CN1264819C - 前列环素衍生物的立体选择合成方法 - Google Patents

前列环素衍生物的立体选择合成方法 Download PDF

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Publication number
CN1264819C
CN1264819C CNB988126397A CN98812639A CN1264819C CN 1264819 C CN1264819 C CN 1264819C CN B988126397 A CNB988126397 A CN B988126397A CN 98812639 A CN98812639 A CN 98812639A CN 1264819 C CN1264819 C CN 1264819C
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CN
China
Prior art keywords
fluorine
alkyl
group
condition
methyl
Prior art date
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Expired - Lifetime
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CNB988126397A
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English (en)
Chinese (zh)
Other versions
CN1283184A (zh
Inventor
R·M·莫里尔蒂
R·彭马斯塔
L·郭
M·S·劳
J·P·斯塔舍夫斯基
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United Therapeutics Corp
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United Therapeutics Corp
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Publication of CN1283184A publication Critical patent/CN1283184A/zh
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Publication of CN1264819C publication Critical patent/CN1264819C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
CNB988126397A 1997-10-24 1998-10-26 前列环素衍生物的立体选择合成方法 Expired - Lifetime CN1264819C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95773697A 1997-10-24 1997-10-24
US08/957,736 1997-10-24

Publications (2)

Publication Number Publication Date
CN1283184A CN1283184A (zh) 2001-02-07
CN1264819C true CN1264819C (zh) 2006-07-19

Family

ID=25500067

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988126397A Expired - Lifetime CN1264819C (zh) 1997-10-24 1998-10-26 前列环素衍生物的立体选择合成方法

Country Status (11)

Country Link
EP (1) EP1025083B1 (enExample)
JP (1) JP3717053B2 (enExample)
KR (1) KR100447022B1 (enExample)
CN (1) CN1264819C (enExample)
AT (1) ATE245628T1 (enExample)
CA (2) CA2847985C (enExample)
DE (1) DE69816642T2 (enExample)
DK (1) DK1025083T3 (enExample)
ES (1) ES2198760T3 (enExample)
PT (1) PT1025083E (enExample)
WO (1) WO1999021830A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
ES2622471T5 (es) 2003-05-22 2020-07-23 United Therapeutics Corp Compuestos y procedimientos para la administración de análogos de prostaciclina
CA2698721A1 (en) 2007-09-07 2009-03-12 United Therapeutics Corporation Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
CA2710205C (en) * 2007-12-17 2016-04-26 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
CN101891596B (zh) * 2009-05-22 2013-12-11 上海天伟生物制药有限公司 一种化合物及其制备方法和用途
CN103261142B (zh) * 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
US20130345471A1 (en) * 2011-03-02 2013-12-26 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
US8524939B2 (en) * 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) * 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CA3125504C (en) 2013-03-14 2023-10-24 United Therapeutics Corporation Solid forms of treprostinil
HU231184B1 (hu) * 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
WO2016064764A1 (en) 2014-10-20 2016-04-28 United Therapeutics Corporation Synthesis of intermediate for producing prostacyclin derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
DE19708496A1 (de) * 1997-03-03 1998-09-10 Hoechst Ag Verfahren zur enantionmerenreinen Anthracylin-Synthese

Also Published As

Publication number Publication date
JP3717053B2 (ja) 2005-11-16
DE69816642T2 (de) 2004-06-09
CA2307163A1 (en) 1999-05-06
EP1025083A1 (en) 2000-08-09
KR20010031309A (ko) 2001-04-16
ATE245628T1 (de) 2003-08-15
WO1999021830A8 (en) 1999-07-22
KR100447022B1 (ko) 2004-09-07
EP1025083B1 (en) 2003-07-23
ES2198760T3 (es) 2004-02-01
PT1025083E (pt) 2003-10-31
CA2307163C (en) 2014-05-06
DE69816642D1 (de) 2003-08-28
CA2847985A1 (en) 1999-05-06
DK1025083T3 (da) 2004-03-01
CA2847985C (en) 2015-02-03
CN1283184A (zh) 2001-02-07
WO1999021830A1 (en) 1999-05-06
JP2004500303A (ja) 2004-01-08

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Granted publication date: 20060719