CA2307748A1 - Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives - Google Patents

Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives Download PDF

Info

Publication number
CA2307748A1
CA2307748A1 CA002307748A CA2307748A CA2307748A1 CA 2307748 A1 CA2307748 A1 CA 2307748A1 CA 002307748 A CA002307748 A CA 002307748A CA 2307748 A CA2307748 A CA 2307748A CA 2307748 A1 CA2307748 A1 CA 2307748A1
Authority
CA
Canada
Prior art keywords
hexahydro
methoxy
methyl
benzo
quinolizinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002307748A
Other languages
English (en)
French (fr)
Inventor
Patrice Mayer
Jean-Louis Vidaluc
Thierry Imbert
Marc Marien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2307748A1 publication Critical patent/CA2307748A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002307748A 1997-10-28 1998-10-26 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives Abandoned CA2307748A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9713499A FR2770215B1 (fr) 1997-10-28 1997-10-28 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives
FR97/13499 1997-10-28
PCT/FR1998/002281 WO1999021856A1 (fr) 1997-10-28 1998-10-26 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives

Publications (1)

Publication Number Publication Date
CA2307748A1 true CA2307748A1 (fr) 1999-05-06

Family

ID=9512729

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002307748A Abandoned CA2307748A1 (fr) 1997-10-28 1998-10-26 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives

Country Status (8)

Country Link
EP (1) EP1027350A1 (ja)
JP (1) JP2001521034A (ja)
CN (1) CN1278260A (ja)
AU (1) AU9751798A (ja)
BR (1) BR9813303A (ja)
CA (1) CA2307748A1 (ja)
FR (1) FR2770215B1 (ja)
WO (1) WO1999021856A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
WO2006054793A1 (ja) * 2004-11-19 2006-05-26 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
CA2650904C (en) * 2006-05-02 2015-07-07 The Trustees Of The University Of Pennsylvania Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
FR2976287B1 (fr) 2011-06-09 2013-07-05 Pf Medicament Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique
EP2758376A4 (en) * 2011-09-19 2015-04-29 Vitas Pharma Res Private Ltd HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYNTHESIS FOR BACTERIAL INFECTIONS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416432D0 (en) * 1984-06-28 1984-08-01 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
AU9751798A (en) 1999-05-17
EP1027350A1 (fr) 2000-08-16
WO1999021856A1 (fr) 1999-05-06
FR2770215B1 (fr) 2000-01-14
FR2770215A1 (fr) 1999-04-30
BR9813303A (pt) 2000-08-29
CN1278260A (zh) 2000-12-27
JP2001521034A (ja) 2001-11-06

Similar Documents

Publication Publication Date Title
JP6717457B2 (ja) Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体
EP0591040B1 (fr) Amides basiques quaternaires comme antagonistes des tachykinines
KR100228813B1 (ko) 티아졸의 분지쇄 알킬아미노유도체, 그의 제조방법 및 그를 함유하는 약제학적 조성물
EP0867436B1 (fr) Dérivés de N-aryl pipéridine et leur utilisation comme ligands du récepteur 5-HT1B
JP2008509897A (ja) エナンチオ選択的製造方法
CA2694377A1 (fr) Derives d'imidazolones, procede de preparation et applications biologiques
JPS6327471A (ja) 光学活性なベンゼンスルホンアミド誘導体の製造法
CN106660949B (zh) N-[4-(1-氨基乙基)-苯基]-磺酰胺衍生物的手性拆分方法
EP0662471A2 (fr) Dérivés naphtaléniques ayant une affinité pour les récepteurs de la mélatonine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2014049133A1 (en) New positive allosteric modulators of nicotinic acetylcholine receptor
JP2019501923A (ja) 極性非プロトン性溶媒を用いたｎ−［４−（１−アミノエチル）−フェニル］−スルホンアミド誘導体のキラル分割方法
CA2307748A1 (fr) Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives
KR102537616B1 (ko) 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
RU2125561C1 (ru) Промежуточные соединения для синтеза ингибиторов вич-протеаз и способы их получения
CA2308867C (fr) Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK2729447T3 (en) POSITIVE ALLOSTERIC MODULATORS OF NICOTIN ACETYL CHOLINE RECEPTOR
WO2022104599A1 (zh) 氮杂环卡宾催化剂及其制备方法
JP2000327659A (ja) 光学活性ピリジルアルコール類の製造方法
FR3100246A1 (fr) Procede de preparation du sel sodique d'elagolix et intermediaires dudit procede
Bluke et al. Evaluation of an enantioselective synthesis of 6-chloro-3, 4-dihydro-2 H-1, 2-benzothiazine-3-carboxylic acid 1, 1-dioxide and its derivatives
JP2022126890A (ja) フルオロアルキル基含有化合物とその製造方法
KR101057304B1 (ko) 키랄 촉매를 이용한 아스파르트산 유도체의 제조방법
WO2007012761A1 (fr) Nouveaux composes 1,1-pyridinyl aminocyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2438828A1 (fr) Derives d'arylcarbamates, preparation et utilisations
KR100395779B1 (ko) 임의적으로 베타-위치가 치환된 알파-아릴알킬기의 제거를통해 3급 아미드 화합물로부터 2급 아미드 화합물을제조하는 방법

Legal Events

Date Code Title Description
FZDE Dead