AU747702B2 - Compounds containing six-membered rings, processes for their preparation, and their use as medicaments - Google Patents

Compounds containing six-membered rings, processes for their preparation, and their use as medicaments Download PDF

Info

Publication number
AU747702B2
AU747702B2 AU95694/98A AU9569498A AU747702B2 AU 747702 B2 AU747702 B2 AU 747702B2 AU 95694/98 A AU95694/98 A AU 95694/98A AU 9569498 A AU9569498 A AU 9569498A AU 747702 B2 AU747702 B2 AU 747702B2
Authority
AU
Australia
Prior art keywords
group
groups
typically
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU95694/98A
Other languages
English (en)
Other versions
AU9569498A (en
Inventor
Norbert W Bischofberger
Terrence C. Dahl
Michael J.M. Hitchcock
Choung U. Kim
Willard Lew
Hongtao Liu
Roger G. Mills
Matthew A. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU9569498A publication Critical patent/AU9569498A/en
Application granted granted Critical
Publication of AU747702B2 publication Critical patent/AU747702B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU95694/98A 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments Expired AU747702B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US60/059308 1997-09-17
US6019597P 1997-09-26 1997-09-26
US93864497A 1997-09-26 1997-09-26
US60/060195 1997-09-26
US08/938644 1997-09-26
PCT/US1998/019355 WO1999014185A1 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Publications (2)

Publication Number Publication Date
AU9569498A AU9569498A (en) 1999-04-05
AU747702B2 true AU747702B2 (en) 2002-05-16

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
AU95694/98A Expired AU747702B2 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Country Status (15)

Country Link
EP (1) EP1015417A1 (enExample)
JP (1) JP2001516739A (enExample)
KR (1) KR20010024123A (enExample)
CN (1) CN1272105A (enExample)
AR (1) AR013960A1 (enExample)
AU (1) AU747702B2 (enExample)
BR (1) BR9812649A (enExample)
CA (1) CA2303323A1 (enExample)
EA (1) EA003989B1 (enExample)
ID (1) ID25516A (enExample)
IL (1) IL134691A0 (enExample)
IN (1) IN190983B (enExample)
NZ (1) NZ502988A (enExample)
TR (1) TR200000723T2 (enExample)
WO (1) WO1999014185A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1040094E (pt) * 1997-12-17 2009-06-03 Biocryst Pharm Inc Compostos de ciclopentano e de ciclopenteno substituídos úteis como inibidores da neuraminidase
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
EP1059283B1 (en) 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Process for preparing neuraminidase inhibitor ro-64-0796
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2001028981A1 (en) * 1999-10-19 2001-04-26 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
EP2178819A2 (en) 2005-12-28 2010-04-28 F.Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
CN102597120B (zh) * 2009-11-11 2015-05-27 3M创新有限公司 聚合物组合物及其制备方法和制品
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
WO2022022448A1 (zh) * 2020-07-29 2022-02-03 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN117105801B (zh) * 2023-07-24 2026-03-27 四川青木制药有限公司 一种奥司他韦及其磷酸盐的制备方法及其中间体
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途
CN118146111A (zh) * 2024-03-07 2024-06-07 上海泰坦企业发展有限公司 一种奥司他韦酸甲酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282950B6 (sk) * 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
CN100409844C (zh) * 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
EP0920410B1 (en) * 1996-08-23 2002-03-27 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives

Also Published As

Publication number Publication date
TR200000723T2 (tr) 2001-06-21
WO1999014185A1 (en) 1999-03-25
EA003989B1 (ru) 2003-12-25
EA200000332A1 (ru) 2000-10-30
AU9569498A (en) 1999-04-05
IN190983B (enExample) 2003-09-06
NZ502988A (en) 2002-08-28
KR20010024123A (ko) 2001-03-26
CN1272105A (zh) 2000-11-01
CA2303323A1 (en) 1999-03-25
JP2001516739A (ja) 2001-10-02
AR013960A1 (es) 2001-01-31
IL134691A0 (en) 2001-04-30
ID25516A (id) 2000-10-05
EP1015417A1 (en) 2000-07-05
BR9812649A (pt) 2000-08-22

Similar Documents

Publication Publication Date Title
AU720933B2 (en) Novel selective inhibitors of viral or bacterial neuraminidases
US5763483A (en) Carbocyclic compounds
AU9569498A (en) Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
WO1996026933A9 (en) Novel selective inhibitors of viral or bacterial neuraminidases
CA2188835C (en) Novel compounds and methods for synthesis and therapy
AU743333B2 (en) Piperidine compounds
US20040053999A1 (en) Novel compounds and methods for synthesis and therapy
AU2003204079B2 (en) Novel compounds and methods for synthesis and therapy
HK1120494B (en) Novel compounds and methods for synthesis and therapy
HK1115749A (en) Novel compounds and methods for synthesis and therapy
MXPA99003626A (en) Piperidine compounds
NZ517887A (en) Piperidine compounds useful for maintaining the structural integrity of glycoproteins in recombinant cell cultures (added to fermentation producing glycoproteins)

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired