CN1272105A - 含六元环的化合物,其制备方法及其作为药物的用途 - Google Patents

含六元环的化合物,其制备方法及其作为药物的用途 Download PDF

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Publication number
CN1272105A
CN1272105A CN98809320A CN98809320A CN1272105A CN 1272105 A CN1272105 A CN 1272105A CN 98809320 A CN98809320 A CN 98809320A CN 98809320 A CN98809320 A CN 98809320A CN 1272105 A CN1272105 A CN 1272105A
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independently
compound
acid
alkyl
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Chinese (zh)
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N·W·比邵夫伯格
T·C·达尔
M·J·M·黑驰考克
C·U·基姆
W·卢
刘洪涛
R·G·米尔斯
M·A·威廉姆斯
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Gilead Sciences Inc
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Gilead Sciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN98809320A 1997-09-17 1998-09-15 含六元环的化合物,其制备方法及其作为药物的用途 Pending CN1272105A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US60/059,308 1997-09-17
US6019597P 1997-09-26 1997-09-26
US93864497A 1997-09-26 1997-09-26
US08/938,644 1997-09-26
US60/060,195 1997-09-26

Publications (1)

Publication Number Publication Date
CN1272105A true CN1272105A (zh) 2000-11-01

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CN98809320A Pending CN1272105A (zh) 1997-09-17 1998-09-15 含六元环的化合物,其制备方法及其作为药物的用途

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Country Link
EP (1) EP1015417A1 (enExample)
JP (1) JP2001516739A (enExample)
KR (1) KR20010024123A (enExample)
CN (1) CN1272105A (enExample)
AR (1) AR013960A1 (enExample)
AU (1) AU747702B2 (enExample)
BR (1) BR9812649A (enExample)
CA (1) CA2303323A1 (enExample)
EA (1) EA003989B1 (enExample)
ID (1) ID25516A (enExample)
IL (1) IL134691A0 (enExample)
IN (1) IN190983B (enExample)
NZ (1) NZ502988A (enExample)
TR (1) TR200000723T2 (enExample)
WO (1) WO1999014185A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659615A (zh) * 2012-05-09 2012-09-12 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
CN108047076A (zh) * 2017-12-26 2018-05-18 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728A (zh) * 2019-06-19 2019-09-03 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
WO2022022448A1 (zh) * 2020-07-29 2022-02-03 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN116666669A (zh) * 2023-07-25 2023-08-29 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途
CN117105801A (zh) * 2023-07-24 2023-11-24 四川青木制药有限公司 一种奥司他韦及其磷酸盐的制备方法及其中间体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1040094T1 (sl) * 1997-12-17 2009-10-31 Biocryst Pharm Inc Substituirane ciklopentanske in ciklopentenske spojine, uporabne kot inhibitorji nevraminidaze
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
DK1059283T3 (da) * 1999-06-11 2003-09-15 Hoffmann La Roche Fremgangsmåde til fremstilling af neuraminidase-inhibitor ro-64-0796
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
AU7608100A (en) * 1999-10-19 2001-04-30 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
WO2001080892A1 (en) * 2000-04-25 2001-11-01 Sankyo Company, Limited Preventives for influenza
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
CA2633538A1 (en) 2005-12-28 2007-07-05 F. Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
EP2499201B1 (en) * 2009-11-11 2017-05-10 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282950B6 (sk) * 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
CN100409844C (zh) * 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
NZ507106A (en) * 1996-08-23 2003-01-31 Gilead Sciences Inc Preparation of cyclohexene carboxylate derivatives

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102659615A (zh) * 2012-05-09 2012-09-12 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
CN108047076A (zh) * 2017-12-26 2018-05-18 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728A (zh) * 2019-06-19 2019-09-03 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
WO2022022448A1 (zh) * 2020-07-29 2022-02-03 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN117105801A (zh) * 2023-07-24 2023-11-24 四川青木制药有限公司 一种奥司他韦及其磷酸盐的制备方法及其中间体
CN116666669A (zh) * 2023-07-25 2023-08-29 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途

Also Published As

Publication number Publication date
AU9569498A (en) 1999-04-05
CA2303323A1 (en) 1999-03-25
JP2001516739A (ja) 2001-10-02
EP1015417A1 (en) 2000-07-05
AR013960A1 (es) 2001-01-31
IL134691A0 (en) 2001-04-30
EA003989B1 (ru) 2003-12-25
IN190983B (enExample) 2003-09-06
NZ502988A (en) 2002-08-28
AU747702B2 (en) 2002-05-16
ID25516A (id) 2000-10-05
WO1999014185A1 (en) 1999-03-25
EA200000332A1 (ru) 2000-10-30
KR20010024123A (ko) 2001-03-26
BR9812649A (pt) 2000-08-22
TR200000723T2 (tr) 2001-06-21

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