CN1252057C - 用于治疗与paar有关的疾病的噻唑衍生物 - Google Patents

用于治疗与paar有关的疾病的噻唑衍生物 Download PDF

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Publication number
CN1252057C
CN1252057C CNB018223095A CN01822309A CN1252057C CN 1252057 C CN1252057 C CN 1252057C CN B018223095 A CNB018223095 A CN B018223095A CN 01822309 A CN01822309 A CN 01822309A CN 1252057 C CN1252057 C CN 1252057C
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CN
China
Prior art keywords
methyl
trifluoromethyl
thiazole
title compound
phenoxy group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018223095A
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English (en)
Chinese (zh)
Other versions
CN1527822A (zh
Inventor
R·卡迪拉
R·L·M·戈斯米尼
M·H·拉姆伯特三世
M·L·西拉
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of CN1527822A publication Critical patent/CN1527822A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018223095A 2000-12-20 2001-12-19 用于治疗与paar有关的疾病的噻唑衍生物 Expired - Fee Related CN1252057C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0031107.6 2000-12-20
GBGB0031107.6A GB0031107D0 (en) 2000-12-20 2000-12-20 Chemical compounds

Publications (2)

Publication Number Publication Date
CN1527822A CN1527822A (zh) 2004-09-08
CN1252057C true CN1252057C (zh) 2006-04-19

Family

ID=9905492

Family Applications (1)

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CNB018223095A Expired - Fee Related CN1252057C (zh) 2000-12-20 2001-12-19 用于治疗与paar有关的疾病的噻唑衍生物

Country Status (27)

Country Link
EP (1) EP1343773B1 (enExample)
JP (1) JP4209681B2 (enExample)
KR (1) KR100815022B1 (enExample)
CN (1) CN1252057C (enExample)
AR (1) AR035522A1 (enExample)
AT (1) ATE344253T1 (enExample)
AU (1) AU2002246713B2 (enExample)
BR (1) BR0116370A (enExample)
CA (1) CA2432188A1 (enExample)
CY (1) CY1105915T1 (enExample)
CZ (1) CZ20031737A3 (enExample)
DE (1) DE60124302T2 (enExample)
DK (1) DK1343773T3 (enExample)
ES (1) ES2274914T3 (enExample)
GB (1) GB0031107D0 (enExample)
HU (1) HUP0400837A3 (enExample)
IL (2) IL156436A0 (enExample)
MX (1) MXPA03005699A (enExample)
MY (1) MY136685A (enExample)
NO (1) NO20032801L (enExample)
NZ (1) NZ526543A (enExample)
PL (1) PL365797A1 (enExample)
PT (1) PT1343773E (enExample)
SI (1) SI1343773T1 (enExample)
TW (1) TWI292759B (enExample)
WO (1) WO2002062774A1 (enExample)
ZA (1) ZA200304679B (enExample)

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GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US20040072838A1 (en) 2000-12-20 2004-04-15 Pierette Banker Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
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WO2003072100A1 (en) * 2002-02-25 2003-09-04 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
ATE415160T1 (de) 2002-02-25 2008-12-15 Lilly Co Eli Modulatoren von peroxisome proliferator- aktivierten rezeptoren
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US20030207924A1 (en) * 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
US7244763B2 (en) 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
US6987118B2 (en) 2003-05-21 2006-01-17 Pfizer Inc. Tetrahydroisoquinoline derivatives as PPAR-alpha activators
RU2005141516A (ru) * 2003-06-06 2007-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Производные анилина
WO2005005423A1 (en) 2003-07-02 2005-01-20 F. Hoffmann-La Roche Ag Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators
PL1667964T3 (pl) 2003-09-19 2010-01-29 Janssen Pharmaceutica Nv Kwasy 4-((fenoksyalkilo)tio)-fenoksyoctowe i analogi
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
KR20070004769A (ko) 2004-02-27 2007-01-09 암젠 인코포레이션 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법
JP4981662B2 (ja) 2004-05-05 2012-07-25 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 新規の化合物、その製法と使用
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MY145712A (en) 2004-09-15 2012-03-30 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
MY147518A (en) * 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
EP1841748B1 (en) * 2004-12-31 2011-12-28 Seoul National University Industry Foundation Organoselenium containing compounds and their use
JP5191744B2 (ja) * 2005-02-25 2013-05-08 ソウル ナショナル ユニバーシティー インダストリー ファンデーション ペルオキシソーム増殖子活性化受容体デルタリガンドのチアゾール誘導体及びその製造方法
EP1856072A4 (en) * 2005-02-25 2009-10-21 Seoul Nat Univ Ind Foundation THIAZOLE DERIVATIVES AS PPAR DELTA LIGANDS AND PROCESSES FOR THE PRODUCTION THEREOF
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
RU2412935C2 (ru) 2005-06-30 2011-02-27 Хай Пойнт Фармасьютикалс, ЛЛС Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
EP1924546A1 (en) 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EA201101084A1 (ru) 2005-12-22 2012-04-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Феноксиуксусные кислоты в качестве активаторов ppar дельта
CN101007790B (zh) * 2006-01-27 2011-03-30 北京摩力克科技有限公司 草氨酸衍生物、其制备方法和医药用途
US7943612B2 (en) 2006-03-09 2011-05-17 High Point Pharmaceuticals, Llc Compounds that modulate PPAR activity, their preparation and use
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Also Published As

Publication number Publication date
CY1105915T1 (el) 2011-04-06
ES2274914T3 (es) 2007-06-01
TWI292759B (en) 2008-01-21
DE60124302T2 (de) 2007-05-03
NO20032801L (no) 2003-08-04
NZ526543A (en) 2004-11-26
CZ20031737A3 (cs) 2003-10-15
MY136685A (en) 2008-11-28
KR20030072571A (ko) 2003-09-15
IL156436A (en) 2008-06-05
MXPA03005699A (es) 2003-10-06
IL156436A0 (en) 2004-01-04
HUP0400837A3 (en) 2007-11-28
GB0031107D0 (en) 2001-01-31
DE60124302D1 (de) 2006-12-14
EP1343773A1 (en) 2003-09-17
JP2004518702A (ja) 2004-06-24
AR035522A1 (es) 2004-06-02
ATE344253T1 (de) 2006-11-15
CN1527822A (zh) 2004-09-08
WO2002062774A1 (en) 2002-08-15
KR100815022B1 (ko) 2008-03-18
DK1343773T3 (da) 2007-02-05
CA2432188A1 (en) 2002-08-15
EP1343773B1 (en) 2006-11-02
HK1059925A1 (en) 2004-07-23
AU2002246713B2 (en) 2004-09-09
PT1343773E (pt) 2007-02-28
ZA200304679B (en) 2004-10-04
BR0116370A (pt) 2003-12-09
JP4209681B2 (ja) 2009-01-14
SI1343773T1 (sl) 2007-04-30
PL365797A1 (en) 2005-01-10
NO20032801D0 (no) 2003-06-19
HUP0400837A2 (hu) 2004-08-30

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