499A FR2770215B1 (fr) 1997-10-28 1997-10-28 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives
FR97/13499 1997-10-28

Publications (1)

Publication Number Publication Date
CN1278260A true CN1278260A (zh) 2000-12-27

Family

ID=9512729

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98810769A Pending CN1278260A (zh) 1997-10-28 1998-10-26 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用

Country Status (8)

Country Link
EP (1) EP1027350A1 (ja)
JP (1) JP2001521034A (ja)
CN (1) CN1278260A (ja)
AU (1) AU9751798A (ja)
BR (1) BR9813303A (ja)
CA (1) CA2307748A1 (ja)
FR (1) FR2770215B1 (ja)
WO (1) WO1999021856A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
WO2006054793A1 (ja) * 2004-11-19 2006-05-26 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
AU2007248764B2 (en) * 2006-05-02 2013-08-01 Avid Radiopharmaceuticals, Inc. Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
FR2976287B1 (fr) 2011-06-09 2013-07-05 Pf Medicament Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique
EP3330269B1 (en) * 2011-09-19 2023-06-07 Kumar, Ajay Heterocyclic compounds as inhibitors of fatty acid biosynthesis for bacterial infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416432D0 (en) * 1984-06-28 1984-08-01 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
BR9813303A (pt) 2000-08-29
FR2770215A1 (fr) 1999-04-30
WO1999021856A1 (fr) 1999-05-06
JP2001521034A (ja) 2001-11-06
FR2770215B1 (fr) 2000-01-14
CA2307748A1 (fr) 1999-05-06
EP1027350A1 (fr) 2000-08-16
AU9751798A (en) 1999-05-17

Similar Documents

Publication Publication Date Title
CN1064356C (zh) 新哌嗪、哌啶与1,2,5,6－四氢吡啶化合物，其制法及其药物组合物
CN1052006C (zh) 血管收缩剂二氢苯并吡喃衍生物,制备方法和用途
CN1118598A (zh) 吡咯并吡啶衍生物
CN1205699A (zh) 1－(1,2－双取代哌啶基)－4－取代哌嗪衍生物
CN1143953A (zh) 某些稠合n-吡咯甲酰苯胺；一类新的脑gaba受体配体
CN1759093A (zh) 用于制备1,2－二氨基化合物的不使用叠氮化物的方法
CN1031619C (zh) 噁唑烷酮衍生物用于制备药物
CN1105360A (zh) 1-[2h-1-苯并吡喃-2-酮-8-基]-哌嗪衍生物
FR2681325A1 (fr) Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
CN1278260A (zh) 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用
CN1153766C (zh) 新的硝酮化合物，其制备方法以及含有它们的药物组合物
CN1256337C (zh) 抗抑郁的7,8－二氢－1,6,9－三氧杂－3－氮杂－环戊二烯并[a]萘的氮杂环基甲基衍生物
CN1267434C (zh) 抗抑郁的(SSSRI)7,8－二氢－3H－6,9－二氧杂－1,3－二氮杂环戊二烯并[a]萘的氮杂环基甲基衍生物
CN1103402A (zh) 取代的吡咯类化合物
CN1503798A (zh) 抗抑郁的氧杂环稠合的－[1,4]苯并二噁烷的氮杂环基甲基衍生物
CN1306510A (zh) 光学活性四氢苯并吲哚衍生物
CN1066723C (zh) Hiv蛋白酶抑制剂的中间体及其制备方法
CN1069491A (zh) 2-(哌啶-1-基)乙醇衍生物，其制法及其治疗应用
CN1100759C (zh) 呫吨和吖啶衍生物及其用途
CN1031403C (zh) 羟基烷基呋喃基衍生物的制备方法
FR2689509A1 (fr) Nouveaux dérivés spiraniques du 3-amino chromane, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
CN1503801A (zh) 抗抑郁的2,3－二氢－1,4－二噁英并[2,3－f]喹喔啉的氮杂环基甲基衍生物
CN1130905A (zh) Hiv蛋白酶抑制剂的制备方法
FR2791675A1 (fr) Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique
CN1235897C (zh) 具有抗肿瘤活性的4－β－胺基－类糖侧链－4－脱氧－4’－去甲表鬼臼毒素衍生物及其合成方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication